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Synthetic Strategies for Vitamin-loaded Carbon Dots and their Detection using Biosensors: A Review 含维生素碳点的合成策略及其生物传感器检测综述
4区 材料科学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Pub Date : 2023-10-05 DOI: 10.2174/0115734137252527230919110809
Himanshu Chaudhrya, Naresh K. Rangraa, Pooja A. Chawlaa
Abstract: Carbon dots belong to the class of nanomaterials invented accidentally and are attracting a lot of attention these days. Carbon dots are non-toxic, photostable, and easy-to-synthesize nano formulations having good water-soluble properties when treated chemically by manipulating surface active groups, followed by the addition of solubilizing agents and size reduction. These are widely used in bioimaging, electrochemical sensing, targeted drug delivery, and other biomedical activities. In recent years, significant attempts have been emphasized by analysts to the detection of vitamins embedded carbon dots using biosensors. The biosensing of vitamins has become easy due to the luminescence property of carbon dots, which makes them easy to detect. Therefore, in this review, we have reported synthetic strategies and recent biosensorbased detection techniques used in the analysis of vitamin-loaded carbon dots. Even from the carbon dot’s analytical perspective, there is still a lot of research needed in the area of biosensing, bioimaging, and healthcare applications. Unique features, along with the controllable synthesis methods, will lead to a bright future in the detection and characterization of drugs using carbon dots.
摘要:碳点属于偶然发明的一类纳米材料,近年来引起了人们的广泛关注。碳点是一种无毒、光稳定、易于合成的纳米配方,通过控制表面活性基团,然后添加增溶剂和缩小尺寸进行化学处理,具有良好的水溶性。它们广泛应用于生物成像、电化学传感、靶向药物传递和其他生物医学活动。近年来,利用生物传感器对嵌入碳点的维生素进行检测,受到了分析人士的重视。碳点的发光特性使其易于检测,从而使维生素的生物传感变得容易。因此,在这篇综述中,我们报道了合成策略和最近基于生物传感器的检测技术用于分析维生素负载碳点。即使从碳点的分析角度来看,在生物传感、生物成像和医疗保健应用领域仍有大量的研究需要进行。独特的特性,加上可控的合成方法,将在利用碳点检测和表征药物方面带来光明的前景。
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引用次数: 0
A Critical Review on Various Buffer Layers used to Enhance the Photovoltaic Performance of Organic Solar Cells 提高有机太阳能电池光电性能的缓冲层研究进展
4区 材料科学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Pub Date : 2023-10-04 DOI: 10.2174/0115734137268768230919170012
S. Sreejith, J. Ajayan, N.V. Uma Reddy, Manikandan M., Radhika J.M
Abstract: Due to the high need for sustainable energy sources, there has been a tremendous increase in SC (solar cell) production and research in recent years. Despite the fact that inorganic SC has led the SC consumer market due to its exceptional efficiency, its expensive and difficult manufacture method makes it unaffordable. Hence alternative technology for SC has been explored by researchers to overcome the draw backs of inorganic SC fabrication. OSC (organic solar cell) alternatively known as polymer SC has the advantage of having lightweight, low production cost, and simple device structure. During the last few years, significant attention has been given in order to overcome the material and technological barriers in OSC devices to make them commercially viable. Buffer layers play a significant part in improving the power conversion efficiencies in OSCs, thus it is necessary to comprehend the underlying microscopic mechanisms that underlie the advancements in order to support the current qualitative knowledge. In this review article, we have studied extensively the impact of different BLs (buffer-layer) in enhancing the PCE (power conversion efficiency) and absorption capabilities of OSCs.
摘要:由于对可持续能源的高度需求,近年来太阳能电池的生产和研究得到了极大的发展。尽管无机SC以其卓越的效率引领了SC消费市场,但其昂贵而困难的制造方法使其难以承受。因此,研究人员一直在探索SC的替代技术,以克服无机SC制造的缺点。有机太阳能电池(OSC)又称聚合物太阳能电池,具有重量轻、生产成本低、器件结构简单等优点。在过去的几年中,已经给予了很大的关注,以克服OSC装置的材料和技术障碍,使其在商业上可行。缓冲层在提高osc的功率转换效率方面发挥着重要作用,因此有必要了解这些进步背后的潜在微观机制,以支持当前的定性知识。在这篇综述文章中,我们广泛地研究了不同的BLs(缓冲层)对提高OSCs的PCE(功率转换效率)和吸收能力的影响。
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引用次数: 0
Hydrothermally Synthesized Boletus Brucella-derived Carbon Quantum Dots as a Fluorescent Probe for the Detection of Vitamin B2 水热合成布鲁氏菌衍生碳量子点作为荧光探针检测维生素B2
4区 材料科学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Pub Date : 2023-10-03 DOI: 10.2174/0115734137259719230921065320
Qiang Wan, Rong Li, Meiping Ren, Gang Ke
Background:: In the paper, Boletus Brucella was used as carbon source material to prepare carbon dots (CDs) by one-step hydrothermal method. The CDs had high quantum yield and high photostability. Methods:: A range of characterization studies were conducted on CDs, and the results showed that the average particle size of CDs was 5 nm, emitting blue fluorescence. The optimal excitation wavelength was 337 nm, and the emission wavelength was 440 nm. Results:: Based on the static quenching, the fluorescence of CDs could be effectively quenched by VB2. Therefore, a highly sensitive and selective fluorescent probe for detecting VB2 was constructed. The CDs were successfully used to detect tablets, human blood, and urine. Conclusion:: The recovery rate of VB2 was 97.55~99.45%, and the relative standard deviation was 1.29~3.76 (n=3). conclusion: The recovery rate of VB2 was 97.55~99.45%, and the relative standard deviation was 1.29~3.76 (n=3).
背景:本文以布鲁氏杆菌为碳源材料,采用一步水热法制备碳点(CDs)。该CDs具有高量子产率和光稳定性。方法:对CDs进行了一系列表征研究,结果表明CDs的平均粒径为5 nm,发出蓝色荧光。最佳激发波长为337 nm,发射波长为440 nm。结果:在静态猝灭的基础上,VB2能有效猝灭CDs的荧光。为此,构建了一种高灵敏度、高选择性的VB2荧光探针。该方法成功地用于药片、人体血液和尿液的检测。结论:VB2的回收率为97.55~99.45%,相对标准偏差为1.29~3.76 (n=3)。结论:VB2的回收率为97.55~99.45%,相对标准偏差为1.29~3.76 (n=3)。
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引用次数: 0
Study on Measurement Method of Three-dimensional Position of Unlabeled Microspheres under Bright Background 明亮背景下未标记微球三维位置测量方法研究
4区 材料科学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Pub Date : 2023-09-15 DOI: 10.2174/1573413719666230915103459
Ke Xu, Bingge Wang
Abstract: Using computer vision technology to obtain the position and trajectory data of particle probe microspheres from microscope images has significance and value in the molecular field. However, most of the existing microsphere measurement methods are based on transmission, which can only be measured under transparent samples and substrates and are not suitable for the application scenario of living cell measurement. In this paper, a method based on reflectivity imaging is proposed to measure the three-dimensional position of the dark microspheres in the bright field. Based on the outermost ring radius method, the relationship between the inner ring radius of the microsphere spot and the out-of-focus distance was explored to measure the coordinates in the Z direction. Cardiomyocytes were combined with 10um size silica microspheres. Experiments show that in a bright field with a high perturbation environment, it can achieve high precision measurement of dark microspheres and achieve three-dimensional position measurement with an accuracy of 50nm in XY direction and 100nm in Z direction.
摘要:利用计算机视觉技术从显微镜图像中获取粒子探针微球的位置和轨迹数据,在分子领域具有重要意义和价值。然而,现有的微球测量方法大多基于透射法,只能在透明的样品和底物下进行测量,不适合活细胞测量的应用场景。本文提出了一种基于反射率成像的暗微球在明光场中的三维位置测量方法。基于最外环半径法,探索微球光斑内环半径与离焦距离的关系,测量其Z方向坐标。心肌细胞与10um大小的二氧化硅微球结合。实验表明,在高摄动环境下的明亮场中,可以实现对暗微球的高精度测量,并实现XY方向50nm、Z方向100nm的三维位置测量。
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引用次数: 0
Surface-Enhanced Raman Scattering: A Promising Nanotechnology for Anti-Counterfeiting and Tracking Systems 表面增强拉曼散射:用于防伪和跟踪系统的有前途的纳米技术
4区 材料科学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Pub Date : 2023-09-01 DOI: 10.2174/1573413718666220607164053
Khaled Alkhuder
Abstract: Surface-enhanced Raman Scattering (SERS) is a sensing method based on inelastic scattering of a laser beam by a reporter molecule absorbed on a plasmonic substrate. The incident laser beam induces a localized-surface plasmon resonance in the substrate, which generates an oscillating electromagnetic field on the substrate dielectric surface. Under the influence of this field, the reporter molecule absorbed on the plasmonic substrate starts to vibrate, causing inelastic scattering of the laser beam. The laser-induced electromagnetic field is also the main contributor to the enhancement observed in the intensity of the scattered light. Plasmonic substrates are nanostructured surfaces often made of noble metals. The surface enhancement of a plasmonic substrate is determined primarily by factors related to the substrate’s nano-architecture and its composition. SERS-based labeling has emerged as a reliable and sophisticated anti-counterfeiting technology with potential applications in a wide range of industries. This technology is based on detecting the SERS signals produced by SERS tags using Raman spectroscopy. SERS tags are generally made of a plasmonic substrate, a Raman reporter, and a protective coating shell. They can be engineered using a wide variety of materials and methods. Several SERS-based anticounterfeiting labels have been developed in the past two decades. Some of these labels have been successfully combined with identification systems based on artificial intelligence. The purpose of this review is to shed light on the SERS technology and the progress that has been achieved in the SERS-based tracking systems.
摘要:表面增强拉曼散射(Surface-enhanced Raman Scattering, SERS)是一种利用等离子体基板上吸收的报告分子对激光束进行非弹性散射的传感方法。入射的激光束在衬底中产生局域表面等离子体共振,在衬底介质表面产生振荡电磁场。在该场的作用下,吸收在等离子体基板上的报告分子开始振动,引起激光束的非弹性散射。激光诱导的电磁场也是散射光强度增强的主要原因。等离子体衬底是纳米结构的表面,通常由贵金属制成。等离子体衬底的表面增强主要取决于衬底的纳米结构及其组成。基于sers的标签已经成为一种可靠和复杂的防伪技术,在广泛的行业中具有潜在的应用。该技术是基于使用拉曼光谱检测SERS标签产生的SERS信号。SERS标签通常由等离子基板、拉曼报告膜和保护涂层壳组成。它们可以使用各种各样的材料和方法来设计。在过去的二十年里,已经开发出了几种基于sers的防伪标签。其中一些标签已经成功地与基于人工智能的识别系统相结合。本综述的目的是阐明SERS技术及其在基于SERS的跟踪系统中取得的进展。
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引用次数: 1
Synthesis and antibacterial activity of ultrasmall silver nanoparticles by pulsed laser ablation in deionized water 在去离子水中脉冲激光烧蚀制备超小银纳米颗粒及其抗菌活性
4区 材料科学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Pub Date : 2023-08-31 DOI: 10.2174/1573413719666230831152658
Sarwin Yaseen Hussein, Tariq Abdul Hameed Abbas
Background: The main objective of this work is the synthesis and evaluation of silver nanoparticles (Ag NPs) by using pulsed laser ablation of a silver (Ag) target in deionized water and examining their antibacterial activity. Methods: Colloidal solutions of silver nanoparticles were prepared with different pulsed laser energies (620, 880, and 1000) mJ of wavelength 1064 nm and frequency 10 Hz. To determine their structure, optical, morphology, elemental composition, and infrared spectra, the synthesized Ag NPs were characterized using various high-throughput analytical techniques such as (UV-Vis) spectroscopy, transmission electron microgram (TEM), electron dispersive X-ray spectroscopy (EDX), Fourier transform infrared (FTIR) spectra, and Zeta potential. Results: The results show that the properties of synthesized Ag NPs depend much more on the laser energy. The laser energy can be used to control the properties of the prepared nanoparticles. Uniform distributions of spherical ultrasmall Ag NPs with an average size of (3) nm were obtained suspended in deionized water, which is the most effective size for antibacterial activity. However, the result indicated that the ablated Ag NPs were stable for 4 months in deionized water. The antibacterial activity of the colloidal solution of synthesized Ag NPs against Gram-negative Escherichia coli (E. coli) and Gram-positive Staphylococcus aureus (S. aureus) bacteria was then examined using the agar-well diffusion method. Conclusion: It was found that the prepared nanoparticles exhibited strong activity against E. coli and S. aureus bacteria growth. The average zones of inhibition of Ag NPs were found to be about (26) m¬¬¬¬¬¬m for E. coli and (32) mm for S. aureus bacteria.
背景:本工作的主要目的是利用脉冲激光烧蚀去离子水中的银靶合成和评价银纳米粒子(Ag NPs),并检测其抗菌活性。方法:以波长1064 nm,频率10 Hz的脉冲激光能量(620、880、1000)mJ制备纳米银胶体溶液。为了确定其结构、光学、形貌、元素组成和红外光谱,利用各种高通量分析技术,如(UV-Vis)光谱、透射电子显微图(TEM)、电子色散x射线光谱(EDX)、傅里叶变换红外(FTIR)光谱和Zeta电位对合成的Ag NPs进行了表征。结果:合成的银纳米粒子的性能与激光能量有很大的关系。激光能量可以用来控制制备的纳米颗粒的性能。在去离子水中获得了均匀分布的球形超微银纳米粒子,其平均粒径为(3)nm,是抗菌活性最有效的粒径。结果表明,烧蚀后的Ag NPs在去离子水中可以保持4个月的稳定。采用琼脂孔扩散法检测合成的银NPs胶体溶液对革兰氏阴性大肠杆菌(E. coli)和革兰氏阳性金黄色葡萄球菌(S. aureus)的抑菌活性。结论:制备的纳米颗粒对大肠杆菌和金黄色葡萄球菌的生长具有较强的抑制作用。Ag NPs对大肠杆菌和金黄色葡萄球菌的平均抑制区分别为(26)mm和(32)mm。
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引用次数: 0
Fabrication of graphene-based ammonia sensors: a review 石墨烯基氨传感器的制备研究进展
IF 1.5 4区 材料科学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Pub Date : 2023-08-29 DOI: 10.2174/1573413719666230829142724
Ke Xu, Wei Zheng
Graphene gas sensors have gained much scientific interest due to their high sensitivity, selectivity, and fast detection of various gases. This article summarizes the research progress of graphene gas sensors for detecting ammonia gas at room temperature. Firstly, the performance and development trends of the graphene/semiconductor Schottky diode sensor are discussed. Secondly, manufacturing methods and the latest developments in graphene field-effect transistor sensors are reviewed. Finally, the basic challenges and latest efforts of functional ammonia gas sensors are studied. The discussion delves into each sensor type's detection principles and performance indicators, including selectivity, stability, measurement range, response time, recovery time, and relative humidity. A comparative analysis is conducted to highlight the progress achieved in research, elucidating the advantages, disadvantages, and potential solutions associated with various sensors. As a result, the paper concludes by exploring the future development prospects of graphene-based ammonia sensors.
石墨烯气体传感器由于其高灵敏度、选择性和对各种气体的快速检测而引起了科学界的广泛关注。本文综述了用于室温下氨气检测的石墨烯气体传感器的研究进展。首先,讨论了石墨烯/半导体肖特基二极管传感器的性能和发展趋势。其次,综述了石墨烯场效应晶体管传感器的制备方法和最新进展。最后,对功能性氨气传感器的基本挑战和最新进展进行了研究。讨论深入到每个传感器类型的检测原理和性能指标,包括选择性,稳定性,测量范围,响应时间,恢复时间和相对湿度。通过比较分析,突出了研究进展,阐明了各种传感器的优点、缺点和潜在的解决方案。因此,本文最后探讨了石墨烯基氨传感器的未来发展前景。
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引用次数: 0
Synthesis and Characterization of Carbon Nano Sphere-doped Gd: Alpha Sb2O4Nanostructure for High-Performance Energy Storage Applications 碳纳米球掺杂Gd: Alpha sb2o4纳米结构的合成与表征
IF 1.5 4区 材料科学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Pub Date : 2023-07-20 DOI: 10.2174/1573413719666230720161905
W. Nabgan, V. Adimule, Parashuram Laxminarayana, Kalpana Sharma, Nidhi Manhas
To enhance the super capacitive properties of nanocomposites, the effective method is to combine carbon nanospheres with mesoporous structures with Gd3+:α-Sb2O4 inorganic nanocomposites (NC) to form hybrid electrodes. An as-prepared hybrid electrode material possesses increased energy density, high rate of reversibility and cyclic stability when incorporated in electrochemical cyclic voltammetric studies.In the present investigation, various wt % of C-nanospheres (Cx) (5 %, 10% and 20%) were decorated over Gd3+: α-Sb2O4 nanocomposites and were synthesized by coprecipitation method. XRD, SEM, EDX, UV-visible, and XPS are only a few of the analytical techniques used to describe the as-prepared hybrid nanocomposites. Electrochemical cyclic voltammetry was carried out in a 6M KOH solution, three-electrode system.The crystal structure and morphology of Cx: Gd3+@ α-Sb2O4 NC showed a mixed hexagonal phase and agglomerated tiny irregularly shaped morphology that appeared as the Cx concentration increased. Redshift in optical absorption peak appeared (near UV-edge), and the optical band gap (Eg) value increased from 3.53 eV to 3.65 eV. The electrochemical supercapacitor showed the highest specific capacitance of 989 F/g at the current density of 1 A/g for C20%:Gd3+@α-Sb2O4 NC compared with Cx:Gd3+@α-Sb2O4 (x = 5 % and 10 %) and undoped Gd3+:α-Sb2O4 NC. The change in phase angle and Rs value of 1.98 was attributed to the ideal supercapacitor properties. The cyclic stability after 5000 cycles with 79.71 % capacitive retention was exhibited by C20%:Gd3+@α-Sb2O4 NC.The present research introduces ease of synthesis of hybrid electrode materials possessing high active surface area, increased energy density, high cyclic stability, and reversibility in an aqueous solution.
为了提高纳米复合材料的超级电容性能,将具有介孔结构的碳纳米球与Gd3+:α-Sb2O4无机纳米复合材料(NC)结合形成杂化电极是有效的方法。制备的杂化电极材料在电化学循环伏安研究中具有较高的能量密度、高的可逆性和循环稳定性。本研究采用共沉淀法在Gd3+: α-Sb2O4纳米复合材料上修饰不同wt %的c -纳米微球(Cx),分别为5%、10%和20%。XRD, SEM, EDX, UV-visible和XPS只是用于描述制备的杂化纳米复合材料的几种分析技术。在6M KOH溶液、三电极体系中进行了电化学循环伏安法。Cx: Gd3+@ α-Sb2O4 NC的晶体结构和形貌表现为混合六方相,并随着Cx浓度的增加而出现微小的不规则形状的聚集形貌。光学吸收峰出现红移(近紫外边),光学带隙(Eg)值由3.53 eV增加到3.65 eV。与未掺杂Gd3+:α-Sb2O4 NC和Cx:Gd3+@α-Sb2O4 NC相比,C20%:Gd3+@α-Sb2O4 NC在电流密度为1 A/g时比电容最高,为989 F/g。相位角的变化和Rs值的1.98归因于理想的超级电容器特性。C20%:Gd3+@α-Sb2O4 NC在5000次循环后表现出79.71%的电容保留率。本研究介绍了易于合成的杂化电极材料,具有高活性表面积,增加能量密度,高循环稳定性和在水溶液中的可逆性。
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引用次数: 0
Recent advances in the nanotechnology-based applications of essential oils 基于纳米技术的精油应用的最新进展
IF 1.5 4区 材料科学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Pub Date : 2023-07-18 DOI: 10.2174/1573413719666230718122527
Feng He, Lei Zhang, Jingyi Lin, Can Zhang, Sijing Hu, Yang Dong, Guanwei Fan
Essential oils (EOs), which are volatile aromatic substances extracted from plants, exhibit antibacterial, antitumor, antiviral, antioxidant, anti-inflammatory, and other effects. Eos are widely used in different fields because of their various biological activities. EOs are volatile and insoluble in water, so their effective utilization rate is greatly reduced. In this regard, researchers propose to use nanotechnology to construct an EOs nanosystem to solve the application problems and improve the utilization rate of EOs. This review summarizes the latest research progress and application status of EOs nanocapsules, EOs nanoemulsion, EOs nanofiber membrane, EOs nanoparticles and EOs nanoliposome, including the methodologies, characteristics and applications.Analyzes the advantages and disadvantages of existing EOs nanotechnology and provides an outlook for future development.
精油是一种从植物中提取的挥发性芳香物质,具有抗菌、抗肿瘤、抗病毒、抗氧化、抗炎等作用。因其具有多种生物活性,被广泛应用于不同领域。EOs易挥发且不溶于水,因此其有效利用率大大降低。为此,研究人员提出利用纳米技术构建EOs纳米系统,以解决EOs的应用问题,提高EOs的利用率。本文综述了EOs纳米胶囊、EOs纳米乳、EOs纳米纤维膜、EOs纳米颗粒和EOs纳米脂质体的最新研究进展和应用现状,包括EOs的研究方法、特点和应用。分析了现有EOs纳米技术的优缺点,并对未来的发展进行了展望。
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引用次数: 0
Virus-like Particles for Disease Diagnosis and Drug Delivery Applications 用于疾病诊断和药物递送应用的病毒样颗粒
IF 1.5 4区 材料科学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Pub Date : 2023-07-17 DOI: 10.2174/1573413719666230717123734
R. Malviya, Rishav Sharma
Virus-like particles (VLPs) are nanoscale, self-assembling cage structures made out of proteins with practical uses in biomedicine. They might be used to create better vaccinations, imaging equipment, gene and drug therapy delivery systems, and in vitro diagnostic equipment. VLPs are nanostructures that might be used in medicine, immunization, and diagnostics, among other areas. Many VLPs-based vaccines are now in use for the treatment of infectious diseases, and many more are on their way to clinical testing thanks to recent advancements in biomedical engineering. Although VLPs exhibit promising qualities in terms of efficacy, safety, and diversity, they may become more widely used in the future. Vaccines based on virus-like particles (VLPs) might serve as an effective addition to current immunization strategies for the prevention and treatment of emerging infectious diseases. The growing field of healthcare prevention has become increasingly interested in VLPs, leading to the discovery of various VLP-based candidate vaccines for vaccination towards a wide range of infectious pathogens, one of the most recent that has been developed is the vaccine against SARS-CoV-2, the effectiveness of that is now being tested. VLPs can elicit both antibody and cell-mediated immune responses, unlike standard inactivated viral vaccines. However, several problems persist with this surface display method and will need fixing in the future. VLPs-based medicinal delivery, nanoreactors for treatment, and imaging systems are being developed with promising results. The latest developments in the generation and fabrication of VLPs involve explorations of several expression systems for their creation and their application as vaccines for the avoidance of infectious diseases and malignancies. This manuscript offers the most advanced perspective on biomedical applications based on VLPs, as well as details innovative methods for manufacturing, functionalization, and delivery of VLPs.
病毒样颗粒(VLP)是由蛋白质制成的纳米级自组装笼状结构,在生物医学中具有实际用途。它们可能被用于制造更好的疫苗接种、成像设备、基因和药物治疗递送系统以及体外诊断设备。VLP是一种纳米结构,可用于医学、免疫和诊断等领域。许多基于VLP的疫苗目前正在用于治疗传染病,由于生物医学工程的最新进展,更多的疫苗正在进行临床测试。尽管VLP在疗效、安全性和多样性方面表现出有希望的品质,但它们在未来可能会得到更广泛的应用。基于病毒样颗粒(VLP)的疫苗可能是目前预防和治疗新发传染病的免疫策略的有效补充。日益增长的医疗保健预防领域对VLP越来越感兴趣,从而发现了各种基于VLP的候选疫苗,用于针对各种传染性病原体进行疫苗接种,最近开发的疫苗之一是针对严重急性呼吸系统综合征冠状病毒2型的疫苗,其有效性目前正在测试中。与标准灭活病毒疫苗不同,VLP可以引发抗体和细胞介导的免疫反应。然而,这种表面显示方法仍然存在一些问题,并且在未来需要解决。基于VLP的药物递送、用于治疗的纳米反应器和成像系统正在开发中,并取得了有希望的结果。VLP的产生和制造的最新进展涉及对其产生的几种表达系统的探索,以及其作为避免传染病和恶性肿瘤的疫苗的应用。本文提供了基于VLP的生物医学应用的最先进视角,并详细介绍了VLP的制造、功能化和递送的创新方法。
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引用次数: 0
期刊
Current Nanoscience
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