O. Abu-Hammad, Diana Arabiat, Nebras Althagafi, Rawah Eshky, Abdalla Abu-Hammad, Abdul-Raheem Jaber, Abdel Rahman Jaber, N. Dar-Odeh
Aim. This meta-analysis estimates the prevalence of sexually transmitted diseases (STIs) and HIV infection among male patients diagnosed with Monkeypox during the 2022 outbreak. The study also explores contextual factors associated with higher risk of monkeypox infection. Methods. A systematic review of literature was initially conducted through PubMed/ Medline, Scopus, and Google Scholar to retrieve observational studies describing demographics and medical characteristics of Monkeypox patients affected in the 2022 outbreak. The System for the Unified Management, Assessment, and Review of Information -Joanna Briggs Institute (SUMARI JBI) guidelines was used to conduct the meta-analysis of this review. All data relevant to prevalence of HIV and STIs in male patients diagnosed with Monkeypox were extracted and exported into the JBI SUMARI. To assess point prevalence of HIV and STIs, we used the Freeman-Tukey-type arcsine square root transformation to stabilize the variances of the raw proportions. All estimates were weighted and pooled by the inverse variance using a fixed-effects model. We then used a random model to account for sampling variation and reported heterogeneity in effect size noted across studies in the fixed-effect model. The I2 test statistic and P values were used to measure the heterogeneity between studies. Values of I2 test statistic results were interpreted as follows: low (25%), moderate (50%) and high (75%). Results. Six studies from Spain and the UK met the inclusion criteria. These studies described a total of 541 male patients with monkeypox, 214 of them were positive for HIV and 255 had other STIs. Overall estimated prevalence of HIV and STIs was 40% (95% CI = 0.31%, 0.50%; ᵡ2 = 15) and 43% (95% CI = 25%, 61%; ᵡ2 = 118), respectively. Outcomes indicated moderate to high heterogeneity in the overall analyses. Conclusions. Approximately four in ten male patients affected in the 2022 Monkeypox outbreak had HIV and/or other STIs. Necessary public health measures should target male and female patients who are at risk of Monkeypox infection to prevent the transmission of serious infections such as HIV and other STIs.
目的这项荟萃分析估计了2022年猴痘爆发期间被诊断为猴痘的男性患者中性传播疾病（STI）和艾滋病病毒（HIV）的感染率。研究还探讨了与猴痘感染风险较高相关的背景因素。研究方法首先通过PubMed/ Medline、Scopus和Google Scholar对文献进行系统回顾，检索描述2022年疫情中猴痘患者的人口统计学和医学特征的观察性研究。本综述采用乔安娜-布里格斯研究所信息统一管理、评估和审查系统（SUMARI JBI）指南进行荟萃分析。所有与被诊断为猴痘的男性患者中 HIV 和 STI 感染率相关的数据都被提取并导出到 JBI SUMARI 中。为了评估 HIV 和 STI 的点流行率，我们使用了 Freeman-Tukey-type arcsine 平方根变换来稳定原始比例的方差。使用固定效应模型对所有估计值进行加权并按反方差进行汇总。然后，我们使用随机模型来解释抽样差异，并报告了固定效应模型中各研究效应大小的异质性。我们使用 I2 检验统计量和 P 值来衡量研究之间的异质性。I2 检验统计结果的数值解释如下：低（25%）、中（50%）和高（75%）。结果。来自西班牙和英国的六项研究符合纳入标准。这些研究共描述了541名猴痘男性患者，其中214人HIV检测呈阳性，255人患有其他性传播疾病。HIV和性传播感染的总体估计发病率分别为40%（95% CI = 0.31%，0.50%；ᵡ2 = 15）和43%（95% CI = 25%，61%；ᵡ2 = 118）。总体分析结果显示存在中度到高度异质性。结论在 2022 年猴痘疫情中，每 10 名男性患者中约有 4 人感染了 HIV 和/或其他性传播疾病。必要的公共卫生措施应针对有感染猴痘风险的男性和女性患者，以防止艾滋病毒和其他性传播疾病等严重感染的传播。
{"title":"Sexually transmitted diseases and HIV co-infection among adult male patients in the 2022 monkeypox outbreak: a systematic review and meta-analysis","authors":"O. Abu-Hammad, Diana Arabiat, Nebras Althagafi, Rawah Eshky, Abdalla Abu-Hammad, Abdul-Raheem Jaber, Abdel Rahman Jaber, N. Dar-Odeh","doi":"10.4081/dr.2024.9860","DOIUrl":"https://doi.org/10.4081/dr.2024.9860","url":null,"abstract":"Aim. This meta-analysis estimates the prevalence of sexually transmitted diseases (STIs) and HIV infection among male patients diagnosed with Monkeypox during the 2022 outbreak. The study also explores contextual factors associated with higher risk of monkeypox infection. Methods. A systematic review of literature was initially conducted through PubMed/ Medline, Scopus, and Google Scholar to retrieve observational studies describing demographics and medical characteristics of Monkeypox patients affected in the 2022 outbreak. The System for the Unified Management, Assessment, and Review of Information -Joanna Briggs Institute (SUMARI JBI) guidelines was used to conduct the meta-analysis of this review. All data relevant to prevalence of HIV and STIs in male patients diagnosed with Monkeypox were extracted and exported into the JBI SUMARI. To assess point prevalence of HIV and STIs, we used the Freeman-Tukey-type arcsine square root transformation to stabilize the variances of the raw proportions. All estimates were weighted and pooled by the inverse variance using a fixed-effects model. We then used a random model to account for sampling variation and reported heterogeneity in effect size noted across studies in the fixed-effect model. The I2 test statistic and P values were used to measure the heterogeneity between studies. Values of I2 test statistic results were interpreted as follows: low (25%), moderate (50%) and high (75%). Results. Six studies from Spain and the UK met the inclusion criteria. These studies described a total of 541 male patients with monkeypox, 214 of them were positive for HIV and 255 had other STIs. Overall estimated prevalence of HIV and STIs was 40% (95% CI = 0.31%, 0.50%; ᵡ2 = 15) and 43% (95% CI = 25%, 61%; ᵡ2 = 118), respectively. Outcomes indicated moderate to high heterogeneity in the overall analyses. Conclusions. Approximately four in ten male patients affected in the 2022 Monkeypox outbreak had HIV and/or other STIs. Necessary public health measures should target male and female patients who are at risk of Monkeypox infection to prevent the transmission of serious infections such as HIV and other STIs.","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139801423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C. Zengarini, A. Guglielmo, Martina Mussi, Andrea Filippini, S. Vaccari, B. M. Piraccini, A. Pileri
This case report describes an 83-year-old patient with a history of non-melanoma skin cancer who presented with a violaceous, painless nodule on the neck. Dermoscopic examination and subsequent biopsy revealed a Small/Medium CD4+ T-cell lymphoproliferative disorder (SMPLPD) of the skin. Although excision was initially recommended, the patient opted for treatment with CO2 laser ablation. The procedure had some minor complications but resulted in successful healing. SMPLPDs are a rare skin condition with limited treatment data, and this case suggests that CO2 laser ablation with minimal margins could be a viable alternative for selected patients, reducing bleeding and promoting second-intention healing for small nodules. However, more extensive follow-up data for SMPLPD cases are needed to understand long-term outcomes better.
本病例报告描述的是一名 83 岁的患者，曾患有非黑色素瘤皮肤癌，颈部出现一个剧烈、无痛的结节。皮肤镜检查和随后的活检显示，患者患有小/中型 CD4+ T 细胞淋巴增生性疾病（SMPLPD）。虽然最初建议进行切除，但患者还是选择了二氧化碳激光消融术。手术出现了一些轻微的并发症，但最终成功痊愈。SMPLPD 是一种罕见的皮肤病，治疗数据有限，本病例表明，对于选定的患者来说，边缘最小的 CO2 激光消融术可能是一种可行的替代方法，它可以减少出血，促进小结节的二次愈合。不过，要更好地了解 SMPLPD 病例的长期疗效，还需要更广泛的随访数据。
{"title":"Primary cutaneous CD4+ small/medium T-cell lymphoproliferative disorder nodule successfully treated with laser Co2 ablation: a case report and literature review","authors":"C. Zengarini, A. Guglielmo, Martina Mussi, Andrea Filippini, S. Vaccari, B. M. Piraccini, A. Pileri","doi":"10.4081/dr.2024.9884","DOIUrl":"https://doi.org/10.4081/dr.2024.9884","url":null,"abstract":"This case report describes an 83-year-old patient with a history of non-melanoma skin cancer who presented with a violaceous, painless nodule on the neck. Dermoscopic examination and subsequent biopsy revealed a Small/Medium CD4+ T-cell lymphoproliferative disorder (SMPLPD) of the skin. Although excision was initially recommended, the patient opted for treatment with CO2 laser ablation. The procedure had some minor complications but resulted in successful healing. SMPLPDs are a rare skin condition with limited treatment data, and this case suggests that CO2 laser ablation with minimal margins could be a viable alternative for selected patients, reducing bleeding and promoting second-intention healing for small nodules. However, more extensive follow-up data for SMPLPD cases are needed to understand long-term outcomes better.","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139859486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kara Adistri, Sondang P. Sirait, Rahadi Rihatmadja, Lili Legiawati, Wresti Indriatmi, Siti Rizny Fitriana Saldi
Introduction: Androgenetic alopecia (AGA) is the most common type of hair loss. Treatment options are limited. Microneedling, a minimally invasive technique can enhance hair growth by releasing growth factors. However, standardized protocol regarding the frequency, depth and duration has not been available. This study aims to determine the effectiveness and safety of the combination therapy of microneedling and minoxidil in AGA. Methods: This study was a randomized controlled clinical trial conducted over 12 weeks. Intervention group: a combination therapy of 4-weekly microneedling and 5% minoxidil, and control group got topical 5% minoxidil alone. Hair density and diameter were assessed using FotoFinder® trichoscale every 4 weeks. Results: A total of 36 male participants, between 26-51 years old, with Hamilton-Norwood type III-VI AGA were included. At the end of study, a significant increase in hair density was observed in the intervention group compared to control (95.6 vs 52.4 hair/cm², p<0.001), as was in hair diameter (18 vs 6 μm, p=0.004). Side effects, included itching and transient erythema, were well tolerated. Conclusion: The combination of 4-weekly microneedling and topical 5% minoxidil is effective in increasing both hair density and hair diameter, and safe to use in AGA patients.
简介：雄激素性脱发（AGA）是最常见的脱发类型：雄激素性脱发（AGA）是最常见的脱发类型。治疗方法有限。微针疗法是一种微创技术，可通过释放生长因子促进头发生长。然而，目前还没有关于治疗频率、深度和持续时间的标准化方案。本研究旨在确定微针疗法和米诺地尔联合疗法对 AGA 的有效性和安全性。研究方法本研究是一项随机对照临床试验，为期 12 周。干预组：每4周进行一次微针和5%米诺地尔联合治疗，对照组仅外用5%米诺地尔。每4周使用FotoFinder® Trichoscale评估头发密度和直径。结果研究共纳入了 36 名患有汉密尔顿-诺伍德 III-VI 型 AGA 的男性患者，年龄在 26-51 岁之间。研究结束时，与对照组相比，干预组的毛发密度（95.6 根/平方厘米对 52.4 根/平方厘米，P<0.001）和毛发直径（18 微米对 6 微米，P=0.004）均有显著增加。瘙痒和一过性红斑等副作用的耐受性良好。结论每周 4 次的微针疗法与 5%米诺地尔外用药相结合，可有效增加毛发密度和毛发直径，而且在 AGA 患者中使用安全。
{"title":"Effectiveness and safety of the combination therapy of micro-needling and minoxidil in androgenetic alopecia of Indonesian men: a randomized controlled trial","authors":"Kara Adistri, Sondang P. Sirait, Rahadi Rihatmadja, Lili Legiawati, Wresti Indriatmi, Siti Rizny Fitriana Saldi","doi":"10.4081/dr.2024.9945","DOIUrl":"https://doi.org/10.4081/dr.2024.9945","url":null,"abstract":"Introduction: Androgenetic alopecia (AGA) is the most common type of hair loss. Treatment options are limited. Microneedling, a minimally invasive technique can enhance hair growth by releasing growth factors. However, standardized protocol regarding the frequency, depth and duration has not been available. This study aims to determine the effectiveness and safety of the combination therapy of microneedling and minoxidil in AGA. Methods: This study was a randomized controlled clinical trial conducted over 12 weeks. Intervention group: a combination therapy of 4-weekly microneedling and 5% minoxidil, and control group got topical 5% minoxidil alone. Hair density and diameter were assessed using FotoFinder® trichoscale every 4 weeks. Results: A total of 36 male participants, between 26-51 years old, with Hamilton-Norwood type III-VI AGA were included. At the end of study, a significant increase in hair density was observed in the intervention group compared to control (95.6 vs 52.4 hair/cm², p<0.001), as was in hair diameter (18 vs 6 μm, p=0.004). Side effects, included itching and transient erythema, were well tolerated. Conclusion: The combination of 4-weekly microneedling and topical 5% minoxidil is effective in increasing both hair density and hair diameter, and safe to use in AGA patients.","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139798850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Saba Alsuhaymi, Faisal Alghubaywi, Raghad Alharthi, Afaf Al AlSheikh, M. Aljasser
Background: Medical photography has been utilized in clinical, academic, and research settings. In conservative countries, such as Saudi Arabia, limited data reflect patients’ viewpoints on medical photography. Objectives: To assess patients’ opinions on medical photography and the factors influencing its acceptability. Methods: A cross-sectional study utilizing a self-distributed paper-based questionnaire was performed in the dermatology clinics at King Abdulaziz Medical City (Riyadh, Saudi Arabia) between February 2020 and January 2021. The response rate is 100% as only willing participants were handed a hard-copy survey and then retrieved once completed. Results: A total of 414 Saudi adults were enrolled. Medical photography was highly acceptable, fairly acceptable, and poorly acceptable in 36.7%, 11.6%, and 14.3% of the patients, respectively. Females were more accepting of medical photography than males (p = 0.041). Physicians were the most preferred choice as photographers (83%). Stating all intended use of the photographs was favored by the majority of patients. Using a department-owned camera was essential to 84%. Patients who never had their photographs taken previously were more unaccepting of medical photography than those with prior experience (p = 0.037). Limitations: the study was conducted at a single center; therefore, it may not represent the entire population. Conclusions: Medical photography is acceptable to the majority of patients. Meeting popular preferences, including physicians as photographers, using department-owned cameras, and stating all possible uses of the photographs may enhance patients’ experience. The findings offer insight for developing a standardized framework that is suitable for both patients and physicians.
{"title":"Perception and acceptance of medical photography among Arab dermatology patients: a cross-sectional analysis","authors":"Saba Alsuhaymi, Faisal Alghubaywi, Raghad Alharthi, Afaf Al AlSheikh, M. Aljasser","doi":"10.4081/dr.2024.9925","DOIUrl":"https://doi.org/10.4081/dr.2024.9925","url":null,"abstract":"Background: Medical photography has been utilized in clinical, academic, and research settings. In conservative countries, such as Saudi Arabia, limited data reflect patients’ viewpoints on medical photography. Objectives: To assess patients’ opinions on medical photography and the factors influencing its acceptability. Methods: A cross-sectional study utilizing a self-distributed paper-based questionnaire was performed in the dermatology clinics at King Abdulaziz Medical City (Riyadh, Saudi Arabia) between February 2020 and January 2021. The response rate is 100% as only willing participants were handed a hard-copy survey and then retrieved once completed. Results: A total of 414 Saudi adults were enrolled. Medical photography was highly acceptable, fairly acceptable, and poorly acceptable in 36.7%, 11.6%, and 14.3% of the patients, respectively. Females were more accepting of medical photography than males (p = 0.041). Physicians were the most preferred choice as photographers (83%). Stating all intended use of the photographs was favored by the majority of patients. Using a department-owned camera was essential to 84%. Patients who never had their photographs taken previously were more unaccepting of medical photography than those with prior experience (p = 0.037). Limitations: the study was conducted at a single center; therefore, it may not represent the entire population. Conclusions: Medical photography is acceptable to the majority of patients. Meeting popular preferences, including physicians as photographers, using department-owned cameras, and stating all possible uses of the photographs may enhance patients’ experience. The findings offer insight for developing a standardized framework that is suitable for both patients and physicians.","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139859193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ö. Yalçın, Mine İlayda Şengör Aygün, Elif Moustafa, Ezgi Aktaş
Background. Morphea is a rare autoimmune disease that often affects the skin and subcutaneous tissue. Objective. The aim of our study is to reveal the relationship between demographic characteristics of the patients, location of the lesions, clinical subtype of morphea and histopathological findings. Methods. We studied 78 patients diagnosed with morphea between 2016 and 2022 at the Department of Pathology, Prof. Dr. Cemil Taşcıoğlu City Hospital. 72 patients were included in the study. Hematoxylin and Eosin stain slides of cases were retrieved from the pathology archive and were evaluated by two pathologists under blinded conditions. Flattening of rete ridges, location of inflammatory infiltrate, grade of inflammatory infiltrate, presence of plasma cells, presence of eosinophils, homogenization of dermal collagen, decrease of skin appendages, basal pigmentation and melanin incontinence were evaluated. Statistical analyses were performed using SPSSv.20. Results. The most common clinical presentation was plaque type(87.5%) and histopathological findings were homogenization of dermal collagen(100%) and decrease of skin appendages (98.7%). Flattening of the rete ridges was observed in 46.2% of the patients. Severity of the inflammatory infiltrate was found to be higher in these patients(p=0.028). Basal pigmentation was observed in 59% of the patients. Line sign was more common in lower extremity lesions among all localizations (p=0.015). Conclusions. The histopathologic features of morphea are variable and confusing. Particularly, in cases with collagen homogenization, morphea should be considered in differential diagnosis with clinical correlation. In addition, the ‘line’ sign could be helpful for identifying lesions located in the lower extremities.
{"title":"Histopathologic spectrum of morphea: a single-center retrospective study","authors":"Ö. Yalçın, Mine İlayda Şengör Aygün, Elif Moustafa, Ezgi Aktaş","doi":"10.4081/dr.2024.9915","DOIUrl":"https://doi.org/10.4081/dr.2024.9915","url":null,"abstract":"Background. Morphea is a rare autoimmune disease that often affects the skin and subcutaneous tissue. Objective. The aim of our study is to reveal the relationship between demographic characteristics of the patients, location of the lesions, clinical subtype of morphea and histopathological findings. Methods. We studied 78 patients diagnosed with morphea between 2016 and 2022 at the Department of Pathology, Prof. Dr. Cemil Taşcıoğlu City Hospital. 72 patients were included in the study. Hematoxylin and Eosin stain slides of cases were retrieved from the pathology archive and were evaluated by two pathologists under blinded conditions. Flattening of rete ridges, location of inflammatory infiltrate, grade of inflammatory infiltrate, presence of plasma cells, presence of eosinophils, homogenization of dermal collagen, decrease of skin appendages, basal pigmentation and melanin incontinence were evaluated. Statistical analyses were performed using SPSSv.20. Results. The most common clinical presentation was plaque type(87.5%) and histopathological findings were homogenization of dermal collagen(100%) and decrease of skin appendages (98.7%). Flattening of the rete ridges was observed in 46.2% of the patients. Severity of the inflammatory infiltrate was found to be higher in these patients(p=0.028). Basal pigmentation was observed in 59% of the patients. Line sign was more common in lower extremity lesions among all localizations (p=0.015). Conclusions. The histopathologic features of morphea are variable and confusing. Particularly, in cases with collagen homogenization, morphea should be considered in differential diagnosis with clinical correlation. In addition, the ‘line’ sign could be helpful for identifying lesions located in the lower extremities.","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139859172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F. Savoia, M. Medri, A. Passardi, Davide Melandri, I. Stanganelli
Reticulate pigmentary disorders can be classified into inherited or acquired and cutaneous drug- induced reticulate hyperpigmentation belongs to this last group. The list of the drugs involved is constantly increasing and chemotherapy agents are frequently implicated. We report a new case of chemotherapy-related reticulate hyperpigmentation to gemcitabine, even though a previous chemotherapy with nanoparticle, albumin-bound (Nab®) paclitaxel and gemcitabine may have promoted the onset of the disease. Reassurance of the patients is important in these cases, in order to continue the chemotherapy, and gradual fading of the hyperpigmentation is usually observed, as in our case.
{"title":"Gemcitabine, a rare cause of chemotherapy-related reticulate hyperpigmentation","authors":"F. Savoia, M. Medri, A. Passardi, Davide Melandri, I. Stanganelli","doi":"10.4081/dr.2024.9872","DOIUrl":"https://doi.org/10.4081/dr.2024.9872","url":null,"abstract":"Reticulate pigmentary disorders can be classified into inherited or acquired and cutaneous drug- induced reticulate hyperpigmentation belongs to this last group. The list of the drugs involved is constantly increasing and chemotherapy agents are frequently implicated. We report a new case of chemotherapy-related reticulate hyperpigmentation to gemcitabine, even though a previous chemotherapy with nanoparticle, albumin-bound (Nab®) paclitaxel and gemcitabine may have promoted the onset of the disease. Reassurance of the patients is important in these cases, in order to continue the chemotherapy, and gradual fading of the hyperpigmentation is usually observed, as in our case.","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139869604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sarah Gordon, Alison M. Layton, Sandra Fawcett, Kehinde Ross
Acne (syn. acne vulgaris) is a common inflammatory skin disorder associated with puberty and adolescence. Driven by complex interactions between the pilosebaceous unit and Cutibacterium acnes (C. acnes) bacteria, the disease is characterised by comedonal lesions, papules, pustules and nodules that appear predominantly on the face. Acne and sequelae such as scarring and pigment changes affect health-related quality of life negatively. Approvals for nucleic acid therapies (NATs) such as short-interfering RNA (siRNA) drugs and antisense oligonucleotides (ASOs) have surged in recent years, for rare disorders with little or no effective treatments. These advances, along with clinical trials for microRNA (miRNA) modulation in skin contexts, raise the possibility that NATs may have potential for future acne treatment regimens. In this review, we highlight potential miRNA targets for anti-acne therapy. We provide a brief overview of acne pathophysiology and highlight roles of C. acnes. We then focus on recently discovered differential effects of planktonic and biofilm C. acnes on a Toll-like receptor 2 (TLR2) axis spanning miR-146a-5p. We appraise miR-146a-5p in sebocytes before addressing the putative contributions of miR-21-5p, miR-233-3p and miR-150-5p to inflammatory axes in acne. We conclude with translational perspectives and considerations of patient involvement in miRNA-related research for acne.
{"title":"A microRNA focus on acne","authors":"Sarah Gordon, Alison M. Layton, Sandra Fawcett, Kehinde Ross","doi":"10.4081/dr.2024.9902","DOIUrl":"https://doi.org/10.4081/dr.2024.9902","url":null,"abstract":"Acne (syn. acne vulgaris) is a common inflammatory skin disorder associated with puberty and adolescence. Driven by complex interactions between the pilosebaceous unit and Cutibacterium acnes (C. acnes) bacteria, the disease is characterised by comedonal lesions, papules, pustules and nodules that appear predominantly on the face. Acne and sequelae such as scarring and pigment changes affect health-related quality of life negatively. Approvals for nucleic acid therapies (NATs) such as short-interfering RNA (siRNA) drugs and antisense oligonucleotides (ASOs) have surged in recent years, for rare disorders with little or no effective treatments. These advances, along with clinical trials for microRNA (miRNA) modulation in skin contexts, raise the possibility that NATs may have potential for future acne treatment regimens. In this review, we highlight potential miRNA targets for anti-acne therapy. We provide a brief overview of acne pathophysiology and highlight roles of C. acnes. We then focus on recently discovered differential effects of planktonic and biofilm C. acnes on a Toll-like receptor 2 (TLR2) axis spanning miR-146a-5p. We appraise miR-146a-5p in sebocytes before addressing the putative contributions of miR-21-5p, miR-233-3p and miR-150-5p to inflammatory axes in acne. We conclude with translational perspectives and considerations of patient involvement in miRNA-related research for acne.","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139683440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F. Savoia, M. Medri, A. Passardi, Davide Melandri, I. Stanganelli
Reticulate pigmentary disorders can be classified into inherited or acquired and cutaneous drug- induced reticulate hyperpigmentation belongs to this last group. The list of the drugs involved is constantly increasing and chemotherapy agents are frequently implicated. We report a new case of chemotherapy-related reticulate hyperpigmentation to gemcitabine, even though a previous chemotherapy with nanoparticle, albumin-bound (Nab®) paclitaxel and gemcitabine may have promoted the onset of the disease. Reassurance of the patients is important in these cases, in order to continue the chemotherapy, and gradual fading of the hyperpigmentation is usually observed, as in our case.
{"title":"Gemcitabine, a rare cause of chemotherapy-related reticulate hyperpigmentation","authors":"F. Savoia, M. Medri, A. Passardi, Davide Melandri, I. Stanganelli","doi":"10.4081/dr.2024.9872","DOIUrl":"https://doi.org/10.4081/dr.2024.9872","url":null,"abstract":"Reticulate pigmentary disorders can be classified into inherited or acquired and cutaneous drug- induced reticulate hyperpigmentation belongs to this last group. The list of the drugs involved is constantly increasing and chemotherapy agents are frequently implicated. We report a new case of chemotherapy-related reticulate hyperpigmentation to gemcitabine, even though a previous chemotherapy with nanoparticle, albumin-bound (Nab®) paclitaxel and gemcitabine may have promoted the onset of the disease. Reassurance of the patients is important in these cases, in order to continue the chemotherapy, and gradual fading of the hyperpigmentation is usually observed, as in our case.","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139809736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The COVID-19 pandemic has caused a global health crisis, presenting novel challenges while worsening preexisting difficulties for individuals with rare diseases. Internationally, they have experienced disruptions in their medical care, with a lack of access to essential treatments and diagnostics. We focused on the specific challenges faced by individuals living with rare skin diseases in Albania, a country with limited healthcare infrastructure. The pandemic led to a significant decrease in our service, resulting in an 87.1% reduction in patients hospitalized in 2020 compared to 2019. Notable gender and age disparities were observed in hospitalizations, with a shift towards more male patients and a decline in younger age groups seeking medical attention. Innovative approaches such as telemedicine helped maintain care for this vulnerable patient population. Further research is required to understand the long-term impacts of the pandemic on individuals with rare skin diseases and develop strategies for their care in future emergencies.
{"title":"The impact of COVID-19 pandemic on dermatology patients with rare skin diseases","authors":"M. Vargu, Sabina Dedej, E. Vasili","doi":"10.4081/dr.2024.9879","DOIUrl":"https://doi.org/10.4081/dr.2024.9879","url":null,"abstract":"The COVID-19 pandemic has caused a global health crisis, presenting novel challenges while worsening preexisting difficulties for individuals with rare diseases. Internationally, they have experienced disruptions in their medical care, with a lack of access to essential treatments and diagnostics. We focused on the specific challenges faced by individuals living with rare skin diseases in Albania, a country with limited healthcare infrastructure. The pandemic led to a significant decrease in our service, resulting in an 87.1% reduction in patients hospitalized in 2020 compared to 2019. Notable gender and age disparities were observed in hospitalizations, with a shift towards more male patients and a decline in younger age groups seeking medical attention. Innovative approaches such as telemedicine helped maintain care for this vulnerable patient population. Further research is required to understand the long-term impacts of the pandemic on individuals with rare skin diseases and develop strategies for their care in future emergencies.","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139810873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The COVID-19 pandemic has caused a global health crisis, presenting novel challenges while worsening preexisting difficulties for individuals with rare diseases. Internationally, they have experienced disruptions in their medical care, with a lack of access to essential treatments and diagnostics. We focused on the specific challenges faced by individuals living with rare skin diseases in Albania, a country with limited healthcare infrastructure. The pandemic led to a significant decrease in our service, resulting in an 87.1% reduction in patients hospitalized in 2020 compared to 2019. Notable gender and age disparities were observed in hospitalizations, with a shift towards more male patients and a decline in younger age groups seeking medical attention. Innovative approaches such as telemedicine helped maintain care for this vulnerable patient population. Further research is required to understand the long-term impacts of the pandemic on individuals with rare skin diseases and develop strategies for their care in future emergencies.
{"title":"The impact of COVID-19 pandemic on dermatology patients with rare skin diseases","authors":"M. Vargu, Sabina Dedej, E. Vasili","doi":"10.4081/dr.2024.9879","DOIUrl":"https://doi.org/10.4081/dr.2024.9879","url":null,"abstract":"The COVID-19 pandemic has caused a global health crisis, presenting novel challenges while worsening preexisting difficulties for individuals with rare diseases. Internationally, they have experienced disruptions in their medical care, with a lack of access to essential treatments and diagnostics. We focused on the specific challenges faced by individuals living with rare skin diseases in Albania, a country with limited healthcare infrastructure. The pandemic led to a significant decrease in our service, resulting in an 87.1% reduction in patients hospitalized in 2020 compared to 2019. Notable gender and age disparities were observed in hospitalizations, with a shift towards more male patients and a decline in younger age groups seeking medical attention. Innovative approaches such as telemedicine helped maintain care for this vulnerable patient population. Further research is required to understand the long-term impacts of the pandemic on individuals with rare skin diseases and develop strategies for their care in future emergencies.","PeriodicalId":11049,"journal":{"name":"Dermatology Reports","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139870884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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