Pub Date : 2023-08-15DOI: 10.2174/2666796704666230815143020
P. Thangaraju, Kunal Verma, Hemasri Velmurugan, Himanshu Nirmal Chanu, T. Chakrabarti, P. Chakrabarti, S. Venkatesan
Coronaviruses have a wide range of health, mobility, and economic consequences. The Coronavirus pandemic is an unprecedented incident that has drawn the attention of the general public to supply chain management. It caused severe interruptions between 2020 and 2022. Despite the importance and size of the impact of coronaviruses on research performance across time, the literature on comprehensive coronavirus-related research performance is limited. This study aimed at a scientometric evaluation of bibliographic facts associated with the supply chain during the pandemic, and data related to it was extracted from PubMed between January 2020 and December 2022. The purpose of this research is to examine scientometric methods such as frequency distribution, percentage analysis, relative growth rate, doubling time, and degree of collaboration. We have obtained a total of 116 publications during this study period, and a maximum of 26 (22.4%) contributions were made in the months of May to August 2021. The relative growth rate is declining, and the doubling time is increasing between May to August 2021. Scientifically analysing and comprehending bibliographic facts associated with the supply chain during the COVID-19 pandemic as widely as possible can also assist society in being better prepared for future pandemic breakouts, ultimately supporting informed decision-making in light of societal values. The authors highly advocate the recent COVID-19 epidemic as a call for greater collaborative, worldwide research.
{"title":"Analysis of Research Publication on Logistics at the Time of COVID-19: A Scientometric Study","authors":"P. Thangaraju, Kunal Verma, Hemasri Velmurugan, Himanshu Nirmal Chanu, T. Chakrabarti, P. Chakrabarti, S. Venkatesan","doi":"10.2174/2666796704666230815143020","DOIUrl":"https://doi.org/10.2174/2666796704666230815143020","url":null,"abstract":"\u0000\u0000Coronaviruses have a wide range of health, mobility, and economic consequences. The Coronavirus pandemic is an unprecedented incident that has drawn the attention of the general public to supply chain management. It caused severe interruptions between 2020 and 2022. Despite the importance and size of the impact of coronaviruses on research performance across time, the literature on comprehensive coronavirus-related research performance is limited. This study aimed at a scientometric evaluation of bibliographic facts associated with the supply chain during the pandemic, and data related to it was extracted from PubMed between January 2020 and December 2022. The purpose of this research is to examine scientometric methods such as frequency distribution, percentage analysis, relative growth rate, doubling time, and degree of collaboration. We have obtained a total of 116 publications during this study period, and a maximum of 26 (22.4%) contributions were made in the months of May to August 2021. The relative growth rate is declining, and the doubling time is increasing between May to August 2021. Scientifically analysing and comprehending bibliographic facts associated with the supply chain during the COVID-19 pandemic as widely as possible can also assist society in being better prepared for future pandemic breakouts, ultimately supporting informed decision-making in light of societal values. The authors highly advocate the recent COVID-19 epidemic as a call for greater collaborative, worldwide research.\u0000","PeriodicalId":10815,"journal":{"name":"Coronaviruses","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80000686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-15DOI: 10.2174/2666796704666230815142955
P. Thangaraju, Hemasri Velmurugan
The worldwide COVID-19 pandemic has resulted in an unprecedented influx of patients in hospitals, raising ethical concerns not just about triage and life-support decisions but also about family visits and the quality of end-of-life care. The value of ethics in the public healthcare system cannot be overstated; nonetheless, the ethics-related problems (or issues) identified during this epidemic have been linked to a lack of accountability, resource allocation challenges, and a loss of trust in healthcare providers. These elements have the ability to shake our ethical ideas, exacerbate ethical dilemmas, and put carers in dangerous situations. To determine the prevalence and distribution of ethical principles in COVID-19-related research publications. The keywords were used to check the articles published on ethics-related problems at the time of the COVID-19 pandemic, published between January 1, 2021, and August 31, 2022. Secondly, we aimed to identify the prevalence and distribution of these ethical principles in research publications related to COVID-19. A total of 6152 articles were identified; 2816 were included for abstract and title screening. Of the 159 articles, 134 were excluded based on the inclusion and exclusion criteria. The remaining 25 articles were scrutinised extensively. There were 17 (68%) literature reviews, 5 (20%) systematic reviews, 1 (4%) integrative review, 1 (4%) cross-sectional study, and 1 (4%) observational study. It is evident from the multitude of papers on the issue that medical ethical challenges, as well as ethical discussions and debates, continue to develop virtually every day. We attempted to portray the COVID-19 whirlpool, encompassing the scope, nature, and urgency of the issues that developed in a highly charged political atmosphere. There have been efforts to use ethical considerations to justify triage procedures. An imbalance between utilitarian and individual ethics, regardless of perspective, leads to insoluble discomforts that carers must overcome.
{"title":"Ethical Challenges at the Time of the Covid-19 Pandemic – A Systematic Review","authors":"P. Thangaraju, Hemasri Velmurugan","doi":"10.2174/2666796704666230815142955","DOIUrl":"https://doi.org/10.2174/2666796704666230815142955","url":null,"abstract":"\u0000\u0000The worldwide COVID-19 pandemic has resulted in an unprecedented influx of patients in hospitals, raising ethical concerns not just about triage and life-support decisions but also about family visits and the quality of end-of-life care. The value of ethics in the public healthcare system cannot be overstated; nonetheless, the ethics-related problems (or issues) identified during this epidemic have been linked to a lack of accountability, resource allocation challenges, and a loss of trust in healthcare providers. These elements have the ability to shake our ethical ideas, exacerbate ethical dilemmas, and put carers in dangerous situations.\u0000\u0000\u0000\u0000To determine the prevalence and distribution of ethical principles in COVID-19-related research publications.\u0000\u0000\u0000\u0000The keywords were used to check the articles published on ethics-related problems at the time of the COVID-19 pandemic, published between January 1, 2021, and August 31, 2022. Secondly, we aimed to identify the prevalence and distribution of these ethical principles in research publications related to COVID-19.\u0000\u0000\u0000\u0000A total of 6152 articles were identified; 2816 were included for abstract and title screening. Of the 159 articles, 134 were excluded based on the inclusion and exclusion criteria. The remaining 25 articles were scrutinised extensively. There were 17 (68%) literature reviews, 5 (20%) systematic reviews, 1 (4%) integrative review, 1 (4%) cross-sectional study, and 1 (4%) observational study.\u0000\u0000\u0000\u0000It is evident from the multitude of papers on the issue that medical ethical challenges, as well as ethical discussions and debates, continue to develop virtually every day. We attempted to portray the COVID-19 whirlpool, encompassing the scope, nature, and urgency of the issues that developed in a highly charged political atmosphere. There have been efforts to use ethical considerations to justify triage procedures. An imbalance between utilitarian and individual ethics, regardless of perspective, leads to insoluble discomforts that carers must overcome.\u0000","PeriodicalId":10815,"journal":{"name":"Coronaviruses","volume":"29 1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78014545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-08DOI: 10.2174/2666796704666230808162930
A. M. de Oliveira, Luana Michelly Aparecida da Costa, G. J. Aguilar, Luiz Ricardo Albano Dos Santos, Wilbert Dener Lemos Costa, Dantony de Castro Barros Donato, Felipe Foresto, V. Bollela
Self-care and self-education are essential for maintaining the health of the population, mainly in the pandemic scenario as established by COVID-19, where social distancing and avoiding agglomeration in closed environments is strongly recommended, as well as preventing the spread of fake news. This study aimed to describe the development and implementation of a self-care and learning application related to COVID-19. In 2020, right at the beginning of the pandemic, a multidisciplinary team at the University of São Paulo -Brazil, was formed to develop a technological platform called Meu Diário de Quarentena® (My Quarantine Diary). In this environment, information on self-care, self-monitoring, and health education was made available to people facing the challenges of the COVID-19 pandemic. The tools, including HTML, CSS, PHP, and MySQL database manager, were used. Meu Diário de Quarentena® (My Quarantine Diary) platform allowed each person to make their own assessment and keep a follow-up of signs and symptoms of COVID-19 through a diary that analyzed the clinical presentation, provided guidance, and suggested an action in real-time to reduce stress and worries. A diagnostic support algorithm was implemented to mitigate false alarms and highlight the importance of caring for family members when an infection was suspected. Furthermore, people were trained with an interactive quiz to promote health education and to offer relevant and updated information related to the pandemic, which contributed to preventing the spread of fake news. A website application (web app) for screening signs and symptoms, self-care, self-monitoring, and promoting health education related to the COVID-19 pandemic was developed and made available on the network. The entire population was given access to Meu Diário de Quarentena® (My Quarantine Diary).
自我保健和自我教育对于维持人口健康至关重要，特别是在COVID-19造成的大流行情况下，强烈建议保持社交距离和避免在封闭环境中聚集，并防止假新闻的传播。本研究旨在描述与COVID-19相关的自我保健和学习应用程序的开发和实施。2020年，就在大流行开始时，巴西圣保罗大学成立了一个多学科团队，开发了一个名为Meu Diário de Quarentena®(我的检疫日记)的技术平台。在这种环境下，面对COVID-19大流行挑战的人们可以获得有关自我保健、自我监测和健康教育的信息。使用的工具包括HTML、CSS、PHP和MySQL数据库管理器。Meu Diário de Quarentena®(我的隔离日记)平台允许每个人进行自己的评估，并通过日记跟踪COVID-19的体征和症状，分析临床表现，提供指导，并实时提出行动建议，以减少压力和担忧。实施了一种诊断支持算法，以减少误报，并强调在怀疑感染时照顾家庭成员的重要性。此外，还对人们进行了互动测验培训，以促进健康教育，并提供与大流行病有关的相关和最新信息，这有助于防止假新闻的传播。开发并上线新冠肺炎疫情体征、症状筛查、自我保健、自我监测、健康教育网站应用程序(web app)。所有人都可以访问Meu Diário de Quarentena®(我的隔离日记)。
{"title":"My Quarantine Diary: a tool for self-care and learning about COVID-19","authors":"A. M. de Oliveira, Luana Michelly Aparecida da Costa, G. J. Aguilar, Luiz Ricardo Albano Dos Santos, Wilbert Dener Lemos Costa, Dantony de Castro Barros Donato, Felipe Foresto, V. Bollela","doi":"10.2174/2666796704666230808162930","DOIUrl":"https://doi.org/10.2174/2666796704666230808162930","url":null,"abstract":"\u0000\u0000Self-care and self-education are essential for maintaining the health of the population, mainly in the pandemic scenario as established by COVID-19, where social distancing and avoiding agglomeration in closed environments is strongly recommended, as well as preventing the spread of fake news.\u0000\u0000\u0000\u0000This study aimed to describe the development and implementation of a self-care and learning application related to COVID-19.\u0000\u0000\u0000\u0000In 2020, right at the beginning of the pandemic, a multidisciplinary team at the University of São Paulo -Brazil, was formed to develop a technological platform called Meu Diário de Quarentena® (My Quarantine Diary). In this environment, information on self-care, self-monitoring, and health education was made available to people facing the challenges of the COVID-19 pandemic. The tools, including HTML, CSS, PHP, and MySQL database manager, were used.\u0000\u0000\u0000\u0000Meu Diário de Quarentena® (My Quarantine Diary) platform allowed each person to make their own assessment and keep a follow-up of signs and symptoms of COVID-19 through a diary that analyzed the clinical presentation, provided guidance, and suggested an action in real-time to reduce stress and worries. A diagnostic support algorithm was implemented to mitigate false alarms and highlight the importance of caring for family members when an infection was suspected. Furthermore, people were trained with an interactive quiz to promote health education and to offer relevant and updated information related to the pandemic, which contributed to preventing the spread of fake news.\u0000\u0000\u0000\u0000A website application (web app) for screening signs and symptoms, self-care, self-monitoring, and promoting health education related to the COVID-19 pandemic was developed and made available on the network. The entire population was given access to Meu Diário de Quarentena® (My Quarantine Diary).\u0000","PeriodicalId":10815,"journal":{"name":"Coronaviruses","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73957545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-04DOI: 10.2174/2666796704666230804103419
Jérôme Sainton
The opinion of the French National Authority for Health (HAS) on July 21st, 2022, concluded that the mechanism of the SARS-Cov-2 vaccine mandate for caregivers and other health professionals should be maintained. Constructed as a syllogism, the opinion states that the benefit-risk balance of a three-dose vaccination schedule to limit transmission is favorable (major premise) and that this balance necessarily determines the mechanism of SARS-Cov-2 vaccine mandate (minor premise) so that it should be maintained (conclusion). Each of these steps is flawed. First, the benefit-risk analysis of a three-dose vaccination schedule is many times distorted: it fails to transpose the relative efficacy of the vaccination in terms of absolute efficacy; it fails to take into account both the particularly poor efficacy of the vaccination against the risk of infection (symptomatic or not) and its decrease, or even negativation, over time, as well as the worsening of the vaccine escape with the latest Omicron sub-lineages; it does not assess the risk associated with the mechanism, particularly with regard to Covid convalescents and pregnant women. Secondly, the inference made from this analysis to the specific mechanism of mandatory vaccination of caregivers is distorted. There is no refocusing on the specific population of caregivers, and the real and concrete benefit of the mechanism itself is not measured. Thirdly, the very construction of the reasoning is distorted. By reducing a medical problem to the calibration of a strictly technical benefit-risk balance, it evades the intrinsic practical and ethical dimensions of the issue.
{"title":"Criticism of the HAS Opinion of July 21st, 2022, on Maintaining of the SARS-Cov-2 Vaccine Mandate for Healthcare Workers","authors":"Jérôme Sainton","doi":"10.2174/2666796704666230804103419","DOIUrl":"https://doi.org/10.2174/2666796704666230804103419","url":null,"abstract":"\u0000\u0000The opinion of the French National Authority for Health (HAS) on July 21st, 2022, concluded that the mechanism of the SARS-Cov-2 vaccine mandate for caregivers and other health professionals should be maintained. \u0000Constructed as a syllogism, the opinion states that the benefit-risk balance of a three-dose vaccination schedule to limit transmission is favorable (major premise) and that this balance necessarily determines the mechanism of SARS-Cov-2 vaccine mandate (minor premise) so that it should be maintained (conclusion). Each of these steps is flawed.\u0000First, the benefit-risk analysis of a three-dose vaccination schedule is many times distorted: it fails to transpose the relative efficacy of the vaccination in terms of absolute efficacy; it fails to take into account both the particularly poor efficacy of the vaccination against the risk of infection (symptomatic or not) and its decrease, or even negativation, over time, as well as the worsening of the vaccine escape with the latest Omicron sub-lineages; it does not assess the risk associated with the mechanism, particularly with regard to Covid convalescents and pregnant women.\u0000Secondly, the inference made from this analysis to the specific mechanism of mandatory vaccination of caregivers is distorted. There is no refocusing on the specific population of caregivers, and the real and concrete benefit of the mechanism itself is not measured.\u0000Thirdly, the very construction of the reasoning is distorted. By reducing a medical problem to the calibration of a strictly technical benefit-risk balance, it evades the intrinsic practical and ethical dimensions of the issue.\u0000","PeriodicalId":10815,"journal":{"name":"Coronaviruses","volume":"31 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91488476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-01DOI: 10.2174/2666796704666230801092541
Neha Dangi, Himanshu Mehendiratta, Shikha Sharma
With the global pandemic, COVID-19, spurred on by the "Severe Acute Respiratory Syndrome Corona Virus-2 (SARS-CoV-2)," India has been greatly impacted. With a rare fungus known as Mucormycosis, the second wave of COVID-19 significantly impacted the Indian population after the initial phase. Mucormycosis is also known as "black fungus" because of the necrosis of infected skin tissue, which causes it to become black. It is caused by Mucoromycetes, members of the Zygomycetes order and the Mucorales class. COVID-19's effects on various comorbid ailments, such as diabetes, heart problems, and immune-compromised states, range from mild to severe to life-threatening. Mucormycosis moulds are more likely to affect patients who have hyperglycemia, ketoacidosis, solid organ or bone marrow transplantation, liver cirrhosis, or neutropenia. To eliminate Mucormycosis, four primary variables must be addressed: early diagnosis, eradication of predisposing factors, prompt antifungal treatment with surgical removal of all diseased tissues, and adjuvant therapies. Here, the present review discusses the clinical aetiology, symptoms, diagnosis, and therapy for black fungus. The study leads to the conclusion that the use of immunosuppressant medication to combat Covid-19 also elevates the possibility of being infected with mucormycotic.
{"title":"Mucormycosis: A serious catastrophe involving COVID-19 patients","authors":"Neha Dangi, Himanshu Mehendiratta, Shikha Sharma","doi":"10.2174/2666796704666230801092541","DOIUrl":"https://doi.org/10.2174/2666796704666230801092541","url":null,"abstract":"\u0000\u0000With the global pandemic, COVID-19, spurred on by the \"Severe Acute Respiratory Syndrome Corona Virus-2 (SARS-CoV-2),\" India has been greatly impacted. With a rare fungus known as Mucormycosis, the second wave of COVID-19 significantly impacted the Indian population after the initial phase. Mucormycosis is also known as \"black fungus\" because of the necrosis of infected skin tissue, which causes it to become black. It is caused by Mucoromycetes, members of the Zygomycetes order and the Mucorales class. COVID-19's effects on various comorbid ailments, such as diabetes, heart problems, and immune-compromised states, range from mild to severe to life-threatening. Mucormycosis moulds are more likely to affect patients who have hyperglycemia, ketoacidosis, solid organ or bone marrow transplantation, liver cirrhosis, or neutropenia. To eliminate Mucormycosis, four primary variables must be addressed: early diagnosis, eradication of predisposing factors, prompt antifungal treatment with surgical removal of all diseased tissues, and adjuvant therapies. Here, the present review discusses the clinical aetiology, symptoms, diagnosis, and therapy for black fungus. The study leads to the conclusion that the use of immunosuppressant medication to combat Covid-19 also elevates the possibility of being infected with mucormycotic.\u0000","PeriodicalId":10815,"journal":{"name":"Coronaviruses","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87659883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-26DOI: 10.2174/2666796704666230726122536
P. Srivastava, Wayez Naqvi, Prekshi Garg
Coronavirus disease (COVID-19) was an infectious illness brought on by the SARS-CoV-2 virus. The first known SARS-CoV-2 infection was detected in the Wuhan District of China. The diagnostic and therapeutic management of COVID-19 requires an immediate response, as an alternative, quicker in-silico techniques can be used, which can serve as a filter before wet lab validation. A pharmaceutical drug, also known as a medication or medicine, is a chemical substance that is used to treat, cure, prevent, or diagnose a disease or to promote overall health. When a particular class of drugs is used to treat a diseased gene, it can also affect the various healthy non-diseased genes in the body, resulting in altered gene expression and gene function. The adverse effects of medications prescribed to COVID-19 patients form the basis of this study, which genes were being targeted, and what disorders or traits were caused as a result of this activity. COVID-19 is said to cause inflammation of the brain's tissues; inflammation of brain tissue is also a risk factor for Alzheimer's disease. The SARS-CoV-2 infection activates the inflammasome pathway, which is seen in patients with neurodegenerative diseases such as Alzheimer's and Parkinson's. SARS-CoV-2 can enter the brain via the olfactory system or can be transferred through infected immune cells. The virus could enter the body by infecting endothelial cells of the brain. The presence of ACE2 receptors, SARS-CoV-2 receptors, interleukin (IL)-6, IL-1b, tumour necrosis factor (TNF), and IL-17 disrupts the Blood Brain Barrier, allowing the virus to enter the brain.
{"title":"Impact of Prolonged use of COVID-19 Drugs on the Human Neurological System using Insilco Drug-gene Interaction","authors":"P. Srivastava, Wayez Naqvi, Prekshi Garg","doi":"10.2174/2666796704666230726122536","DOIUrl":"https://doi.org/10.2174/2666796704666230726122536","url":null,"abstract":"\u0000\u0000Coronavirus disease (COVID-19) was an infectious illness brought on by the SARS-CoV-2 virus. The first known SARS-CoV-2 infection was detected in the Wuhan District of China. The diagnostic and therapeutic management of COVID-19 requires an immediate response, as an alternative, quicker in-silico techniques can be used, which can serve as a filter before wet lab validation.\u0000\u0000\u0000\u0000A pharmaceutical drug, also known as a medication or medicine, is a chemical substance that is used to treat, cure, prevent, or diagnose a disease or to promote overall health. When a particular class of drugs is used to treat a diseased gene, it can also affect the various healthy non-diseased genes in the body, resulting in altered gene expression and gene function.\u0000\u0000\u0000\u0000The adverse effects of medications prescribed to COVID-19 patients form the basis of this study, which genes were being targeted, and what disorders or traits were caused as a result of this activity.\u0000\u0000\u0000\u0000COVID-19 is said to cause inflammation of the brain's tissues; inflammation of brain tissue is also a risk factor for Alzheimer's disease. The SARS-CoV-2 infection activates the inflammasome pathway, which is seen in patients with neurodegenerative diseases such as Alzheimer's and Parkinson's.\u0000\u0000\u0000\u0000SARS-CoV-2 can enter the brain via the olfactory system or can be transferred through infected immune cells. The virus could enter the body by infecting endothelial cells of the brain. The presence of ACE2 receptors, SARS-CoV-2 receptors, interleukin (IL)-6, IL-1b, tumour necrosis factor (TNF), and IL-17 disrupts the Blood Brain Barrier, allowing the virus to enter the brain.\u0000","PeriodicalId":10815,"journal":{"name":"Coronaviruses","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91059305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-24DOI: 10.2174/2666796704666230724162816
Arbind Kumar, S. Kumar, S Kumar, L. Pal, Sahdev Choudhary
The global incidence of SARS-CoV-2 infection is now very low. Despite the vaccination drive worldwide, the emergence of new omicron variants and their infection have been reported in a few countries. It is now required to identify potential risks associated with the COVID-19 disease aftermath’s 3rd disease wave. During pandemic stages, the healthcare system bears a significant burden in identifying early risk and providing early management to reduce infection. In this investigation, an attempt has been made to assess the laboratory risk of SARS-CoV-2 contamination. The samples were collected from the various blocks of the testing centre, including the surface, floor, diagnostic instruments, solutions, and tap water, and then RNA was isolated and in-vitro diagnostic RT-qPCR was performed. A total of 316 samples were collected and analysed for the presence of SARS-CoV-2 RNA. Our findings confirmed that only four samples (1.77%) had ORF-1ab and E gene signals, which indicated the presence of SARS-CoV-2 RNA. The CT values for the E gene were 34.52 [IQR: 32.37-36.36] and 35.02 [IQR:34.25-35.76] for the ORF1-ab gene, respectively. All four were taken from the surfaces, indicating that other parts were contamination-free. Very few positive contaminations demonstrated that laboratory sterilising processes are fully functional and effective. This study eventually provided more information about the presence of SARS-CoV-2 RNA traces in the environment aftermath of 3rd disease wave of COVID-19, including diagnostic laboratories.
{"title":"Assessment Of Traces Of Sars-Cov-2 Rna In A Laboratory Setting Using In Vitro-Diagnostic Rt-Qpcr","authors":"Arbind Kumar, S. Kumar, S Kumar, L. Pal, Sahdev Choudhary","doi":"10.2174/2666796704666230724162816","DOIUrl":"https://doi.org/10.2174/2666796704666230724162816","url":null,"abstract":"\u0000\u0000The global incidence of SARS-CoV-2 infection is now very low. Despite the vaccination drive worldwide, the emergence of new omicron variants and their infection have been reported in a few countries. It is now required to identify potential risks associated with the COVID-19 disease aftermath’s 3rd disease wave. During pandemic stages, the healthcare system bears a significant burden in identifying early risk and providing early management to reduce infection.\u0000\u0000\u0000\u0000In this investigation, an attempt has been made to assess the laboratory risk of SARS-CoV-2 contamination. The samples were collected from the various blocks of the testing centre, including the surface, floor, diagnostic instruments, solutions, and tap water, and then RNA was isolated and in-vitro diagnostic RT-qPCR was performed. A total of 316 samples were collected and analysed for the presence of SARS-CoV-2 RNA. Our findings confirmed that only four samples (1.77%) had ORF-1ab and E gene signals, which indicated the presence of SARS-CoV-2 RNA. The CT values for the E gene were 34.52 [IQR: 32.37-36.36] and 35.02 [IQR:34.25-35.76] for the ORF1-ab gene, respectively.\u0000\u0000\u0000\u0000All four were taken from the surfaces, indicating that other parts were contamination-free. Very few positive contaminations demonstrated that laboratory sterilising processes are fully functional and effective.\u0000\u0000\u0000\u0000This study eventually provided more information about the presence of SARS-CoV-2 RNA traces in the environment aftermath of 3rd disease wave of COVID-19, including diagnostic laboratories.\u0000","PeriodicalId":10815,"journal":{"name":"Coronaviruses","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91359043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-07DOI: 10.2174/2666796704666230707154746
A. Boretti
This letter aims to explain the observed difference between COVID-19 fatalities in Europe or America, and Africa. At present (January 23, 2023) the cumulative number of COVID-19 fatalities per million people has been 3,080 in South America, 2,709 in Europe, and 2,608 in North America. In particular, the United States and the United Kingdom had 3,265 and 3,203 respectively. With much fewer opportunities to practice social distancing, or hygiene, and much more limited access to health care, Africa only had 180 fatalities per million. The much better performances of Africa have been ascribed to the positive effects of reduced hygiene, increased biome diversity, lack of masking mandates and restrictions, better access to antivirals, a younger population, and lower vaccination rates, which all may have contributed to the much better performances of Africa compared to Europe and North America against COVID-19.
{"title":"Explaining why Africa had much lower COVID-19 fatalities per million than Europe and North America","authors":"A. Boretti","doi":"10.2174/2666796704666230707154746","DOIUrl":"https://doi.org/10.2174/2666796704666230707154746","url":null,"abstract":"\u0000\u0000This letter aims to explain the observed difference between COVID-19 fatalities in Europe or America, and Africa. At present (January 23, 2023) the cumulative number of COVID-19 fatalities per million people has been 3,080 in South America, 2,709 in Europe, and 2,608 in North America. In particular, the United States and the United Kingdom had 3,265 and 3,203 respectively. With much fewer opportunities to practice social distancing, or hygiene, and much more limited access to health care, Africa only had 180 fatalities per million. The much better performances of Africa have been ascribed to the positive effects of reduced hygiene, increased biome diversity, lack of masking mandates and restrictions, better access to antivirals, a younger population, and lower vaccination rates, which all may have contributed to the much better performances of Africa compared to Europe and North America against COVID-19.\u0000","PeriodicalId":10815,"journal":{"name":"Coronaviruses","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91193793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-23DOI: 10.2174/2666796704666230623150612
Amit Sharma, Manisha Vohra, Mohammad Amir, Ian Osoro
This case report presents a case of a 51-year-old male patient who was found to be diabetic after recovering from COVID-19. The patient was admitted to the COVID care center after testing positive for COVID-19 on November 2020. After spending one week in intensive care and ten days in the isolation ward of the COVID care center, he continued to feel multiple side effects. After fifteen days, he began showing signs of recovery and had no fever or other symptoms of COVID-19. The third SARS-Cov-2 RNA by RT-PCR sample test was also found to be negative. He was shifted to a non-COVID hospital when he became stable. For COVID-19, he was treated with supplementary oxygen therapy by keeping his oxygen level at 5L/min with titrating flow rate SpO2 of more than 90%. The hydroxychloroquine 400 mg orally BD for two days, followed by 200 mg orally BD for four days with a combination of azithromycin 500mg orally OD for five days, was prescribed to him to treat COVID-19. According to the report "New-onset diabetes in COVID-19," published in the New England Journal of Medicine, there is a bidirectional relationship between COVID-19 and diabetes.
{"title":"A Case Report on Covid-19 Causing New Onset of Diabetes Even with No History","authors":"Amit Sharma, Manisha Vohra, Mohammad Amir, Ian Osoro","doi":"10.2174/2666796704666230623150612","DOIUrl":"https://doi.org/10.2174/2666796704666230623150612","url":null,"abstract":"\u0000\u0000This case report presents a case of a 51-year-old male patient who was found to be diabetic after recovering from COVID-19.\u0000\u0000\u0000\u0000The patient was admitted to the COVID care center after testing positive for COVID-19 on November 2020. After spending one week in intensive care and ten days in the isolation ward of the COVID care center, he continued to feel multiple side effects. After fifteen days, he began showing signs of recovery and had no fever or other symptoms of COVID-19. The third SARS-Cov-2 RNA by RT-PCR sample test was also found to be negative. He was shifted to a non-COVID hospital when he became stable. For COVID-19, he was treated with supplementary oxygen therapy by keeping his oxygen level at 5L/min with titrating flow rate SpO2 of more than 90%. The hydroxychloroquine 400 mg orally BD for two days, followed by 200 mg orally BD for four days with a combination of azithromycin 500mg orally OD for five days, was prescribed to him to treat COVID-19.\u0000\u0000\u0000\u0000According to the report \"New-onset diabetes in COVID-19,\" published in the New England Journal of Medicine, there is a bidirectional relationship between COVID-19 and diabetes.\u0000","PeriodicalId":10815,"journal":{"name":"Coronaviruses","volume":"61 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74348005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-08DOI: 10.2174/2666796704666230608121558
Badruddeen, Mohd Zafar Khan, M. Khushtar, J. Akhtar, Mohammad Irfan Khan, Mohammad Ahmad, Ishana Chand
The world is confronted with the threat of a pandemic driven by a novel coronavirus, namely Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The disease was spread in December 2019 in Wuhan (China). The virus has spread to 216 nations, regions, and territories around the world. There were around 510306 confirmed cases and 333401 deaths by May 2020. Patients with cardiovascular diseases and other co-morbidities were at a high risk of SARS-CoV2 infection that ultimately resulted in the death of the patient. This review highlights the impact of COVID-19 on cardiovascular diseases and other co-morbidities. This review was completed using different sources of search sites like Google Scholar, PubMed, ScienceDirect, Scopus, etc. The diseases associated with the cardiovascular system include myocarditis, heart failure, cardiac injury, and microangiopathy. The mechanisms that cause cardiovascular problems in COVID-19 are myocardial injury pathways, systemic inflammation, altered myocardial demand and supply ratios, plaque rupture, coronary thrombosis, adverse effects of various therapies, and electrolyte imbalances. Several studies provide an important clinical and molecular clue to cardiac involvement during COVID-19. The high cytokine concentrations may contribute to myocardial lesions and a poor disease prognosis. In an earlier study, autopsy reports of COVID-19 found the SARS-CoV-2 genome in myocardial tissues. This also demonstrates that cytokine-induced organ dysfunction contributes to the disease process. This review concludes that the impact of coronavirus on the cardiac system has shown a harmful effect, and patients with co-morbidities are likely to be more affected by COVID-19 infection.
{"title":"A systematic review of covid-19 impact on cardiovascular diseases","authors":"Badruddeen, Mohd Zafar Khan, M. Khushtar, J. Akhtar, Mohammad Irfan Khan, Mohammad Ahmad, Ishana Chand","doi":"10.2174/2666796704666230608121558","DOIUrl":"https://doi.org/10.2174/2666796704666230608121558","url":null,"abstract":"\u0000\u0000The world is confronted with the threat of a pandemic driven by a novel coronavirus, namely Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The disease was spread in December 2019 in Wuhan (China). The virus has spread to 216 nations, regions, and territories around the world. There were around 510306 confirmed cases and 333401 deaths by May 2020. Patients with cardiovascular diseases and other co-morbidities were at a high risk of SARS-CoV2 infection that ultimately resulted in the death of the patient.\u0000\u0000\u0000\u0000This review highlights the impact of COVID-19 on cardiovascular diseases and other co-morbidities.\u0000\u0000\u0000\u0000This review was completed using different sources of search sites like Google Scholar, PubMed, ScienceDirect, Scopus, etc.\u0000\u0000\u0000\u0000The diseases associated with the cardiovascular system include myocarditis, heart failure, cardiac injury, and microangiopathy. The mechanisms that cause cardiovascular problems in COVID-19 are myocardial injury pathways, systemic inflammation, altered myocardial demand and supply ratios, plaque rupture, coronary thrombosis, adverse effects of various therapies, and electrolyte imbalances. Several studies provide an important clinical and molecular clue to cardiac involvement during COVID-19. The high cytokine concentrations may contribute to myocardial lesions and a poor disease prognosis. In an earlier study, autopsy reports of COVID-19 found the SARS-CoV-2 genome in myocardial tissues. This also demonstrates that cytokine-induced organ dysfunction contributes to the disease process.\u0000\u0000\u0000\u0000This review concludes that the impact of coronavirus on the cardiac system has shown a harmful effect, and patients with co-morbidities are likely to be more affected by COVID-19 infection.\u0000","PeriodicalId":10815,"journal":{"name":"Coronaviruses","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74049384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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