Absract: The latest research have demonstrated that inflammation, oxidative stress and apoptosis plays a majör role in morphine analgesia and tolerance development. This search goals to examine the possible role of thiamine use on oxidative stress, inflammation and apoptosis in the development of morphine analgesia and morphine tolerance in rats. Methods: Thirty-six male Wistar rats were used in this study. The rats were severed into six groups: saline, 100 mg/kg thiamine, 5 mg/kg morphine, thiamine + morphine, morphine tolerance and thiamine + morphine tolerance. The resulting analgesic effect was measured by hot plate and tail movement analgesia tests. TAS and TOS, inflammation parameters, and apoptosis protein levels of the dorsal root ganglion tissues sample were measured using an ELISA kit. Results: When thiamine was given alone, it did not show anti-nociceptive effect (p>0.05). In addition, thiamine enhanced the analgesic effect of morphine (p < 0.05) and also significantly reduced tolerance to morphine (p < 0.05). However, it reduced TOS when administered with a single dose of morphine and tolerance induction (p < 0.05). In addition, thiamine reduced apoptosis protein levels after tolerance development (p < 0.05). Conclusion: Consequently, these results may attain by reducing TOS, inflammation, and apoptosis.
{"title":"EFFECT OF THİAMİNE ON MORPHİNE ANALGESİA AND TOLERANCE İN RATS","authors":"Arzuhan ÇETİNDAĞ ÇİLTAŞ, Ayşegül Öztürk","doi":"10.7197/cmj.1153681","DOIUrl":"https://doi.org/10.7197/cmj.1153681","url":null,"abstract":"Absract: The latest research have demonstrated that inflammation, oxidative stress and apoptosis plays a majör role in morphine analgesia and tolerance development. This search goals to examine the possible role of thiamine use on oxidative stress, inflammation and apoptosis in the development of morphine analgesia and morphine tolerance in rats. \u0000Methods: Thirty-six male Wistar rats were used in this study. The rats were severed into six groups: saline, 100 mg/kg thiamine, 5 mg/kg morphine, thiamine + morphine, morphine tolerance and thiamine + morphine tolerance. The resulting analgesic effect was measured by hot plate and tail movement analgesia tests. TAS and TOS, inflammation parameters, and apoptosis protein levels of the dorsal root ganglion tissues sample were measured using an ELISA kit. \u0000Results: When thiamine was given alone, it did not show anti-nociceptive effect (p>0.05). In addition, thiamine enhanced the analgesic effect of morphine (p < 0.05) and also significantly reduced tolerance to morphine (p < 0.05). However, it reduced TOS when administered with a single dose of morphine and tolerance induction (p < 0.05). In addition, thiamine reduced apoptosis protein levels after tolerance development (p < 0.05). \u0000Conclusion: Consequently, these results may attain by reducing TOS, inflammation, and apoptosis.","PeriodicalId":10750,"journal":{"name":"Cumhuriyet medical journal","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85294908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
As a result of the spread of the COVID-19 virus all over the world, starting from China in 2019, curiosity about the course of the epidemics that took place in history has increased. Many epidemics have occurred in history, and many different precautions have been taken against these diseases. Islam is a religion based on hygiene and cleanliness, both physically and spiritually. In the history of Islam, Hz. Prophet has many advice about the precautions to be taken against epidemics. In addition to epidemics in the world, another factor that affects people both physiologically and psychologically and is released in a controlled manner is the microorganisms used as biological weapons. These weapons cause more chaos and terror than epidemics. Moreover, even small amounts are enough to destroy millions of people. COVID-19 is the last pandemic in the world, and its effects are still ongoing. Although some people claim that this virus is a biological weapon programmed in the laboratory, genetic sequencing has proven it to be a natural virus.
{"title":"Epidemic Diseases, Biological Weapons, and the Relationship of Religion with COVID-19","authors":"A. Alim, Rukiye Aslan","doi":"10.7197/cmj.1258743","DOIUrl":"https://doi.org/10.7197/cmj.1258743","url":null,"abstract":"As a result of the spread of the COVID-19 virus all over the world, starting from China in 2019, curiosity about the course of the epidemics that took place in history has increased. Many epidemics have occurred in history, and many different precautions have been taken against these diseases. Islam is a religion based on hygiene and cleanliness, both physically and spiritually. In the history of Islam, Hz. Prophet has many advice about the precautions to be taken against epidemics. In addition to epidemics in the world, another factor that affects people both physiologically and psychologically and is released in a controlled manner is the microorganisms used as biological weapons. These weapons cause more chaos and terror than epidemics. Moreover, even small amounts are enough to destroy millions of people. COVID-19 is the last pandemic in the world, and its effects are still ongoing. Although some people claim that this virus is a biological weapon programmed in the laboratory, genetic sequencing has proven it to be a natural virus.","PeriodicalId":10750,"journal":{"name":"Cumhuriyet medical journal","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90489545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The COVID-19 pandemic is a rapidly spreading virus outbreak affecting the lives of people globally in terms of health, economy, social and psychological aspects. Governments have taken various measures to protect the functioning of societal life and individual health. To prevent the spread of the virus in society, measures such as lockdown, travel restrictions, ban on gatherings in enclosed spaces, closure of certain businesses, school closures and transition to remote learning were taken. In addition, on an individual level, measures such as wearing masks, practicing personal hygiene and maintaining physical distance were taken. The uncertainty of the situation has weakened people's sense of security. Health concerns, job losses, social isolation, financial turmoil and low morale have increased people's worries about the future. The long-term effects of the pandemic are still not fully understood, but it is known that the sense of security plays a significant role in both the quality and level of life of society and individuals. The sense of security of individuals is important in every aspect of life and the loss of this feeling can negatively impact their economic, physical, emotional, and social health. This study, conducted using a literature review method, aimed to identify the psycho-social and economic problems arising during the pandemic process. The results of the study indicated that the pandemic experienced globally caused serious problems for both individuals and society and that these problems are likely to have impacts in the "new normal" life after the pandemic.
{"title":"INDIVIDUAL IMPACT OF COVID-19 PANDEMIC IN A STATE OF UNCERTAINTY ON TRUST BASIS","authors":"Osman Alacahan","doi":"10.7197/cmj.1248760","DOIUrl":"https://doi.org/10.7197/cmj.1248760","url":null,"abstract":"The COVID-19 pandemic is a rapidly spreading virus outbreak affecting the lives of people globally in terms of health, economy, social and psychological aspects. Governments have taken various measures to protect the functioning of societal life and individual health. To prevent the spread of the virus in society, measures such as lockdown, travel restrictions, ban on gatherings in enclosed spaces, closure of certain businesses, school closures and transition to remote learning were taken. In addition, on an individual level, measures such as wearing masks, practicing personal hygiene and maintaining physical distance were taken. The uncertainty of the situation has weakened people's sense of security. Health concerns, job losses, social isolation, financial turmoil and low morale have increased people's worries about the future. The long-term effects of the pandemic are still not fully understood, but it is known that the sense of security plays a significant role in both the quality and level of life of society and individuals. The sense of security of individuals is important in every aspect of life and the loss of this feeling can negatively impact their economic, physical, emotional, and social health. This study, conducted using a literature review method, aimed to identify the psycho-social and economic problems arising during the pandemic process. The results of the study indicated that the pandemic experienced globally caused serious problems for both individuals and society and that these problems are likely to have impacts in the \"new normal\" life after the pandemic.","PeriodicalId":10750,"journal":{"name":"Cumhuriyet medical journal","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80939941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aim: Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and was declared a pandemic by the World Health Organization (WHO) on March 11, 2020. We aimed to investigate the frequency of head and spinal injuries caused by trauma before and after the pandemic. To identify the situations that should be taken into account in isolation measures due to the possibility of the emergence of such epidemics in the globalizing world. Material and Method: Medical records of 2595 patients were accessed and 1309 patients with missing patient data were excluded from the study. Normal distribution of continuous variables was assessed using Kolmogorov-Smirnov test. Continuous variables were compared using Mann-Whitney U test and categorical variables were compared using Chi-square test or Fisher’s exact test. Results: Data of 1286 patients were analyzed. Some parameters differ before and after the pandemic, age, injury mechanism, type of lesion, spinal trauma. The average age is 33.9 and the male-female ratio is 3/2. The most frequent admission to the emergency room was in the summer. In our data, there were significant differences in age, gunshot wounds in the trauma mechanism, soft tissue injury and contusion in lesions, and spinal trauma. Conclusion: The Covid pandemic has caused imperative changes in every aspect of life. This situation also caused a change in the reasons for applying to hospitals. It has been shown that the isolations performed because of Covid-19 did not affect the diagnosis, treatment, and mortality of the patients, although they changed the mechanisms of head and spine trauma. Even with compulsory isolation for public health, the approach to neurosurgical traumas that may occur should not change. It should not be forgotten that in the presence of the Covid 19 pandemic, it continues in other clinical situations.
{"title":"Effects of COVID-19 Isolation Practices on Neurosurgical Traumas","authors":"R. S. Aktaş, Eyüp Çetin","doi":"10.7197/cmj.1148308","DOIUrl":"https://doi.org/10.7197/cmj.1148308","url":null,"abstract":"Aim: Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and was declared a pandemic by the World Health Organization (WHO) on March 11, 2020. We aimed to investigate the frequency of head and spinal injuries caused by trauma before and after the pandemic. To identify the situations that should be taken into account in isolation measures due to the possibility of the emergence of such epidemics in the globalizing world. \u0000Material and Method: Medical records of 2595 patients were accessed and 1309 patients with missing patient data were excluded from the study. Normal distribution of continuous variables was assessed using Kolmogorov-Smirnov test. Continuous variables were compared using Mann-Whitney U test and categorical variables were compared using Chi-square test or Fisher’s exact test. \u0000Results: Data of 1286 patients were analyzed. Some parameters differ before and after the pandemic, age, injury mechanism, type of lesion, spinal trauma. The average age is 33.9 and the male-female ratio is 3/2. The most frequent admission to the emergency room was in the summer. In our data, there were significant differences in age, gunshot wounds in the trauma mechanism, soft tissue injury and contusion in lesions, and spinal trauma. \u0000Conclusion: The Covid pandemic has caused imperative changes in every aspect of life. This situation also caused a change in the reasons for applying to hospitals. It has been shown that the isolations performed because of Covid-19 did not affect the diagnosis, treatment, and mortality of the patients, although they changed the mechanisms of head and spine trauma. Even with compulsory isolation for public health, the approach to neurosurgical traumas that may occur should not change. It should not be forgotten that in the presence of the Covid 19 pandemic, it continues in other clinical situations.","PeriodicalId":10750,"journal":{"name":"Cumhuriyet medical journal","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89523212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Başak Ünver Koluman, Muhammet Arslan, E. Başaran, E. P. Eser, H. Özdoğu
Ascites is an unusual finding of multiple myeloma. It is a sign of poor prognosis and can be seen not only at the initial diagnosis, but also at any stage of the disease. In this case report, we present the peritoneal involvement of a relapsed refractory multiple myeloma patient with Ig G lambda type. The patient was prescribed 2 cycles of lenalidomide (15 mg) and dexamethasone (20 mg). However, the patient did not respond to treatment.
腹水是多发性骨髓瘤的罕见表现。这是预后不良的标志，不仅在最初诊断时可以看到，而且在疾病的任何阶段都可以看到。在这个病例报告中，我们提出了一个复发的难治性多发性骨髓瘤患者与Ig G λ型腹膜受累。患者给予来那度胺(15mg)和地塞米松(20mg)治疗2个周期。然而，患者对治疗没有反应。
{"title":"A Multiple myeloma case with ascites","authors":"Başak Ünver Koluman, Muhammet Arslan, E. Başaran, E. P. Eser, H. Özdoğu","doi":"10.7197/cmj.947488","DOIUrl":"https://doi.org/10.7197/cmj.947488","url":null,"abstract":"Ascites is an unusual finding of multiple myeloma. It is a sign of poor prognosis and can be seen not only at the initial diagnosis, but also at any stage of the disease. In this case report, we present the peritoneal involvement of a relapsed refractory multiple myeloma patient with Ig G lambda type. The patient was prescribed 2 cycles of lenalidomide (15 mg) and dexamethasone (20 mg). However, the patient did not respond to treatment.","PeriodicalId":10750,"journal":{"name":"Cumhuriyet medical journal","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73524200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: In women of reproductive age, polycystic ovary syndrome (PCOS) is the most prevalent cause of infertility. The purpose of this study is to compare the Bcl-2 and Ki-67 values between infertile patients with and without PCOS. Material and methods: The study included twenty-seven infertile patients diagnosed with PCOS and another twenty-eight infertile patients who did not meet the criteria for PCOS. Smoking, pelvic infection symptoms, endometrial polyps and submucosal myomas during a transvaginal ultrasound, pituitary insufficiency, hyperprolactinemia, congenital adrenal hyperplasia, having had adnexal surgery and having a male factor that will result in infertility are all considered exclusion criteria. All patients' data were collected, including age, the length of their infertility, body mass index (BMI), waist-to-hip ratio (WHR), hirsutism score, blood pressure, total testosterone, triglyceride, total cholesterol, LDL, and HDL values, as well as Homa-IR and Hs-CRP readings. The pathology specialist in the examples evaluated Bcl-2 and Ki-67 levels. Results: We found that BMI, WHR, total testosterone level, blood pressure, total cholesterol, HOMA-IR, and hs-CRP values were significantly higher in infertile cases with PCOS. We also found that the Ki-67 and Bcl-2 values were higher in endometrial cells in sterile PCOS cases than in the control group. Conclusions: Ki-67 and Bcl-2 levels rise in PCOS patients, preventing apoptosis, limiting the formation of a suitable endometrial environment, and preventing embryo implantation. PCOS patients may frequently experience infertility and recurrent pregnancy losses. The cause of this problem may be the increased activity of estrogen. The primary treatment for PCOS will depend on further investigation into the variables affecting estrogen synthesis and GnRH release. The care plan should be built around this goal.
{"title":"EVALUATION OF ENDOMETRIAL Bcl-2 EXPRESSION AND Ki-67 PROLIFERATIVE INDEX IN INFERTILE PATIENTS WITH AND WITHOUT POLYCYSTIC OVARY SYNDROME","authors":"Dilay Karademir, A. Usta, E. Altun","doi":"10.7197/cmj.1250217","DOIUrl":"https://doi.org/10.7197/cmj.1250217","url":null,"abstract":"Objective: In women of reproductive age, polycystic ovary syndrome (PCOS) is the most prevalent cause of infertility. The purpose of this study is to compare the Bcl-2 and Ki-67 values between infertile patients with and without PCOS. \u0000Material and methods: The study included twenty-seven infertile patients diagnosed with PCOS and another twenty-eight infertile patients who did not meet the criteria for PCOS. Smoking, pelvic infection symptoms, endometrial polyps and submucosal myomas during a transvaginal ultrasound, pituitary insufficiency, hyperprolactinemia, congenital adrenal hyperplasia, having had adnexal surgery and having a male factor that will result in infertility are all considered exclusion criteria. All patients' data were collected, including age, the length of their infertility, body mass index (BMI), waist-to-hip ratio (WHR), hirsutism score, blood pressure, total testosterone, triglyceride, total cholesterol, LDL, and HDL values, as well as Homa-IR and Hs-CRP readings. The pathology specialist in the examples evaluated Bcl-2 and Ki-67 levels. \u0000Results: We found that BMI, WHR, total testosterone level, blood pressure, total cholesterol, HOMA-IR, and hs-CRP values were significantly higher in infertile cases with PCOS. We also found that the Ki-67 and Bcl-2 values were higher in endometrial cells in sterile PCOS cases than in the control group. \u0000Conclusions: Ki-67 and Bcl-2 levels rise in PCOS patients, preventing apoptosis, limiting the formation of a suitable endometrial environment, and preventing embryo implantation. PCOS patients may frequently experience infertility and recurrent pregnancy losses. The cause of this problem may be the increased activity of estrogen. The primary treatment for PCOS will depend on further investigation into the variables affecting estrogen synthesis and GnRH release. The care plan should be built around this goal.","PeriodicalId":10750,"journal":{"name":"Cumhuriyet medical journal","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88694428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: The new type of Coronavirus (SARS-CoV-2) damages cells by using the angiotensin converting enzyme-2 (ACE2) as a receptor to adhere and go through the cell membrane. It is known that some of the endocrine organs express ACE2 and these organs are potential targets for Coronavirus 2019 disease (Covid-19). This study aimed to investigate the effect of coronavirus disease 2019 (Covid-19) on Fluorine-18 fluorodeoxyglucose (18F-FDG) uptake of endocrine system organs. Methods: Sixteen patients who had Covid-19 underwent 18F-FDG positron emission tomography/computed tomography (PET/CT) later, 77 patients who did not have Covid-19 underwent 18F-FDG PET/CT between March 2020-October 2021 were analyzed finally. SUVmax and SUVmean of the pituitary, thyroid, adrenal gland, pancreas, and testis measured from the PET/CT of the patients had Covid-19 were compared with SUVmax, and SUVmean measured from the same organs in PET/CT images of the patients who had not Covid-19. Results: Pancreatic mean SUVmax was significantly higher in patients who had Covid-19 than in patients who did not (p= 0.035). Pancreatic mean SUVmean was slightly higher in patients who had Covid-19 than in patients who did not, but this difference was not statistically significant (p= 0.072). No significant difference was found between the SUVmax and SUVmean values of the pituitary gland, thyroid gland, adrenal gland, and testis in patients who had Covid-19 and did not have. Conclusions: It was thought that the pancreas might have been affected in the course of Covid-19 due to the higher mean SUVmean values of the pancreas in patients who had Covid- 19.
{"title":"Effect of Coronavirus Disease 2019 on Fluorine-18 fluorodeoxyglucose Uptake of Endocrine Organs","authors":"O. Bülbül, S. Göksel, Demet Nak","doi":"10.7197/cmj.1137978","DOIUrl":"https://doi.org/10.7197/cmj.1137978","url":null,"abstract":"Objective: The new type of Coronavirus (SARS-CoV-2) damages cells by using the angiotensin converting enzyme-2 (ACE2) as a receptor to adhere and go through the cell membrane. It is known that some of the endocrine organs express ACE2 and these organs are potential targets for Coronavirus 2019 disease (Covid-19). This study aimed to investigate the effect of coronavirus disease 2019 (Covid-19) on Fluorine-18 fluorodeoxyglucose (18F-FDG) uptake of endocrine system organs. \u0000Methods: Sixteen patients who had Covid-19 underwent 18F-FDG positron emission tomography/computed tomography (PET/CT) later, 77 patients who did not have Covid-19 underwent 18F-FDG PET/CT between March 2020-October 2021 were analyzed finally. SUVmax and SUVmean of the pituitary, thyroid, adrenal gland, pancreas, and testis measured from the PET/CT of the patients had Covid-19 were compared with SUVmax, and SUVmean measured from the same organs in PET/CT images of the patients who had not Covid-19. \u0000Results: Pancreatic mean SUVmax was significantly higher in patients who had Covid-19 than in patients who did not (p= 0.035). Pancreatic mean SUVmean was slightly higher in patients who had Covid-19 than in patients who did not, but this difference was not statistically significant (p= 0.072). No significant difference was found between the SUVmax and SUVmean values of the pituitary gland, thyroid gland, adrenal gland, and testis in patients who had Covid-19 and did not have. \u0000Conclusions: It was thought that the pancreas might have been affected in the course of Covid-19 due to the higher mean SUVmean values of the pancreas in patients who had Covid- 19.","PeriodicalId":10750,"journal":{"name":"Cumhuriyet medical journal","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90444819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Rheumatoid arthritis (RA) is an autoimmune disease associated with systemic inflammation. Laboratory parameters such as erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and various disease evaluation indexes (such as DAS 28; HAQ, SF-36) are used as indicators of the severity of inflammatory activity. Neutrophil-to-lymphocyte ratio (NLR); It has attracted attention in recent years as a non-specific inflammatory marker. In our study, it was aimed to investigate the possible role of peripheral blood NLR, which is easy and inexpensive to measure, in demonstrating disease activity and prognosis in patients with RA. Materials and Methods: Forty-three patients who were diagnosed with RA according to the criteria of the American Rheumatology Association and who had not received prior specific treatment for RA were included in the study. Laboratory parameters such as ESR, CRP, and disease assessment indices (DAS 28; HAQ) were compared with the NLR at the time of diagnosis and at the time of enrollment after treatment. Results: There were no significant correlation found between the mean NLR and DAS 28, HAQ which provide information about the prognosis of the disease. When the relationship between NLR and ESR and CRP was examined in order to evaluate the relatonship between the disease activity and inflamation during the diagnosis instead of a composite index such as DAS 28, moderately weak relationship between NLR and CRP level was found (p=0.033, r=0,343) while the tendency between NLR and the average ESR was found to be also moderately weak (p=0.056, r=0.301). Conclusions: Moderate to weak correlation between mean NLR and mean CRP levels (p=0.033, r=0.343); between the mean ESR level, a moderate-weak correlation was found (p=0.056, r=0.301). The association with baseline CRP and the trend towards association with ESR suggest that NLR may be associated with inflammation. It was thought that the loss of this relationship during the study, that is, after the treatment, may be due to the fact that other factors such as medication affect this rate.
{"title":"THE RELATIONSHIP OF NEUTROPHIL LYMPHOCYTE RATIO WITH PROGNOSIS AND DISEASE ACTIVITY IN PATIENTS WITH RHEUMATOID ARTHRITIS","authors":"Gülten Korkmaz, M. Özmen, G. Can, E. Tarhan","doi":"10.7197/cmj.1175878","DOIUrl":"https://doi.org/10.7197/cmj.1175878","url":null,"abstract":"Background: Rheumatoid arthritis (RA) is an autoimmune disease associated with systemic inflammation. Laboratory parameters such as erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and various disease evaluation indexes (such as DAS 28; HAQ, SF-36) are used as indicators of the severity of inflammatory activity. Neutrophil-to-lymphocyte ratio (NLR); It has attracted attention in recent years as a non-specific inflammatory marker. In our study, it was aimed to investigate the possible role of peripheral blood NLR, which is easy and inexpensive to measure, in demonstrating disease activity and prognosis in patients with RA. \u0000 \u0000Materials and Methods: Forty-three patients who were diagnosed with RA according to the criteria of the American Rheumatology Association and who had not received prior specific treatment for RA were included in the study. Laboratory parameters such as ESR, CRP, and disease assessment indices (DAS 28; HAQ) were compared with the NLR at the time of diagnosis and at the time of enrollment after treatment. \u0000 \u0000Results: There were no significant correlation found between the mean NLR and DAS 28, HAQ which provide information about the prognosis of the disease. When the relationship between NLR and ESR and CRP was examined in order to evaluate the relatonship between the disease activity and inflamation during the diagnosis instead of a composite index such as DAS 28, moderately weak relationship between NLR and CRP level was found (p=0.033, r=0,343) while the tendency between NLR and the average ESR was found to be also moderately weak (p=0.056, r=0.301). \u0000 \u0000Conclusions: Moderate to weak correlation between mean NLR and mean CRP levels (p=0.033, r=0.343); between the mean ESR level, a moderate-weak correlation was found (p=0.056, r=0.301). The association with baseline CRP and the trend towards association with ESR suggest that NLR may be associated with inflammation. It was thought that the loss of this relationship during the study, that is, after the treatment, may be due to the fact that other factors such as medication affect this rate.","PeriodicalId":10750,"journal":{"name":"Cumhuriyet medical journal","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79950981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Ahbab, A. Keskin, Emre Hoca, E. Ataoğlu, T. Can, Fatih Türker, Betül Çavuşoğlu
Objective: Fat accumulation in the liver and pancreas are clinical manifestations of metabolic syndrome and associated with inflammation. It was aimed to investigate the effects of the computed tomography (CT) estimated non-alcoholic fatty liver disease (NAFLD) and non-alcoholic fatty pancreas disease (NAFPD) on the development of acute pancreatitis in this study. Patients and methods: This retrospective and cross sectional study was consisted of 194 participants who admitted to the hospital with an abdominal pain complaint and undergone an abdominal CT scan during the investigation of the differential diagnosis. Medical database records of patients were investigated. Groups were consisted of according to the presence of acute pancreatitis as study and control. Attenuation measurements of liver and pancreas were determined according to abdominal CT. Results: A statistical significance was observed for the development of acute pancreatitis when patients with normoglycemia were compared to both patients with prediabetes and diabetes. Percentages of NAFLD and NAFPD according to the median of CT attenuation difference between pancreas and spleen values were elevated in the study group. A logistic regression model was revealed that prediabetes, type 2 diabetes, NAFLD and NAFPD according to median value were risk factors for the acute pancreatitis (p
{"title":"Non-Alcoholic Fatty Liver and Fatty Pancreas Diseases Associate with Acute Pancreatitis","authors":"S. Ahbab, A. Keskin, Emre Hoca, E. Ataoğlu, T. Can, Fatih Türker, Betül Çavuşoğlu","doi":"10.7197/cmj.1079443","DOIUrl":"https://doi.org/10.7197/cmj.1079443","url":null,"abstract":"Objective: Fat accumulation in the liver and pancreas are clinical manifestations of metabolic syndrome and associated with inflammation. It was aimed to investigate the effects of the computed tomography (CT) estimated non-alcoholic fatty liver disease (NAFLD) and non-alcoholic fatty pancreas disease (NAFPD) on the development of acute pancreatitis in this study. \u0000Patients and methods: This retrospective and cross sectional study was consisted of 194 participants who admitted to the hospital with an abdominal pain complaint and undergone an abdominal CT scan during the investigation of the differential diagnosis. Medical database records of patients were investigated. Groups were consisted of according to the presence of acute pancreatitis as study and control. Attenuation measurements of liver and pancreas were determined according to abdominal CT. \u0000Results: A statistical significance was observed for the development of acute pancreatitis when patients with normoglycemia were compared to both patients with prediabetes and diabetes. Percentages of NAFLD and NAFPD according to the median of CT attenuation difference between pancreas and spleen values were elevated in the study group. A logistic regression model was revealed that prediabetes, type 2 diabetes, NAFLD and NAFPD according to median value were risk factors for the acute pancreatitis (p","PeriodicalId":10750,"journal":{"name":"Cumhuriyet medical journal","volume":"118 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89741494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Ergenç, Z. Ertürk, Özlem KARACA OCAK, Feyzi Gökosmanoğlu
Objectives: This study aimed to investigate the effects of non-alcoholic fatty liver disease on thyroid nodule prevalence Methods: A total of 384 patients who were followed up with Grade 2-3 Non-Alcoholic Fatty Liver diagnosis were investigated for the presence of multinodular and/or nodular goiter. Demographic characteristics, biochemical data, and abdominal and thyroid ultrasonography reports of the patients were collected from patient files and electronic records. Results: The ALT (cut-off level 10-40 U/L), GGT (cut-level 0 - 65 U / L), triglyceride (0-150 mg/dL), homeostasis model assessment of insulin resistance (HOMA-IR index value < 2.71), and TSH (cut-off level 0.45-4.12 mU / L), which are biochemical and metabolic parameters examined in our study, increased at statistically significant levels as the fat increased in the liver. A total of 45.8% (176/384) of the patients had Grade-2 Non-Alcoholic Fatty Liver Disease, and 54.1% (208/384) had Grade-3 Non-Alcoholic Fatty Liver Disease. As fat increased in the Non-Alcoholic Fatty Liver Disease, the prevalence of nodules increased at statistically significant levels (p=0.001). Conclusion: Our study found that the frequency of thyroid nodules, disruption of the parenchymal structure, and metabolic and biochemical disruption are parallel in non-Alcoholic fatty liver patients.
目的:本研究旨在探讨非酒精性脂肪肝对甲状腺结节患病率的影响。方法:对384例诊断为2-3级非酒精性脂肪肝的患者进行多结节性和/或结节性甲状腺肿的随访。从患者档案和电子记录中收集患者的人口学特征、生化数据、腹部和甲状腺超声报告。结果:我们研究的生化和代谢参数ALT(临界值10-40 U/L)、GGT(临界值0- 65 U/L)、甘油三酯(0-150 mg/dL)、胰岛素抵抗稳态模型评估(HOMA-IR指数< 2.71)和TSH(临界值0.45-4.12 mU /L)随着肝脏脂肪的增加而升高，且具有统计学意义。45.8%(176/384)的患者为2级非酒精性脂肪肝，54.1%(208/384)的患者为3级非酒精性脂肪肝。随着非酒精性脂肪性肝病患者脂肪的增加，结节的患病率也在显著水平上增加(p=0.001)。结论:我们的研究发现，在非酒精性脂肪肝患者中，甲状腺结节的发生频率、实质结构的破坏以及代谢和生化的破坏是平行的。
{"title":"Thyroid Nodule Prevalence in Non-Alcoholic Fatty Liver","authors":"H. Ergenç, Z. Ertürk, Özlem KARACA OCAK, Feyzi Gökosmanoğlu","doi":"10.7197/cmj.1088088","DOIUrl":"https://doi.org/10.7197/cmj.1088088","url":null,"abstract":"Objectives: This study aimed to investigate the effects of non-alcoholic fatty liver disease on thyroid nodule prevalence \u0000Methods: A total of 384 patients who were followed up with Grade 2-3 Non-Alcoholic Fatty Liver diagnosis were investigated for the presence of multinodular and/or nodular goiter. Demographic characteristics, biochemical data, and abdominal and thyroid ultrasonography reports of the patients were collected from patient files and electronic records. \u0000Results: The ALT (cut-off level 10-40 U/L), GGT (cut-level 0 - 65 U / L), triglyceride (0-150 mg/dL), homeostasis model assessment of insulin resistance (HOMA-IR index value < 2.71), and TSH (cut-off level 0.45-4.12 mU / L), which are biochemical and metabolic parameters examined in our study, increased at statistically significant levels as the fat increased in the liver. A total of 45.8% (176/384) of the patients had Grade-2 Non-Alcoholic Fatty Liver Disease, and 54.1% (208/384) had Grade-3 Non-Alcoholic Fatty Liver Disease. As fat increased in the Non-Alcoholic Fatty Liver Disease, the prevalence of nodules increased at statistically significant levels (p=0.001). \u0000Conclusion: Our study found that the frequency of thyroid nodules, disruption of the parenchymal structure, and metabolic and biochemical disruption are parallel in non-Alcoholic fatty liver patients.","PeriodicalId":10750,"journal":{"name":"Cumhuriyet medical journal","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83352887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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