Pub Date : 2022-02-21DOI: 10.2174/2405461507666220221094925
Binita Palaria, V. Tiwari, A. Tiwari, Ramsa Aslam, Ashok Kumar, B. Sahoo, Manish Kumar, Sunil Singh, Suresh Kumar
Nanostructured lipid carriers (NLCs) are considered second-generation lipid-based pharmaceutical formulations in drug delivery systems. It is a more efficient drug delivery system that includes the development of nano-particulate system and its superiority over the conventional drug delivery system. Among all available nanoparticles, NLC has gained more attention due to its superior characteristics such as lipophilic, biodegradable and biocompatible. This lipid nanoparticulate system is more advantageous over liposomes, microparticles, emulsions and solid lipid nanoparticles. NLCs have emerged as a promising carrier for the delivery of targeted drug substances via oral, parenteral, topical, pulmonary, transdermal and ocular routes. These nanocarriers are utilized for the delivery of both lipophilic as well as hydrophilic drugs. NLCs are composed of a matrix of physiological lipids i.e. solid lipid and liquid lipid, emulsifiers and water. NLCs provide an opportunity for large scale production, ease of preparation with enhanced encapsulation, targeted efficiency and reduced toxic effects. This review is focused on the advantages, limitations, methods of preparation, characterization and applications of NLCs.
{"title":"Nanostructured Lipid Carriers: A Promising Carrier in Targeted Drug Delivery System","authors":"Binita Palaria, V. Tiwari, A. Tiwari, Ramsa Aslam, Ashok Kumar, B. Sahoo, Manish Kumar, Sunil Singh, Suresh Kumar","doi":"10.2174/2405461507666220221094925","DOIUrl":"https://doi.org/10.2174/2405461507666220221094925","url":null,"abstract":"\u0000\u0000Nanostructured lipid carriers (NLCs) are considered second-generation lipid-based pharmaceutical formulations in drug delivery systems. It is a more efficient drug delivery system that includes the development of nano-particulate system and its superiority over the conventional drug delivery system. Among all available nanoparticles, NLC has gained more attention due to its superior characteristics such as lipophilic, biodegradable and biocompatible. This lipid nanoparticulate system is more advantageous over liposomes, microparticles, emulsions and solid lipid nanoparticles. NLCs have emerged as a promising carrier for the delivery of targeted drug substances via oral, parenteral, topical, pulmonary, transdermal and ocular routes. These nanocarriers are utilized for the delivery of both lipophilic as well as hydrophilic drugs. NLCs are composed of a matrix of physiological lipids i.e. solid lipid and liquid lipid, emulsifiers and water. NLCs provide an opportunity for large scale production, ease of preparation with enhanced encapsulation, targeted efficiency and reduced toxic effects. This review is focused on the advantages, limitations, methods of preparation, characterization and applications of NLCs.\u0000","PeriodicalId":10924,"journal":{"name":"Current Nanomaterials","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45225582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-02-04DOI: 10.2174/2405461507666220204100719
M. Mansourian, Sayed Mehdi Peimanimotlagh, M. Ghaedi, M. Talebianpoor, Z. Salehpour, Ghasem Ghalamfarsa, M. T. Ardakani, H. Bardania
Background: Treatment used for cancer are generally associated with serious side effects. New solutions for cancer therapy can overcome the shortcomings and problems of conventional therapies by designing drug delivery nanosystems. Methods: In this study, magnetic Fe3O4@AU@Albumin core-shell-shell (CSS) nanoparticles were synthesized and characterized by various analyses such as transmission electron microscopy (TEM), X-ray diffraction (XRD) and vibrating sample magnetization (VSM). Podophyllotoxin (PPT) was then loaded on magnetic nanoparticles as an anti-cancer drug and its effect on HT-29 and MCF-7 cell lines was evaluated using MTT assay. Result: The crystallinity of synthesized Fe3O4 magnetic nanoparticles was confirmed by XRD analysis. Next, a layer of gold was coated the Fe3O4 MNPs. The UV-Vis analysis of core-shell nanoparticles (iron oxide/gold)confirm the successful synthesis of these nanoparticles. The surface of the core-shell nanoparticles was then coated with albumin to load the drug. TEM image confirmed the existence of albumin nanoparticles loaded with core-shell magnetic nanoparticles. VSM analysis revealed that iron oxide, Fe3O4@AU, and Fe3O4@AU@Albumin nanoparticles have the highest magnetic properties, respectively. After synthesis of PPT loaded into MNP, the loading efficiency was 50%. The IC50 values of PPT alone and loaded into nanoparticles on MCF-7 cells after 24 hours were 3085.75 and 1868.09 nM, respectively, which were significantly toxic (P-value≤0.05) but not significant after 48 hours. The cytotoxicity of PPT loaded on nanoparticles was significantly more toxic to HT-29 cells after 24 and 48 h than PPT alone (P-value≤0.05). Conclusion: The anticancer drug of PPT-loaded MNPs has significant advantages over PPT alone due to its improved properties with appropriate cytotoxic activity. Thus, the PPT-loaded MNPs may be considered as effective anti-cancer agents for further research on drug development.
{"title":"Cytotoxic Effect of Podophyllotoxin-Loaded Magnetic Nanoparticles on Proliferation of Colorectal (HT-29) and Breast (MCF-7) Cancer Cell Lines","authors":"M. Mansourian, Sayed Mehdi Peimanimotlagh, M. Ghaedi, M. Talebianpoor, Z. Salehpour, Ghasem Ghalamfarsa, M. T. Ardakani, H. Bardania","doi":"10.2174/2405461507666220204100719","DOIUrl":"https://doi.org/10.2174/2405461507666220204100719","url":null,"abstract":"\u0000\u0000Background: Treatment used for cancer are generally associated with serious side effects. New solutions for cancer therapy can overcome the shortcomings and problems of conventional therapies by designing drug delivery nanosystems.\u0000\u0000\u0000\u0000Methods: In this study, magnetic Fe3O4@AU@Albumin core-shell-shell (CSS) nanoparticles were synthesized and characterized by various analyses such as transmission electron microscopy (TEM), X-ray diffraction (XRD) and vibrating sample magnetization (VSM). Podophyllotoxin (PPT) was then loaded on magnetic nanoparticles as an anti-cancer drug and its effect on HT-29 and MCF-7 cell lines was evaluated using MTT assay.\u0000\u0000\u0000\u0000Result: The crystallinity of synthesized Fe3O4 magnetic nanoparticles was confirmed by XRD analysis. Next, a layer of gold was coated the Fe3O4 MNPs. The UV-Vis analysis of core-shell nanoparticles (iron oxide/gold)confirm the successful synthesis of these nanoparticles. The surface of the core-shell nanoparticles was then coated with albumin to load the drug. TEM image confirmed the existence of albumin nanoparticles loaded with core-shell magnetic nanoparticles. \u0000VSM analysis revealed that iron oxide, Fe3O4@AU, and Fe3O4@AU@Albumin nanoparticles have the highest magnetic properties, respectively. After synthesis of PPT loaded into MNP, the loading efficiency was 50%. The IC50 values of PPT alone and loaded into nanoparticles on MCF-7 cells after 24 hours were 3085.75 and 1868.09 nM, respectively, which were significantly toxic (P-value≤0.05) but not significant after 48 hours. The cytotoxicity of PPT loaded on nanoparticles was significantly more toxic to HT-29 cells after 24 and 48 h than PPT alone (P-value≤0.05).\u0000\u0000\u0000\u0000Conclusion: The anticancer drug of PPT-loaded MNPs has significant advantages over PPT alone due to its improved properties with appropriate cytotoxic activity. Thus, the PPT-loaded MNPs may be considered as effective anti-cancer agents for further research on drug development.\u0000","PeriodicalId":10924,"journal":{"name":"Current Nanomaterials","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42318760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-31DOI: 10.2174/2405461507666220131104843
Deepika Sharma, Ghanshyam Teli, Komal Gupta, G. Bansal, G. Gupta, P. Chawla
Nanotechnology is thriving these days and plays a great role in the expansion of biosensors. A range of nanomaterials are used in the growth of biosensors in order to boost the performance and sensitivity of biosensors. Nanomaterials like nanowire, nanoparticles, carbon nanotubes, quantum dots etc. are helpful for increasing different properties like enzyme loading capacity, bioanalyte loading, good absorption as well as immobilization of enzymes. The skill of nanobiosensors becomes extra accurate and reliable as it allows quick selection of diverse analytes at little cost. The main target for nanobiosensor research includes the development of novel technologies in order to make improvements in the field of marker detection of human and animal disease, identification and study of therapeutic compounds, characterization of nano and bio materials and the development of biocatalysts. This paper has reviewed basic principles and various nano-structure based biosensors along with their applications in different areas such as biomedical and forensic, environmental, agricultural and the food sector and recent advancements.
{"title":"Nano-Biosensors from Agriculture to Nextgen Diagnostic Tools","authors":"Deepika Sharma, Ghanshyam Teli, Komal Gupta, G. Bansal, G. Gupta, P. Chawla","doi":"10.2174/2405461507666220131104843","DOIUrl":"https://doi.org/10.2174/2405461507666220131104843","url":null,"abstract":"\u0000\u0000Nanotechnology is thriving these days and plays a great role in the expansion of biosensors. A range of nanomaterials are used in the growth of biosensors in order to boost the performance and sensitivity of biosensors. Nanomaterials like nanowire, nanoparticles, carbon nanotubes, quantum dots etc. are helpful for increasing different properties like enzyme loading capacity, bioanalyte loading, good absorption as well as immobilization of enzymes. The skill of nanobiosensors becomes extra accurate and reliable as it allows quick selection of diverse analytes at little cost. The main target for nanobiosensor research includes the development of novel technologies in order to make improvements in the field of marker detection of human and animal disease, identification and study of therapeutic compounds, characterization of nano and bio materials and the development of biocatalysts. This paper has reviewed basic principles and various nano-structure based biosensors along with their applications in different areas such as biomedical and forensic, environmental, agricultural and the food sector and recent advancements.\u0000","PeriodicalId":10924,"journal":{"name":"Current Nanomaterials","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41580448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-31DOI: 10.2174/2405461507666220131110055
Francesca Persano, S. Persano, M. Guevara, G. Gigli, S. Leporatti
{"title":"The mRNA technology in cancer immunotherapy","authors":"Francesca Persano, S. Persano, M. Guevara, G. Gigli, S. Leporatti","doi":"10.2174/2405461507666220131110055","DOIUrl":"https://doi.org/10.2174/2405461507666220131110055","url":null,"abstract":"<jats:sec>\u0000<jats:title />\u0000<jats:p />\u0000</jats:sec>","PeriodicalId":10924,"journal":{"name":"Current Nanomaterials","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45569493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-17DOI: 10.2174/2405461507666220117114205
T. Y. Feyisa, Kirubel Teshome Tadele
The excessive application of carbamate and organophosphorus pesticides showed relatively high acute toxicity due to inhibition of acetylcholinesterase enzyme in the neural system of insects and mammals. This review aimed to assess the current outstanding performance of nanocomposite based enzyme-less electrochemical sensors toward determination of organophosphorus and carbamate pesticides detection. Enzyme based electrochemical sensor (biosensor) and classical (chromatographic) methods have been used widely for detection of organophosphorus and carbamate pesticides. However, instability related to enzymes and complex sample preparation, need for highly trained manpower and other numerous disadvantages associated with chromatographic techniques limit their application for pesticides detection in many conditions. Therefore, currently, nanocomposite based enzyme-less electrochemical sensors are good alternative to enzyme-based sensors for many researchers The reviewed literature revealed that, nanocomposite based enzyme-less sensors with numerous advantages have shown a comparable sensitivity with enzyme-integrated sensor for pesticide detection. Currently nanocomposite materials are widely used for many applications including the fabrication of promising sensors for pesticide detections. The promising sensing potential might be attributed to the special functional groups on the surface of the nanomaterials and their composite form, enabling them to substitute those expensive bio-recognition elements (enzymes) and used as non-bio-recognition element for detection of pesticides.
{"title":"Nanocomposite Based Enzyme-less Electrochemical Sensors for Carbamate and Organophosphorus Pesticides Detection","authors":"T. Y. Feyisa, Kirubel Teshome Tadele","doi":"10.2174/2405461507666220117114205","DOIUrl":"https://doi.org/10.2174/2405461507666220117114205","url":null,"abstract":"\u0000\u0000The excessive application of carbamate and organophosphorus pesticides showed relatively high acute toxicity due to inhibition of acetylcholinesterase enzyme in the neural system of insects and mammals.\u0000\u0000\u0000\u0000This review aimed to assess the current outstanding performance of nanocomposite based enzyme-less electrochemical sensors toward determination of organophosphorus and carbamate pesticides detection.\u0000\u0000\u0000\u0000Enzyme based electrochemical sensor (biosensor) and classical (chromatographic) methods have been used widely for detection of organophosphorus and carbamate pesticides. However, instability related to enzymes and complex sample preparation, need for highly trained manpower and other numerous disadvantages associated with chromatographic techniques limit their application for pesticides detection in many conditions. Therefore, currently, nanocomposite based enzyme-less electrochemical sensors are good alternative to enzyme-based sensors for many researchers\u0000\u0000\u0000\u0000The reviewed literature revealed that, nanocomposite based enzyme-less sensors with numerous advantages have shown a comparable sensitivity with enzyme-integrated sensor for pesticide detection.\u0000\u0000\u0000\u0000Currently nanocomposite materials are widely used for many applications including the fabrication of promising sensors for pesticide detections. The promising sensing potential might be attributed to the special functional groups on the surface of the nanomaterials and their composite form, enabling them to substitute those expensive bio-recognition elements (enzymes) and used as non-bio-recognition element for detection of pesticides.\u0000","PeriodicalId":10924,"journal":{"name":"Current Nanomaterials","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46453653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-06DOI: 10.2174/2405461507666220106114229
Punit Kumar, Sujata Malik, K. Dubey
The present world population is about 7.9 billion and it is increasing continuously. Thus, there is an urgent requirement to enhance the agricultural output sustainably. Agricultural approaches such as the use of advanced agriculture methods, high productivity varieties, and enhanced application of fertilizers and pesticides have significantly increased food grain production but in an unsustainable way. Chemical-based conventional fertilizers and pesticides have been found associated with environmental pollution and other unwanted effects on the ecosystem, soil quality, and soil microflora, etc. Nanomaterials may be used to replace conventional fertilizers and pesticides in agriculture. The aim of this review is to provide information about the harmful effects of chemical fertilizers and pesticides, and the use of nanomaterials in agriculture. Including this, the health risks of nanomaterials are discussed. This review article includes a survey of literature from different online sources (for example, Web of Science, PubMed, and Google Scholar, etc.). The improvement in agricultural output using chemical fertilizers and pesticides is considered unsustainable as it is increasing the cost of production, affecting the soil quality, disturbing nutrient availability in crops, and causing environmental pollution. Nanotechnology is a potent innovative practice and nanomaterials may be used in agriculture as nanofertilizers, nanopesticides, and nanosensors. Although these approaches have the potential to enhance agricultural productivity in a sustainable way, nanomaterials are also assumed to exhibit potential health risks to humans. Reports have indicated that nanomaterials have been found associated with many systematic diseases such as cardiovascular diseases, neurotoxicity, and toxicity to the reproductive system, etc. It is well accepted that chemical fertilizers and pesticides in agriculture cause environmental toxicity and affect ecosystem activity. Nanomaterials have the potential to enhance agricultural output, but these are also associated with health risks. Thus, detailed scientific studies must be conducted about the potential health risk of nanomaterials before their commercial applications in agriculture.
目前世界人口约为79亿，而且还在不断增加。因此，可持续提高农业产量是当务之急。采用先进的农业方法、高产品种以及加强化肥和农药的施用等农业方法显著提高了粮食产量，但其方式却是不可持续的。化学基础的常规肥料和农药已被发现与环境污染有关，并对生态系统、土壤质量和土壤微生物群等产生其他不良影响。纳米材料可以在农业中取代传统的肥料和农药。这篇综述的目的是提供有关化学肥料和农药的有害影响以及纳米材料在农业中的应用的信息。在此基础上，讨论了纳米材料的健康风险。这篇综述文章包括对来自不同在线资源的文献的调查(例如，Web of Science、PubMed和b谷歌Scholar等)。使用化肥和农药提高农业产量被认为是不可持续的，因为它增加了生产成本，影响了土壤质量，扰乱了作物的养分供应，并造成了环境污染。纳米技术是一种强有力的创新实践，纳米材料可以作为纳米肥料、纳米杀虫剂和纳米传感器用于农业。虽然这些方法有可能以可持续的方式提高农业生产力，但人们也认为纳米材料对人类的健康存在潜在风险。有报道表明，纳米材料与许多系统性疾病，如心血管疾病、神经毒性、生殖系统毒性等有关。农业中的化肥和农药引起环境毒性，影响生态系统活动，这是公认的。纳米材料具有提高农业产出的潜力，但这也与健康风险有关。因此，在纳米材料在农业上的商业应用之前，必须对其潜在的健康风险进行详细的科学研究。
{"title":"A review on the use of nanomaterials in agriculture: benefits and associated health risks","authors":"Punit Kumar, Sujata Malik, K. Dubey","doi":"10.2174/2405461507666220106114229","DOIUrl":"https://doi.org/10.2174/2405461507666220106114229","url":null,"abstract":"\u0000\u0000The present world population is about 7.9 billion and it is increasing continuously. Thus, there is an urgent requirement to enhance the agricultural output sustainably. Agricultural approaches such as the use of advanced agriculture methods, high productivity varieties, and enhanced application of fertilizers and pesticides have significantly increased food grain production but in an unsustainable way. Chemical-based conventional fertilizers and pesticides have been found associated with environmental pollution and other unwanted effects on the ecosystem, soil quality, and soil microflora, etc. Nanomaterials may be used to replace conventional fertilizers and pesticides in agriculture.\u0000\u0000\u0000\u0000The aim of this review is to provide information about the harmful effects of chemical fertilizers and pesticides, and the use of nanomaterials in agriculture. Including this, the health risks of nanomaterials are discussed.\u0000\u0000\u0000\u0000This review article includes a survey of literature from different online sources (for example, Web of Science, PubMed, and Google Scholar, etc.).\u0000\u0000\u0000\u0000The improvement in agricultural output using chemical fertilizers and pesticides is considered unsustainable as it is increasing the cost of production, affecting the soil quality, disturbing nutrient availability in crops, and causing environmental pollution. Nanotechnology is a potent innovative practice and nanomaterials may be used in agriculture as nanofertilizers, nanopesticides, and nanosensors. Although these approaches have the potential to enhance agricultural productivity in a sustainable way, nanomaterials are also assumed to exhibit potential health risks to humans. Reports have indicated that nanomaterials have been found associated with many systematic diseases such as cardiovascular diseases, neurotoxicity, and toxicity to the reproductive system, etc.\u0000\u0000\u0000\u0000It is well accepted that chemical fertilizers and pesticides in agriculture cause environmental toxicity and affect ecosystem activity. Nanomaterials have the potential to enhance agricultural output, but these are also associated with health risks. Thus, detailed scientific studies must be conducted about the potential health risk of nanomaterials before their commercial applications in agriculture.\u0000","PeriodicalId":10924,"journal":{"name":"Current Nanomaterials","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48964950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-30DOI: 10.2174/2405461506666211130152334
R. Murugesan, S. Raman, A. Radhakrishnan
Recently, Nanomaterials based nano-composite materials play the role of various field. Especially, Carbon nanotube based materials are involved in the bio-medical applications.Since, their exclusive and exciting property, researchers worldwide have extensively involved in trans-modulating the carbon nanotubes into a viable medico-friendly system. These active researches paved the path towards targeted drug delivery, diagnostic techniques, and bio-analytical applications. Despite these exciting properties, which accomplish the probable for biomedical applications, they hold Biosafety issues. This broad-spectrum review has discussed different aspects of carbon nanotubes and carbon nanotube-based systems related to biomedical applications. Adding to this, a short chronological description of these tiny yet powerful particles given, followed by a discussion regarding their types, properties, methods of synthesis, scale-up, purification techniques and characterization aspects of carbon nanotubes. In the later part, the functionalization of carbon nanotubes was reviewed in detail, which is important to make them biocompatible and stable in biological systems and render them a great property of loading various biomolecules diagnostic and therapeutic moieties. Lastly, an inclusive description of the potential biomedical applications has been given followed by insights into the future.
{"title":"Future trends in carbon nanotubes: Process towards a viable biomedical solution","authors":"R. Murugesan, S. Raman, A. Radhakrishnan","doi":"10.2174/2405461506666211130152334","DOIUrl":"https://doi.org/10.2174/2405461506666211130152334","url":null,"abstract":"\u0000\u0000Recently, Nanomaterials based nano-composite materials play the role of various field. Especially, Carbon nanotube based materials are involved in the bio-medical applications.Since, their exclusive and exciting property, researchers worldwide have extensively involved in trans-modulating the carbon nanotubes into a viable medico-friendly system. \u0000\u0000\u0000\u0000\u0000These active researches paved the path towards targeted drug delivery, diagnostic techniques, and bio-analytical applications. Despite these exciting properties, which accomplish the probable for biomedical applications, they hold Biosafety issues. \u0000\u0000\u0000\u0000\u0000 This broad-spectrum review has discussed different aspects of carbon nanotubes and carbon nanotube-based systems related to biomedical applications. \u0000\u0000\u0000\u0000\u0000Adding to this, a short chronological description of these tiny yet powerful particles given, followed by a discussion regarding their types, properties, methods of synthesis, scale-up, purification techniques and characterization aspects of carbon nanotubes. \u0000\u0000\u0000\u0000\u0000 In the later part, the functionalization of carbon nanotubes was reviewed in detail, which is important to make them biocompatible and stable in biological systems and render them a great property of loading various biomolecules diagnostic and therapeutic moieties. Lastly, an inclusive description of the potential biomedical applications has been given followed by insights into the future.\u0000\u0000","PeriodicalId":10924,"journal":{"name":"Current Nanomaterials","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44357422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-09-08DOI: 10.2174/2405461506666210908142533
Anjum Mobeen Syeda, H. Khadri, K. Riazunnisa
Biological synthesis via greener route attained eclectic interest for research investigators due to their reliable, sustainable, ecofriendly, and non-toxic nature since numerous efforts are made laterally with reflective applications by synthesizing diverse nanomaterials embraces, metals/metal oxide, hybrid, and bioinspired materials during past era. The present review reports and aimed to update and uncover all the minutiae regarding two medicinal plants sources allied with diversified metal and non-metal nanoparticle synthesis thru greener approach. The ornamental, medicinal plants such as Catharanthus roseus and Moringa oleifera have been broadly sightseen for the synthesis of varied nanoparticles due to existence of their innumerable phytochemical configuration which may act as bio-reducing and stabilizing agent by metallic/metal oxides, and non-metallic precursors such as silver, gold, sulphur, copper oxide, iron oxide, ruthenium oxide nanoparticles using either leaves infusions or part/whole plant. This report highlights with a phenomenon of using different parts of these two plants and their applications in varied scientific domains which may act as a promising drug candidates for drug delivery mechanism by means of nano approach.
{"title":"Green synthesis of metal and metal-oxide nanoparticles pertinent to Catharanthus roseus and Moringa oleifera-A Review","authors":"Anjum Mobeen Syeda, H. Khadri, K. Riazunnisa","doi":"10.2174/2405461506666210908142533","DOIUrl":"https://doi.org/10.2174/2405461506666210908142533","url":null,"abstract":"\u0000\u0000 Biological synthesis via greener route attained eclectic interest for research investigators due to their reliable, sustainable, ecofriendly, and non-toxic nature since numerous efforts are made laterally with reflective applications by synthesizing diverse nanomaterials embraces, metals/metal oxide, hybrid, and bioinspired materials during past era.\u0000\u0000\u0000\u0000\u0000The present review reports and aimed to update and uncover all the minutiae regarding two medicinal plants sources allied with diversified metal and non-metal nanoparticle synthesis thru greener approach. \u0000\u0000\u0000\u0000\u0000 The ornamental, medicinal plants such as Catharanthus roseus and Moringa oleifera have been broadly sightseen for the synthesis of varied nanoparticles due to existence of their innumerable phytochemical configuration which may act as bio-reducing and stabilizing agent by metallic/metal oxides, and non-metallic precursors such as silver, gold, sulphur, copper oxide, iron oxide, ruthenium oxide nanoparticles using either leaves infusions or part/whole plant. \u0000\u0000\u0000\u0000\u0000 This report highlights with a phenomenon of using different parts of these two plants and their applications in varied scientific domains which may act as a promising drug candidates for drug delivery mechanism by means of nano approach.\u0000\u0000","PeriodicalId":10924,"journal":{"name":"Current Nanomaterials","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49361548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-31DOI: 10.2174/2405461506666210831145230
A. Badran, J. Mesmar, Nadine Wehbe, R. Kurdi, D. Patra, E. Baydoun
Breast cancer remains one of the most common cancers in women worldwide, and despite significant improvements in treatment modalities, the prognosis of this cancer is still poor. Herbs and plant extracts have been associated with various health benefits, and traditional folk medicine is still receiving great interest among patients as proven by accumulated records, tolerable side effects of herbal compounds compared to their synthetic counterparts, and low cost. Curcumin is a polyphenol identified as the main active ingredient in turmeric and has been used in the treatment of various diseases and ailments. Additionally, the pharmacological activities of curcumin on many cancers have been investigated substantially due to its ability to regulate many signaling pathways involved in cancer tumorigenesis and metastasis. However, the low solubility and bioavailability of curcumin limit its benefits, urging the need for new curcumin formulations and delivery systems. Nanotechnology has been widely publicized in cancer treatment not only to overcome the limitations of poorly soluble and physiologically unstable compounds but also to improve the delivery of the drug to the diseased site and cellular uptake. In this review, we summarized the main anti-tumor effect of curcumin and its mode of action on breast cancer and focused on the anticancer efficacy of various and recent curcumin nanoformulations and delivery systems. Such nanotechnological systems could pave the way to address a new future direction in this research area, enhancing the therapeutic potential of curcumin in the treatment of breast cancer. In the next few years, there will be more focus on developing curcumin-based materials for breast cancer treatment.
{"title":"Curcumin-based nanoformulations to target breast cancer: current trends and challenges","authors":"A. Badran, J. Mesmar, Nadine Wehbe, R. Kurdi, D. Patra, E. Baydoun","doi":"10.2174/2405461506666210831145230","DOIUrl":"https://doi.org/10.2174/2405461506666210831145230","url":null,"abstract":"\u0000\u0000Breast cancer remains one of the most common cancers in women worldwide, and despite significant improvements in treatment modalities, the prognosis of this cancer is still poor. Herbs and plant extracts have been associated with various health benefits, and traditional folk medicine is still receiving great interest among patients as proven by accumulated records, tolerable side effects of herbal compounds compared to their synthetic counterparts, and low cost. Curcumin is a polyphenol identified as the main active ingredient in turmeric and has been used in the treatment of various diseases and ailments. Additionally, the pharmacological activities of curcumin on many cancers have been investigated substantially due to its ability to regulate many signaling pathways involved in cancer tumorigenesis and metastasis. However, the low solubility and bioavailability of curcumin limit its benefits, urging the need for new curcumin formulations and delivery systems. Nanotechnology has been widely publicized in cancer treatment not only to overcome the limitations of poorly soluble and physiologically unstable compounds but also to improve the delivery of the drug to the diseased site and cellular uptake. In this review, we summarized the main anti-tumor effect of curcumin and its mode of action on breast cancer and focused on the anticancer efficacy of various and recent curcumin nanoformulations and delivery systems. Such nanotechnological systems could pave the way to address a new future direction in this research area, enhancing the therapeutic potential of curcumin in the treatment of breast cancer. In the next few years, there will be more focus on developing curcumin-based materials for breast cancer treatment.\u0000","PeriodicalId":10924,"journal":{"name":"Current Nanomaterials","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41725992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：