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In-vivo Evaluation of Anti-Coccidial Efficacy of Aqueous Extract of Allium sativum and Carica papaya in Experimentally Infected Broiler Chicks 大蒜和木瓜水提物在实验感染肉鸡体内抗球虫效果的研究
Pub Date : 2018-09-10 DOI: 10.19080/CTBEB.2018.16.555946
Udo Ej
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引用次数: 1
Effective Clinical Project Management to Streamline Clinical Trial 有效的临床项目管理,简化临床试验
Pub Date : 2018-09-06 DOI: 10.19080/ctbeb.2018.16.555937
M. Patel
There is serious amount of time and efforts involved in clinical research industry supporting the drug development process with the project management tool. The question arise is, is clinical trial project? Clinical trial has defined beginning and end, no matter whether it will continue for several months to 10-15 years. The finance and human resources for conducting those trials are finite It is quite healthy to handle clinical trial as a project which makes management well defined and structured. The deliverable of every clinical trials is unique, but it can be defined as result. clinical trial is always characterized by its progressive elaboration and a well-prepared clinical trial protocol (CTP) is an example of a step of development. Managing clinical trial required efficient trial management, whatever the size and complexity it is. For the past three decades, industry has invented and reinvented the trial management wheel. To improve the successful and timely delivery, it is time to produce standard trial management guidelines.
临床研究行业使用项目管理工具支持药物开发过程需要大量的时间和精力。问题是,临床试验是项目吗?临床试验已经定义了开始和结束,不管它是否会持续几个月到10-15年。进行临床试验的财力和人力资源都是有限的。将临床试验作为一个项目来处理是非常健康的,这样可以使管理得到良好的定义和结构。每个临床试验的交付成果都是独一无二的,但它可以被定义为结果。临床试验的特点是逐步细化,精心准备的临床试验方案(CTP)就是一个逐步发展的例子。管理临床试验需要有效的试验管理,无论其规模和复杂性如何。在过去的三十年里,工业界发明并重新发明了审判管理轮。为了提高成功和及时的交付,是时候制定标准的试验管理指南了。
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引用次数: 2
Allergen Preparation and Standardization: An Update 过敏原制备和标准化:最新进展
Pub Date : 2018-09-06 DOI: 10.19080/ctbeb.2018.16.555938
Singh Ab
Allergy is defined as an exaggerated response of the adaptive immune system typified by immunoglobulin E (IgE) responses against the offending substance called ‘allergen’ [1]. The immunologic basis of allergic diseases is observed in two phases: sensitization and development of memory T and B cell responses along with IgE production [2]. Allergy manifests in form of various conditions such as anaphylaxis, urticaria, angioedema, allergic rhinoconjunctivitis, allergic asthma, serum sickness, allergic vasculitis, hypersensitivity pneumonitis, atopic dermatitis (eczema), contact dermatitis and granulomatous reactions, as well as the colorful spectrum of food or drug induced hypersensitivity reactions [2]. Asthma, allergic rhinitis, atopic dermatitis and inhalant sensitization have been appropriately referred to as first wave of the epidemic of the 21st century [3,4]. During the last 60 years, there has been a rise in the epidemic prevalence of allergic disorders, which is expected to reach up to 4 billion in 2050s [5]. Allergic reactions are initiated by certain types of antigens, referred to as allergens, which have been broadly categorized into four classes as Inhalant (pollen,fungi,dust), Ingestants (food, drugs), Contactants (latex, plant trichomes) and Injectants (drugs). Allergen immunotherapy (AIT) has been used to treat allergic disease since the early 1900s [6]. Allergen-specific immunotherapy (also known as allergy shots) identified as disease-modifying intervention for allergic disease involves subcutaneous administration of gradually increasing quantities of the patient’s relevant allergens until a dose is reached that is effective in inducing immunologic tolerance to the allergens [7]. The term “allergen extracts” refers to solutions of proteins or glycoproteins extracted from source material not yet incorporated into a therapeutic allergen immunotherapy extract [8]. Vials of allergen immunotherapy extracts are prepared individually (specifically customized) using saline buffers for each patient to reduce the risk of allergen cross-contamination, anaphylactic side effects, sensitization to unknown allergens in extract. Major allergens responsible for allergy in extract can be modified chemically or enzymatically to reduce their allergenic potential while still retaining the immunogenicity for achieving same tolerance as natural counterpart. The collection of raw materials for allergen preparation should be performed by qualified personnel and appropriate, measures should be taken to ensure correct characterization and quality check of source materials. For allergen immunotherapy trained Compounding personnel including, but not limited to, registered nurses, medical assistants, or physicians’ assistants, be employed which strictly follow allergen extract preparation guidelines. Allergen immunotherapy efficacy and precision of diagnostic allergy skin testing are entirely dependent on the quality of the allergen extracts used [8]. Standardi
过敏被定义为适应性免疫系统的一种过度反应,以免疫球蛋白E (IgE)对被称为“过敏原”[1]的有害物质的反应为典型。过敏性疾病的免疫学基础分为两个阶段:致敏和记忆T细胞和B细胞反应的发展以及IgE的产生。过敏表现为各种情况,如过敏反应、荨麻疹、血管性水肿、过敏性鼻结膜炎、过敏性哮喘、血清病、过敏性血管炎、过敏性肺炎、特应性皮炎(湿疹)、接触性皮炎和肉芽肿反应,以及食物或药物引起的各种过敏反应[2]。哮喘、变应性鼻炎、特应性皮炎和吸入性致敏被恰当地称为21世纪的第一波流行病[3,4]。在过去60年中,过敏性疾病的流行率有所上升,预计到2050年将达到40亿人。过敏反应是由某些类型的抗原引起的,这些抗原被称为过敏原,大致分为四类:吸入物(花粉、真菌、灰尘)、食入物(食物、药物)、接触物(乳胶、植物毛状体)和注射物(药物)。自20世纪初以来,过敏原免疫疗法(AIT)已被用于治疗过敏性疾病。过敏原特异性免疫疗法(也称为过敏注射)被确定为过敏性疾病的疾病改善干预,包括皮下给药逐渐增加患者相关过敏原的量,直到达到有效诱导对过敏原免疫耐受的剂量。术语“过敏原提取物”是指从尚未纳入治疗性过敏原免疫治疗提取物[8]的源材料中提取的蛋白质或糖蛋白的溶液。每个患者使用生理盐水缓冲液单独制备小瓶过敏原免疫治疗提取物(特别定制),以降低过敏原交叉污染、过敏副作用、对提取物中未知过敏原致敏的风险。提取物中引起过敏的主要过敏原可以通过化学或酶修饰来降低其致敏潜力,同时保持免疫原性,以达到与天然对应物相同的耐受性。过敏原制备原料的收集应由有资质的人员进行,并应采取适当的措施确保原料的正确表征和质量检查。对于过敏原免疫治疗训练的配制人员,包括但不限于,应雇用严格遵循过敏原提取物制备指南的注册护士、医疗助理或医师助理。过敏原免疫治疗的疗效和诊断性过敏皮肤试验的准确性完全取决于所使用的过敏原提取物的质量。如立场文件[8-10]所示,标准化过敏原制剂已被推荐用于免疫治疗和诊断试剂盒。标准化提取物的优点是生物活性更一致,因此由提取物效力变化引起的不良反应的风险应该降低。
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引用次数: 4
Reminders for Clinical Application of Extra Acupoints 额外穴位临床应用的注意事项
Pub Date : 2018-09-06 DOI: 10.19080/CTBEB.2018.16.555939
T. Hong
Pattern identification is the key concept of the traditional Chinese Medicine theories, which unfortunately cannot apply to extra acupoints for the lack of Yin and Yang. However, the recent studies on extra acupoints selected in combination with traditional acupoints on the traditional fourteen meridians are marking the beginning of a new chapter.
模式识别是中医理论的核心概念,但不幸的是,它不适用于阴阳不足的额外穴位。然而,最近对传统十四经络上的传统穴位结合的额外取穴的研究,正标志着一个新的篇章的开始。
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引用次数: 3
Effects of Taro Varieties and Blending Ratios on Proximate Compositions and Anti-Nutritional Factors of Taro (Colocasia esculenta) –Wheat (Aestium triticium) Composite Bread 芋品种及配比对芋-小麦复合面包近似成分及抗营养因子的影响
Pub Date : 2018-08-31 DOI: 10.19080/ctbeb.2018.16.555935
Lamrot W Mariam
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引用次数: 1
Biomedical Response and Different Applications of Magnetic Nanomaterials 磁性纳米材料的生物医学响应及其不同应用
Pub Date : 2018-08-30 DOI: 10.19080/CTBEB.2018.16.555934
Bhunia Ak
From the ultimate decade, nanoscience and nanotechnology have been multiple explored for wide studies in medical science. The bodily principles vital a few contemporary biomedical programs of magnetic nanoparticles (MNPs) are inspected. Starting from basic magnetic concepts of MNPs which are responsible for biomedicine, and drawing on examples from biomedicine, the relevant physics of MNPs and their responses to implemented magnetic fields are inspected. This mini review discusses about the different responsible properties for biomedicine and the various biomedical applications of MNPs as reported by the different researchers.
从上个十年开始,纳米科学和纳米技术在医学科学中得到了广泛的研究。考察了磁性纳米颗粒(MNPs)在当代生物医学研究中的物理原理。从负责生物医学的MNPs的基本磁概念出发,结合生物医学实例,考察了MNPs的相关物理特性及其对实现磁场的响应。这篇小型综述讨论了不同研究人员报道的MNPs的不同生物医学特性和各种生物医学应用。
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引用次数: 0
Phytochemical Constituents, Antibacterial and Antioxidant Activities of some Medicinal Plants 一些药用植物的植物化学成分、抗菌和抗氧化活性
Pub Date : 2018-08-29 DOI: 10.19080/ctbeb.2018.16.555933
Heshmat S Aldesuquy
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引用次数: 1
On Health Influences of Cell Phones 手机对健康的影响
Pub Date : 2018-08-27 DOI: 10.19080/ctbeb.2018.16.555932
S. Berkovich
The question whether cell phones can have adverse health effects continues to produce a lot of controversies. From time to time there appear sporadic reports of various types of medical harms alleged to cell phones. Those include headaches, tiredness, and particularly cancers. The abundance of the experiments does not clarify this issue. Overall, tumors are likely to be related to the cell phones radiation. But findings are not definitive. Thus, the most recent report [1], categorically rejects that cell phones in any way affect human health: “If tumors were on the rise as the result of increased phone radiation, we would know it by now”
手机是否会对健康产生不良影响的问题继续引起许多争议。不时出现一些零星的报告,称手机造成了各种各样的医疗危害。包括头痛、疲劳,尤其是癌症。大量的实验并没有澄清这个问题。总的来说,肿瘤很可能与手机辐射有关。但研究结果并不是决定性的。因此,最新的报告[1]断然否认手机以任何方式影响人类健康:“如果肿瘤的增加是由于手机辐射增加的结果,我们现在早就知道了。”
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引用次数: 0
Old Age Health Problems among Family Members in Rural Community 农村社区家庭成员的老年健康问题
Pub Date : 2018-08-27 DOI: 10.19080/ctbeb.2018.16.555931
Susheelkumar V Ronad
Susheelkumar V Ronad1*, Chetan S Patali2, Shridhar H Gondbal3, Kirankumar TC4, Pankaja TC5, Rajendra Badesgol6, Veeresh Nandgaon7 and Timmapur RM8 1Department of Psychiatric Nursing Dimhans Dharwad, India 2Dhanush institute of Nursing Sciences Bagaklot, India 3Staff Nurse, Indira Gandhi Children’s Hospital, India 4Department of Management Studies, Karnataka Arts College, India 5RL Law College, India 6Department of Police, India 7KLE Institute of Nursing Sciences Belgaum, India 8Psychiatric social worker, Dimhans Dharwad, India
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引用次数: 0
Psychosocial Impact of Acne: A Community Based Cross Sectional Study 痤疮的社会心理影响:基于社区的横断面研究
Pub Date : 2018-07-10 DOI: 10.19080/ctbeb.2018.16.555936
Mubashar Mashqoor Mir
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引用次数: 0
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Current Trends in Biomedical Engineering & Biosciences
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