Pub Date : 2023-08-09DOI: 10.2174/2215083810666230809103444
Raghav Mishra, P. Dhakad, Isha Mishra, Vikram Sharma
In traditional medicine, Safed musli is a very popular herb. Natural sex tonics like Chlorophytum borivilianum (C. borivilianum) are effective in alleviating sexual disorders. Local healers in indigenous communities of India mostly use it for ethnic medicine. The circulation of blood is one of the functions it improves to enhance strength and energy. Since ancient times, the tuber roots of the plant Safed musli have been used to treat weakness and male impotency. The aim of this work is to bridge the scientific evidence with the pharmacological, phytochemical, and folkloric claims reported in different sources belonging to C. borivilianum. To build the manuscript, a detailed literature review was carried out by thoroughly analyzing globally accepted scientific research databases. Safed musli is widely recognized for its efficacy in addressing male impotence. The abundant presence of phytoconstituents, particularly saponins, contributes to the nutritional and multifaceted therapeutic significance of C. borivilianum. The current review enlightens the pharmacotherapeutic potential of C. borivilianum, comprising its origin and distribution, botany, proximate composition, method of enhancing seed germination, pathology, phytochemistry, pharmacology, and traditional uses. The scope for future research is provided by the present review, which also furnishes a gateway for filling the existing gap in its various aspects of investigation.
{"title":"A Concise Review on Therapeutic Potential, Phytochemistry and Traditional Applications of Safed Musli (Chlorophytum borivilianum)","authors":"Raghav Mishra, P. Dhakad, Isha Mishra, Vikram Sharma","doi":"10.2174/2215083810666230809103444","DOIUrl":"https://doi.org/10.2174/2215083810666230809103444","url":null,"abstract":"\u0000\u0000In traditional medicine, Safed musli is a very popular herb. Natural sex tonics like Chlorophytum borivilianum (C. borivilianum) are effective in alleviating sexual disorders. Local healers in indigenous communities of India mostly use it for ethnic medicine. The circulation of blood is one of the functions it improves to enhance strength and energy. Since ancient times, the tuber roots of the plant Safed musli have been used to treat weakness and male impotency.\u0000\u0000\u0000\u0000The aim of this work is to bridge the scientific evidence with the pharmacological, phytochemical, and folkloric claims reported in different sources belonging to C. borivilianum.\u0000\u0000\u0000\u0000To build the manuscript, a detailed literature review was carried out by thoroughly analyzing globally accepted scientific research databases.\u0000\u0000\u0000\u0000Safed musli is widely recognized for its efficacy in addressing male impotence. The abundant presence of phytoconstituents, particularly saponins, contributes to the nutritional and multifaceted therapeutic significance of C. borivilianum.\u0000\u0000\u0000\u0000The current review enlightens the pharmacotherapeutic potential of C. borivilianum, comprising its origin and distribution, botany, proximate composition, method of enhancing seed germination, pathology, phytochemistry, pharmacology, and traditional uses. The scope for future research is provided by the present review, which also furnishes a gateway for filling the existing gap in its various aspects of investigation.\u0000","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42095122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-07DOI: 10.2174/2215083810666230807155214
Yangchen Dolma Kom, R. Karthiyayini
Nature’s never-ending gift, which counts as one of the most valuable medicines in the entire world, the Ophiocordyceps sinensis, also known as caterpillar fungus, is a traditional Chinese medicine found in Tibetan plateaus. During the season of spring, many shepherd search for this caterpillar fungus as its value in the market is very high. Moreover, due to the effects of climatic change on its population and increasing demand, O. sinensis is now an endangered species. It can treat almost many diseases, such as cardiovascular disease, respiratory diseases, immune dysfunction etc. The chemical composition of this fungus includes amino acids, glutamic acid, polyamines, cordycepic acid, saccharides, sterols, nucleotides, sugar derivatives, fatty acids, vitamins, and oleic acid.
{"title":"A REVIEW: Ophiocordycep Sinensis (Berk.) as a Traditional Tibetan\u0000Medicine and its Potential in the Treatment of Various Human Ailments","authors":"Yangchen Dolma Kom, R. Karthiyayini","doi":"10.2174/2215083810666230807155214","DOIUrl":"https://doi.org/10.2174/2215083810666230807155214","url":null,"abstract":"\u0000\u0000Nature’s never-ending gift, which counts as one of the most valuable medicines in the\u0000entire world, the Ophiocordyceps sinensis, also known as caterpillar fungus, is a traditional Chinese\u0000medicine found in Tibetan plateaus. During the season of spring, many shepherd search for this caterpillar fungus as its value in the market is very high. Moreover, due to the effects of climatic\u0000change on its population and increasing demand, O. sinensis is now an endangered species. It can\u0000treat almost many diseases, such as cardiovascular disease, respiratory diseases, immune dysfunction etc. The chemical composition of this fungus includes amino acids, glutamic acid, polyamines,\u0000cordycepic acid, saccharides, sterols, nucleotides, sugar derivatives, fatty acids, vitamins, and oleic\u0000acid.\u0000","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45585348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-04DOI: 10.2174/2215083810666230804095036
Keshav Bansal, Vanshita, M. Bajpai
Bacoside A is a triterpenoid saponin and nootropic herb that can be extracted from Bacopa monnieri Linn., Scrophulariaceae. It is a glabrous and succulent herb used traditionally for centuries in treating various illnesses, mainly as a cardiotonic and nerve tonic, and has been considered an eminent Ayurvedic medicine. Various studies reported that the herb consists of a wide range of potentially bioactive, phytochemical constituents with synergistic effects. Bacoside A is a major constituent of B. monnieri, with diverse biological functions and significant therapeutic potential, as given by various researchers and preclinical studies. It possesses various biological activities such as hepatoprotective, anti-osteoporotic, anti-ulcerogenic, anti-inflammatory, anti-tumor, wound healing, and neuroprotective effects. This review compiled the preclinical evidence-based studies and present knowledge of bacoside A's potential benefits and fruitful impact on human health, and we provided a comprehensive perspective of bacoside A in various disease treatments.
{"title":"Bacoside A: A Promising Medication for Treatment of Various Disorders","authors":"Keshav Bansal, Vanshita, M. Bajpai","doi":"10.2174/2215083810666230804095036","DOIUrl":"https://doi.org/10.2174/2215083810666230804095036","url":null,"abstract":"\u0000\u0000Bacoside A is a triterpenoid saponin and nootropic herb that can be extracted from Bacopa monnieri Linn., Scrophulariaceae. It is a glabrous and succulent herb used traditionally for centuries in treating various illnesses, mainly as a cardiotonic and nerve tonic, and has been considered an eminent Ayurvedic medicine. Various studies reported that the herb consists of a wide range of potentially bioactive, phytochemical constituents with synergistic effects. Bacoside A is a major constituent of B. monnieri, with diverse biological functions and significant therapeutic potential, as given by various researchers and preclinical studies. It possesses various biological activities such as hepatoprotective, anti-osteoporotic, anti-ulcerogenic, anti-inflammatory, anti-tumor, wound healing, and neuroprotective effects. This review compiled the preclinical evidence-based studies and present knowledge of bacoside A's potential benefits and fruitful impact on human health, and we provided a comprehensive perspective of bacoside A in various disease treatments.\u0000","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45255115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-03DOI: 10.2174/2215083810666230803101424
N. T. Nistane, Mayur B. Kale, R. Das, Mohit Umare, M. Umekar, A. Hemke, Vishal R. Gajbhiye
Pandemics are large-scale epidemics of infectious illness that may cause major economical, cultural, and political upheaval while also increasing illness and mortality across a huge geographic area. Evidence shows that pandemics have increased during the last century as a result of increasing international travel and connectivity, industrialization, agricultural expansion, and higher destruction of the natural environment. Over time, emerging pathogen strains cause pandemics that raise suffering, death, and instability in countries. Flu, plague, cholera, HIV, and the current COVID-19 pandemic caused by a novel coronavirus are just a few of the pathogen outbreaks. Unfortunately, given the lack of information and instruments to tackle the problem, managing new and developing infections is frequently challenging. Yet, the use of herbal remedies to treat new and developing infectious illnesses has received much interest. Until the invention of antibiotics, herbal plants, their preparations, and extracted phytoconstituents were reported to be efficient in reducing infectious diseases. Plants contain numerous complex metabolites, such as amino acids, alkaloids, tannins, flavonoids, terpenoids, and glycosides, that show different therapeutic activities. This review provides vital and useful information regarding herbal drugs and their effectiveness against various pathogens that cause major pandemics.
{"title":"Herbal Remedies: An Emerging Alternative for the Treatment of Pandemic Diseases","authors":"N. T. Nistane, Mayur B. Kale, R. Das, Mohit Umare, M. Umekar, A. Hemke, Vishal R. Gajbhiye","doi":"10.2174/2215083810666230803101424","DOIUrl":"https://doi.org/10.2174/2215083810666230803101424","url":null,"abstract":"\u0000\u0000Pandemics are large-scale epidemics of infectious illness that may cause major economical, cultural, and political upheaval while also increasing illness and mortality across a huge geographic area. Evidence shows that pandemics have increased during the last century as a result of increasing international travel and connectivity, industrialization, agricultural expansion, and higher destruction of the natural environment. Over time, emerging pathogen strains cause pandemics that raise suffering, death, and instability in countries. Flu, plague, cholera, HIV, and the current COVID-19 pandemic caused by a novel coronavirus are just a few of the pathogen outbreaks. Unfortunately, given the lack of information and instruments to tackle the problem, managing new and developing infections is frequently challenging. Yet, the use of herbal remedies to treat new and developing infectious illnesses has received much interest. Until the invention of antibiotics, herbal plants, their preparations, and extracted phytoconstituents were reported to be efficient in reducing infectious diseases. Plants contain numerous complex metabolites, such as amino acids, alkaloids, tannins, flavonoids, terpenoids, and glycosides, that show different therapeutic activities. This review provides vital and useful information regarding herbal drugs and their effectiveness against various pathogens that cause major pandemics.\u0000","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41991155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-03DOI: 10.2174/2215083810666230803093156
Niraj Kumar Singh, Ashutosh Solanki
Hepatic encephalopathy (HE) is a serious neuropsychiatric disorder caused in patients with both; acute and chronic liver diseases, which consists of various complications ranging from cognitive impairment, disorientation, confusion, and coma. The available therapies mainly focus on decreasing ammonia levels either through increasing its elimination or decreasing its production, some medications may subside the duration and limit the consequences of HE, but there is no complete available treatment for HE-like manifestation. Thus, there is a need to explore new pharmacotherapy for the treatment and management of HE. Flavonoids are polyphenolic compounds easily found in vegetables, fruits, flowers, beverages, and plants based foods. In modern research, flavonoids have gained attention due to their broad pharmacological properties, like anti-oxidant, anti-viral, anti-inflammatory, cardioprotective, cytoprotective, and neuroprotective activity. Several pre-clinical studies suggest that various flavonoids have a potential therapeutic role in a variety of metabolic-related neurological disorders, including HE. This review focuses on all pre-clinical reports that highlight the neuroprotective potential of natural flavonoids for the management of HE. Based on numerous pre-clinical studies and taking into account the therapeutic effects of natural flavonoids, the present study illustrates the cellular and molecular mechanisms responsible for the potential role of natural flavonoids as pharmacotherapy for the management and treatment of HE.
{"title":"Natural Flavonoids as an Intervention for Hepatic Encephalopathy: Pre-clinical Evidence-based Review","authors":"Niraj Kumar Singh, Ashutosh Solanki","doi":"10.2174/2215083810666230803093156","DOIUrl":"https://doi.org/10.2174/2215083810666230803093156","url":null,"abstract":"\u0000\u0000Hepatic encephalopathy (HE) is a serious neuropsychiatric disorder caused in patients with both; acute and chronic liver diseases, which consists of various complications ranging from cognitive impairment, disorientation, confusion, and coma. The available therapies mainly focus on decreasing ammonia levels either through increasing its elimination or decreasing its production, some medications may subside the duration and limit the consequences of HE, but there is no complete available treatment for HE-like manifestation. Thus, there is a need to explore new pharmacotherapy for the treatment and management of HE. Flavonoids are polyphenolic compounds easily found in vegetables, fruits, flowers, beverages, and plants based foods. In modern research, flavonoids have gained attention due to their broad pharmacological properties, like anti-oxidant, anti-viral, anti-inflammatory, cardioprotective, cytoprotective, and neuroprotective activity. Several pre-clinical studies suggest that various flavonoids have a potential therapeutic role in a variety of metabolic-related neurological disorders, including HE. This review focuses on all pre-clinical reports that highlight the neuroprotective potential of natural flavonoids for the management of HE. Based on numerous pre-clinical studies and taking into account the therapeutic effects of natural flavonoids, the present study illustrates the cellular and molecular mechanisms responsible for the potential role of natural flavonoids as pharmacotherapy for the management and treatment of HE.\u0000","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":"150 ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41275063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-01DOI: 10.2174/2215083810666230801122931
N. Ebrahimi, Ebrahim Fallahzadeh Abarghooee, A. Vazin, R. Ansari, M. Zarshenas
Gastroesophageal reflux disease (GERD) leads to increased contact of the acidic refluxate with the esophageal mucosa. Nearly 10- 20 % of the world's population is affected by GERD. Due to the complications associated with GERD, as well as complications of long-term treatment with current medications, and global demand toward Complementary and Alternative Medicine (CAM), this study evaluated the efficacy of a poly-herbal formulation known as Mastic pill (Habb-e-Mastaki) from traditional Persian medicine (TPM), previously reformulated and standardized, in a double-blinded randomized clinical trial. 34 patients in the drug group received 4 capsules of Mastic pill plus Omeprazole capsule 20 mg daily. 34 patients in the placebo group received the same dosing of Omeprazole and placebo. The medication was given to patients for a total duration of 4 weeks. All patients were requested to fill out the modified GERD-HRQL questionnaire at the beginning and every two weeks for a total duration of six weeks. Reflux, and heartburn severity score as well as disruption of personal life score significantly reduced in both groups, but it was more remarkable in the drug group (P-value = 0.0001). Dysphagia, early satiation, and nausea significantly reduced in the drug group while the placebo group showed no improvement. Our results suggest that constipation, bloating, belching, and odynophagia did not significantly improve in none of the groups. This study showed that Habb-e-Mastaki is effective against GERD. Further detailed in vitro and in vivo studies aimed at discovering the mechanism of action of this formulation and clinical studies involving a larger population will be necessary to explain and confirm the results obtained in the present study.
{"title":"The effectiveness of a poly-herbal formulation from traditional Persian medicine (TPM) in gastroesophageal reflux disease (GERD), a double-blinded randomized clinical trial","authors":"N. Ebrahimi, Ebrahim Fallahzadeh Abarghooee, A. Vazin, R. Ansari, M. Zarshenas","doi":"10.2174/2215083810666230801122931","DOIUrl":"https://doi.org/10.2174/2215083810666230801122931","url":null,"abstract":"\u0000\u0000Gastroesophageal reflux disease (GERD) leads to increased contact of the acidic refluxate with the esophageal mucosa. Nearly 10- 20 % of the world's population is affected by GERD. Due to the complications associated with GERD, as well as complications of long-term treatment with current medications, and global demand toward Complementary and Alternative Medicine (CAM), this study evaluated the efficacy of a poly-herbal formulation known as Mastic pill (Habb-e-Mastaki) from traditional Persian medicine (TPM), previously reformulated and standardized, in a double-blinded randomized clinical trial.\u0000\u0000\u0000\u000034 patients in the drug group received 4 capsules of Mastic pill plus Omeprazole capsule 20 mg daily. 34 patients in the placebo group received the same dosing of Omeprazole and placebo. The medication was given to patients for a total duration of 4 weeks. All patients were requested to fill out the modified GERD-HRQL questionnaire at the beginning and every two weeks for a total duration of six weeks.\u0000\u0000\u0000\u0000Reflux, and heartburn severity score as well as disruption of personal life score significantly reduced in both groups, but it was more remarkable in the drug group (P-value = 0.0001). Dysphagia, early satiation, and nausea significantly reduced in the drug group while the placebo group showed no improvement. Our results suggest that constipation, bloating, belching, and odynophagia did not significantly improve in none of the groups.\u0000\u0000\u0000\u0000This study showed that Habb-e-Mastaki is effective against GERD. Further detailed in vitro and in vivo studies aimed at discovering the mechanism of action of this formulation and clinical studies involving a larger population will be necessary to explain and confirm the results obtained in the present study.\u0000","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44272052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-01DOI: 10.2174/2215083808666220422094621
Yogesh Murti, Bhupesh Chander Semwal, Sonia Singh
Background: Marine ecosystem is one of the main natural sources of numerous biologically active components along with rich biodiversity. Marine biomaterials obtained from fungi, algae, bacteria, and fish, are considered promising candidates for providing various biological as well as biomedical application(s). Objective: The main focused objective of this manuscript is to take out the recent trends utilized in several marine-based biomaterials developed for pharmaceutical applications. Method: The literature contains valuable and collective information on the different bioactivities of marine-based biomaterials. A total of 287 articles are cited in the present review covering a broad spectrum of marine biomaterials, and their pharmaceutical importance. Information of different marine biomaterials along with their source, chemical nature, and pharmaceutical importance are exhaustively compiled here. Results: Marine-based biomaterials possess a wide range of physiochemical activities and modifications in these properties can also enhance the therapeutic and regenerative capacity. Marine biomaterials have proven a good source for the development of different areas of the pharmaceutical field and still, the application of marine biomaterials is going through revitalization in the biomedical field. Conclusion: Due to the amazing diversity involved in marine life, there would be more significant and remarked discoveries developed in the field of marine biomaterials in respect of future implementation in the pharmaceutical arena.
{"title":"Marine Biomaterials for Pharmaceutical Applications: A Review","authors":"Yogesh Murti, Bhupesh Chander Semwal, Sonia Singh","doi":"10.2174/2215083808666220422094621","DOIUrl":"https://doi.org/10.2174/2215083808666220422094621","url":null,"abstract":"Background: Marine ecosystem is one of the main natural sources of numerous biologically active components along with rich biodiversity. Marine biomaterials obtained from fungi, algae, bacteria, and fish, are considered promising candidates for providing various biological as well as biomedical application(s). Objective: The main focused objective of this manuscript is to take out the recent trends utilized in several marine-based biomaterials developed for pharmaceutical applications. Method: The literature contains valuable and collective information on the different bioactivities of marine-based biomaterials. A total of 287 articles are cited in the present review covering a broad spectrum of marine biomaterials, and their pharmaceutical importance. Information of different marine biomaterials along with their source, chemical nature, and pharmaceutical importance are exhaustively compiled here. Results: Marine-based biomaterials possess a wide range of physiochemical activities and modifications in these properties can also enhance the therapeutic and regenerative capacity. Marine biomaterials have proven a good source for the development of different areas of the pharmaceutical field and still, the application of marine biomaterials is going through revitalization in the biomedical field. Conclusion: Due to the amazing diversity involved in marine life, there would be more significant and remarked discoveries developed in the field of marine biomaterials in respect of future implementation in the pharmaceutical arena.","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134951517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-27DOI: 10.2174/2215083810666230727094905
Deepali Bansode, Tanvi Goel
Leishmaniasis is one of the most devastating and fatal diseases in humans that has been known to mankind and is caused by the parasite Leishmania. It is destructive since no vaccination is available and existing medicines are proving ineffective because of resistance development. A need for the discovery of newer drugs has emerged. The use of natural products for the prevention, diagnosis, and cure of diseases has rapidly increased. Following the trend, research in the field of natural products for treating leishmaniasis has also picked up. In the present review, the focus is on terpenes as anti-leishmanial agents. Terpenes are the least studied natural products for the treatment of the disease. The other part of the review covers the use of chitosan as an anti-leishmanial agent and other formulations of chitosan as a carrier in nano-formulations. From the survey, it was found that the essential oils containing terpenes are very effective. Moreover, the chitosan-based nanocarriers showed potent anti-leishmanial activity. The combined use of natural products and newer technologies for the delivery of drugs can eradicate various diseases.
{"title":"A review on anti-leishmanial activity of terpenes and chitosan as a carrier for nano-formulations","authors":"Deepali Bansode, Tanvi Goel","doi":"10.2174/2215083810666230727094905","DOIUrl":"https://doi.org/10.2174/2215083810666230727094905","url":null,"abstract":"\u0000\u0000Leishmaniasis is one of the most devastating and fatal diseases in humans that has been known to mankind and is caused by the parasite Leishmania. It is destructive since no vaccination is available and existing medicines are proving ineffective because of resistance development. \u0000A need for the discovery of newer drugs has emerged. The use of natural products for the prevention, diagnosis, and cure of diseases has rapidly increased. Following the trend, research in the field of natural products for treating leishmaniasis has also picked up. In the present review, the focus is on terpenes as anti-leishmanial agents. Terpenes are the least studied natural products for the treatment of the disease. The other part of the review covers the use of chitosan as an anti-leishmanial agent and other formulations of chitosan as a carrier in nano-formulations. \u0000From the survey, it was found that the essential oils containing terpenes are very effective. Moreover, the chitosan-based nanocarriers showed potent anti-leishmanial activity. The combined use of natural products and newer technologies for the delivery of drugs can eradicate various diseases.\u0000","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48416353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-12DOI: 10.2174/2215083810666230712091733
Anuradha Verma, Anshika Garg, Sultan Ahmad, Saquib Haider, B. Kumar, Ritu Chauhan, Manish K. Singh, SambhuCharan Mondal
Hypertension, either high blood pressure or pulmonary hypertension, both affect the life of patients in many ways. Does Pulmonary hypertension similar to high blood pressure? Does it affect old age people or the neonatal age groups also? What were the reasons for pulmonary hypertension? Does pulmonary hypertension manageable with modern and traditional drugs? The purpose of the literature review is to identify the targeted therapy for pulmonary hypertension and also include the plants that may be effective for the management of pulmonary hypertension. The author has reviewed many targeted drugs that are presently used, and many are in research that was found effective in making the life of patients as normal as possible. They also reviewed about 15 herbal plants which were found effective in the management of the disease. As pulmonary hypertension is not treatable, it can only be managed by changing lifestyle and food habits; therefore, the authors emphasized reviewing the traditional approach for the management of pulmonary hypertension.
{"title":"A Review of Modern and Traditional Approaches for the Management of Pulmonary Hypertension","authors":"Anuradha Verma, Anshika Garg, Sultan Ahmad, Saquib Haider, B. Kumar, Ritu Chauhan, Manish K. Singh, SambhuCharan Mondal","doi":"10.2174/2215083810666230712091733","DOIUrl":"https://doi.org/10.2174/2215083810666230712091733","url":null,"abstract":"\u0000\u0000Hypertension, either high blood pressure or pulmonary hypertension, both affect the life of patients in many ways.\u0000\u0000\u0000\u0000Does Pulmonary hypertension similar to high blood pressure?\u0000Does it affect old age people or the neonatal age groups also?\u0000What were the reasons for pulmonary hypertension?\u0000Does pulmonary hypertension manageable with modern and traditional drugs?\u0000\u0000\u0000\u0000The purpose of the literature review is to identify the targeted therapy for pulmonary hypertension and also include the plants that may be effective for the management of pulmonary hypertension.\u0000\u0000\u0000\u0000The author has reviewed many targeted drugs that are presently used, and many are in research that was found effective in making the life of patients as normal as possible.\u0000They also reviewed about 15 herbal plants which were found effective in the management of the disease. \u0000As pulmonary hypertension is not treatable, it can only be managed by changing lifestyle and food habits; therefore, the authors emphasized reviewing the traditional approach for the management of pulmonary hypertension.\u0000","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42261260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-10DOI: 10.2174/2215083810666230710122114
N. Rani, Randhir Dahiya, Praveen Kumar, Nandini Verma
Since ancient times, medicinal plants have been in use in medicine and daily life. To develop new antifungal compounds with low toxicity and high efficacy followed by high bioavailability, the constituents of Terminalia chebula were studied. The chemical constituents of the plant were evaluated for antifungal potential via Molergo Virtual Docker against the enzyme 14α-demethylase. The study depicted that tannins exhibited very good potential against the enzyme and could be used further for lead development. The study revealed that the plant possessed various constituents with potential antifungal properties and low toxicity.
{"title":"In silico study of the structural disruption of 14α-demethylase induced by the binding of Terminalia chebula constituents","authors":"N. Rani, Randhir Dahiya, Praveen Kumar, Nandini Verma","doi":"10.2174/2215083810666230710122114","DOIUrl":"https://doi.org/10.2174/2215083810666230710122114","url":null,"abstract":"\u0000\u0000Since ancient times, medicinal plants have been in use in medicine and daily life.\u0000\u0000\u0000\u0000To develop new antifungal compounds with low toxicity and high efficacy followed by high bioavailability, the constituents of Terminalia chebula were studied.\u0000\u0000\u0000\u0000The chemical constituents of the plant were evaluated for antifungal potential via Molergo Virtual Docker against the enzyme 14α-demethylase.\u0000\u0000\u0000\u0000The study depicted that tannins exhibited very good potential against the enzyme and could be used further for lead development.\u0000\u0000\u0000\u0000The study revealed that the plant possessed various constituents with potential antifungal properties and low toxicity.\u0000","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48456142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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