Background/Aims: To compare CTGF (connective tissue growth factor) and P2/MS [platelet count (109 / L)] 2 / [monocyte fraction (%) x segment neutrophil fraction (%)] ratio as non-invasive tests with liver biopsy in the detection of liver fibrosis. Thus, to determine whether CTGF and P2/MS index results can be used as a noninvasive marker, in the diagnosis of chronic liver disease Materials and Methods: A total of 52 chronic hepatitis patients with concurrent liver biopsy (27 female, 25 male) were included in the study group. The subjects' ages ranged between 18 and 70, and none of the subjects had undergone liver disease-related treatment. The control group was made up of a total of 31 healthy individuals without liver disease (18 female, 13 male) from similar age groups. Liver biopsy results of patients were reported at 7 stages according to Modified Knodell Scoring (ISHAK). Results: CTGF levels were higher in patients with chronic hepatitis (1.06±0.70 ng/ml) than the control group (0,72±0,32 ng/ml) (P
{"title":"Comparison and Evaluation of CTGF and P2/MS as Noninvasive Markers in Fibrosis Evaluation in Chronic Liver Disease","authors":"S. Çiftel, H. Ataseven, S. Çiftel, A. Altun","doi":"10.7197/cmj.1212431","DOIUrl":"https://doi.org/10.7197/cmj.1212431","url":null,"abstract":"Background/Aims: To compare CTGF (connective tissue growth factor) and P2/MS [platelet count (109 / L)] 2 / [monocyte fraction (%) x segment neutrophil fraction (%)] ratio as non-invasive tests with liver biopsy in the detection of liver fibrosis. Thus, to determine whether CTGF and P2/MS index results can be used as a noninvasive marker, in the diagnosis of chronic liver disease \u0000Materials and Methods: A total of 52 chronic hepatitis patients with concurrent liver biopsy (27 female, 25 male) were included in the study group. The subjects' ages ranged between 18 and 70, and none of the subjects had undergone liver disease-related treatment. The control group was made up of a total of 31 healthy individuals without liver disease (18 female, 13 male) from similar age groups. Liver biopsy results of patients were reported at 7 stages according to Modified Knodell Scoring (ISHAK). \u0000Results: CTGF levels were higher in patients with chronic hepatitis (1.06±0.70 ng/ml) than the control group (0,72±0,32 ng/ml) (P","PeriodicalId":10750,"journal":{"name":"Cumhuriyet medical journal","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87191394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Amygdalin, which is part of the aromatic cyanogenic glycoside group, is found in plant seeds such as apricot, peach, plum, apple, pear, and cherry. It has been shown that amygdalin has anti-tumor properties against many cancers such as colon, breast, and lung cancer. This study aimed to determine the cytotoxic and anticytotoxic effects of amygdalin in human colon cancer cells (DLD-1) and normal colonic epithelium (CCD-18Co) using the MTT (3-(4,5-dimethylthiazol-2-YL)-2,5-diphenyltetrazolium bromide) test. Materials and Methods: DLD-1 and CCD-18Co cells were grown in flasks containing Roswell Park Memorial Institute-1640 and Eagle's Minimum Essential Medium, respectively. Both cell groups were treated with amygdalin concentrations of 100, 50, 25, 12.5, 6.25, 3.125, and 1.56 mM for 24 hours. Then, 20% MTT dye was added to the wells of the aspirated plates and incubated for 3 hours. After the reaction was stopped with pure DMSO at the end of the period, the absorbance values of the plates were read spectrophotometrically at a wavelength of 570 nm. Results: The percent viability values for the DLD-1 cell line were found to be between 48.3-71.6% and the IC50 value was calculated as 74.03 mM. The viability values for the CCD-18Co cell line after the amygdalin treatment ranged from 101.6 to 117.9%. Conclusion: While amygdalin showed a cytotoxic effect in the DLD-1 cell line, it showed an anticytotoxic effect in the CCD-18Co cell line. In our study, it was determined that amygdalin decreased the viability of DLD-1 cancer cells in a dose-dependent manner and did not show cytotoxic effects on CCD18-Co normal epithelial cells. More comprehensive controlled clinical trials are needed to demonstrate the feasibility of using amygdalin in combination with other anti-tumor drugs and to develop the artificial synthesis of the active ingredients in amygdalin in order to increase the anti-tumor activities of these drugs.
目的:苦杏仁苷是一种芳香氰苷类化合物，存在于杏、桃、李、苹果、梨、樱桃等植物种子中。研究表明，苦杏仁苷具有抗肿瘤特性，可以对抗许多癌症，如结肠癌、乳腺癌和肺癌。本研究旨在通过MTT(3-(4,5-二甲基噻唑-2- yl)-2,5-二苯基溴化四唑)试验，检测苦杏仁苷对人结肠癌细胞(DLD-1)和正常结肠上皮细胞(CCD-18Co)的细胞毒和抗细胞毒作用。材料和方法:DLD-1和CCD-18Co细胞分别生长在含有Roswell Park Memorial Institute-1640和Eagle's Minimum Essential Medium的烧瓶中。两组细胞分别用浓度为100、50、25、12.5、6.25、3.125和1.56 mM的苦杏仁苷处理24小时。然后在抽吸板孔中加入20% MTT染料，孵育3小时。在反应结束时用纯DMSO停止反应后，分光光度法在波长570nm处读取板的吸光度值。结果:DLD-1细胞株的存活率为48.3 ~ 71.6%，IC50为74.03 mM，苦杏仁苷处理后的CCD-18Co细胞株的存活率为101.6 ~ 117.9%。结论:苦杏仁苷对DLD-1细胞株具有细胞毒作用，对CCD-18Co细胞株具有抗细胞毒作用。在我们的研究中，我们确定苦杏仁苷以剂量依赖的方式降低DLD-1癌细胞的活力，而对CCD18-Co正常上皮细胞没有细胞毒性作用。苦杏仁苷与其他抗肿瘤药物联合使用的可行性，以及开发苦杏仁苷中有效成分的人工合成，以提高这些药物的抗肿瘤活性，还需要更全面的对照临床试验来证明。
{"title":"DETERMINATION OF CYTOTOXIC EFFECT OF AMYGDALIN IN DLD-1 CELL LINE AND ANTICYTOTOXIC EFFECT IN CCD-18CO CELL LINE","authors":"Alpaslan Öztürk, Aybüke Afra Keski̇ner, Berna Kocaman, Ece AVULOĞLU YILMAZ","doi":"10.7197/cmj.1185366","DOIUrl":"https://doi.org/10.7197/cmj.1185366","url":null,"abstract":"Objective: Amygdalin, which is part of the aromatic cyanogenic glycoside group, is found in plant seeds such as apricot, peach, plum, apple, pear, and cherry. It has been shown that amygdalin has anti-tumor properties against many cancers such as colon, breast, and lung cancer. This study aimed to determine the cytotoxic and anticytotoxic effects of amygdalin in human colon cancer cells (DLD-1) and normal colonic epithelium (CCD-18Co) using the MTT (3-(4,5-dimethylthiazol-2-YL)-2,5-diphenyltetrazolium bromide) test. \u0000Materials and Methods: DLD-1 and CCD-18Co cells were grown in flasks containing Roswell Park Memorial Institute-1640 and Eagle's Minimum Essential Medium, respectively. Both cell groups were treated with amygdalin concentrations of 100, 50, 25, 12.5, 6.25, 3.125, and 1.56 mM for 24 hours. Then, 20% MTT dye was added to the wells of the aspirated plates and incubated for 3 hours. After the reaction was stopped with pure DMSO at the end of the period, the absorbance values of the plates were read spectrophotometrically at a wavelength of 570 nm. \u0000Results: The percent viability values for the DLD-1 cell line were found to be between 48.3-71.6% and the IC50 value was calculated as 74.03 mM. The viability values for the CCD-18Co cell line after the amygdalin treatment ranged from 101.6 to 117.9%. \u0000Conclusion: While amygdalin showed a cytotoxic effect in the DLD-1 cell line, it showed an anticytotoxic effect in the CCD-18Co cell line. In our study, it was determined that amygdalin decreased the viability of DLD-1 cancer cells in a dose-dependent manner and did not show cytotoxic effects on CCD18-Co normal epithelial cells. More comprehensive controlled clinical trials are needed to demonstrate the feasibility of using amygdalin in combination with other anti-tumor drugs and to develop the artificial synthesis of the active ingredients in amygdalin in order to increase the anti-tumor activities of these drugs.","PeriodicalId":10750,"journal":{"name":"Cumhuriyet medical journal","volume":"62 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83872797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Problems such as changes in people's lifestyles and standards and environmental pollution have seriously affected human health. It is known that many substances that people eat, drink, use in daily life and are exposed to are harmful to human health. At the beginning of these substances are the substances called “chemicals”. The use of these chemicals has accelerated with the development of industry and technology. It has been determined that many chemicals, which were previously considered harmless, cause diseases, irreversible damages and deterioration of the genetic structure over time. Cancer is one of the diseases caused by these chemicals. In the cancer statistics of 2020, it has been reported that there are 201 cases of cancer in every 100 thousand people in the world. Despite all the successes in the diagnosis, treatment and prevention of cancer in recent years; unfortunately, the war waged by scientists against cancer has not been fully won yet. In this study, the relationship between cancer and chemicals that are frequently used in daily life without being aware of it are discussed.
{"title":"CONTACT WITH HARMFUL CHEMICALS AND CANCER","authors":"Gamze TOPAL CANBAZ","doi":"10.7197/cmj.1180976","DOIUrl":"https://doi.org/10.7197/cmj.1180976","url":null,"abstract":"Problems such as changes in people's lifestyles and standards and environmental pollution have seriously affected human health. It is known that many substances that people eat, drink, use in daily life and are exposed to are harmful to human health. At the beginning of these substances are the substances called “chemicals”. The use of these chemicals has accelerated with the development of industry and technology. It has been determined that many chemicals, which were previously considered harmless, cause diseases, irreversible damages and deterioration of the genetic structure over time. \u0000Cancer is one of the diseases caused by these chemicals. In the cancer statistics of 2020, it has been reported that there are 201 cases of cancer in every 100 thousand people in the world. Despite all the successes in the diagnosis, treatment and prevention of cancer in recent years; unfortunately, the war waged by scientists against cancer has not been fully won yet. In this study, the relationship between cancer and chemicals that are frequently used in daily life without being aware of it are discussed.","PeriodicalId":10750,"journal":{"name":"Cumhuriyet medical journal","volume":"60 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84399537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cevdet Düger, Onur Avcı, A. Boztosun, C. Isbir, İclal Özdemir Kol, K. Kaygusuz, S. Gürsoy
Study Objective: In this study we aimed to determine whether iliohypogastric and ilioinguinal nerve blockade from intraabdominal approach for the postoperative pain management of total abdominal hysterectomy patients could be a reliable and effective alternative compared to percutaneous block of IHII nerves. Design: This study is a randomised controlled double blind prospective clinical trial. Setting: This study was conducted in operating room, and recordings were performed in postoperative recovery unit and gynaecology clinic. Patients: Eighty seven women undergoing total abdominal hysterectomy were enrolled in this study but 82 completed the study. Patients were divided into three groups (n=29 in each), as control group (group C), percutaneous IHII block group (group PB) and intraabdominal IHII block group (group IB). Interventions: Group C patients received no block procedure. The percutaneous bilateral IHII nerves block was performed after abdominal closure to group PB and intraabdominal IHII block was performed before abdominal closure to group IB. Measurements: Mean arterial pressure, heart rate, pain scores, satisfaction scores, morphine consumptions and side effects were recorded at the 2nd, 6th, 12th and 24th postoperative hours. Main Results: Postoperative MAP, HR results of control group were found similar in all groups. VAS scores at all postoperative hours were found to be significantly lower in the block groups PB an IB than control group. There were no significant differences in pain scores between group PB and IB at any time point. Morphine consumption data were found to be significantly lower in the PB and IB groups than in the control group. Conclusions: Intraabdominal IHII blockade just before closure of the abdomen for relieving postoperative pain in total abdominal hysterectomy patients is as effective and safe method as conventional percutaneous IHII blockade without adverse effects.
{"title":"COMPARISON OF PERCUTANEOUS AND INTRAABDOMINAL BLOCKADES OF ILIOHYPOGASTRIC AND ILIOINGUINAL NERVES FOR POSTOPERATIVE PAIN MANAGEMENT OF TOTAL ABDOMINAL HYSTERECTOMY PATIENTS: A RANDOMIZED CONTROLLED CLINICAL TRIAL","authors":"Cevdet Düger, Onur Avcı, A. Boztosun, C. Isbir, İclal Özdemir Kol, K. Kaygusuz, S. Gürsoy","doi":"10.7197/cmj.1167647","DOIUrl":"https://doi.org/10.7197/cmj.1167647","url":null,"abstract":"Study Objective: In this study we aimed to determine whether iliohypogastric and ilioinguinal nerve blockade from intraabdominal approach for the postoperative pain management of total abdominal hysterectomy patients could be a reliable and effective alternative compared to percutaneous block of IHII nerves. \u0000Design: This study is a randomised controlled double blind prospective clinical trial. \u0000Setting: This study was conducted in operating room, and recordings were performed in postoperative recovery unit and gynaecology clinic. \u0000Patients: Eighty seven women undergoing total abdominal hysterectomy were enrolled in this study but 82 completed the study. Patients were divided into three groups (n=29 in each), as control group (group C), percutaneous IHII block group (group PB) and intraabdominal IHII block group (group IB). \u0000Interventions: Group C patients received no block procedure. The percutaneous bilateral IHII nerves block was performed after abdominal closure to group PB and intraabdominal IHII block was performed before abdominal closure to group IB. \u0000Measurements: Mean arterial pressure, heart rate, pain scores, satisfaction scores, morphine consumptions and side effects were recorded at the 2nd, 6th, 12th and 24th postoperative hours. \u0000Main Results: Postoperative MAP, HR results of control group were found similar in all groups. VAS scores at all postoperative hours were found to be significantly lower in the block groups PB an IB than control group. There were no significant differences in pain scores between group PB and IB at any time point. Morphine consumption data were found to be significantly lower in the PB and IB groups than in the control group. \u0000Conclusions: Intraabdominal IHII blockade just before closure of the abdomen for relieving postoperative pain in total abdominal hysterectomy patients is as effective and safe method as conventional percutaneous IHII blockade without adverse effects.","PeriodicalId":10750,"journal":{"name":"Cumhuriyet medical journal","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76449352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Finger amputations are the most commonly encountered amputation injury in the upper extremities. It is important to avoid shortening and to preserve the length of the finger in fingertip amputations in order not to lose the functions of the hand. The aim of this study was to evaluate the results of our patients who underwent reconstruction using V-Y pulp flap and artificial nail in order to avoid donor site morbidity in fingertip defects. Methods: The results of patients who underwent reparation with V-Y flap and polyethylene nails for exposed distal phalanx and partial nail bed defect after fingertip amputation were evaluated in this retrospective study. The data of 44 patients who underwent 44 V-Y advancement flap between January 2016 and January 2021 were retrospectively analyzed. Results: A total of 44 patients, 5 female and 39 male, who were treated for fingertip amputation, with a mean follow-up period of 24.2 months (14-71) and a mean age of 34.75 (2-68) were included in the study. The mechanism of injury was guillotine-style, avulsion and crush injuries in 15 (34.1%), 11 (25%) and 18 (40.9%) patients, respectively. Among the patients, 25 (56.8%) had right hand injuries, while 19 (43.2%) had left hand injuries. The dominant hand was affected in 28 (63.6%) patients. In 5 patients, the distal phalanx was shortened to the level of the lost nail bed (shortening was maximum 5 mm). Nail formation had occurred in all patients and deformed nail structure was seen in 18 patients. Graft necrosis was seen in 2 patients. Conclusion: It is difficult for surgeons to decide on the treatment method because of the fact that there are multiple surgical techniques in the literature and the results are reported differently. Success rates are high in our technique. Each techniq.ue has its own advantages and disadvantages.
{"title":"Fingertip Amputations Repair with V-Y Flap and Polyethylene Nail","authors":"B. Özdemi̇r, Tarık Elma","doi":"10.7197/cmj.1201371","DOIUrl":"https://doi.org/10.7197/cmj.1201371","url":null,"abstract":"Background: Finger amputations are the most commonly encountered amputation injury in the upper extremities. It is important to avoid shortening and to preserve the length of the finger in fingertip amputations in order not to lose the functions of the hand. The aim of this study was to evaluate the results of our patients who underwent reconstruction using V-Y pulp flap and artificial nail in order to avoid donor site morbidity in fingertip defects. \u0000Methods: The results of patients who underwent reparation with V-Y flap and polyethylene nails for exposed distal phalanx and partial nail bed defect after fingertip amputation were evaluated in this retrospective study. The data of 44 patients who underwent 44 V-Y advancement flap between January 2016 and January 2021 were retrospectively analyzed. \u0000Results: A total of 44 patients, 5 female and 39 male, who were treated for fingertip amputation, with a mean follow-up period of 24.2 months (14-71) and a mean age of 34.75 (2-68) were included in the study. The mechanism of injury was guillotine-style, avulsion and crush injuries in 15 (34.1%), 11 (25%) and 18 (40.9%) patients, respectively. Among the patients, 25 (56.8%) had right hand injuries, while 19 (43.2%) had left hand injuries. The dominant hand was affected in 28 (63.6%) patients. In 5 patients, the distal phalanx was shortened to the level of the lost nail bed (shortening was maximum 5 mm). Nail formation had occurred in all patients and deformed nail structure was seen in 18 patients. Graft necrosis was seen in 2 patients. \u0000Conclusion: It is difficult for surgeons to decide on the treatment method because of the fact that there are multiple surgical techniques in the literature and the results are reported differently. Success rates are high in our technique. Each techniq.ue has its own advantages and disadvantages.","PeriodicalId":10750,"journal":{"name":"Cumhuriyet medical journal","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78957951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mustafa Karademir, Ezgi Agadayi, S. Karahan, Dilay Karademir
Aim: Our aim in this study is to determine the perceptions of medical residency students studying at a university about the hospital education environment and the factors affecting it. Methods: This was a descriptive study. The population of the research consisted of specialty students studying at Sivas Cumhuriyet University. The research questionnaire was sent to the participants via text message to their personal mobile phone numbers. Informed consent was obtained from the participants on the first page of the survey link sent to them. The data collection tool used in the study included a total of 71 questions. The first part was created by the researchers through literature review and included 31 questions. The other 40 questions were Postgraduate Hospital Educational Environment Measure (PHEEM). Results: 266 of the 387 residency students in the faculty participated in the survey (Response rate: 68.7%). 79% of residency students studying in medical sciences and 56% in surgical sciences participated in the research. 11.7% (n=23) of residents from medical sciences and 28.6% (n=20) of residents from surgical sciences stated that no seminar hours were held. Postgraduate Hospital Educational Environment Measure mean score of the residency students was found to be 83.6 ± 25.5. The mean score did not differ significantly between departments (p=0.578). Those who thought that there were enough residents and faculty members had higher educational environment measure scores (respectively p=0.010 and p
{"title":"Evaluation of Medical Specialization Education Students' Perceptions of Hospital Education Environment and Affecting Factors","authors":"Mustafa Karademir, Ezgi Agadayi, S. Karahan, Dilay Karademir","doi":"10.7197/cmj.1206015","DOIUrl":"https://doi.org/10.7197/cmj.1206015","url":null,"abstract":"Aim: Our aim in this study is to determine the perceptions of medical residency students studying at a university about the hospital education environment and the factors affecting it. \u0000Methods: This was a descriptive study. The population of the research consisted of specialty students studying at Sivas Cumhuriyet University. The research questionnaire was sent to the participants via text message to their personal mobile phone numbers. Informed consent was obtained from the participants on the first page of the survey link sent to them. The data collection tool used in the study included a total of 71 questions. The first part was created by the researchers through literature review and included 31 questions. The other 40 questions were Postgraduate Hospital Educational Environment Measure (PHEEM). \u0000Results: 266 of the 387 residency students in the faculty participated in the survey (Response rate: 68.7%). 79% of residency students studying in medical sciences and 56% in surgical sciences participated in the research. 11.7% (n=23) of residents from medical sciences and 28.6% (n=20) of residents from surgical sciences stated that no seminar hours were held. Postgraduate Hospital Educational Environment Measure mean score of the residency students was found to be 83.6 ± 25.5. The mean score did not differ significantly between departments (p=0.578). Those who thought that there were enough residents and faculty members had higher educational environment measure scores (respectively p=0.010 and p","PeriodicalId":10750,"journal":{"name":"Cumhuriyet medical journal","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83036368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Beyza Bozok, Öykü Özdemir, Ayla Uzun Çiçek, H. Aksoy, I. Ucuz, Elif Abanoz
Sleep-isolated trichotillomania (TTM) is the unconscious and automatic pulling of one's hair only while sleeping. In previous case reports, sleep-isolated TTM has been categorized as a sleep-related disorder or a sleep-related dissociative disorder in case reports, and a treatment strategy in this direction has been implemented. However, to our knowledge, no reports have been published describing hair pulling during sleep as a symptom of epilepsy and its pharmacological treatment. In this case report, we present the hair-pulling behavior during sleep as an ictal manifestation of complex partial seizure in a 12-year-old girl and its successful treatment with levetiracetam. We suggest that epilepsy should be suspected in addition to parasomnias and sleep-related dissociative disorder in the differential diagnosis, especially in cases presenting with isolated TTM behavior during sleep.
{"title":"Sleep-isolated trichotillomania as an ictal symptom of complex partial seizure in a 12-year-old girl: a case report","authors":"Beyza Bozok, Öykü Özdemir, Ayla Uzun Çiçek, H. Aksoy, I. Ucuz, Elif Abanoz","doi":"10.7197/cmj.1194080","DOIUrl":"https://doi.org/10.7197/cmj.1194080","url":null,"abstract":"Sleep-isolated trichotillomania (TTM) is the unconscious and automatic pulling of one's hair only while sleeping. In previous case reports, sleep-isolated TTM has been categorized as a sleep-related disorder or a sleep-related dissociative disorder in case reports, and a treatment strategy in this direction has been implemented. However, to our knowledge, no reports have been published describing hair pulling during sleep as a symptom of epilepsy and its pharmacological treatment. In this case report, we present the hair-pulling behavior during sleep as an ictal manifestation of complex partial seizure in a 12-year-old girl and its successful treatment with levetiracetam. We suggest that epilepsy should be suspected in addition to parasomnias and sleep-related dissociative disorder in the differential diagnosis, especially in cases presenting with isolated TTM behavior during sleep.","PeriodicalId":10750,"journal":{"name":"Cumhuriyet medical journal","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77416918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Renal cell carcinomas is 2-3% of all adult cancers. Kidney cancer is currently the seventh most common cancer in men and the tenth most common in women (1). There were 19,3 million new cancer diagnoses and 10 million cancer deaths worldwide in 2020 (2). Survival in renal cell carcinomas has a strong correlation with the stage of diagnosis. 5-year survival in stage 1 tumors is 93%, 72,5% in cases with local lymph node metastases and 12% in metastatic carcinomas cases (3). There is an inverse correlation between age / tumor size and survival. Metastatic lymph node, tumor necrosis and adipose tissue invasion are associated with poor prognosis (4). The study is including 179 renal cell carcinoma cases. The clinical and pathological datas of these cases were retrospectively analyzed from the Cumhuriyet University Hospital patient system. The distribution sex of cases are 111 males (62%) and 68 females (38%). The mean age of the 179 cases was 58,5±11,9 years (range of 21-90). The mean tumor diameter is 5,7±3,4 (range of 1-19 cm). The nuclear grades of cases are 53,1% with low grade and 46,8% with high grade. Radical nephrectomies were evaluated for vascular invasion, ureter invasion, capsule/adipose tissue invasion, lymph node metastasis and adrenal gland metastasis. There is a statistically significant relationship between nuclear grade and vein invasion, microvascular invasion, capsule/adipose tissue invasion (p
{"title":"Pathological Prognostic Features and Analysis of Renal Cell Carcinoma","authors":"Sena Öztürk, Serkan Çeli̇kgün, Neşe Yeldir","doi":"10.7197/cmj.1216497","DOIUrl":"https://doi.org/10.7197/cmj.1216497","url":null,"abstract":"Renal cell carcinomas is 2-3% of all adult cancers. Kidney cancer is currently the seventh most common cancer in men and the tenth most common in women (1). There were 19,3 million new cancer diagnoses and 10 million cancer deaths worldwide in 2020 (2). \u0000Survival in renal cell carcinomas has a strong correlation with the stage of diagnosis. 5-year survival in stage 1 tumors is 93%, 72,5% in cases with local lymph node metastases and 12% in metastatic carcinomas cases (3). There is an inverse correlation between age / tumor size and survival. Metastatic lymph node, tumor necrosis and adipose tissue invasion are associated with poor prognosis (4). \u0000The study is including 179 renal cell carcinoma cases. The clinical and pathological datas of these cases were retrospectively analyzed from the Cumhuriyet University Hospital patient system. \u0000The distribution sex of cases are 111 males (62%) and 68 females (38%). The mean age of the 179 cases was 58,5±11,9 years (range of 21-90). The mean tumor diameter is 5,7±3,4 (range of 1-19 cm). The nuclear grades of cases are 53,1% with low grade and 46,8% with high grade. \u0000Radical nephrectomies were evaluated for vascular invasion, ureter invasion, capsule/adipose tissue invasion, lymph node metastasis and adrenal gland metastasis. \u0000There is a statistically significant relationship between nuclear grade and vein invasion, microvascular invasion, capsule/adipose tissue invasion (p","PeriodicalId":10750,"journal":{"name":"Cumhuriyet medical journal","volume":"106 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79287531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Onder, Derya Kıvrak Salim, M. Karaca, S. Bayram, Armağan Aydin, Sevil Göktaş, M. Koçer, Deniz ÖZBAY GEDİZ, M. Yıldız, Banu Öztürk
İntroduction and aim: Cancer affects people psychologically and organically. The emotional state of cancer patients is fragile and can be affected by many factors. We aimed to evaluate the effect of the Covid-19 pandemic on the mood and behavioral changes of cancer patients with solid cancer who are in follow-up and treatment. Material and Method: A face-to-face questionnaire was filled in solid cancer patients without known psychological disorders who applied to the Medical Oncology outpatient clinic between 1-30 September 2021. The Hospital Anxiety and Depression Scale (HADS) and the scale examining the perspectives on Covid-19 were applied to the patients whose consent was obtained. Results: A total of 235 people, 139 women and 63 men, participated in the survey. In the review of 202 completed surveys, the median age was 55 (23-83 years). In the study in which seventeen different solid cancer patients were evaluated, breast (52.5%), colon (19.3%) and lung (10.8%) cancers were most common. Most of the people who were more afraid of Covid-19 compared to cancer were patients who were on active cancer treatment. In the multivariate regression analysis, being on active treatment was found to be the only risk factor for 'being more afraid of Covid-19' compared to cancer. During Covid-19 pandemic, it was observed that 18 (8.9%) patients delayed their treatment/follow-up due to fear of Covid-19 infection. A high HADS anxiety score was observed in 58 (28.7%) patients, and a high HADS depression score was observed in 39 patients (19.3%). Conclusion: Cancer patients are seriously worried about the progression of their cancer due to changes in follow-up or treatment due to Covid-19 pandemic. However, despite the associated risks, they were found to want to continue their treatment as planned.
{"title":"Concerns and expectations of patients with cancer in the Covid-19 pandemic: A prospective cohort study","authors":"A. Onder, Derya Kıvrak Salim, M. Karaca, S. Bayram, Armağan Aydin, Sevil Göktaş, M. Koçer, Deniz ÖZBAY GEDİZ, M. Yıldız, Banu Öztürk","doi":"10.7197/cmj.1210488","DOIUrl":"https://doi.org/10.7197/cmj.1210488","url":null,"abstract":"İntroduction and aim: Cancer affects people psychologically and organically. The emotional state of cancer patients is fragile and can be affected by many factors. We aimed to evaluate the effect of the Covid-19 pandemic on the mood and behavioral changes of cancer patients with solid cancer who are in follow-up and treatment. \u0000Material and Method: A face-to-face questionnaire was filled in solid cancer patients without known psychological disorders who applied to the Medical Oncology outpatient clinic between 1-30 September 2021. The Hospital Anxiety and Depression Scale (HADS) and the scale examining the perspectives on Covid-19 were applied to the patients whose consent was obtained. \u0000Results: A total of 235 people, 139 women and 63 men, participated in the survey. In the review of 202 completed surveys, the median age was 55 (23-83 years). In the study in which seventeen different solid cancer patients were evaluated, breast (52.5%), colon (19.3%) and lung (10.8%) cancers were most common. Most of the people who were more afraid of Covid-19 compared to cancer were patients who were on active cancer treatment. In the multivariate regression analysis, being on active treatment was found to be the only risk factor for 'being more afraid of Covid-19' compared to cancer. During Covid-19 pandemic, it was observed that 18 (8.9%) patients delayed their treatment/follow-up due to fear of Covid-19 infection. A high HADS anxiety score was observed in 58 (28.7%) patients, and a high HADS depression score was observed in 39 patients (19.3%). Conclusion: Cancer patients are seriously worried about the progression of their cancer due to changes in follow-up or treatment due to Covid-19 pandemic. However, despite the associated risks, they were found to want to continue their treatment as planned.","PeriodicalId":10750,"journal":{"name":"Cumhuriyet medical journal","volume":"181 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73743351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Çaylak, D. Atasoy, Nazım Çetinkaya, İsmet Can, Rağıp Sarıismailoğlu, M. Atalar
ABSTRACT Background/aim: Early in the COVID-19 pandemic, chest computerized tomography (CCT) was shown to be more sensitive than real-time reverse transcription polymerase chain Reaction (rRT-PCR) in detecting the disease, especially in regions with high disease prevalence. In this study, we aimed to determine the sensitivity and specificity of chest CT in the diagnosis of COVID-19. Materials and methods: Between 17 March, 2020 and 25 April, 2020, 2170 patients who were admitted to the hospital for any reason and underwent chest CT scanning were retrospectively analyzed. Patients with a pre-diagnosis of COVID-19 and a positive rRT-PCR test, two consecutive negative rRT-PCR tests, or with a first negative rRT-PCR test and a positive follow-up rRT-PCR test were included. The day of the rRT-PCR test for these patients was counted as day “0,” and 200 patients whose CCT was performed within +/- three days were included in the study. Results: Of the 200 patients included in the study, 118 were rRT-PCR-positive, and 82 were rRT-PCR-negative. Of the 118 patients with positive rRT-PCR results, 62/118 (52.5%) had positive CCT scans. With the rRT-PCR results as the reference, the sensitivity, specificity, and accuracy of CCT in indicating COVID-19 infection were 52.5% (95% CI 43–61%), 67% (95% CI 56–77%), and 58.5% (95% CI 51-65%), respectively. The negative predictive value of CCT in diagnosing COVID-19 was greater for women than for men (p = 0.01). Conclusions: In regions where the prevalence of COVID-19 is not high, the use of CCT in the diagnosis of the disease is not an alternative to the rRT-PCR test due to its low sensitivity.
背景/目的:在COVID-19大流行早期，胸部计算机断层扫描(CCT)在检测疾病方面比实时逆转录聚合酶链反应(rRT-PCR)更敏感，特别是在疾病高发地区。在本研究中，我们旨在确定胸部CT诊断COVID-19的敏感性和特异性。材料和方法:回顾性分析2020年3月17日至2020年4月25日期间因任何原因入院并行胸部CT扫描的2170例患者。纳入了预诊断为COVID-19且rRT-PCR检测阳性、连续两次rRT-PCR检测阴性或首次rRT-PCR检测阴性且随访rRT-PCR检测阳性的患者。这些患者进行rRT-PCR检测的当天计算为第0天，在+/- 3天内进行CCT的200例患者被纳入研究。结果:纳入研究的200例患者中，118例rrt - pcr阳性，82例rrt - pcr阴性。在118例rRT-PCR结果阳性的患者中，62/118(52.5%)的CCT扫描呈阳性。以rRT-PCR结果为参照，CCT检测COVID-19感染的敏感性为52.5% (95% CI 43 ~ 61%)，特异性为67% (95% CI 56 ~ 77%)，准确性为58.5% (95% CI 51 ~ 65%)。女性CCT诊断COVID-19的阴性预测值大于男性(p = 0.01)。结论:在COVID-19患病率不高的地区，由于CCT的敏感性较低，不能替代rRT-PCR检测诊断疾病。
{"title":"Can Chest CT be the first-line diagnostic test in COVID-19? A cross-sectional study","authors":"H. Çaylak, D. Atasoy, Nazım Çetinkaya, İsmet Can, Rağıp Sarıismailoğlu, M. Atalar","doi":"10.7197/cmj.1164858","DOIUrl":"https://doi.org/10.7197/cmj.1164858","url":null,"abstract":"ABSTRACT \u0000Background/aim: Early in the COVID-19 pandemic, chest computerized tomography (CCT) was shown to be more sensitive than real-time reverse transcription polymerase chain Reaction (rRT-PCR) in detecting the disease, especially in regions with high disease prevalence. In this study, we aimed to determine the sensitivity and specificity of chest CT in the diagnosis of COVID-19. \u0000Materials and methods: Between 17 March, 2020 and 25 April, 2020, 2170 patients who were admitted to the hospital for any reason and underwent chest CT scanning were retrospectively analyzed. Patients with a pre-diagnosis of COVID-19 and a positive rRT-PCR test, two consecutive negative rRT-PCR tests, or with a first negative rRT-PCR test and a positive follow-up rRT-PCR test were included. The day of the rRT-PCR test for these patients was counted as day “0,” and 200 patients whose CCT was performed within +/- three days were included in the study. \u0000Results: Of the 200 patients included in the study, 118 were rRT-PCR-positive, and 82 were rRT-PCR-negative. Of the 118 patients with positive rRT-PCR results, 62/118 (52.5%) had positive CCT scans. With the rRT-PCR results as the reference, the sensitivity, specificity, and accuracy of CCT in indicating COVID-19 infection were 52.5% (95% CI 43–61%), 67% (95% CI 56–77%), and 58.5% (95% CI 51-65%), respectively. The negative predictive value of CCT in diagnosing COVID-19 was greater for women than for men (p = 0.01). \u0000Conclusions: In regions where the prevalence of COVID-19 is not high, the use of CCT in the diagnosis of the disease is not an alternative to the rRT-PCR test due to its low sensitivity.","PeriodicalId":10750,"journal":{"name":"Cumhuriyet medical journal","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83812090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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