Pub Date : 2023-07-07DOI: 10.37290/ctnr2641-452x.21:254-259
Weiwei Luo, Dongjie Zhu, Yang Yang, Hongxia Li, Jianfeng Jin, Juanjuan Cai
Although amarogentin has been shown to play an amelioration role in several disease states, its role in osteoarthritis progression remains unexplored. To this end, we have examined the role of amarogentin in interleukin-1β-treated chondrocytes, a cell model of osteoarthritis. We observed that chondrocyte proliferation was attenuated after interleukin-1β treatment, which was reversed by amarogentin treatment. In addition, the protein expressions for matrix metalloproteinase-3 and matrix metalloproteinase-9 were enhanced, and collagen II was reduced after interleukin-1β treatment, but these changes were reversed by amarogentin treatment, indicating that amarogentin inhibited interleukin-1β-stimulated extracellular matrix degradation. Moreover, amarogentin strengthened interleukin-1β-triggered chondrocyte autophagy by enhancing LC3II/LC3I, Beclin1, and Atg7 levels and reducing the level of P62, a cargo adaptor protein that interacts with autophagic substrates and delivers them to autophagosomes for degradation. Besides, the expressions of p-AMPK/AMPK and SIRT1 proteins were diminished after interleukin-1β treatment, but these effects were restored by amarogentin treatment, illustrating that amarogentin activated the AMPK/SIRT1 pathway. In conclusion, amarogentin alleviates osteoarthritis by regulating chondrocyte proliferation and autophagy through the AMPK/SIRT1 pathway.
{"title":"Amarogentin Alleviates Osteoarthritis by Regulating Chondrocyte Proliferation and Autophagy","authors":"Weiwei Luo, Dongjie Zhu, Yang Yang, Hongxia Li, Jianfeng Jin, Juanjuan Cai","doi":"10.37290/ctnr2641-452x.21:254-259","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.21:254-259","url":null,"abstract":"Although amarogentin has been shown to play an amelioration role in several disease states, its role in osteoarthritis progression remains unexplored. To this end, we have examined the role of amarogentin in interleukin-1β-treated chondrocytes, a cell model of osteoarthritis. We observed that chondrocyte proliferation was attenuated after interleukin-1β treatment, which was reversed by amarogentin treatment. In addition, the protein expressions for matrix metalloproteinase-3 and matrix metalloproteinase-9 were enhanced, and collagen II was reduced after interleukin-1β treatment, but these changes were reversed by amarogentin treatment, indicating that amarogentin inhibited interleukin-1β-stimulated extracellular matrix degradation. Moreover, amarogentin strengthened interleukin-1β-triggered chondrocyte autophagy by enhancing LC3II/LC3I, Beclin1, and Atg7 levels and reducing the level of P62, a cargo adaptor protein that interacts with autophagic substrates and delivers them to autophagosomes for degradation. Besides, the expressions of p-AMPK/AMPK and SIRT1 proteins were diminished after interleukin-1β treatment, but these effects were restored by amarogentin treatment, illustrating that amarogentin activated the AMPK/SIRT1 pathway. In conclusion, amarogentin alleviates osteoarthritis by regulating chondrocyte proliferation and autophagy through the AMPK/SIRT1 pathway.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69758159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-07DOI: 10.37290/ctnr2641-452x.21:260-265
Hua Wang, Yanan Ji, Chuanju Liu, Jie Gao, Junjiao Hu
Inhalation of the anesthetic sevoflurane leads to neuronal apoptosis, oxidative stress, and cognitive disorders, resulting in post-operative cognitive dysfunction. Hispolon, a natural polyphenol from Phellinus linteus, has been reported to exhibit anticancer, antidiabetic, antioxidant, antiviral, and anti-inflammatory activities. However, its functions in modulating sevoflurane-stimulated neuronal toxicity remain to be examined. To this end, using sevoflurane-treated HT22 cells as a model of postoperative cognitive dysfunction, we have examined the effect of hispolon. Our results show a diminution of the sevoflurane-induced rise in mitochondrial dysfunction, oxidative stress, cell toxicity, and apoptosis in HT22 cells by hispolon. In conclusion, these data suggest that hispolon may be a potential drug for treating postoperative cognitive dysfunction.
{"title":"Protective Effect of Hispolon on Postoperative Cognitive Dysfunction in a Sevoflurane-Induced HT-22 Cell Model","authors":"Hua Wang, Yanan Ji, Chuanju Liu, Jie Gao, Junjiao Hu","doi":"10.37290/ctnr2641-452x.21:260-265","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.21:260-265","url":null,"abstract":"Inhalation of the anesthetic sevoflurane leads to neuronal apoptosis, oxidative stress, and cognitive disorders, resulting in post-operative cognitive dysfunction. Hispolon, a natural polyphenol from Phellinus linteus, has been reported to exhibit anticancer, antidiabetic, antioxidant, antiviral, and anti-inflammatory activities. However, its functions in modulating sevoflurane-stimulated neuronal toxicity remain to be examined. To this end, using sevoflurane-treated HT22 cells as a model of postoperative cognitive dysfunction, we have examined the effect of hispolon. Our results show a diminution of the sevoflurane-induced rise in mitochondrial dysfunction, oxidative stress, cell toxicity, and apoptosis in HT22 cells by hispolon. In conclusion, these data suggest that hispolon may be a potential drug for treating postoperative cognitive dysfunction.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46545514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-07DOI: 10.37290/ctnr2641-452x.21:266-271
Xiao Zhang, Y. Liu, Debo Xu, Lin Li, Zhenyu Liang, Q. Meng, Xihua Huang
We have investigated the efficacy and safety of different maintenance doses of caffeine citrate in the treatment of primary apnea in preterm infants. To this end, apneic premature infants were treated with 5 mg/kg (low dose) or 10 mg/kg (high dose) caffeine citrate, and the frequency of apnea at 48 h and 72 h, improvement of clinical symptoms, respiratory mechanics parameters related to lung function, and blood gas analysis indexes were compared between the two groups, and safety was evaluated. The frequency of apnea at 48 h and 72 h was significantly lower in the high-dose group than in the low-dose group, and the difference was statistically significant (P < 0.05). The time to resolution of apnea, the time to mechanical ventilation, and the time to citrate use were significantly shorter in the high-dose group than in the low-dose group (P < 0.05). The tidal volume and peak expiratory flow values were significantly higher in the high-dose group than in the low-dose group (P < 0.05). The oxygen partial pressure and pulse oximetry levels in the blood gas analysis indexes of the high-dose group were significantly higher than those of the low-dose group, and the partial pressure of carbon dioxide level was significantly lower than that of the low-dose group, with statistically significant differences (P < 0.05). The safety evaluation results showed no significant difference in the rate of adverse reactions and short-term complications between the high-dose group and the low-dose group (P > 0.05). Caffeine citrate at a maintenance dose of 10 mg/kg can effectively reduce the frequency of apnea, shorten the improvement time of clinical symptoms, and improve the lung function and blood gas analysis level of children with a high safety profile.
{"title":"Efficacy and Safety Evaluation of Different Maintenance Dose Regimens of Caffeine Citrate in the Treatment of Primary Apnea in Preterm Infants","authors":"Xiao Zhang, Y. Liu, Debo Xu, Lin Li, Zhenyu Liang, Q. Meng, Xihua Huang","doi":"10.37290/ctnr2641-452x.21:266-271","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.21:266-271","url":null,"abstract":"We have investigated the efficacy and safety of different maintenance doses of caffeine citrate in the treatment of primary apnea in preterm infants. To this end, apneic premature infants were treated with 5 mg/kg (low dose) or 10 mg/kg (high dose) caffeine citrate, and the frequency of apnea at 48 h and 72 h, improvement of clinical symptoms, respiratory mechanics parameters related to lung function, and blood gas analysis indexes were compared between the two groups, and safety was evaluated. The frequency of apnea at 48 h and 72 h was significantly lower in the high-dose group than in the low-dose group, and the difference was statistically significant (P < 0.05). The time to resolution of apnea, the time to mechanical ventilation, and the time to citrate use were significantly shorter in the high-dose group than in the low-dose group (P < 0.05). The tidal volume and peak expiratory flow values were significantly higher in the high-dose group than in the low-dose group (P < 0.05). The oxygen partial pressure and pulse oximetry levels in the blood gas analysis indexes of the high-dose group were significantly higher than those of the low-dose group, and the partial pressure of carbon dioxide level was significantly lower than that of the low-dose group, with statistically significant differences (P < 0.05). The safety evaluation results showed no significant difference in the rate of adverse reactions and short-term complications between the high-dose group and the low-dose group (P > 0.05). Caffeine citrate at a maintenance dose of 10 mg/kg can effectively reduce the frequency of apnea, shorten the improvement time of clinical symptoms, and improve the lung function and blood gas analysis level of children with a high safety profile.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43241078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-07DOI: 10.37290/ctnr2641-452x.21:277-282
Ju-fang Jiang, Xiaofen Shi, Yan Wu
The objective of this study was to probe the effect of comprehensive nutritional nursing on elderly patients with chronic obstructive pulmonary disease. To this end, a total of 82 elderly patients with chronic obstructive pulmonary disease were randomly divided equally into control (receiving conventional treatment) and nursing intervention (receiving conventional treatment and dietary nursing intervention) groups. The body mass index, forced expiratory volume in one second/forced vital capacity, plasma albumin, prealbumin, and hemoglobin levels in the observation group were higher in comparison with the control group. However, the self-rating anxiety scale and self-rating depression scale scores in the observation group were diminished compared to the control group. The scores of psychological, physiological, environmental, and social relations in the observation group were higher relative to the control group. The nursing satisfaction in the observation group was elevated compared to the control group. In conclusion, comprehensive nutritional nursing interventions can improve nutritional status, lung function, and quality of life in elderly patients with chronic obstructive pulmonary disease.
{"title":"Comprehensive Nutritional Nursing Intervention in Elderly Patients with Chronic Obstructive Pulmonary Disease","authors":"Ju-fang Jiang, Xiaofen Shi, Yan Wu","doi":"10.37290/ctnr2641-452x.21:277-282","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.21:277-282","url":null,"abstract":"The objective of this study was to probe the effect of comprehensive nutritional nursing on elderly patients with chronic obstructive pulmonary disease. To this end, a total of 82 elderly patients with chronic obstructive pulmonary disease were randomly divided equally into control (receiving conventional treatment) and nursing intervention (receiving conventional treatment and dietary nursing intervention) groups. The body mass index, forced expiratory volume in one second/forced vital capacity, plasma albumin, prealbumin, and hemoglobin levels in the observation group were higher in comparison with the control group. However, the self-rating anxiety scale and self-rating depression scale scores in the observation group were diminished compared to the control group. The scores of psychological, physiological, environmental, and social relations in the observation group were higher relative to the control group. The nursing satisfaction in the observation group was elevated compared to the control group. In conclusion, comprehensive nutritional nursing interventions can improve nutritional status, lung function, and quality of life in elderly patients with chronic obstructive pulmonary disease.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45591690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-07DOI: 10.37290/ctnr2641-452x.21:228-234
Xingjie Guo, Zhen Zhang, Huairui Li, A. Ho
We aimed to explore the effect of an intravenous infusion of lidocaine combined with ulinastatin on perioperative analgesia and recovery for pancreatic cancer patients undergoing laparoscopic surgery. Postoperative extubation time, time of stay in the recovery room after anesthesia, gastrointestinal function recovery time, and hospital stay in the observation group were all lower in the group receiving ulinastatin. Also, there was a decrease in the Visual Analogue Scale scores for pain at rest and cough in the group receiving ulinastatin. The serum levels of pro-inflammatory cytokines interleukin-6, interleukin-8, and tumor necrosis factor-α were lower in the group receiving ulinastatin. In summary, ulinastatin improves the effect of lidocaine on perioperative analgesia and postoperative recovery of pancreatic cancer without additional side effects during laparoscopic-assisted surgery.
{"title":"Ulinastatin, A Multivalent Serine Protease Inhibitor, Improves Recovery of Pancreatic Cancer Patients Undergoing Laparoscopic Surgery","authors":"Xingjie Guo, Zhen Zhang, Huairui Li, A. Ho","doi":"10.37290/ctnr2641-452x.21:228-234","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.21:228-234","url":null,"abstract":"We aimed to explore the effect of an intravenous infusion of lidocaine combined with ulinastatin on perioperative analgesia and recovery for pancreatic cancer patients undergoing laparoscopic surgery. Postoperative extubation time, time of stay in the recovery room after anesthesia, gastrointestinal function recovery time, and hospital stay in the observation group were all lower in the group receiving ulinastatin. Also, there was a decrease in the Visual Analogue Scale scores for pain at rest and cough in the group receiving ulinastatin. The serum levels of pro-inflammatory cytokines interleukin-6, interleukin-8, and tumor necrosis factor-α were lower in the group receiving ulinastatin. In summary, ulinastatin improves the effect of lidocaine on perioperative analgesia and postoperative recovery of pancreatic cancer without additional side effects during laparoscopic-assisted surgery.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41577065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A total of 120 patients admitted to affiliated hospitals of the North Sichuan Medical College between September 2020 and June 2022 were recruited for this study and received percutaneous transhepatic cholangial drainage. Patients in the control group received parenteral nutrition support, whereas patients in the treatment group received parenteral and combined enteral nutrition support. Compared to the control group, the time of first exhaustion and defecation in the treatment group was faster, and the postoperative activity time and hospital stay were shorter. Serum albumin and prealbumin levels in both groups decreased on the 1st day after surgery and recovered on the 7th day, with the treatment group reaching higher levels. After surgery, the decline in alanine aminotransferase, aspartate aminotransferase, total bilirubin, and direct bilirubin levels was higher in the treatment group. CD4+, CD8+ levels, and CD4+/CD8+ ratios in both groups were elevated, with the treatment group showing higher levels. The occurrence of complications in the treatment group was lessened relative to the control group. In summary, enteral combined parenteral nutrition support for patients with malignant obstructive jaundice after surgery can promote faster recovery of gastrointestinal function, improve nutritional status, facilitate the recovery of liver function, and promote immune function.
{"title":"A Combination of Enteral and Parenteral Nutrition Better Supports Postoperative Prognosis of Patients with Malignant Obstructive Jaundice","authors":"Fang Liu, Chuang Yang, Caixia Hou, Yun Ai, Yuqin Chen","doi":"10.37290/ctnr2641-452x.21:400-404","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.21:400-404","url":null,"abstract":"A total of 120 patients admitted to affiliated hospitals of the North Sichuan Medical College between September 2020 and June 2022 were recruited for this study and received percutaneous transhepatic cholangial drainage. Patients in the control group received parenteral nutrition support, whereas patients in the treatment group received parenteral and combined enteral nutrition support. Compared to the control group, the time of first exhaustion and defecation in the treatment group was faster, and the postoperative activity time and hospital stay were shorter. Serum albumin and prealbumin levels in both groups decreased on the 1st day after surgery and recovered on the 7th day, with the treatment group reaching higher levels. After surgery, the decline in alanine aminotransferase, aspartate aminotransferase, total bilirubin, and direct bilirubin levels was higher in the treatment group. CD4+, CD8+ levels, and CD4+/CD8+ ratios in both groups were elevated, with the treatment group showing higher levels. The occurrence of complications in the treatment group was lessened relative to the control group. In summary, enteral combined parenteral nutrition support for patients with malignant obstructive jaundice after surgery can promote faster recovery of gastrointestinal function, improve nutritional status, facilitate the recovery of liver function, and promote immune function.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":"18 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139362378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-12DOI: 10.37290/ctnr2641-452x.21:440-447
Jie Lin, Ting Zheng, Jiahui Guan, Feiyan Wang
Our research aimed to analyze the application and outcome of several common antiviral drugs and the traditional Chinese medicine formulations for COVID-19 during the early months (January 20, 2020 to December 30, 2020) of the epidemics in China. Patients were clinically classified into mild, common, severe, and critical types based on their clinical symptoms, pulmonary imaging findings, and complications. During the study period, antiviral treatment was administered to 482 patients, with 342 patients receiving a combination of traditional Chinese and Western medicine, accounting for 80.60% and 57.19% of the discharged COVID-19 patients (598 cases), respectively. The main treatment consisted of monotherapy with lopinavir/ ritonavir, arbidol, and chloroquine phosphate, with a need to change the treatment regimen in 29.88% of patients. Three traditional Chinese medicine formulations—Huoxiangzhengqi Liquid, Lianhuaqingwen Jiaonang, and Shufeng Jiedu Jiaonang—were used for COVID-19 treatment and showed good curing effects for patients with mild common clinical classification. Antiviral-related adverse effects were experienced by a total of 142 patients (29.46%). To sum up, antiviral and TCM treatments remain the mainstays of therapy for COVID-19 and show good effects.
{"title":"Evaluation of Clinical Management of COVID-19 Patients in China in the Year 2020","authors":"Jie Lin, Ting Zheng, Jiahui Guan, Feiyan Wang","doi":"10.37290/ctnr2641-452x.21:440-447","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.21:440-447","url":null,"abstract":"Our research aimed to analyze the application and outcome of several common antiviral drugs and the traditional Chinese medicine formulations for COVID-19 during the early months (January 20, 2020 to December 30, 2020) of the epidemics in China. Patients were clinically classified into mild, common, severe, and critical types based on their clinical symptoms, pulmonary imaging findings, and complications. During the study period, antiviral treatment was administered to 482 patients, with 342 patients receiving a combination of traditional Chinese and Western medicine, accounting for 80.60% and 57.19% of the discharged COVID-19 patients (598 cases), respectively. The main treatment consisted of monotherapy with lopinavir/ ritonavir, arbidol, and chloroquine phosphate, with a need to change the treatment regimen in 29.88% of patients. Three traditional Chinese medicine formulations—Huoxiangzhengqi Liquid, Lianhuaqingwen Jiaonang, and Shufeng Jiedu Jiaonang—were used for COVID-19 treatment and showed good curing effects for patients with mild common clinical classification. Antiviral-related adverse effects were experienced by a total of 142 patients (29.46%). To sum up, antiviral and TCM treatments remain the mainstays of therapy for COVID-19 and show good effects.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":"188 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136369741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The COVID-19 pandemic and its associated restrictions made the concept of home testing increasingly popular. Here, we designed a linear transport unit connected to a paper-based multiplexed colorimetric platform, which can be used to test for food safety and physiological status. The device is composed of a linear transport unit and a paper-based multiplexed colorimetric reaction unit. The linear transporting unit uses the capillary phenomenon to collect samples, and the multiplexed colorimetric reaction unit can be used to detect different targets using a hydrophilic area and wax as the hydrophobic barrier. A rapid and multiplexed naked-eye readout of the colorimetric response is achieved in a few minutes. In this study, we demonstrate that the device can be used to detect nitrite, pesticides, lactate, and glycogen. It is a convenient and cheap home self-testing device that can be applied to different situations. This device could lead to earlier screening and, consequently, earlier referrals for further confirmation and treatment.
{"title":"Detection of Carbamates and Nitrites with a Linear Transport Unit Connected to a Paper-Based Multiplexed Colorimetric Platform for Food Safety","authors":"Sung-Yu Wu, Yu-Chien Hung, Kuan-Hung Chen, Connie Chen, Chao-Min Cheng, Min-Yen Hsu","doi":"10.37290/ctnr2641-452x.21:448-453","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.21:448-453","url":null,"abstract":"The COVID-19 pandemic and its associated restrictions made the concept of home testing increasingly popular. Here, we designed a linear transport unit connected to a paper-based multiplexed colorimetric platform, which can be used to test for food safety and physiological status. The device is composed of a linear transport unit and a paper-based multiplexed colorimetric reaction unit. The linear transporting unit uses the capillary phenomenon to collect samples, and the multiplexed colorimetric reaction unit can be used to detect different targets using a hydrophilic area and wax as the hydrophobic barrier. A rapid and multiplexed naked-eye readout of the colorimetric response is achieved in a few minutes. In this study, we demonstrate that the device can be used to detect nitrite, pesticides, lactate, and glycogen. It is a convenient and cheap home self-testing device that can be applied to different situations. This device could lead to earlier screening and, consequently, earlier referrals for further confirmation and treatment.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":"54 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135897627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-05DOI: 10.37290/ctnr2641-452x.21:198-207
Yujuan Cao, Lun Cui
Nicotinamide mononucleotide plays a crucial role in the biosynthesis of the coenzyme nicotinamide adenine dinucleotide, which is involved in various metabolic pathways in all living organisms. Nicotinamide mononucleotide has recently received attention for its potential health benefits in aging, weight loss, diabetes, and as a neuroprotectant. In this study, we aimed to optimize the production of nicotinamide mononucleotide in E. coli with combinations of genes and plasmids. Our results show that nicotinamide mononucleotide production in Escherichia coli is highly related to bacterial growth rate, indicating that the highest nicotinamide mononucleotide production can be achieved by strains with moderate growth rates. This finding highlights the importance of maintaining a balanced growth rate to achieve optimal nicotinamide mononucleotide production in E. coli. Our study provides insights into optimizing the in vivo synthesis of nicotinamide mononucleotide, a potential agent for nutritional supplementation for novel therapies in various age-related diseases.
{"title":"Optimizing Biosynthesis of Nicotinamide Mononucleotide, a Potential Nutritional Supplement, by E. coli","authors":"Yujuan Cao, Lun Cui","doi":"10.37290/ctnr2641-452x.21:198-207","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.21:198-207","url":null,"abstract":"Nicotinamide mononucleotide plays a crucial role in the biosynthesis of the coenzyme nicotinamide adenine dinucleotide, which is involved in various metabolic pathways in all living organisms. Nicotinamide mononucleotide has recently received attention for its potential health benefits in aging, weight loss, diabetes, and as a neuroprotectant. In this study, we aimed to optimize the production of nicotinamide mononucleotide in E. coli with combinations of genes and plasmids. Our results show that nicotinamide mononucleotide production in Escherichia coli is highly related to bacterial growth rate, indicating that the highest nicotinamide mononucleotide production can be achieved by strains with moderate growth rates. This finding highlights the importance of maintaining a balanced growth rate to achieve optimal nicotinamide mononucleotide production in E. coli. Our study provides insights into optimizing the in vivo synthesis of nicotinamide mononucleotide, a potential agent for nutritional supplementation for novel therapies in various age-related diseases.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42327975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-02DOI: 10.37290/ctnr2641-452x.21:1-4
Chien-Ming Lin, Huangfu Chao, Han-Fang Tseng, Chih-Hung Lin, C. Kuo
Chronic kidney disease is characterized by persistent abnormalities in urinary function, structural abnormalities, or impaired excretory functions that indicate the loss of functional nephrons. Cardiovascular disease and death are the most common complications of chronic kidney disease. Once chronic kidney disease is established, treatment has proven ineffective. Therefore, research efforts should be devoted to uncovering early disease mechanisms and alternative treatment options. Traditionally, garlic has been used as a pharmacological agent, especially when aged, in addition to its application as a food flavoring agent. Studies have suggested that garlic has anti-inflammatory and immunomodulatory properties. The effects of garlic on renal function have been summarized in cell culture, animal, and clinical studies.
{"title":"Role of Garlic (Allium Sativum L.) in Chronic Kidney Diseases: A Short Review","authors":"Chien-Ming Lin, Huangfu Chao, Han-Fang Tseng, Chih-Hung Lin, C. Kuo","doi":"10.37290/ctnr2641-452x.21:1-4","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.21:1-4","url":null,"abstract":"Chronic kidney disease is characterized by persistent abnormalities in urinary function, structural abnormalities, or impaired excretory functions that indicate the loss of functional nephrons. Cardiovascular disease and death are the most common complications of chronic kidney disease. Once chronic kidney disease is established, treatment has proven ineffective. Therefore, research efforts should be devoted to uncovering early disease mechanisms and alternative treatment options. Traditionally, garlic has been used as a pharmacological agent, especially when aged, in addition to its application as a food flavoring agent. Studies have suggested that garlic has anti-inflammatory and immunomodulatory properties. The effects of garlic on renal function have been summarized in cell culture, animal, and clinical studies.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41660197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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