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Optimal Inventory Strategies for Pharmaceutical Products Incorporating Carbon Emissions 考虑碳排放的药品最优库存策略
Pub Date : 2019-05-28 DOI: 10.19080/ctbeb.2019.19.556008
P. S
Health sector is a significant source of carbon emissions around the world. Today healthcare industries are looking for solutions to reduce carbon emissions associated with their operations. Operational adjustments, such as modifications in inventory strategies, have proven to be an effective way to decrease emissions. This paper offers optimal inventory strategies for healthcare system to achieve target customer service level while minimizing system total cost and carbon emissions.
卫生部门是世界各地碳排放的一个重要来源。如今,医疗保健行业正在寻找解决方案,以减少与其运营相关的碳排放。操作调整,如修改库存策略,已被证明是减少排放的有效方法。本文为医疗保健系统提供了最优库存策略,以达到目标客户服务水平,同时最小化系统总成本和碳排放。
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引用次数: 0
Decrease Corneal Hysteresis in Early Glaucoma Patients Measured with Ocular Response Analyzer (Ora) Helps in Early Diagnosis of Glaucoma 眼反应分析仪(Ora)测定早期青光眼患者角膜迟滞的减少有助于青光眼的早期诊断
Pub Date : 2019-05-17 DOI: 10.19080/ctbeb.2019.19.556004
D. Szumny
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引用次数: 0
Profitabilities and Constraints to Sweet Potato Production in Nigeria 尼日利亚甘薯生产的利润和制约因素
Pub Date : 2019-05-15 DOI: 10.19080/ctbeb.2019.19.556007
Udemezue Jc
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引用次数: 7
Preserving Health and Achieving Longevity Through Caloric Restriction and Symbiotic Equilibrium with Gut Microbiome 通过热量限制和肠道微生物群的共生平衡来保持健康和长寿
Pub Date : 2019-05-09 DOI: 10.19080/ctbeb.2019.19.556003
Vinod Nikhra
The Health Preservation and Longevity The prolongation of life span achieved in recent decades is triumph of modern medicine. The lead challenge now is to promote healthy lifespan along with reducing incidence and severity of chronic and degenerative diseases, and the morbid frailty associated with later years. The host-microbiota interactions can be viewed in the broader context of genetic and epigenetic concepts. The lifestyle changes including dietary alterations accompanying aging have impact on gut microbiota and the activity of the innate immune system, intern, is influenced by gut microbiota. The gut microbiota also modulates cardiometabolic and inflammatory processes, thus influencing aging process. There is evidence that optimal CR along with adequate nutrition can reduce adiposity, chronic inflammation and insulin resistance, and promote health and quality of life along with satisfactory level of activity of daily living (ADL) in older adults. Further, as documented by recent research, the loss of gut microbiota diversity occurs during later years and modulates aging process adversely. The loss of core microbiota diversity with advancing age, has been associated with increased frailty and degenerative diseases along with cognitive decline. Diet-microbiota-health interactions and the lifestyle changes including dietary alterations accompanying aging have impact on gut microbiota. Since the gut microbiota modulates cardiometabolic and immunological processes, the microbiota alterations with aging mean that older adults may experience accelerated aging-related health loss. Further, the age-associated alterations in composition, diversity and functional aspects of gut microbiota have been related to age-associated decline in immune system functioning (immunosenescence) and low-grade chronic inflammation (inflam-aging), which accompany various aging-associated pathologies. The gut microbiota has crucial impact on aging process, and as documented by recent studies the microbiota-targeted interventions for normalization of gut microbiota may have health-span-promoting effects. The CR with adequate nutrition and microbiota-targeted dietary and probiotic, prebiotic and symbiotic interventions are likely to favourably modulate the host health and aging process by enhancement of antioxidant activity, suppression of chronic inflammation and improvement of immune homeostasis and cardiometabolic profile.
近几十年来,人类寿命的延长是现代医学的一大胜利。目前的主要挑战是促进健康寿命,同时降低慢性和退行性疾病的发病率和严重程度,以及与老年相关的病态虚弱。宿主-微生物群的相互作用可以在遗传和表观遗传概念的更广泛的背景下进行观察。随着年龄的增长,生活方式的改变,包括饮食的改变,会对肠道微生物群产生影响,而先天免疫系统的活性也会受到肠道微生物群的影响。肠道微生物群还调节心脏代谢和炎症过程,从而影响衰老过程。有证据表明,最佳的CR与充足的营养可以减少肥胖、慢性炎症和胰岛素抵抗,促进老年人的健康和生活质量,并达到令人满意的日常生活活动(ADL)水平。此外,最近的研究表明,肠道微生物群多样性的丧失发生在晚年,并对衰老过程产生不利影响。随着年龄的增长,核心微生物群多样性的丧失与虚弱和退行性疾病的增加以及认知能力下降有关。饮食-微生物群-健康的相互作用和生活方式的改变,包括随年龄增长的饮食改变,对肠道微生物群有影响。由于肠道微生物群调节心脏代谢和免疫过程,随着年龄的增长,微生物群的改变意味着老年人可能会加速衰老相关的健康损失。此外,肠道微生物群的组成、多样性和功能方面的年龄相关改变与免疫系统功能的年龄相关下降(免疫衰老)和伴随各种衰老相关病理的低级别慢性炎症(炎症老化)有关。肠道菌群对衰老过程具有至关重要的影响,最近的研究表明,针对肠道菌群的干预措施可能具有促进健康的作用。通过适当的营养和针对微生物群的饮食和益生菌、益生元和共生干预,CR可能通过增强抗氧化活性、抑制慢性炎症、改善免疫稳态和心脏代谢谱来调节宿主健康和衰老过程。
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引用次数: 0
Continuum-Level Simulations of Biopolymer Networks: A Minireview 生物聚合物网络的连续级模拟:综述
Pub Date : 2019-04-18 DOI: 10.19080/ctbeb.2019.19.556005
Yuan Lin
The mechanical properties of living cells are governed by the cytoskeleton, a network consisting of many different biopolymers together with transient linker proteins [1]. Biopolymers, especially those composed of globular proteins, are known to be semiflexible, that is the persistence length of these filaments is often comparable to their contour length, leading to small, yet significant, thermal fluctuations around a straight conformation and ultimately resulting in mechanical properties far from those exhibited by synthetic materials made of highly flexible polymers [2]. Theoretically, it remains a great challenge to understand/predict how a semiflexible filament network behave because of its many-body nature as well as the coupled elastic and entropic effects involved. For this reason, there has been a growing interest in the direct simulation on computer-generated networks in recent years. Here, we briefly review various continuum-level simulation approaches that have been developed in the past few decades.
活细胞的力学特性由细胞骨架控制,细胞骨架是由许多不同的生物聚合物和瞬时连接蛋白组成的网络[1]。生物聚合物,尤其是那些由球状蛋白质组成的生物聚合物,是半柔性的,也就是说,这些细丝的持续长度通常与其轮廓长度相当,导致沿直线构象的小而显著的热波动,最终导致的机械性能与由高度柔性聚合物制成的合成材料所表现出的力学性能相去甚远[2]。从理论上讲,理解/预测半柔性丝网络的行为仍然是一个巨大的挑战,因为它的多体性质以及所涉及的耦合弹性和熵效应。由于这个原因,近年来人们对计算机生成网络的直接模拟越来越感兴趣。在这里,我们简要回顾了过去几十年来发展起来的各种连续级模拟方法。
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引用次数: 0
Prevalence of Substance Abusers in a Tourist Area 旅游区药物滥用的流行程度
Pub Date : 2019-04-09 DOI: 10.19080/ctbeb.2019.19.556001
S. Kumar
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引用次数: 0
Is Laccase Enzyme an Answer for Sustainable Thatch Management in Turfgrass Systems: A Review 漆酶是草坪草系统可持续茅草管理的答案吗
Pub Date : 2019-04-09 DOI: 10.19080/ctbeb.2019.19.556002
S. Sidhu
Lignin, a major component of plant cell wall, acts as a protective matrix and limits microbial degradation of cellulose and hemi-celluloses which are readily degraded by microbes [1]. Heterogenous and complex structure of lignin macro-molecule which is due to random coupling of three monomers makes it resistant to microbial degradation and hence a rate limiting step in organic matter decomposition [2-5]. Formation of thatch layer in turfgrass systems is accelerated when organic matter accumulation rate exceeds its degradation rate. Excessive thatch layer accumulation leads to physical conditions in thatch which are detrimental to turfgrass [6]. Cultural management practices such as core aeration, vertical mowing, and grooming are destructive in nature and adversely impact turf quality.
木质素是植物细胞壁的主要成分,具有保护基质作用,限制微生物对容易被微生物降解的纤维素和半纤维素的降解。由于三种单体的随机偶联,木质素大分子具有多相和复杂的结构,使其具有抗微生物降解的能力,因此是有机物分解的限速步骤[2-5]。在草坪草系统中,当有机质积累速度超过其降解速度时,茅草层的形成速度加快。过度的茅草层堆积导致茅草内部的物理状况不利于草坪草生长。文化管理实践,如核心通风、垂直修剪和梳理,本质上是破坏性的,并对草坪质量产生不利影响。
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引用次数: 0
Pattern Occupational Health Problems of building Construction Workers 模式:建筑施工工人职业健康问题
Pub Date : 2019-04-09 DOI: 10.19080/ctbeb.2019.18.556000
S. Kumar
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引用次数: 0
Prevalence of Skin Diseases in a Slum Area 贫民窟地区皮肤病的流行情况
Pub Date : 2019-04-09 DOI: 10.19080/ctbeb.2019.18.555999
N. Kotwal, S. Kumar, M. Malhotra, Mohammad Sarwar Mir
Skin diseases are one of the most ubiquitous health problems, affecting 1 in 5 persons in the UK and 1 in 3 in the US, but there are large differences between countries, climates and cultures [1]. The highest prevalence has been reported from developing countries and poor areas. In the mountainous region of northern India, the overall prevalence is 45.3%5, while, in rural Sumatra, it is 28.2%. In Africa, reported prevalence (Figure 1) vary between 11.7% in Bamako, Mali, to 48% in rural Ethiopia. The published prevalence figures in children are also high, 32% in Kenya, 34% in Mali, 31.3% in Hong Kong and 38.8% in northern India.
皮肤病是最普遍存在的健康问题之一,在英国有五分之一的人受其影响,在美国有三分之一的人受其影响,但不同国家、气候和文化之间存在很大差异[1]。据报告,发展中国家和贫困地区的患病率最高。在印度北部山区,总患病率为45.3%5,而在苏门答腊岛农村,患病率为28.2%。在非洲,报告的患病率(图1)从马里巴马科的11.7%到埃塞俄比亚农村的48%不等。公布的儿童患病率也很高,肯尼亚为32%,马里为34%,香港为31.3%,印度北部为38.8%。
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引用次数: 0
Fermentative Kinetic Modeling for Protein Biomass from Sugar Diversification 糖多样化产生的蛋白质生物质发酵动力学模型
Pub Date : 2019-03-26 DOI: 10.19080/ctbeb.2019.18.555998
O. Pérez, J. E. Miño, Agustín García, E. González
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引用次数: 1
期刊
Current Trends in Biomedical Engineering & Biosciences
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