Pub Date : 2023-08-04DOI: 10.37290/ctnr2641-452x.21:426-433
Luolin Sha, Qingqing Jiang
This study compared the difference between safflower yellow combined with pitavastatin calcium or with atorvastatin in preventing carotid plaque formation in cerebral infarction patients. Patients with acute cerebral infarction were randomized into groups A and B. Group A received safflower yellow and atorvastatin, while Group B received safflower yellow and pitavastatin calcium for 15 days. Both groups were evaluated for the efficacy of treatment after 6 months. Compared to the group receiving pitavastatin calcium, the atorvastatin group had lower serum total cholesterol, triglycerides, low-density lipoprotein cholesterol, and inflammatory factors, and a higher high-density lipoprotein cholesterol level (P < 0.05). There was no difference in the effect of treatment on other markers such as whole blood viscosity, fibrinogen, and National Institutes of Health Stroke Scale scores (P > 0.05). However, the incidence of adverse reactions was higher in group A than in group B (P < 0.05). To sum up, safflower yellow combined with pitavastatin calcium for cerebral infarction patients can effectively reduce carotid plaque area and improve lipid levels, inflammation, and hemorheology.
{"title":"Safflower Yellow Combined with Pitavastatin Calcium for Preventing Carotid Plaque Formation in Patients with Cerebral Infarction","authors":"Luolin Sha, Qingqing Jiang","doi":"10.37290/ctnr2641-452x.21:426-433","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.21:426-433","url":null,"abstract":"This study compared the difference between safflower yellow combined with pitavastatin calcium or with atorvastatin in preventing carotid plaque formation in cerebral infarction patients. Patients with acute cerebral infarction were randomized into groups A and B. Group A received safflower yellow and atorvastatin, while Group B received safflower yellow and pitavastatin calcium for 15 days. Both groups were evaluated for the efficacy of treatment after 6 months. Compared to the group receiving pitavastatin calcium, the atorvastatin group had lower serum total cholesterol, triglycerides, low-density lipoprotein cholesterol, and inflammatory factors, and a higher high-density lipoprotein cholesterol level (P < 0.05). There was no difference in the effect of treatment on other markers such as whole blood viscosity, fibrinogen, and National Institutes of Health Stroke Scale scores (P > 0.05). However, the incidence of adverse reactions was higher in group A than in group B (P < 0.05). To sum up, safflower yellow combined with pitavastatin calcium for cerebral infarction patients can effectively reduce carotid plaque area and improve lipid levels, inflammation, and hemorheology.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136163483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-03DOI: 10.37290/ctnr2641-452x.21:417-425
Mengting Yu, Xuefen Li, Junxiong Yin, Yan Huang, Zhaomin Xie, Min Wang, Yunyi Li
This study aims to elucidate the effectiveness of gastrodin in improving the outcome of autoimmune encephalitis patients receiving high-dose gamma globulin plus collaborative nursing care. Gastrodin led to higher post-treatment Mini-mental State Examination scores, CD3+, CD4+, IgA, IgG, and IgM than the control group, and lower inflammatory cytokine levels (P < 0.05). To sum up, gastrodin administration to patients receiving high-dose gamma globulin and collaborative nursing care was highly effective in treating autoimmune encephalitis and can effectively improve patients’ quality of life.
{"title":"Gastrodin Improves Quality of Life and Outcome of Autoimmune Encephalitis Treatment with High-Dose Gamma Globulin and Collaborative Care","authors":"Mengting Yu, Xuefen Li, Junxiong Yin, Yan Huang, Zhaomin Xie, Min Wang, Yunyi Li","doi":"10.37290/ctnr2641-452x.21:417-425","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.21:417-425","url":null,"abstract":"This study aims to elucidate the effectiveness of gastrodin in improving the outcome of autoimmune encephalitis patients receiving high-dose gamma globulin plus collaborative nursing care. Gastrodin led to higher post-treatment Mini-mental State Examination scores, CD3+, CD4+, IgA, IgG, and IgM than the control group, and lower inflammatory cytokine levels (P < 0.05). To sum up, gastrodin administration to patients receiving high-dose gamma globulin and collaborative nursing care was highly effective in treating autoimmune encephalitis and can effectively improve patients’ quality of life.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136383995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-02DOI: 10.37290/ctnr2641-452x.21:434-439
Fang Chen, Yingfang Wang, Chen Xu, Hongwei Du, Liuqing Wang
Rheumatoid arthritis is a common immune disease with early symptoms of joint swelling, morning stiffness, pain, and swelling. It could develop into a joint deformity as the disease progresses, resulting in the loss of normal joint function and seriously affecting the patient’s quality of life. Methotrexate is the “anchor drug” for rheumatoid arthritis treatment, which has an immunosuppressive effect and could effectively prevent the abnormal activation of B cells in vivo, inhibit the abnormal generation of cytokines, and relieve related symptoms. However, in some cases, methotrexate alone is not ideal and often needs to be combined with other drugs like xianlinggubao capsules. This study has provided an experimental basis for the combined efficacy of methotrexate and xianlinggubao capsules for female patients with moderate to severe rheumatoid arthritis and their impact on ovarian function.
{"title":"A Combination Therapy of Methotrexate and Xianling Gubao Capsule for Female Patients with Moderate to Severe Active Rheumatoid Arthritis and its Impact on Ovarian Function","authors":"Fang Chen, Yingfang Wang, Chen Xu, Hongwei Du, Liuqing Wang","doi":"10.37290/ctnr2641-452x.21:434-439","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.21:434-439","url":null,"abstract":"Rheumatoid arthritis is a common immune disease with early symptoms of joint swelling, morning stiffness, pain, and swelling. It could develop into a joint deformity as the disease progresses, resulting in the loss of normal joint function and seriously affecting the patient’s quality of life. Methotrexate is the “anchor drug” for rheumatoid arthritis treatment, which has an immunosuppressive effect and could effectively prevent the abnormal activation of B cells in vivo, inhibit the abnormal generation of cytokines, and relieve related symptoms. However, in some cases, methotrexate alone is not ideal and often needs to be combined with other drugs like xianlinggubao capsules. This study has provided an experimental basis for the combined efficacy of methotrexate and xianlinggubao capsules for female patients with moderate to severe rheumatoid arthritis and their impact on ovarian function.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":"98 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135066123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-28DOI: 10.37290/ctnr2641-452x.21:405-410
Yinfang Li, Peiling Yin
We have examined the effect of atomoxetine and Xiaoer Huanglong granules combined with psycho-behavioral modification therapy on attention-deficit/hyperactivity disorder children. Children diagnosed with attention-deficit/hyperactivity disorder were treated with atomoxetine + Xiaoer Huanglong granules (control group) or atomoxetine + Xiaoer Huanglong granules and received psycho-behavioral modification therapy (treatment group). The results show that the treatment group presented a higher overall response rate and a shorter duration of hyperactivity, inattention, and emotional instability than the control group (P < 0.05). After treatment, higher correct scores and serum levels of glial cell line-derived neurotrophic factor, lower error scores and error rate, as well as lower Abbreviated Symptom Questionnaire and Swanson, Nolan, and Pelham, version IV Scale scores, were observed in the treatment group (P < 0.05). Moreover, the incidence of adverse reactions in both groups was similar (P > 0.05). To sum up, atomoxetine, Xiaoer Huanglong granules, and psycho-behavioral modification therapy can effectively improve the learning concentration of attention-deficit/hyperactivity disorder children.
我们观察了阿托西汀、小儿黄龙颗粒联合心理行为矫正治疗对儿童注意缺陷/多动障碍的影响。诊断为注意缺陷/多动障碍的患儿给予阿托西汀+小儿黄龙颗粒治疗(对照组)或阿托西汀+小儿黄龙颗粒治疗，并给予心理行为矫正治疗(治疗组)。结果显示，治疗组总体反应率高于对照组，多动、注意力不集中、情绪不稳定持续时间短于对照组(P <0.05)。治疗后，治疗组神经胶质细胞源性神经营养因子的正确评分和血清水平较高，错误评分和错误率较低，缩短症状问卷和Swanson, Nolan, and Pelham, IV版量表评分较低(P <0.05)。两组不良反应发生率相似(P >0.05)。综上所述，托莫西汀、小儿黄龙颗粒、心理行为矫正疗法能有效提高注意缺陷/多动障碍儿童的学习注意力。
{"title":"Psycho-Behavioral Modification Therapy Enhances the Clinical Efficacy of Atomoxetine and Xiaoer Huanglong Granules Combination in Children with Attention-Deficit/Hyperactivity Disorder","authors":"Yinfang Li, Peiling Yin","doi":"10.37290/ctnr2641-452x.21:405-410","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.21:405-410","url":null,"abstract":"We have examined the effect of atomoxetine and Xiaoer Huanglong granules combined with psycho-behavioral modification therapy on attention-deficit/hyperactivity disorder children. Children diagnosed with attention-deficit/hyperactivity disorder were treated with atomoxetine + Xiaoer Huanglong granules (control group) or atomoxetine + Xiaoer Huanglong granules and received psycho-behavioral modification therapy (treatment group). The results show that the treatment group presented a higher overall response rate and a shorter duration of hyperactivity, inattention, and emotional instability than the control group (P < 0.05). After treatment, higher correct scores and serum levels of glial cell line-derived neurotrophic factor, lower error scores and error rate, as well as lower Abbreviated Symptom Questionnaire and Swanson, Nolan, and Pelham, version IV Scale scores, were observed in the treatment group (P < 0.05). Moreover, the incidence of adverse reactions in both groups was similar (P > 0.05). To sum up, atomoxetine, Xiaoer Huanglong granules, and psycho-behavioral modification therapy can effectively improve the learning concentration of attention-deficit/hyperactivity disorder children.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135608029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-21DOI: 10.37290/ctnr2641-452x.21:315-320
Yinzu Li, Hong Liu, Kuankuan Yang, Xiaoli Tian
We have examined the effect of early enteral nutrition on postoperative recovery as well as the incidence of complications in patients undergoing laparoscopic rectal cancer surgery. The control group received traditional nursing care for postoperative nutrition, whereas the treatment group received early postoperative enteral nutrition. Relative to the control group, the postoperative anal exhaust time, first defecation time, first eating of solid food time, bowel sound recovery time, and hospital stay in the treatment group were shorter (P < 0.05), nutrition-related indexes including serum total protein, albumin, and prealbumin were elevated (P < 0.05), levels of serum inflammatory factors C-reactive protein, interleukin-6, and tumor necrosis factor-α were lower (P < 0.05), peripheral blood CD3+, CD4+, and CD4+/CD8+ cells were elevated, while CD8+ cells were decreased (P < 0.05). The incidence of postoperative complications in the treatment groups was lower relative to the control group (P < 0.05). To sum up, early postoperative enteral nutrition can not only promote the immune function and nutritional status of patients undergoing laparoscopic rectal cancer surgery but also help reduce the postoperative inflammatory response and promote recovery.
{"title":"Early Enteral Nutrition Facilitates Postoperative Recovery and Diminishes Complications in Patients Undergoing Laparoscopic Rectal Cancer Surgery","authors":"Yinzu Li, Hong Liu, Kuankuan Yang, Xiaoli Tian","doi":"10.37290/ctnr2641-452x.21:315-320","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.21:315-320","url":null,"abstract":"We have examined the effect of early enteral nutrition on postoperative recovery as well as the incidence of complications in patients undergoing laparoscopic rectal cancer surgery. The control group received traditional nursing care for postoperative nutrition, whereas the treatment group received early postoperative enteral nutrition. Relative to the control group, the postoperative anal exhaust time, first defecation time, first eating of solid food time, bowel sound recovery time, and hospital stay in the treatment group were shorter (P < 0.05), nutrition-related indexes including serum total protein, albumin, and prealbumin were elevated (P < 0.05), levels of serum inflammatory factors C-reactive protein, interleukin-6, and tumor necrosis factor-α were lower (P < 0.05), peripheral blood CD3+, CD4+, and CD4+/CD8+ cells were elevated, while CD8+ cells were decreased (P < 0.05). The incidence of postoperative complications in the treatment groups was lower relative to the control group (P < 0.05). To sum up, early postoperative enteral nutrition can not only promote the immune function and nutritional status of patients undergoing laparoscopic rectal cancer surgery but also help reduce the postoperative inflammatory response and promote recovery.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46144494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ferroptosis is a regulated cell death implicated in various diseases, including stroke. We have explored the ferroptosis related key genes and the underlying association with acute ischemic stroke. Differentially expressed mRNAs and miRNAs in ischemic stroke were screened based on the GSE16561 and GSE95204 datasets, respectively. Ferroptosis-related genes were downloaded from the FerrDb and GeneCards databases. Eleven ferroptosis-related differentially expressed genes were identified. Based on weighted gene co-expression network analysis, three key modules were identified as being closely associated with stroke. Furthermore, two hub genes, lysosomal associated membrane protein 2 and signal transducer and activator of transcription 3, were selected by a support vector machine-based recursive feature elimination algorithm based on machine learning and showed excellent diagnostic accuracy in stroke, with an area under the curve value of 0.939 and 0.875 in the GSE16561 cohort, respectively. Furthermore, the Comparative Toxicogenomic Database predicted 24 potential therapeutic drugs targeting the two hub genes. To sum up, the identification of hub genes associated with ferroptosis and acute ischemic stroke based on bioinformatics analysis may contribute to the exploration of promising diagnostic and therapeutic biomarkers and provide clues for the prediction of therapeutic candidates.
{"title":"Identification of Ferroptosis-Related Genes in Acute Ischemic Stroke Based on Bioinformatics Analysis and Prediction of Potential Therapeutic Drugs","authors":"Yunze Li, Yangjing Yao, Yan Liu, Qinghua Feng, Yuan Chen, Ying-Yu Lai, Jianjun Li, Minghua Wu","doi":"10.37290/ctnr2641-452x.21:306-314","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.21:306-314","url":null,"abstract":"Ferroptosis is a regulated cell death implicated in various diseases, including stroke. We have explored the ferroptosis related key genes and the underlying association with acute ischemic stroke. Differentially expressed mRNAs and miRNAs in ischemic stroke were screened based on the GSE16561 and GSE95204 datasets, respectively. Ferroptosis-related genes were downloaded from the FerrDb and GeneCards databases. Eleven ferroptosis-related differentially expressed genes were identified. Based on weighted gene co-expression network analysis, three key modules were identified as being closely associated with stroke. Furthermore, two hub genes, lysosomal associated membrane protein 2 and signal transducer and activator of transcription 3, were selected by a support vector machine-based recursive feature elimination algorithm based on machine learning and showed excellent diagnostic accuracy in stroke, with an area under the curve value of 0.939 and 0.875 in the GSE16561 cohort, respectively. Furthermore, the Comparative Toxicogenomic Database predicted 24 potential therapeutic drugs targeting the two hub genes. To sum up, the identification of hub genes associated with ferroptosis and acute ischemic stroke based on bioinformatics analysis may contribute to the exploration of promising diagnostic and therapeutic biomarkers and provide clues for the prediction of therapeutic candidates.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48720443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Danggui Sini decoction is a traditional Chinese medicine preparation commonly used in the treatment of blood stasis syndrome through a mechanism yet to be defined. Therefore, we have explored its mechanism of action by combining pharmacology and gut microbiota analysis. To this end, female Sprague-Dawley rats were divided into 5 groups, including the control group, the acute blood stasis group, the Danshen tablet-treated group, the low-dose Danggui Sini decoction group, and the high-dose Danggui Sini decoction group. Danggui Sini decoction led to a significant reduction in the changes in the whole blood viscosity and plasma viscosity of rats with acute blood stasis syndrome, improved the coagulation function and cardiopulmonary pathological injury, upregulated the plasma 6-keto prostaglandin F1α and endothelial nitric oxide synthase, and downregulated thromboxane B2 and endothelin-1. The high throughput 16S rRNA gene sequencing results showed that Danggui Sini decoction reduced the number of pathogenic proteobacteria, significantly reduced erysipelas and suzericella, and increased the beneficial bacteria Roche, effectively improving the status of intestinal flora disorder in acute blood stasis rats. The Spearman correlation analyses showed that there was a close correlation between intestinal flora distribution and changes in blood stasis-related biochemical indices. In addition, network pharmacological analysis showed that the epidermal growth factor receptor, tumor protein p53, signal transducer and activator of transcription 3, vascular endothelial growth factor A, and hypoxia-inducible factor 1-alpha were the core targets of Danggui Sini decoction in alleviation of blood stasis. Further genetic ontological and pathway enrichment analyses suggested that the therapeutic effect of Danggui Sini decoction on blood stasis involved the lipid and atherosclerosis pathways, advanced glycation end-product-receptor for advanced glycation end-product signaling pathways in diabetic complications, fluid shear stress and atherosclerosis pathways, and hypoxia-inducible factors, 1-alpha signaling pathway, phosphatidylinositol 3-kinase- protein kinase B signaling, and other pathways. These results are helpful in understanding the mechanism by which Danggui Sini decoction improves blood stasis and provide a reference for further research.
{"title":"Combining Gut Microbiota Data with Network Pharmacology to Explore the Mechanism of Danggui Sini Decoction Action Against Blood Stasis Syndrome in Rats","authors":"Fengfeng Yu, Xiaoli Huang, Jiayu Liang, Shuyu Guan","doi":"10.37290/ctnr2641-452x.21:291-305","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.21:291-305","url":null,"abstract":"Danggui Sini decoction is a traditional Chinese medicine preparation commonly used in the treatment of blood stasis syndrome through a mechanism yet to be defined. Therefore, we have explored its mechanism of action by combining pharmacology and gut microbiota analysis. To this end, female Sprague-Dawley rats were divided into 5 groups, including the control group, the acute blood stasis group, the Danshen tablet-treated group, the low-dose Danggui Sini decoction group, and the high-dose Danggui Sini decoction group. Danggui Sini decoction led to a significant reduction in the changes in the whole blood viscosity and plasma viscosity of rats with acute blood stasis syndrome, improved the coagulation function and cardiopulmonary pathological injury, upregulated the plasma 6-keto prostaglandin F1α and endothelial nitric oxide synthase, and downregulated thromboxane B2 and endothelin-1. The high throughput 16S rRNA gene sequencing results showed that Danggui Sini decoction reduced the number of pathogenic proteobacteria, significantly reduced erysipelas and suzericella, and increased the beneficial bacteria Roche, effectively improving the status of intestinal flora disorder in acute blood stasis rats. The Spearman correlation analyses showed that there was a close correlation between intestinal flora distribution and changes in blood stasis-related biochemical indices. In addition, network pharmacological analysis showed that the epidermal growth factor receptor, tumor protein p53, signal transducer and activator of transcription 3, vascular endothelial growth factor A, and hypoxia-inducible factor 1-alpha were the core targets of Danggui Sini decoction in alleviation of blood stasis. Further genetic ontological and pathway enrichment analyses suggested that the therapeutic effect of Danggui Sini decoction on blood stasis involved the lipid and atherosclerosis pathways, advanced glycation end-product-receptor for advanced glycation end-product signaling pathways in diabetic complications, fluid shear stress and atherosclerosis pathways, and hypoxia-inducible factors, 1-alpha signaling pathway, phosphatidylinositol 3-kinase- protein kinase B signaling, and other pathways. These results are helpful in understanding the mechanism by which Danggui Sini decoction improves blood stasis and provide a reference for further research.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41654030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-14DOI: 10.37290/ctnr2641-452x.21:473-477
Qi Liao, Hui Pan, Zhiwu Zheng, Ying Yu
The effects of triple antibiotic therapy plus probiotics on Helicobacter pylori-induced peptic ulcers were assessed. To this end, patients diagnosed with Helicobacter pylori-induced peptic ulcers were divided into control and treatment groups. The control group received standardized triple antibiotic (rabeprazole sodium, amoxicillin, and clarithromycin) therapy, whereas the treatment group also received Compound Eosinophil-Lactobacillus tablets for 14 consecutive days. The treatment outcomes (Helicobacter pylori eradication rate, expression levels of serum procalcitonin, high-sensitivity C-reactive protein, and interleukin-8, and incidence of adverse events) were compared. The effective rate of peptic ulcer control and the eradication rate of Helicobacter pylori were significantly higher for the treatment group than those for the control group (P < 0.05). There was also a significant reduction in pro-inflammatory markers (procalcitonin, high-sensitivity C-reactive protein, and interleukin-8) in the treatment group compared to those in the control group (P < 0.05). Also, the incidence rate of adverse events in the treatment group was lower than that of the control group, but the difference was not statistically significant (P > 0.05). In conclusion, standardized triple antibiotic therapy plus probiotics can effectively improve treatment outcomes and the Helicobacter pylori eradication rate in patients with Helicobacter pylori-induced peptic ulcer.
本研究评估了三联抗生素疗法加益生菌对幽门螺旋杆菌诱发的消化性溃疡的影响。为此，将确诊为幽门螺旋杆菌诱发消化性溃疡的患者分为对照组和治疗组。对照组接受标准化的三联抗生素（雷贝拉唑钠、阿莫西林和克拉霉素）治疗，而治疗组还接受连续 14 天的复方嗜酸乳杆菌片治疗。比较了治疗效果（幽门螺杆菌根除率、血清降钙素原、高敏 C 反应蛋白和白细胞介素-8 的表达水平以及不良反应发生率）。治疗组的消化性溃疡有效控制率和幽门螺杆菌根除率明显高于对照组（P < 0.05）。治疗组的促炎指标（降钙素原、高敏 C 反应蛋白和白细胞介素-8）也明显低于对照组（P < 0.05）。此外，治疗组的不良反应发生率也低于对照组，但差异无统计学意义（P > 0.05）。总之，标准化三联抗生素疗法加益生菌能有效改善幽门螺旋杆菌引起的消化性溃疡患者的治疗效果和幽门螺旋杆菌根除率。
{"title":"Inclusion of Probiotics to Triple Antibiotic Therapy Improves the Outcome of Anti-Helicobacter pylori-Induced Peptic Ulcer","authors":"Qi Liao, Hui Pan, Zhiwu Zheng, Ying Yu","doi":"10.37290/ctnr2641-452x.21:473-477","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.21:473-477","url":null,"abstract":"The effects of triple antibiotic therapy plus probiotics on Helicobacter pylori-induced peptic ulcers were assessed. To this end, patients diagnosed with Helicobacter pylori-induced peptic ulcers were divided into control and treatment groups. The control group received standardized triple antibiotic (rabeprazole sodium, amoxicillin, and clarithromycin) therapy, whereas the treatment group also received Compound Eosinophil-Lactobacillus tablets for 14 consecutive days. The treatment outcomes (Helicobacter pylori eradication rate, expression levels of serum procalcitonin, high-sensitivity C-reactive protein, and interleukin-8, and incidence of adverse events) were compared. The effective rate of peptic ulcer control and the eradication rate of Helicobacter pylori were significantly higher for the treatment group than those for the control group (P < 0.05). There was also a significant reduction in pro-inflammatory markers (procalcitonin, high-sensitivity C-reactive protein, and interleukin-8) in the treatment group compared to those in the control group (P < 0.05). Also, the incidence rate of adverse events in the treatment group was lower than that of the control group, but the difference was not statistically significant (P > 0.05). In conclusion, standardized triple antibiotic therapy plus probiotics can effectively improve treatment outcomes and the Helicobacter pylori eradication rate in patients with Helicobacter pylori-induced peptic ulcer.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":"75 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139359383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-13DOI: 10.37290/ctnr2641-452x.21:454-460
Jian Zeng, Zonghan Zhou
Cistanche is known to relieve cataracts; however, the active ingredients and mechanism of action of cistanche to relieve cataracts are unclear. At present, the active ingredients of cistanche were screened through the Traditional Chinese Medicine Systems Pharmacology website, and a total of six active ingredients were identified. Drug and disease targets were obtained through Swiss target prediction and the Genecard website, and a total of 172 common targets were identified. The biological functions and Kyoto Encyclopedia of Genes and Genomes pathway enrichment of the targets were found to be concentrated in the phosphatidylinositol 3-kinase/protein kinase B, forkhead family of transcription factors, and mitogen-activated protein kinases pathways. The protein–protein interaction network was established, and phosphatidylinositol 3-kinase and protein kinase B-related genes were found to be the key genes. Molecular docking was carried out between the active ingredient and the key target, and it was found that the combination of the active ingredient and the key target was stable. In summary, cistanche can reduce cataracts by regulating the key targets of the active ingredients and thus alleviating cataracts.
{"title":"Network Pharmacology-Based Strategy to Reveal the Mechanism of Action of Cistanche Against Cataracts","authors":"Jian Zeng, Zonghan Zhou","doi":"10.37290/ctnr2641-452x.21:454-460","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.21:454-460","url":null,"abstract":"Cistanche is known to relieve cataracts; however, the active ingredients and mechanism of action of cistanche to relieve cataracts are unclear. At present, the active ingredients of cistanche were screened through the Traditional Chinese Medicine Systems Pharmacology website, and a total of six active ingredients were identified. Drug and disease targets were obtained through Swiss target prediction and the Genecard website, and a total of 172 common targets were identified. The biological functions and Kyoto Encyclopedia of Genes and Genomes pathway enrichment of the targets were found to be concentrated in the phosphatidylinositol 3-kinase/protein kinase B, forkhead family of transcription factors, and mitogen-activated protein kinases pathways. The protein–protein interaction network was established, and phosphatidylinositol 3-kinase and protein kinase B-related genes were found to be the key genes. Molecular docking was carried out between the active ingredient and the key target, and it was found that the combination of the active ingredient and the key target was stable. In summary, cistanche can reduce cataracts by regulating the key targets of the active ingredients and thus alleviating cataracts.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":"222 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139359660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-13DOI: 10.37290/ctnr2641-452x.21:395-399
Weiwei Song, Dandan Zhu, Yinling Zhao
We have explored the efficacy of neoadjuvant chemotherapy in association with cytoreductive surgery and postoperative parenteral nutrition support in advanced ovarian cancer patients. The control group received cytoreductive surgery combined with postoperative conventional chemotherapy and fasted after surgery, whereas the treatment group received neoadjuvant chemotherapy combined with cytoreductive surgery and parenteral nutrition. In contrast to the control group, the operation time, hospital stay, amount of intraoperative blood loss, and abdominal fluid accumulation of the treatment group were diminished, the total effectiveness rate was elevated, serum levels of albumin, transferrin, and prealbumin were increased, levels of human epididymal protein 4, vascular endothelial growth factor, and carbohydrate antigen 125 were declined, and the Karnofky Performance Status score was higher. While there was no difference observed in the 1-year survival rate or total incidence of complications between the two groups, the quality of life of patients in the treatment group improved.
{"title":"Postoperative Parenteral Nutrition Support and Neoadjuvant Chemotherapy Combined with Cytoreductive Surgery Improve the Quality of Life, but Not the Survival Rate or Incidence of Complications","authors":"Weiwei Song, Dandan Zhu, Yinling Zhao","doi":"10.37290/ctnr2641-452x.21:395-399","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.21:395-399","url":null,"abstract":"We have explored the efficacy of neoadjuvant chemotherapy in association with cytoreductive surgery and postoperative parenteral nutrition support in advanced ovarian cancer patients. The control group received cytoreductive surgery combined with postoperative conventional chemotherapy and fasted after surgery, whereas the treatment group received neoadjuvant chemotherapy combined with cytoreductive surgery and parenteral nutrition. In contrast to the control group, the operation time, hospital stay, amount of intraoperative blood loss, and abdominal fluid accumulation of the treatment group were diminished, the total effectiveness rate was elevated, serum levels of albumin, transferrin, and prealbumin were increased, levels of human epididymal protein 4, vascular endothelial growth factor, and carbohydrate antigen 125 were declined, and the Karnofky Performance Status score was higher. While there was no difference observed in the 1-year survival rate or total incidence of complications between the two groups, the quality of life of patients in the treatment group improved.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":"24 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139359917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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