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Comparative Analysis of Antimicrobial Activity of Herbal Extracts against Pathogenic Microbes 中药提取物对病原菌抑菌活性的比较分析
Pub Date : 2018-07-05 DOI: 10.19080/ctbeb.2018.16.555930
P. Agrawal, Divya Kotagiri, Viswanatha Chaitanya Kolluru
Antimicrobial activities of Spinacia oleracealeaf, Zingiberofficinalerhizome, Coriandrum sativum leaf, Allium sativum clove, Aloe vera gel and leaf was carried out against the multi-drug resistant strains using the minimum inhibitory concentration method. The direct TLC bioautography method is performed to identify the bioactive compounds present in the extracts exhibiting the antimicrobial property.All the plant extracts effectively inhibited the growth of pathogenic strains used in the study at a concentration of 250 to 31.25mg/ml. These results provide evidence that the tested plant extracts possess antimicrobial properties which can be tested further in the development of novel antimicrobial agents.
采用最小抑菌浓度法研究了菠菜叶、生姜、芫荽叶、葱瓣、芦荟凝胶和芦荟叶对多重耐药菌株的抑菌活性。采用直接薄层色谱生物自显影法鉴定具有抗菌特性的提取物中存在的生物活性化合物。所有植物提取物在浓度为250 ~ 31.25mg/ml时均能有效抑制本研究所用病原菌的生长。这些结果为所测试的植物提取物具有抗菌特性提供了证据,可以在新型抗菌药物的开发中进一步测试。
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引用次数: 16
The Combination Cyclophosphamide with Radiation Increases Tumour Cure in Ehrlich Ascites Carcinoma Bearing Mice as well as DNA Damage in the Normal Mice Bone Marrow Exposed to Different Doses of Γ-Radiation 环磷酰胺联合放疗提高了患埃利希腹水癌小鼠的肿瘤治愈率,并增加了暴露于不同剂量Γ-Radiation的正常小鼠骨髓DNA损伤
Pub Date : 2018-07-03 DOI: 10.19080/ctbeb.2018.16.555929
Ganesh Chandra Jagetia
Alterations in the radiation-induced micronuclei formation was studied in mice bone marrow treated with 0.5mg/kg body weight (1/500th of the LD50) of cyclophosphamide (CPA) before exposure to 0, 0.5, 1, 2 and 3Gy of γ-radiation. Irradiation of animals caused a dose dependent elevation in the Micro-nucleated Polychromatic Erythrocytes (MPCE) and Micro nucleated Norm chromatic Erythrocytes (MNCE) in the bone marrow of mice at 24h post-irradiation. Treatment of mice with 0.5mg/kg CPA elevated the radiation-induced MPCE significantly up to 2Gy irradiation and showed a significant decline thereafter when compared to the concurrent sterile physiological saline (SPS) treated irradiated group. The frequency of radiation-induced MNCE also showed a significant elevation after CPA treatment at all exposure doses. In a separate experiment the effect of 0.5mg/kg b. wt. CPA was evaluated in combination with radiation in the Ehrlich Ascites Carcinoma bearing mice (EAC). The combination of 0.5mg/kg b. wt. of CPA with 1, 2, 4, 6 and 8Gy of irradiation increased both the Median Survival Time (MST) and Average Survival Time (AST) of the EAC bearing mice when compared with the SPS+ irradiation and the maximum effect was observed in mice that received CPA and 8Gy of radiation. Our study demonstrates that the risk of genomic instability and mutagenesis outweighs the benefit accrued in the tumor bearing mice receiving combination of CPA and ionizing radiation.
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引用次数: 1
Production of Oxalic Acid by Aspergillus niger using Chlorella Vulgaris Grown with an Industrial Effluent as a Potential Feedstock 利用工业废水培养的普通小球藻作为潜在原料,黑曲霉生产草酸
Pub Date : 2018-07-02 DOI: 10.19080/ctbeb.2018.16.555928
Chioma Dm
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引用次数: 0
Applying Social Network Analysis to Understand the Percentages of Keywords within Abstracts of Journals: A System Review of Three Journals 应用社会网络分析了解期刊摘要中关键词的百分比:三种期刊的系统综述
Pub Date : 2018-07-02 DOI: 10.19080/ctbeb.2018.16.555926
W. Chou
Background: Academic literature suggests keywords that are retrieved from a paper’s title and abstract represent important concepts in that study. The percentage of keywords within an abstract (PKWA) is required to investigate. Objective: To compare the PKWA in journals of medical informatics and the keyword network relationship in order to develop a self-examining policy for the journal. Methods: Selecting 5,985 abstracts and their corresponding keywords in three journals (JMIR, JAMIA, and BMC Med Inform Decis Mak.) published between 1995 to 2017(April) on the US National Library of Medicine National Institutes of Health (Pubmed.org), we computed the PKWA for each journal by using MS Excel modules and compared the percentage differences across journals and years via a two-way ANOVA. Social Network Analysis (SNA) was performed to explore the relations of keywords in journals. Results: The PKWA are 48.81, 41.59, and 56.84 for the three journals, respectively. A statistically significant difference (p<0.05) is found in the percentages among journals selected. In contrast, no differences (p>0.05) are found (1) between years (2016 and 2017) and (2) in interaction effects between journals and years. Three journals display significantly different patterns in network keywords and major cohesion measures. Conclusion: It is required to apply the computer module when inspecting whether keywords are within abstracts. The cohesion measure provides journal editors with a method of examining keywords within an abstract for a paper under review. the accompanying abstract requires analysis. The Percentage of Keywords (PKW) within an abstract for a paper can be used to compare journals.
背景:学术文献表明,从论文标题和摘要中检索到的关键词代表了该研究中的重要概念。摘要中关键字的百分比(PKWA)需要进行调查。目的:比较医学信息学期刊的PKWA与关键词网络关系,以制定医学信息学期刊的自查政策。方法:选取1995 - 2017年(4月)美国国家医学图书馆国立卫生研究院(Pubmed.org)期刊(JMIR、JAMIA和BMC Med Inform Decis Mak.) 3种期刊(JMIR、JAMIA和BMC Med Inform Decis Mak.)中发表的5985篇摘要及其相应关键词,采用MS Excel模块计算各期刊的PKWA,并通过双向方差分析比较不同期刊和年份间的百分比差异。运用社会网络分析(Social Network Analysis, SNA)探讨期刊关键词之间的关系。结果:3种期刊的PKWA分别为48.81、41.59和56.84。(1)不同年份(2016年和2017年)和(2)期刊和年份之间的交互效应有统计学显著差异(p0.05)。三种期刊在网络关键词和主要衔接测度上存在显著差异。结论:对摘要是否包含关键词进行检测,需要运用计算机模块。内聚力测量为期刊编辑提供了一种检查论文摘要中关键词的方法。随附的摘要需要分析。论文摘要中的关键词百分比(PKW)可用于比较期刊。
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引用次数: 0
Systematic Review: Effect of Strangle on Health of Equine Animals and its Prevention 系统综述:勒死对马类动物健康的影响及其预防
Pub Date : 2018-07-02 DOI: 10.19080/ctbeb.2018.16.555927
T. Abdisa
Strangle is an infectious and highly contagious respiratory disease of equine which have great impact on the health of equnines. It is caused by streptococcus equi sub sp. equi, a gram positive bacterium in irregular shaped cocci that forms long chain. Strangles occurs worldwide mostly in horses and rarely in donkey and mules. The outbreak of strangle is frequently seen on racing stable, riding and breeding farms when the infection is introduced by new arrivals that are often carrier. Strangle disease affects mostly young horses and outbreak can occur at any time of the year but, most likely to happen in cold weather. The severity of the clinical presentation depends on age, previous infections, vaccination and stabling conditions. Strangle can be transmitted to other equine animals buy direct and in direct ways. The causative agent of strangle, S. equi var equi have great variety of virulence factors that interact with host tissues and components, and favour bacteria colonization and growth. The pathogenesis of strangle disease is begin with nasopharyngeal infection with S. equi var equi follows contact with a shedding carrier horse. The after the bacteria begin to multiply in lymph nodes.
马窒息病是马的一种传染性和高度传染性呼吸道疾病,严重影响马的健康。它是由马链球菌引起的,马链球菌是一种革兰氏阳性细菌,呈不规则形状,形成长链。在世界范围内,绞杀主要发生在马身上,很少发生在驴和骡子身上。在赛马场、赛马场和养殖场,当感染是由通常是带菌者的新来者引入时,经常会出现勒死的爆发。勒死病主要影响年轻的马,疫情可能在一年中的任何时候发生,但最可能发生在寒冷的天气。临床表现的严重程度取决于年龄、既往感染、疫苗接种和病情稳定。绞杀可以通过直接和直接的方式传染给其他马类动物。绞杀的病原体,马链球菌(S. equi var equi)具有多种毒力因子,这些毒力因子与宿主组织和成分相互作用,有利于细菌定植和生长。勒死病的发病机制始于鼻咽感染马链球菌,马链球菌在接触脱落的马后感染。细菌开始在淋巴结中繁殖。
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引用次数: 0
Oral Bacteria Contribution in Wine Flavor Perception 口腔细菌对葡萄酒风味感知的影响
Pub Date : 2018-06-27 DOI: 10.19080/CTBEB.2018.15.555923
Davide Frumento
Abstract
摘要
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引用次数: 3
Child Abuse: Identification and Its Prevention 虐待儿童:识别及其预防
Pub Date : 2018-06-27 DOI: 10.19080/ctbeb.2018.15.555924
Susheelkumar V Ronad
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引用次数: 0
Bio Fertilizers with Organic Manures: a Better Strategy for Sustainable Productivity 生物肥料与有机肥料:可持续生产力的更好策略
Pub Date : 2018-06-25 DOI: 10.19080/ctbeb.2018.15.555921
Waqas Liaqat
One of the major crop productivity constraints in the third world is the unavailability of crop nutrients in appropriate amount and form [1]. Modern agricultural practices emphasize widespread use of fertilizers which certainly increased grain yield in many countries in the last six decades. However, long term use of chemical fertilizers also led to a decline in crop yield and soil fertility in the intensive cropping system [2]. It is evident that over fertilization increases concentration of several plant nutrients in surface as well as ground water, which creates a potential health hazard. This has in turn paved the way for integrated plant nutrient management. The use of renewable resources and inputs is one the fundamental principles of sustainable agriculture that enables maximum crop productivity and minimal environmental risk [3]. Therefore, an increased yield with reduced environmental risk requires new cultivation strategies including biological fertilizer [4]. Bio fertilizer is a natural input that can be applied as a complement to, or as a substituent of chemical fertilizer in sustainable agriculture [5]. Integrated use of biofertilizers with natural manures offer a low capital investment and eco-friendly route to boosting farm productivity [6]. Chemical fertilizers have outstandingly boosted crop yields about three decades back. However, yields are currently getting low or stagnated. Moreover, poor-resource holder farmers in developing countries apply little or no fertilizer due to high cost of procurement.
第三世界的主要作物生产力限制之一是无法获得适当数量和形式的作物养分。现代农业实践强调化肥的广泛使用,在过去的60年里,化肥确实提高了许多国家的粮食产量。然而,在集约种植制度bbb中,长期使用化肥也会导致作物产量和土壤肥力下降。显然,过度施肥会增加地表水和地下水中几种植物养分的浓度,从而造成潜在的健康危害。这反过来又为植物养分综合管理铺平了道路。使用可再生资源和投入是可持续农业的基本原则之一,可实现最大的作物生产力和最小的环境风险。因此,在降低环境风险的情况下提高产量需要新的栽培策略,包括生物肥料。生物肥料是一种天然的投入物,在可持续农业中可以作为化肥的补充或替代品。生物肥料与天然肥料的综合使用为提高农业生产力提供了低资本投资和环保的途径。大约30年前,化肥显著提高了农作物产量。然而,收益率目前正变得越来越低或停滞不前。此外,由于采购成本高,发展中国家资源贫乏的农民很少或不施用肥料。
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引用次数: 0
Pharmacognostic Study of Eranthemum nigrum Stem 菊花茎的生药学研究
Pub Date : 2018-06-22 DOI: 10.19080/ctbeb.2018.15.555916
D. Prasanth
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引用次数: 0
Scaffolds and Tissue Engineering 支架与组织工程
Pub Date : 2018-06-22 DOI: 10.19080/CTBEB.2018.15.555920
G. Subramanyam
Scaffold is a commonly used term for a supporting structure. Similarly scaffolds biologically are extra cellular matrix that support and keep the cells viable by nutritional supply, receptor stimulation and signaling pathways. National foundation in 1998 has coined the term tissue engineering. Tissue engineering is concerned with the development of various biological tissues as an alternative functioning to the normal tissues. Accordingly tissue engineering may be defined as the development of scaffolds or materials with in the cells for the repair of damaged organs or tissue. Tissue engineering assists for the development of structures like vessels, bladder, liver, pancreas skin and muscle etc. Scaffolds are either biodegradable or bio stable. Bio degradable scaffolds highly porous and acts as base or seeding of cells and for growth of tissues and vessels. 3D bio degradable scaffolds are preferable than 2D as the earlier mimics natural environment and a steady state like that of tissues organs. However vascular tissues like bone and cartilage are also developed by tissue engineering.
脚手架是支撑结构的常用术语。生物学上类似的支架是细胞外基质,通过营养供应、受体刺激和信号通路来支持和保持细胞的活力。国家基金会在1998年创造了组织工程这个术语。组织工程关注的是各种生物组织的发展,作为正常组织的替代功能。因此,组织工程可以定义为细胞内支架或材料的开发,用于修复受损的器官或组织。组织工程有助于血管、膀胱、肝脏、胰腺、皮肤和肌肉等结构的发育。支架要么是可生物降解的,要么是生物稳定的。生物可降解支架,高度多孔,作为细胞的基础或种子,用于组织和血管的生长。3D生物可降解支架比2D生物可降解支架更可取,因为3D生物可降解支架模仿自然环境,并且具有类似组织器官的稳定状态。然而,像骨和软骨这样的血管组织也可以通过组织工程来开发。
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Current Trends in Biomedical Engineering & Biosciences
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