Pub Date : 2025-01-20DOI: 10.1016/j.clinph.2024.12.027
Alex Martino Cinnera , Elias Paolo Casula , Valentina Pezzopane , Alessia D’Acunto , Michele Maiella , Sonia Bonnì , Matteo Ferraresi , Marcella Guacci , Marco Tramontano , Marco Iosa , Stefano Paolucci , Giovanni Morone , Giuseppe Vannozzi , Giacomo Koch
Objective
We aimed to investigate the involvement of interhemispheric cortical dynamics as measured by combined transcranial magnetic stimulation and electroencephalography (TMS-EEG) in recovery of upper limb (UL) motor functions in chronic stroke patients.
Methods
Ten patients with a history of single ischemic chronic stroke were enrolled (4F, 63.8 ± 9.9 years). Each patient underwent TMS-EEG recordings to evaluate interhemispheric cortical dynamics as well as a reaching task recorded with inertial measurement units, and a series of clinical assessments. TMS-EEG neurophysiological data were analysed considering spatiotemporal, power response, and interhemispheric balance (IHB) dynamics.
Results
We found that IHB index (IHBi) and low-frequency power (LFP) (4–13 Hz) in the affected hemisphere were associated with the degree of UL impairment.
Conclusion
Increased IHBi due to stroke is an unfavourable factor of UL’ functions. Similarly, LFP of both hemispheres is strongly correlated with clinical and kinematic outcomes.
Significance
TMS-EEG biomarkers of interhemispheric unbalance could be used to estimate functional recovery and drive tailored neuromodulation and neurorehabilitation approaches.
{"title":"Association of TMS-EEG interhemispheric imbalance with upper limb motor impairment in chronic stroke patients: An exploratory study","authors":"Alex Martino Cinnera , Elias Paolo Casula , Valentina Pezzopane , Alessia D’Acunto , Michele Maiella , Sonia Bonnì , Matteo Ferraresi , Marcella Guacci , Marco Tramontano , Marco Iosa , Stefano Paolucci , Giovanni Morone , Giuseppe Vannozzi , Giacomo Koch","doi":"10.1016/j.clinph.2024.12.027","DOIUrl":"10.1016/j.clinph.2024.12.027","url":null,"abstract":"<div><h3>Objective</h3><div>We aimed to investigate the involvement of interhemispheric cortical dynamics as measured by combined transcranial magnetic stimulation and electroencephalography (TMS-EEG) in recovery of upper limb (UL) motor functions in chronic stroke patients.</div></div><div><h3>Methods</h3><div>Ten patients with a history of single ischemic chronic stroke were enrolled (4F, 63.8 ± 9.9 years). Each patient underwent TMS-EEG recordings to evaluate interhemispheric cortical dynamics as well as a reaching task recorded with inertial measurement units, and a series of clinical assessments. TMS-EEG neurophysiological data were analysed considering spatiotemporal, power response, and interhemispheric balance (IHB) dynamics.</div></div><div><h3>Results</h3><div>We found that IHB index (IHB<em>i)</em> and low-frequency power (LFP) (4–13 Hz) in the affected hemisphere were associated with the degree of UL impairment.</div></div><div><h3>Conclusion</h3><div>Increased IHB<em>i</em> due to stroke is an unfavourable factor of UL’ functions. Similarly, LFP of both hemispheres is strongly correlated with clinical and kinematic outcomes.</div></div><div><h3>Significance</h3><div>TMS-EEG biomarkers of interhemispheric unbalance could be used to estimate functional recovery and drive tailored neuromodulation and neurorehabilitation approaches.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"171 ","pages":"Pages 95-106"},"PeriodicalIF":3.7,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-20DOI: 10.1016/j.clinph.2024.12.022
Christian Ariel Mista , Elizabeth Loreley Young , Silvio Jorge Laugero , José Alberto Biurrun Manresa
Objective
To describe the cortical evoked potentials in response to radiofrequency stimulation (RFEPs) in human volunteers.
Methods
Seventeen healthy volunteers participated in an experimental session in which radiofrequency (RF) and electrical (ES) stimulation were applied to the dorsum of the hands and feet. EEG was recorded to evaluate evoked responses for each stimulus modality and stimulation site.
Results
Electrophysiological results showed highly synchronous responses compatible with activation of heat-sensitive nociceptors. Latencies of the N2 and P2 peaks in the RFEPs were longer compared to EPs evoked by ES. Furthermore, the latency of the P2 peak was also longer after stimulation of the feet compared to the hand.
Conclusions
RF stimulation is capable of selective activation of nociceptive fibres by means of rapid skin heating. RFEPs showed the highest degree of synchronicity achieved to date for evoked cortical responses to thermal stimulation.
Significance
RF stimulation represents a viable alternative in the experimental and clinical assessment of the nociceptive system.
{"title":"Radiofrequency evoked potentials: A new window into the nociceptive system","authors":"Christian Ariel Mista , Elizabeth Loreley Young , Silvio Jorge Laugero , José Alberto Biurrun Manresa","doi":"10.1016/j.clinph.2024.12.022","DOIUrl":"10.1016/j.clinph.2024.12.022","url":null,"abstract":"<div><h3>Objective</h3><div>To describe the cortical evoked potentials in response to radiofrequency stimulation (RFEPs) in human volunteers.</div></div><div><h3>Methods</h3><div>Seventeen healthy volunteers participated in an experimental session in which radiofrequency (RF) and electrical (ES) stimulation were applied to the dorsum of the hands and feet. EEG was recorded to evaluate evoked responses for each stimulus modality and stimulation site.</div></div><div><h3>Results</h3><div>Electrophysiological results showed highly synchronous responses compatible with activation of heat-sensitive nociceptors. Latencies of the N2 and P2 peaks in the RFEPs were longer compared to EPs evoked by ES. Furthermore, the latency of the P2 peak was also longer after stimulation of the feet compared to the hand.</div></div><div><h3>Conclusions</h3><div>RF stimulation is capable of selective activation of nociceptive fibres by means of rapid skin heating. RFEPs showed the highest degree of synchronicity achieved to date for evoked cortical responses to thermal stimulation.</div></div><div><h3>Significance</h3><div>RF stimulation represents a viable alternative in the experimental and clinical assessment of the nociceptive system.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"171 ","pages":"Pages 21-30"},"PeriodicalIF":3.7,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143037480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-20DOI: 10.1016/j.clinph.2025.01.003
G.V. Anguelova , J. VanderEnde , C.I.A. van Houdt , C.G.J. Saris
{"title":"Ulnar artery arteriovenous malformation with an intraneural ulnar nerve component; case report and literature review","authors":"G.V. Anguelova , J. VanderEnde , C.I.A. van Houdt , C.G.J. Saris","doi":"10.1016/j.clinph.2025.01.003","DOIUrl":"10.1016/j.clinph.2025.01.003","url":null,"abstract":"","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"171 ","pages":"Pages 18-20"},"PeriodicalIF":3.7,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143036759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-20DOI: 10.1016/j.clinph.2025.01.001
Natalia Madetko-Alster , Piotr Alster , Martin Lamoš , Lucia Šmahovská , Tomáš Boušek , Ivan Rektor , Martina Bočková
Objective
The aim of this work was to study the differences at the whole-brain level between self-paced and cued movement processing in Parkinson’s disease (PD).
Methods
High density electroencephalogram (HD-EEG) was recorded during the performance of self-paced movements (Bereitschaftspotential − BP) and visually cued movements (VMT) in PD patients (n = 38) and in a group of healthy controls (HC, n = 23). Oscillatory changes in the alpha, beta, and gamma frequencies were evaluated and correlated to the clinical scales- MDS-UPDRS and Freezing of Gait Questionnaire (FOGQ).
Results
The main difference in the alpha range was an activation in the basal ganglia area during VMT performance as compared to BP performance; this activation was present only in HC. The most important finding was observed in the high beta range: a higher activation of the right postcentral area during BP performance in PD subjects as compared to HC, correlating to the severity of FOG. Moreover, PD patients had lower gamma activation of the right frontal areas.
Conclusion
A simplification of motor circuits and a hyperactivation of the right somatosensory cortex were observed in PD subjects.
Significance
Future studies should be focused on this area to confirm or disprove its role in FOG.
{"title":"The role of the somatosensory cortex in self-paced movement impairment in Parkinson’s disease","authors":"Natalia Madetko-Alster , Piotr Alster , Martin Lamoš , Lucia Šmahovská , Tomáš Boušek , Ivan Rektor , Martina Bočková","doi":"10.1016/j.clinph.2025.01.001","DOIUrl":"10.1016/j.clinph.2025.01.001","url":null,"abstract":"<div><h3>Objective</h3><div>The aim of this work was to study the differences at the whole-brain level between self-paced and cued movement processing in Parkinson’s disease (PD).</div></div><div><h3>Methods</h3><div>High density electroencephalogram (HD-EEG) was recorded during the performance of self-paced movements (Bereitschaftspotential − BP) and visually cued movements (VMT) in PD patients (n = 38) and in a group of healthy controls (HC, n = 23). Oscillatory changes in the alpha, beta, and gamma frequencies were evaluated and correlated to the clinical scales- MDS-UPDRS and Freezing of Gait Questionnaire (FOGQ).</div></div><div><h3>Results</h3><div>The main difference in the alpha range was an activation in the basal ganglia area during VMT performance as compared to BP performance; this activation was present only in HC. The most important finding was observed in the high beta range: a higher activation of the right postcentral area during BP performance in PD subjects as compared to HC, correlating to the severity of FOG. Moreover, PD patients had lower gamma activation of the right frontal areas.</div></div><div><h3>Conclusion</h3><div>A simplification of motor circuits and a hyperactivation of the right somatosensory cortex were observed in PD subjects.</div></div><div><h3>Significance</h3><div>Future studies should be focused on this area to confirm or disprove its role in FOG.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"171 ","pages":"Pages 11-17"},"PeriodicalIF":3.7,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143037481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-20DOI: 10.1016/j.clinph.2024.12.020
Changqiong Zhou , Chenxi Qiu , Chunge Pan , Yan Li , Yingying Tang , Ziyi Chen , Ying Liu , Sijia Guo , Jing Lu , Bo Yan , Xiaoting Hao
Objective
Sleep-related hypermotor epilepsy (SHE) is a relatively uncommon epilepsy syndrome, characterized by seizures closely related to the sleep cycle. This study aims to explore interictal electroencephalographic (EEG) characteristics in SHE.
Methods
We compared EEG data from 20 patients with SHE, 20 patients with focal epilepsy (FE), and 14 healthy controls, carefully matched for age, sex, education level, epilepsy duration, and drug-resistant epilepsy.
Results
Our findings revealed distinct patterns of power spectral density in SHE patients during wakefulness and N2 sleep compared to other groups, suggesting potential diagnostic value. During wakefulness, SHE patients showed enhanced frontal lobe power across all frequency bands, but decreased frontal lobe power in low-frequency bands during N2 sleep. Additionally, a positive correlation was found between frontal γ band power and epilepsy duration in SHE patients during N2 sleep but not during wakefulness.
Conclusions
These findings suggest that interictal EEG abnormalities during wakefulness and N2 sleep might be used as potential biomarkers for the diagnosis of SHE.
Significance
This study is the first to simultaneously characterize EEG during sleep and wakefulness in SHE patients during interictal periods, with potential utility for diagnosis.
{"title":"Brain changes in sleep-related hypermotor epilepsy observed from wakefulness and N2 sleep: A matched case-control study","authors":"Changqiong Zhou , Chenxi Qiu , Chunge Pan , Yan Li , Yingying Tang , Ziyi Chen , Ying Liu , Sijia Guo , Jing Lu , Bo Yan , Xiaoting Hao","doi":"10.1016/j.clinph.2024.12.020","DOIUrl":"10.1016/j.clinph.2024.12.020","url":null,"abstract":"<div><h3>Objective</h3><div>Sleep-related hypermotor epilepsy (SHE) is a relatively uncommon epilepsy syndrome, characterized by seizures closely related to the sleep cycle. This study aims to explore interictal electroencephalographic (EEG) characteristics in SHE.</div></div><div><h3>Methods</h3><div>We compared EEG data from 20 patients with SHE, 20 patients with focal epilepsy (FE), and 14 healthy controls, carefully matched for age, sex, education level, epilepsy duration, and drug-resistant epilepsy.</div></div><div><h3>Results</h3><div>Our findings revealed distinct patterns of power spectral density in SHE patients during wakefulness and N2 sleep compared to other groups, suggesting potential diagnostic value. During wakefulness, SHE patients showed enhanced frontal lobe power across all frequency bands, but decreased frontal lobe power in low-frequency bands during N2 sleep. Additionally, a positive correlation was found between frontal γ band power and epilepsy duration in SHE patients during N2 sleep but not during wakefulness.</div></div><div><h3>Conclusions</h3><div>These findings suggest that interictal EEG abnormalities during wakefulness and N2 sleep might be used as potential biomarkers for the diagnosis of SHE.</div></div><div><h3>Significance</h3><div>This study is the first to simultaneously characterize EEG during sleep and wakefulness in SHE patients during interictal periods, with potential utility for diagnosis.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"171 ","pages":"Pages 31-37"},"PeriodicalIF":3.7,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143037477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-17DOI: 10.1016/j.clinph.2024.12.019
Christian Krarup, Nils Wolfram, Siska Frahm-Falkenberg, Carolina C Graffe, Tina Dysgaard, Ali Al-Zuhairy, Johannes K Jakobsen, Mihai Moldovan
Objective: To investigate motor axonal excitability in multifocal motor neuropathy (MMN) associated with involuntary muscle activity.
Methods: Two MMN patients with continuous involuntary finger movements (MMNifm) were compared to 11 patients without movements (MMNnfm). Clinical examination, EMG of the abductor pollicis brevis muscle, nerve conduction studies, motor unit number estimation, excitability studies, and mathematical modeling were conducted in the patients with MMN and compared to controls.
Results: Weakness, axonal loss, conduction block, or both occurred in the median nerve in the MMNifm and the MMNnfm patients. Ultrasound studies (US) in MMNifm showed enlargement of the nerves at the axilla/brachial plexus at the site of the conduction block. In MMNifm, EMG and the US showed continuous involuntary contractions, and excitability studies of the median nerve at the wrist showed increased threshold reduction during early depolarizing electrotonus and at early recovery cycle (superexcitability). Mathematical modeling was consistent with reduced fast K+ current more pronounced in MMNifm than in MMNnfm.
Conclusions: MMN may have a spectrum of changes associated with instability of the axonal membrane which may be due to paranodal myelin loosening.
Significance: In addition to motor conduction block and axonal loss, MMN has pathophysiological changes that suggest more widespread involvement of motor myelinated fibers.
{"title":"Spontaneous muscle activity in multifocal motor neuropathy - Insights from axonal excitability testing.","authors":"Christian Krarup, Nils Wolfram, Siska Frahm-Falkenberg, Carolina C Graffe, Tina Dysgaard, Ali Al-Zuhairy, Johannes K Jakobsen, Mihai Moldovan","doi":"10.1016/j.clinph.2024.12.019","DOIUrl":"https://doi.org/10.1016/j.clinph.2024.12.019","url":null,"abstract":"<p><strong>Objective: </strong>To investigate motor axonal excitability in multifocal motor neuropathy (MMN) associated with involuntary muscle activity.</p><p><strong>Methods: </strong>Two MMN patients with continuous involuntary finger movements (MMNifm) were compared to 11 patients without movements (MMNnfm). Clinical examination, EMG of the abductor pollicis brevis muscle, nerve conduction studies, motor unit number estimation, excitability studies, and mathematical modeling were conducted in the patients with MMN and compared to controls.</p><p><strong>Results: </strong>Weakness, axonal loss, conduction block, or both occurred in the median nerve in the MMNifm and the MMNnfm patients. Ultrasound studies (US) in MMNifm showed enlargement of the nerves at the axilla/brachial plexus at the site of the conduction block. In MMNifm, EMG and the US showed continuous involuntary contractions, and excitability studies of the median nerve at the wrist showed increased threshold reduction during early depolarizing electrotonus and at early recovery cycle (superexcitability). Mathematical modeling was consistent with reduced fast K<sup>+</sup> current more pronounced in MMNifm than in MMNnfm.</p><p><strong>Conclusions: </strong>MMN may have a spectrum of changes associated with instability of the axonal membrane which may be due to paranodal myelin loosening.</p><p><strong>Significance: </strong>In addition to motor conduction block and axonal loss, MMN has pathophysiological changes that suggest more widespread involvement of motor myelinated fibers.</p>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143036878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01DOI: 10.1016/j.clinph.2024.10.016
Clotilde Turpin , Olivier Rossel , Félix Schlosser-Perrin , Sam Ng , Riki Matsumoto , Emmanuel Mandonnet , Hugues Duffau , François Bonnetblanc
Objective
Direct cortical responses (DCR) and axono-cortical evoked potentials (ACEP) are generated by electrically stimulating the cortex either directly or indirectly through white matter pathways, potentially leading to different electrogenic processes. For ACEP, the slow conduction velocity of axons (median ≈ 4 m.s−1) is anticipated to induce a delay. For DCR, direct electrical stimulation (DES) of the cortex is expected to elicit additional cortical activity involving smaller and slower non-myelinated axons. We tried to validate these hypotheses.
Methods
DES was administered either directly on the cortex or to white matter fascicles within the resection cavity, while recording DCR or ACEP at the cortical level in nine patients.
Results
Short but significant delays (≈ 2 ms) were measurable for ACEP immediately following the initial component (≈ 7 ms). Subsequent activities (≈ 40 ms) exhibited notable differences between DCR and ACEP, suggesting the presence of additional cortical activities for DCR.
Conclusion
Distinctions between ACEPs and DCRs can be made based on a delay at the onset of early components and the dissimilarity in the shape of the later components (>40 ms after the DES artifact).
Significance
The comparison of different types of evoked potentials allows to better understand the effects of DES.
{"title":"Shapes of direct cortical responses vs. short-range axono-cortical evoked potentials: The effects of direct electrical stimulation applied to the human brain","authors":"Clotilde Turpin , Olivier Rossel , Félix Schlosser-Perrin , Sam Ng , Riki Matsumoto , Emmanuel Mandonnet , Hugues Duffau , François Bonnetblanc","doi":"10.1016/j.clinph.2024.10.016","DOIUrl":"10.1016/j.clinph.2024.10.016","url":null,"abstract":"<div><h3>Objective</h3><div>Direct cortical responses (DCR) and axono-cortical evoked potentials (ACEP) are generated by electrically stimulating the cortex either directly or indirectly through white matter pathways, potentially leading to different electrogenic processes. For ACEP, the slow conduction velocity of axons (median ≈ 4 m.s<sup>−1</sup>) is anticipated to induce a delay. For DCR, direct electrical stimulation (DES) of the cortex is expected to elicit additional cortical activity involving smaller and slower non-myelinated axons. We tried to validate these hypotheses.</div></div><div><h3>Methods</h3><div>DES was administered either directly on the cortex or to white matter fascicles within the resection cavity, while recording DCR or ACEP at the cortical level in nine patients.</div></div><div><h3>Results</h3><div>Short but significant delays (≈ 2 ms) were measurable for ACEP immediately following the initial component (≈ 7 ms). Subsequent activities (≈ 40 ms) exhibited notable differences between DCR and ACEP, suggesting the presence of additional cortical activities for DCR.</div></div><div><h3>Conclusion</h3><div>Distinctions between ACEPs and DCRs can be made based on a delay at the onset of early components and the dissimilarity in the shape of the later components (>40 ms after the DES artifact).</div></div><div><h3>Significance</h3><div>The comparison of different types of evoked potentials allows to better understand the effects of DES.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"169 ","pages":"Pages 91-99"},"PeriodicalIF":3.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142692353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01DOI: 10.1016/j.clinph.2024.11.016
Fabio Ferrarelli
{"title":"Unraveling prefrontal cortical inhibitory dynamics: A novel approach to investigate GABAergic function with TMS-EEG","authors":"Fabio Ferrarelli","doi":"10.1016/j.clinph.2024.11.016","DOIUrl":"10.1016/j.clinph.2024.11.016","url":null,"abstract":"","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"169 ","pages":"Pages 100-101"},"PeriodicalIF":3.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142779175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01DOI: 10.1016/j.clinph.2024.10.017
Edward C. Brown , Andrew Bowers , M.Blake Rafferty , Devin M. Casenhiser , Kevin Reilly , Ashley Harkrider , Tim Saltuklaroglu
Objective
Motivated by previous inconsistent findings, this study aims to improve understanding of sensorimotor beta (β; 15–30 Hz) and alpha (α; 8–14 Hz) speech-related power differences between stuttering and non-stuttering adults.
Methods
Electroencephalography was recorded as adults who stutter (AWS) and matched fluent controls answered questions in Quiet and Informational Masked backgrounds. Bilateral sensorimotor β and α power during speech planning and execution were measured from mu (μ) rhythm components.
Results
Compared to controls, AWS exhibited reduced left hemisphere β and α power in both speaking conditions during speech planning and execution. AWS displayed reduced left α power in the Informational Masking compared to Quiet. Within AWS β and α power, which were tightly coupled, oppositely predicted stuttering severity and β-α dissociation (β minus α) was the strongest predictor.
Conclusion
Neither β nor α power are reliable markers of speech motor stability due to their sensitivity to speech task automaticity. However, relationships between these two sensorimotor rhythms warrant further investigation for understanding motor control.
Significance
Data help explain previous mixed findings in reference to extant models of speech motor control in stuttering and may have clinical implications for developing neurostimulation protocols targeting improved speech fluency.
{"title":"Influences of speaking task demands on sensorimotor oscillations in adults who stutter: Implications for speech motor control","authors":"Edward C. Brown , Andrew Bowers , M.Blake Rafferty , Devin M. Casenhiser , Kevin Reilly , Ashley Harkrider , Tim Saltuklaroglu","doi":"10.1016/j.clinph.2024.10.017","DOIUrl":"10.1016/j.clinph.2024.10.017","url":null,"abstract":"<div><h3>Objective</h3><div>Motivated by previous inconsistent findings, this study aims to improve understanding of sensorimotor beta (β; 15–30 Hz) and alpha (α; 8–14 Hz) speech-related power differences between stuttering and non-stuttering adults.</div></div><div><h3>Methods</h3><div>Electroencephalography was recorded as adults who stutter (AWS) and matched fluent controls answered questions in Quiet and Informational Masked backgrounds. Bilateral sensorimotor β and α power during speech planning and execution were measured from mu (μ) rhythm components.</div></div><div><h3>Results</h3><div>Compared to controls, AWS exhibited reduced left hemisphere β and α power in both speaking conditions during speech planning and execution. AWS displayed reduced left α power in the Informational Masking compared to Quiet. Within AWS β and α power, which were tightly coupled, oppositely predicted stuttering severity and β-α dissociation (β minus α) was the strongest predictor.</div></div><div><h3>Conclusion</h3><div>Neither β nor α power are reliable markers of speech motor stability due to their sensitivity to speech task automaticity. However, relationships between these two sensorimotor rhythms warrant further investigation for understanding motor control.</div></div><div><h3>Significance</h3><div>Data help explain previous mixed findings in reference to extant models of speech motor control in stuttering and may have clinical implications for developing neurostimulation protocols targeting improved speech fluency.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"169 ","pages":"Pages 76-88"},"PeriodicalIF":3.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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