Pub Date : 2023-05-02DOI: 10.37290/ctnr2641-452x.21:194-197
Chien-Ming Lin, Huan-Nung Chao, Han-Fang Tseng, Chih-Hung Lin, Chan-Yen Kuo
Chronic kidney disease is characterized by persistent abnormalities in urinary function, structural abnormalities, or impaired excretory functions that indicate the loss of functional nephrons. Cardiovascular disease and death are the most common complications of chronic kidney disease. Once chronic kidney disease is established, treatment has proven ineffective. Therefore, research efforts should be devoted to uncovering early disease mechanisms and alternative treatment options. Traditionally, garlic has been used as a pharmacological agent, especially when aged, in addition to its application as a food flavoring agent. Studies have suggested that garlic has anti-inflammatory and immunomodulatory properties. The effects of garlic on renal function have been summarized in cell culture, animal, and clinical studies.
{"title":"Role of Garlic (Allium Sativum L.) in Chronic Kidney Diseases: A Short Review","authors":"Chien-Ming Lin, Huan-Nung Chao, Han-Fang Tseng, Chih-Hung Lin, Chan-Yen Kuo","doi":"10.37290/ctnr2641-452x.21:194-197","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.21:194-197","url":null,"abstract":"Chronic kidney disease is characterized by persistent abnormalities in urinary function, structural abnormalities, or impaired excretory functions that indicate the loss of functional nephrons. Cardiovascular disease and death are the most common complications of chronic kidney disease. Once chronic kidney disease is established, treatment has proven ineffective. Therefore, research efforts should be devoted to uncovering early disease mechanisms and alternative treatment options. Traditionally, garlic has been used as a pharmacological agent, especially when aged, in addition to its application as a food flavoring agent. Studies have suggested that garlic has anti-inflammatory and immunomodulatory properties. The effects of garlic on renal function have been summarized in cell culture, animal, and clinical studies.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":"234 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135270253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-18DOI: 10.37290/ctnr2641-452x.21:187-193
Lee Tang, John Jenn Yenn Lu, Sheau-Chung Tang
Cachexia is a multifactorial and multi-organ condition that increases the mortality rate of patients with advanced cancer. Amelioration of cancer patients’ weight loss and inflammatory status are critical to the treatment’s success. Cachexia contains a significant drop in body weight and a rapid loss of lipoprotein, accompanied by an inflammatory state. In the late stage of cancer, anorexia and cachexia may occur at the same time, a condition called anorexia and cachexia syndrome. Keeping abreast of the patient’s inflammatory and nutritional status is of utmost importance for optimal treatment. This review explores the contribution of nutrient changes and the novel biomarker proteins in anorexia and cachexia syndrome. Functional assessment using anorexia and cachexia therapy assessment tools can monitor and provide early signals for anorexia and cachexia syndrome and suggest mechanism-based interventions to improve the status of cachexia with appropriate nutrients or drugs.
{"title":"Functional Assessment of Therapy Tools for Cancer Cachexia: A Review","authors":"Lee Tang, John Jenn Yenn Lu, Sheau-Chung Tang","doi":"10.37290/ctnr2641-452x.21:187-193","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.21:187-193","url":null,"abstract":"Cachexia is a multifactorial and multi-organ condition that increases the mortality rate of patients with advanced cancer. Amelioration of cancer patients’ weight loss and inflammatory status are critical to the treatment’s success. Cachexia contains a significant drop in body weight and a rapid loss of lipoprotein, accompanied by an inflammatory state. In the late stage of cancer, anorexia and cachexia may occur at the same time, a condition called anorexia and cachexia syndrome. Keeping abreast of the patient’s inflammatory and nutritional status is of utmost importance for optimal treatment. This review explores the contribution of nutrient changes and the novel biomarker proteins in anorexia and cachexia syndrome. Functional assessment using anorexia and cachexia therapy assessment tools can monitor and provide early signals for anorexia and cachexia syndrome and suggest mechanism-based interventions to improve the status of cachexia with appropriate nutrients or drugs.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47815752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-11DOI: 10.37290/ctnr2641-452x.21:182-186
V. Štajer, N. Todorovic, Branislava Drdjenovic Conic, N. Kladar, D. Engeset, T. H. Stea, L. Rátgéber, S. Forbes, D. Candow, S. Ostojić
The main aim of this randomized controlled pilot trial was to evaluate the effects of hydrogen-rich water on spermiogram parameters in normospermic and oligospermic men. As many as 12 healthy young men (age 29.1 ± 5.9 years; n = 6 normospermic; n = 6 oligospermic) volunteered. Participants were allocated in a double-blind manner to receive 1 L of hydrogen-rich water per day or 1 L of tap water fortified with magnesium for 8 weeks. Following hydrogen-rich water supplementation, sperm concentration and morphology tended to increase by 12.4 million per milliliter (95% CI; –31.8 to 56.6), and live cells increased by 3.8% (95% CI; –12.5 to 20.1), respectively (P ≤ 0.30). A significant difference between the two interventions was found in sperm vitality (P = 0.03), with hydrogen-rich water being superior to the placebo in terms of an increase in the number of live sperm cells. Subgroup analyses revealed no significant differences between interventions in sperm viability outcomes in oligospermic men (P > 0.05). However, sperm count increased by over 20 million in two of the three oligospermic men (66.7%) receiving hydrogen-rich water, while no oligospermic men in the placebo group increased sperm concentration to euspermic levels (P < 0.01). These preliminary findings suggest hydrogen-rich water is an effective intervention for improving some aspects of male subfertility; further large-sample trials are warranted to corroborate our results.
{"title":"The Effects of Medium-Term Intake of Hydrogen-Rich Water on Sperm Quality Biomarkers in Normospermic and Oligospermic Men: A Randomized Controlled Pilot Trial","authors":"V. Štajer, N. Todorovic, Branislava Drdjenovic Conic, N. Kladar, D. Engeset, T. H. Stea, L. Rátgéber, S. Forbes, D. Candow, S. Ostojić","doi":"10.37290/ctnr2641-452x.21:182-186","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.21:182-186","url":null,"abstract":"The main aim of this randomized controlled pilot trial was to evaluate the effects of hydrogen-rich water on spermiogram parameters in normospermic and oligospermic men. As many as 12 healthy young men (age 29.1 ± 5.9 years; n = 6 normospermic; n = 6 oligospermic) volunteered. Participants were allocated in a double-blind manner to receive 1 L of hydrogen-rich water per day or 1 L of tap water fortified with magnesium for 8 weeks. Following hydrogen-rich water supplementation, sperm concentration and morphology tended to increase by 12.4 million per milliliter (95% CI; –31.8 to 56.6), and live cells increased by 3.8% (95% CI; –12.5 to 20.1), respectively (P ≤ 0.30). A significant difference between the two interventions was found in sperm vitality (P = 0.03), with hydrogen-rich water being superior to the placebo in terms of an increase in the number of live sperm cells. Subgroup analyses revealed no significant differences between interventions in sperm viability outcomes in oligospermic men (P > 0.05). However, sperm count increased by over 20 million in two of the three oligospermic men (66.7%) receiving hydrogen-rich water, while no oligospermic men in the placebo group increased sperm concentration to euspermic levels (P < 0.01). These preliminary findings suggest hydrogen-rich water is an effective intervention for improving some aspects of male subfertility; further large-sample trials are warranted to corroborate our results.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42593532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gastric cancer is a common malignancy with a poor survival rate. Plantamajoside, a phenylethanoid glycoside from Plantago asiatica, has been shown to inhibit the progression of many different types of cancer; however, its effect on gastric cancer remains to be explored. To this end, the effect of plantamajoside on the proliferation, apoptosis, stemness, mobility, and invasion of gastric cancer was evaluated by cell survival assay, flow cytometry, colony formation, sphere formation, transwell, and Western blot assays. Also, the potential molecular mechanism was addressed by Western blot assays for the expression of various signal proteins. Plantamajoside reduced cell viability, enhanced apoptosis, reduced cell mobility, and increased invasion of both AGS and HS746T cells in a dose-dependent manner. Plantamajoside also decreased the diameter of the spheroid and the relative expression of octamer-binding transcription factor-4 and the cluster of differentiation 44 proteins in both AGS and HS746T cells. Furthermore, plantamajoside downregulated the relative protein levels of p-PI3K/ PI3K, p-AKT/AKT, and p-ERK/ERK in both AGS and HS746T cells.
{"title":"Plantamajoside Reduces Gastric Cancer Cell Migration and Invasion by Inhibiting PI3K/AKT and ERK Pathways","authors":"Cheng-fang Tang, Yuanyuan Wang, Jing Huang, Xiaohong Lv","doi":"10.37290/ctnr2641-452x.21:175-181","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.21:175-181","url":null,"abstract":"Gastric cancer is a common malignancy with a poor survival rate. Plantamajoside, a phenylethanoid glycoside from Plantago asiatica, has been shown to inhibit the progression of many different types of cancer; however, its effect on gastric cancer remains to be explored. To this end, the effect of plantamajoside on the proliferation, apoptosis, stemness, mobility, and invasion of gastric cancer was evaluated by cell survival assay, flow cytometry, colony formation, sphere formation, transwell, and Western blot assays. Also, the potential molecular mechanism was addressed by Western blot assays for the expression of various signal proteins. Plantamajoside reduced cell viability, enhanced apoptosis, reduced cell mobility, and increased invasion of both AGS and HS746T cells in a dose-dependent manner. Plantamajoside also decreased the diameter of the spheroid and the relative expression of octamer-binding transcription factor-4 and the cluster of differentiation 44 proteins in both AGS and HS746T cells. Furthermore, plantamajoside downregulated the relative protein levels of p-PI3K/ PI3K, p-AKT/AKT, and p-ERK/ERK in both AGS and HS746T cells.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42551756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-07DOI: 10.37290/ctnr2641-452x.21:138-143
Soyoung Jang, Soyeon Jang, Jiwon Ko, Eungyung Kim, Hyejin Hyung, Ji Yeong Park, Su-Geun Lim, S. Park, M. Kim, Z. Ryoo
Systemic inflammation caused by infection, surgery, or injury can lead to cognitive decline. Lipopolysaccharides are known as toll-like receptor 4 ligands, which are common to the cell walls of gram-negative bacteria. Activation of toll-like receptor 4 leads to the production of proinflammatory cytokines that subsequently mediate systemic inflammation. Furthermore, induc¬tion of systemic inflammation by lipopolysaccharide injection in mice can affect the brain, including cognitive functions. To investigate the neuroprotective role of gossypetin in systemic inflammation, a mouse hippocampal cell line (HT22) and mice were challenged with lipopolysaccharide. The increase in proinflammatory cytokines and reactive oxygen species caused by lipopolysaccharide treatment in HT22 cells was decreased by gossypetin treatment. To evaluate the protective function against memory impairment, gossypetin was orally administered to C57BL/6J mice receiving lipopolysaccharide injec¬tion. Lipopolysaccharide-induced memory deficit was observed in lipopolysaccharide-only treated group in Y-maze test. However, the group treated with gossypetin and lipopolysaccharide had a diminution in cognitive impairment. Consistent with the behavioral test results, the proinflammatory cytokines were also relatively downregulated in the gossypetin-treated mouse group. To sum up, gossypetin can be protect the neuron cells from inflammation in vitro and prevent the cognitive impairment in mice in vivo.
{"title":"Protection of Neuronal Cells from Lipopolysaccharide-Induced Systemic Inflammation by Gossypetin","authors":"Soyoung Jang, Soyeon Jang, Jiwon Ko, Eungyung Kim, Hyejin Hyung, Ji Yeong Park, Su-Geun Lim, S. Park, M. Kim, Z. Ryoo","doi":"10.37290/ctnr2641-452x.21:138-143","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.21:138-143","url":null,"abstract":"Systemic inflammation caused by infection, surgery, or injury can lead to cognitive decline. Lipopolysaccharides are known as toll-like receptor 4 ligands, which are common to the cell walls of gram-negative bacteria. Activation of toll-like receptor 4 leads to the production of proinflammatory cytokines that subsequently mediate systemic inflammation. Furthermore, induc¬tion of systemic inflammation by lipopolysaccharide injection in mice can affect the brain, including cognitive functions. To investigate the neuroprotective role of gossypetin in systemic inflammation, a mouse hippocampal cell line (HT22) and mice were challenged with lipopolysaccharide. The increase in proinflammatory cytokines and reactive oxygen species caused by lipopolysaccharide treatment in HT22 cells was decreased by gossypetin treatment. To evaluate the protective function against memory impairment, gossypetin was orally administered to C57BL/6J mice receiving lipopolysaccharide injec¬tion. Lipopolysaccharide-induced memory deficit was observed in lipopolysaccharide-only treated group in Y-maze test. However, the group treated with gossypetin and lipopolysaccharide had a diminution in cognitive impairment. Consistent with the behavioral test results, the proinflammatory cytokines were also relatively downregulated in the gossypetin-treated mouse group. To sum up, gossypetin can be protect the neuron cells from inflammation in vitro and prevent the cognitive impairment in mice in vivo.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47818170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-07DOI: 10.37290/ctnr2641-452x.21:131-137
Miao Zhang, Dan-dan Huang, Dan Chen, Taotao Hu
Diabetic nephropathy is the major cause of chronic kidney disease worldwide. Persistent hyperglycemia plays a causative role in diabetic nephropathy. Physalin A, a steroidal plant-derived bioactive compound known to exhibit anti-inflammatory, anti-tumor, anti-fungal, and analgesic activities, has been widely used in traditional Chinese medicine practice. The present study examined the effect of Physalin A on high-glucose-treated HBZY-1 cells, a cell culture model of diabetic nephropathy. The results show that Physalin A alleviated cell proliferation, oxidative stress, extracellular matrix protein deposition, and insufficient autophagy induced by high glucose through inhibiting the mitogen-activated protein kinase pathway.
{"title":"Physalin A Enhances Autophagy and Suppresses Oxidative Stress Injury and Extracellular Matrix Deposition in Diabetic Nephropathy","authors":"Miao Zhang, Dan-dan Huang, Dan Chen, Taotao Hu","doi":"10.37290/ctnr2641-452x.21:131-137","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.21:131-137","url":null,"abstract":"Diabetic nephropathy is the major cause of chronic kidney disease worldwide. Persistent hyperglycemia plays a causative role in diabetic nephropathy. Physalin A, a steroidal plant-derived bioactive compound known to exhibit anti-inflammatory, anti-tumor, anti-fungal, and analgesic activities, has been widely used in traditional Chinese medicine practice. The present study examined the effect of Physalin A on high-glucose-treated HBZY-1 cells, a cell culture model of diabetic nephropathy. The results show that Physalin A alleviated cell proliferation, oxidative stress, extracellular matrix protein deposition, and insufficient autophagy induced by high glucose through inhibiting the mitogen-activated protein kinase pathway.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41873268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-07DOI: 10.37290/ctnr2641-452x.21:109-116
Jinshen Wang, Chun-qing Bu, Yanyan Wang, Haiyan Ye, Yue Han, Daogang Qin
We have explored the effect of garlicin, a biologically active compound isolated from garlic, on the proliferation and differentiation of HL-60 leukemia cells. To this end, we measured the effect of garlicin on cell proliferation, cell morphology, cell cycle, and the expression cluster of differentiation molecules 11b and 15, B-cell lymphoma 2 protein, and BCL2-associated X proteins. All-trans retinoic acid and arsenic trioxide treatments served as positive controls for comparison. Results show that garlicin significantly inhibited the proliferation of HL-60 cells and blocked most cells in the G0/G1 phase, with an effect stronger than all-trans retinoic acid or arsenic trioxide treatments. The ability to induce cell maturation and differentiation was like that of all-trans retinoic acid, which may play a role by downregulating the expression of B-cell lymphoma 2 protein and upregulating the expression of BCL2-associated X protein. In conclusion, garlicin significantly inhibits the proliferation and induces differentiation of HL-60 cells, and thus it may become a new clinically viable differentiation-inducing agent.
{"title":"Effects of Garlicin on Proliferation and Differentiation of HL-60 Cells","authors":"Jinshen Wang, Chun-qing Bu, Yanyan Wang, Haiyan Ye, Yue Han, Daogang Qin","doi":"10.37290/ctnr2641-452x.21:109-116","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.21:109-116","url":null,"abstract":"We have explored the effect of garlicin, a biologically active compound isolated from garlic, on the proliferation and differentiation of HL-60 leukemia cells. To this end, we measured the effect of garlicin on cell proliferation, cell morphology, cell cycle, and the expression cluster of differentiation molecules 11b and 15, B-cell lymphoma 2 protein, and BCL2-associated X proteins. All-trans retinoic acid and arsenic trioxide treatments served as positive controls for comparison. Results show that garlicin significantly inhibited the proliferation of HL-60 cells and blocked most cells in the G0/G1 phase, with an effect stronger than all-trans retinoic acid or arsenic trioxide treatments. The ability to induce cell maturation and differentiation was like that of all-trans retinoic acid, which may play a role by downregulating the expression of B-cell lymphoma 2 protein and upregulating the expression of BCL2-associated X protein. In conclusion, garlicin significantly inhibits the proliferation and induces differentiation of HL-60 cells, and thus it may become a new clinically viable differentiation-inducing agent.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46568032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-07DOI: 10.37290/ctnr2641-452x.21:169-174
Fuzhe Chen, Lei Liang, Changlong Lu, Chongyu Xu
We have investigated the effect of a combination of Budesonide and Huangqi granules on pulmonary function in children with bronchial asthma. To this end, children diagnosed with bronchial asthma were divided into two treatment groups, one receiving Budesonide alone (the control group) and the other receiving additional Huangqi granules (the study group). The syndrome score, pulmonary and immune function indices, clinical efficacy, and adverse reactions were observed and compared between the two groups. Before treatment, there was no significant difference in any of the measures between the two groups. However, after treatment, all measures were significantly improved in both groups, with a greater improvement in the study group. Also, the difference in the adverse reaction rate between the two groups was insignificant. In conclusion, Huangqi granules combined with Budesonide can effectively improve the clinical symptoms and repair pulmonary function in children with bronchial asthma.
{"title":"Effect of Huangqi Granules Combined with Budesonide on Clinical Indexes, Clinical Efficacy, and Safety in Children with Bronchial Asthma","authors":"Fuzhe Chen, Lei Liang, Changlong Lu, Chongyu Xu","doi":"10.37290/ctnr2641-452x.21:169-174","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.21:169-174","url":null,"abstract":"We have investigated the effect of a combination of Budesonide and Huangqi granules on pulmonary function in children with bronchial asthma. To this end, children diagnosed with bronchial asthma were divided into two treatment groups, one receiving Budesonide alone (the control group) and the other receiving additional Huangqi granules (the study group). The syndrome score, pulmonary and immune function indices, clinical efficacy, and adverse reactions were observed and compared between the two groups. Before treatment, there was no significant difference in any of the measures between the two groups. However, after treatment, all measures were significantly improved in both groups, with a greater improvement in the study group. Also, the difference in the adverse reaction rate between the two groups was insignificant. In conclusion, Huangqi granules combined with Budesonide can effectively improve the clinical symptoms and repair pulmonary function in children with bronchial asthma.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47101632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In the current study, we have evaluated the effect of gum Arabic on cholesterol homeostasis in atherogenic rats. To this end, adult male Wistar rats were treated orally with increasing concentrations of gum Arabic for 6 consecutive weeks, and serum concentrations of markers of cholesterol homeostasis (total cholesterol, low-density lipoprotein, and 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase activity) were evaluated. Treatment of atherogenic rats with gum Arabic improved serum levels of markers of cholesterol homeostasis. Also, gum Arabic did not reveal any harmful effect on the liver tissue of normal control rats, whereas the liver tissue of atherogenic-treated rats showed improvements in healing, inflammation, and necrosis. In conclusion, gum Arabic may serve to improve cholesterol homeostasis in patients with hypercholesterolemia.
{"title":"The Effect of Gum Arabic on Cholesterol Synthesis and Serum Lipids in Atherogenic Rats","authors":"Abuelgassim Omer Abuelgassim, Abeer Al-Otaibi, Seema Zargar","doi":"10.37290/ctnr2641-452x.21:163-168","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.21:163-168","url":null,"abstract":"In the current study, we have evaluated the effect of gum Arabic on cholesterol homeostasis in atherogenic rats. To this end, adult male Wistar rats were treated orally with increasing concentrations of gum Arabic for 6 consecutive weeks, and serum concentrations of markers of cholesterol homeostasis (total cholesterol, low-density lipoprotein, and 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase activity) were evaluated. Treatment of atherogenic rats with gum Arabic improved serum levels of markers of cholesterol homeostasis. Also, gum Arabic did not reveal any harmful effect on the liver tissue of normal control rats, whereas the liver tissue of atherogenic-treated rats showed improvements in healing, inflammation, and necrosis. In conclusion, gum Arabic may serve to improve cholesterol homeostasis in patients with hypercholesterolemia.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42798398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-07DOI: 10.37290/ctnr2641-452x.21:117-122
W. A. Mumena, May A. Alsayb
This study aimed to investigate the prevalence and determinants of dietary supplement use in Saudi infants and toddlers. A cross-sectional sample of 156 Saudi infants and toddlers and their mothers who reside in Saudi Arabia was recruited via an online survey that was distributed on multiple social media platforms. Data collected include sociodemographic, maternal height and weight, feeding practices, types, initiation, and frequency of supplements use in infants and toddlers. Sixty-three percent of the infants and toddlers included in this study were using dietary supplements. Over three-quarters of the breastfed infants and toddlers were on dietary supplements. All infants and toddlers who were taking dietary supplements used vitamin D; yet, the use of multivitamins and minerals, iron, and vitamin C supplements was not frequently reported. The use of supplements was significantly higher among infants and toddlers who were the only children in the family and had younger and unemployed mothers. Interventions that target increasing maternal awareness concerning the importance of supplement use among young children in Saudi Arabia are needed.
{"title":"Prevalence and Determinants of Dietary Supplements Use Among Saudi Infants and Toddlers","authors":"W. A. Mumena, May A. Alsayb","doi":"10.37290/ctnr2641-452x.21:117-122","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.21:117-122","url":null,"abstract":"This study aimed to investigate the prevalence and determinants of dietary supplement use in Saudi infants and toddlers. A cross-sectional sample of 156 Saudi infants and toddlers and their mothers who reside in Saudi Arabia was recruited via an online survey that was distributed on multiple social media platforms. Data collected include sociodemographic, maternal height and weight, feeding practices, types, initiation, and frequency of supplements use in infants and toddlers. Sixty-three percent of the infants and toddlers included in this study were using dietary supplements. Over three-quarters of the breastfed infants and toddlers were on dietary supplements. All infants and toddlers who were taking dietary supplements used vitamin D; yet, the use of multivitamins and minerals, iron, and vitamin C supplements was not frequently reported. The use of supplements was significantly higher among infants and toddlers who were the only children in the family and had younger and unemployed mothers. Interventions that target increasing maternal awareness concerning the importance of supplement use among young children in Saudi Arabia are needed.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43750949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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