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Nanoparticle Treatment of Cancer 纳米粒子治疗癌症
Pub Date : 2018-11-20 DOI: 10.19080/ctbeb.2018.17.555959
Ronald L. Huston
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引用次数: 0
Obesity in Pakistan; Current and Future Perceptions 巴基斯坦的肥胖问题;当前和未来的看法
Pub Date : 2018-11-14 DOI: 10.19080/ctbeb.2018.17.555958
Atif Amin Baig
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引用次数: 27
Transcatheter Cardiovascular Therapeutics (TCT) conference 2018 2018年经导管心血管治疗(TCT)会议
Pub Date : 2018-11-13 DOI: 10.19080/ctbeb.2018.17.555957
S. Datta
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引用次数: 0
Lymphoma no Hodgkin Burkitt’s lymphoma 非霍奇金伯基特淋巴瘤
Pub Date : 2018-11-13 DOI: 10.19080/CTBEB.2018.17.555956
Mirta D’Ambra
lymphoma is a neoplasm that usually affects children and adolescents, in adults it is usually related to HIV. It is considered to be highly malignant due to its rapid replication capacity. If it is detected in early stages, it may have a high degree of remission with chemotherapy, but in cases of late detection, survival is very short. One of its complications is tumor lysis with renal failure and the physio pathological changes that this implies, for example, edema, such as the case presented.It is always important to remember that a good clinical history, a complete physical examination are the pillars of a medical assessment, associated with complementary laboratory tests, cabinet, biopsy, among others, can get to obtain quick and accurate diagnoses that allow treatment initiation timely in order to preserve and improve the quality of life of patients.
淋巴瘤是一种通常影响儿童和青少年的肿瘤,在成人中通常与艾滋病毒有关。由于其快速复制能力,它被认为是高度恶性的。如果在早期发现,它可能有高度的缓解与化疗,但在晚期发现的情况下,生存时间很短。其并发症之一是肿瘤溶解伴肾功能衰竭和生理病理改变,如水肿,如本例所示。重要的是要记住,良好的临床病史,完整的体格检查是医学评估的支柱,与补充实验室检查,橱柜,活检等相结合,可以获得快速准确的诊断,及时开始治疗,以保持和改善患者的生活质量。
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引用次数: 0
Ways to Overcome Emotional and Psychological Trauma in a Day Today Life 在今天的生活中克服情感和心理创伤的方法
Pub Date : 2018-10-30 DOI: 10.19080/ctbeb.2018.17.555955
Susheelkumar V Ronad
Psychological trauma is a sort of harm to the mind that happens because of an extremely troubling occasion. Injury is regularly the after-effect of a staggering measure of pressure that surpasses one’s capacity to adapt, or incorporate the feelings required with that experience [1]. An awful accident includes one’s understanding, or rehashing occasions of being overpowered that can be encouraged in weeks, years, or even a long time as the individual battles to adapt to the prompt conditions, in the end prompting genuine, long haul negative outcomes [2-5].
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引用次数: 0
The Lethal Frequencies of Thunderstorm Sounds and Energies: A Mini Review 雷暴声音和能量的致命频率:一个小回顾
Pub Date : 2018-10-22 DOI: 10.19080/ctbeb.2018.17.555954
Saganuwan Alhaji Saganuwan
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引用次数: 1
Metallic Biomaterials 金属生物材料
Pub Date : 2018-10-12 DOI: 10.19080/ctbeb.2018.17.555953
F. Findik
Due to their superior electrical and thermal conductivity and mechanical properties, metals are used as biomaterials. Some metals are used as an alternative to hard tissue replacement, such as total hip and knee joints. Some metal alloys are used for active roles in devices such as vascular stents, catheter guide wires and cochlear implants. “Vanadium steel” used as a base metallic alloy for human use for bone fracture plates and screws. Most metals (eg Fe, Cr, Co, Ni, Ti, Nb and Mo) are used for alloys used to make implants, which can only be accepted by the body in small quantities.
由于其优越的导电性、导热性和机械性能,金属被用作生物材料。一些金属被用作硬组织替代的替代品,例如整个髋关节和膝关节。一些金属合金用于血管支架、导管导丝和耳蜗植入物等设备的主动作用。“钒钢”作为基本金属合金,用于人体骨折钢板和螺钉。大多数金属(如Fe, Cr, Co, Ni, Ti, Nb和Mo)用于制造植入物的合金,这些合金只能被人体少量接受。
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引用次数: 0
Jojoba oil: Anew media for frying process 荷荷巴油:煎炸过程的新介质
Pub Date : 2018-10-12 DOI: 10.19080/ctbeb.2018.17.555952
Amany M Basuny
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引用次数: 1
The Interplay between Brain-Derived Neurotrophic Factors and Stress Hormone Modulates the Process of Neurogenesis 脑源性神经营养因子与应激激素的相互作用调控神经发生过程
Pub Date : 2018-10-09 DOI: 10.19080/CTBEB.2018.17.555951
N. Saini
Brain-derived neurotrophic factor (BDNF) is molecule that enhances the growth and maintenance of neurons in the central nervous system [1,2]. BDNF is highly expressed in the hippocampal and cortical regions of the brain where they involved in neuronal survival, synaptic plasticity and the formation of long-lasting memories [3-5]. Their high affinity receptor, TrkB has been identified as the Trk family of tyrosine protein kinases, thus facilitate to understand the signaling pathways responsible for mediating their trophic properties [6]. TrkB receptor is phosphorylated by binding of BDNF that trigger the activation of ERK-, Akt-, and PLC gamma-pathways [7-9]. Each pathway contributes to multifarious neuronal functions, including neurogenesis and the regulation of cell fate [10,11]. Various studies demonstrated that reduced expression of BDNF along with depressive behaviors, suggesting that an alteration in status of the BDNF/TrkB system leads to reduction in neurogenesis resulting brain dysfunctioning. Chronic stress reduces mRNA levels of BDNF [10,12] is one of the most important endogenous mediators of stress responses in the mammalian brain. Glucocorticoids (GCs) a stress hormone, exert influence on neurogenesis and functions, as well as BDNF [13]. Blood levels of GCs are regulated by hypothalamus-pituitaryadrenal (HPA) axis activity [14-16]. It is well known that chronic stress induces the hyper activation of HPA axis, resulting overabundance of GCs levels [16]. Elevated levels of GCs have a role in the onset of mental disorders, including post-traumatic stress disorder, major depressive disorders and neurodegeneration. Furthermore, GC stress suppress the formation of neuron synthesis, especially in hippocampal region, has been a vulnerable target to develop new drugs because it shows the dysregulation of HPA axis function [17,18] and is considered as a culprit that leads to the onset of the mental disorders [19]. This review article demonstrated the functional interaction between BDNF and GCs towards altered neurogenesis.
脑源性神经营养因子(Brain-derived neurotrophic factor, BDNF)是中枢神经系统中促进神经元生长和维持的分子[1,2]。BDNF在大脑海马区和皮质区高度表达,参与神经元存活、突触可塑性和持久记忆的形成[3-5]。它们的高亲和力受体TrkB已被确定为酪氨酸蛋白激酶的Trk家族,从而有助于理解负责介导其营养特性的信号通路[6]。TrkB受体通过与BDNF结合而磷酸化,从而激活ERK-、Akt-和PLC γ通路[7-9]。每条通路都参与多种神经元功能,包括神经发生和细胞命运的调节[10,11]。各种研究表明,BDNF的表达减少伴随着抑郁行为,这表明BDNF/TrkB系统状态的改变导致神经发生减少,从而导致脑功能障碍。慢性应激可降低BDNF mRNA水平[10,12],BDNF是哺乳动物大脑中最重要的内源性应激反应介质之一。糖皮质激素(Glucocorticoids, GCs)是一种应激激素,对神经发生和功能以及BDNF都有影响[13]。GCs的血药浓度受下丘脑-垂体-肾上腺(HPA)轴活性的调节[14-16]。众所周知,慢性应激诱导HPA轴过度激活,导致GCs水平过高[16]。GCs水平升高与精神障碍的发病有关,包括创伤后应激障碍、重度抑郁症和神经退行性疾病。此外,GC应激抑制神经元合成的形成,特别是海马区神经元合成的形成,表现出HPA轴功能失调[17,18],被认为是导致精神障碍发病的罪魁祸首[19],因此成为新药开发的一个脆弱靶点。本文综述了BDNF和GCs对神经发生改变的功能相互作用。
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引用次数: 0
Ill Effects of Technology: Dehiscence Encountered Following Laser Depigmentation: A Case Report 技术的不良影响:激光脱色后出现的开裂:1例报告
Pub Date : 2018-10-09 DOI: 10.19080/CTBEB.2018.16.555949
Anamika Sharma
An alveolar dehiscence denotes a lack of the facial or lingual alveolar cortical plate resulting in a denuded root surface, while an alveolar fenestration is a circumscribed defect of the cortical plate which exposes the underlying root surface, not involving the marginal bone [1]. Deformities of the alveolar process can present surgical dilemmas which are technically demanding and may seriously affect the outcome of treatment [2]. The overall prevalence ranges from 0.99 to 13.4% for dehiscences and 0.23% to 16.9% for fenestrations. Elliott & Bowers [3] reported that alveolar dehiscences and fenestrations were associated with 9.19% and 10.93%, respectively.
牙槽开裂是指缺乏面牙槽或舌牙槽皮质板,导致根表面脱落,而牙槽开孔是皮质板的局限缺陷,暴露下根表面,不包括边缘骨bbb。牙槽突的畸形可以带来手术难题,这在技术上要求很高,并可能严重影响治疗的结果。裂孔的总患病率为0.99 ~ 13.4%,裂孔的总患病率为0.23% ~ 16.9%。Elliott & Bowers[3]报道肺泡开裂和开孔分别与9.19%和10.93%相关。
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引用次数: 0
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