Pub Date : 2023-10-09DOI: 10.37290/ctnr2641-452x.21:380-385
Deyin Song, Chunhua Yuan, Suyu Shi
We have evaluated the clinical benefits of Shenshu Dingchuan decoction in chronic bronchial asthma patients treated with budesonide or formoterol. To this end, chronic bronchial asthma patients were divided into two groups and treated with budesonide or formoterol alone (the control group) or budesonide or formoterol plus Shenshu Dingchuan decoction (the treatment group). Shenshu Dingchuan decoction combined with budesonide formoterol decreased traditional Chinese medicine syndrome scores, elevated forced expiratory volume in one second, forced vital capacity, and forced expiratory volume in one second/forced vital capacity levels, decreased fractional exhaust nitric oxide and total immunoglobulin E levels, and the elevated total effective rate after treatment. In conclusion, these observed changes reflect a marked clinical improvement in lung function.
{"title":"Shenshu Dingchuan Decoction Enhances Clinical Benefits of Budesonide/Formoterol in Chronic Bronchial Asthma Patients","authors":"Deyin Song, Chunhua Yuan, Suyu Shi","doi":"10.37290/ctnr2641-452x.21:380-385","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.21:380-385","url":null,"abstract":"We have evaluated the clinical benefits of Shenshu Dingchuan decoction in chronic bronchial asthma patients treated with budesonide or formoterol. To this end, chronic bronchial asthma patients were divided into two groups and treated with budesonide or formoterol alone (the control group) or budesonide or formoterol plus Shenshu Dingchuan decoction (the treatment group). Shenshu Dingchuan decoction combined with budesonide formoterol decreased traditional Chinese medicine syndrome scores, elevated forced expiratory volume in one second, forced vital capacity, and forced expiratory volume in one second/forced vital capacity levels, decreased fractional exhaust nitric oxide and total immunoglobulin E levels, and the elevated total effective rate after treatment. In conclusion, these observed changes reflect a marked clinical improvement in lung function.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135043469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-09DOI: 10.37290/ctnr2641-452x.21:356-360
Chunyang Yin, Weiwei Gao, Xiaoli Tang
This study was designed to explore whether Chinese herbals could enhance the clinical efficacy of levofloxacin and a combination of antituberculosis drugs. To this end, a group of pulmonary patients were treated with pyrazinamide, isoniazid, ethambutol, and levofloxacin (control), and the other group (treatment) also received a combination of extra Chinese herbal compounds. After 6 months of therapy, the total efficiency of lesion absorption in the treatment group was higher than in the control group. The treatment group had a higher peak expiratory flow rate, a higher percentage of forced vital capacity, a higher percentage of the first second of forced expiration, higher levels of immunoglobulin A, immunoglobulin G, immunoglobulin M, and CD4+, and lower levels of CD8+ compared to the control group. The levels of proinflammatory cytokines were lower, the sputum conversion rate was higher, and the recurrence rate was lower in the treatment group than the control group. After therapy, the treatment group had higher scores in the quality of daily life, spirit, appetite, fatigue, and sleep assessments. In conclusion, therapy with levofloxacin and antituberculosis drugs combined with Chinese herbal compounds for patients with pulmonary tuberculosis could effectively relieve the inflammatory reaction, promote lesion absorption, and thus improve their lung function and promote recovery.
{"title":"Augmentation of the Clinical Efficacy of Levofloxacin and Antituberculosis Drugs by Chinese Herbal Preparations in Pulmonary Tuberculosis","authors":"Chunyang Yin, Weiwei Gao, Xiaoli Tang","doi":"10.37290/ctnr2641-452x.21:356-360","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.21:356-360","url":null,"abstract":"This study was designed to explore whether Chinese herbals could enhance the clinical efficacy of levofloxacin and a combination of antituberculosis drugs. To this end, a group of pulmonary patients were treated with pyrazinamide, isoniazid, ethambutol, and levofloxacin (control), and the other group (treatment) also received a combination of extra Chinese herbal compounds. After 6 months of therapy, the total efficiency of lesion absorption in the treatment group was higher than in the control group. The treatment group had a higher peak expiratory flow rate, a higher percentage of forced vital capacity, a higher percentage of the first second of forced expiration, higher levels of immunoglobulin A, immunoglobulin G, immunoglobulin M, and CD4+, and lower levels of CD8+ compared to the control group. The levels of proinflammatory cytokines were lower, the sputum conversion rate was higher, and the recurrence rate was lower in the treatment group than the control group. After therapy, the treatment group had higher scores in the quality of daily life, spirit, appetite, fatigue, and sleep assessments. In conclusion, therapy with levofloxacin and antituberculosis drugs combined with Chinese herbal compounds for patients with pulmonary tuberculosis could effectively relieve the inflammatory reaction, promote lesion absorption, and thus improve their lung function and promote recovery.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135043613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-27DOI: 10.37290/ctnr2641-452x.21:478-484
Lei He
The effect of behavioral training and nursing intervention on the postoperative recovery and nutritional status of elderly patients with benign prostatic hyperplasia was examined. The frequency and duration of bladder spasm episodes and the incidence of adverse effects were lower in the patients receiving research than in the control group (P < 0.05). The self-rating anxiety scale and the self-rating depression scale decreased in both groups after the nursing intervention and were lower in the research group than in the control group (P < 0.05), while the General Quality of Life Assessment Questionnaire scores increased in both groups and were higher in the research group (P < 0.05). Furthermore, the level of satisfaction was significantly higher in the research group than the control group (P < 0.05). Finally, the number of people with good nutritional status was higher in the research group, and the neutrophil-to-lymphocyte ratio was lower than in the control group (P < 0.05). Thus, we recommend behavioral training in nursing for benign prostatic hyperplasia patients in the future to improve their postoperative rehabilitation and nutritional status.
{"title":"Behavioral Training with Nursing Intervention Improves Postoperative Rehabilitation and Nutritional Status of Elderly Patients with Benign Prostatic Hyperplasia","authors":"Lei He","doi":"10.37290/ctnr2641-452x.21:478-484","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.21:478-484","url":null,"abstract":"The effect of behavioral training and nursing intervention on the postoperative recovery and nutritional status of elderly patients with benign prostatic hyperplasia was examined. The frequency and duration of bladder spasm episodes and the incidence of adverse effects were lower in the patients receiving research than in the control group (P < 0.05). The self-rating anxiety scale and the self-rating depression scale decreased in both groups after the nursing intervention and were lower in the research group than in the control group (P < 0.05), while the General Quality of Life Assessment Questionnaire scores increased in both groups and were higher in the research group (P < 0.05). Furthermore, the level of satisfaction was significantly higher in the research group than the control group (P < 0.05). Finally, the number of people with good nutritional status was higher in the research group, and the neutrophil-to-lymphocyte ratio was lower than in the control group (P < 0.05). Thus, we recommend behavioral training in nursing for benign prostatic hyperplasia patients in the future to improve their postoperative rehabilitation and nutritional status.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":"205 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134904041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-10DOI: 10.37290/ctnr2641-452x.21:321-325
Qian Guo, Honggang Ni, Xinjie Wang, Long Ling
The effect of Tongmai Tangyanming Capsules on diabetic retinopathy in zebrafish was investigated. Zebrafish were intraperitoneally injected with streptozotocin to stimulate diabetic retinopathy. Treatment of diabetic zebrafish with Tongmai Tangyanming Capsules diminished the progression of diabetic retinopathy by regulating the expression of pro-inflammatory biomarkers and nitric oxide. The results of this study offer an experimental basis for the use of this drug in diabetic retinopathy treatment and increase the selection of preventive drugs for diabetic retinopathy development.
{"title":"Effect of Tongmai Tangyanming Capsules on Diabetic Retinopathy in Zebrafish","authors":"Qian Guo, Honggang Ni, Xinjie Wang, Long Ling","doi":"10.37290/ctnr2641-452x.21:321-325","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.21:321-325","url":null,"abstract":"The effect of Tongmai Tangyanming Capsules on diabetic retinopathy in zebrafish was investigated. Zebrafish were intraperitoneally injected with streptozotocin to stimulate diabetic retinopathy. Treatment of diabetic zebrafish with Tongmai Tangyanming Capsules diminished the progression of diabetic retinopathy by regulating the expression of pro-inflammatory biomarkers and nitric oxide. The results of this study offer an experimental basis for the use of this drug in diabetic retinopathy treatment and increase the selection of preventive drugs for diabetic retinopathy development.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48156150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-05DOI: 10.37290/ctnr2641-452x.21:461-467
Jian Liu, Changzhu Sun, Xiaoling Chu
We are in the process of recovering patients undergoing treatments with Sophora flavescens (experimental) or potassium permanganate (control) fumigation following anal fistula surgery. The experimental group had a shorter wound healing time and lower pain measurement on the Visual Analogue Scale on postoperative days 7 and 14 than the control group (P < 0.05). Although no inter-group notable difference was identified in clinical efficacy (P > 0.05), the anal function of the experimental group was improved, and the levels of pro-inflammatory cytokines were lower after treatment (P < 0.05). Assessment of the nutritional status after surgery, key to postoperative recovery, showed that the weight and upper arm circumference decreased in both groups after treatment, but the experimental group was higher than the control group (P < 0.05), and prealbumin, albumin, and transferrin were also higher in the experimental group than in the control group after treatment (P < 0.05). Finally, the two groups did not differ significantly in adverse reactions and relapse (P > 0.05). SF facilitates wound healing after anal fistula surgery, mitigates patient pain, and improves anal health.
{"title":"The Efficacy of Sophora Flavescens Fumigation in Improving Anal Health After Anal Fistula Surgery","authors":"Jian Liu, Changzhu Sun, Xiaoling Chu","doi":"10.37290/ctnr2641-452x.21:461-467","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.21:461-467","url":null,"abstract":"We are in the process of recovering patients undergoing treatments with Sophora flavescens (experimental) or potassium permanganate (control) fumigation following anal fistula surgery. The experimental group had a shorter wound healing time and lower pain measurement on the Visual Analogue Scale on postoperative days 7 and 14 than the control group (P < 0.05). Although no inter-group notable difference was identified in clinical efficacy (P > 0.05), the anal function of the experimental group was improved, and the levels of pro-inflammatory cytokines were lower after treatment (P < 0.05). Assessment of the nutritional status after surgery, key to postoperative recovery, showed that the weight and upper arm circumference decreased in both groups after treatment, but the experimental group was higher than the control group (P < 0.05), and prealbumin, albumin, and transferrin were also higher in the experimental group than in the control group after treatment (P < 0.05). Finally, the two groups did not differ significantly in adverse reactions and relapse (P > 0.05). SF facilitates wound healing after anal fistula surgery, mitigates patient pain, and improves anal health.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":"307 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135369601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-30DOI: 10.37290/ctnr2641-452x.21:485-489
Lin Lei, Baohua Hao, Zhiyu Jia, Pengfei Qu
In this study, we have explored the reasons for the poor efficiency of 3′-deoxyadenosine in the treatment of rheumatoid arthritis. The effects of cordycepin and methotrexate on osteoclastogenesis were evaluated using the culture system of rat whole bone marrow cells and immunofluorescence staining with Kat1, a novel cell-surface antigen specifically expressed on rat osteoclasts. The effect of cordycepin on osteoclast formation was evaluated by tartaric acid-resistant phosphatase staining of bone marrow cell culture lines (pre-osteoclast formation lines) in which mesenchymal cells were removed. In the bone marrow culture system for evaluating osteoclastogenesis, methotrexate-induced suppression of osteoclastogenesis was abrogated only by the addition of cordycepin. In the pre-osteoclast formation system, cordycepin (3′-deoxyadenosine) was found to have no significant effect on osteoclast formation. To sum up, cordycepin should be carefully used in some cases of rheumatoid arthritis treated with methotrexate and in the severe stages of rheumatoid arthritis.
{"title":"Cordycepin Abrogates Methotrexate-Induced Suppression of Osteoclastogenesis","authors":"Lin Lei, Baohua Hao, Zhiyu Jia, Pengfei Qu","doi":"10.37290/ctnr2641-452x.21:485-489","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.21:485-489","url":null,"abstract":"In this study, we have explored the reasons for the poor efficiency of 3′-deoxyadenosine in the treatment of rheumatoid arthritis. The effects of cordycepin and methotrexate on osteoclastogenesis were evaluated using the culture system of rat whole bone marrow cells and immunofluorescence staining with Kat1, a novel cell-surface antigen specifically expressed on rat osteoclasts. The effect of cordycepin on osteoclast formation was evaluated by tartaric acid-resistant phosphatase staining of bone marrow cell culture lines (pre-osteoclast formation lines) in which mesenchymal cells were removed. In the bone marrow culture system for evaluating osteoclastogenesis, methotrexate-induced suppression of osteoclastogenesis was abrogated only by the addition of cordycepin. In the pre-osteoclast formation system, cordycepin (3′-deoxyadenosine) was found to have no significant effect on osteoclast formation. To sum up, cordycepin should be carefully used in some cases of rheumatoid arthritis treated with methotrexate and in the severe stages of rheumatoid arthritis.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":"388 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136241907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-29DOI: 10.37290/ctnr2641-452x.22:1-7
Yifan Liu, Jintang Jia
Iodine nutrition plays a central role in the normal physiological function of the thyroid gland, and it is a major factor in thyroid hormone synthesis. A meta-analysis was used to measure the efficacy of oral iodine-131 combined with nutritional management in thyroid cancer patients after surgery. Computer searches were conducted on various databases, with the search time limited to January 2011 to December 2021, and the literature retrieved was limited to randomized controlled trials. Data extraction and quality evaluation were performed for the included literature, and meta-analysis was conducted by RevMan 5.3 software. A total of 9 literatures were obtained, all in English, with a sample size of 10,219 cases, containing 6,845 cases in the study group (oral iodine-131 + nutritional management) together with 3,374 cases in the control group (oral iodine-131 alone). The study group received oral administration of iodine-131 and nutritional management (low-iodine diet). The outcomes of the meta-analysis revealed that the clinical symptoms of thyroid cancer patients were improved after oral administration of iodine-131 after surgery. No statistical differences could be observed in the incidence of adverse reactions, recurrence rate, or metastasis rate of outcome indicators. To sum up, oral administration of iodine-131 combined with nutritional management has certain clinical effects in patients with thyroid cancer after surgery, but due to the limited literature included and low data quality, the conclusions of this study still need to be further verified.
{"title":"Postoperative Oral Iodine-131 Combined with Nutritional Management for the Management of Thyroid Cancer: A Meta-Analysis","authors":"Yifan Liu, Jintang Jia","doi":"10.37290/ctnr2641-452x.22:1-7","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.22:1-7","url":null,"abstract":"Iodine nutrition plays a central role in the normal physiological function of the thyroid gland, and it is a major factor in thyroid hormone synthesis. A meta-analysis was used to measure the efficacy of oral iodine-131 combined with nutritional management in thyroid cancer patients after surgery. Computer searches were conducted on various databases, with the search time limited to January 2011 to December 2021, and the literature retrieved was limited to randomized controlled trials. Data extraction and quality evaluation were performed for the included literature, and meta-analysis was conducted by RevMan 5.3 software. A total of 9 literatures were obtained, all in English, with a sample size of 10,219 cases, containing 6,845 cases in the study group (oral iodine-131 + nutritional management) together with 3,374 cases in the control group (oral iodine-131 alone). The study group received oral administration of iodine-131 and nutritional management (low-iodine diet). The outcomes of the meta-analysis revealed that the clinical symptoms of thyroid cancer patients were improved after oral administration of iodine-131 after surgery. No statistical differences could be observed in the incidence of adverse reactions, recurrence rate, or metastasis rate of outcome indicators. To sum up, oral administration of iodine-131 combined with nutritional management has certain clinical effects in patients with thyroid cancer after surgery, but due to the limited literature included and low data quality, the conclusions of this study still need to be further verified.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":"37 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139348552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
We have examined the effect of Yishen Juanbi decoction combined with predictive nursing intervention on the prognosis, pain, and nutritional status of patients with ankylosing spondylitis. Ankylosing spondylitis patients received oral Yishen Juanbi decoction, followed by routine nursing intervention or predictive nursing intervention. The visual analog scale score and bath ankylosing spondylitis functional index score in the predictive nursing intervention were lower relative to the routine nursing intervention (P < 0.05). The predictive nursing intervention also had better quality of life than the routine nursing intervention group (P < 0.05). Serum total protein and albumin levels were higher in the predictive nursing intervention group than the routine nursing intervention group (P < 0.05), while serum IgA, IgM, and IgG levels were lower (P < 0.05). The nursing satisfaction of patients in the predictive nursing intervention group was higher compared to the routine nursing intervention group (P < 0.05). In conclusion, Yishen Juanbi decoction combined with predictive nursing can reduce pain, improve the nutritional status, and promote the motor function and quality of life of ankylosing spondylitis patients.
{"title":"Yishen Juanbi Decoction Combined with Predictive Nursing Intervention Improves the Prognosis, Pain, and Nutritional Status of Patients with Ankylosing Spondylitis","authors":"Wenting Zhou, Zhenhua Zhao, Yu Zhang, Zhensuo Zhao, Zhiguang Zhai","doi":"10.37290/ctnr2641-452x.21:509-515","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.21:509-515","url":null,"abstract":"We have examined the effect of Yishen Juanbi decoction combined with predictive nursing intervention on the prognosis, pain, and nutritional status of patients with ankylosing spondylitis. Ankylosing spondylitis patients received oral Yishen Juanbi decoction, followed by routine nursing intervention or predictive nursing intervention. The visual analog scale score and bath ankylosing spondylitis functional index score in the predictive nursing intervention were lower relative to the routine nursing intervention (P < 0.05). The predictive nursing intervention also had better quality of life than the routine nursing intervention group (P < 0.05). Serum total protein and albumin levels were higher in the predictive nursing intervention group than the routine nursing intervention group (P < 0.05), while serum IgA, IgM, and IgG levels were lower (P < 0.05). The nursing satisfaction of patients in the predictive nursing intervention group was higher compared to the routine nursing intervention group (P < 0.05). In conclusion, Yishen Juanbi decoction combined with predictive nursing can reduce pain, improve the nutritional status, and promote the motor function and quality of life of ankylosing spondylitis patients.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":"12 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139349605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-18DOI: 10.37290/ctnr2641-452x.21:516-523
Xiaorong Wang, Wenjing Hu, Tuya Wang, Gaowa Wuyun
The Mongolian medicine (Awei Wu Wei pills) was evaluated as a potential treatment for Hirschsprung’s migraine in a Sprague-Dawley rat model. The results of this study showed a dose-dependent decrease in the duration of ear redness and head scratching, two behavioral attributes of migraine. The mechanism involves inhibition of the c-Jun N-terminal kinase signaling pathway, leading to decreased calcitonin gene-related peptide and nitric oxide expression and reducing vasodilation, serotonin, dopamine, and beta-endorphin concentrations following administration of Awei Wu Wei pills. In conclusion, Awei Wu Wei pills demonstrate promising antimigraine effects.
在 Sprague-Dawley 大鼠模型中评估了蒙药（阿魏五味丸）治疗赫氏偏头痛的潜力。研究结果表明，该蒙药对偏头痛的两种行为特征--耳朵发红和搔头的持续时间有剂量依赖性的减少作用。其机制涉及抑制 c-Jun N 端激酶信号通路，导致降钙素基因相关肽和一氧化氮表达减少，以及服用阿魏五味丸后血管舒张、血清素、多巴胺和β-内啡肽浓度降低。总之，阿魏五味丸具有良好的抗偏头痛作用。
{"title":"Antimigraine Effects of Awei Wu Wei Pills, A Monk’s Medicine","authors":"Xiaorong Wang, Wenjing Hu, Tuya Wang, Gaowa Wuyun","doi":"10.37290/ctnr2641-452x.21:516-523","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.21:516-523","url":null,"abstract":"The Mongolian medicine (Awei Wu Wei pills) was evaluated as a potential treatment for Hirschsprung’s migraine in a Sprague-Dawley rat model. The results of this study showed a dose-dependent decrease in the duration of ear redness and head scratching, two behavioral attributes of migraine. The mechanism involves inhibition of the c-Jun N-terminal kinase signaling pathway, leading to decreased calcitonin gene-related peptide and nitric oxide expression and reducing vasodilation, serotonin, dopamine, and beta-endorphin concentrations following administration of Awei Wu Wei pills. In conclusion, Awei Wu Wei pills demonstrate promising antimigraine effects.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":"46 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139350021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-12DOI: 10.37290/ctnr2641-452x.21:468-472
Bing Wu, Yue Zhang
Uremia not only involves the accumulation of small molecules of uremic solutes in plasma but also ecological dysregulation of the gut microbiota. At present, hemodialysis is the preferred method for clinical management of uremic patients to avoid complications such as intestinal diseases caused by intestinal flora disturbances. Herein, we have attempted to clarify the clinical value of probiotics in progressive nutritional support nursing for uremic hemodialysis patients. One hundred and thirty-six uremic patients undergoing hemodialysis in our hospital between October 2021 and October 2022 were divided into experimental and control groups. The control group underwent conventional nursing care, whereas the experimental group underwent progressive nutritional support nursing (intervention group). After intervention, the visual analogue scale scores of the EuroQoL-5 Dimension Questionnaire in the experimental group were elevated relative to those in the controls (P < 0.05). The health-related quality of life questions that included creatinine clearance rate, urea nitrogen clearance rate, body mass index, and albumin were higher in the experimental group than controls, whereas the white blood cell count in the experimental group was lower than controls (P < 0.05). Furthermore, the total complication rate in the experimental group was lower than the control group (P < 0.05). In summary, applying progressive nutritional support nursing to uremic patients can improve clinical indicators and reduce the incidence of complications.
{"title":"Clinical Value of Progressive Nutritional Support Nursing in Uremic Patients Undergoing Hemodialysis","authors":"Bing Wu, Yue Zhang","doi":"10.37290/ctnr2641-452x.21:468-472","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.21:468-472","url":null,"abstract":"Uremia not only involves the accumulation of small molecules of uremic solutes in plasma but also ecological dysregulation of the gut microbiota. At present, hemodialysis is the preferred method for clinical management of uremic patients to avoid complications such as intestinal diseases caused by intestinal flora disturbances. Herein, we have attempted to clarify the clinical value of probiotics in progressive nutritional support nursing for uremic hemodialysis patients. One hundred and thirty-six uremic patients undergoing hemodialysis in our hospital between October 2021 and October 2022 were divided into experimental and control groups. The control group underwent conventional nursing care, whereas the experimental group underwent progressive nutritional support nursing (intervention group). After intervention, the visual analogue scale scores of the EuroQoL-5 Dimension Questionnaire in the experimental group were elevated relative to those in the controls (P < 0.05). The health-related quality of life questions that included creatinine clearance rate, urea nitrogen clearance rate, body mass index, and albumin were higher in the experimental group than controls, whereas the white blood cell count in the experimental group was lower than controls (P < 0.05). Furthermore, the total complication rate in the experimental group was lower than the control group (P < 0.05). In summary, applying progressive nutritional support nursing to uremic patients can improve clinical indicators and reduce the incidence of complications.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135354366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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