Pub Date : 2023-09-05DOI: 10.2174/2405461508666230905115443
Kirubel Teshome Tadele, G. Muleta, Mulatu D. Firisa
Fabrication of nanoparticles (NPs) by the biological approach has gained extensive attention recently due to its low cost, simplicity, non-toxic and environmentally-friendly nature, as compared to the toxic as well as expensive chemical and physical methods. This study aimed to synthesize ZnO and Cu-doped ZnO NPs using Aloe vera leaf extract for their photocatalytic and antibacterial activities evaluation. ZnO and Cu-doped ZnO NPs were synthesized using Aloe vera extract by optimizing the reaction parameters, including precursor salt concentration, plant extract volume, and solution pH. The as-synthesized nanoproducts were characterized using FT-IR, UV-Vis, SEM, and XRD spectroscopic techniques, and tested as antibacterial agents and photocatalysts. The XRD pattern data indicated all the synthesized NPs to have a crystallite nature with a particle size of 19.24 nm, 23.74 nm, and 24.91 nm for ZnO, 1% Cu-doped ZnO, and 4% Cu-doped ZnO NPs, respectively. SEM image revealed crushed-ice, irregular, and spherical shapes of the NPs. The synthesized nanoproducts displayed good antibacterial activity, and the best potential was observed against gram-positive bacteria (B. cereus and S. aureus) of 4% Cu-doped ZnO NPs, followed by 1% Cu-doped ZnO NPs, with the reference to the selected standards gentamicin and DMSO, while the least inhibition zone was seen against gram-negative bacteria (E. coli and S. typhi). 1% Cu-doped ZnO and 4% Cu-doped ZnO displayed good photocatalytic potential at 78.48% and 88.07%, respectively, after 180 min of irradiation, while 4% Cu-doped ZnO NPs displayed better degrading potential with effective reusability. The good antibacterial and photocatalytic activities of the synthesized Cu-doped ZnO NPs may lead to the application of the nanomaterials in antimicrobial and catalysis fields with the required modifications for enhancement of their potential.
{"title":"Synthesis of Cu-doped ZnO Nanoparticles Using Aloe vera Leaf Extract for Antibacterial and Photocatalytic Activities Evaluation","authors":"Kirubel Teshome Tadele, G. Muleta, Mulatu D. Firisa","doi":"10.2174/2405461508666230905115443","DOIUrl":"https://doi.org/10.2174/2405461508666230905115443","url":null,"abstract":"\u0000\u0000Fabrication of nanoparticles (NPs) by the biological approach has gained extensive attention recently due to its low cost, simplicity, non-toxic and environmentally-friendly nature, as compared to the toxic as well as expensive chemical and physical methods. This study aimed to synthesize ZnO and Cu-doped ZnO NPs using Aloe vera leaf extract for their photocatalytic and antibacterial activities evaluation.\u0000\u0000\u0000\u0000ZnO and Cu-doped ZnO NPs were synthesized using Aloe vera extract by optimizing the reaction parameters, including precursor salt concentration, plant extract volume, and solution pH. The as-synthesized nanoproducts were characterized using FT-IR, UV-Vis, SEM, and XRD spectroscopic techniques, and tested as antibacterial agents and photocatalysts.\u0000\u0000\u0000\u0000The XRD pattern data indicated all the synthesized NPs to have a crystallite nature with a particle size of 19.24 nm, 23.74 nm, and 24.91 nm for ZnO, 1% Cu-doped ZnO, and 4% Cu-doped ZnO NPs, respectively. SEM image revealed crushed-ice, irregular, and spherical shapes of the NPs. The synthesized nanoproducts displayed good antibacterial activity, and the best potential was observed against gram-positive bacteria (B. cereus and S. aureus) of 4% Cu-doped ZnO NPs, followed by 1% Cu-doped ZnO NPs, with the reference to the selected standards gentamicin and DMSO, while the least inhibition zone was seen against gram-negative bacteria (E. coli and S. typhi). 1% Cu-doped ZnO and 4% Cu-doped ZnO displayed good photocatalytic potential at 78.48% and 88.07%, respectively, after 180 min of irradiation, while 4% Cu-doped ZnO NPs displayed better degrading potential with effective reusability.\u0000\u0000\u0000\u0000The good antibacterial and photocatalytic activities of the synthesized Cu-doped ZnO NPs may lead to the application of the nanomaterials in antimicrobial and catalysis fields with the required modifications for enhancement of their potential.\u0000","PeriodicalId":10924,"journal":{"name":"Current Nanomaterials","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48089085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.2174/2405461508666230901123920
Christina V. Panagiotakopoulou, Panagiotis Papandreopoulos, G. Batis
the performance of nano modified cement based materials is substantial in terms of their mechanical durability and other similar properties that are of great importance in the functional life of cement structures. The motivation of this study is to formulate conclusions concerning the anti-corrosive impact of Carbon nanotubes (CNTs) and Carbon nanofibers (CNFs) on the properties of mortar specimens and respectively on their service life. The nano additives performance, was investigated through Scanning methods, such as X-ray diffraction (XRD), and Scanning Electron Microscopy (SEM) which analyze the microstructure of mortar specimens with 0.1 % wt addition of CNTs and 0.1 % wt addition of CNFs in their synthesis. In addition, other techniques such as total chloride content and gravimetric mass loss measurements, provide a consolidated assessment of the impact of the nano modified cement materials. In particular, (SEM) and (XRD) microstructure analysis results showed that nanoadditives are found as agglomerates in the cement paste, whereas their hydrophobic nature blocks the diffusion of corrosive factors into the cement paste. Additionally, the total chloride content in mortar specimens with CNFs is approximately 50% less than the relevant percentage of the specimens without additives, which is in compliance with the relevant percentages of porosity values. Furthermore, from the elemental analysis of all specimens, it is found that the samples that are corroded are the specimens without nano additives. The addition of nanomodified materials affects the porosity and the microstructure of the mortar specimens. The addition of 0,1 % of CNTs or CNFs positively affects against corrosion impact while exposure in extremely corrosive conditions.
{"title":"Investigation of Corrosion Protection Through CNTs/ CNFs Modified Cement Mortars","authors":"Christina V. Panagiotakopoulou, Panagiotis Papandreopoulos, G. Batis","doi":"10.2174/2405461508666230901123920","DOIUrl":"https://doi.org/10.2174/2405461508666230901123920","url":null,"abstract":"\u0000\u0000the performance of nano modified cement based materials is substantial in\u0000terms of their mechanical durability and other similar properties that are of great importance in the\u0000functional life of cement structures. The motivation of this study is to formulate conclusions concerning\u0000the anti-corrosive impact of Carbon nanotubes (CNTs) and Carbon nanofibers (CNFs) on the\u0000properties of mortar specimens and respectively on their service life.\u0000\u0000\u0000\u0000The nano additives performance, was investigated through Scanning methods, such as X-ray\u0000diffraction (XRD), and Scanning Electron Microscopy (SEM) which analyze the microstructure of\u0000mortar specimens with 0.1 % wt addition of CNTs and 0.1 % wt addition of CNFs in their synthesis.\u0000In addition, other techniques such as total chloride content and gravimetric mass loss measurements,\u0000provide a consolidated assessment of the impact of the nano modified cement materials. In particular,\u0000(SEM) and (XRD) microstructure analysis results showed that nanoadditives are found as agglomerates\u0000in the cement paste, whereas their hydrophobic nature blocks the diffusion of corrosive factors into\u0000the cement paste. Additionally, the total chloride content in mortar specimens with CNFs is approximately\u000050% less than the relevant percentage of the specimens without additives, which is in compliance\u0000with the relevant percentages of porosity values. Furthermore, from the elemental analysis of all\u0000specimens, it is found that the samples that are corroded are the specimens without nano additives.\u0000\u0000\u0000\u0000The addition of nanomodified materials affects the porosity and the microstructure of the\u0000mortar specimens.\u0000\u0000\u0000\u0000The addition of 0,1 % of CNTs or CNFs positively affects against corrosion impact while\u0000exposure in extremely corrosive conditions.\u0000","PeriodicalId":10924,"journal":{"name":"Current Nanomaterials","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48373713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.2174/240546150803230125113935
Demir Mustafa M.
{"title":"Meet the Editorial Board Member","authors":"Demir Mustafa M.","doi":"10.2174/240546150803230125113935","DOIUrl":"https://doi.org/10.2174/240546150803230125113935","url":null,"abstract":"","PeriodicalId":10924,"journal":{"name":"Current Nanomaterials","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135895733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-29DOI: 10.2174/2405461508666230829100138
Nikitha Shalom Richard
Titanium dioxide nanoparticles (TiO2 NPs) are formed in vast amounts worldwide for usage in several applications. They possess excellent photocatalytic properties, high chemical stability, and a wide bandgap, making them highly effective in environmental remediation and solar energy conversion. TiO2 nanoparticles exhibit biocompatibility, allowing their utilization in biomedical uses, such as molecular imaging, drug delivery, and tissue engineering. Chemical methods, such as hydrothermal, sol-gel, and chemical vapor deposition, provide versatility in controlling nanoparticle size, morphology, and crystallinity. They offer relatively lower production costs, scalability, and the ability to incorporate dopants or functionalize the nanoparticle surface. Their small size and large surface area-to-volume ratio enable enhanced reactivity and surface functionality, facilitating their incorporation into composite materials and surface coatings for improved performance. Regarding the potential toxicity of TiO2 nanoparticles, the bulk form of TiO2 is considered safe for human consumption, but the reduced size of nanoparticles raises concerns about their potential adverse effects. TiO2 nanoparticles strongly depend on factors, such as particle size, surface modifications, exposure route, and duration. Therefore, continued research is essential to gain a comprehensive understanding of the toxicity mechanisms and develop strategies to mitigate any potential adverse effects, ensuring the safe and responsible utilization of TiO2 nanoparticles in different fields.
{"title":"Potential and Harmful Effects of Titanium Dioxide Nanoparticle on Health: A Brief Note","authors":"Nikitha Shalom Richard","doi":"10.2174/2405461508666230829100138","DOIUrl":"https://doi.org/10.2174/2405461508666230829100138","url":null,"abstract":"\u0000\u0000Titanium dioxide nanoparticles (TiO2 NPs) are formed in vast amounts worldwide for usage in several applications. They possess excellent photocatalytic properties, high chemical stability, and a wide bandgap, making them highly effective in environmental remediation and solar energy conversion. TiO2 nanoparticles exhibit biocompatibility, allowing their utilization in biomedical uses, such as molecular imaging, drug delivery, and tissue engineering. Chemical methods, such as hydrothermal, sol-gel, and chemical vapor deposition, provide versatility in controlling nanoparticle size, morphology, and crystallinity. They offer relatively lower production costs, scalability, and the ability to incorporate dopants or functionalize the nanoparticle surface. Their small size and large surface area-to-volume ratio enable enhanced reactivity and surface functionality, facilitating their incorporation into composite materials and surface coatings for improved performance. Regarding the potential toxicity of TiO2 nanoparticles, the bulk form of TiO2 is considered safe for human consumption, but the reduced size of nanoparticles raises concerns about their potential adverse effects. TiO2 nanoparticles strongly depend on factors, such as particle size, surface modifications, exposure route, and duration. Therefore, continued research is essential to gain a comprehensive understanding of the toxicity mechanisms and develop strategies to mitigate any potential adverse effects, ensuring the safe and responsible utilization of TiO2 nanoparticles in different fields.\u0000","PeriodicalId":10924,"journal":{"name":"Current Nanomaterials","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48203871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-29DOI: 10.2174/2405461508666230829102228
S. Alamdari, Mohammad Mansourian, M. S. Ghamsari
In this study, a simple and facile route was employed to prepare a highly transparent and luminescent ultra-thin gallium doped ZnO film (GZO). The thin GZO film has been deposited using the simultaneously ultrasonic vibration and sol-gel spin-spray coating technique. The structural and optical properties of pure and doped thin films were investigated by various methods, such as X-ray diffraction (XRD), X-ray photoemission spectroscopy (XPS), scanning electron microscopy (SEM), UV-Vis, and PL spectroscopy. XRD results indicated that both pure and doped ZnO films had a hexagonal wurtzite structure with (101) preferred orientation. XPS and EDX studies confirmed the incorporation and presence of Ga ions into the ZnO lattice structure. The doped sample showed nearly 90% of transparency, and a strong blue-green emission in the visible region. The obtained results proved that the prepared thin film could be a novel candidate for optoelectronic applications.
{"title":"Thin Ga-doped ZnO Film with Enhanced Dual Visible Lines Emission","authors":"S. Alamdari, Mohammad Mansourian, M. S. Ghamsari","doi":"10.2174/2405461508666230829102228","DOIUrl":"https://doi.org/10.2174/2405461508666230829102228","url":null,"abstract":"\u0000\u0000In this study, a simple and facile route was employed to prepare a highly transparent and luminescent ultra-thin gallium doped ZnO film (GZO).\u0000\u0000\u0000\u0000The thin GZO film has been deposited using the simultaneously ultrasonic vibration and sol-gel spin-spray coating technique. The structural and optical properties of pure and doped thin films were investigated by various methods, such as X-ray diffraction (XRD), X-ray photoemission spectroscopy (XPS), scanning electron microscopy (SEM), UV-Vis, and PL spectroscopy.\u0000\u0000\u0000\u0000XRD results indicated that both pure and doped ZnO films had a hexagonal wurtzite structure with (101) preferred orientation. XPS and EDX studies confirmed the incorporation and presence of Ga ions into the ZnO lattice structure. The doped sample showed nearly 90% of transparency, and a strong blue-green emission in the visible region.\u0000\u0000\u0000\u0000The obtained results proved that the prepared thin film could be a novel candidate for optoelectronic applications.\u0000","PeriodicalId":10924,"journal":{"name":"Current Nanomaterials","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48828314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-17DOI: 10.2174/2405461508666230817101938
Mallika Tamminana, B. Ravikumar
Nilotinib is a BCS class-IV poorly water-soluble kinase inhibitor drug, that was used for this study to prepare the polymeric nanoparticles by nanoprecipitation technique using Eudragit RL-100 and RS-100 as polymers, Killophore P-188 as a surfactant, and PEG 400 used as a non-volatile, and nontoxic solvent for the improvement of the drug solubility and dissolution rate. The initial process and formulation variables are screened out based on the selected critical quality attributes such as drug release (%), particle size (nm), zeta potential (mV), and polydispersity index. The FT-IR and DSC studies reveal that the drug has no compatibility between the selected drug and the polymers and does not show any additional drug peaks after physical mixing and formulations. The prepared nanoparticles were further characterized to evaluate the particle size (nm), polydispersity index (PDI), zeta potential (mV), entrapment efficiency (%), and in-vitro drug release (%). From the in vitro drug release study, Eudragit RL-100 and Killophore P-188-based formulations showed optimum drug entrapment efficiency with improved drug solubility and dissolution rate in PEG 400 compared to Eudragit RS-100-based formulations. The accelerated stability data for the optimized formulation batch (F6) before and after storage conditions at 40±2 0 C and 75±5% RH indicates that the optimized formulation (F6) is more stable for up to 6 months without changes in drug entrapment efficiency and in vitro dissolution rate. Dissolution kinetic data and diffusion exponent values suggested that optimized formulation followed the Higuchi model with a non-Fickian transport mechanism. According to the results, the preparation method proposed in this study is the most suitable for generating polymeric nanoparticles of nilotinib for improved drug solubility and dissolution rate. The nilotinib-based polymeric nano-formulation proved a potential alternative for better drug release with an enhanced solubility rate.
{"title":"Formulation Design and Characterization of Nilotinib Polymeric Nanoparticles by Nanoprecipitation Technique for the Improved Drug Solubility and Dissolution Rate","authors":"Mallika Tamminana, B. Ravikumar","doi":"10.2174/2405461508666230817101938","DOIUrl":"https://doi.org/10.2174/2405461508666230817101938","url":null,"abstract":"\u0000\u0000Nilotinib is a BCS class-IV poorly water-soluble kinase inhibitor drug, that\u0000was used for this study to prepare the polymeric nanoparticles by nanoprecipitation technique using\u0000Eudragit RL-100 and RS-100 as polymers, Killophore P-188 as a surfactant, and PEG 400 used as a\u0000non-volatile, and nontoxic solvent for the improvement of the drug solubility and dissolution rate.\u0000\u0000\u0000\u0000The initial process and formulation variables are screened out based on the selected critical\u0000quality attributes such as drug release (%), particle size (nm), zeta potential (mV), and polydispersity\u0000index. The FT-IR and DSC studies reveal that the drug has no compatibility between the selected drug\u0000and the polymers and does not show any additional drug peaks after physical mixing and formulations.\u0000The prepared nanoparticles were further characterized to evaluate the particle size (nm), polydispersity\u0000index (PDI), zeta potential (mV), entrapment efficiency (%), and in-vitro drug release (%). From the\u0000in vitro drug release study, Eudragit RL-100 and Killophore P-188-based formulations showed optimum drug entrapment efficiency with improved drug solubility and dissolution rate in PEG 400 compared to Eudragit RS-100-based formulations. The accelerated stability data for the optimized formulation batch (F6) before and after storage conditions at 40±2 0\u0000C and 75±5% RH indicates that the optimized formulation (F6) is more stable for up to 6 months without changes in drug entrapment efficiency and in vitro dissolution rate. Dissolution kinetic data and diffusion exponent values suggested\u0000that optimized formulation followed the Higuchi model with a non-Fickian transport mechanism.\u0000\u0000\u0000\u0000According to the results, the preparation method proposed in this study is the most suitable for\u0000generating polymeric nanoparticles of nilotinib for improved drug solubility and dissolution rate.\u0000\u0000\u0000\u0000The nilotinib-based polymeric nano-formulation proved a potential alternative for better\u0000drug release with an enhanced solubility rate.\u0000","PeriodicalId":10924,"journal":{"name":"Current Nanomaterials","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41662912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-16DOI: 10.2174/2405461508666230816090519
Celso Sant’Anna, Veronica da Silva Ferreira, Mateus Ferreira Conz Eugenio, Elaine Del Nery, Wanderley De Souza
background: Breast cancer being the most common among women. Due to the resistance to antitumor treatments, alternative treatments have been sought, as metallic nanoparticles objective: This study aimed to evaluate the antitumor potential and cytotoxicity induction mechanisms of green synthesized AgCl-NPs and Ag/AgCl-NPs. method: The antitumor potential of nanoparticles was evaluated in breast cancer BT-474 and MDA-MB-436 cell lines treated with 0-40 μg/mL AgCl-NPs or 0-12.5 μg/mL Ag/AgCl-NPs through image-based high content analysis method. Normal human retinal pigment epithelial 1 (RPE-1) cells were used for comparison. result: The growth rate of the RPE-1 cells treated with nanoparticles was little affected, and no significant changes in cell viability were observed. In these cells, the nanoparticle treatments did not induce lysosomal damage, changes in ROS production or reduction in the mitochondrial membrane potential. The level of BT-474 and MDA-MB-436 cell proliferation was markedly decreased, and cell viability was reduced by 64.19 and 46.19 conclusion: Together, the results show overall cytotoxic effects of both AgCl-NPs and Ag/AgCl-NPs towards breast cancer cells with negligible effects against healthy cells, which suggests their promising anticancer and biomedical applications.
{"title":"Quantitative characterization of the effect of biogenic silver-based nanoparticles on breast cancer cells by high content analysis","authors":"Celso Sant’Anna, Veronica da Silva Ferreira, Mateus Ferreira Conz Eugenio, Elaine Del Nery, Wanderley De Souza","doi":"10.2174/2405461508666230816090519","DOIUrl":"https://doi.org/10.2174/2405461508666230816090519","url":null,"abstract":"background: Breast cancer being the most common among women. Due to the resistance to antitumor treatments, alternative treatments have been sought, as metallic nanoparticles objective: This study aimed to evaluate the antitumor potential and cytotoxicity induction mechanisms of green synthesized AgCl-NPs and Ag/AgCl-NPs. method: The antitumor potential of nanoparticles was evaluated in breast cancer BT-474 and MDA-MB-436 cell lines treated with 0-40 μg/mL AgCl-NPs or 0-12.5 μg/mL Ag/AgCl-NPs through image-based high content analysis method. Normal human retinal pigment epithelial 1 (RPE-1) cells were used for comparison. result: The growth rate of the RPE-1 cells treated with nanoparticles was little affected, and no significant changes in cell viability were observed. In these cells, the nanoparticle treatments did not induce lysosomal damage, changes in ROS production or reduction in the mitochondrial membrane potential. The level of BT-474 and MDA-MB-436 cell proliferation was markedly decreased, and cell viability was reduced by 64.19 and 46.19 conclusion: Together, the results show overall cytotoxic effects of both AgCl-NPs and Ag/AgCl-NPs towards breast cancer cells with negligible effects against healthy cells, which suggests their promising anticancer and biomedical applications.","PeriodicalId":10924,"journal":{"name":"Current Nanomaterials","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136392197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-16DOI: 10.2174/2405461508666230816141752
Boga Vijay Kumar, G. S. Asthana, Abhay Asthana, Gaddam Rakesh
For centuries, silver has been known for its anti-bacterial effects. It also helps in the prevention and control of various infections. Silver, when synthesized in nano-size, is much more effective, so the trend of using silver nanoparticles in treating mild bacterial diseases to deadly infectious diseases has increased rapidly. Silver nanoparticles can be synthesized by physical, chemical, and biological methods. Nanoparticles are developed in different shapes and have a wide range of sizes, with the purpose of controlling the release rate and content of the drug’s dose. The nanoparticles can be administered via oral, pulmonary, dermal, and intravenous routes. Silver nanoparticles have been used in treating diseases, such as cancers, diabetes, etc., by targeted drug delivery and in cosmetics, wound healing, diagnostics, water purifying, bio-imaging, air purification, etc. The research on the novel applications of silver nanoparticles merits its medical application, and this utility aspect is granting patented technologies. The utilization of silver nanoparticles has enhanced in recent times due to their effectiveness in the specified diseased state. Studies have indicated that the drugs developed using silver nanoparticles manifest safety as they are biocompatible; thus, silver nanoparticles display a promising role in developing futuristic medical therapeutic strategies.
{"title":"Silver Nanoparticle Carriers: A Significant Development in Nanotechnology","authors":"Boga Vijay Kumar, G. S. Asthana, Abhay Asthana, Gaddam Rakesh","doi":"10.2174/2405461508666230816141752","DOIUrl":"https://doi.org/10.2174/2405461508666230816141752","url":null,"abstract":"\u0000\u0000For centuries, silver has been known for its anti-bacterial effects. It also helps in\u0000the prevention and control of various infections. Silver, when synthesized in nano-size, is much more effective,\u0000so the trend of using silver nanoparticles in treating mild bacterial diseases to deadly infectious\u0000diseases has increased rapidly.\u0000\u0000\u0000\u0000Silver nanoparticles can be synthesized by physical, chemical, and biological methods. Nanoparticles\u0000are developed in different shapes and have a wide range of sizes, with the purpose of controlling\u0000the release rate and content of the drug’s dose. The nanoparticles can be administered via oral,\u0000pulmonary, dermal, and intravenous routes.\u0000\u0000\u0000\u0000Silver nanoparticles have been used in treating diseases, such as cancers, diabetes, etc., by\u0000targeted drug delivery and in cosmetics, wound healing, diagnostics, water purifying, bio-imaging, air\u0000purification, etc. The research on the novel applications of silver nanoparticles merits its medical application,\u0000and this utility aspect is granting patented technologies. The utilization of silver nanoparticles has\u0000enhanced in recent times due to their effectiveness in the specified diseased state.\u0000\u0000\u0000\u0000Studies have indicated that the drugs developed using silver nanoparticles manifest safety\u0000as they are biocompatible; thus, silver nanoparticles display a promising role in developing futuristic\u0000medical therapeutic strategies.\u0000","PeriodicalId":10924,"journal":{"name":"Current Nanomaterials","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41348766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-09DOI: 10.2174/2405461508666230809151727
K. Girigoswami, Keerthana Vedhantham, S. Metkar, A. Girigoswami
In the past decades, it has been evident that nano miniaturization technology plays a vital role in innovations, biomedical and industrial applications. Most importantly, the use of Lab on chip (LOC) is revolutionizing and highly replacing the use of conventional technologies due to its advantages that include reliability, biocompatibility, tunability, portability, controllability, cost-effective, low time, and energy consumption with more accurate results. The different nucleic acid structures formed by non-classical ways of pairing can result in highly stable structures, known as nano-oddities. These nucleic acid nano-oddities could be fabricated for a wide range of applications with unique properties. This review encompasses the major findings, advances, fabrication, miniaturization, applications, and the future prospects of nucleic acid assemblies in different kinds of nanodevices.
{"title":"Miniaturization of Nucleic Acid Assemblies in Nanodevice: Nano-Oddities","authors":"K. Girigoswami, Keerthana Vedhantham, S. Metkar, A. Girigoswami","doi":"10.2174/2405461508666230809151727","DOIUrl":"https://doi.org/10.2174/2405461508666230809151727","url":null,"abstract":"\u0000\u0000In the past decades, it has been evident that nano miniaturization technology plays a vital\u0000role in innovations, biomedical and industrial applications. Most importantly, the use of Lab on chip\u0000(LOC) is revolutionizing and highly replacing the use of conventional technologies due to its advantages that include reliability, biocompatibility, tunability, portability, controllability, cost-effective,\u0000low time, and energy consumption with more accurate results. The different nucleic acid structures\u0000formed by non-classical ways of pairing can result in highly stable structures, known as nano-oddities.\u0000These nucleic acid nano-oddities could be fabricated for a wide range of applications with unique\u0000properties. This review encompasses the major findings, advances, fabrication, miniaturization, applications, and the future prospects of nucleic acid assemblies in different kinds of nanodevices.\u0000","PeriodicalId":10924,"journal":{"name":"Current Nanomaterials","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44599371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-04DOI: 10.2174/2405461508666230804103023
Nimisha Srivastava, Devashish Jena, M. Yasir, Deblina Dan
In the present scenario, various novel delivery systems are available for drug delivery to systemic circulation. So, to accomplish a greater therapeutic effect, the nature of the drug delivery is very important. This delivery is one of the innovative approaches where the drug is targeted to the brain through the nasal cavity. As we know, the human brain is the most crucial part of the body that controls various functions of our system. So, safely reaching the targeted site of the brain is necessary to achieve brain specificity. This delivery system helps us to tackle the problems that may arise in the other delivery system and helps the drug reach the brain without any difficulties. The major obstacles we faced during this delivery were the blood-brain barrier (BBB) and the brain-cerebrospinal fluid barrier. So, if we target the drug to the brain, then we have to overcome these challenges, and before that, we must have a clear understanding of the targeted site and the mechanism behind the drug targeting. Advancements in science and technology have helped discover many recent strategies and formulations available for intranasal delivery. The development of lipid nanoparticles is one of the primitive approaches for targeting any type of drug(hydrophilic/lipophilic) in the brain. So, the aim of this review mainly focused on the mechanism of intranasal delivery, the devices used, and some recent strategies like the development of lipid nanoparticles, surface-modified lipid nanocarriers, and nose-to-brain patches. This review article also includes a few FDA-approved formulations for nose-to-brain delivery and their regulatory aspects related to clinical trials and future perspectives.
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