Pub Date : 2023-05-10DOI: 10.2174/1573413719666230510102306
Yurong Liu, Xiaolong Zeng, Lin Zhu, Cong Wang, K. Geng, Ruohe Yao
The development of high-performance piezoelectric pressure sensors with outstanding sensitivity, good linearity, flexibility, durability, and biocompatibility is of great significance for smart robotics, human healthcare devices, smart sensors, and electronic skin. Thus, considerable progress has been achieved in enhancing the piezoelectric property of PVDF-TrFE-based composite pressure sensors by adding various ZnO nanostructures in PVDF-TrFE polymer acting as a nucleating agent and dielectric material. In this work, flexible pressure sensors with a sandwich structure based on PVDF-TrFE/nano-ZnO composite sensing film were fabricated using a simple spin-coating method and post-annealing process, while electrospinning and high-voltage polarization processes were not adopted. Poly (vinylidene fluoride-trifluoroethylene) (PVDF-TrFE)/nano-ZnO composite films were prepared via spin coating to fabricate flexible piezoelectric pressure sensors. ZnO nanoparticles (ZnO NPs), tetrapod ZnO (T-ZnO) and ZnO nanorods (ZnO NRs) were used as nano-fillers for piezoelectric PVDF-TrFE, to enhance the beta-crystal ratio as well as the crystallinity of PVDF-TrFE. The structural and surface morphologies of the composite films were investigated using Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and scanning electron microscopy (SEM). Among three different types of ZnO nanostructures with a concentration range (0-7.5 wt%), the sensor with 0.75 wt% ZnO NRs nanofiller exhibits a maximum output voltage of 1.73 V under an external pressure of 3 N and a maximum sensitivity of 586.3 mV/N at the range of 0-3 N. Further, the sensor can generate a clear piezoelectric voltage under bending and twisting deformation as well as compression and tensile deformation. To summarize, the addition of different concentrations of nano-ZnO can remarkably improve the piezoelectric performance of the composite sensor, and ZnO NRs can achieve better piezoelectric properties of the sensor as compared to ZnO NPs and T-ZnO. In addition, the sensor with 0.75 wt% ZnO NRs as nanofiller has the highest piezoelectric response, which is about 2.4 times that of the pure PVDF-TrFE sensor. It is demonstrated that the sensor has great potential applications in wearable health monitoring systems and mechanical stress measurement electronics.
{"title":"Effect of Nanostructure Morphology and Concentration on the Piezoelectric Performance of Flexible Pressure Sensor Based on PVDF-TrFE/Nano-ZnO Composite Thin Film","authors":"Yurong Liu, Xiaolong Zeng, Lin Zhu, Cong Wang, K. Geng, Ruohe Yao","doi":"10.2174/1573413719666230510102306","DOIUrl":"https://doi.org/10.2174/1573413719666230510102306","url":null,"abstract":"\u0000\u0000The development of high-performance piezoelectric pressure sensors with outstanding sensitivity, good linearity, flexibility, durability, and biocompatibility is of great significance for smart robotics, human healthcare devices, smart sensors, and electronic skin. Thus, considerable progress has been achieved in enhancing the piezoelectric property of PVDF-TrFE-based composite pressure sensors by adding various ZnO nanostructures in PVDF-TrFE polymer acting as a nucleating agent and dielectric material. In this work, flexible pressure sensors with a sandwich structure based on PVDF-TrFE/nano-ZnO composite sensing film were fabricated using a simple spin-coating method and post-annealing process, while electrospinning and high-voltage polarization processes were not adopted.\u0000\u0000\u0000\u0000Poly (vinylidene fluoride-trifluoroethylene) (PVDF-TrFE)/nano-ZnO composite films were prepared via spin coating to fabricate flexible piezoelectric pressure sensors. ZnO nanoparticles (ZnO NPs), tetrapod ZnO (T-ZnO) and ZnO nanorods (ZnO NRs) were used as nano-fillers for piezoelectric PVDF-TrFE, to enhance the beta-crystal ratio as well as the crystallinity of PVDF-TrFE. The structural and surface morphologies of the composite films were investigated using Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and scanning electron microscopy (SEM).\u0000\u0000\u0000\u0000Among three different types of ZnO nanostructures with a concentration range (0-7.5 wt%), the sensor with 0.75 wt% ZnO NRs nanofiller exhibits a maximum output voltage of 1.73 V under an external pressure of 3 N and a maximum sensitivity of 586.3 mV/N at the range of 0-3 N. Further, the sensor can generate a clear piezoelectric voltage under bending and twisting deformation as well as compression and tensile deformation.\u0000\u0000\u0000\u0000To summarize, the addition of different concentrations of nano-ZnO can remarkably improve the piezoelectric performance of the composite sensor, and ZnO NRs can achieve better piezoelectric properties of the sensor as compared to ZnO NPs and T-ZnO. In addition, the sensor with 0.75 wt% ZnO NRs as nanofiller has the highest piezoelectric response, which is about 2.4 times that of the pure PVDF-TrFE sensor. It is demonstrated that the sensor has great potential applications in wearable health monitoring systems and mechanical stress measurement electronics.\u0000","PeriodicalId":10827,"journal":{"name":"Current Nanoscience","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2023-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47937317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-03DOI: 10.2174/1573413719666230503144904
Pawan Gupta, Amit K. Mittal, Kritigya Mishra, Neha Handa, M. Paul
Nanomaterial-based therapeutics is an emerging tool for the treatment of numerous types of cancer. Various types of polymeric, lipid and inorganic nanoparticles (NPs) result in a wider series of applications in cancer diagnosis and therapeutics. The NPs properties are due to high surface area to volume ratio, surface plasmon resonance, absorption in the visible spectrum and light scattering. These unique characteristics of NPs arise due to their optical surface properties for conjugation/surface modification and smaller size. In cancer therapeutics, NPs based products are used as a biomarker for early detection/diagnosis of tumours, drug nano-conjugates for the delivery of chemotherapeutic drugs to the tumour-specific site, chemo-protective agents, etc. Furthermore, other advantages of NPs are biocompatibility, lesser toxicity, enhanced permeability and retention effect, higher stability, and specific targeting with a selective accumulation of nano drugs in the tissue of the tumour. The selective targeting of NPs to tumour tissue is possible by adding surface-active targeting agents i.e., antibodies. The selective transport of drug NPs conjugates to the cancer cells is increased and extravagated due to permeable vasculature from endothelial cells gap while failing the transport of drug NPs conjugates in normal cells. This review emphasizes metallic NPs, including silver NPs (AgNPs) and gold NPs (AuNPs), which are extensively reconnoitered in various applications in cellular targeting, imaging, drug delivery, DNA-NPs conjugates for biosensor/point of care devices development, photothermal/photodynamic therapy, protein-protein interaction, etc. In addition, this review discussed different synthetic methods of AgNPs and AuNPs and characterization methods. Furthermore, it highlighted the different properties and applications of AgNPs and AuNPs in cancer theranostics.
{"title":"Current Expansion of Silver and Gold Nanomaterials towards Cancer Theranostics: Development of Therapeutics","authors":"Pawan Gupta, Amit K. Mittal, Kritigya Mishra, Neha Handa, M. Paul","doi":"10.2174/1573413719666230503144904","DOIUrl":"https://doi.org/10.2174/1573413719666230503144904","url":null,"abstract":"\u0000\u0000Nanomaterial-based therapeutics is an emerging tool for the treatment of numerous types of cancer. Various types of polymeric, lipid and inorganic nanoparticles (NPs) result in a wider series of applications in cancer diagnosis and therapeutics. The NPs properties are due to high surface area to volume ratio, surface plasmon resonance, absorption in the visible spectrum and light scattering. These unique characteristics of NPs arise due to their optical surface properties for conjugation/surface modification and smaller size. In cancer therapeutics, NPs based products are used as a biomarker for early detection/diagnosis of tumours, drug nano-conjugates for the delivery of chemotherapeutic drugs to the tumour-specific site, chemo-protective agents, etc.\u0000Furthermore, other advantages of NPs are biocompatibility, lesser toxicity, enhanced permeability and retention effect, higher stability, and specific targeting with a selective accumulation of nano drugs in the tissue of the tumour. The selective targeting of NPs to tumour tissue is possible by adding surface-active targeting agents i.e., antibodies. The selective transport of drug NPs conjugates to the cancer cells is increased and extravagated due to permeable vasculature from endothelial cells gap while failing the transport of drug NPs conjugates in normal cells. This review emphasizes metallic NPs, including silver NPs (AgNPs) and gold NPs (AuNPs), which are extensively reconnoitered in various applications in cellular targeting, imaging, drug delivery, DNA-NPs conjugates for biosensor/point of care devices development, photothermal/photodynamic therapy, protein-protein interaction, etc. In addition, this review discussed different synthetic methods of AgNPs and AuNPs and characterization methods. Furthermore, it highlighted the different properties and applications of AgNPs and AuNPs in cancer theranostics.\u0000","PeriodicalId":10827,"journal":{"name":"Current Nanoscience","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2023-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46526765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-02DOI: 10.2174/1573413719666230502114208
Marzieh Badiei, Masita Mohammad, Nur Athirah Binti Abdullah, Nilofar Asim, Zahira Yaakob, Mohd Amir Radli Othman
BACKGROUND: Nanocrystalline cellulose (NCC) is one of the most suitable cellulose derivatives for the treatment of wastewater. Various agricultural wastes have been used for the extraction of NCC. Coconut wastes have been widely studied as potential adsorbents for the removal of pollutants, including dyes and heavy metals. METHODS: In this work, nanocrystalline cellulose (NCC) was successfully isolated from coconut husk fibers through alkaline pretreatment accompanied by sulfuric acid hydrolysis. Then, the ability of NCC to adsorb Cu2+ from aqueous solution in batch studies was investigated. RESULTS: Results indicated that the optimal hydrolysis parameters were achieved at 50° C for 45 min with 64% sulfuric acid to extract NCC as rod-like particles with diameters between 4-10 nm. The potential of NCC as a biosorbent to remove copper ions (Cu2+) from aqueous solution was investigated in terms of batch mode and maximum adsorption capacity (qm) of 79.491 mg/g of Cu2+. The adsorption efficiency of Cu2+ions increased with an increase in the adsorbent dosage, decreased with an increase in the initial concentration of contaminant, and increased with the contact time. Under optimal conditions, adsorption kinetic followed a pseudo-second-order kinetic model and the adsorption isotherm fitted most closely with the Langmuir model. CONCLUSION: According to a literature review, NCC from coconut husk fibers has not been used for the adsorption of heavy metals, mainly copper ions. This study shows that NCC from coconut husk fibers can be used as a low-cost and environmentally friendly adsorbent for the removal of Cu2+ from aqueous solutions.
{"title":"Monocomponent biosorption of copper ions (II) onto nanocrystalline cellulose from coconut husk fibers","authors":"Marzieh Badiei, Masita Mohammad, Nur Athirah Binti Abdullah, Nilofar Asim, Zahira Yaakob, Mohd Amir Radli Othman","doi":"10.2174/1573413719666230502114208","DOIUrl":"https://doi.org/10.2174/1573413719666230502114208","url":null,"abstract":"BACKGROUND: Nanocrystalline cellulose (NCC) is one of the most suitable cellulose derivatives for the treatment of wastewater. Various agricultural wastes have been used for the extraction of NCC. Coconut wastes have been widely studied as potential adsorbents for the removal of pollutants, including dyes and heavy metals. METHODS: In this work, nanocrystalline cellulose (NCC) was successfully isolated from coconut husk fibers through alkaline pretreatment accompanied by sulfuric acid hydrolysis. Then, the ability of NCC to adsorb Cu2+ from aqueous solution in batch studies was investigated. RESULTS: Results indicated that the optimal hydrolysis parameters were achieved at 50° C for 45 min with 64% sulfuric acid to extract NCC as rod-like particles with diameters between 4-10 nm. The potential of NCC as a biosorbent to remove copper ions (Cu2+) from aqueous solution was investigated in terms of batch mode and maximum adsorption capacity (qm) of 79.491 mg/g of Cu2+. The adsorption efficiency of Cu2+ions increased with an increase in the adsorbent dosage, decreased with an increase in the initial concentration of contaminant, and increased with the contact time. Under optimal conditions, adsorption kinetic followed a pseudo-second-order kinetic model and the adsorption isotherm fitted most closely with the Langmuir model. CONCLUSION: According to a literature review, NCC from coconut husk fibers has not been used for the adsorption of heavy metals, mainly copper ions. This study shows that NCC from coconut husk fibers can be used as a low-cost and environmentally friendly adsorbent for the removal of Cu2+ from aqueous solutions.","PeriodicalId":10827,"journal":{"name":"Current Nanoscience","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135269376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-18DOI: 10.2174/1573413719666230418100828
Jing Kong, M. Shen, Zheng Ju, Jing Xu, Jing-Xuan Zhang
The aim of this study is to explore and evaluate the possibility of rambutan-shaped micro-nanostructured γ-Al2O3 material’s usage as an adsorbent in industrial wastewater processing. Every year, more than 7 million tons of dyestuff-containing wastewater are produced in the industry. Although there are many adsorbents like fly ash and clays, the shortages limit their actual applications. It is still necessary to find a new cheaper adsorbent. The paper aimed to investigate the adsorption capacity and decolorization ability of rambutan-shaped γ-Al2O3 material synthesized via a composite soft template method. The rambutan-shaped γ-Al2O3 material was prepared and characterized via XRD, TEM, FE-SEM, and FT-IR (See our group’s published article in “Ming Shen*, et al., Acta Phys.-Chim. Sin. 2013, 29 (10), 2286-2294”). The methyl orange aqueous solution was selected as the model of industrial wastewater. The methyl orange solution (15.0 mg·L-1 ) with different pH (2~9) was exposed to a series of amounts of γ-Al2O3 powder ranging from 10.0 to 70.0 mg. Different concentrations of methyl orange solution, ranging from 5.0 to 200.0 mg·L-1 were also tested with the same amount of γAl2O3 powder (50.0 mg). The adsorption-calcination cycle analysis was performed with methyl orange solution (50.0 mg·L-1 ) and 500.0 mg of γ-Al2O3 powder at pH=3. The γ-Al2O3 material exhibits excellent adsorption capacity (114.10 mg·g-1 ) towards acidic methyl orange aqueous solution. At the same time, the decolorization rate of the γ-Al2O3 material reaches about 88%. This material still keeps a 50% decolorization rate after 6 repeats of the adsorption-calcination cycle. Moreover, the excellent self-sedimentation ability of this material also provides an easy separation for future industrial applications. The γ-Al2O3 material with rambutan-like micro-nanostructure presents excellent adsorption capacity/decolorization ability and self-sedimentation ability. It can be used as a new type of adsorbent for wastewater processing. The rambutan-shaped micro-nanostructure plays an important role in maintaining the adsorption ability of the γ-Al2O3 material.
{"title":"Evaluation of the adsorptive performance of rambutan-shaped γ-Al2O3 micro-nanostructure against wastewater containing the azo dye: methyl orange","authors":"Jing Kong, M. Shen, Zheng Ju, Jing Xu, Jing-Xuan Zhang","doi":"10.2174/1573413719666230418100828","DOIUrl":"https://doi.org/10.2174/1573413719666230418100828","url":null,"abstract":"\u0000\u0000The aim of this study is to explore and evaluate the possibility of rambutan-shaped\u0000micro-nanostructured γ-Al2O3 material’s usage as an adsorbent in industrial wastewater processing.\u0000\u0000\u0000\u0000Every year, more than 7 million tons of dyestuff-containing wastewater are produced\u0000in the industry. Although there are many adsorbents like fly ash and clays, the shortages limit their\u0000actual applications. It is still necessary to find a new cheaper adsorbent.\u0000\u0000\u0000\u0000The paper aimed to investigate the adsorption capacity and decolorization ability of rambutan-shaped γ-Al2O3 material synthesized via a composite soft template method.\u0000\u0000\u0000\u0000The rambutan-shaped γ-Al2O3 material was prepared and characterized via XRD, TEM,\u0000FE-SEM, and FT-IR (See our group’s published article in “Ming Shen*, et al., Acta Phys.-Chim. Sin.\u00002013, 29 (10), 2286-2294”). The methyl orange aqueous solution was selected as the model of industrial wastewater. The methyl orange solution (15.0 mg·L-1\u0000) with different pH (2~9) was exposed to a\u0000series of amounts of γ-Al2O3 powder ranging from 10.0 to 70.0 mg. Different concentrations of methyl orange solution, ranging from 5.0 to 200.0 mg·L-1 were also tested with the same amount of γAl2O3 powder (50.0 mg). The adsorption-calcination cycle analysis was performed with methyl orange solution (50.0 mg·L-1\u0000) and 500.0 mg of γ-Al2O3 powder at pH=3.\u0000\u0000\u0000\u0000The γ-Al2O3 material exhibits excellent adsorption capacity (114.10 mg·g-1\u0000) towards acidic\u0000methyl orange aqueous solution. At the same time, the decolorization rate of the γ-Al2O3 material\u0000reaches about 88%. This material still keeps a 50% decolorization rate after 6 repeats of the adsorption-calcination cycle. Moreover, the excellent self-sedimentation ability of this material also provides an easy separation for future industrial applications.\u0000\u0000\u0000\u0000The γ-Al2O3 material with rambutan-like micro-nanostructure presents excellent adsorption capacity/decolorization ability and self-sedimentation ability. It can be used as a new type\u0000of adsorbent for wastewater processing. The rambutan-shaped micro-nanostructure plays an important role in maintaining the adsorption ability of the γ-Al2O3 material.\u0000","PeriodicalId":10827,"journal":{"name":"Current Nanoscience","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2023-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41737075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The regulatory effects of carbon nanomaterials (CNMs) on plant growth and their potential applications in agriculture have attracted a great deal of attention from researchers. CNMs have been shown to promote nutrient absorption and increase plant growth. However, the mechanisms by which CNMs affect plant growth and nutrient absorption are still unknown. The tobacco seedling biomass, potassium (K+ ) concentration, and accumulation in hydroponic were investigated to exposure of carbon nanoparticles (CNPs). To directly observe the effect of CNPs on K+ uptake by roots, we employed a noninvasive micro-test technique (NMT) to detect the net flux of K+ on the surface of tobacco roots. The K+ -depletion experiment was carried out to explore the kinetic characteristics of K+ absorption, and qRT-PCR was used to monitor the expression levels of the K+ channel gene. The results showed that tobacco seedling biomass significantly improved at 10 mg·L-1 CNP treatments, and K+ concentration and accumulation both in roots and shoots increased with 10 and 20 mg·L-1 CNPs. CNP treatments changed the flow rate of K+ from efflux to influx in tobacco roots; this was observed both in plants cultivated in a CNP-containing medium and after the addition of CNPs to previously untreated plants. A depletion test also showed that CNPs improved the K+ absorption capacity and low-K+ tolerance of tobacco seedlings. CNPs enhanced the K+ absorption capacity and low-K+ tolerance of tobacco seedlings. The promotion of K+ absorption by CNPs was closely related to the activation of K+ influx channel genes and inhibition of the K+ outflow channel gene. The K+ flux response and ion channel gene expression to CNPs in plants reveal the mechanism whereby CNPs promote plant nutrient absorption.
{"title":"Carbon Nanoparticles Promoted the Absorption of Potassium Ions by\u0000Tobacco Roots via Regulation of K+ Flux and Ion Channel Gene\u0000Expression","authors":"Taibo Liang, Zhenjie Zhao, Huaxin Dai, Guiyao Wang, Yuhan Peng, Fu Liao, Ji-zhong Wu","doi":"10.2174/1573413719666230418110534","DOIUrl":"https://doi.org/10.2174/1573413719666230418110534","url":null,"abstract":"\u0000\u0000The regulatory effects of carbon nanomaterials (CNMs) on plant growth and\u0000their potential applications in agriculture have attracted a great deal of attention from researchers.\u0000CNMs have been shown to promote nutrient absorption and increase plant growth. However, the\u0000mechanisms by which CNMs affect plant growth and nutrient absorption are still unknown.\u0000\u0000\u0000\u0000The tobacco seedling biomass, potassium (K+\u0000) concentration, and accumulation in hydroponic were investigated to exposure of carbon nanoparticles (CNPs). To directly observe the effect of\u0000CNPs on K+ uptake by roots, we employed a noninvasive micro-test technique (NMT) to detect the\u0000net flux of K+ on the surface of tobacco roots. The K+\u0000-depletion experiment was carried out to explore\u0000the kinetic characteristics of K+ absorption, and qRT-PCR was used to monitor the expression levels\u0000of the K+ channel gene.\u0000\u0000\u0000\u0000The results showed that tobacco seedling biomass significantly improved at 10 mg·L-1 CNP\u0000treatments, and K+ concentration and accumulation both in roots and shoots increased with 10 and 20\u0000mg·L-1 CNPs. CNP treatments changed the flow rate of K+ from efflux to influx in tobacco roots; this\u0000was observed both in plants cultivated in a CNP-containing medium and after the addition of CNPs to\u0000previously untreated plants. A depletion test also showed that CNPs improved the K+ absorption capacity and low-K+ tolerance of tobacco seedlings.\u0000\u0000\u0000\u0000CNPs enhanced the K+ absorption capacity and low-K+ tolerance of tobacco seedlings.\u0000The promotion of K+ absorption by CNPs was closely related to the activation of K+ influx channel\u0000genes and inhibition of the K+ outflow channel gene. The K+ flux response and ion channel gene expression to CNPs in plants reveal the mechanism whereby CNPs promote plant nutrient absorption.\u0000","PeriodicalId":10827,"journal":{"name":"Current Nanoscience","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2023-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47943209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-17DOI: 10.2174/1573413719666230417085132
K. Yadav, Shivani Arora, Soma Yasaswi, Prabhuti Nirale, A. Solanki, Jnanadeva Bhat
Atorvastatin calcium (ATR) is a BCS class II drug showing poor bioavailability due to limited aqueous solubility. In the present study, a self-nano-emulsifying drug delivery system (SNEDDS) was developed and formulated as a liquid filled in a hard shell capsule to improve the bioavailability of ATR. Different oils were screened through the saturated stability method, and the amount of ATR solubilized in the respective oils was analysed through HPLC at 245nm. A ternary phase diagram was plotted to obtain the optimized ratio of oil, surfactant, and co-surfactant to formulate SNEDDS. The prepared ATR SNEDDS was filled into hard shell capsules, band sealed, and subjected to various evaluations like disintegration time, self-emulsification time, precipitation time assessment, globule size analysis and zeta potential. Then the in vitro dissolution studies were carried out. The optimized SNEDDS formulation was filled in a hard shell capsule, and in vivo studies were performed on rabbits to compare the pharmacokinetic parameters with the marketed formulation and pure ATR. In the present study a Self-nano-emulsifying drug delivery systems (SNEDDS) was developed and formulated as a Liquid filled in hard shell capsule to improve the bioavailability of ATR. Capmul MCM as the oil component showed five-fold solubility of ATR and was selected for the preparation of ATR-SNEDDS. The SNEDDS formulation showed an entrapment efficiency of 89.76±4.1% ATR with a globule size of 385±1.9 nm and an emulsification time of 5 seconds. It was established from the study that liquid ATR-SNEDDS had relative bioavailability enhanced by 1.7 times in comparison to the marketed formulations (Lipvas) and 4.8 times with respect to pure ATR. From the study, it was concluded that the bioavailability of ATR was enhanced by formulating ATR as Liquid SNEDDS filled in hard shell capsules.
{"title":"Self-nano-emulsifying drug delivery systems of Atorvastatin Calcium Liquid Filled in Hard Shell Capsules for Improved Oral Bioavailability in Rabbits","authors":"K. Yadav, Shivani Arora, Soma Yasaswi, Prabhuti Nirale, A. Solanki, Jnanadeva Bhat","doi":"10.2174/1573413719666230417085132","DOIUrl":"https://doi.org/10.2174/1573413719666230417085132","url":null,"abstract":"\u0000\u0000Atorvastatin calcium (ATR) is a BCS class II drug showing poor bioavailability due to limited aqueous solubility. In the present study, a self-nano-emulsifying drug delivery system (SNEDDS) was developed and formulated as a liquid filled in a hard shell capsule to improve the bioavailability of ATR.\u0000\u0000\u0000\u0000Different oils were screened through the saturated stability method, and the amount of ATR solubilized in the respective oils was analysed through HPLC at 245nm. A ternary phase diagram was plotted to obtain the optimized ratio of oil, surfactant, and co-surfactant to formulate SNEDDS. The prepared ATR SNEDDS was filled into hard shell capsules, band sealed, and subjected to various evaluations like disintegration time, self-emulsification time, precipitation time assessment, globule size analysis and zeta potential. Then the in vitro dissolution studies were carried out. The optimized SNEDDS formulation was filled in a hard shell capsule, and in vivo studies were performed on rabbits to compare the pharmacokinetic parameters with the marketed formulation and pure ATR.\u0000\u0000\u0000\u0000In the present study a Self-nano-emulsifying drug delivery systems (SNEDDS) was developed and formulated as a Liquid filled in hard shell capsule to improve the bioavailability of ATR.\u0000\u0000\u0000\u0000Capmul MCM as the oil component showed five-fold solubility of ATR and was selected for the preparation of ATR-SNEDDS. The SNEDDS formulation showed an entrapment efficiency of 89.76±4.1% ATR with a globule size of 385±1.9 nm and an emulsification time of 5 seconds. It was established from the study that liquid ATR-SNEDDS had relative bioavailability enhanced by 1.7 times in comparison to the marketed formulations (Lipvas) and 4.8 times with respect to pure ATR.\u0000\u0000\u0000\u0000From the study, it was concluded that the bioavailability of ATR was enhanced by formulating ATR as Liquid SNEDDS filled in hard shell capsules.\u0000","PeriodicalId":10827,"journal":{"name":"Current Nanoscience","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2023-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42964274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-17DOI: 10.2174/1573413719666230417103517
Poonam, S Kumar, R. Bhuvaneshwari, Sejal Jain, Shweta, Zainab Fatima, Dharmender Kumar, Bhupendra S. Chhikara, B. Rathi
Synthetic pesticides, crucial compounds for agricultural production, degrade quickly and damage the environment, hence solutions for their decreased usage or formulations with prolonged efficacy at low dosages are needed. Nanotechnology for nanosized formulations may reduce pesticide adverse effects. Nano-encapsulated pesticides made from nanocapsules, nanoemulsions, micelles, and nanogels outperform traditional pesticides with minimum environmental impact. Nanopesticides allowed target-based administration to decrease leaching and drainage into water bodies, and lower pesticide active component dosages. Nanocapsules with a core-shell configuration and a pesticide in the core are the most advantageous nanomaterials. Nanocapsules shield the active component. Stimuli-responsive nanocapsules may limit pesticide release by responding to pH, temperature, light, enzyme, or redox reactions. Toxicity prevents their use. This review discusses the latest developments in nanocapsule fabrication methods, their relevance, contemporary synthetic approaches to developing pesticide-loaded nanocapsules, and the features of these nanocomposites, with an emphasis on sustainable agricultural applications.
{"title":"A systematic review on Pesticide-loaded Nanocapsules: A Sustainable route for pesticide management to enhance crop productivity","authors":"Poonam, S Kumar, R. Bhuvaneshwari, Sejal Jain, Shweta, Zainab Fatima, Dharmender Kumar, Bhupendra S. Chhikara, B. Rathi","doi":"10.2174/1573413719666230417103517","DOIUrl":"https://doi.org/10.2174/1573413719666230417103517","url":null,"abstract":"\u0000\u0000Synthetic pesticides, crucial compounds for agricultural production, degrade quickly and\u0000damage the environment, hence solutions for their decreased usage or formulations with prolonged\u0000efficacy at low dosages are needed. Nanotechnology for nanosized formulations may reduce pesticide adverse effects. Nano-encapsulated pesticides made from nanocapsules, nanoemulsions, micelles, and nanogels outperform traditional pesticides with minimum environmental impact. Nanopesticides allowed target-based administration to decrease leaching and drainage into water bodies, and lower pesticide active component dosages. Nanocapsules with a core-shell configuration and\u0000a pesticide in the core are the most advantageous nanomaterials. Nanocapsules shield the active\u0000component. Stimuli-responsive nanocapsules may limit pesticide release by responding to pH, temperature, light, enzyme, or redox reactions. Toxicity prevents their use. This review discusses the\u0000latest developments in nanocapsule fabrication methods, their relevance, contemporary synthetic\u0000approaches to developing pesticide-loaded nanocapsules, and the features of these nanocomposites,\u0000with an emphasis on sustainable agricultural applications.\u0000","PeriodicalId":10827,"journal":{"name":"Current Nanoscience","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2023-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43120318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-13DOI: 10.2174/1573413719666230413084140
N. Mishra, M. Singhai, Ghanshyam Das Gupta, B. Khurana, Daisy Arora, Sumel Ashique
Cancer is a global public health issue; in the United States, it is the second leading cause of death. Furthermore, cancer, which consists of distinct subtypes of cancer cells and variable components, may cause a continuum of carcinogenesis. It can be categorized according to the part where it begins in the body, such as breast cancer or cervix cancer. Cervical cancer attacks cervix cells, most commonly in the transition area, when the endocervix's glandular cells transform into the exocervix's squamous cells. Cervical cancer is treated in several methods depending on the degree and size of the tumour and frequently entails surgery, radiotherapy, and chemotherapy. It is vital to have an effective drug delivery system that may increase the treatment effectiveness to overcome the limits of traditional therapy and achieve higher cancer therapeutic efficacy that is successful in treating cervical cancer. Additionally, these therapies are safer than traditional therapy. Although many nanocarriers have been created, only a few numbers have received clinical approval to deliver anticancer medications to the targeted areas where their predicted activity is to be seen. Along with the patents released, various research reports illustrating the value of nanocarriers are addressed in this review. Some recent publications, clinical evidence, and patent records on nanocarrier architectures have been given, strengthening the understanding of tumor management.
{"title":"Nanotechnology-Based Drug Delivery Systems for the Treatment of Cervical Cancer: A Comprehensive Review","authors":"N. Mishra, M. Singhai, Ghanshyam Das Gupta, B. Khurana, Daisy Arora, Sumel Ashique","doi":"10.2174/1573413719666230413084140","DOIUrl":"https://doi.org/10.2174/1573413719666230413084140","url":null,"abstract":"\u0000\u0000Cancer is a global public health issue; in the United States, it is the second leading cause of death. Furthermore, cancer, which consists of distinct subtypes of cancer cells and variable components, may cause a continuum of carcinogenesis. It can be categorized according to the part where it begins in the body, such as breast cancer or cervix cancer. Cervical cancer attacks cervix cells, most commonly in the transition area, when the endocervix's glandular cells transform into the exocervix's squamous cells. Cervical cancer is treated in several methods depending on the degree and size of the tumour and frequently entails surgery, radiotherapy, and chemotherapy.\u0000\u0000\u0000\u0000It is vital to have an effective drug delivery system that may increase the treatment effectiveness to overcome the limits of traditional therapy and achieve higher cancer therapeutic efficacy that is successful in treating cervical cancer.\u0000Additionally, these therapies are safer than traditional therapy. Although many nanocarriers have been created, only a few numbers have received clinical approval to deliver anticancer medications to the targeted areas where their predicted activity is to be seen.\u0000\u0000\u0000\u0000Along with the patents released, various research reports illustrating the value of nanocarriers are addressed in this review. Some recent publications, clinical evidence, and patent records on nanocarrier architectures have been given, strengthening the understanding of tumor management.\u0000","PeriodicalId":10827,"journal":{"name":"Current Nanoscience","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2023-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46837887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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