Pub Date : 2022-10-13DOI: 10.20473/j.djmkg.v55.i4.p226-230
Muthiary Nitzschia Nur Iswary Winanto, Irfan Dwiandhono, S. W. Logamarta, Rinawati Satrio, A. Kurniawan
Background: Secondary caries occur due to imperfect plaque control. Prolong the protective and therapeutic effects can be done with restorative materials that release fluoride. Now composite resins have been developed a new restorative hybrid material with new matrix component, namely giomer. Giomer composition containing surface pre reacted glass ionomer (S-PRG) as a major source of fluoride production. Increasing the mechanical strength and minimize microleakage to prevent secondary caries can be done with preheating treatment. Purpose: This study is conducted to determine the effect of preheating temperature on the release of giomer’s fluoride. Methods: This study used 9 cylindrical samples in 10 mm diameter and 2 mm thickness each group, divided into 3 groups and 3 subgroups. Group 1: preheating at 37°C for 30 minutes. Group 2: preheating at 60°C for 30 minutes. Group 3: as a control group (without preheating treatment). Each group divided into 3 subgroups immersion, on day 1, day 7 and day 14 with artificial saliva. Fluoride release test was conducted by Spectrophotometer. IBM's SPSS Statistics used for the Data analysis. Results: The addition of preheating treatment decrease the amount of fluoride release. One-way ANOVA test showed a significant difference (P < 0.05). A significant difference between groups and sub groups showed in LSD test (P < 0.05). Conclusion: The group without preheating treatment has highest fluoride release and the 60°C preheating treatment group was the lowest. Addition of preheating treatment may increase the mechanical strength and minimize microleakage, but also descrease the amount of fluoride release.
{"title":"The effect of giomer’s preheating on fluoride release","authors":"Muthiary Nitzschia Nur Iswary Winanto, Irfan Dwiandhono, S. W. Logamarta, Rinawati Satrio, A. Kurniawan","doi":"10.20473/j.djmkg.v55.i4.p226-230","DOIUrl":"https://doi.org/10.20473/j.djmkg.v55.i4.p226-230","url":null,"abstract":"Background: Secondary caries occur due to imperfect plaque control. Prolong the protective and therapeutic effects can be done with restorative materials that release fluoride. Now composite resins have been developed a new restorative hybrid material with new matrix component, namely giomer. Giomer composition containing surface pre reacted glass ionomer (S-PRG) as a major source of fluoride production. Increasing the mechanical strength and minimize microleakage to prevent secondary caries can be done with preheating treatment. Purpose: This study is conducted to determine the effect of preheating temperature on the release of giomer’s fluoride. Methods: This study used 9 cylindrical samples in 10 mm diameter and 2 mm thickness each group, divided into 3 groups and 3 subgroups. Group 1: preheating at 37°C for 30 minutes. Group 2: preheating at 60°C for 30 minutes. Group 3: as a control group (without preheating treatment). Each group divided into 3 subgroups immersion, on day 1, day 7 and day 14 with artificial saliva. Fluoride release test was conducted by Spectrophotometer. IBM's SPSS Statistics used for the Data analysis. Results: The addition of preheating treatment decrease the amount of fluoride release. One-way ANOVA test showed a significant difference (P < 0.05). A significant difference between groups and sub groups showed in LSD test (P < 0.05). Conclusion: The group without preheating treatment has highest fluoride release and the 60°C preheating treatment group was the lowest. Addition of preheating treatment may increase the mechanical strength and minimize microleakage, but also descrease the amount of fluoride release.","PeriodicalId":11034,"journal":{"name":"Dental Journal (Majalah Kedokteran Gigi)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78678189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-12DOI: 10.20473/j.djmkg.v55.i4.p215-220
I. A. Agung, I. N. Palgunadi
Background: The School Dental Health Efforts or Usaha Kesehatan Gigi Sekolah (UKGS) is a public health effort to maintain and improve the dental and oral health of elementary school students. UKGS is the strategy and the flagship of dental health in schools. The implementation of UKGS involves three elements, namely the Public Health Centre or Pusat Kesehatan Masyarakat (Puskesmas), schools, and parents. The three elements in UKGS are the driving force and restraining force, which greatly affect the quality of UKGS services. Purpose: This study aimed to analyze a strategy that can improve the quality of UKGS at Tabanan Puskesmas. Methods: This research used evaluative research and was analyzed by Kurt Lewin’s Force Field Analysis. Results: The driving forces that have the highest score are good knowledge, the skill of personnel, and guidelines for implementing the UKGS at Puskesmas; whereas the restraining forces that have the highest score are the unavailability of guidebooks and health teacher skills, as well as lack of budget for the UKGS activities. Conclusion: Strategies that can improve the quality of UKGS at Tabanan Puskesmas can be done by utilizing the facilities at the Puskesmas for the UKGS activities in schools, transmitting knowledge and skills from Puskesmas officers to the UKGS staff in schools, and increasing the budget by means of self-help.
背景:学校牙齿健康努力或Usaha Kesehatan Gigi Sekolah (UKGS)是一项旨在维持和改善小学生牙齿和口腔健康的公共卫生努力。UKGS是学校牙齿保健的战略和旗舰。实施UKGS涉及三个要素，即公共卫生中心(Puskesmas)、学校和家长。UKGS的三大要素是驱动力和制约因素，对UKGS的服务质量影响很大。目的:探讨提高塔巴南山药质量的对策。方法:本研究采用评价性研究，采用Kurt Lewin力场分析法进行分析。结果:良好的知识、人员技能和Puskesmas实施UKGS的指导方针是得分最高的驱动力;而得分最高的制约因素是缺乏指南和保健教师技能，以及缺乏英国保健服务处活动的预算。结论:利用Puskesmas的设施在学校开展UKGS活动，将Puskesmas官员的知识和技能传授给学校的UKGS工作人员，以及通过自助方式增加预算，可以制定提高Tabanan Puskesmas UKGS质量的策略。
{"title":"Strategy for improving the quality of School Dental Health Efforts at Tabanan Public Health Center","authors":"I. A. Agung, I. N. Palgunadi","doi":"10.20473/j.djmkg.v55.i4.p215-220","DOIUrl":"https://doi.org/10.20473/j.djmkg.v55.i4.p215-220","url":null,"abstract":"Background: The School Dental Health Efforts or Usaha Kesehatan Gigi Sekolah (UKGS) is a public health effort to maintain and improve the dental and oral health of elementary school students. UKGS is the strategy and the flagship of dental health in schools. The implementation of UKGS involves three elements, namely the Public Health Centre or Pusat Kesehatan Masyarakat (Puskesmas), schools, and parents. The three elements in UKGS are the driving force and restraining force, which greatly affect the quality of UKGS services. Purpose: This study aimed to analyze a strategy that can improve the quality of UKGS at Tabanan Puskesmas. Methods: This research used evaluative research and was analyzed by Kurt Lewin’s Force Field Analysis. Results: The driving forces that have the highest score are good knowledge, the skill of personnel, and guidelines for implementing the UKGS at Puskesmas; whereas the restraining forces that have the highest score are the unavailability of guidebooks and health teacher skills, as well as lack of budget for the UKGS activities. Conclusion: Strategies that can improve the quality of UKGS at Tabanan Puskesmas can be done by utilizing the facilities at the Puskesmas for the UKGS activities in schools, transmitting knowledge and skills from Puskesmas officers to the UKGS staff in schools, and increasing the budget by means of self-help.","PeriodicalId":11034,"journal":{"name":"Dental Journal (Majalah Kedokteran Gigi)","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76994609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-12DOI: 10.20473/j.djmkg.v55.i4.p194-199
Alvionika Nadyah Qotrunnada, T. Indriana, Jane Kosasih, Meiske Margaretha, Mei Syafriadi
Background: One of the benign salivary gland tumors is Warthin’s tumor, which is a benign tumor consisting of a papillary cystic structure covered by a double epithelial layer cells and lymphoid stroma with germinal center. Several cases have reported the Warthin’s tumor transformation into a malignant tumor such as lymphoma that develops from their stromal. Expression of cytotoxic T-lymphocyte antigen 4 (CTLA-4) as part of the immune checkpoint when highly expressed leads to a more rapid development or progression of tumors. Purpose: To analyze CTLA-4 expression in Warthin’s tumors associated with the pathogenesis of its growth through an escape mechanism from immune checkpoints and analyze based on CTLA expression whether this marker has the potential to be used as immunotherapy by administering anti CTLA-4. Methods: The tissue sections slides of Warthin’s tumor (n=8) were stained with Hematoxylin Eosin and immunostained with Recombinant Anti-CTLA4 antibody [CAL49] (ab237712). The slide with positive CTLA-4 is shown as staining on the cell membrane and/or cytoplasm. Observations were carried out using Optilab. The result is presented as figures. Results: Tumor cells expressed of CTLA-4 show in cytoplasm and/or cell membranes of the epithelial and stromal components of Warthin’s lymphoid. CTLA-4 is expressed lymphoid stroma, which is associated with inhibition of T cell activity against tumor cells, while the exact mechanism of CTLA-4 expression in epithelial components is not known but is thought to induce tumorigenesis and inhibit apoptosis. Conclusion: CTLA-4 is expressed in epithelial and stromal cells of Warthin’s tumor and this expression indicates that Warthin’s tumor cell growth is through the escape mechanism of the CTLA-4 check point immune. Further research is necessary to investigate whether CTLA-4 expression in lymphoid stroma has relate to their transformation toward a malignant tumor of lymphoma.
{"title":"Role of cytotoxic T-lymphocyte antigen 4 (CTLA-4) expression in the pathogenesis of Warthin’s tumor growth","authors":"Alvionika Nadyah Qotrunnada, T. Indriana, Jane Kosasih, Meiske Margaretha, Mei Syafriadi","doi":"10.20473/j.djmkg.v55.i4.p194-199","DOIUrl":"https://doi.org/10.20473/j.djmkg.v55.i4.p194-199","url":null,"abstract":"Background: One of the benign salivary gland tumors is Warthin’s tumor, which is a benign tumor consisting of a papillary cystic structure covered by a double epithelial layer cells and lymphoid stroma with germinal center. Several cases have reported the Warthin’s tumor transformation into a malignant tumor such as lymphoma that develops from their stromal. Expression of cytotoxic T-lymphocyte antigen 4 (CTLA-4) as part of the immune checkpoint when highly expressed leads to a more rapid development or progression of tumors. Purpose: To analyze CTLA-4 expression in Warthin’s tumors associated with the pathogenesis of its growth through an escape mechanism from immune checkpoints and analyze based on CTLA expression whether this marker has the potential to be used as immunotherapy by administering anti CTLA-4. Methods: The tissue sections slides of Warthin’s tumor (n=8) were stained with Hematoxylin Eosin and immunostained with Recombinant Anti-CTLA4 antibody [CAL49] (ab237712). The slide with positive CTLA-4 is shown as staining on the cell membrane and/or cytoplasm. Observations were carried out using Optilab. The result is presented as figures. Results: Tumor cells expressed of CTLA-4 show in cytoplasm and/or cell membranes of the epithelial and stromal components of Warthin’s lymphoid. CTLA-4 is expressed lymphoid stroma, which is associated with inhibition of T cell activity against tumor cells, while the exact mechanism of CTLA-4 expression in epithelial components is not known but is thought to induce tumorigenesis and inhibit apoptosis. Conclusion: CTLA-4 is expressed in epithelial and stromal cells of Warthin’s tumor and this expression indicates that Warthin’s tumor cell growth is through the escape mechanism of the CTLA-4 check point immune. Further research is necessary to investigate whether CTLA-4 expression in lymphoid stroma has relate to their transformation toward a malignant tumor of lymphoma.","PeriodicalId":11034,"journal":{"name":"Dental Journal (Majalah Kedokteran Gigi)","volume":"70 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88007674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-12DOI: 10.20473/j.djmkg.v55.i4.p240-245
F. T. Handayani, I. A. Evangelina
Background: Impacted maxillary anterior teeth are a problem that has a significant impact on the aesthetics of the smile, dental arches, and occlusion. Teeth that have higher tendencies to get impacted are third molars, maxillary central incisors, maxillary canines, and mandibular premolars. Impacted teeth with severe root dilacerations are usually extracted surgically, then the space will be closed by orthodontic treatment or using a prosthesis. Purpose: This study aims to report the successful orthodontic traction of mesially 90° dilacerated root of impacted maxillary canine. Case: A 15-year-old female patient with the chief complaint of an unerupted left maxillary canine. Intraoral examination showed a class I molar relationship on both sides, a unilateral crossbite on the right side, 8 mm spacing between the maxillary left lateral incisor and the premolar. Also, mild crowding was found on both upper and lower anterior segments. CBCT results showed a left maxillary canine was palatally semi-vertical impacted and had a mesially 90° dilacerated root. A significant stress concentration occurred at the middle and apical of the dilacerated root apex when exposed to orthodontic force; this tends to be a higher potential for resorption. Case Management: The impacted dilacerated canine was successfully moved to the proper position by combining crown exposure surgery, orthodontic traction using continuous light force, and gingivectomy. Furthermore, traction was held using a gold chain combined with an elastic thread tied initially to a modified stainless-steel main archwire; this was followed by piggyback tandem wire and a vertical 3/16” light elastic traction. Conclusion: The patient showed successful traction of the canine in less than six months. In addition, the unilateral posterior crossbite was corrected and functional occlusion was achieved. That canine showed good orthodontic and periodontal stability at one-year follow-up, without any evidence of root resorption.
{"title":"Successful traction of a mesially 90° dilacerated root of impacted maxillary canine: A case report","authors":"F. T. Handayani, I. A. Evangelina","doi":"10.20473/j.djmkg.v55.i4.p240-245","DOIUrl":"https://doi.org/10.20473/j.djmkg.v55.i4.p240-245","url":null,"abstract":"Background: Impacted maxillary anterior teeth are a problem that has a significant impact on the aesthetics of the smile, dental arches, and occlusion. Teeth that have higher tendencies to get impacted are third molars, maxillary central incisors, maxillary canines, and mandibular premolars. Impacted teeth with severe root dilacerations are usually extracted surgically, then the space will be closed by orthodontic treatment or using a prosthesis. Purpose: This study aims to report the successful orthodontic traction of mesially 90° dilacerated root of impacted maxillary canine. Case: A 15-year-old female patient with the chief complaint of an unerupted left maxillary canine. Intraoral examination showed a class I molar relationship on both sides, a unilateral crossbite on the right side, 8 mm spacing between the maxillary left lateral incisor and the premolar. Also, mild crowding was found on both upper and lower anterior segments. CBCT results showed a left maxillary canine was palatally semi-vertical impacted and had a mesially 90° dilacerated root. A significant stress concentration occurred at the middle and apical of the dilacerated root apex when exposed to orthodontic force; this tends to be a higher potential for resorption. Case Management: The impacted dilacerated canine was successfully moved to the proper position by combining crown exposure surgery, orthodontic traction using continuous light force, and gingivectomy. Furthermore, traction was held using a gold chain combined with an elastic thread tied initially to a modified stainless-steel main archwire; this was followed by piggyback tandem wire and a vertical 3/16” light elastic traction. Conclusion: The patient showed successful traction of the canine in less than six months. In addition, the unilateral posterior crossbite was corrected and functional occlusion was achieved. That canine showed good orthodontic and periodontal stability at one-year follow-up, without any evidence of root resorption.","PeriodicalId":11034,"journal":{"name":"Dental Journal (Majalah Kedokteran Gigi)","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89767311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-12DOI: 10.20473/j.djmkg.v55.i4.p200-203
Helsa Alyayuan, J. Budiman
Background: Gender determination is an important aspect of human biologic profile identification. The human skull is part of the body that has many gender indicators. Lateral cephalogram is used for human skull analysis because of its morphological biologic details, including gender. Purpose: The objective of this study was to determine the difference of angular measurements, those are sella-nasion-point A (SNA), sella-nasion-point B (SNB), point A-nasion-point B (ANB), gonial, mandibular plane, glabella-metopion and sella-nasion (GM-SN), glabella-metopion and Frankfort horizontal plane (GM-FHP), and glabella-metopion and basion-nasion (GM-BaN) angles measurement’s results between boys and girls aged 8-12 years. Methods: This study was an observational analytic on cephalometric radiographs in children aged 8-12 years from July-December 2018 using 54 samples from the Faculty of Dentistry Universitas Trisakti’s Oral and Dental Hospital Radiology Installation. Landmarks determination and angular measurement were digitized. The data were analyzed to a univariate test followed by a statistical test using the independent t-test. Results: The independent t-test showed there are no differences between boys’ and girls’ angular measurement results (p > 0.05). Conclusion: There are no differences in the angular measurements results between boys and girls aged 8-12 years.
{"title":"Gender differences in cephalometric angular measurements between boys and girls","authors":"Helsa Alyayuan, J. Budiman","doi":"10.20473/j.djmkg.v55.i4.p200-203","DOIUrl":"https://doi.org/10.20473/j.djmkg.v55.i4.p200-203","url":null,"abstract":"Background: Gender determination is an important aspect of human biologic profile identification. The human skull is part of the body that has many gender indicators. Lateral cephalogram is used for human skull analysis because of its morphological biologic details, including gender. Purpose: The objective of this study was to determine the difference of angular measurements, those are sella-nasion-point A (SNA), sella-nasion-point B (SNB), point A-nasion-point B (ANB), gonial, mandibular plane, glabella-metopion and sella-nasion (GM-SN), glabella-metopion and Frankfort horizontal plane (GM-FHP), and glabella-metopion and basion-nasion (GM-BaN) angles measurement’s results between boys and girls aged 8-12 years. Methods: This study was an observational analytic on cephalometric radiographs in children aged 8-12 years from July-December 2018 using 54 samples from the Faculty of Dentistry Universitas Trisakti’s Oral and Dental Hospital Radiology Installation. Landmarks determination and angular measurement were digitized. The data were analyzed to a univariate test followed by a statistical test using the independent t-test. Results: The independent t-test showed there are no differences between boys’ and girls’ angular measurement results (p > 0.05). Conclusion: There are no differences in the angular measurements results between boys and girls aged 8-12 years.","PeriodicalId":11034,"journal":{"name":"Dental Journal (Majalah Kedokteran Gigi)","volume":"83 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89020978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-12DOI: 10.20473/j.djmkg.v55.i4.p235-239
M. Syahdinda, A. Nugraha, Ari Triwardhani, T. Noor
Background: Maxillary canines play a critical point in creating an aesthetic smile as they support the part of facial muscle. Canines are also the second most frequently impacted teeth after the third molars. In some cases, it is possible to retract canines into their correct position by orthodontics treatment. Purpose: This article highlighted a treatment option with surgical exposure, in which a maxillary canine was impacted. It presented gradual steps from pre-surgical to post-surgical orthodontic treatment. Case: A 16 years old female patient referred to Orthodontic Department by Oral Surgeon for pre-surgical orthodontic treatment of her impacted maxillary canine. Case Management: After pre-surgical orthodontic treatment, the impacted canine was surgically exposed by closed technique since open surgical exposure might need excessive removal of the surrounding bone. Traction was given through a gold chain which attached to the palatal surface of the impacted canine. The tooth was ideally positioned with fixed orthodontic appliances. The permanent right maxillary canine was successfully positioned into proper alignment with the remaining teeth. Aesthetic smile was improved. Conclusion: Malocclusion with impacted canine was successfully treated with MBT orthodontic prescription combined with gold chain that can retract the impacted canine into its physiological position and the patient was satisfied with the aesthetic result.
{"title":"Management of impacted maxillary canine with surgical exposure and alignment by orthodontic treatment","authors":"M. Syahdinda, A. Nugraha, Ari Triwardhani, T. Noor","doi":"10.20473/j.djmkg.v55.i4.p235-239","DOIUrl":"https://doi.org/10.20473/j.djmkg.v55.i4.p235-239","url":null,"abstract":"Background: Maxillary canines play a critical point in creating an aesthetic smile as they support the part of facial muscle. Canines are also the second most frequently impacted teeth after the third molars. In some cases, it is possible to retract canines into their correct position by orthodontics treatment. Purpose: This article highlighted a treatment option with surgical exposure, in which a maxillary canine was impacted. It presented gradual steps from pre-surgical to post-surgical orthodontic treatment. Case: A 16 years old female patient referred to Orthodontic Department by Oral Surgeon for pre-surgical orthodontic treatment of her impacted maxillary canine. Case Management: After pre-surgical orthodontic treatment, the impacted canine was surgically exposed by closed technique since open surgical exposure might need excessive removal of the surrounding bone. Traction was given through a gold chain which attached to the palatal surface of the impacted canine. The tooth was ideally positioned with fixed orthodontic appliances. The permanent right maxillary canine was successfully positioned into proper alignment with the remaining teeth. Aesthetic smile was improved. Conclusion: Malocclusion with impacted canine was successfully treated with MBT orthodontic prescription combined with gold chain that can retract the impacted canine into its physiological position and the patient was satisfied with the aesthetic result.","PeriodicalId":11034,"journal":{"name":"Dental Journal (Majalah Kedokteran Gigi)","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76653243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-12DOI: 10.20473/j.djmkg.v55.i4.p186-193
I. Sufiawati, Alamsyah Piliang, Vatchala Rani Ramamoorthy
Background: Oral microbiota has been suggested to have a role in the etiopathogenesis of oral cancer; however, the oral microbiota diversity in patients with oral cancer compared to healthy individuals remains unclear. Purpose: This scoping review aimed to provide an overview of the current evidence regarding the oral microbiota composition colonized in oral cancer patients and its comparison with healthy individuals. Reviews: This study was conducted according to the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines. Eligible studies were searched in PubMed, Scopus, Web of Science, and ScienceDirect databases from January 2015 to March 2022. A total of 20 relevant studies were included according to the inclusion and exclusion criteria, including 14 cross-sectional studies and 6 cohort studies. All studies have identified various oral bacteria, but only one study has detected viruses and parasites diversity. A variety of oral microbiota found were 6 phyla of bacteria, 6 phyla of viruses, 7 phyla of fungi, and 7 phyla of parasitic. Seventeen studies proved that oral microbiota compositions were statistically significant differences compared to healthy controls, but not in 3 studies. Conclusion: The majority of studies showed various oral bacteria in oral cancer patients which were statistically significant difference compared to healthy controls. This study indicates the need for more research to evaluate viruses and parasites composition and diversity in oral cancer patients. Moreover, future research should focus to clarify whether the changes of oral microbial composition as a community may play a critical role in the etiopathogenesis of oral cancer.
背景:口腔微生物群已被认为在口腔癌的发病机制中起作用;然而，与健康个体相比，口腔癌患者的口腔微生物群多样性尚不清楚。目的:本综述旨在概述口腔癌患者口腔微生物群组成的现有证据，并将其与健康个体进行比较。综述:本研究按照系统评价和荟萃分析(PRISMA)指南的首选报告项目进行。从2015年1月到2022年3月，在PubMed、Scopus、Web of Science和ScienceDirect数据库中检索了符合条件的研究。按照纳入和排除标准共纳入相关研究20项，其中横断面研究14项，队列研究6项。所有的研究都发现了各种口腔细菌，但只有一项研究发现了病毒和寄生虫的多样性。口腔微生物群有细菌6门、病毒6门、真菌7门、寄生虫7门。17项研究证明，与健康对照组相比，口腔微生物群组成有统计学显著差异，但3项研究没有。结论:大多数研究显示口腔癌患者的口腔细菌种类繁多，与健康对照组相比差异有统计学意义。本研究提示需要进一步的研究来评估口腔癌患者中病毒和寄生虫的组成和多样性。此外，口腔微生物组成的变化作为一个群落是否可能在口腔癌的发病过程中发挥关键作用，是未来研究的重点。
{"title":"Oral microbiota in oral cancer patients and healthy individuals: A scoping review","authors":"I. Sufiawati, Alamsyah Piliang, Vatchala Rani Ramamoorthy","doi":"10.20473/j.djmkg.v55.i4.p186-193","DOIUrl":"https://doi.org/10.20473/j.djmkg.v55.i4.p186-193","url":null,"abstract":"Background: Oral microbiota has been suggested to have a role in the etiopathogenesis of oral cancer; however, the oral microbiota diversity in patients with oral cancer compared to healthy individuals remains unclear. Purpose: This scoping review aimed to provide an overview of the current evidence regarding the oral microbiota composition colonized in oral cancer patients and its comparison with healthy individuals. Reviews: This study was conducted according to the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines. Eligible studies were searched in PubMed, Scopus, Web of Science, and ScienceDirect databases from January 2015 to March 2022. A total of 20 relevant studies were included according to the inclusion and exclusion criteria, including 14 cross-sectional studies and 6 cohort studies. All studies have identified various oral bacteria, but only one study has detected viruses and parasites diversity. A variety of oral microbiota found were 6 phyla of bacteria, 6 phyla of viruses, 7 phyla of fungi, and 7 phyla of parasitic. Seventeen studies proved that oral microbiota compositions were statistically significant differences compared to healthy controls, but not in 3 studies. Conclusion: The majority of studies showed various oral bacteria in oral cancer patients which were statistically significant difference compared to healthy controls. This study indicates the need for more research to evaluate viruses and parasites composition and diversity in oral cancer patients. Moreover, future research should focus to clarify whether the changes of oral microbial composition as a community may play a critical role in the etiopathogenesis of oral cancer.","PeriodicalId":11034,"journal":{"name":"Dental Journal (Majalah Kedokteran Gigi)","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79029967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: A study with female animal models is important because the system immune of females is remarkably different from the male because of interaction between sex hormone and immune system. Interleukin-17 (IL-17) plays an important role in immune response toward Candida albicans (C. albicans) infection and Erythrocyte Sedimentation Rate (ERS) is an easy and sensitive test to assess the inflammation. Purpose: This study aimed to evaluate C. albicans infection, analyse the IL-17 levels and ESR in a female animal model of oral candidiasis. Methods: Female Wistar rats were used as oral candidiasis animal model. The rats divided into three groups (pre-treatment group (P0), 5th-day post-treatment group (P1) and 8th-day post- treatment group (P1). Each group consists of six rats. After the adaptation period, the P0 was sacrificed. The drinking water of the P1 and P2 was added tetracycline HCl 500mg /1L. On the day before and after inoculation C. albicans, Methylprednisolone was injected. Ten minutes before inoculation with 0.3 ml C. albicans 9.4 x 107/mL, rats were sedated by CPZ 0.7 mg IM. The rats in P1 group were sacrificed after five days and in P2 were sacrificed eight days after inoculation. The IL-17 plasma levels measured by enzyme-linked immunosorbent assay (ELISA), decreased on the 5th day but not on the 8th-day post-treatment. The obtained data were analyzed by parametric and non-parametric tests according to normality and homogeneity of the data with p<0.05. Results: The colony forming unit (CFU) of C. albicans collected over the mouth on increased almost 8-fold and on 8th-day post-treatment almost 3-fold compared with pre-treatment. The ESR increased on the 8th day but not on the 5th-day post-treatment. Conclusion: The IL-17 level was decreased on the 3rd day, ESR increased on eight days after inoculation of C. albicans in female rats’ model of oral candidiasis.
{"title":"IL-17 plasma levels and erythrocyte sedimentation rate on oral candidiasis animal model","authors":"Erna Sulistyani, Iin Eliana Triwahyuni, Happy Harmono, Lisa Miftakhul Janna, Saikha Adila Azzah, Muchamad Ziyad Afif, Ainunnusak Ayuningtyas","doi":"10.20473/j.djmkg.v55.i4.p209-214","DOIUrl":"https://doi.org/10.20473/j.djmkg.v55.i4.p209-214","url":null,"abstract":"Background: A study with female animal models is important because the system immune of females is remarkably different from the male because of interaction between sex hormone and immune system. Interleukin-17 (IL-17) plays an important role in immune response toward Candida albicans (C. albicans) infection and Erythrocyte Sedimentation Rate (ERS) is an easy and sensitive test to assess the inflammation. Purpose: This study aimed to evaluate C. albicans infection, analyse the IL-17 levels and ESR in a female animal model of oral candidiasis. Methods: Female Wistar rats were used as oral candidiasis animal model. The rats divided into three groups (pre-treatment group (P0), 5th-day post-treatment group (P1) and 8th-day post- treatment group (P1). Each group consists of six rats. After the adaptation period, the P0 was sacrificed. The drinking water of the P1 and P2 was added tetracycline HCl 500mg /1L. On the day before and after inoculation C. albicans, Methylprednisolone was injected. Ten minutes before inoculation with 0.3 ml C. albicans 9.4 x 107/mL, rats were sedated by CPZ 0.7 mg IM. The rats in P1 group were sacrificed after five days and in P2 were sacrificed eight days after inoculation. The IL-17 plasma levels measured by enzyme-linked immunosorbent assay (ELISA), decreased on the 5th day but not on the 8th-day post-treatment. The obtained data were analyzed by parametric and non-parametric tests according to normality and homogeneity of the data with p<0.05. Results: The colony forming unit (CFU) of C. albicans collected over the mouth on increased almost 8-fold and on 8th-day post-treatment almost 3-fold compared with pre-treatment. The ESR increased on the 8th day but not on the 5th-day post-treatment. Conclusion: The IL-17 level was decreased on the 3rd day, ESR increased on eight days after inoculation of C. albicans in female rats’ model of oral candidiasis.","PeriodicalId":11034,"journal":{"name":"Dental Journal (Majalah Kedokteran Gigi)","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75017201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-01DOI: 10.20473/j.djmkg.v55.i3.p179-185
M. Ari, Harry Laksono, Valerian Laksono, R. Sanjaya, T. Pramesti, R. Sitalaksmi
Background: Complete dentures can improve the quality of life of edentulous patients. The selection of a suitable articulator and an impression technique is important to construct a stable and retentive complete denture with good occlusion. The use of a semiadjustable articulator ensures that the dentures can be constructed such that their movement closely resembles the patient’s physiological movements. The effective suction method can ensure the development of the border seal according to the patient’s anatomical condition. The use of a semi-adjustable articulator along with an effective suction method is expected to provide good results in the construction of a complete denture. Purpose: This report aimed to describe the management of individual complete dentures in the flat mandibular ridge using a semi-adjustable articulator along with an effective suction method. Case: A 69-year-old female patient came with a chief complaint of her old dentures being unusable and wanted new dentures made. The patient’s general condition was good, and the last extraction was done three months prior to the patient’s arrival. The mandibular posterior alveolar ridge showed dextral tapering and sinistral flatness. Case Management: A complete denture with an acrylic base was fabricated using a semi-adjustable articulator along with an effective suction method. Conclusion: Flat ridge case management using a semi-adjustable articulator with an effective suction method can improve complete denture retention and stability.
{"title":"Management of a complete denture in the flat mandibular ridge using a semi-adjustable articulator along with an effective suction method","authors":"M. Ari, Harry Laksono, Valerian Laksono, R. Sanjaya, T. Pramesti, R. Sitalaksmi","doi":"10.20473/j.djmkg.v55.i3.p179-185","DOIUrl":"https://doi.org/10.20473/j.djmkg.v55.i3.p179-185","url":null,"abstract":"Background: Complete dentures can improve the quality of life of edentulous patients. The selection of a suitable articulator and an impression technique is important to construct a stable and retentive complete denture with good occlusion. The use of a semiadjustable articulator ensures that the dentures can be constructed such that their movement closely resembles the patient’s physiological movements. The effective suction method can ensure the development of the border seal according to the patient’s anatomical condition. The use of a semi-adjustable articulator along with an effective suction method is expected to provide good results in the construction of a complete denture. Purpose: This report aimed to describe the management of individual complete dentures in the flat mandibular ridge using a semi-adjustable articulator along with an effective suction method. Case: A 69-year-old female patient came with a chief complaint of her old dentures being unusable and wanted new dentures made. The patient’s general condition was good, and the last extraction was done three months prior to the patient’s arrival. The mandibular posterior alveolar ridge showed dextral tapering and sinistral flatness. Case Management: A complete denture with an acrylic base was fabricated using a semi-adjustable articulator along with an effective suction method. Conclusion: Flat ridge case management using a semi-adjustable articulator with an effective suction method can improve complete denture retention and stability.","PeriodicalId":11034,"journal":{"name":"Dental Journal (Majalah Kedokteran Gigi)","volume":"282 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77862422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-01DOI: 10.20473/j.djmkg.v55.i3.p120-124
Ebru Akleyin, C. O. Sarıyıldız, I. Yavuz, İ. Toptancı
Background: The amount and quality of saliva play important roles in maintaining an intraoral bacterial balance. The quality of saliva is defined by its buffering capacity, viscosity, pH and protein content. The amount of saliva is usually related to the flow rate. Purpose: This study aimed to compare the flow rate, pH, viscosity and buffering capacity of saliva as well as plaque formation in children before and after dental treatment. Methods: Saliva samples were taken from paediatric patients before their treatments and one month after their dental treatments had ended, and these saliva samples were then analysed. For each sample analysis, the GC Saliva-Check Buffer kit (GC Corporation, Tokyo, Japan) was used to evaluate buffering capacity, pH and flow rate, and the GC Saliva-Check Mutans kit (GC Corporation, Tokyo, Japan) was used for the determination of Streptococcus Mutans. GC Tri Plaque ID gel (GC Corporation, Tokyo, Japan) was applied to evaluate plaque maturation. Results: The pre-treatment buffering capacity, pH and viscosity sample values were found to be significantly lower than the post-treatment values (p<0.05). No statistically significant difference was determined in the amount of saliva pre- and post-treatment (p>0.05). When examining plaque maturation, it was determined that all of the post-treatment plaque was pink. Conclusion: This study showed that the pH, viscosity and buffering capacity of saliva had increased significantly post-treatment and that the formation of plaque had decreased in children with active caries after all their dental treatments had been completed.
背景:唾液的数量和质量在维持口腔内细菌平衡中起着重要作用。唾液的质量是由它的缓冲能力、粘度、pH值和蛋白质含量决定的。唾液的量通常与流速有关。目的:比较儿童口腔治疗前后唾液流速、pH值、黏度、缓冲能力及牙菌斑形成情况。方法:对治疗前和治疗结束后1个月儿科患者的唾液样本进行分析。对于每个样品的分析，使用GC唾液-检查缓冲试剂盒(GC Corporation，东京，日本)评估缓冲容量，pH和流速，并使用GC唾液-检查Mutans试剂盒(GC Corporation，东京，日本)检测变形链球菌。GC Tri斑块ID凝胶(GC Corporation, Tokyo, Japan)用于评估斑块成熟。结果:处理前样品的缓冲容量、pH值和粘度值明显低于处理后(p0.05)。当检查斑块成熟时，确定所有治疗后的斑块都是粉红色的。结论:本研究表明，活动性龋患儿在完成所有牙科治疗后，唾液的pH值、黏度和缓冲能力均显著增加，牙菌斑的形成减少。
{"title":"Saliva analysis in children with active caries before and after dental treatment","authors":"Ebru Akleyin, C. O. Sarıyıldız, I. Yavuz, İ. Toptancı","doi":"10.20473/j.djmkg.v55.i3.p120-124","DOIUrl":"https://doi.org/10.20473/j.djmkg.v55.i3.p120-124","url":null,"abstract":"Background: The amount and quality of saliva play important roles in maintaining an intraoral bacterial balance. The quality of saliva is defined by its buffering capacity, viscosity, pH and protein content. The amount of saliva is usually related to the flow rate. Purpose: This study aimed to compare the flow rate, pH, viscosity and buffering capacity of saliva as well as plaque formation in children before and after dental treatment. Methods: Saliva samples were taken from paediatric patients before their treatments and one month after their dental treatments had ended, and these saliva samples were then analysed. For each sample analysis, the GC Saliva-Check Buffer kit (GC Corporation, Tokyo, Japan) was used to evaluate buffering capacity, pH and flow rate, and the GC Saliva-Check Mutans kit (GC Corporation, Tokyo, Japan) was used for the determination of Streptococcus Mutans. GC Tri Plaque ID gel (GC Corporation, Tokyo, Japan) was applied to evaluate plaque maturation. Results: The pre-treatment buffering capacity, pH and viscosity sample values were found to be significantly lower than the post-treatment values (p<0.05). No statistically significant difference was determined in the amount of saliva pre- and post-treatment (p>0.05). When examining plaque maturation, it was determined that all of the post-treatment plaque was pink. Conclusion: This study showed that the pH, viscosity and buffering capacity of saliva had increased significantly post-treatment and that the formation of plaque had decreased in children with active caries after all their dental treatments had been completed.","PeriodicalId":11034,"journal":{"name":"Dental Journal (Majalah Kedokteran Gigi)","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87320971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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