Emine Tuğçe Şahin, G. M. Yılmaz Öztekin, A. Genç, Anıl Şahin
Heart failure (HF) is a progressive clinical syndrome associated with significant morbidity and mortality. It is known that during the course of this syndrome, social factors can impact clinical outcomes alongside medical interventions. Studies have demonstrated that social support provides favorable developments in mortality rates, event-free survival, and readmission rates in HF patients. In our study, we aimed to elucidate the effects of the concept of family, the most significant social support, on clinical characteristics, exercise capacity, echocardiographic, and laboratory features in HF cases. A multicenter cohort study was conducted, including 303 patients previously diagnosed with HF, following current guidelines and presenting for outpatient follow-up. Patients with a new diagnosis of HF, those with acute decompensated HF, and those with a history of malignancy were excluded from the study. Demographic data (age, gender), comorbidities (hypertension, diabetes mellitus, atrial fibrillation, etc.), HF treatments, laboratory tests, and detailed transthoracic echocardiography results were recorded. Patients were divided into two groups based on whether they lived with a spouse, parent, child, or without any of them, defining the presence or absence of family support. In the study, 303 patients with an average age of 62.1±13.0, of which 94 (31%) were female, were included. The mean left ventricular ejection fraction was 28.7±8.1. When the groups were compared in terms of comorbidities, there was no statistically significant difference in the presence of hypertension, diabetes mellitus, hyperlipidemia, chronic obstructive pulmonary disease, stroke, or atrial fibrillation (all p>0.005). Coronary artery disease was more frequently observed in the group with family support, while chronic kidney disease was more common in the group without family support (p=0.008 and p=0.012, respectively). Smoking prevalence was significantly higher in the group without family support, while alcohol use showed no significant difference (p=0.046 and p=0.602, respectively). Analyzing the results, it was observed that patients with family support were more regularly monitored for HF reasons (71% vs. 59%, p=0.054). It has been observed that the social support provided by family members in individuals with HF can have positive effects on the clinical course of the disease and the patient's lifestyle.
{"title":"The Relationship Between Living with Family and Clinical, Demographic, and Laboratory Characteristics in Patients with Heart Failure","authors":"Emine Tuğçe Şahin, G. M. Yılmaz Öztekin, A. Genç, Anıl Şahin","doi":"10.7197/cmj.1414749","DOIUrl":"https://doi.org/10.7197/cmj.1414749","url":null,"abstract":"Heart failure (HF) is a progressive clinical syndrome associated with significant morbidity and mortality. It is known that during the course of this syndrome, social factors can impact clinical outcomes alongside medical interventions. Studies have demonstrated that social support provides favorable developments in mortality rates, event-free survival, and readmission rates in HF patients. In our study, we aimed to elucidate the effects of the concept of family, the most significant social support, on clinical characteristics, exercise capacity, echocardiographic, and laboratory features in HF cases. \u0000A multicenter cohort study was conducted, including 303 patients previously diagnosed with HF, following current guidelines and presenting for outpatient follow-up. Patients with a new diagnosis of HF, those with acute decompensated HF, and those with a history of malignancy were excluded from the study. Demographic data (age, gender), comorbidities (hypertension, diabetes mellitus, atrial fibrillation, etc.), HF treatments, laboratory tests, and detailed transthoracic echocardiography results were recorded. \u0000Patients were divided into two groups based on whether they lived with a spouse, parent, child, or without any of them, defining the presence or absence of family support. In the study, 303 patients with an average age of 62.1±13.0, of which 94 (31%) were female, were included. The mean left ventricular ejection fraction was 28.7±8.1. When the groups were compared in terms of comorbidities, there was no statistically significant difference in the presence of hypertension, diabetes mellitus, hyperlipidemia, chronic obstructive pulmonary disease, stroke, or atrial fibrillation (all p>0.005). Coronary artery disease was more frequently observed in the group with family support, while chronic kidney disease was more common in the group without family support (p=0.008 and p=0.012, respectively). Smoking prevalence was significantly higher in the group without family support, while alcohol use showed no significant difference (p=0.046 and p=0.602, respectively). Analyzing the results, it was observed that patients with family support were more regularly monitored for HF reasons (71% vs. 59%, p=0.054). \u0000It has been observed that the social support provided by family members in individuals with HF can have positive effects on the clinical course of the disease and the patient's lifestyle.","PeriodicalId":10750,"journal":{"name":"Cumhuriyet medical journal","volume":"4 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140397921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aim: A significant portion of admissions to emergency departments are made up of elderly patients. We aim to determine the causes of acute abdomen in geriatric patients requiring emergency surgery, evaluate postoperative intensive care needs and mortality rates, and raise awareness about this patient group. Method: Patient files of individuals aged 65 and older who were consulted in our hospital's emergency department and subsequently admitted to the general surgery service between 2021 and 2023 were retrospectively reviewed. Data including age, gender, underlying diseases, additional illnesses, duration of stay in the intensive care unit, cause of mortality, and length of hospital stay were extracted from the patient's records. The collected data were analyzed statistically for comparisons. Results: Data of 27 patients were accessed.these patients, 40.7% (n=11) were female, and 59.3% (n=16) were male. The average age of the patients was determined to be 74.81 years (ranging from 65 to 88). Thirteen patients, comprising 5 males and 8 females, were monitored in the intensive care unit. 6 patients experienced mortality, and all of them were those admitted to the intensive care unit. When comparing mortality rates based on gender, it was 18.8% in male patients and 27.3% in female patients. All 27 patients had at least one comorbidity . Patients who experienced mortality had at least two comorbidities. Twelve patients did not undergo surgery. Conclisions: In the emergency assessment of geriatric patients, a prompt diagnosis should be made, considering comorbidities after diagnosis, and follow-up and treatments should be adjusted multidisciplinary for patients requiring intensive care or those to be monitored in regular rooms.
{"title":"Our experience with emergency surgery in geriatric patients.","authors":"S. Soylu","doi":"10.7197/cmj.1431097","DOIUrl":"https://doi.org/10.7197/cmj.1431097","url":null,"abstract":"Aim: A significant portion of admissions to emergency departments are made up of elderly patients. We aim to determine the causes of acute abdomen in geriatric patients requiring emergency surgery, evaluate postoperative intensive care needs and mortality rates, and raise awareness about this patient group. \u0000Method: Patient files of individuals aged 65 and older who were consulted in our hospital's emergency department and subsequently admitted to the general surgery service between 2021 and 2023 were retrospectively reviewed. Data including age, gender, underlying diseases, additional illnesses, duration of stay in the intensive care unit, cause of mortality, and length of hospital stay were extracted from the patient's records. The collected data were analyzed statistically for comparisons. \u0000Results: Data of 27 patients were accessed.these patients, 40.7% (n=11) were female, and 59.3% (n=16) were male. The average age of the patients was determined to be 74.81 years (ranging from 65 to 88). Thirteen patients, comprising 5 males and 8 females, were monitored in the intensive care unit. 6 patients experienced mortality, and all of them were those admitted to the intensive care unit. When comparing mortality rates based on gender, it was 18.8% in male patients and 27.3% in female patients. All 27 patients had at least one comorbidity . Patients who experienced mortality had at least two comorbidities. Twelve patients did not undergo surgery. \u0000Conclisions: In the emergency assessment of geriatric patients, a prompt diagnosis should be made, considering comorbidities after diagnosis, and follow-up and treatments should be adjusted multidisciplinary for patients requiring intensive care or those to be monitored in regular rooms.","PeriodicalId":10750,"journal":{"name":"Cumhuriyet medical journal","volume":"59 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140398706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chiari malformations (CM) refer to a series of anomalies characterized by the descent of cerebellar tonsils into the cervical spinal canal. These malformations can be associated with abnormalities such as syringomyelia, hydrocephalus, spina bifida, and scoliosis. Additionally, craniocervical junction anomalies, endocrinopathies, craniosynostosis, and syndromic disorders are also linked to CM. The treatment of CM is surgical, and there is no known medical therapy. Patients diagnosed with CM are typically advised to undergo surgical treatment or follow-up. Although surgical intervention is supported in the literature, debates exist regarding which procedure is most suitable and when surgery should be performed. In this article, we will examine the historical background of CM, its anatomical forms, pathophysiology, clinical presentation, relationship with other diseases, and diagnostic procedures in the light of the literature.
奇拉氏畸形（Chiari malformations，CM）是指小脑扁桃体下降到颈椎管内的一系列畸形。这些畸形可能与鞘膜积液、脑积水、脊柱裂和脊柱侧弯等畸形有关。此外，颅颈交界处异常、内分泌病、颅骨发育不良和综合症也与 CM 有关。CM 的治疗方法是手术，目前还没有已知的药物疗法。确诊为 CM 的患者通常会被建议接受手术治疗或随访。虽然文献支持手术干预，但对于哪种手术最合适以及何时进行手术仍存在争议。在本文中，我们将根据文献研究 CM 的历史背景、解剖形式、病理生理学、临床表现、与其他疾病的关系以及诊断程序。
{"title":"Arnold Chiari Malformation","authors":"Zekeriya Bulut","doi":"10.7197/cmj.1411030","DOIUrl":"https://doi.org/10.7197/cmj.1411030","url":null,"abstract":"Chiari malformations (CM) refer to a series of anomalies characterized by the descent of cerebellar tonsils into the cervical spinal canal. These malformations can be associated with abnormalities such as syringomyelia, hydrocephalus, spina bifida, and scoliosis. Additionally, craniocervical junction anomalies, endocrinopathies, craniosynostosis, and syndromic disorders are also linked to CM. The treatment of CM is surgical, and there is no known medical therapy. Patients diagnosed with CM are typically advised to undergo surgical treatment or follow-up. Although surgical intervention is supported in the literature, debates exist regarding which procedure is most suitable and when surgery should be performed. In this article, we will examine the historical background of CM, its anatomical forms, pathophysiology, clinical presentation, relationship with other diseases, and diagnostic procedures in the light of the literature.","PeriodicalId":10750,"journal":{"name":"Cumhuriyet medical journal","volume":"16 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140433031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Inflammation which is a response of immune system was demonstrated in many disorders such as atherosclerosis, hypertension, diabetes, cancer and rheumatoid arthritis. Metformin, an oral antidiabetic drug, has anti-inflammatory effect apart from blood glucose regulatory effect. However, the mechanism of its anti-inflammatory effect is not clearly understood. In this study, the effect of metformin on the release of cytokines (TNF-α and IL-6) from LPS stimulated rat mononuclear blood cells was investigated. Blood samples (5ml) were taken from healthy, male, 8-12 weeks old rats (n=5, 200-250g) through cardiac puncture under general anesthesia into sterile EDTA containing tubes. Monocytes were separated by centrifugation and were resuspended in RPMI 1640 media (3.3±0.2x105 /ml). Cells were then incubated with metformin (2.5 µM, 25 µM, 250 µM) for 2,5 hours followed by addition of LPS (100 ng/ml, 1µg/ml) for further 5 hours. After centrifugation, the supernatant was taken and TNF-α level was measured by ELISA. There was no statistically significant change in the amounts of TNF-α in the LPS + metformin groups compared to the 100 ng/ml LPS group (p>0.05). In LPS+metformin groups, compared to 1 µg/ml LPS, 2.5 µM and 250 µM metformin significantly increased TNF-α levels (p0.05). The amount of IL-6 was not within measurable range in this study. In summary, metformin increased the amount of released TNF-α rather than decreased in our study.
{"title":"EFFECTS OF METFORMIN ON TNF-α RELEASE IN LIPOPOLYSACCHARIDE-INDUCED MONOCYTES IN RATS","authors":"Emre Gedikli, Mesut Parlak, A. Soydan","doi":"10.7197/cmj.1413260","DOIUrl":"https://doi.org/10.7197/cmj.1413260","url":null,"abstract":"Inflammation which is a response of immune system was demonstrated in many disorders such as atherosclerosis, hypertension, diabetes, cancer and rheumatoid arthritis. Metformin, an oral antidiabetic drug, has anti-inflammatory effect apart from blood glucose regulatory effect. However, the mechanism of its anti-inflammatory effect is not clearly understood. In this study, the effect of metformin on the release of cytokines (TNF-α and IL-6) from LPS stimulated rat mononuclear blood cells was investigated. Blood samples (5ml) were taken from healthy, male, 8-12 weeks old rats (n=5, 200-250g) through cardiac puncture under general anesthesia into sterile EDTA containing tubes. Monocytes were separated by centrifugation and were resuspended in RPMI 1640 media (3.3±0.2x105 /ml). Cells were then incubated with metformin (2.5 µM, 25 µM, 250 µM) for 2,5 hours followed by addition of LPS (100 ng/ml, 1µg/ml) for further 5 hours. After centrifugation, the supernatant was taken and TNF-α level was measured by ELISA. There was no statistically significant change in the amounts of TNF-α in the LPS + metformin groups compared to the 100 ng/ml LPS group (p>0.05). In LPS+metformin groups, compared to 1 µg/ml LPS, 2.5 µM and 250 µM metformin significantly increased TNF-α levels (p0.05). The amount of IL-6 was not within measurable range in this study. In summary, metformin increased the amount of released TNF-α rather than decreased in our study.","PeriodicalId":10750,"journal":{"name":"Cumhuriyet medical journal","volume":"2 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140499613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Salivary gland ductal carcinoma (SDC) is a rare, aggressive tumor with a highly malignant course and originates most frequently from the parotid gland among the major salivary glands. The incidence of accessory parotid gland (APG) varies between 21-56% and the incidence of tumor in APG is 1-8% of all parotid tumors. SDC is rarely seen in accessory glands. It was aimed to present our case, which was diagnosed with SDC in APG, in the light of the literature.
{"title":"Salivary Gland Ductal Carcinoma of Accessory Parotid Gland","authors":"Adem Bora, Esra Nur Göksu, Tulay Koc","doi":"10.7197/cmj.1210808","DOIUrl":"https://doi.org/10.7197/cmj.1210808","url":null,"abstract":"Salivary gland ductal carcinoma (SDC) is a rare, aggressive tumor with a highly malignant course and originates most frequently from the parotid gland among the major salivary glands. The incidence of accessory parotid gland (APG) varies between 21-56% and the incidence of tumor in APG is 1-8% of all parotid tumors. SDC is rarely seen in accessory glands. It was aimed to present our case, which was diagnosed with SDC in APG, in the light of the literature.","PeriodicalId":10750,"journal":{"name":"Cumhuriyet medical journal","volume":"87 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139151716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Endoscopic Transcanal Stapes Surgery: Our Audiological and Surgical Results Adem Bora, Tuğberk Salık Sivas Republic University Health Services Application and Research Hospital, Ear Nose Throat Clinic, Sivas, Turkey ABSTRACT Aim: The aim of this study is to investigate the intraoperative and postoperative results of endoscopic stapes surgery performed at our institution. Methods: A total of 25 patients with 28 ears (14 right, 14 left ears) who underwent endoscopic stapes surgery between 2018 and 2022 were analyzed for postoperative hearing outcomes and surgical complications at the 6-month follow-up. Results: The average age of the patients was 43.16 years (range, 24-63 years), and 64.0% of the patients were female. The median preoperative air-bone gap decreased from 30.36 dB hearing level (HL) to 18.95 dB HL after surgery (P < 0.001). The postoperative air-bone gap was 10 dB or lower in 8 patients (28.6%), 11-20 dB in 10 patients (35.7%), and more than 20 dB in 6 patients (21.4%). Intraoperative complications included only tympanic membrane ruptures in one patient, which resolved during the initial follow-up. Postoperatively, 10.7% of the subjects complained of changes in taste sensation. One patient developed facial paralysis responsive to steroid treatment one week after surgery. Conclusion: Endoscopic surgery is particularly suitable for stapedial disorders. Endoscopic stapes surgery is minimally invasive and suitable for surgical training, as surgical anatomy can be easily understood, and both the surgeon and assistant can observe the procedure from the same monitor. The operation should only be performed by experienced surgeons due to the need for single-handed operation and the lack of stereoscopic vision. Keywords: Stapes; Stapedectomy; Outcomes; Endoscopic ear surgery
内窥镜经鼻镫骨手术：Adem Bora, Tuğberk Salık Sivas Republic University Health Services Application and Research Hospital, Ear Nose Throat Clinic, Sivas, Turkey ABSTRACT Aim: The aim of this study is to investigate the intraoperative and postoperations results of endoscopic stapes surgery performed at our institution. 手术方法对2018年至2022年期间接受内窥镜镫骨手术的共25名患者的28只耳朵（右耳14只，左耳14只）的术后听力结果和6个月随访时的手术并发症进行分析。 结果：患者平均年龄为 43.16 岁（24-63 岁），64.0% 的患者为女性。术前气骨间隙的中位数从听力水平（HL）的 30.36 dB 降至术后的 18.95 dB HL（P < 0.001）。术后气骨间隙在 10 dB 或以下的患者有 8 名（28.6%），11-20 dB 的患者有 10 名（35.7%），超过 20 dB 的患者有 6 名（21.4%）。术中并发症仅包括一名患者的鼓膜破裂，该并发症在最初的随访中得到缓解。术后，10.7% 的受试者抱怨味觉发生了变化。一名患者在术后一周出现面瘫，对类固醇治疗有反应。 结论内窥镜手术尤其适用于镫骨疾病。内窥镜镫骨手术是一种微创手术，适合外科培训，因为手术解剖学很容易理解，外科医生和助手可以从同一个监视器上观察手术过程。由于需要单手操作且缺乏立体视觉，该手术只能由经验丰富的外科医生进行。 关键词镫骨; 镫骨切除术; 效果; 耳内窥镜手术
{"title":"Endoscopic Transcanal Stapes Surgery: Our Audiological and Surgical Results","authors":"Adem Bora, Kazım Tuğberk Salik","doi":"10.7197/cmj.1374207","DOIUrl":"https://doi.org/10.7197/cmj.1374207","url":null,"abstract":"Endoscopic Transcanal Stapes Surgery: Our Audiological and Surgical Results Adem Bora, Tuğberk Salık Sivas Republic University Health Services Application and Research Hospital, Ear Nose Throat Clinic, Sivas, Turkey ABSTRACT Aim: The aim of this study is to investigate the intraoperative and postoperative results of endoscopic stapes surgery performed at our institution. Methods: A total of 25 patients with 28 ears (14 right, 14 left ears) who underwent endoscopic stapes surgery between 2018 and 2022 were analyzed for postoperative hearing outcomes and surgical complications at the 6-month follow-up. Results: The average age of the patients was 43.16 years (range, 24-63 years), and 64.0% of the patients were female. The median preoperative air-bone gap decreased from 30.36 dB hearing level (HL) to 18.95 dB HL after surgery (P < 0.001). The postoperative air-bone gap was 10 dB or lower in 8 patients (28.6%), 11-20 dB in 10 patients (35.7%), and more than 20 dB in 6 patients (21.4%). Intraoperative complications included only tympanic membrane ruptures in one patient, which resolved during the initial follow-up. Postoperatively, 10.7% of the subjects complained of changes in taste sensation. One patient developed facial paralysis responsive to steroid treatment one week after surgery. Conclusion: Endoscopic surgery is particularly suitable for stapedial disorders. Endoscopic stapes surgery is minimally invasive and suitable for surgical training, as surgical anatomy can be easily understood, and both the surgeon and assistant can observe the procedure from the same monitor. The operation should only be performed by experienced surgeons due to the need for single-handed operation and the lack of stereoscopic vision. Keywords: Stapes; Stapedectomy; Outcomes; Endoscopic ear surgery","PeriodicalId":10750,"journal":{"name":"Cumhuriyet medical journal","volume":"32 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139151535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aim: Nesfatin-1 is a recently discovered adipocytokine that is believed to regulate food intake and is linked to body mass index. While its precise mechanism of action remains unclear, a deeper understanding of how nesfatin-1 interacts with metabolic diseases, inflammation, and insulin resistance could have significant implications for the treatment of a wide range of conditions, including cardiovascular disease. Smoking is a complex issue with roots in social, cultural, and economic factors that can contribute to nicotine addiction. Additionally, nicotine's ability to stimulate the mind and promote feelings of relaxation can create a positive feedback loop that makes it difficult to quit. Unfortunately, there is limited research on the effects of smoking on Nesfatin-1 levels. However, one study found that women who smoke tend to have lower levels of Nesfatin-1. To build on this finding, the present study aims to further investigate nesfatin-1 levels in both smokers and non-smokers. Methods: A total of 70 participants, smokers (n=35) and non-smokers (n=35), were included in the study. The participant's gender, age, height and weight, body mass index, and nesfatin-1 levels were measured and compared. The SPSS 23.0 program was used to evaluate the data statistically. Data were evaluated with a t-test. The error level was taken as 0.05. Result: Serum Nesfatin-1 levels were significantly higher in smokers (13.73± 3.11) than in non-smokers (8.63 ± 0.91) (t=-9.315, p<0.01). No significant difference was found between other parameters in the smoker and non-smoker groups. Conclusion: Our study has shown that individuals who smoke display higher levels of Nesfatin-1 compared to non-smokers, indicating a correlation between smoking and Nesfatin-1. However, further investigation is required to understand the mechanism behind this increase. It is hoped that continued research will unveil the potential of Nesfatin-1 in treating human obesity.
{"title":"EVALUATION OF THE EFFECT OF SMOKING ON NESFATIN-1 LEVEL","authors":"Burak Oğulcan Yildirim","doi":"10.7197/cmj.1410528","DOIUrl":"https://doi.org/10.7197/cmj.1410528","url":null,"abstract":"Aim: Nesfatin-1 is a recently discovered adipocytokine that is believed to regulate food intake and is linked to body mass index. While its precise mechanism of action remains unclear, a deeper understanding of how nesfatin-1 interacts with metabolic diseases, inflammation, and insulin resistance could have significant implications for the treatment of a wide range of conditions, including cardiovascular disease. Smoking is a complex issue with roots in social, cultural, and economic factors that can contribute to nicotine addiction. Additionally, nicotine's ability to stimulate the mind and promote feelings of relaxation can create a positive feedback loop that makes it difficult to quit. Unfortunately, there is limited research on the effects of smoking on Nesfatin-1 levels. However, one study found that women who smoke tend to have lower levels of Nesfatin-1. To build on this finding, the present study aims to further investigate nesfatin-1 levels in both smokers and non-smokers. Methods: A total of 70 participants, smokers (n=35) and non-smokers (n=35), were included in the study. The participant's gender, age, height and weight, body mass index, and nesfatin-1 levels were measured and compared. The SPSS 23.0 program was used to evaluate the data statistically. Data were evaluated with a t-test. The error level was taken as 0.05. Result: Serum Nesfatin-1 levels were significantly higher in smokers (13.73± 3.11) than in non-smokers (8.63 ± 0.91) (t=-9.315, p<0.01). No significant difference was found between other parameters in the smoker and non-smoker groups. Conclusion: Our study has shown that individuals who smoke display higher levels of Nesfatin-1 compared to non-smokers, indicating a correlation between smoking and Nesfatin-1. However, further investigation is required to understand the mechanism behind this increase. It is hoped that continued research will unveil the potential of Nesfatin-1 in treating human obesity.","PeriodicalId":10750,"journal":{"name":"Cumhuriyet medical journal","volume":"289 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139152693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Work accidents are of great concern to society because they directly affect the health and life of workers and the production process of the enterprise, as well as creating significant social and economic costs for workers, employers, the country's economy and society. In this study, the total of 1.048 occupational injury cases who applied to Emergency Department of Cumhuriyet University Faculty of Medicine between 2011-2015 was evaluated. In this study; frequency, chi-square and percentage tests were used in the analysis of data. 1.034 (98.7%) of the cases was male and the rest was female. The cases were more often between the ages of 25-34 (36.2%). 64.2% of applications to emergency were occured between 08:01-17:00. The accidents were more often at metal/machine industry (20.8%). It was seen that it was not mentioned whether the injuries could be resolved with simple medical intervention in 84.4% of the reports. There wasn’t an alcohol evaluation at most (92%) of the cases. Most of the injuries were located at upper extremity (39.6%). The most observed lesion was soft tissue damage (35.3%). 624 of the cases (59.6%) were discharged after treatment in emergency department. It was determined that the number of cases applied to the Department of Forensic Medicine by the prosecutor's office or court decision after occupational accident was 29 (2.8%); in 79.3% of cases, the injuries could be resolved with simple medical intervention; in 24.1%, there was life-threatening; in 3.4%, there was declining function; in 6.9%, there was loss of function. Inadequacies in the writing of forensic reports will cause serious legal problems. In addition, it was concluded that it is important to raise awareness for all healthcare personnel, especially emergency physicians, and to provide up-to-date training for forensic case reporting and proper-complete preparation of forensic reports.
{"title":"THE MEDICOLEGAL EVALUATION OF OCCUPATIONAL INJURY CASES APPLIED TO EMERGENCY DEPARTMENT OF CUMHURIYET UNIVERSITY HOSPITAL","authors":"Adem Artar, Celal Butun, Fatma YÜCEL BEYAZTAŞ","doi":"10.7197/cmj.1377887","DOIUrl":"https://doi.org/10.7197/cmj.1377887","url":null,"abstract":"Work accidents are of great concern to society because they directly affect the health and life of workers and the production process of the enterprise, as well as creating significant social and economic costs for workers, employers, the country's economy and society. In this study, the total of 1.048 occupational injury cases who applied to Emergency Department of Cumhuriyet University Faculty of Medicine between 2011-2015 was evaluated. In this study; frequency, chi-square and percentage tests were used in the analysis of data. 1.034 (98.7%) of the cases was male and the rest was female. The cases were more often between the ages of 25-34 (36.2%). 64.2% of applications to emergency were occured between 08:01-17:00. The accidents were more often at metal/machine industry (20.8%). It was seen that it was not mentioned whether the injuries could be resolved with simple medical intervention in 84.4% of the reports. There wasn’t an alcohol evaluation at most (92%) of the cases. Most of the injuries were located at upper extremity (39.6%). The most observed lesion was soft tissue damage (35.3%). 624 of the cases (59.6%) were discharged after treatment in emergency department. It was determined that the number of cases applied to the Department of Forensic Medicine by the prosecutor's office or court decision after occupational accident was 29 (2.8%); in 79.3% of cases, the injuries could be resolved with simple medical intervention; in 24.1%, there was life-threatening; in 3.4%, there was declining function; in 6.9%, there was loss of function. Inadequacies in the writing of forensic reports will cause serious legal problems. In addition, it was concluded that it is important to raise awareness for all healthcare personnel, especially emergency physicians, and to provide up-to-date training for forensic case reporting and proper-complete preparation of forensic reports.","PeriodicalId":10750,"journal":{"name":"Cumhuriyet medical journal","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139153834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aim: This study aims to present the results of a single surgeon's experience to demonstrate the effectiveness of the 'Critical View of Safety' (CVS) technique in preventing bile duct injuries in clinical practice. Method: We retrospectively reviewed the records of 899 patients who underwent cholecystectomy using the CVS technique performed by a single surgeon at the Sivas Cumhuriyet University Hospital General Surgery Department between 2018 and 2023. Ethical approval for the study was obtained. Cholecystectomy cases were scanned retrospectively. The patients' age, gender, drain placement, surgery indications, and reason for switching to open cholecystectomy were recorded. Results: Among the 899 patients reviewed, 312 were male (34.70%), and 587 were female (65.30%). The average age was 55.10 for males and 51,65 for females. It was determined that 7(0.77%), cases converted to open cholecystectomy. The most common indication for cholecystectomy was elective gallbladder stone removal, accounting for 47.05% of cases. No major bile duct injuries were detected.. Conclusions: The safe cholecystectomy technique can be safely applied to avoid bile duct injuries in laparoscopic cholecystectomy.
{"title":"Is the Safe Cholecystectomy Technique Really Safe?","authors":"S. Soylu","doi":"10.7197/cmj.1404025","DOIUrl":"https://doi.org/10.7197/cmj.1404025","url":null,"abstract":"Aim: This study aims to present the results of a single surgeon's experience to demonstrate the effectiveness of the 'Critical View of Safety' (CVS) technique in preventing bile duct injuries in clinical practice. Method: We retrospectively reviewed the records of 899 patients who underwent cholecystectomy using the CVS technique performed by a single surgeon at the Sivas Cumhuriyet University Hospital General Surgery Department between 2018 and 2023. Ethical approval for the study was obtained. Cholecystectomy cases were scanned retrospectively. The patients' age, gender, drain placement, surgery indications, and reason for switching to open cholecystectomy were recorded. Results: Among the 899 patients reviewed, 312 were male (34.70%), and 587 were female (65.30%). The average age was 55.10 for males and 51,65 for females. It was determined that 7(0.77%), cases converted to open cholecystectomy. The most common indication for cholecystectomy was elective gallbladder stone removal, accounting for 47.05% of cases. No major bile duct injuries were detected.. Conclusions: The safe cholecystectomy technique can be safely applied to avoid bile duct injuries in laparoscopic cholecystectomy.","PeriodicalId":10750,"journal":{"name":"Cumhuriyet medical journal","volume":"173 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139153737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The issue of elder abuse and neglect is an important public health problem that requires urgent attention from social assistance institutions, health systems, political institutions and citizens, can create devastating individual and social consequences, and is not unfortunately adequately reported. Elder abuse can cause serious consequences on both mental and physical health, such as injury, death, anxiety, depression, substance addiction, and suicide. Necessary precautions should be taken to prevent elder abuse. First of all, it is very important to raise awareness of elder abuse and to raise awareness of the entire society on this issue.
{"title":"FORENSIC MEDICAL PERSPECTIVE OF ELDER ABUSE","authors":"Fatma YÜCEL BEYAZTAŞ, Celal Butun, Gökhan Kurt","doi":"10.7197/cmj.1377781","DOIUrl":"https://doi.org/10.7197/cmj.1377781","url":null,"abstract":"The issue of elder abuse and neglect is an important public health problem that requires urgent attention from social assistance institutions, health systems, political institutions and citizens, can create devastating individual and social consequences, and is not unfortunately adequately reported. Elder abuse can cause serious consequences on both mental and physical health, such as injury, death, anxiety, depression, substance addiction, and suicide. Necessary precautions should be taken to prevent elder abuse. First of all, it is very important to raise awareness of elder abuse and to raise awareness of the entire society on this issue.","PeriodicalId":10750,"journal":{"name":"Cumhuriyet medical journal","volume":"141 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139153967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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