Pars planitis (PP) is an idiopathic intermediate uveitis accompanied by snowbanks and snowballs that often affects the pediatric and adolescent age groups. PP accounts for 5-26.7% of pediatric uveitis in different series. Histopathological and clinical findings indicate autoimmune etiology. It shows bilateral and asymmetrical involvement. While patients often complain of blurred vision and floaters, sometimes PP can be asymptomatic. Complications develop as a result of chronic involvement. Diagnosis is made by clinical examination and imaging methods. Treatment aims to suppress inflammation in the acute period and to reduce the frequency, severity and complications of exacerbations in the long term. The ultimate goal is to prevent ocular morbidity by providing complete remission. Conventional treatments include corticosteroids and immunomodulatory (IMT) agents such as methotrexate (MTX), azathioprine (AZA), cyclosporine A (CSA), mycophenolate mofetil (MFM). In recent years, new treatment options including biological agents such as anti-TNF-α therapy have become widespread and are used effectively in treatment. The most important point regarding the necessity of surgical treatment is that surgical success depends on the complete suppression of ocular inflammation with medical treatment. Therefore, it must be ensured that full inflammation control is achieved before surgery. Pars planit (PP) sıklıkla pediatrik ve adölesan yaş grubunu etkileyen snowbank ve snowball’ların eşlik ettiği idiyopatik intermediate üveittir. PP farklı serilerde pediatrik üveitlerin %5-26,7'sini oluşturmaktadır. Histopatolojik ve klinik bulgular otoimmün etiyolojiye işaret eder. Bilateral, asimetrik tutulum gösterir. Hastalar sıklıkla bulanık görme ve uçuşma şikayetiyle başvurur. Bazen de asemptomatik seyreder. Kronik tutulum sonucu komplikasyon gelişimine rastlanabilir. Tanı klinik muayene ve görüntüleme yöntemleriyle konur. Tedavinin amacı akut dönemde enflamasyonu baskılamak, uzun dönemde ise atakların sıklığını, şiddetini ve komplikasyonları azaltmaktır. Nihai amaç, tam bir remisyon sağlanarak oküler morbiditenin önlenmesidir. Geleneksel tedaviler arasında steroitler ve metotreksat (MTX), azatioprin (AZA), siklosporin A (CSA), mikofenolat mofetil (MFM) gibi immunomodülatuar (İMT) ajanlar bulunmaktadır. Son yıllarda; anti-TNF-α tedavisi gibi biyolojik ajanları kapsayan yeni tedavi seçenekleri yaygınlaşmış olup tedavide etkin şekilde kullanılmaktadır. Cerrahi tedavi gerektiğinde ise dikkat edilmesi gereken en önemli nokta; cerrahi başarının oküler enflamasyonun medikal tedavi ile tamamen baskılanmasına bağlı olduğudur. Bu nedenle cerrahi öncesi tam enflamasyon kontrolü sağlandığından emin olunmalıdır.
{"title":"Pars Planitis Epidemiology, Diagnosis, Follow-Up And Prognosis","authors":"Merve Bahar","doi":"10.7197/cmj.1386749","DOIUrl":"https://doi.org/10.7197/cmj.1386749","url":null,"abstract":"Pars planitis (PP) is an idiopathic intermediate uveitis accompanied by snowbanks and snowballs that often affects the pediatric and adolescent age groups. PP accounts for 5-26.7% of pediatric uveitis in different series. Histopathological and clinical findings indicate autoimmune etiology. It shows bilateral and asymmetrical involvement. While patients often complain of blurred vision and floaters, sometimes PP can be asymptomatic. Complications develop as a result of chronic involvement. Diagnosis is made by clinical examination and imaging methods. Treatment aims to suppress inflammation in the acute period and to reduce the frequency, severity and complications of exacerbations in the long term. The ultimate goal is to prevent ocular morbidity by providing complete remission. Conventional treatments include corticosteroids and immunomodulatory (IMT) agents such as methotrexate (MTX), azathioprine (AZA), cyclosporine A (CSA), mycophenolate mofetil (MFM). In recent years, new treatment options including biological agents such as anti-TNF-α therapy have become widespread and are used effectively in treatment. The most important point regarding the necessity of surgical treatment is that surgical success depends on the complete suppression of ocular inflammation with medical treatment. Therefore, it must be ensured that full inflammation control is achieved before surgery. Pars planit (PP) sıklıkla pediatrik ve adölesan yaş grubunu etkileyen snowbank ve snowball’ların eşlik ettiği idiyopatik intermediate üveittir. PP farklı serilerde pediatrik üveitlerin %5-26,7'sini oluşturmaktadır. Histopatolojik ve klinik bulgular otoimmün etiyolojiye işaret eder. Bilateral, asimetrik tutulum gösterir. Hastalar sıklıkla bulanık görme ve uçuşma şikayetiyle başvurur. Bazen de asemptomatik seyreder. Kronik tutulum sonucu komplikasyon gelişimine rastlanabilir. Tanı klinik muayene ve görüntüleme yöntemleriyle konur. Tedavinin amacı akut dönemde enflamasyonu baskılamak, uzun dönemde ise atakların sıklığını, şiddetini ve komplikasyonları azaltmaktır. Nihai amaç, tam bir remisyon sağlanarak oküler morbiditenin önlenmesidir. Geleneksel tedaviler arasında steroitler ve metotreksat (MTX), azatioprin (AZA), siklosporin A (CSA), mikofenolat mofetil (MFM) gibi immunomodülatuar (İMT) ajanlar bulunmaktadır. Son yıllarda; anti-TNF-α tedavisi gibi biyolojik ajanları kapsayan yeni tedavi seçenekleri yaygınlaşmış olup tedavide etkin şekilde kullanılmaktadır. Cerrahi tedavi gerektiğinde ise dikkat edilmesi gereken en önemli nokta; cerrahi başarının oküler enflamasyonun medikal tedavi ile tamamen baskılanmasına bağlı olduğudur. Bu nedenle cerrahi öncesi tam enflamasyon kontrolü sağlandığından emin olunmalıdır.","PeriodicalId":10750,"journal":{"name":"Cumhuriyet medical journal","volume":"22 41","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139155980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In history, the greatest aspiration of people is that all humanity has equal rights regardless of race, language, religion or gender. Gender inequality seen in communities where patriarchal structure prevails has caused women to be deprived of their rights. The exclusion of women who have been deprived of their rights due to their gender and even exposure to violence is a global problem that continues from past to present. Violence against women, which is as old as the history of humanity, is a phenomenon that affects all societies deeply and negatively. As a fundamental human rights and freedom problem, it continues to exist all over the World as a universal public health problem, regardless of ethnic origin, class, religion, social status, culture, economic and geographical boundaries. Domestic violence is the most common form of violence against women. In this study, the historical process of women and their rights, the place of women in society today, the historical process of violence against women, the causes and types of violence against women, femicides, the end point of violence against women, the effects of violence on public health, violence in our country will be discussed. Furthermore, institutions and organizations that women victims of violence can apply to, and suggestions against violence towards women are mentioned.
{"title":"PAST AND PRESENT OF WOMEN'S RIGHTS AND VIOLENCE AGAINST WOMEN","authors":"Ali Yildirim, Ersin Biyik","doi":"10.7197/cmj.1388149","DOIUrl":"https://doi.org/10.7197/cmj.1388149","url":null,"abstract":"In history, the greatest aspiration of people is that all humanity has equal rights regardless of race, language, religion or gender. Gender inequality seen in communities where patriarchal structure prevails has caused women to be deprived of their rights. The exclusion of women who have been deprived of their rights due to their gender and even exposure to violence is a global problem that continues from past to present. Violence against women, which is as old as the history of humanity, is a phenomenon that affects all societies deeply and negatively. As a fundamental human rights and freedom problem, it continues to exist all over the World as a universal public health problem, regardless of ethnic origin, class, religion, social status, culture, economic and geographical boundaries. Domestic violence is the most common form of violence against women. In this study, the historical process of women and their rights, the place of women in society today, the historical process of violence against women, the causes and types of violence against women, femicides, the end point of violence against women, the effects of violence on public health, violence in our country will be discussed. Furthermore, institutions and organizations that women victims of violence can apply to, and suggestions against violence towards women are mentioned.","PeriodicalId":10750,"journal":{"name":"Cumhuriyet medical journal","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139159032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background and aim: Coronary artery disease (CAD) and myocardial infarction (MI) are cardiovascular diseases that occur due to atherosclerosis (plaque formation) or atherosclerotic obstruction of the coronary arteries. Their genetic basis has been under investigation for a long time, and common variant studies link different genetic loci with these diseases. In this study, we investigated the possible association of coronary artery disease and myocardial infarction with thrombophilic gene variants, including MTHFR C677T and A1298C, Beta fibrinogen -455G/A, Factor XIIIV34L and PAI-1 4G/5G single nucleotide polymorphisms (SNPs). Methods: A total of 128 people (64 patients and 64 controls) were included in the study. Genomic DNA was isolated using the EZ1 blood mini kit. The DNA was amplified and PCR was performed using the PyroMark PCR Kit (Qiagen, Germany). Pyrosequencing reaction was completed by processing with PyroMark Q24 instrument. Results: We found that the PAI-1 4G/5G polymorphism and the 4G allele were significantly associated with coronary artery disease and myocardial infarction (P= 0.01). Although mutant variants were higher in patients, no statistically significant difference was observed between the patient and control groups in terms of FXIII, Beta-fibrinogen and MTHFR variants. Conclusions: It is clear that the PAI-1 4G allele and the 4G/4G genotype have a significant contribution to the development of coronary artery disease and ultimately myocardial infarction. Prophylactic treatment should be considered in patients with this variant.
{"title":"Thrombophilic gene variants in patients with coronary artery disease and myocardial infarction","authors":"M. Yıldırım","doi":"10.7197/cmj.1373358","DOIUrl":"https://doi.org/10.7197/cmj.1373358","url":null,"abstract":"Background and aim: Coronary artery disease (CAD) and myocardial infarction (MI) are cardiovascular diseases that occur due to atherosclerosis (plaque formation) or atherosclerotic obstruction of the coronary arteries. Their genetic basis has been under investigation for a long time, and common variant studies link different genetic loci with these diseases. In this study, we investigated the possible association of coronary artery disease and myocardial infarction with thrombophilic gene variants, including MTHFR C677T and A1298C, Beta fibrinogen -455G/A, Factor XIIIV34L and PAI-1 4G/5G single nucleotide polymorphisms (SNPs). Methods: A total of 128 people (64 patients and 64 controls) were included in the study. Genomic DNA was isolated using the EZ1 blood mini kit. The DNA was amplified and PCR was performed using the PyroMark PCR Kit (Qiagen, Germany). Pyrosequencing reaction was completed by processing with PyroMark Q24 instrument. Results: We found that the PAI-1 4G/5G polymorphism and the 4G allele were significantly associated with coronary artery disease and myocardial infarction (P= 0.01). Although mutant variants were higher in patients, no statistically significant difference was observed between the patient and control groups in terms of FXIII, Beta-fibrinogen and MTHFR variants. Conclusions: It is clear that the PAI-1 4G allele and the 4G/4G genotype have a significant contribution to the development of coronary artery disease and ultimately myocardial infarction. Prophylactic treatment should be considered in patients with this variant.","PeriodicalId":10750,"journal":{"name":"Cumhuriyet medical journal","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139159088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This descriptive, cross-sectional, and relationship-seeking study aimed to determine the relationship between postpartum anxiety and maternal function in mothers with 6-10 weeks old babies. The study was carried out with 258 mothers who were 6-10 weeks postpartum. The data were collected using the Personal Information Form, Postpartum Specific Anxiety Scale (PSAS), and Barkin Index of Maternal Functioning (BIMF). It was determined that the majority of the mothers participating in the study were between the ages of 27-34, high school graduates, not working, having health insurance, having a moderate income, living with a nuclear family, and married for 2-6 years. The majority of mothers had babies who were 8-9 weeks old, had a vaginal delivery, experienced 2-3 pregnancies, had assistance with postpartum care, and received education/information about postpartum care. The mean PSAS score for the mothers was determined to be at a moderate level (83.71±21.71), while the mean BIMF score was above a moderate level (71.49±13.89). It was found that there was a moderate, negative significant relationship between the PSAS total score and the BIMF total score, and it was determined that the level of maternal functioning decreased as postpartum anxiety increased (p
{"title":"THE RELATIONSHIP BETWEEN POSTPARTUM ANXIETY AND MATERNAL FUNCTION IN MOTHERS","authors":"Emine KILIÇ DOĞAN, Busra Cesur","doi":"10.7197/cmj.1380572","DOIUrl":"https://doi.org/10.7197/cmj.1380572","url":null,"abstract":"This descriptive, cross-sectional, and relationship-seeking study aimed to determine the relationship between postpartum anxiety and maternal function in mothers with 6-10 weeks old babies. The study was carried out with 258 mothers who were 6-10 weeks postpartum. The data were collected using the Personal Information Form, Postpartum Specific Anxiety Scale (PSAS), and Barkin Index of Maternal Functioning (BIMF). It was determined that the majority of the mothers participating in the study were between the ages of 27-34, high school graduates, not working, having health insurance, having a moderate income, living with a nuclear family, and married for 2-6 years. The majority of mothers had babies who were 8-9 weeks old, had a vaginal delivery, experienced 2-3 pregnancies, had assistance with postpartum care, and received education/information about postpartum care. The mean PSAS score for the mothers was determined to be at a moderate level (83.71±21.71), while the mean BIMF score was above a moderate level (71.49±13.89). It was found that there was a moderate, negative significant relationship between the PSAS total score and the BIMF total score, and it was determined that the level of maternal functioning decreased as postpartum anxiety increased (p","PeriodicalId":10750,"journal":{"name":"Cumhuriyet medical journal","volume":"9 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139165021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ABSTRACT Introduction: Pilonidal sinus is most often seen in men between the ages of 15-30. It is regarded as a benign condition that most frequently affects the sacrococcygeal area. However, malignant degeneration can occur at a rate of 0.1%. Malignant degeneration patients tend to be older than 50, untreated for a long time, or to have relapsed frequently. Squamous cell carcinoma (SCC) is the most frequent type of cancer to appear on the pilonidal sinus's base. The first course of treatment is surgery. After surgery, local recurrence rates have been estimated at 40%. Adjuvant radiotherapy or chemoradiotherapy has an effect in reducing local recurrence. In this study, we looked at the frequency of cancer and potential risks as well as the value of routine pathological evaluation in patients who underwent pilonidal sinus surgery in our clinic during a ten-year period. Methods: We performed a retrospective analysis of 1070 patients who underwent pilonidal sinus surgery at the Recep Tayyip Erdoan University Training and Research Hospital between January 2012 and June 2022. Results: After a retrospective analysis of 1070 cases, 0.18% (n=2) of them had a malignancy developed on the basis of the pilonidal sinus, and the pathological result of both patients was reported as SCC. Additionally, one patient had histology that revealed tissue from the pilonidal sinus with a high Ki-67 index and significant mitotic activity. The mean age of the two patients with malignancy was 51. Patients with cancer were found to have complained for approximately 20 years. The patient with high Ki-67 index and mitotic activity was 60 years old, and had complaints for about 10-11 years. Conclusion: Pilonidal sinus has a risk of malignancy in patients with long-term existence, multiple recurrences, and those over 50 years of age. Despite the low rates of malignancy in the pilonidal sinus or the advanced age and long-term disease of the patients with malignancy risk, we advocate pathological examination of all specimens. ÖZ: Giriş: Pilonidal sinüs, sıklıkla 15-30 yaş aralığında ve erkeklerde görülmektedir. En sık olarak sakrokoksigeal bölgede görülmekte olup benign bir hastalık olarak kabul edilir. Ancak %0.1 oranında malign dejenerasyon da gelişebilmektedir Malign dejenerasyon saptanan hastaların büyük kısmı 50 yaş üstünde, uzun dönem tedavi olmamış veya birçok kez nüks etmiş vakalardır. Pilonidal sinüs zemininde gelişen malignitelerde en sık olarak squamoz sellüler karsinom (SCC) görülmektedir. Tedavide ise cerrahi ilk seçenektir. Cerrahi sonrası lokal nüks oranları %40 düzeylerinde bildirilmiştir. Lokal nüksü azaltmada adjuvan radyoterapi veya kemoradyoterapinin etkisi vardır. Çalışmamızda, pilonidal sinüs nedeniyle kliniğimizde 10 yıllık bir süreçte opere edilen olgularda, malignite insidansını ile olası riskleri saptamak ve rutin uygulanan patolojik incelemenin değerini gözden geçirmek amaçlanmıştır. Yöntem: Çalışmamızda Ocak 2012- Haziran 2022 tarihleri arası
{"title":"Is a pathological assessment required following pilonidal sinus surgery? 10-year retrospective analysis","authors":"Ali Özdemi̇r, Turker Acehan","doi":"10.7197/cmj.1186517","DOIUrl":"https://doi.org/10.7197/cmj.1186517","url":null,"abstract":"ABSTRACT Introduction: Pilonidal sinus is most often seen in men between the ages of 15-30. It is regarded as a benign condition that most frequently affects the sacrococcygeal area. However, malignant degeneration can occur at a rate of 0.1%. Malignant degeneration patients tend to be older than 50, untreated for a long time, or to have relapsed frequently. Squamous cell carcinoma (SCC) is the most frequent type of cancer to appear on the pilonidal sinus's base. The first course of treatment is surgery. After surgery, local recurrence rates have been estimated at 40%. Adjuvant radiotherapy or chemoradiotherapy has an effect in reducing local recurrence. In this study, we looked at the frequency of cancer and potential risks as well as the value of routine pathological evaluation in patients who underwent pilonidal sinus surgery in our clinic during a ten-year period. Methods: We performed a retrospective analysis of 1070 patients who underwent pilonidal sinus surgery at the Recep Tayyip Erdoan University Training and Research Hospital between January 2012 and June 2022. Results: After a retrospective analysis of 1070 cases, 0.18% (n=2) of them had a malignancy developed on the basis of the pilonidal sinus, and the pathological result of both patients was reported as SCC. Additionally, one patient had histology that revealed tissue from the pilonidal sinus with a high Ki-67 index and significant mitotic activity. The mean age of the two patients with malignancy was 51. Patients with cancer were found to have complained for approximately 20 years. The patient with high Ki-67 index and mitotic activity was 60 years old, and had complaints for about 10-11 years. Conclusion: Pilonidal sinus has a risk of malignancy in patients with long-term existence, multiple recurrences, and those over 50 years of age. Despite the low rates of malignancy in the pilonidal sinus or the advanced age and long-term disease of the patients with malignancy risk, we advocate pathological examination of all specimens. ÖZ: Giriş: Pilonidal sinüs, sıklıkla 15-30 yaş aralığında ve erkeklerde görülmektedir. En sık olarak sakrokoksigeal bölgede görülmekte olup benign bir hastalık olarak kabul edilir. Ancak %0.1 oranında malign dejenerasyon da gelişebilmektedir Malign dejenerasyon saptanan hastaların büyük kısmı 50 yaş üstünde, uzun dönem tedavi olmamış veya birçok kez nüks etmiş vakalardır. Pilonidal sinüs zemininde gelişen malignitelerde en sık olarak squamoz sellüler karsinom (SCC) görülmektedir. Tedavide ise cerrahi ilk seçenektir. Cerrahi sonrası lokal nüks oranları %40 düzeylerinde bildirilmiştir. Lokal nüksü azaltmada adjuvan radyoterapi veya kemoradyoterapinin etkisi vardır. Çalışmamızda, pilonidal sinüs nedeniyle kliniğimizde 10 yıllık bir süreçte opere edilen olgularda, malignite insidansını ile olası riskleri saptamak ve rutin uygulanan patolojik incelemenin değerini gözden geçirmek amaçlanmıştır. Yöntem: Çalışmamızda Ocak 2012- Haziran 2022 tarihleri arası","PeriodicalId":10750,"journal":{"name":"Cumhuriyet medical journal","volume":"48 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139172082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract: The presence of microorganisms in the kidney, collecting system, or bladder with pyuria and clinical symptoms is called Urinary Tract Infection (UTI). UTI is one of the most common diseases in both nosocomial and community-acquired infections and affects millions of people every year. The clinical types of UTI range from cystitis to sepsis. In this study, we aimed to contribute to the literature by comparing the levels of shelterin proteins and agmatine in the serum of patients diagnosed with cystitis, one of the types of UTI, and healthy volunteers without any known medical disorder, and to bring new approaches to issues such as clinical severity, response to treatment, and pathogenesis of the disease. Methods: In this study, 30 individuals diagnosed with cystitis from UTIs and 30 individuals without any systemic disease participated. Serum agmatine levels were measured by a fluorescence detector using the ultra-high-performance liquid chromatography method (UHPLC). Serum shelterin proteins levels were measured using the ELISA method. Results: When the patients and healthy controls were compared, serum Telomeric Repeat Binding Factor2 (TRF2) levels of the patients were found to be lower than the controls; serum agmatine levels were found to be higher than the controls and statistically significant (p0.05). Conclusion: In conclusion, the statistically significant difference in serum TRF2 and agmatine levels between the groups may be associated with oxidative stress. It is thought that the shortening of telomere lengths may be associated with decreased TRF2 levels.
{"title":"ÜRİNER SİSTEM ENFEKSİYONLARINDA SHELTERİN PROTEİNLERİ VE AGMATİN İLİŞKİSİ","authors":"M. Bedi̇r, Sevtap Bakir, A. Engi̇n","doi":"10.7197/cmj.1294625","DOIUrl":"https://doi.org/10.7197/cmj.1294625","url":null,"abstract":"Abstract: The presence of microorganisms in the kidney, collecting system, or bladder with pyuria and clinical symptoms is called Urinary Tract Infection (UTI). UTI is one of the most common diseases in both nosocomial and community-acquired infections and affects millions of people every year. The clinical types of UTI range from cystitis to sepsis. In this study, we aimed to contribute to the literature by comparing the levels of shelterin proteins and agmatine in the serum of patients diagnosed with cystitis, one of the types of UTI, and healthy volunteers without any known medical disorder, and to bring new approaches to issues such as clinical severity, response to treatment, and pathogenesis of the disease. Methods: In this study, 30 individuals diagnosed with cystitis from UTIs and 30 individuals without any systemic disease participated. Serum agmatine levels were measured by a fluorescence detector using the ultra-high-performance liquid chromatography method (UHPLC). Serum shelterin proteins levels were measured using the ELISA method. Results: When the patients and healthy controls were compared, serum Telomeric Repeat Binding Factor2 (TRF2) levels of the patients were found to be lower than the controls; serum agmatine levels were found to be higher than the controls and statistically significant (p0.05). Conclusion: In conclusion, the statistically significant difference in serum TRF2 and agmatine levels between the groups may be associated with oxidative stress. It is thought that the shortening of telomere lengths may be associated with decreased TRF2 levels.","PeriodicalId":10750,"journal":{"name":"Cumhuriyet medical journal","volume":"194 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139179798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Selin ACAR ŞAHAN, B. Karadaş, Semra AYDIN AKFIRAT, Nihat Aydemi̇r, S. Aksun, Yusuf C. Kaplan
This case report is about a false positive ecstasy (MDMA) result in the urine substance abuse screening analysis of a person using the antidepressant drugs bupropion and sertraline with a therapeutic indication. Urine drug and stimulant screening analysis of a 25-year-old male patient who is history of bupropion (300 mg/day) and sertraline (100 mg/day) use, followed in the Amatem polyclinic due to the probation law, was performed with Syva® Emit® II Plus kits and immunoassay method. In order to confirm the ecstasy test, which was positive in the screening analysis, the substance analysis was repeated on the same sample with the gas chromatography sequential mass spectrometry (GC-MS) method and ecstasy was not detected in the confirmation analysis. At the same time, the presence of bupropion and sertraline patient declared to use, was confirmed with the LC-MS-Iontrap device. In conclusion, with this case example, we wanted to highlight the potential interaction of bupropion with the Syva® Emit® II Plus urine ecstasy screening tests, which could lead to false positive results. When positive ecstasy values are detected in the urine samples analyzed with the immunoassay method in patients using bupropion, the final decision should be made after a confirmatory analysis.
本病例报告的内容是，在对一名使用具有治疗适应症的抗抑郁药物安非他酮和舍曲林的患者进行尿液药物滥用筛查分析时，发现摇头丸（摇头丸）结果呈假阳性。一名 25 岁的男性患者曾服用安非他明（300 毫克/天）和舍曲林（100 毫克/天），因缓刑法而在 Amatem 综合诊所接受随访，我们使用 Syva® Emit® II Plus 试剂盒和免疫测定法对他进行了尿液药物和兴奋剂筛查分析。为了确认在筛查分析中呈阳性的摇头丸检测结果，使用气相色谱顺序质谱法（GC-MS）对同一样本再次进行了物质分析，在确认分析中未检测到摇头丸。同时，使用 LC-MS-Iontrap 设备确认了患者申报使用的安非他酮和舍曲林的存在。总之，通过这个案例，我们希望强调安非他酮与 Syva® Emit® II Plus 尿液摇头丸筛查试剂的潜在相互作用，这可能会导致假阳性结果。当使用安非他酮的患者使用免疫测定法分析尿液样本时检测到摇头丸阳性值，应在进行确证分析后做出最终决定。
{"title":"False positive ecstasy (MDMA) urine drug screening test results due to bupropion use: A case report","authors":"Selin ACAR ŞAHAN, B. Karadaş, Semra AYDIN AKFIRAT, Nihat Aydemi̇r, S. Aksun, Yusuf C. Kaplan","doi":"10.7197/cmj.1371692","DOIUrl":"https://doi.org/10.7197/cmj.1371692","url":null,"abstract":"This case report is about a false positive ecstasy (MDMA) result in the urine substance abuse screening analysis of a person using the antidepressant drugs bupropion and sertraline with a therapeutic indication. Urine drug and stimulant screening analysis of a 25-year-old male patient who is history of bupropion (300 mg/day) and sertraline (100 mg/day) use, followed in the Amatem polyclinic due to the probation law, was performed with Syva® Emit® II Plus kits and immunoassay method. In order to confirm the ecstasy test, which was positive in the screening analysis, the substance analysis was repeated on the same sample with the gas chromatography sequential mass spectrometry (GC-MS) method and ecstasy was not detected in the confirmation analysis. At the same time, the presence of bupropion and sertraline patient declared to use, was confirmed with the LC-MS-Iontrap device. In conclusion, with this case example, we wanted to highlight the potential interaction of bupropion with the Syva® Emit® II Plus urine ecstasy screening tests, which could lead to false positive results. When positive ecstasy values are detected in the urine samples analyzed with the immunoassay method in patients using bupropion, the final decision should be made after a confirmatory analysis.","PeriodicalId":10750,"journal":{"name":"Cumhuriyet medical journal","volume":"144 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139182678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Purpose: The aim of this study is to determine the attitudes of nulliparous women toward fertility and childbirth.
Material and Method: The research was carried out as a cross-sectional descriptive method with improbable sampling technique. Recruitment for participation in the study took place with power analysis and consisted of 213 nulliparous women who had never been pregnant before. Data were collected with the Personal Information Form and the Attitudes Toward Fertility and Childbearing Scale.
Findings: 54% of the women are between the ages of 19-26 and the mean age is 26.51±5.19. It was determined that 76.5% of the women were married for 1-3 years and 65.7% of them used contraception. The total score of the Attitudes Towards Fertility and Childbearing Scale is 69.54±8.28, and the mean subscale score current obstacle 21.57±7.08; importance in the future 28.42±4.63; female identity is 19.55±3.82. It has been determined that women have a positive attitude to fertility and childbearing. In comparison with the total score of the scale and the variables, it was determined that there was a significant difference between variables of age, occupation status, spouse's age, spouse's occupation status, spouse's smoking status, consanguineous marriage, family type, financial status, spouse's age at marriage and mean value of total scale score.
Result: The fact that nulliparous women's attitudes to fertility and childbearing are affected by many factors such as age, occupation status, spouse's age shows that there are many variables that should be considered during the evaluation of nulliparous women by midwives. It is very important for pregnancy planning that women in the preconceptional period have positive attitudes to fertility and childbearing.
{"title":"INVESTIGATION OF NULLIPAROUS WOMEN'S ATTITUDES TOWARD FERTILITY AND CHILDBEARING","authors":"Mustafa Hakan ACER, Hilal ÖZBEK, Demet ÇAKIR","doi":"10.7197/cmj.1345351","DOIUrl":"https://doi.org/10.7197/cmj.1345351","url":null,"abstract":"Purpose: The aim of this study is to determine the attitudes of nulliparous women toward fertility and childbirth.
 Material and Method: The research was carried out as a cross-sectional descriptive method with improbable sampling technique. Recruitment for participation in the study took place with power analysis and consisted of 213 nulliparous women who had never been pregnant before. Data were collected with the Personal Information Form and the Attitudes Toward Fertility and Childbearing Scale.
 Findings: 54% of the women are between the ages of 19-26 and the mean age is 26.51±5.19. It was determined that 76.5% of the women were married for 1-3 years and 65.7% of them used contraception. The total score of the Attitudes Towards Fertility and Childbearing Scale is 69.54±8.28, and the mean subscale score current obstacle 21.57±7.08; importance in the future 28.42±4.63; female identity is 19.55±3.82. It has been determined that women have a positive attitude to fertility and childbearing. In comparison with the total score of the scale and the variables, it was determined that there was a significant difference between variables of age, occupation status, spouse's age, spouse's occupation status, spouse's smoking status, consanguineous marriage, family type, financial status, spouse's age at marriage and mean value of total scale score.
 Result: The fact that nulliparous women's attitudes to fertility and childbearing are affected by many factors such as age, occupation status, spouse's age shows that there are many variables that should be considered during the evaluation of nulliparous women by midwives. It is very important for pregnancy planning that women in the preconceptional period have positive attitudes to fertility and childbearing.","PeriodicalId":10750,"journal":{"name":"Cumhuriyet medical journal","volume":"62 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135579478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In this study, it was aimed to determine the in vitro effect of the extract obtained from mature broccoli on the breast cancer cell line. MDA-MB231 breast cancer cell line was used in the study. MDA-MB-231 cells were exposed to broccoli extract at 37°C and 5% CO2 for varying durations (24 and 48 hours) and doses (125 and 250 µl/ml).At the end of the incubation period, viability, apoptosis, cell cycle and AgNOR protein status of MDA-MB-231 cells were examined in the Muse Cell Analyzer. In the groups containing broccoli extract, a decrease in the percentage of viable cells and a significant increase in the percentage of early and total apoptosis were observed for both doses compared to the control. In the cell cycle test, the number of cells in the S phase increased in all groups.It was observed that the groups containing broccoli extract slowed down the cell cycle in the transition to the S checkpoint. AgNOR staining results also supported cell cycle and apopitosis, and AgNOR number and TAA/NA ratio decreased in the 125 µl/ml broccoli extract group after 24-48 hours and were found to be statistically significant compared to the control group. It was determined that broccoli increased apoptosis on breast cancer cells by various mechanisms and inhibited cell viability/cell growth. The results were similar to the results of AgNOR protein synthesis. The study showed that the regular and correct consumption of broccoli could be effective in preventing cancer formation and slowing its progression.
{"title":"Does broccoli (brassica oleracea var. italica) extract have a potential therapeutic targets on human breast cancer (MDA-MB-231) using AgNOR detection method?","authors":"Gözde ÇOBANOĞLU, Mustafa NİSARİ, Mehtap NİSARİ, Sümeyye UÇAR, Gülderen KEREK, Neriman İNANÇ","doi":"10.7197/cmj.1297877","DOIUrl":"https://doi.org/10.7197/cmj.1297877","url":null,"abstract":"In this study, it was aimed to determine the in vitro effect of the extract obtained from mature broccoli on the breast cancer cell line. MDA-MB231 breast cancer cell line was used in the study. MDA-MB-231 cells were exposed to broccoli extract at 37°C and 5% CO2 for varying durations (24 and 48 hours) and doses (125 and 250 µl/ml).At the end of the incubation period, viability, apoptosis, cell cycle and AgNOR protein status of MDA-MB-231 cells were examined in the Muse Cell Analyzer. In the groups containing broccoli extract, a decrease in the percentage of viable cells and a significant increase in the percentage of early and total apoptosis were observed for both doses compared to the control. In the cell cycle test, the number of cells in the S phase increased in all groups.It was observed that the groups containing broccoli extract slowed down the cell cycle in the transition to the S checkpoint. AgNOR staining results also supported cell cycle and apopitosis, and AgNOR number and TAA/NA ratio decreased in the 125 µl/ml broccoli extract group after 24-48 hours and were found to be statistically significant compared to the control group. It was determined that broccoli increased apoptosis on breast cancer cells by various mechanisms and inhibited cell viability/cell growth. The results were similar to the results of AgNOR protein synthesis. The study showed that the regular and correct consumption of broccoli could be effective in preventing cancer formation and slowing its progression.","PeriodicalId":10750,"journal":{"name":"Cumhuriyet medical journal","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135579481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Professional health services have been key in the recovery of patients during the COVID-19 pandemic. Health professionals have been in a great effort to meet the care needs of patients despite experiencing a high emotional burden for reasons such as unknown treatment of the disease, high contagiousness, changing working systems, increased workload, and the need to wear protective equipment. The unknown effects of the virus on the health of mothers and babies increased the concerns of midwives helping families in the core of society, which are the most intimate areas, regarding the risk of infection. Midwives had to manage an exhausting process similar to the one experienced by nurses, when they continued providing secondary health services such as immunization, antenatal care, and follow-ups. They are among the health professionals forced to work under highly adverse conditions, such as increased duties and responsibilities in the pandemic, and cancellation of leaves. It is reported that midwives, who are forced to work outside their field of duty due to the pandemic, are highly likely to experience compassion fatigue and to have a low level of life quality as well as professional belonging. Qualitative studies conducted with midwives working in the delivery room reported that midwives in delivery rooms experience compassion fatigue, adopt the concept of compassion fatigue, come up with their own solutions or receive psychological support to deal with compassion fatigue, and that they suggested that psychological support needs be provided by the state. As a result, many mothers and pregnant women lost their lives in this ongoing pandemic process. Alike, many health professionals lost their lives due to the epidemic. Midwives are one of these health professionals. The feeling of helplessness at the beginning of the pandemic, the unknowns about its treatment made the working conditions even more difficult. Considering these, it is reasonable to argue that midwives have been likely to experience compassion fatigue.
{"title":"Does the COVID-19 Pandemic Have an Impact on Compassion Fatigue among Midwives?","authors":"Zeliha YURTSAL, Emine Hilal GÖKSEL","doi":"10.7197/cmj.1302966","DOIUrl":"https://doi.org/10.7197/cmj.1302966","url":null,"abstract":"Professional health services have been key in the recovery of patients during the COVID-19 pandemic. Health professionals have been in a great effort to meet the care needs of patients despite experiencing a high emotional burden for reasons such as unknown treatment of the disease, high contagiousness, changing working systems, increased workload, and the need to wear protective equipment. The unknown effects of the virus on the health of mothers and babies increased the concerns of midwives helping families in the core of society, which are the most intimate areas, regarding the risk of infection. Midwives had to manage an exhausting process similar to the one experienced by nurses, when they continued providing secondary health services such as immunization, antenatal care, and follow-ups. They are among the health professionals forced to work under highly adverse conditions, such as increased duties and responsibilities in the pandemic, and cancellation of leaves. It is reported that midwives, who are forced to work outside their field of duty due to the pandemic, are highly likely to experience compassion fatigue and to have a low level of life quality as well as professional belonging. Qualitative studies conducted with midwives working in the delivery room reported that midwives in delivery rooms experience compassion fatigue, adopt the concept of compassion fatigue, come up with their own solutions or receive psychological support to deal with compassion fatigue, and that they suggested that psychological support needs be provided by the state. As a result, many mothers and pregnant women lost their lives in this ongoing pandemic process. Alike, many health professionals lost their lives due to the epidemic. Midwives are one of these health professionals. The feeling of helplessness at the beginning of the pandemic, the unknowns about its treatment made the working conditions even more difficult. Considering these, it is reasonable to argue that midwives have been likely to experience compassion fatigue.","PeriodicalId":10750,"journal":{"name":"Cumhuriyet medical journal","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135720400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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