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Resting-state Quantitative EEG Spectral Patterns in Migraine During Ictal Phase Reveal Deviant Brain Oscillations: Potential Role of Density Spectral Array. 偏头痛的静息态定量脑电图频谱模式揭示了偏离的大脑振荡:密度谱阵列的潜在作用。
IF 2 4区 医学 Q2 Medicine Pub Date : 2024-05-01 Epub Date: 2022-12-06 DOI: 10.1177/15500594221142951
Pooja Ojha, Samhita Panda

Background. Migraine headache may have a substantial bearing on the brain functions and rhythms. Electrophysiological methods can detect changes in brain oscillation. The present work examined the frequency band power through quantitative electroencephalogram (qEEG) and density spectral array (DSA) to elucidate the resting state neuronal oscillations in migraine. Methods. Clinical details were inquired, and EEG was recorded in migraineurs and healthy controls. The acquired data were analyzed to determine power spectral density values and obtain DSA graphs. The absolute and relative powers for the alpha, theta, and delta frequencies in frontocentral, parieto-occipital, and temporal regions were determined. A correlation of significant EEG findings with clinical features of migraine was sought. Results. Forty-five participants were enrolled in the study. The spectrum analysis revealed an increase in the relative theta power (P < .001) and a reduction in relative alpha power (P < .001) in the observed cortical areas among the migraineurs as compared to the healthy controls. Relative delta power was increased over the frontocentral region (P = .001), slightly more on the symptomatic side of the head. In addition, frontocentral delta power had a moderate positive correlation (r = .697, n = 22, P = .000) with migraine severity. Conclusion. The study supports the evidence of a neuronal dysfunction existing in the resting state during the ictal phase of migraine. qEEG can reveal these aberrant oscillations. Utility of DSA to depict the changes in brain activity in migraine is a potential area for research. The information can help formulate new therapeutic strategies towards alteration in cortical excitability using brain stimulation techniques.

背景。偏头痛可能对大脑功能和节律有很大影响。电生理方法可以检测大脑振荡的变化。本研究通过定量脑电图(qEEG)和密度谱阵列(DSA)检测频带功率,以阐明偏头痛患者的静息状态神经元振荡。研究方法询问偏头痛患者和健康对照组的临床详情,并记录他们的脑电图。对采集的数据进行分析,以确定功率谱密度值并获得 DSA 图形。确定了前中央区、顶枕区和颞区的α、θ和δ频率的绝对功率和相对功率。研究人员寻求了重要脑电图结果与偏头痛临床特征之间的相关性。研究结果45 名参与者参加了研究。频谱分析显示,相对θ功率增加(P P P = .001),有症状的一侧头部θ功率略有增加。此外,前中心德尔塔功率与偏头痛严重程度呈中度正相关(r = .697, n = 22, P = .000)。结论该研究支持偏头痛发作期静息状态下存在神经元功能障碍的证据。利用DSA描述偏头痛患者大脑活动的变化是一个潜在的研究领域。这些信息有助于制定新的治疗策略,利用脑刺激技术改变大脑皮层的兴奋性。
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引用次数: 0
Event-Related Potential Changes Following 12-week Yoga Practice in T2DM Patients: A Randomized Controlled Trial T2DM 患者练习瑜伽 12 周后的事件相关电位变化:随机对照试验
IF 2 4区 医学 Q2 Medicine Pub Date : 2024-05-01 DOI: 10.1177/15500594241249511
Amit Kanthi, Singh Deepeshwar, Kaligal Chidananda, Mahadevappa Vidyashree, Dwivedi Krishna
Introduction. Type 2 diabetes patients are more likely to experience cognitive decline (1.5%) and dementia (1.6%) than healthy individuals. Although cognitive impairment adversely affects Type 2 diabetes mellitus (T2DM) patients, it is the least addressed complication of T2DM patients. Objective. The present study attempts to examine the changes in cognitive performance of T2DM patients and the probable factors contributing to the changes following 12-week yoga practice. Methods. The current study is a parallel group randomized controlled trial that compared the outcomes of the participants randomized to a yoga group (YG) ( n = 25) and to a wait-list control group ( n = 29). The study assessed N200 and N450 event-related potential (ERP) components following the Stroop task, heart rate variability (HRV) and HbA1c before and after the intervention. Results. The mean amplitude of the N200 ERP component showed a significant group difference after the intervention, demonstrating an improved neural efficiency in the process of conflict monitoring and response inhibition. No differences were present for the N450 component. T2DM patients showed reduced heart rate and increased mean RR following yoga practice without any corresponding changes in other HRV parameters, demonstrating an overall improvement in cardiac activity. Along with that yoga practice also reduced HbA1c levels in T2DM patients, indicating improved glycemic control. Moreover, HbA1c levels were negatively correlated with reaction time after the intervention, indicating an impact of glycemic control on cognitive performance. Conclusion. The 12-week yoga practice improved cognitive performance by enhancing the processes of conflict monitoring and response inhibition. Further, improved cognitive performance postintervention was facilitated by improved glycemic control.
简介与健康人相比,2 型糖尿病患者更容易出现认知能力下降(1.5%)和痴呆(1.6%)。尽管认知功能障碍对 2 型糖尿病(T2DM)患者有不利影响,但它却是 T2DM 患者最不容易处理的并发症。研究目的本研究试图探讨 T2DM 患者在练习瑜伽 12 周后认知能力的变化以及导致这些变化的可能因素。研究方法本研究是一项平行分组随机对照试验,比较了随机分为瑜伽组(YG)(25 人)和等待对照组(29 人)的参与者的结果。研究评估了干预前后Stroop任务后的N200和N450事件相关电位(ERP)成分、心率变异性(HRV)和HbA1c。结果显示干预后,N200 ERP分量的平均振幅显示出显著的组间差异,表明神经在冲突监控和反应抑制过程中的效率有所提高。N450分量没有差异。T2DM 患者在练习瑜伽后心率降低,平均心率增加,而其他心率变异参数没有相应变化,这表明心脏活动得到了整体改善。此外,瑜伽练习还降低了 T2DM 患者的 HbA1c 水平,表明血糖控制得到了改善。此外,干预后 HbA1c 水平与反应时间呈负相关,表明血糖控制对认知能力有影响。结论为期 12 周的瑜伽练习通过增强冲突监控和反应抑制过程改善了认知能力。此外,干预后认知能力的提高还得益于血糖控制的改善。
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引用次数: 0
Impaired Visual Inhibition in Amnestic Mild Cognitive Impairment. 失忆性轻度认知障碍患者的视觉抑制能力受损
IF 2 4区 医学 Q2 Medicine Pub Date : 2024-05-01 Epub Date: 2022-11-03 DOI: 10.1177/15500594221136856
Gionata Strigaro, Benedetta Gori, Clara Zoccola, Alessandro Vinassa, Federica Cattaneo, Gianluca Avino, Paolo Barbero, Claudia Varrasi, Roberto Cantello

Objective.The pathophysiology of amnestic mild cognitive impairment (aMCI) and Alzheimer disease (AD) is still a matter of debate. Visual system might be precociously altered, especially for its cholinergic connections. We thus studied patients with aMCI compared to AD with paired-pulse flash-visual evoked potentials (paired-F-VEPs), a putative marker of cholinergic function. Methods. We enrolled 12 adult patients with aMCI and 12 with AD. 14 normal age- and sex-matched subjects acted as controls (HS). Stimuli were single flashes, with interspersed random flash pairs at critical interstimulus intervals (ISIs, 16.5 to 125 ms) with closed eyes. The "single" (unconditioned) F-VEP was split into a "main complex" (50 to 200 ms after the flash) and a "late response" (200 to 400 ms). As for paired stimulation, the "test" F-VEP emerged from electronic subtraction of the "single" F-VEP from the "paired"-F-VEP. Results. In the single F-VEP, P2 latency was prolonged in patients (aMCI and AD) compared to HS (p < .05). As to the paired F-VEPs, in aMCI the "late response" normal inhibition was abolished at ISIs 50-62.5 ms (p ≤ .016), compared to AD and controls. No changes were detected for the "main complex". Conclusions. Paired-F-VEPs demonstrate a defective neural inhibition in the visual system of patients with aMCI at critical intervals. It may represent a compensatory mechanism against neuronal loss, the failure of which may be involved in AD development. Paired-F-VEPs may warrant inclusion in future preclinical/clinical studies, to evaluate its potential role in the pathophysiology and management of aMCI.

目的:关于失忆性轻度认知障碍(aMCI)和阿尔茨海默病(AD)的病理生理学仍存在争议。视觉系统可能提前发生改变,尤其是其胆碱能连接。因此,我们利用成对脉冲闪光视觉诱发电位(paired-pulse flash-visual evoked potentials,Paired-F-VEPs)--一种胆碱能功能的假定标志物--研究了轻度认知功能障碍(amnestic mild cognitive impairment,MCI)和阿尔茨海默病(Alzheimer disease,AD)患者。研究方法我们招募了 12 名 aMCI 和 12 名 AD 成年患者。14名年龄和性别匹配的正常人作为对照组(HS)。刺激物为单个闪光,并在闭眼状态下以临界刺激间隔(ISI,16.5 至 125 毫秒)穿插随机闪光对。单次"(无条件)F-VEP 被分为 "主复合"(闪光后 50 至 200 毫秒)和 "晚期反应"(200 至 400 毫秒)。至于配对刺激,"测试 "F-VEP 是通过电子方式从 "配对 "F-VEP 中减去 "单一 "F-VEP 而得出的。结果。在单一 F-VEP 中,与 HS 相比,患者(aMCI 和 AD)的 P2 潜伏期延长(p p ≤ .016),与 AD 和对照组相比也是如此。主复合体 "未发现任何变化。结论成对的F-VEPs显示,aMCI患者的视觉系统在关键时间间隔内存在神经抑制缺陷。这可能是对神经元缺失的一种补偿机制,这种机制的失效可能与注意力缺失症的发展有关。成对 F-VEPs 可能值得纳入未来的临床前/临床研究,以评估其在 aMCI 的病理生理学和治疗中的潜在作用。
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引用次数: 0
Effects of Four Different EEG-Neurofeedback Reinforcement Types in Healthy Individuals - A Pilot Study. 四种不同脑电图-神经反馈强化类型对健康人的影响--一项试点研究。
IF 2 4区 医学 Q2 Medicine Pub Date : 2024-05-01 Epub Date: 2022-11-13 DOI: 10.1177/15500594221138278
Roland Mergl, Susanne Karch, Jennifer Henl, Dorothea Meindl, Felix Schöpf, Szilard I Szabo, Paulina Hallweger, Philipp Heiler, Maximilian Maywald, Nadja Tschentscher, Antje-Kathrin Allgaier, Oliver Pogarell

EEG neurofeedback (EEG-NFB) is a promising tool for the treatment of depressive disorders. However, many methods for the presentation of neurobiological reactions are available and it is widely unknown which of these feedback options are preferrable. Moreover, the influence of motivation on NFB training success is insufficiently studied. This study analyzed the efficacy of a novel EEG protocol (FC3/Pz) based on findings for NFB in depression. The role of four feedback options (Rumination, Anxiety, Meditation Master, Moving Art) from the NFB software "Brain Assistant" and motivation in EEG-based NFB performance was studied. Regarding "Anxiety" and "Rumination" visual feedback was used to evoke emotions; reinforcement (both negative and positive operant conditioning) was continuous. Regarding "Meditation Master" visual feedback was combined with continuous positive reinforcement. Regarding "Moving Art" 20-min calm nature films with neutral character were used; both visual and auditive feedback were applied. The reinforcement was positive and continuous. 13 healthy participants completed 15 EEG sessions over four months combining simultaneous frontal (aims: reduction of theta-, alpha- and high beta-activity, increase of low and mid beta-activity) and parietal training (aims: reduction of theta-, alpha 1-, mid and high beta-activity, increase of alpha 2- and low beta-activity). We observed significantly more pronounced percentage change in the expected direction for Anxiety than Moving Art (mean difference = 3.32; p = 0.003). The association between motivation and performance was non-significant. Based on these results we conclude that feedback with both negative and positive operant conditioning and emotion evoking effects should be preferred.

脑电图神经反馈(EEG-NFB)是一种治疗抑郁障碍的有效工具。然而,目前有多种方法可用于呈现神经生物学反应,人们普遍不知道这些反馈方法中哪种更可取。此外,动机对 NFB 训练成功与否的影响也未得到充分研究。本研究分析了基于抑郁症 NFB 研究结果的新型脑电图方案(FC3/Pz)的功效。研究了无创脑电图软件 "大脑助手 "的四个反馈选项(反刍、焦虑、冥想大师、移动艺术)和动机在基于脑电图的无创脑电图表现中的作用。关于 "焦虑 "和 "反刍",使用了视觉反馈来唤起情绪;强化(消极和积极的操作性条件反射)是连续的。关于 "冥想大师",视觉反馈与持续的正强化相结合。至于 "移动艺术",则使用了 20 分钟的中性自然平静影片;同时使用了视觉和听觉反馈。强化是积极和持续的。13 名健康参与者在四个月内完成了 15 次脑电图训练,同时进行了额叶训练(目的:降低θ、α和高贝塔活性,提高中低贝塔活性)和顶叶训练(目的:降低θ、α1、中和高贝塔活性,提高α2 和低贝塔活性)。我们观察到,在预期方向上,"焦虑 "的百分比变化明显高于 "感动艺术"(平均差异 = 3.32;P = 0.003)。动机与成绩之间的关系不显著。基于这些结果,我们得出结论,应首选同时具有消极和积极操作性条件反射和情绪诱发效应的反馈。
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引用次数: 0
Transcranial Alternating Current Stimulation Alters Auditory Steady-State Oscillatory Rhythms and Their Cross-Frequency Couplings. 经颅交流电刺激改变听觉稳态振荡节律及其跨频耦合。
IF 2 4区 医学 Q2 Medicine Pub Date : 2024-05-01 Epub Date: 2023-06-12 DOI: 10.1177/15500594231179679
Sara de la Salle, Joëlle Choueiry, Mark Payumo, Matt Devlin, Chelsea Noel, Ali Abozmal, Molly Hyde, Renée Baysarowich, Brittany Duncan, Verner Knott

Auditory cortical plasticity deficits in schizophrenia are evidenced with electroencephalographic (EEG)-derived biomarkers, including the 40-Hz auditory steady-state response (ASSR). Aiming to understand the underlying oscillatory mechanisms contributing to the 40-Hz ASSR, we examined its response to transcranial alternating current stimulation (tACS) applied bilaterally to the temporal lobe of 23 healthy participants. Although not responding to gamma tACS, the 40-Hz ASSR was modulated by theta tACS (vs sham tACS), with reductions in gamma power and phase locking being accompanied by increases in theta-gamma phase-amplitude cross-frequency coupling. Results reveal that oscillatory changes induced by frequency-tuned tACS may be one approach for targeting and modulating auditory plasticity in normal and diseased brains.

精神分裂症患者的听觉皮质可塑性缺陷可通过脑电图(EEG)得出的生物标志物得到证实,其中包括 40 赫兹听觉稳态反应(ASSR)。为了了解导致 40 赫兹听觉稳态反应的潜在振荡机制,我们研究了它对双侧颞叶经颅交变电流刺激(tACS)的反应。虽然 40-Hz ASSR 对伽马经颅交变电流刺激没有反应,但它受到了θ经颅交变电流刺激(与假经颅交变电流刺激相比)的调节,伽马功率和相位锁定的降低伴随着θ-伽马相位-振幅跨频耦合的增加。研究结果表明,频率调谐的 tACS 诱导的振荡变化可能是针对和调节正常和患病大脑听觉可塑性的一种方法。
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引用次数: 0
EEG Characteristics Before and After Dexmedetomidine Treatment in Severe Patients: A Prospective Study. 重症患者右美托咪定治疗前后的脑电图特征:一项前瞻性研究
IF 2 4区 医学 Q2 Medicine Pub Date : 2024-05-01 Epub Date: 2022-12-20 DOI: 10.1177/15500594221144570
Yujie Ma, Hongbin Zhang, Jijia Bai, Jinyuan Zhu

Background. Bedside electroencephalography (EEG) can monitor the changes in brain function in critical patients. Light sedation is recommended in intensive care unit (ICU) patients, but sedation might confuse the EEG readings. There are few studies on the changes of EEG in severe patients with dexmedetomidine. This study aimed to explore the EEG characteristics before and after dexmedetomidine in severe patients in the ICU. Methods. This prospective study enrolled severe patients with sepsis who needed light sedation, we sedated the patients with dexmedetomidine. EEG was recorded for at least 60 min using a quantitative EEG (qEEG) bedside monitor. Amplitude-EEG (aEEG), relative spectral energy, alpha variation, and spectral entropy were recorded and compared before/after dexmedetomidine. Results. Sixty-three participants were enrolled. The relative spectral energy and alpha variation were not different before and after the use of dexmedetomidine (P> .05). The amplitude of the upper and lower boundaries in aEEG and spectral entropy were significantly lower after light sedation with dexmedetomidine compared with before (P< .05). When grouped according to the Glasgow Coma Scale (GCS), the amplitude of qEEG in participants with moderate GCS decreased significantly(P< .05), but not in mild or severe GCS. Conclusion. Relative spectral energy and alpha variation derived from qEEG could be used to evaluate the state of brain function even under light sedation with dexmedetomidine in severe patients during their ICU stay.

背景。床旁脑电图(EEG)可监测危重病人脑功能的变化。重症监护室(ICU)患者建议使用轻度镇静剂,但镇静剂可能会混淆脑电图读数。有关使用右美托咪定治疗重症患者脑电图变化的研究很少。本研究旨在探讨重症监护室重症患者使用右美托咪定前后的脑电图特征。方法。这项前瞻性研究招募了需要轻度镇静的重症脓毒症患者,我们使用右美托咪定对患者进行镇静。使用定量脑电图(qEEG)床旁监护仪记录至少 60 分钟的脑电图。记录并比较右美托咪定使用前后的振幅脑电图(aEEG)、相对频谱能量、α变异和频谱熵。结果。63 名参与者参加了研究。使用右美托咪定前后,相对频谱能量和阿尔法变化没有差异(P > .05)。使用右美托咪定进行轻度镇静后,aEEG 上下界振幅和频谱熵明显低于使用前(P .05)。根据格拉斯哥昏迷量表(GCS)分组时,中度 GCS 参与者的 qEEG 振幅明显下降(P .05),而轻度或重度 GCS 参与者的 qEEG 振幅则没有下降。结论即使在使用右美托咪定进行轻度镇静的情况下,重症患者在入住重症监护室期间的脑功能状态也可通过 qEEG 得出的相对频谱能量和α变异进行评估。
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引用次数: 0
Proactive and Reactive Inhibitory Control Strategies: Exploring the Impact of Interindividual Variables on an ERP Continuous Performance Task (AX-CPT). 前瞻性和反应性抑制控制策略:探索个体间变量对ERP连续表现任务(AX-CPT)的影响。
IF 2 4区 医学 Q2 Medicine Pub Date : 2024-05-01 Epub Date: 2022-12-22 DOI: 10.1177/15500594221145905
Elisa Schröder, Anais Ingels, Alexandru Dumitrescu, Charles Kornreich, Salvatore Campanella

According to the Dual Mechanisms of Control (DMC) framework, cognitive control can be divided into two strategies: proactive cognitive control, which relies mainly on the active maintenance of contextual information relevant to the ongoing task; and reactive cognitive control, which is a form of transient control triggered by an external cue. Although cognitive control has been studied extensively, little is known about the specificities of inhibition within the framework of the DMC model and the influence of interindividual variables on inhibitory control.Thanks to an inhibitory version of the continuous performance task (CPT), we studied behavioral performances and Event-Related Potentials (ERPs) related to proactive and reactive inhibition, and their links to psychological profile and cognitive performances. One hundred and five young adults underwent the task, along with a short clinical and cognitive evaluation.We were able to observe ERPs related to proactive (cue-N1, cue-N2, cue-P3, and the contingent negative variation) and reactive inhibitory control (target-N2 and target-P3). Our results showed that proactive strategies appeared to be linked with impulsivity, working memory abilities, dominant response inhibition, gender, and the consumption pattern of nicotine. Reactive strategies appeared to be linked with attentional and working memories abilities.Overall, the inhibitory AX-CPT allowed a specific investigation of cognitive control within the framework of the DMC based on behavioral and ERP variables. This provided us an opportunity to investigate the principal ERP components related to proactive and reactive inhibitory control strategies as well as to link them with specific clinical and cognitive variables.

根据 "双重控制机制"(DMC)框架,认知控制可分为两种策略:主动认知控制和被动认知控制。前者主要依赖于主动保持与当前任务相关的情境信息;后者则是一种由外部线索触发的瞬时控制形式。尽管认知控制已被广泛研究,但人们对 DMC 模型框架内抑制的特异性以及个体间变量对抑制控制的影响却知之甚少。借助抑制性版本的连续表现任务(CPT),我们研究了与主动和反应性抑制相关的行为表现和事件相关电位(ERP),以及它们与心理状况和认知表现的联系。我们能够观察到与主动(提示-N1、提示-N2、提示-P3和或然负变异)和反应性抑制控制(目标-N2和目标-P3)相关的ERPs。我们的研究结果表明,主动策略似乎与冲动、工作记忆能力、优势反应抑制、性别和尼古丁消费模式有关。总之,抑制性 AX-CPT 可以根据行为和 ERP 变量,在 DMC 框架内对认知控制进行具体研究。这让我们有机会研究与主动和被动抑制控制策略相关的主要ERP成分,并将它们与特定的临床和认知变量联系起来。
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引用次数: 0
Comparison of Spectral Analysis of Gamma Band Activity During Actual and Imagined Movements as a Cognitive Tool. 将实际运动和想象运动时伽马带活动的频谱分析作为一种认知工具进行比较。
IF 2 4区 医学 Q2 Medicine Pub Date : 2024-05-01 Epub Date: 2023-09-05 DOI: 10.1177/15500594231197100
Jitendra Kumawat, Anuradha Yadav, Kavita Yadav, Kusum Lata Gaur

Background. Imagined motor movement is a cognitive process in which a subject imagines a movement without doing it, which activates similar brain regions as during actual motor movement. Brain gamma band activity (GBA) is linked to cognitive functions such as perception, attention, memory, awareness, synaptic plasticity, motor control, and Imagination. Motor imagery can be used in sports to improve performance, raising the possibility of using it as a rehabilitation method through brain plasticity through mirror neurons. Method. A comparative observational study was conducted on 56 healthy male subjects after obtaining clearance from the Ethics Committee. EEG recordings for GBA were taken for resting, real, and imaginary motor movements and compared. The power spectrum of gamma waves was analyzed using the Kruskal-Wallis test; a p-value <.05 was considered significant. Results. The brain gamma rhythm amplitude was statistically increased during both actual and imaginary motor movement compared to baseline (resting stage) in most of the regions of the brain except the occipital region. There was no significant difference in GBA between real and imaginary movements. Conclusions. Increased gamma rhythm amplitude during both actual and imaginary motor movement than baseline (resting stage) indicating raised brain cognitive activity during both types of movements. There was no potential difference between real and imaginary movements suggesting that the real movement can be replaced by the imaginary movement to enhance work performance through mirror therapy.

背景介绍想象运动是一种认知过程,受试者在不做动作的情况下想象一个动作,这会激活与实际运动时相似的大脑区域。大脑伽马带活动(GBA)与感知、注意力、记忆、意识、突触可塑性、运动控制和想象等认知功能有关。运动想象可用于体育运动,以提高运动成绩,并有可能通过镜像神经元的大脑可塑性将其用作一种康复方法。研究方法在获得伦理委员会批准后,我们对 56 名健康男性受试者进行了比较观察研究。对静息、真实和想象的运动动作进行脑电图记录并进行比较。使用 Kruskal-Wallis 检验分析了伽玛波的功率谱;P 值 结果。据统计,与基线(静息阶段)相比,在实际运动和想象运动时,除枕叶区外,大部分脑区的脑伽马节律振幅都有所增加。实际运动和想象运动之间的伽马节律无明显差异。结论与基线(静息阶段)相比,实际运动和想象运动时的伽马节律振幅都有所增加,这表明这两种运动时大脑的认知活动都有所提高。实际运动和想象运动之间没有潜在的差异,这表明可以通过镜像疗法用想象运动代替实际运动来提高工作表现。
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引用次数: 0
Original Research: Clinical Significance of a Unique Pediatric EEG Configuration: Bi-Frontal Spikes With Simultaneous Bi-Occipital Positivity 原创研究:独特儿科脑电图配置的临床意义:双额叶尖峰与双枕叶同时阳性
IF 2 4区 医学 Q2 Medicine Pub Date : 2024-04-13 DOI: 10.1177/15500594241246505
Jacqueline Crawford, Cassie McFarlane, Anita N Datta
Introduction: Frontal-predominant epileptiform discharges (EDs) include generalized spike-wave (GSW) and frontal spikes (FS). However, negative bi-frontal ED with simultaneous occipital positivity (BFOD) are rare, leading to questions regarding physiological generators. Methods: To determine the clinical significance of BFOD, electroclinical features of children with BFOD (n = 40) were compared to control patients with GSW (n = 102) and FS (n = 100). Results: Results are presented in the following order: BFOD, GSW, and FS. Epilepsy was prevalent among the groups: 95.0%, 90.2%, and 77.0%, respectively. The median age of seizure-onset did not significantly differ between groups: 3.00, 4.00, and 2.25 years, respectively. Regarding EEG background features, the BFOD group had more disorganized sleep architecture than other groups, P < .005. There was a significant difference in the proportion of developmental delay (DD) between the groups ( P < .005). BFOD had much higher odds of DD compared to GSW and FS groups: odds ratio (OR) (confidence interval [CI]) 19.44 [5.64, 64.05] and 3.98 [1.16, 13.34]. Furthermore, BFOD had much higher odds of severe DD compared to GSW and FS groups: 9.60 [2.75, 33.45] and 2.73 [1.03, 7.27]. A Gross Motor Function Classification System (GMFCS) score of ≥ 4 was more prevalent in BFOD (22.5%), than GSW (0%) and FS groups (9%). On neuroimaging, BFOD had more structural ( P < .005) and multilobar structural ( P < .05) abnormalities than control groups. Conclusion: Children with BFOD had particularly severe significant DD, considerable motor deficit (GMFCS ≥ 4), and brain structural abnormalities, often multilobar. This suggests BFOD is a marker of severe underlying brain dysfunction and not benign when encountered on routine EEG review.
简介以额叶为主的癫痫样放电(ED)包括泛化尖波(GSW)和额叶尖波(FS)。然而,双额叶负性放电同时伴有枕叶阳性(BFOD)的情况非常罕见,这就引起了有关生理发生因素的问题。方法:为了确定 BFOD 的临床意义,将 BFOD 儿童(n = 40)的电临床特征与 GSW(n = 102)和 FS(n = 100)的对照组患者进行了比较。结果如下结果按以下顺序排列:BFOD、GSW 和 FS。各组癫痫发病率分别为 95.0%、90.2% 和 77.0%。各组的癫痫发作年龄中位数差异不大:分别为 3.00 岁、4.00 岁和 2.25 岁。在脑电图背景特征方面,BFOD 组的睡眠结构紊乱程度高于其他组,P < .005。各组之间发育迟缓(DD)的比例存在明显差异(P < .005)。与 GSW 组和 FS 组相比,BFOD 患发育迟缓的几率要高得多:几率比(OR)(置信区间 [CI])分别为 19.44 [5.64, 64.05] 和 3.98 [1.16, 13.34]。此外,与 GSW 组和 FS 组相比,BFOD 患严重残疾的几率要高得多:分别为 9.60 [2.75, 33.45] 和 2.73 [1.03, 7.27]。粗大运动功能分级系统(GMFCS)评分≥4分在BFOD(22.5%)中比GSW(0%)和FS组(9%)更普遍。在神经影像学方面,BFOD 比对照组有更多的结构(P < .005)和多叶结构(P < .05)异常。结论患有BFOD的儿童有特别严重的显著DD、相当程度的运动障碍(GMFCS ≥ 4)和脑结构异常,通常为多叶结构异常。这表明 BFOD 是严重潜在脑功能障碍的标志,在常规脑电图检查中并非良性。
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引用次数: 0
Central Auditory Changes Associated with Age-related Hearing Loss 与老年性听力损失有关的中枢听觉变化
IF 2 4区 医学 Q2 Medicine Pub Date : 2024-04-03 DOI: 10.1177/15500594241243116
Selhan Gürkan, Oğuz Başokçu, Serpil Mungan Durankaya, Yalçın İşler, Günay Kırkım
Objective. This study aimed to investigate age-related changes in cortical auditory evoked potentials (CAEPs) while considering three crucial factors: aging, high-frequency hearing loss and sensation level of the CAEP stimulus. Method. The electrophysiological and audiometric data of 71 elderly participants were analyzed using multiple regression analysis to investigate the association of CAEPs with the factors of aging, high-frequency hearing loss and sensation level of the CAEP test stimulus. Results. Aging was significantly associated with prolonged N1 and P2 latencies and reduced P2 amplitude. Elevated thresholds related to the sensation level of the CAEP stimulus were significantly associated with increased N1 and P2 amplitudes and decreased N1 latency. A significant relationship was detected between high-frequency hearing thresholds and the shortening of P2 latencies and the reduction of P2 amplitudes. Conclusion. The results of this study highlight the complex interplay of aging, high-frequency hearing loss and the sensation level of the CAEP stimulus on CAEP components in elderly people. These factors should be considered in future research using CAEPs to enhance overall understanding of auditory processing in the aging population.
研究目的本研究旨在探讨皮层听觉诱发电位(CAEPs)与年龄相关的变化,同时考虑三个关键因素:年龄、高频听力损失和 CAEPs 刺激的感觉水平。研究方法采用多元回归分析法对71名老年参与者的电生理和听力数据进行分析,研究CAEPs与年龄、高频听力损失和CAEP测试刺激感觉水平等因素的关系。结果发现衰老与 N1 和 P2 潜伏期的延长以及 P2 振幅的减小明显相关。与 CAEP 刺激感觉水平相关的阈值升高与 N1 和 P2 振幅增大和 N1 延迟减小明显相关。高频听阈与 P2 潜伏期缩短和 P2 振幅减小之间存在明显关系。结论本研究的结果凸显了衰老、高频听力损失和 CAEP 刺激的感觉水平对老年人 CAEP 成分的复杂相互作用。在今后使用 CAEPs 进行研究时,应考虑这些因素,以加深对老年人听觉处理过程的全面了解。
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引用次数: 0
期刊
Clinical EEG and Neuroscience
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