Dermatology Reports最新文献

Dear Editor, Pilomatricoma is a benign tumor characterized by differentiation from hair matrix cells to hair cortical cells. It commonly occurs on the head and neck in young individuals. Although blistering is rare, when present, it is typically observed on the upper arms, shoulders, and back. The condition is more frequently seen in teenagers and young adults; however, it is rare in young children. [...].

Dear Editor, The occurrence of multiple primary neoplasms in a single patient is rare but well documented, and the incidental discovery of a previously undiagnosed thyroid carcinoma during lymph node dissection for another primary malignancy presents a unique diagnostic challenge. [...].

Psoriasiform eruptions are increasingly reported as adverse events during treatment of atopic dermatitis (AD) with interleukin (IL)-4/IL-13 inhibitors, including dupilumab. These reactions may represent a possible overlap manifestation between AD and psoriasis (PSO), which are two conditions that, according to recent literature, could lie along a clinical spectrum and share certain clinical, pathogenetic, and histological features. We describe the case of a 30-year-old male with lifelong AD who developed psoriasiform plaques on his elbows and knees during dupilumab therapy. After discontinuation of dupilumab and initiation of upadacitinib 15 mg/day, the patient achieved substantial improvement of both AD and psoriasiform eruptions at 6 months. This case highlights dupilumab-induced psoriasiform eruptions and underscores the therapeutic challenges associated with these clinical pictures. Upadacitinib appears to be a possible and effective treatment option for these presentations.

Dear Editor, Jellyfish stings are among the most common marine envenomations worldwide, particularly in coastal tourist regions. They typically cause immediate pain, erythema, and linear urticarial wheals. Although acute effects are well characterized, delayed cutaneous reactions remain under-recognized. These may occur days to weeks later and often mimic insect bites, eczema, or lichen planus. We report a case of delayed papular dermatitis ten days after a jellyfish sting and briefly review the literature. [...].

Several fruits have been identified as allergens and potential triggers for exacerbations of atopic dermatitis (AD). This study evaluated pineapple allergy and sensitization among adult patients with AD and examined the diagnostic accuracy of a locally produced pineapple allergen extract in skin prick tests (SPTs). A total of 30 adult patients with AD, with a mean age of 36.07±10.81 years, were enrolled in the study. Firstly, SPT was performed using a standard pineapple allergen extract manufactured by Astromed® (Astromed Inc., West Warwick, Rhode Island, USA). Subsequently, a second SPT was carried out with the pineapple allergen extract produced by Teaching Industry Allergen Dr. Soetomo General Academic Hospital, Universitas Airlangga (Surabaya, Indonesia). Data were analyzed for diagnostic test accuracy and agreement. The local pineapple SPT had a sensitivity of 33.33% and a specificity of 100%. The test exhibited a positive predictive value (PPV) of 100%, whereas the negative predictive value (NPV) was 93.10%. The agreement between the standard SPT and the local SPT was statistically significant, exhibiting moderate concordance (p=0.002). The Indonesian pineapple allergen extract for SPT can serve as an alternative diagnostic tool to assess pineapple allergy and sensitization in AD patients.

Keloids and bullous pemphigoid (BP) are two clinically and pathophysiologically distinct dermatologic disorders - the former involves abnormal scar formation due to excess collagen deposition, while the latter is an autoimmune blistering disease. We report a case of a 67-year-old man with a 19-year history of abdominal keloids and the subsequent appearance of vesicular skin lesions. Histopathologic examination revealed both keloidal fibrosis and subepidermal blister formation. Serum testing demonstrated elevated anti-BP180 antibody levels. Initial treatment with topical and systemic agents, including neomycin, glycyrrhizin, spironolactone, and minocycline, resulted in limited improvement. Subsequently, dupilumab - a monoclonal antibody against the interleukin (IL)-4 receptor α - was introduced. After two months of dupilumab therapy, the vesicular lesions resolved, keloids stabilized, serum anti-BP180 antibody levels normalized, and the Dermatology Life Quality Index (DLQI) score decreased from 11 to 2.

Dear Editor, Neurothekeoma is a rare, benign, soft tissue tumor that primarily affects the dermis. Initially described as a variant of nerve sheath myxoma, it was later recognized as a distinct entity because of its histopathological and immunohistochemical differences, as it is thought to be derived from fibroblast. It is most commonly observed in children and young adults, is more frequent in females, and typically arises in the head, neck, and upper extremities. [...].

We present the case of an 82-year-old woman with a basal cell carcinoma, whose excision resulted in a 6×4 cm defect, which was reconstructed using a bilobed flap. The aim of this flap was to maintain the aesthetic boundaries of the forehead, either keeping symmetry with the contralateral side with minimal distortion, or taking advantage of the best color match of adjacent tissue.

Leukonychia refers to the whitening of the nail plate. We identified 22 cases reported in the literature. This study presents two cases of idiopathic leukonychia from Saudi Arabia, which, to our knowledge, are the first reported cases in the region. The first case involves a 26-year-old male with a decade-long history of white discoloration affecting all fingernails. He exhibited low vitamin B12 and elevated thyroid-stimulating hormone (TSH) levels. The second case involves a 23-year-old female with asymptomatic white discoloration on five fingernails and a positive family history of leukonychia in her younger brother. This case series contributes to the limited knowledge of true leukonychia and emphasizes the importance of recognizing its benign nature and distinguishing it from other nail disorders.

Dermatomyositis (DM) is a rare autoimmune disease characterized by inflammatory involvement of skin and muscles, often associated with malignancy, particularly in the presence of anti-transcription intermediary factor 1 gamma (TIF-1γ) antibodies. This case report describes a 57-year-old Senegalese man with anti-TIF-1γ-positive DM and colorectal adenocarcinoma with liver metastases, presenting with severe dermatological symptoms such as ulcerations, the "red on white" sign, and scalp pustulosis, as well as systemic features including dysphagia and muscle weakness. Diagnosis was confirmed through clinical evaluation, serological testing, and histopathology. Treatment with corticosteroids, intravenous immunoglobulin (IVIG), and surgical tumor resection led to significant improvement. This case underscores the importance of recognizing DM's dermatological signs, conducting thorough malignancy screening, and implementing a multidisciplinary approach for effective management and improved outcomes, given the rarity of the association with colorectal cancer.