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Associations between genetic variations in oxytocin pathway genes and hippocampal volume: Insights from the UK Biobank 催产素途径基因的遗传变异与海马体积之间的关系:来自英国生物银行的见解。
IF 3.2 2区 心理学 Q1 BEHAVIORAL SCIENCES Pub Date : 2025-02-01 DOI: 10.1016/j.cortex.2024.11.017
Shanshan Xiao , Natalie C. Ebner , Junhua Dang , Gull Rukh , Lars Westberg , Helgi B. Schiöth , Håkan Fischer
The role of oxytocin-related genes in social-cognitive function has been previously established, but structural brain mechanisms underlying this link remain poorly understood. Utilizing a substantial dataset from the UK Biobank (N ≈ 30,000), this research determined associations between variations in ten single nucleotide polymorphisms (SNPs) within three oxytocin pathway genes (i.e., the oxytocin/neurophysin I prepropetide gene, the cluster of differentiation 38 glycoprotein gene, the oxytocin receptor gene) and whole-brain gray matter volume. Carriers of the AA or AG genotypes of the oxytocin receptor gene rs237851 SNP exhibited significantly larger hippocampal volume than carriers of the GG genotype. These results support the link between variations in the oxytocin receptor gene and hippocampal structure, with possible impact on social-cognitive function such as social recognition memory.
催产素相关基因在社会认知功能中的作用已经被确立,但是这种联系背后的大脑结构机制仍然知之甚少。利用来自英国生物银行(N≈30,000)的大量数据集,本研究确定了三个催产素途径基因(即催产素/神经physin I前肽基因,分化38糖蛋白簇基因,催产素受体基因)中十个单核苷酸多态性(snp)变异与全脑灰质体积之间的关系。催产素受体基因rs237851 SNP的AA或AG基因型携带者的海马体积明显大于GG基因型携带者。这些结果支持了催产素受体基因变异与海马体结构之间的联系,并可能影响社会认知功能,如社会识别记忆。
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引用次数: 0
Corrigendum to “Overlapping but separate number representations in the intraparietal sulcus—Probing format- and modality-independence in sighted Braille readers” [Cortex 162 (May 2023) 65–80] “在有视力的盲文读者的顶叶内沟探测格式和模式独立性中重叠但独立的数字表示”的更正[皮质162(五月2023)65-80]。
IF 3.2 2区 心理学 Q1 BEHAVIORAL SCIENCES Pub Date : 2025-02-01 DOI: 10.1016/j.cortex.2024.12.015
Marcin Szwed
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引用次数: 0
A new chapter of Cortex
IF 3.2 2区 心理学 Q1 BEHAVIORAL SCIENCES Pub Date : 2025-02-01 DOI: 10.1016/j.cortex.2025.01.007
Robert D. McIntosh , D. Samuel Schwarzkopf
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引用次数: 0
Semantic and pre-semantic defects of person recognition in semantic dementia. A commentary to the Belliard & Merck's paper: “Is semantic dementia an outdated entity? “
IF 3.2 2区 心理学 Q1 BEHAVIORAL SCIENCES Pub Date : 2025-02-01 DOI: 10.1016/j.cortex.2024.12.013
Guido Gainotti
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引用次数: 0
Cover figure
IF 3.2 2区 心理学 Q1 BEHAVIORAL SCIENCES Pub Date : 2025-02-01 DOI: 10.1016/S0010-9452(25)00034-6
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引用次数: 0
Linking structural and functional changes during healthy aging and semantic dementia using multilayer brain network analysis 利用多层脑网络分析将健康衰老和语义性痴呆期间的结构和功能变化联系起来。
IF 3.2 2区 心理学 Q1 BEHAVIORAL SCIENCES Pub Date : 2025-02-01 DOI: 10.1016/j.cortex.2024.11.013
Gwendolyn Jauny , Marine Le Petit , Shailendra Segobin , Catherine Merck , Serge Belliard , Francis Eustache , Mickael Laisney , Thomas Hinault
Healthy aging is characterized by frontal and diffuse brain changes, while certain age-related pathologies such as semantic dementia will be associated with more focal brain lesions, particularly in the temporo-parietal regions. These changes in structural integrity could influence functional brain networks. Here we use multilayer brain network analysis on structural (DWI) and functional (fMRI) data in younger and older healthy individuals and patients with semantic dementia. Relative to younger adults, results revealed lower levels of similarity of connectivity patterns between brain structure and function, and an increased network clustering in frontal regions in healthy older individuals. These changes were either associated with a preservation (similarity) and a decrease (clustering) in cognitive performance. Patients with semantic dementia showed an increase in the similarity of structural and functional connectivity patterns, as well as an increase in clustering in temporo-parietal regions. These changes were respectively associated with a preservation and a decrease in cognitive performance. These results provide a better characterization of distinct profiles of age- and pathology-brain network changes and their association with the preservation or the decline of cognitive functions.
健康衰老的特征是额叶和弥漫性脑变化,而某些与年龄相关的病理,如语义性痴呆,将与更多的局灶性脑病变相关,特别是在颞顶叶区域。这些结构完整性的变化可能会影响功能性大脑网络。在这里,我们使用多层脑网络分析结构(DWI)和功能(fMRI)数据的年轻和老年健康个体和语义痴呆患者。与年轻人相比,研究结果显示,健康的老年人大脑结构和功能之间的连接模式相似性较低,额叶区域的网络聚集性增加。这些变化要么与认知表现的保持(相似性)有关,要么与认知表现的下降(聚类)有关。语义性痴呆患者表现出结构和功能连接模式相似性的增加,以及颞顶叶区域聚类的增加。这些变化分别与认知能力的保持和下降有关。这些结果更好地描述了年龄和病理大脑网络变化的不同特征,以及它们与认知功能保存或下降的关系。
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引用次数: 0
Following in Luria’s footsteps: The first training booklet for the neuropsychological assessment of patients with brain lesions 跟随Luria的脚步:第一本关于脑损伤患者神经心理学评估的培训手册。
IF 3.2 2区 心理学 Q1 BEHAVIORAL SCIENCES Pub Date : 2025-02-01 DOI: 10.1016/j.cortex.2024.10.006
Marco Catani , Luciano Mecacci
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引用次数: 0
Complex memories induced by intracranial electrical brain stimulation are related to complex networks 脑内电刺激诱发的复杂记忆与复杂网络有关。
IF 3.2 2区 心理学 Q1 BEHAVIORAL SCIENCES Pub Date : 2025-02-01 DOI: 10.1016/j.cortex.2024.11.015
Jonathan Curot , Vincent Dornier , Luc Valton , Marie Denuelle , Alexis Robin , Florence Rulquin , Jean-Christophe Sol , Amaury De Barros , Agnès Trébuchon , Christian Bénar , Fabrice Bartolomei , Emmanuel J. Barbeau
The precise and fleeting moment of rich recollection triggered by an environmental cue is difficult to reproduce in the lab. However, epilepsy patients can experience sudden reminiscences after intracranial electrical brain stimulation (EBS). In these cases, the transient brain state related to the activation of the engram and its conscious perception can be recorded using intracerebral EEG (iEEG).
We collected various EBS-induced reminiscences for iEEG analysis, classifying them as follows: no or weak details (familiarity); moderate details and context (semantic and personal semantic memories); high details and context (episodic). Nine brain areas were selected within the temporal lobes (including the hippocampus and temporal neocortex, ipsi- and contralateral) and the insula, defining a network (each area as a node). Functional connectivity was measured by estimating pair-wise non-linear correlations between signals recorded from these brain regions during different memory events.
Seventeen reminiscences in six patients (2 episodic, 10 personal semantic, 2 semantic memories, 5 familiar objects, 1 déjà-rêvé) were compared to 18 control experiential phenomena (unrelated to reminiscence), 18 negative EBS (which failed to elicit memories or other phenomena) in the same locations, and pre-EBS baseline activity.
The global functional connectivity in the network was higher following EBS-induced reminiscences than during baseline activity, control phenomena, or negative EBS. The degree of connectivity increased with the complexity of memories; it was higher for detailed and contextualized memories like episodic memories. More significant links compared to baseline (edges with higher non-linear correlation relative to baseline) were observed for episodic memories than for less contextualized memories. These increases in connectivity occurred in all frequency bands, except the delta band.
Our results support understanding declarative memory retrieval as having a multiplexed organization. They also show that richer memories activated by intracranial EBS are related to more complex connectivity patterns across medial and neocortical temporal lobe structures.
由环境线索触发的精确而短暂的丰富回忆时刻很难在实验室中重现。然而,癫痫患者在颅内脑电刺激(EBS)后可以经历突然的回忆。在这些情况下,可以使用脑内脑电图(iEEG)记录与印痕激活及其有意识感知相关的短暂大脑状态。我们收集了各种由ebs引起的回忆进行脑电图分析,将其分类如下:没有或弱细节(熟悉);适度的细节和语境(语义记忆和个人语义记忆);高细节和背景(情节)。在颞叶(包括海马和颞叶新皮层,单侧和对侧)和脑岛中选择9个脑区,定义一个网络(每个区域作为一个节点)。功能连通性是通过估计在不同记忆事件中从这些大脑区域记录的信号之间的成对非线性相关性来测量的。将6例患者的17个回忆(2个情景记忆,10个个人语义记忆,2个语义记忆,5个熟悉的物体记忆,1个déjà-rêvé)与18个与回忆无关的对照经验现象,18个相同位置的负性EBS(未能引发记忆或其他现象)和EBS前基线活动进行比较。与基线活动、控制现象或负EBS相比,EBS诱导的回忆后网络中的整体功能连通性更高。连接的程度随着记忆的复杂性而增加;详细和情境化的记忆,如情景记忆,则更高。与基线(相对于基线具有更高非线性相关性的边缘)相比,情景记忆比情境化程度较低的记忆观察到更显著的联系。这些连通性的增加发生在所有频带,除了δ频带。我们的研究结果支持将陈述性记忆检索理解为具有多路复用组织。他们还表明,颅内EBS激活的更丰富的记忆与内侧和新皮层颞叶结构之间更复杂的连接模式有关。
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引用次数: 0
Poststroke action slowing increases with task complexity and is linked to broader brain recruitment
IF 3.2 2区 心理学 Q1 BEHAVIORAL SCIENCES Pub Date : 2025-01-27 DOI: 10.1016/j.cortex.2024.12.024
Olivier Godefroy , Sandrine Canaple , Pierre-Andrea Cervellera , Jeremy Neel , Sophie Tasseel-Ponche , Ardalan Aarabi , Mickael Aubignat , Martine Roussel , GRECogVASC study group
Despite its high prevalence, the mechanisms of slowing in stroke remain surprisingly poorly understood. Our objectives were (1) to determine the profile of slowing as a function of test complexity and (2) to examine the relationship between this complexity effect, test sensitivity and the recruitment of brain areas. The study focused on the 371 stroke patients and 581 controls of the GRECogVASC study assessed with eight time-limited tests: finger tapping, simple reaction time, line cancellation, Trail Making Test parts A and B, coding, and semantic and phonemic fluency tests. Action speed of patients was slower than that of controls (p = .0001); slowing worsened with test complexity (p = .0001) by 7.7% at each step of increasing complexity. The highest test sensitivity was observed (p = .0001) for more complex tests. The number of lesioned voxels associated with action speed increased with test complexity. The sensitivity of the tests roughly paralleled (p = .007) the volume of recruited brain areas. The individual slopes of action duration with test complexity correlated with the volume of lesion (p = .002), white matter hyperintensities (p = .0001) and parenchymal brain fraction (p = .0001). The effect of stroke on slowing is due both to small slowing on simple tests and to a general slowing of processing speed. The test sensitivity reflects the size of recruited brain network and its proportional vulnerability to lesion. In addition to their clinical implications, these results shed light on the organization of the systems that optimize action speed in humans.
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引用次数: 0
Numerical cognition across the lifespan: A selective review of key developmental stages and neural, cognitive, and affective underpinnings
IF 3.2 2区 心理学 Q1 BEHAVIORAL SCIENCES Pub Date : 2025-01-25 DOI: 10.1016/j.cortex.2025.01.005
Mikael Skagenholt , Kenny Skagerlund , Ulf Träff
Numerical cognition constitutes a set of hierarchically related skills and abilities that develop–and may subsequently begin to decline–over developmental time. An innate “number sense” has long been argued to provide a foundation for the development of increasingly complex and applied numerical cognition, such as symbolic numerical reference, arithmetic, and financial literacy. However, evidence for a direct link between basic perceptual mechanisms that allow us to determine numerical magnitude (e.g., “how many” objects are in front of us and whether some of these are of a “greater” or “lesser” quantity), and later symbolic applications for counting and mathematics, has recently been challenged. Understanding how one develops an increasingly precise sense of number and which neurocognitive mechanisms support arithmetic development and achievement is crucial for developing successful mathematics curricula, supporting individual financial literacy and decision-making, and designing appropriate intervention and remediation programs for mathematical learning disabilities as well as mathematics anxiety. The purpose of this review is to provide a broad overview of the cognitive, neural, and affective underpinnings of numerical cognition–spanning the earliest hours of infancy to senior adulthood–and highlight gaps in our knowledge that remain to be addressed.
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Cortex
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