Pub Date : 2024-06-03DOI: 10.2174/0124054615297377240524043453
Sangita R. Bhirud, C. Sarode, Gaurav R. Gupta, G. Chaudhari
Ionic liquids belong to the class of green solvents and are distinguished by their simple yet distinctive physical properties that are related to their structure. These properties include their remarkable thermal stability, exceptional thermal conductivity, and negligible vapor pressure. Additionally, they are suitable and inert for a wide range of catalytic applications. Zinc Oxide Nanoparticles (ZnO-NPs) have been considered a cost-effective choice that requires modest reaction conditions to provide a high yield of the required products with remarkable selectivity in a short amount of time. Consequently, an investigation into the synthesis of ZnO-NPs in an ionic liquid medium has been attempted in the current work. The synthesis of metal nanoparticles using highly tunable ionic liquids is being investigated for many pharmacological applications and their usage in catalysis. In this context, the current work has used the co-precipitation approach to synthesize ZnO-NPs. The production of ZnO nanoparticles with a range of morphologies utilizing an imidazolium ionic liquid system has been the main topic of discussion. The co-precipitation method has successfully been administered for the synthesis of morphologically diverse nano-crystalline ZnO particles using different ionic liquids, such as 1-propyl- 3-methylimidazolium bromide (pmim)(Br), 1-butyl-3-methylimidazolium bromide ([bmim][Br]), and 1-hexyl-3-methylimidazolium bromide (hmim)(Br) as an additive Modern analytical tools, including X-ray Diffraction (XRD), Scanning Electron Microscopy (SEM), and FT-IR absorption spectroscopy have been employed to confirm the structure of these ZnO nanoparticles. The IR absorption peak below 480 cm-1 and the XRD pattern showed all the peaks in the diffraction diagram, revealing the formation of ZnO-NPs. FE-SEM images showed various morphologies of ZnO-NPs and they have been found to be separated from the agglomerated clusters. The characteristic results have revealed ionic liquids to have substantial effects on the size of the zinc nano-species as well as provide the appropriate environment for the growth of the nanoparticles.
{"title":"Ionic Liquids as an Efficient Reaction Medium in the Robust Synthesis of\u0000ZnO Nanoparticles","authors":"Sangita R. Bhirud, C. Sarode, Gaurav R. Gupta, G. Chaudhari","doi":"10.2174/0124054615297377240524043453","DOIUrl":"https://doi.org/10.2174/0124054615297377240524043453","url":null,"abstract":"\u0000\u0000Ionic liquids belong to the class of green solvents and are distinguished by their\u0000simple yet distinctive physical properties that are related to their structure. These properties include\u0000their remarkable thermal stability, exceptional thermal conductivity, and negligible vapor pressure.\u0000Additionally, they are suitable and inert for a wide range of catalytic applications. Zinc Oxide Nanoparticles\u0000(ZnO-NPs) have been considered a cost-effective choice that requires modest reaction\u0000conditions to provide a high yield of the required products with remarkable selectivity in a short\u0000amount of time. Consequently, an investigation into the synthesis of ZnO-NPs in an ionic liquid\u0000medium has been attempted in the current work.\u0000\u0000\u0000\u0000The synthesis of metal nanoparticles using highly tunable ionic liquids is being investigated\u0000for many pharmacological applications and their usage in catalysis.\u0000\u0000\u0000\u0000In this context, the current work has used the co-precipitation approach to synthesize\u0000ZnO-NPs. The production of ZnO nanoparticles with a range of morphologies utilizing an imidazolium\u0000ionic liquid system has been the main topic of discussion.\u0000\u0000\u0000\u0000The co-precipitation method has successfully been administered for the synthesis of morphologically\u0000diverse nano-crystalline ZnO particles using different ionic liquids, such as 1-propyl-\u00003-methylimidazolium bromide (pmim)(Br), 1-butyl-3-methylimidazolium bromide ([bmim][Br]),\u0000and 1-hexyl-3-methylimidazolium bromide (hmim)(Br) as an additive\u0000\u0000\u0000\u0000Modern analytical tools, including X-ray Diffraction (XRD), Scanning Electron Microscopy\u0000(SEM), and FT-IR absorption spectroscopy have been employed to confirm the structure of\u0000these ZnO nanoparticles. The IR absorption peak below 480 cm-1 and the XRD pattern showed all\u0000the peaks in the diffraction diagram, revealing the formation of ZnO-NPs. FE-SEM images showed\u0000various morphologies of ZnO-NPs and they have been found to be separated from the agglomerated\u0000clusters.\u0000\u0000\u0000\u0000The characteristic results have revealed ionic liquids to have substantial effects on the\u0000size of the zinc nano-species as well as provide the appropriate environment for the growth of the\u0000nanoparticles.\u0000","PeriodicalId":10924,"journal":{"name":"Current Nanomaterials","volume":"193 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141388733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A brake pad is an integral component of a vehicle's braking system, designed to impart controlled friction and, ultimately, assist in slowing or stopping a vehicle. Their constituents include binder, filler, abrasive, lubricant, and reinforcing fiber. Materials for brake pads must have excellent wear resistance, increased heat dissipation, a consistent coefficient of friction, low noise and vibration, durability, compatibility, minimal environmental impact, and cost-effectiveness. This paper aims to examine the various materials used in brake pad applications. They are composed of matrix, ceramic, and polymer composites, and are manufactured using various processes. In addition to mechanical and tribological testing, there are various methods for testing the mechanical and tribological properties of brake pads. Various instruments, such as SEM, TEM, AFM, and XRD, were surveyed in order to analyse the morphology and crystal structure of nanoscale brake pads. Various applications such as automobiles, railroads, and aerospace utilise brake pads. The study reveals that integrating nano-fillers into polymer composites significantly enhances the mechanical and tribological properties of automotive brake pads, offering a promising route toward more durable, efficient, and safer braking systems. Through this analysis, researchers will gain a deeper understanding of the materials used in brake pads and their adaptability for various applications.
{"title":"Analyzing Tribological and Mechanical Properties of Polymer\u0000Nanocomposite for Brake Pad Applications - A Critical Review","authors":"Yagnik Patel, Unnati Joshi, Anand Joshi, Ankit D. Oza, Vijay Patel, Laxman Singh","doi":"10.2174/0124054615284437240528101620","DOIUrl":"https://doi.org/10.2174/0124054615284437240528101620","url":null,"abstract":"\u0000\u0000A brake pad is an integral component of a vehicle's braking system, designed to impart\u0000controlled friction and, ultimately, assist in slowing or stopping a vehicle. Their constituents include\u0000binder, filler, abrasive, lubricant, and reinforcing fiber. Materials for brake pads must have\u0000excellent wear resistance, increased heat dissipation, a consistent coefficient of friction, low\u0000noise and vibration, durability, compatibility, minimal environmental impact, and cost-effectiveness.\u0000This paper aims to examine the various materials used in brake pad applications. They are\u0000composed of matrix, ceramic, and polymer composites, and are manufactured using various processes.\u0000In addition to mechanical and tribological testing, there are various methods for testing\u0000the mechanical and tribological properties of brake pads. Various instruments, such as SEM,\u0000TEM, AFM, and XRD, were surveyed in order to analyse the morphology and crystal structure\u0000of nanoscale brake pads. Various applications such as automobiles, railroads, and aerospace utilise\u0000brake pads. The study reveals that integrating nano-fillers into polymer composites significantly\u0000enhances the mechanical and tribological properties of automotive brake pads, offering a\u0000promising route toward more durable, efficient, and safer braking systems. Through this analysis,\u0000researchers will gain a deeper understanding of the materials used in brake pads and their adaptability\u0000for various applications.\u0000","PeriodicalId":10924,"journal":{"name":"Current Nanomaterials","volume":"13 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141388298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
New nanoparticles (NPs) and biomaterials are utilized more frequently in biological research for vaccinations, diagnostic procedures, and drug administration. Nanomaterials are materials with d50 value from 1 to 100nm. They are also found in various consumer goods, the environment, and work. Thus, it has become crucial for the appropriate development of nanotechnology to assess the safety and potential therapeutic applications of these nanomaterials. The BCS Cass II medication pioglitazone hydrochloride, used to treat hypoglycaemia, has poor bioavailability after oral treatment because it dissolves poorly in gastrointestinal fluids. New nanoparticles and biomaterials are utilized more frequently in biological research for vaccinations, diagnostic procedures, and drug administration. They are also found in various consumer goods, the environment, and work. Thus, it has become crucial for the appropriate development of nanotechnology to assess the safety and potential therapeutic applications of these nanomaterials. The BCS Cass II medication pioglitazone hydrochloride, used to treat hypoglycaemia, has poor bioavailability after oral treatment because it dissolves poorly in gastrointestinal fluids. This study aimed to create adjusted pioglitazone nanoparticles to decrease dose-related side effects and prolong its release when used against type 2 diabetes. This study aimed to create adjusted pioglitazone nanoparticles to decrease dose-related side effects and prolong its release when used against type 2 diabetes The emulsion solvent evaporation approach was used to create nanoparticles utilising HPMC K15M and Eudragit S100 as polymers, and Tween 80 as a surfactant. On framed nanoparticles, in-vitro evaluation approaches for drug-polymer compatibility, percentage yield, particle size, zeta potential, polydispersity index, surface morphology, encapsulation effectiveness, and in-vitro drug release study were used, followed by in-vivo acute toxicity experiment. From the obtained data, it can be said that a suitable optimized formulation of pioglitazone nanoparticles was prepared, which offered extended drug release of 95% in 10 hours.
{"title":"Pioglitazone Nanoparticles Development, Characterization, Optimization, and a Zebrafish Model Evaluation of its Teratogenic Safety","authors":"Plaban Saha, Subhajit Sarkar, Rakesh Ghosh, Mainak Chakraborty, Swarupananda Mukherjee, D. Karati","doi":"10.2174/0124054615263163231024045123","DOIUrl":"https://doi.org/10.2174/0124054615263163231024045123","url":null,"abstract":"\u0000\u0000New nanoparticles (NPs) and biomaterials are utilized more frequently in\u0000biological research for vaccinations, diagnostic procedures, and drug administration. Nanomaterials\u0000are materials with d50 value from 1 to 100nm. They are also found in various consumer goods, the\u0000environment, and work. Thus, it has become crucial for the appropriate development of nanotechnology\u0000to assess the safety and potential therapeutic applications of these nanomaterials. The BCS\u0000Cass II medication pioglitazone hydrochloride, used to treat hypoglycaemia, has poor bioavailability\u0000after oral treatment because it dissolves poorly in gastrointestinal fluids.\u0000\u0000\u0000\u0000New nanoparticles and biomaterials are utilized more frequently in biological research for vaccinations, diagnostic procedures, and drug administration. They are also found in various consumer goods, the environment, and work. Thus, it has become crucial for the appropriate development of nanotechnology to assess the safety and potential therapeutic applications of these nanomaterials. The BCS Cass II medication pioglitazone hydrochloride, used to treat hypoglycaemia, has poor bioavailability after oral treatment because it dissolves poorly in gastrointestinal fluids.\u0000\u0000\u0000\u0000This study aimed to create adjusted pioglitazone nanoparticles to decrease dose-related\u0000side effects and prolong its release when used against type 2 diabetes.\u0000\u0000\u0000\u0000This study aimed to create adjusted pioglitazone nanoparticles to decrease dose-related side effects and prolong its release when used against type 2 diabetes\u0000\u0000\u0000\u0000The emulsion solvent evaporation approach was used to create nanoparticles utilising\u0000HPMC K15M and Eudragit S100 as polymers, and Tween 80 as a surfactant. On framed nanoparticles,\u0000in-vitro evaluation approaches for drug-polymer compatibility, percentage yield, particle size,\u0000zeta potential, polydispersity index, surface morphology, encapsulation effectiveness, and in-vitro\u0000drug release study were used, followed by in-vivo acute toxicity experiment.\u0000\u0000\u0000\u0000From the obtained data, it can be said that a suitable optimized formulation of pioglitazone\u0000nanoparticles was prepared, which offered extended drug release of 95% in 10 hours.\u0000","PeriodicalId":10924,"journal":{"name":"Current Nanomaterials","volume":" 13","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140687347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-16DOI: 10.2174/0124054615293683240405060440
Shivangi Sharma, S. Mohanalakhmi
Conducting polymers (CPs) have garnered a lot of attention in recent years due to the financial significance they have, the high environmental stability they exhibit, the electrical conductivity they possess, and the beneficial mechanical, optical, and electronic qualities they possess. Conducting polymers have a wide range of uses, including but not limited to the following: diodes, transistors, artificial nerves, aviation construction, conducting adhesives, electromagnetic shielding against electromagnetic interference (EMI), and electrostatic materials. These nanofibers and nanotubes have a wide range of potential applications, including but not limited to: actuators, drug delivery, brain interfaces, nanodiodes, field emission and electrochromic displays, supercapacitors and energy storage, sensors, nanodiodes, field effect transistors, drug delivery, and protein purification. The purpose of this review is to discuss a few of these applications as well as their possible applications in the future.
{"title":"Conducting Polymer Nanofibers and Nanotubes as a Potential\u0000Nanotechnology: Current Status and Future Directions","authors":"Shivangi Sharma, S. Mohanalakhmi","doi":"10.2174/0124054615293683240405060440","DOIUrl":"https://doi.org/10.2174/0124054615293683240405060440","url":null,"abstract":"\u0000\u0000Conducting polymers (CPs) have garnered a lot of attention in recent years due to the\u0000financial significance they have, the high environmental stability they exhibit, the electrical conductivity they possess, and the beneficial mechanical, optical, and electronic qualities they possess.\u0000Conducting polymers have a wide range of uses, including but not limited to the following: diodes,\u0000transistors, artificial nerves, aviation construction, conducting adhesives, electromagnetic shielding\u0000against electromagnetic interference (EMI), and electrostatic materials. These nanofibers and nanotubes have a wide range of potential applications, including but not limited to: actuators, drug delivery, brain interfaces, nanodiodes, field emission and electrochromic displays, supercapacitors and\u0000energy storage, sensors, nanodiodes, field effect transistors, drug delivery, and protein purification.\u0000The purpose of this review is to discuss a few of these applications as well as their possible applications in the future.\u0000","PeriodicalId":10924,"journal":{"name":"Current Nanomaterials","volume":"354 14‐15","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140698174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-05DOI: 10.2174/0124054615282618240329063241
Deepak Kohli, D. S. Panwar, Balraj Tudu, Jigesh Mehta, Vishal Shah, Jigna Patel, Bital Patel, Ankit D. Oza, Ravi Gupta, Laxman Singh
The present work shows the effect of Bentonite Clay (BC) on the biodegradation behavior of Poly Vinyl Alcohol (PVA)/Banana Peel Nano Crystals (BPNC) composite films. Nowadays, composite films manufactured from biodegradable or partially biodegradable polymers reinforced natural fillers start to gain attention because they are considered as one of the environmentally friendly biomaterials Biodegradation studies were conducted using soil burial and bacterial degradation method. The prepared composite films were characterized by scanning electron microscopy. Biodegradation studies reported that the composite films were more degradable in bacterial environment as compared to natural soil burial. The addition of Bentonite Clay (BC) had negative effect on degradation rate of composite films. Biodegradation studies were conducted using soil burial and bacterial degradation method. The prepared composite films were characterized by scanning electron microscopy. PVA/BPNC/BC composite film showed less weight loss (%) as compared to PVA/BPNC composite films because BC had stabilizing effect against the microbial attack which prevents biodegradation.
本研究显示了膨润土（BC）对聚乙烯醇（PVA）/香蕉皮纳米晶体（BPNC）复合薄膜生物降解行为的影响。如今，由可生物降解或部分可生物降解聚合物增强天然填料制成的复合薄膜开始受到关注，因为它们被认为是环境友好型生物材料之一。生物降解研究表明，与自然土壤埋藏法相比，复合薄膜在细菌环境中更容易降解。生物降解研究采用土壤埋藏法和细菌降解法进行。与 PVA/BPNC 复合薄膜相比，PVA/BPNC/BC 复合薄膜的重量损失（%）较少，这是因为 BC 具有稳定微生物的作用，可防止生物降解。
{"title":"Environmentally Compatible Poly (Vinyl Alcohol)/Banana Peel Nano Crystals/Bentonite Clay-based Composites Films: Influence of Nano Filler\u0000on Biodegradation Behavior","authors":"Deepak Kohli, D. S. Panwar, Balraj Tudu, Jigesh Mehta, Vishal Shah, Jigna Patel, Bital Patel, Ankit D. Oza, Ravi Gupta, Laxman Singh","doi":"10.2174/0124054615282618240329063241","DOIUrl":"https://doi.org/10.2174/0124054615282618240329063241","url":null,"abstract":"\u0000\u0000The present work shows the effect of Bentonite Clay (BC) on the biodegradation\u0000behavior of Poly Vinyl Alcohol (PVA)/Banana Peel Nano Crystals (BPNC) composite films.\u0000\u0000\u0000\u0000Nowadays, composite films manufactured from biodegradable or partially biodegradable polymers reinforced natural fillers start to gain attention because they are considered as one of the environmentally friendly biomaterials\u0000\u0000\u0000\u0000Biodegradation studies were conducted using soil burial and bacterial degradation method.\u0000The prepared composite films were characterized by scanning electron microscopy.\u0000\u0000\u0000\u0000Biodegradation studies reported that the composite films were more degradable in bacterial\u0000environment as compared to natural soil burial. The addition of Bentonite Clay (BC) had negative\u0000effect on degradation rate of composite films.\u0000\u0000\u0000\u0000Biodegradation studies were conducted using soil burial and bacterial degradation method. The prepared composite films were characterized by scanning electron microscopy.\u0000\u0000\u0000\u0000PVA/BPNC/BC composite film showed less weight loss (%) as compared to\u0000PVA/BPNC composite films because BC had stabilizing effect against the microbial attack which\u0000prevents biodegradation.\u0000","PeriodicalId":10924,"journal":{"name":"Current Nanomaterials","volume":"205 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140740436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-03DOI: 10.2174/0124054615284528240201105900
Tekileab Engida Gebremichael, G. G. Muleta, Kirubel Teshome Tadele
The rise of infectious diseases especially due to drug-resistant microbes and free radicals has caused a serious threat to public health worldwide. Green synthesized nanomaterials (NMs) have emerged as promising candidates to minimize the damage due to these problems. Doping the bioactive and stable silver atom into the biocompatible CuO by capping the nanoparticles with phytochemicals from honey enhanced the biological activity. The present study aimed to synthesize Ag- CuO NCs using the honey solution for antimicrobial and antioxidant activity evaluation. The nanoparticles (NPs) and nanocomposites (NCs) were successfully synthesized using the honey solution and characterized by spectroscopic techniques such as XRD, UV-Vis, FTIR, and SEM. The role of the secondary metabolites in honey solution is to stabilize the fabricated NMs by capping. The red shift observed with the addition of Ag dopant indicates the narrowing of the CuO band gap. FT-IR characterization confirmed the presence of various functional group bands in the synthesized NMs. The spectral band between 900–500 cm−1 displays the presence of metal-oxygen and metal-metal bonds, confirming the production of pure CuO NPs and Ag-CuO NCs. The fabricated CuO NPs and Ag-CuO NCs have crystalline structures with crystallite sizes of 14.14 and 17.40 nm respectively. SEM data showed that CuO NPs are spherical and Ag-CuO NCs have a mixture of spherical and cubic shapes. The NMs displayed concentration-dependent biological activities. The successful incorporation of silver into the crystal lattice of CuO integrated with the presence of secondary metabolites on the surface improved the potential. Hence, the prepared NMs may have pharmaceutical applications in the future with some modifications for the enhancement of their potential.
{"title":"Green Synthesis of Ag-Doped CuO Nanocomposites Using Honey Solution for Evaluation of their Antimicrobial and Antioxidant Activities","authors":"Tekileab Engida Gebremichael, G. G. Muleta, Kirubel Teshome Tadele","doi":"10.2174/0124054615284528240201105900","DOIUrl":"https://doi.org/10.2174/0124054615284528240201105900","url":null,"abstract":"\u0000\u0000The rise of infectious diseases especially due to drug-resistant microbes\u0000and free radicals has caused a serious threat to public health worldwide. Green synthesized nanomaterials\u0000(NMs) have emerged as promising candidates to minimize the damage due to these problems.\u0000Doping the bioactive and stable silver atom into the biocompatible CuO by capping the nanoparticles\u0000with phytochemicals from honey enhanced the biological activity. The present study aimed\u0000to synthesize Ag- CuO NCs using the honey solution for antimicrobial and antioxidant activity evaluation.\u0000\u0000\u0000\u0000The nanoparticles (NPs) and nanocomposites (NCs) were successfully synthesized using\u0000the honey solution and characterized by spectroscopic techniques such as XRD, UV-Vis, FTIR, and\u0000SEM. The role of the secondary metabolites in honey solution is to stabilize the fabricated NMs by\u0000capping.\u0000\u0000\u0000\u0000The red shift observed with the addition of Ag dopant indicates the narrowing of the CuO\u0000band gap. FT-IR characterization confirmed the presence of various functional group bands in the\u0000synthesized NMs. The spectral band between 900–500 cm−1 displays the presence of metal-oxygen\u0000and metal-metal bonds, confirming the production of pure CuO NPs and Ag-CuO NCs. The fabricated\u0000CuO NPs and Ag-CuO NCs have crystalline structures with crystallite sizes of 14.14 and 17.40\u0000nm respectively. SEM data showed that CuO NPs are spherical and Ag-CuO NCs have a mixture of\u0000spherical and cubic shapes. The NMs displayed concentration-dependent biological activities.\u0000\u0000\u0000\u0000The successful incorporation of silver into the crystal lattice of CuO integrated with\u0000the presence of secondary metabolites on the surface improved the potential. Hence, the prepared\u0000NMs may have pharmaceutical applications in the future with some modifications for the enhancement\u0000of their potential.\u0000","PeriodicalId":10924,"journal":{"name":"Current Nanomaterials","volume":"24 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140746284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-26DOI: 10.2174/0124054615292315240318062929
Isaac O. Amao, Abiola O. Okesola, T. O. Ajiboye, Victor O. Animasahun, Hannah O. Dada-Adegbola
Antibiotic resistance among pathogens has grown to be a major concern for the health of people around the world. One of the main subgroups of troublesome multidrugresistant bacteria that has recently undergone rapid evolution is Methicillin-resistant Staphylococcus aureus (MRSA). In this study, silver nanoparticles were synthesized using an aqueous extract of Bridelia feeruginea leaves. The methicillin-resistant S. aureus was used to test the antibacterial properties of the produced Bridelia ferruginea-derived silver nanoparticles. These nanoparticles were characterized using XRD, UV-vis spectroscopy, FTIR, and SEM. The antibacterial activity of the silver nanoparticles was improved at doses of 50, 100, and 150 ug/ml, with mean zones of inhibition (ZOI) of 13.0, 16.4, and 17.4 mm (SD1). When combined with erythromycin medicines, silver nanoparticles showed significant antibacterial efficiency compared to when used alone. The ZOI was 23 mm at 150 ug/mL, compared to 21 mm at 50 and 100 ug/mL. At P=0.06, the outcomes were statistically significant. This established that the antibacterial impact of combining antibiotics with AgNPs is enhanced. The current work showed that biosynthesized B. ferruginea silver nanoparticles (BFAgNPs) were effective in vitro.
{"title":"Antimicrobial Potency of the Biosynthesized Silver Nanoparticles (AgNPs)\u0000on Methicillin-Resistant Staphylococcus aureus (MRSA) Using Bridelia\u0000ferruginea Benth Plant Extract","authors":"Isaac O. Amao, Abiola O. Okesola, T. O. Ajiboye, Victor O. Animasahun, Hannah O. Dada-Adegbola","doi":"10.2174/0124054615292315240318062929","DOIUrl":"https://doi.org/10.2174/0124054615292315240318062929","url":null,"abstract":"\u0000\u0000Antibiotic resistance among pathogens has grown to be a major concern\u0000for the health of people around the world. One of the main subgroups of troublesome multidrugresistant\u0000bacteria that has recently undergone rapid evolution is Methicillin-resistant Staphylococcus\u0000aureus (MRSA).\u0000\u0000\u0000\u0000In this study, silver nanoparticles were synthesized using an aqueous extract of Bridelia\u0000feeruginea leaves. The methicillin-resistant S. aureus was used to test the antibacterial properties of\u0000the produced Bridelia ferruginea-derived silver nanoparticles. These nanoparticles were characterized\u0000using XRD, UV-vis spectroscopy, FTIR, and SEM.\u0000\u0000\u0000\u0000The antibacterial activity of the silver nanoparticles was improved at doses of 50, 100, and\u0000150 ug/ml, with mean zones of inhibition (ZOI) of 13.0, 16.4, and 17.4 mm (SD1). When combined\u0000with erythromycin medicines, silver nanoparticles showed significant antibacterial efficiency compared\u0000to when used alone. The ZOI was 23 mm at 150 ug/mL, compared to 21 mm at 50 and 100\u0000ug/mL. At P=0.06, the outcomes were statistically significant.\u0000\u0000\u0000\u0000This established that the antibacterial impact of combining antibiotics with AgNPs is\u0000enhanced. The current work showed that biosynthesized B. ferruginea silver nanoparticles (BFAgNPs)\u0000were effective in vitro.\u0000","PeriodicalId":10924,"journal":{"name":"Current Nanomaterials","volume":"114 33","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140380021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-22DOI: 10.2174/0124054615292106240213064923
Amruth B A, Kushala C, Vaibhavi J G, Rashmi V, Sanjay K R
In today’s world, nanoparticles play a pivotal role in revolutionizing many industries. Their nano size enables novel applications that have the potential to address pressing global challenges. The paper reviews the major properties and their practical implementations of Zinc Oxide Nanoparticles (ZnO NPs). Different methods of ZnO NP synthesis produced a surface area ranging from 57m2g-1 to 83m2g-1. A precipitation and green synthesis of ZnO NPs demonstrated its catalytic behavior. ZnOx doped with MnCO3 showed the highest catalytic activity. These properties have applications in wastewater treatment and dye removal processes in textile industries. ZnO NPs exhibit UV shielding and photocatalytic properties. ZnO NPs-coated cotton fabric is used in textile industries as it has more UV protection against uncoated cotton fabric. ZnO NPs are major semiconductors having a band gap of 3.34eV. This gives a range of applications in electrical and electronic industries. Biologically synthesized ZnO NP had better anti-microbial properties, which have a wide range of applications in the food industry, compared to chemically synthesized ZnO NP. The anti-cancer properties of ZnO NPs are due to their cytotoxicity making it a potential drug against cancer cells.
{"title":"A Mini-review on Properties and Applications of Zinc Oxide Nanoparticles","authors":"Amruth B A, Kushala C, Vaibhavi J G, Rashmi V, Sanjay K R","doi":"10.2174/0124054615292106240213064923","DOIUrl":"https://doi.org/10.2174/0124054615292106240213064923","url":null,"abstract":"\u0000\u0000In today’s world, nanoparticles play a pivotal role in revolutionizing many industries.\u0000Their nano size enables novel applications that have the potential to address pressing global challenges.\u0000The paper reviews the major properties and their practical implementations of Zinc Oxide\u0000Nanoparticles (ZnO NPs). Different methods of ZnO NP synthesis produced a surface area ranging\u0000from 57m2g-1 to 83m2g-1. A precipitation and green synthesis of ZnO NPs demonstrated its catalytic\u0000behavior. ZnOx doped with MnCO3 showed the highest catalytic activity. These properties have\u0000applications in wastewater treatment and dye removal processes in textile industries. ZnO NPs exhibit\u0000UV shielding and photocatalytic properties. ZnO NPs-coated cotton fabric is used in textile\u0000industries as it has more UV protection against uncoated cotton fabric. ZnO NPs are major semiconductors\u0000having a band gap of 3.34eV. This gives a range of applications in electrical and electronic\u0000industries. Biologically synthesized ZnO NP had better anti-microbial properties, which have\u0000a wide range of applications in the food industry, compared to chemically synthesized ZnO NP. The\u0000anti-cancer properties of ZnO NPs are due to their cytotoxicity making it a potential drug against\u0000cancer cells.\u0000","PeriodicalId":10924,"journal":{"name":"Current Nanomaterials","volume":"21 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140442122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-19DOI: 10.2174/0124054615269089240202043246
Yogesh Kumar, Astha Sharma, Prachi Varshney, Devdhar Yadav, Amit Singh, Naga Rani Kagithala, Pramod Sharma, Omji Porwal, Neeraj Kumar, Pradeep Kumar Sharma, Ashok Kumar Gupta, K. G
The two-dimensional structure of graphene has a flat single layer of carbon molecules having a honeycomb crystal lattice configuration. Graphene possesses typical physicochemical characteristics such as elevated conductivity, wide-ranging surface area, good biocompatibility, and excellent mechanical properties. Due to their exceptional properties, graphene derivatives have significant implementations in many fields like electronics, environmental, chemical, pharmaceutical, and others. With its distinctive formation and biological characteristics, pharmaceutical and biomedical applications of graphene have gained the impressive interest of researchers and scientists over the past few years. The exceptional properties of graphene, such as its larger surface area, which is four times greater than other nanoparticles, represented it as a prior choice for drug delivery. Graphene derivatives are monolayer graphene, bilayer graphene, reduced Graphene Oxide (rGO), and Graphene Oxide (GO). This review focused on different pharmaceutical applications and the part of the progress made by different researchers on graphene and its derivatives in the distinct field of interest, like in the delivery of drugs, cancer therapy, gene delivery, antibacterial effect, biosensing, bioimaging, tissue engineering, and others.
{"title":"lkGraphene Nano-Derivatives in Pharmaceuticals and Biomedical Advancements: A Comprehensive Review","authors":"Yogesh Kumar, Astha Sharma, Prachi Varshney, Devdhar Yadav, Amit Singh, Naga Rani Kagithala, Pramod Sharma, Omji Porwal, Neeraj Kumar, Pradeep Kumar Sharma, Ashok Kumar Gupta, K. G","doi":"10.2174/0124054615269089240202043246","DOIUrl":"https://doi.org/10.2174/0124054615269089240202043246","url":null,"abstract":"\u0000\u0000The two-dimensional structure of graphene has a flat single layer of carbon molecules\u0000having a honeycomb crystal lattice configuration. Graphene possesses typical physicochemical\u0000characteristics such as elevated conductivity, wide-ranging surface area, good biocompatibility,\u0000and excellent mechanical properties. Due to their exceptional properties, graphene derivatives have\u0000significant implementations in many fields like electronics, environmental, chemical, pharmaceutical,\u0000and others. With its distinctive formation and biological characteristics, pharmaceutical and\u0000biomedical applications of graphene have gained the impressive interest of researchers and scientists\u0000over the past few years. The exceptional properties of graphene, such as its larger surface area,\u0000which is four times greater than other nanoparticles, represented it as a prior choice for drug delivery.\u0000Graphene derivatives are monolayer graphene, bilayer graphene, reduced Graphene Oxide\u0000(rGO), and Graphene Oxide (GO). This review focused on different pharmaceutical applications\u0000and the part of the progress made by different researchers on graphene and its derivatives in the\u0000distinct field of interest, like in the delivery of drugs, cancer therapy, gene delivery, antibacterial\u0000effect, biosensing, bioimaging, tissue engineering, and others.\u0000","PeriodicalId":10924,"journal":{"name":"Current Nanomaterials","volume":"88 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140449358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Excipients are increasingly employed in novel dosage forms to accomplish specialized roles, and they also directly or indirectly alter the extent and rate of drug release and absorption. The trend toward using plant-based and natural goods has raised demand and, in some ways, replaced synthetic additives with natural ones. Natural and semisynthetic materials offer various advantages over synthetic materials since they are chemically inert, less toxic, less expensive, biodegradable, increase product shelf life, and are widely accessible. This review aims to cover the natural excipients’ role in nanoformulations and associated prospects. More than 500 manuscripts were collected from ScienceDirect, PubMed, google, and other sources; however the manuscripts were excluded based on their relevance to the subject and finally 80 manuscripts were analyzed for the data. The substation of synthetic lipids with natural and semisynthetic for developing lipid-based nano drug delivery, and the use of gelatin and chitosan in developing encapsulated and nano particulates are a few examples to understand the above-mentioned transition. This review provides an overview of the types of excipients used in the formulation of novel drug delivery systems with special emphasis on their characteristics, safety aspects, benefits associated, and common methods through, which they are employed in nanoformulations.
{"title":"Natural Excipients: Role in Nano Drug Delivery System","authors":"Pranita Jirwankar, Surendra Agrawal, Fuzail Shaikh, Kadambari Borse","doi":"10.2174/0124054615248522231211105002","DOIUrl":"https://doi.org/10.2174/0124054615248522231211105002","url":null,"abstract":"\u0000\u0000Excipients are increasingly employed in novel dosage forms to accomplish\u0000specialized roles, and they also directly or indirectly alter the extent and rate of drug release and\u0000absorption. The trend toward using plant-based and natural goods has raised demand and, in some\u0000ways, replaced synthetic additives with natural ones. Natural and semisynthetic materials offer various\u0000advantages over synthetic materials since they are chemically inert, less toxic, less expensive,\u0000biodegradable, increase product shelf life, and are widely accessible.\u0000\u0000\u0000\u0000This review aims to cover the natural excipients’ role in nanoformulations and associated\u0000prospects.\u0000\u0000\u0000\u0000More than 500 manuscripts were collected from ScienceDirect, PubMed, google, and\u0000other sources; however the manuscripts were excluded based on their relevance to the subject and\u0000finally 80 manuscripts were analyzed for the data.\u0000\u0000\u0000\u0000The substation of synthetic lipids with natural and semisynthetic for developing lipid-based\u0000nano drug delivery, and the use of gelatin and chitosan in developing encapsulated and nano particulates\u0000are a few examples to understand the above-mentioned transition.\u0000\u0000\u0000\u0000This review provides an overview of the types of excipients used in the formulation of\u0000novel drug delivery systems with special emphasis on their characteristics, safety aspects, benefits\u0000associated, and common methods through, which they are employed in nanoformulations.\u0000","PeriodicalId":10924,"journal":{"name":"Current Nanomaterials","volume":" 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138961419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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