Leptin is a food intake hormone. Informed leptin diet provides adequate nutrition. Leptin plays an important role in T2DM. Having high leptin and being in love is not a reason for preference. Evaluation of serum and ptin levels in T2DM patients and healthy patients, and the relationship between serum fasting insulin and leptin in T2DM. In the endocrine and market cross-sectional education, a total of 92 serums were studied, including 70 patients with T2DM and 22 patients who were not healthy. Serum leptin was measured by ELISA, serum insulin autoanalyzer Cobas E411. Hemoglobin was studied with HPLC D10. Posting regarding serum leptin and insulin, fasting and BMI. In this study, a significant relationship was observed between leptin and insulin and T2DM, and a significant positive relationship between leptin and insulin (p
{"title":"Study of Serum Leptin Level in Patients DiabetesMellitusType2: in Relation with Insulin Level","authors":"M. Sadeq, A. Sari","doi":"10.7197/cmj.1082096","DOIUrl":"https://doi.org/10.7197/cmj.1082096","url":null,"abstract":"Leptin is a food intake hormone. Informed leptin diet provides adequate nutrition. Leptin plays an important role in T2DM. Having high leptin and being in love is not a reason for preference. Evaluation of serum and ptin levels in T2DM patients and healthy patients, and the relationship between serum fasting insulin and leptin in T2DM. In the endocrine and market cross-sectional education, a total of 92 serums were studied, including 70 patients with T2DM and 22 patients who were not healthy. Serum leptin was measured by ELISA, serum insulin autoanalyzer Cobas E411. Hemoglobin was studied with HPLC D10. Posting regarding serum leptin and insulin, fasting and BMI. In this study, a significant relationship was observed between leptin and insulin and T2DM, and a significant positive relationship between leptin and insulin (p","PeriodicalId":10750,"journal":{"name":"Cumhuriyet medical journal","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73135523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Elif Eği̇lmez, Cemile Zontul, A. Huseynzada, G. Aliyeva, U. Hasanova, A. Taş, Y. Siliğ
Objective: Cancer arises as a result of the failure of the mechanisms controlling normal division in a group of cells. It is known that some new synthesis compounds intended for use in cancer treatment have anti-fungal, anti-bacterial, anti-carcinogenic effects. In this study, it was aimed to apply the newly synthesized B-108 compound to the A-549 cell line and then to investigate the effect of this compound on the ERCC1 gene expression profile. Materials and Methods: Firstly, compound B-108 was synthesized in our study. Afterwards, this synthesized molecule was applied in eight different concentrations (1-100 μg/ml) in A-549 cell line and 3-(4,5-dimethylthiazol-2-yl)-2,5-yl for 24 hours, 48 hours and 72 hours. Anticancer activities were determined using diphenyltetrazolium bromide (MTT) method. Expression level of DNA repair gene (ERCC1) was determined using RT-PCR method. Results: As a result, it was determined that the molecule applied to the A-549 cell line showed the highest activity after 72 hours of incubation. It was observed that the ERCC1 gene expression of the molecule applied on lung cancer was lower than the control group. Discussion: Considering the current study results, low expression of ERCC1 shows that compound B-108 correlates with overall survival on lung cancer cells.
{"title":"INVESTIGATION OF THE EFFECT OF B-108 CONTAINING AZOMETHIN GROUP ON DNA REPAIR GENE","authors":"Elif Eği̇lmez, Cemile Zontul, A. Huseynzada, G. Aliyeva, U. Hasanova, A. Taş, Y. Siliğ","doi":"10.7197/cmj.1189765","DOIUrl":"https://doi.org/10.7197/cmj.1189765","url":null,"abstract":"Objective: Cancer arises as a result of the failure of the mechanisms controlling normal division in a group of cells. It is known that some new synthesis compounds intended for use in cancer treatment have anti-fungal, anti-bacterial, anti-carcinogenic effects. In this study, it was aimed to apply the newly synthesized B-108 compound to the A-549 cell line and then to investigate the effect of this compound on the ERCC1 gene expression profile. \u0000Materials and Methods: Firstly, compound B-108 was synthesized in our study. Afterwards, this synthesized molecule was applied in eight different concentrations (1-100 μg/ml) in A-549 cell line and 3-(4,5-dimethylthiazol-2-yl)-2,5-yl for 24 hours, 48 hours and 72 hours. Anticancer activities were determined using diphenyltetrazolium bromide (MTT) method. Expression level of DNA repair gene (ERCC1) was determined using RT-PCR method. \u0000Results: As a result, it was determined that the molecule applied to the A-549 cell line showed the highest activity after 72 hours of incubation. It was observed that the ERCC1 gene expression of the molecule applied on lung cancer was lower than the control group. \u0000Discussion: Considering the current study results, low expression of ERCC1 shows that compound B-108 correlates with overall survival on lung cancer cells.","PeriodicalId":10750,"journal":{"name":"Cumhuriyet medical journal","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79552129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Efe Taha Bucak, Zuhal Tuncbilek, A. Huseynzada, M. Aghayev, U. Hasanova, A. Taş, Y. Siliğ
Objective: Lung cancer is one of the most common cancers in the world. It is known that angiogenesis plays a role in the development and metastasis of lung cancer. The anticancer properties of azomethine derivatives known as Schiff bases have been demonstrated. In this study, we aimed to determine the anticancer activity of the newly synthesized azomethine derivative compound B-47/2 on lung cancer and to determine the effect of this component on VEGFB gene expression. Material and Method: Compound B-47/2 was synthesized for the first time. B-47/2 compound was applied to lung cancer cell line A549 at varying concentrations (1-100 µg/mL) and its anticancer activity was found after 24, 48 and 72 incubations using the MTT method. The IC50 dose of B-47/2 was applied to the cells and RNA isolation followed by cDNA synthesis was performed. Then, RT-PCR method was used to determine the expression level of VEGF gene. Results: As a result, it was determined that the B-47/2 compound applied to the A-549 cell line showed the highest cytotoxic activity after 72 hours of incubation. In addition, it was determined that the B-47/2 compound decreased the expression of the VEGFB gene. Discussion: There are studies in which the anticancer activity of azomethine derivatives has been observed. The topic of synthesizing new drugs to prevent cancer is popular. We suggested that the newly synthesized component may have anticancer activity and may be effective on angiogenesis.
{"title":"INVESTIGATION OF THE EFFECT OF COMPOUND B-47/2 CONTAINING AZOMETHINE GROUP ON ANGIOGENESIS","authors":"Efe Taha Bucak, Zuhal Tuncbilek, A. Huseynzada, M. Aghayev, U. Hasanova, A. Taş, Y. Siliğ","doi":"10.7197/cmj.1189799","DOIUrl":"https://doi.org/10.7197/cmj.1189799","url":null,"abstract":"Objective: Lung cancer is one of the most common cancers in the world. It is known that angiogenesis plays a role in the development and metastasis of lung cancer. The anticancer properties of azomethine derivatives known as Schiff bases have been demonstrated. In this study, we aimed to determine the anticancer activity of the newly synthesized azomethine derivative compound B-47/2 on lung cancer and to determine the effect of this component on VEGFB gene expression. \u0000Material and Method: Compound B-47/2 was synthesized for the first time. B-47/2 compound was applied to lung cancer cell line A549 at varying concentrations (1-100 µg/mL) and its anticancer activity was found after 24, 48 and 72 incubations using the MTT method. The IC50 dose of B-47/2 was applied to the cells and RNA isolation followed by cDNA synthesis was performed. Then, RT-PCR method was used to determine the expression level of VEGF gene. \u0000Results: As a result, it was determined that the B-47/2 compound applied to the A-549 cell line showed the highest cytotoxic activity after 72 hours of incubation. In addition, it was determined that the B-47/2 compound decreased the expression of the VEGFB gene. \u0000Discussion: There are studies in which the anticancer activity of azomethine derivatives has been observed. The topic of synthesizing new drugs to prevent cancer is popular. We suggested that the newly synthesized component may have anticancer activity and may be effective on angiogenesis.","PeriodicalId":10750,"journal":{"name":"Cumhuriyet medical journal","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81307019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Although the pregnancy period is a physiological process, it can disrupt the sleep pattern and quality with some changes it causes. In this study, it was aimed to determine sleep quality, affecting factors and sleep problems, if any, in pregnant women who applied to our outpatient clinic for follow-up. Materials and Methods: This study, which was designed in a descriptive style, was conducted on 256 pregnant women who applied to the outpatient clinic. The data form included personal information, factors affecting sleep quality, sleep problems and Pittsburg Sleep Quality Index. In addition to descriptive statistics, Mann-Whitney U and Kruskal Wallis tests were used to evaluate the data uploaded to the SPSS program. The error level was set to 0.05. Results: The mean age of the pregnant women was 28.55. It was observed that the mean total PUKI score was 6.27±3.94 (0-18) and the mean sleep duration was 7.5 hours (3-14). Sleep quality was poor in 49.6% of the pregnant women. It was found that the sleep quality of pregnant women was poor in younger than 35 years old (p=0.026), education level of high school and above (p=0.010), who has gender expectetion (p=0.041) and not socially supported (p=0.009). The median weight gain in the third trimester was higher in pregnant women with poor sleep quality (p=0.022). It was determined that musculoskeletal pain, discomfort, frequent urination, swelling in the feet, pain/cramp in the legs and burning in the stomach during pregnancy affected sleep quality negatively. In pregnant women with poor sleep quality; problems such as shortening of sleep duration, difficulty in falling asleep, frequent interruption of sleep, difficulty in falling asleep again, waking up tired in the morning and waking up too early involuntarily were observed more frequently. Conclusion: About half of the pregnant women have poor sleep quality; physical complaints are effective on sleep quality. Sleep quality should be evaluated in all pregnant women and recommendations should be made for sleep hygiene.
{"title":"Evaluation of sleep quality and related factors in pregnant women","authors":"Sanem Nemmezi Karaca, Begum Kurt, Ç. Yıldız","doi":"10.7197/cmj.1176709","DOIUrl":"https://doi.org/10.7197/cmj.1176709","url":null,"abstract":"Objective: Although the pregnancy period is a physiological process, it can disrupt the sleep pattern and quality with some changes it causes. In this study, it was aimed to determine sleep quality, affecting factors and sleep problems, if any, in pregnant women who applied to our outpatient clinic for follow-up. \u0000Materials and Methods: This study, which was designed in a descriptive style, was conducted on 256 pregnant women who applied to the outpatient clinic. The data form included personal information, factors affecting sleep quality, sleep problems and Pittsburg Sleep Quality Index. In addition to descriptive statistics, Mann-Whitney U and Kruskal Wallis tests were used to evaluate the data uploaded to the SPSS program. The error level was set to 0.05. \u0000Results: The mean age of the pregnant women was 28.55. It was observed that the mean total PUKI score was 6.27±3.94 (0-18) and the mean sleep duration was 7.5 hours (3-14). Sleep quality was poor in 49.6% of the pregnant women. It was found that the sleep quality of pregnant women was poor in younger than 35 years old (p=0.026), education level of high school and above (p=0.010), who has gender expectetion (p=0.041) and not socially supported (p=0.009). The median weight gain in the third trimester was higher in pregnant women with poor sleep quality (p=0.022). It was determined that musculoskeletal pain, discomfort, frequent urination, swelling in the feet, pain/cramp in the legs and burning in the stomach during pregnancy affected sleep quality negatively. In pregnant women with poor sleep quality; problems such as shortening of sleep duration, difficulty in falling asleep, frequent interruption of sleep, difficulty in falling asleep again, waking up tired in the morning and waking up too early involuntarily were observed more frequently. \u0000Conclusion: About half of the pregnant women have poor sleep quality; physical complaints are effective on sleep quality. Sleep quality should be evaluated in all pregnant women and recommendations should be made for sleep hygiene.","PeriodicalId":10750,"journal":{"name":"Cumhuriyet medical journal","volume":"68 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88096891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Serum markers, radiological signs, and clinical findings may help guide the assessment of the prognosis of COVID -19 infection. The neutrophil-lymphocyte ratio is a cheap and easily attainable inflammatory marker. This study aims to investigate whether the neutrophil-lymphocyte ratio is associated with the clinical course of the disease in COVID-19 patients with the non-severe disease Materials and Methods: We retrospectively analyzed the results of 189 patients who were followed up at the pandemic clinic of Erciyes University, Medical Faculty Hospital. Patients were categorized according to the criteria released by the Republic of Turkey Ministry of Health. That guide classifies the patients as mild-moderate and severe. Patients over 18 years of age who were treated with COVID-19 and whose symptoms were not severe were included in this study. Patients who have missing data were excluded from this study. Results: The findings showed that there was no significant difference in hospitalized patients concerning neutrophil-lymphocyte ratio levels, white blood cell count, neutrophil count, and lymphocyte count in mild or moderate COVID-19 infected patients at admission and discharge. There was a significant difference in CRP levels between admission and discharge however patients did not progress to a clinical deterioration during the follow-up. Conclusion: Neutrophil-lymphocyte ratio levels did not change significantly between admission and discharge in mild-moderate patients. In light of previous studies reporting that neutrophil-lymphocyte ratio levels are high in patients with severe COVID-19, the present study suggests that neutrophil-lymphocyte ratio levels are a proper marker for predicting the tendency to severe COVID -19 disease in the follow-up of the patients.
{"title":"COVID-19 İnfeksiyonunda Nötrofil-Lenfosit Oranının Prognostik Değeri","authors":"Merve Yildirim, Oktay Bulur","doi":"10.7197/cmj.1149259","DOIUrl":"https://doi.org/10.7197/cmj.1149259","url":null,"abstract":"Objective: Serum markers, radiological signs, and clinical findings may help guide the assessment of the prognosis of COVID -19 infection. The neutrophil-lymphocyte ratio is a cheap and easily attainable inflammatory marker. This study aims to investigate whether the neutrophil-lymphocyte ratio is associated with the clinical course of the disease in COVID-19 patients with the non-severe disease \u0000Materials and Methods: We retrospectively analyzed the results of 189 patients who were followed up at the pandemic clinic of Erciyes University, Medical Faculty Hospital. Patients were categorized according to the criteria released by the Republic of Turkey Ministry of Health. That guide classifies the patients as mild-moderate and severe. Patients over 18 years of age who were treated with COVID-19 and whose symptoms were not severe were included in this study. Patients who have missing data were excluded from this study. \u0000Results: The findings showed that there was no significant difference in hospitalized patients concerning neutrophil-lymphocyte ratio levels, white blood cell count, neutrophil count, and lymphocyte count in mild or moderate COVID-19 infected patients at admission and discharge. There was a significant difference in CRP levels between admission and discharge however patients did not progress to a clinical deterioration during the follow-up. \u0000Conclusion: Neutrophil-lymphocyte ratio levels did not change significantly between admission and discharge in mild-moderate patients. In light of previous studies reporting that neutrophil-lymphocyte ratio levels are high in patients with severe COVID-19, the present study suggests that neutrophil-lymphocyte ratio levels are a proper marker for predicting the tendency to severe COVID -19 disease in the follow-up of the patients.","PeriodicalId":10750,"journal":{"name":"Cumhuriyet medical journal","volume":"74 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72708647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The novel coronavirus disease 2019 (COVID-19) pandemic which emanated from Wuhan city, China and its successive spread across the globe has made a tremendous impact on virtually all spheres of human endeavors; ranging from economy, health, livelihood, and education amongst others. The widespread restrictions currently placed on movement and mass gatherings have made educational and academic activities to be grounded globally. In recent times, the concept of learning has gradually transitioned from traditional classroom methods to online learning where students acquire knowledge through “invisible classrooms”. Most institutions of learning in Africa may encounter difficulties in migrating to this new form of learning due to the lack of information and communications technology (ICT) facilities of international standards. As of today, many students possess internet-enabled devices, yet cannot access the internet as a result of unaffordable data subscription, which has made most learners result in using their devices for non-educational purposes. As the COVID-19 pandemic continues to ravage the African continent, the possibility to re-open our schools remain bleak. Thus, government, authorities, and regulatory bodies in individual countries must improve on their existing ICT infrastructures for a better online learning experience. This paper serves as a wake-up call on Africa and its educational sector to transit to online learning.
{"title":"ONLINE LEARNING DURING COVID-19 PANDEMIC IN AFRICA: A WAKE-UP CALL ON THE EDUCATIONAL SECTOR","authors":"A. Ajagbe, O. Onigbinde, O. Oyeni̇ran, T. Chia","doi":"10.7197/cmj.768072","DOIUrl":"https://doi.org/10.7197/cmj.768072","url":null,"abstract":"The novel coronavirus disease 2019 (COVID-19) pandemic which emanated from Wuhan city, China and its successive spread across the globe has made a tremendous impact on virtually all spheres of human endeavors; ranging from economy, health, livelihood, and education amongst others. The widespread restrictions currently placed on movement and mass gatherings have made educational and academic activities to be grounded globally. In recent times, the concept of learning has gradually transitioned from traditional classroom methods to online learning where students acquire knowledge through “invisible classrooms”. Most institutions of learning in Africa may encounter difficulties in migrating to this new form of learning due to the lack of information and communications technology (ICT) facilities of international standards. As of today, many students possess internet-enabled devices, yet cannot access the internet as a result of unaffordable data subscription, which has made most learners result in using their devices for non-educational purposes. As the COVID-19 pandemic continues to ravage the African continent, the possibility to re-open our schools remain bleak. Thus, government, authorities, and regulatory bodies in individual countries must improve on their existing ICT infrastructures for a better online learning experience. This paper serves as a wake-up call on Africa and its educational sector to transit to online learning.","PeriodicalId":10750,"journal":{"name":"Cumhuriyet medical journal","volume":"53 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88088969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Halil Can KÜÇÜkyildiz, Giray Güneş, F. Koç, Ü. Özüm
Introduction: The co-existence of primary intracranial tumors originating from different cell types is rare. While the association of meningioma and glioma is frequently reported in the literature, the number of cases with meningiomas and epidermoid cysts is relatively low. We report a unique case because the association of supra-sellar meningioma and the epidermoid cyst has not been reported before in the literature. Case Presentation: A 50-year-old female presented to the clinic with a headache and progressive vision loss. In cranial Magnetic Resonance (MR) images, a T1A hypointense, T2A iso-hyper intense heterogenous contrasting suprasellar mass lesion was observed. The patient was operated on with a diagnosis of suprasellar meningioma. At the suprasellar region, a mass that macroscopic view and consistency compatible with epidermoid cyst ex-plored intraoperative incidentally. Two different pathological specimens were sent to pathology. The patient's pathology was reported as WHO 2021, Transitional type grade 1 Meningioma, and Epidermoid cyst content. Conclusion: The number of cases with meningiomas and epidermoid cysts is very low in the literature. Despite advanced MR imaging techniques, cystic lesions can be overlooked in the diagnosis. The occurrence of two different histopathological types of tumors in the same localization can be explained by the local paracrine effects of the tumors.
{"title":"Co-existing Tumors On Suprasellar Region : A Rare Case and Review of Literature","authors":"Halil Can KÜÇÜkyildiz, Giray Güneş, F. Koç, Ü. Özüm","doi":"10.7197/cmj.1072762","DOIUrl":"https://doi.org/10.7197/cmj.1072762","url":null,"abstract":"Introduction: The co-existence of primary intracranial tumors originating from different cell types is rare. While the association of meningioma and glioma is frequently reported in the literature, the number of cases with meningiomas and epidermoid cysts is relatively low. We report a unique case because the association of supra-sellar meningioma and the epidermoid cyst has not been reported before in the literature. \u0000Case Presentation: A 50-year-old female presented to the clinic with a headache and progressive vision loss. In cranial Magnetic Resonance (MR) images, a T1A hypointense, T2A iso-hyper intense heterogenous contrasting suprasellar mass lesion was observed. The patient was operated on with a diagnosis of suprasellar meningioma. At the suprasellar region, a mass that macroscopic view and consistency compatible with epidermoid cyst ex-plored intraoperative incidentally. Two different pathological specimens were sent to pathology. The patient's pathology was reported as WHO 2021, Transitional type grade 1 Meningioma, and Epidermoid cyst content. \u0000Conclusion: The number of cases with meningiomas and epidermoid cysts is very low in the literature. Despite advanced MR imaging techniques, cystic lesions can be overlooked in the diagnosis. The occurrence of two different histopathological types of tumors in the same localization can be explained by the local paracrine effects of the tumors.","PeriodicalId":10750,"journal":{"name":"Cumhuriyet medical journal","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78403403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ABSTRACT CLINICAL FEATURES AND FOLLOW-UP RESULTS OF CHILDREN WITH HYPERTHROIDISM Objective: Hyperthyroidism is a rare clinical condition in childhood that can cause serious problems. Information on the epidemiological features, follow-up and treatment of pediatric patients with hyperthyroidism is quite limited. In this study, clinical and laboratory findings and follow-up results of children with hyperthyroidism are presented. Materials and Methods: The data of children with hyperthyroidism between 2005-2022 at Atatürk University and Erzurum Health Sciences University Pediatric Endocrinology clinics were retrospectively analyzed. Results: 43 (81.1%) female and 10 (18.9%) male patients aged 2-18 years (14.05±3.0) were included in the study. Graves' disease (GD) in 36 (67.9%) patients, Hashimoto's thyroiditis (HT) in 14 (26.4%) patients, subacute thyroiditis in 2 (3.8%) and hyperactive thyroid nodules in 1 (1.9%) were detected. The most common symptoms were palpitations (75.5%), sweating (60.4%), tremors in the hands (49.1%), heat intolerance (45.3%) and weight loss (32.1%). Mean SD values of height, body weight and body mass index at the time of diagnosis were -0.05±1.16, -0.67±1.20 and -0.77±1.25, respectively. Goiter and exophthalmos were present in 69.8% and 30.2% of the cases, respectively. At the time of diagnosis, mean serum thyroid stimulating hormone (TSH), free tri-iodothyronine, free tetra-iodothyronine, thyroglobulin, anti-thyroid peroxidase, anti-thyroglobulin and TSH receptor antibody levels were 0.03±0.09 mIU/L, 13.0.34±7.07 pg/ml, 3.30±1.70 ng/dl, 101.93±180.35 ng/ml, 600.30±858.58 IU/ml, 322.82±644.08 IU/ml, and 12.41 ±14.37 IU/L, respectively. While 42 (79.2%) patients were treated with propranolol and methimazole, 3 (5.7%) patients with propranolol and propylthiouracil, and 4 (7.5%) patients with propranolol, 4 (7.5%) patients were not treated. The mean duration of treatment was 14.67±17.51 months. The mean time to euthyroid after starting antithyroid drug (ATD) was 24.80±14.33 days. While no serious drug-related side effects were detected in any patient, urticaria rash developed in 1 (1.9%) patient in the 1st month of treatment. Total thyroidectomy was performed in 3 cases with GD and 1 case with hyperactive thyroid nodules. Radioactive iodine treatment was not given to any of the cases. The remission rate in patients with GD was 46.7% at the early stage of treatment and 16.7% during the whole follow-up. The recurrence rate was 71.4%. At the last visit, 15 (28.3%) patients were euthyroid, 1 (1.9%) hyperthyroid, and 5 (9.4%) hypothyroid. While 21 (39.6%) of the cases were still using antithyroid medication, 11 (20.8%) were excluded from follow-up. Conclusion: The first and second most common causes of hyperthyroidism in children and adolescents are GH and HT, respectively. TRAb positivity, thyroid scintigraphy findings and clinical follow-up can distinguish between GH and HT. ATD therapy is effective and safe in keeping
{"title":"HİPERTİROİDİZM SAPTANAN ÇOCUKLARIN KLİNİK ÖZELLİKLERİ VE TAKİP SONUÇLARI","authors":"A. Özden, Hakan Döneray","doi":"10.7197/cmj.1115567","DOIUrl":"https://doi.org/10.7197/cmj.1115567","url":null,"abstract":"ABSTRACT \u0000CLINICAL FEATURES AND FOLLOW-UP RESULTS OF CHILDREN WITH HYPERTHROIDISM \u0000Objective: \u0000Hyperthyroidism is a rare clinical condition in childhood that can cause serious problems. Information on the epidemiological features, follow-up and treatment of pediatric patients with hyperthyroidism is quite limited. In this study, clinical and laboratory findings and follow-up results of children with hyperthyroidism are presented. \u0000Materials and Methods: \u0000The data of children with hyperthyroidism between 2005-2022 at Atatürk University and Erzurum Health Sciences University Pediatric Endocrinology clinics were retrospectively analyzed. \u0000Results: \u000043 (81.1%) female and 10 (18.9%) male patients aged 2-18 years (14.05±3.0) were included in the study. Graves' disease (GD) in 36 (67.9%) patients, Hashimoto's thyroiditis (HT) in 14 (26.4%) patients, subacute thyroiditis in 2 (3.8%) and hyperactive thyroid nodules in 1 (1.9%) were detected. The most common symptoms were palpitations (75.5%), sweating (60.4%), tremors in the hands (49.1%), heat intolerance (45.3%) and weight loss (32.1%). Mean SD values of height, body weight and body mass index at the time of diagnosis were -0.05±1.16, -0.67±1.20 and -0.77±1.25, respectively. Goiter and exophthalmos were present in 69.8% and 30.2% of the cases, respectively. At the time of diagnosis, mean serum thyroid stimulating hormone (TSH), free tri-iodothyronine, free tetra-iodothyronine, thyroglobulin, anti-thyroid peroxidase, anti-thyroglobulin and TSH receptor antibody levels were 0.03±0.09 mIU/L, 13.0.34±7.07 pg/ml, 3.30±1.70 ng/dl, 101.93±180.35 ng/ml, 600.30±858.58 IU/ml, 322.82±644.08 IU/ml, and 12.41 ±14.37 IU/L, respectively. While 42 (79.2%) patients were treated with propranolol and methimazole, 3 (5.7%) patients with propranolol and propylthiouracil, and 4 (7.5%) patients with propranolol, 4 (7.5%) patients were not treated. The mean duration of treatment was 14.67±17.51 months. The mean time to euthyroid after starting antithyroid drug (ATD) was 24.80±14.33 days. While no serious drug-related side effects were detected in any patient, urticaria rash developed in 1 (1.9%) patient in the 1st month of treatment. Total thyroidectomy was performed in 3 cases with GD and 1 case with hyperactive thyroid nodules. Radioactive iodine treatment was not given to any of the cases. The remission rate in patients with GD was 46.7% at the early stage of treatment and 16.7% during the whole follow-up. The recurrence rate was 71.4%. At the last visit, 15 (28.3%) patients were euthyroid, 1 (1.9%) hyperthyroid, and 5 (9.4%) hypothyroid. While 21 (39.6%) of the cases were still using antithyroid medication, 11 (20.8%) were excluded from follow-up. \u0000Conclusion: \u0000The first and second most common causes of hyperthyroidism in children and adolescents are GH and HT, respectively. TRAb positivity, thyroid scintigraphy findings and clinical follow-up can distinguish between GH and HT. ATD therapy is effective and safe in keeping ","PeriodicalId":10750,"journal":{"name":"Cumhuriyet medical journal","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90237454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Cervical cancer is one of the most common cancers in women and causes death. Revealing the distribution of HPV prevalence and types in cervical cancer remains important for both treatment and vaccination strategies. The goal of this study is to determine the HPV DNA subtypes of women who are positive for Human Papilloma Virus (HPV) screening, and to evaluate their sociodemographic characteristics and cervical smear results. Methods: The study was conducted on 215 women who were directed to Sivas Cumhuriyet University Obstetry and Gynocology outpatient clinic by her gynocologists or family physicians between 2015-2018 years. A questionnary containing datas of patients about age, education levels and jobs of both spouses, smoking status, obstetric history and age of first sexual intercourse was filled out by the researcher. The data were analysed with SPSS (vers 23.0) program and significance level was taken as 0.05. Results: The most prevalent HPV types were type 16 and category of the others; with the rates of respectively 47% (n: 101), 40% (n: 86). The frequencies of ASCUS (undetermined atypical squamous epithelial cells), LGSIL (low-grade squamous intraepithelial lesion) and HGSIL (high-grade squamous intraepithelial lesion) were respectively found to be 7.9% (n: 17), 23.7% (n: 51) and 1.9% (n: 4). The relationship between HPV types and Pap Smear results was statistically significant (p: 0.011). There was no difference between patients and their spouses about education levels and occupations; and among patients on smoking status, menstrual patterns, age at first sexual intercourse and family planning methods and HPV types (p> 0.05). In women above aged 55, only two types of HPV DNA were observed; which were type 16 and category of the others (p: 0.005). The relationship between abortion history and HPV types was found out to be significant (p: 0.016). Conclusion: This study has contributed to the literature by revealing the types of HPV which observed in Sivas province over a period of 3 years.
{"title":"Assesment Of Hpv Dna Positive İndividuals İn Sivas Province İn Terms Of Some Variables","authors":"Sanem Nemmezi Karaca, Ç. Yıldız","doi":"10.7197/cmj.1176734","DOIUrl":"https://doi.org/10.7197/cmj.1176734","url":null,"abstract":"Background: Cervical cancer is one of the most common cancers in women and causes death. Revealing the distribution of HPV prevalence and types in cervical cancer remains important for both treatment and vaccination strategies. The goal of this study is to determine the HPV DNA subtypes of women who are positive for Human Papilloma Virus (HPV) screening, and to evaluate their sociodemographic characteristics and cervical smear results. \u0000Methods: The study was conducted on 215 women who were directed to Sivas Cumhuriyet University Obstetry and Gynocology outpatient clinic by her gynocologists or family physicians between 2015-2018 years. A questionnary containing datas of patients about age, education levels and jobs of both spouses, smoking status, obstetric history and age of first sexual intercourse was filled out by the researcher. The data were analysed with SPSS (vers 23.0) program and significance level was taken as 0.05. \u0000Results: The most prevalent HPV types were type 16 and category of the others; with the rates of respectively 47% (n: 101), 40% (n: 86). The frequencies of ASCUS (undetermined atypical squamous epithelial cells), LGSIL (low-grade squamous intraepithelial lesion) and HGSIL (high-grade squamous intraepithelial lesion) were respectively found to be 7.9% (n: 17), 23.7% (n: 51) and 1.9% (n: 4). The relationship between HPV types and Pap Smear results was statistically significant (p: 0.011). There was no difference between patients and their spouses about education levels and occupations; and among patients on smoking status, menstrual patterns, age at first sexual intercourse and family planning methods and HPV types (p> 0.05). In women above aged 55, only two types of HPV DNA were observed; which were type 16 and category of the others (p: 0.005). The relationship between abortion history and HPV types was found out to be significant (p: 0.016). \u0000Conclusion: This study has contributed to the literature by revealing the types of HPV which observed in Sivas province over a period of 3 years.","PeriodicalId":10750,"journal":{"name":"Cumhuriyet medical journal","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78642792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Cancer-related deaths in all countries of the world, including our country, come second after deaths caused by cardiovascular diseases. Covid-19 is a pandemic disease affecting many organs but primarily the lung. The aim of this study is to compare the cancer incidences in the pre-Covid-19 period and during Covid-19 pandemic period in Sivas province by means of age, gender and cancer type distribution of the patients. Methods: The population of the study consists of the patients who applied to health institutions in Sivas between 01.11.2018 and 30.06.2021 and were diagnosed as cancer for the first time. The dependent variable of the study is cancer incidence. The independent variable was the 16 monthstime period comprising before Covid-19 pandemic and during the pandemic period seperately. In addition, patients diagnosed with cancer in both periods are evaluated and compared according to age groups, gender and the type of cancer. Results: In this study, the pre-pandemic period and the pandemic period were compared. It was determined that 1355 patients were diagnosed as cancer during the pre-pandemic period and 1720 patients during the pandemic period. The incidence, which was 212.1 per hundred thousand in the previous period, increased to 270.5 per hundred thousand during the 16-month pandemic period. Conclusion: When the data obtained in our study are compared, it is seen that the incidence of cancer increased during the pandemic period compared to the pre-pandemic period.
{"title":"THE EFFECT OF COVID-19 ON THEINCIDENCE OF CANCER IN AMIDDLE ANATOLIAN CITY IN TURKEY","authors":"Serkan Çeli̇kgün, Tulay Koc, R. Ucku","doi":"10.7197/cmj.1171410","DOIUrl":"https://doi.org/10.7197/cmj.1171410","url":null,"abstract":"Objective: Cancer-related deaths in all countries of the world, including our country, come second after deaths caused by cardiovascular diseases. Covid-19 is a pandemic disease affecting many organs but primarily the lung. The aim of this study is to compare the cancer incidences in the pre-Covid-19 period and during Covid-19 pandemic period in Sivas province by means of age, gender and cancer type distribution of the patients. \u0000Methods: The population of the study consists of the patients who applied to health institutions in Sivas between 01.11.2018 and 30.06.2021 and were diagnosed as cancer for the first time. The dependent variable of the study is cancer incidence. The independent variable was the 16 monthstime period comprising before Covid-19 pandemic and during the pandemic period seperately. In addition, patients diagnosed with cancer in both periods are evaluated and compared according to age groups, gender and the type of cancer. \u0000Results: In this study, the pre-pandemic period and the pandemic period were compared. It was determined that 1355 patients were diagnosed as cancer during the pre-pandemic period and 1720 patients during the pandemic period. The incidence, which was 212.1 per hundred thousand in the previous period, increased to 270.5 per hundred thousand during the 16-month pandemic period. \u0000Conclusion: When the data obtained in our study are compared, it is seen that the incidence of cancer increased during the pandemic period compared to the pre-pandemic period.","PeriodicalId":10750,"journal":{"name":"Cumhuriyet medical journal","volume":"360 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76427128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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