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Drug Delivery Systems for Natural Medicines in Cancer Therapy. 癌症治疗中天然药物的给药系统。
IF 2.9 4区 医学 Q3 CHEMISTRY, MEDICINAL Pub Date : 2024-07-31 DOI: 10.2174/0115680266315985240710063754
P K Hashim, Naseef Punnoth Poonkuzhi, Nusaiba Madappuram Cheruthu, Mohamed Saher Kuruniyan

Cancer stands as a prominent global cause of mortality, with chemotherapy using synthetic drugs being the predominant treatment method. Despite its high success rate, this approach is constrained by substantial side effects. Herbal medicines, known for their diverse bioactive components, exhibit promising anticancer attributes. The drug delivery systems can improve the precision of delivering these herbal compounds, enhancing efficacy while minimizing potential side effects. Various platforms, such as nanoparticle-based carriers, liposomes, and polymeric micelles, are investigated for encapsulating and delivering herbal components to cancer cells. These systems not only enhance the bioavailability of herbal compounds but also facilitate controlled release, sustained drug circulation, and improved cellular uptake. This comprehensive review focuses on the recent advancement in the field of drug delivery systems employed in the delivery of plant-derived anticancer compounds. It categorizes carriers into organic and inorganic nanoparticles, addressing their application in enhancing the safety and efficacy of plant-derived anticancer compounds alongside associated challenges. The review concludes by outlining recent investigations into drug delivery systems aimed at increasing the efficacy of plant-derived anticancer compounds. Future research in this field should emphasize experiments in animal models and potential clinical translation.

癌症是导致全球死亡的主要原因,使用合成药物的化疗是最主要的治疗方法。尽管化疗的成功率很高,但副作用也很大。中草药以其多种多样的生物活性成分而闻名,具有良好的抗癌特性。给药系统可以提高这些草药化合物的给药精确度,在提高疗效的同时将潜在的副作用降至最低。目前正在研究各种平台,如纳米颗粒载体、脂质体和聚合物胶束,用于封装草药成分并将其输送到癌细胞中。这些系统不仅能提高草药化合物的生物利用度,还能促进药物的控释、持续循环和细胞吸收。本综述重点介绍了用于输送植物抗癌化合物的药物输送系统领域的最新进展。综述将载体分为有机纳米颗粒和无机纳米颗粒,探讨了它们在提高植物抗癌化合物的安全性和有效性方面的应用以及相关挑战。综述最后概述了近期旨在提高植物抗癌化合物疗效的给药系统研究。该领域的未来研究应重视动物模型实验和潜在的临床转化。
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引用次数: 0
Green Synthesis of Bioactive Pyrrole Derivatives via Heterogeneous Catalysts Since 2010. 通过异构催化剂绿色合成具有生物活性的吡咯衍生物,自 2010 年起。
IF 2.9 4区 医学 Q3 CHEMISTRY, MEDICINAL Pub Date : 2024-07-26 DOI: 10.2174/0115680266307696240708115422
Berrichi Amina, Bachir Redouane

Pyrrole derivatives are known as building blocks for the synthesis of biological compounds and pharmaceutical drugs. Several processes were employed to synthesize pyrroles, including Hantzsch, Paal-Knorr, and cycloaddition of dicarbonyl compounds reaction. Using catalysts like nanoparticles, metal salts, and heterogeneous ones was necessary to obtain the targeted pyrrole structure. Also, to afford more active pyrrole compounds, heterocyclic molecules such as imidazole or other rings were used in the synthesis as amines. This review presents heterogeneous catalysts since 2010 for the green synthesis of bioactive pyrroles in a one-pot multi-component reaction. Additionally, each synthetic method included a demonstration of the suggested mechanisms. Diakylacetylenedicarboxylate, dicarbonyl group, amines, furans, and acetylene group are consolidated to yield biological pyrroles through the heterogeneous catalysts. Finally, various parolee-performed activities were displayed, such as antibacterial, anti-inflammatory, analgesic, and other significant activities.

众所周知,吡咯衍生物是合成生物化合物和药物的基础材料。合成吡咯的方法有多种,包括汉茨赫(Hantzsch)、帕尔-克诺尔(Paal-Knorr)和二羰基化合物的环加成反应。要获得目标吡咯结构,必须使用纳米颗粒、金属盐和异质催化剂。此外,为了得到更有活性的吡咯化合物,在合成过程中还使用了咪唑等杂环分子或其他环作为胺。本综述介绍了自 2010 年以来通过一锅多组分反应绿色合成生物活性吡咯的异质催化剂。此外,每种合成方法还包括对建议机制的演示。二烷基乙酰二羧酸酯、二羰基、胺、呋喃和乙炔基通过异质催化剂合并生成生物活性吡咯。最后,研究人员还展示了各种对氨基苯甲酸酯的活性,如抗菌、消炎、镇痛和其他重要活性。
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引用次数: 0
Biological Cargo: Exosomes and their Role in Cancer Progression and Metastasis. 生物货物:外泌体及其在癌症进展和转移中的作用。
IF 2.9 4区 医学 Q3 CHEMISTRY, MEDICINAL Pub Date : 2024-07-09 DOI: 10.2174/0115680266304636240626055711
Siddhant Tripathi, Yashika Sharma, Dileep Kumar

Cancer cells are among the many types of cells that release exosomes, which are nanovesicles. Because of their many potential applications, exosomes have recently garnered much attention from cancer researchers. The bioactive substances that exosomes release as cargo have been the subject of several investigations. The substances in question may operate as biomarkers for diagnosis or affect apoptosis, the immune system, the development and spread of cancer, and other processes. Others have begun to look at exosomes in experimental therapeutic trials because they believe they may be useful in the treatment of cancer. This review started with a short description of exosome biogenesis and key features. Next, the potential of tumor-derived exosomes and oncosomes to influence the immune system throughout the development of cancer, as well as alter tumor microenvironments (TMEs) and pre-metastatic niche creation, was investigated. Finally, there was talk of exosomes' possible use in cancer treatment. Furthermore, there is emerging consensus about the potential application of exosomes to be biological reprogrammers of cancer cells, either as carriers of naturally occurring chemicals, including anticancer medications, or as carriers of anticancer vaccines for immunotherapy as well as boron neutron capture therapy (BNCT). We briefly review the key ideas and logic behind this intriguing therapy recommendation.

癌细胞是释放外泌体(一种纳米微粒)的多种类型细胞之一。由于外泌体有许多潜在用途,因此最近备受癌症研究人员的关注。外泌体作为货物释放的生物活性物质已成为多项研究的主题。这些物质可能是诊断的生物标志物,也可能影响细胞凋亡、免疫系统、癌症的发展和扩散以及其他过程。还有人开始在实验性治疗试验中研究外泌体,因为他们相信外泌体可能有助于治疗癌症。本综述首先简要介绍了外泌体的生物生成和主要特征。接着,探讨了肿瘤衍生的外泌体和内泌体在整个癌症发展过程中影响免疫系统、改变肿瘤微环境(TMEs)和转移前生态位形成的潜力。最后,还谈到了外泌体在癌症治疗中的可能用途。此外,外泌体作为天然化学物质(包括抗癌药物)的载体,或作为用于免疫疗法和硼中子俘获疗法(BNCT)的抗癌疫苗的载体,有可能成为癌细胞的生物重编程器,这一点正在形成共识。我们将简要回顾这一引人入胜的疗法建议背后的主要理念和逻辑。
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引用次数: 0
Recent Developments on the Synthesis of Oxygen- and Sulfur-containing Heterocycles and their Derivatives under Visible Light Induced Reactions. 在可见光诱导反应下合成含氧和含硫杂环及其衍生物的最新进展。
IF 2.9 4区 医学 Q3 CHEMISTRY, MEDICINAL Pub Date : 2024-07-03 DOI: 10.2174/0115680266313243240624071549
Tubai Ghosh, Sougata Santra, Grigory V Zyryanov, Brindaban C Ranu

Visible-light-mediated reactions have recently emerged as a powerful strategy for the synthesis of diverse organic molecules under mild reaction conditions. Usually, the reactions are performed at room temperature and thus sensitive functional groups remain unaffected. Thus, this protocol has received intense interest from academia as well as industries. The heterocycles, in general, are of much interest because of their biological activities and application in therapeutics. The Oxygen- and Sulfur-containing heterocyclic compounds have recently attracted attention as these compounds showed promising activities as anti-cancer drugs, antibiotics, antifungal and anti-inflammatory agents among other applications. The synthesis of this class of compounds by efficient and greener routes has become an important target. This review highlights the various procedures for the synthesis of these compounds and their derivatives under visible light-induced reactions. The green aspects and mechanism of each procedure have been discussed.

近来,以可见光为媒介的反应已成为在温和的反应条件下合成各种有机分子的有力策略。反应通常在室温下进行,因此敏感的官能团不会受到影响。因此,这种方法受到了学术界和工业界的强烈关注。一般来说,杂环化合物因其生物活性和在治疗学中的应用而备受关注。最近,含氧和含硫杂环化合物引起了人们的关注,因为这些化合物在抗癌药物、抗生素、抗真菌剂和抗炎剂等方面的应用前景广阔。通过高效、绿色的路线合成这类化合物已成为一个重要目标。本综述重点介绍了在可见光诱导反应下合成这类化合物及其衍生物的各种方法。文中还讨论了每种方法的绿色方面和机理。
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引用次数: 0
Molecular Evidence of the Bio-activities of Traditional Home Medicine Ingredients. 传统家庭药材生物活性的分子证据。
IF 2.9 4区 医学 Q3 CHEMISTRY, MEDICINAL Pub Date : 2024-07-02 DOI: 10.2174/0115680266302556240620054134
Jahnvi Hora, Sachin Shetty, Shama Prasada Kabekkodu

For many centuries, traditional medicine has played an essential role in health care. The treatment of many illnesses, including cancer, has greatly benefited from using herbal remedies derived from traditional medicine. The bioactive compounds, such as curcumin, silibinin, berberine, ginseng, and others present in traditional medicine have shown a wide range of properties, such as anti-inflammatory, antimicrobial, anti-oxidant as well as potent anti-cancer properties both in laboratory studies and animal experiments (in vitro and in vivo). In this review, we mainly emphasized the anticancer role of bioactive compounds present in traditional medicine, such as curcumin, cardamonin, piperine, berberine, ginseng, silibinin, epigallocatechin gallate, and asafoetida. We also discussed molecular evidence of these compounds in chemoprevention and anticancer effects. These compounds have the potential to interfere with cancer growth, proliferation, metastasis, and angiogenesis and induce apoptosis by targeting different pathways and the cell cycle. This review article also focuses on how these compounds can help overcome drug resistance and enhance the availability of other clinically approved drugs. The usage of these compounds synergistically with other forms of treatment is also of great fascination to new and upcoming research. Finally, we have discussed the bioavailability of these compounds and strategies employed to improve them so their full potential can be exploited.

几个世纪以来,传统医学在医疗保健中一直发挥着至关重要的作用。许多疾病(包括癌症)的治疗都极大地受益于传统医学中的草药疗法。姜黄素、水飞蓟素、小檗碱、人参等传统医药中的生物活性化合物在实验室研究和动物实验(体外和体内)中显示出多种特性,如抗炎、抗菌、抗氧化以及强效抗癌特性。在这篇综述中,我们主要强调了姜黄素、豆蔻宁、胡椒碱、小檗碱、人参、丝核苷酸、表没食子儿茶素没食子酸酯和阿沙弗他等传统医药中的生物活性化合物的抗癌作用。我们还讨论了这些化合物在化学预防和抗癌作用方面的分子证据。这些化合物有可能干扰癌症的生长、扩散、转移和血管生成,并通过针对不同途径和细胞周期诱导细胞凋亡。这篇综述文章还重点介绍了这些化合物如何帮助克服耐药性并提高其他临床批准药物的可用性。这些化合物与其他治疗方式的协同使用也是即将开展的新研究的一大亮点。最后,我们还讨论了这些化合物的生物利用度,以及为充分挖掘其潜力而采取的改进策略。
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引用次数: 0
Role of Plant Materials with Anti-inflammatory Effects in Phytotherapy of Osteoarthritis. 具有抗炎作用的植物材料在骨关节炎植物疗法中的作用
IF 3.4 4区 医学 Q2 Pharmacology, Toxicology and Pharmaceutics Pub Date : 2024-06-11 DOI: 10.2174/0115680266297662240527105450
Małgorzata Geszke-Moritz, Gerard Nowak, Michał Moritz, Barbara Feist, Jacek E Nycz

Osteoarthritis (OA) is a common chronic articular degenerative disease characterized by articular cartilage degradation, synovial inflammation/immunity, and subchondral bone lesions. Recently, increasing interest has been devoted to treating or preventing OA with herbal medicines. The mechanism of action of plant raw materials used in osteoarthrosis treatment is well documented. They are sought after because of the high frequency of inflammation of the knee joint among both elderly and young people engaged in sports in which their knee joints are often exposed to high-stress conditions. The purpose of this work was to present some most effective and safe plant medicines with proven mechanisms of action that can help to alleviate the growing social problem of osteoarthrosis caused in recent years. A review of the available literature based primarily on the latest editions of ESCOP and EMA monographs and the latest scientific papers has made it possible to select and propose medical management of osteoarthrosis by ranking plant medicines according to their effectiveness. Clinical studies of raw plant materials, such as Harpagophyti radix, Olibanum indicum, and Urticae foliumet herba have indicated that these drugs should be considered the first choice in osteoarthrosis treatment. The efficacy of Rosae pseudo-fructus, Salicis cortex, Filipendulae ulmariae flos et herba, Ribis nigri folium, and externally applied Capsici fructus and Symphyti radix, has also been proven by pharmacological studies. All the plant medicines mentioned in the paper have been studied in detail in terms of their phytochemistry, which can help doctors in their decision-- making in the treatment of osteoarthrosis.

骨关节炎(OA)是一种常见的慢性关节退行性疾病,以关节软骨退化、滑膜炎症/免疫和软骨下骨病变为特征。最近,人们越来越关注用中草药治疗或预防 OA。用于骨关节病治疗的植物原料的作用机理已得到充分证实。由于从事体育运动的老年人和年轻人膝关节经常处于高应力状态下,因此膝关节炎症的发病率很高,植物原料也因此受到追捧。这项工作的目的是介绍一些最有效、最安全的植物药,它们的作用机制已得到证实,有助于缓解近年来日益严重的骨关节病社会问题。主要根据最新版的 ESCOP 和 EMA 专论以及最新的科学论文,对现有文献进行了审查,从而根据植物药的有效性进行排序,选择并提出了骨关节病的医疗管理建议。对 Harpagophyti radix、Olibanum indicum 和 Urticae foliumet herba 等植物原料的临床研究表明,这些药物应被视为骨关节病治疗的首选。Rosae pseudo-fructus、Salicis cortex、Filipendulae ulmariae flos et herba、Ribis nigri folium 以及外敷的 Capsici fructus 和 Symphyti radix 的疗效也已通过药理学研究得到证实。本文提到的所有植物药都经过了详细的植物化学研究,可以帮助医生在治疗骨关节病时做出决策。
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引用次数: 0
A Comprehensive Review on Deep Learning Techniques in Alzheimer's Disease Diagnosis. 深度学习技术在阿尔茨海默病诊断中的应用综述。
IF 3.4 4区 医学 Q2 Pharmacology, Toxicology and Pharmaceutics Pub Date : 2024-06-06 DOI: 10.2174/0115680266310776240524061252
Anjali Mahavar, Atul Patel, Ashish Patel

Alzheimer's Disease (AD) is a serious neurological illness that causes memory loss gradually by destroying brain cells. This deadly brain illness primarily strikes the elderly, impairing their cognitive and bodily abilities until brain shrinkage occurs. Modern techniques are required for an accurate diagnosis of AD. Machine learning has gained attraction in the medical field as a means of determining a person's risk of developing AD in its early stages. One of the most advanced soft computing neural network-based Deep Learning (DL) methodologies has garnered significant interest among researchers in automating early-stage AD diagnosis. Hence, a comprehensive review is necessary to gain insights into DL techniques for the advancement of more effective methods for diagnosing AD. This review explores multiple biomarkers associated with Alzheimer's Disease (AD) and various DL methodologies, including Deep Neural Networks (DNN), Convolutional Neural Networks (CNN), Recurrent Neural Networks (RNN), The k-nearest-neighbor (k-NN), Deep Boltzmann Machines (DBM), and Deep Belief Networks (DBN), which have been employed for automating the early diagnosis of AD. Moreover, the unique contributions of this review include the classification of ATN biomarkers for Alzheimer's Disease (AD), systemic description of diverse DL algorithms for early AD assessment, along with a discussion of widely utilized online datasets such as ADNI, OASIS, etc. Additionally, this review provides perspectives on future trends derived from critical evaluation of each variant of DL techniques across different modalities, dataset sources, AUC values, and accuracies.

阿尔茨海默病(AD)是一种严重的神经系统疾病,通过破坏脑细胞而导致记忆力逐渐减退。这种致命的脑部疾病主要侵袭老年人,损害他们的认知能力和身体机能,直至脑萎缩。准确诊断注意力缺失症需要现代技术。在医学领域,机器学习作为一种在早期阶段确定一个人罹患注意力缺失症风险的手段,已经获得了极大的吸引力。基于深度学习(DL)的最先进的软计算神经网络方法之一,在自动诊断早期注意力缺失症方面引起了研究人员的极大兴趣。因此,有必要进行一次全面的综述,以深入了解深度学习技术,从而开发出更有效的AD诊断方法。本综述探讨了与阿尔茨海默病(AD)相关的多种生物标记物和各种 DL 方法,包括深度神经网络(DNN)、卷积神经网络(CNN)、循环神经网络(RNN)、k-近邻(k-NN)、深度玻尔兹曼机(DBM)和深度信念网络(DBN),这些方法已被用于实现 AD 早期诊断的自动化。此外,本综述的独特贡献还包括对阿尔茨海默病(AD)的ATN生物标记物进行分类,系统描述用于早期AD评估的各种DL算法,以及讨论广泛使用的在线数据集,如ADNI、OASIS等。此外,本综述还通过对不同模式、数据集来源、AUC 值和准确度的每种 DL 技术变体进行批判性评估,对未来趋势提出了展望。
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引用次数: 0
Facile Synthesis and Applications of Flavonoid-Heterocyclic Derivatives. 黄酮类杂环衍生物的简易合成与应用。
IF 3.4 4区 医学 Q2 Pharmacology, Toxicology and Pharmaceutics Pub Date : 2024-06-05 DOI: 10.2174/0115680266303704240524080333
Saba Farooq, Zainab Ngaini

Flavonoids belong to the polyphenol group that naturally exists in fruits, vegetables, tea, and grains. Flavonoids, as secondary metabolites, show indispensable contributions to biolog-ical processes and the responses of plants to numerous environmental factors. The bioactivity of flavonoids depends on C6-C3-C6 ring substitution patterns that exhibit bioactive antioxidant, an-timicrobial, antifungal, antitumor, and anti-inflammatory properties. The synthesis of flavonoids has been reported by various methodologies. Therefore, the present review systematically sum-marizes the synthesis of recent heterocyclic flavonoid derivatives via facile synthetic approaches since the research in flavonoids is useful for therapeutic and biotechnology fields.

类黄酮属于多酚类化合物,天然存在于水果、蔬菜、茶叶和谷物中。类黄酮作为次生代谢产物,对生物化学过程和植物对多种环境因素的反应做出了不可或缺的贡献。类黄酮的生物活性取决于 C6-C3-C6 环的取代模式,它具有抗氧化、抗微生物、抗真菌、抗肿瘤和抗炎等生物活性。黄酮类化合物的合成方法多种多样。因此,本综述系统地总结了近期通过简便合成方法合成杂环类黄酮衍生物的情况,因为类黄酮的研究对治疗和生物技术领域非常有用。
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引用次数: 0
Natural Compounds that Modulate Circadian Rhythms. 调节昼夜节律的天然化合物
IF 3.4 4区 医学 Q2 Pharmacology, Toxicology and Pharmaceutics Pub Date : 2024-05-30 DOI: 10.2174/0115680266300569240514101800
Tatsunosuke Tomita, Renu Wadhwa, Yoshiaki Onishi

Circadian rhythms of innate 24 h cycles comprise well-conserved biological phenomena from cyanobacteria to mammalian. They are driven by light and regulated by clock genes that work as transcription factors and control the expression of many other genes and physiological functions in the cells. The expression of ~ 40% of protein-coding genes shows 24 h oscillation patterns in mice, implying their importance in normal body functions. Indeed, the physiological and behavioural rhythmicity generated through clock genes-mediated multiple mechanisms affects the quality of life at large. Disrupted circadian rhythmicity is associated with several kinds of diseases. For example, cancer cells show abnormal expression patterns for circadian rhythm genes that have been shown to regulate oncogenesis, drug responses, and disease prognosis. Furthermore, the modern globalisation of human lifestyle and business and social activities have disrupted innate circadian rhythm, resulting in a variety of diseases through disrupted humoral, immunological, and neuronal pathways. Safe and sustainable modulation of circadian rhythm has become a prevalent need that warrants basic and interventional research, as well as clinical investigations. Although traditional systems of medicine suggest some natural compounds with circadian rhythmmodulating potential, most of these have not been validated in laboratory or clinical studies. Reliable read-outs of the effects of test compounds on circadian rhythmicity have been limited by the availability of live cell assays. We have, herein, provided an overview of living cell-embedded real- time reporter gene assays designed for screening compounds that modulate circadian rhythm, and discussed the potential of some natural compounds for circadian rhythm modulation as validated by cell-based assay systems, and their role in disease therapeutics.

从蓝藻到哺乳动物,24 小时周期的昼夜节律是保存完好的生物现象。昼夜节律由光驱动,并受时钟基因调节,时钟基因作为转录因子,控制着细胞中许多其他基因的表达和生理功能。在小鼠体内,约 40% 的蛋白质编码基因的表达呈现 24 小时振荡模式,这意味着它们在正常身体功能中的重要性。事实上,通过时钟基因介导的多种机制产生的生理和行为节律性影响着人们的生活质量。昼夜节律紊乱与多种疾病有关。例如,癌细胞显示出昼夜节律基因的异常表达模式,而这些基因已被证明能调节肿瘤发生、药物反应和疾病预后。此外,现代全球化的人类生活方式以及商业和社会活动扰乱了与生俱来的昼夜节律,通过扰乱体液、免疫和神经元通路导致多种疾病。安全、可持续地调节昼夜节律已成为一种普遍需求,需要进行基础和干预研究以及临床调查。尽管传统医学体系认为一些天然化合物具有调节昼夜节律的潜力,但其中大多数尚未在实验室或临床研究中得到验证。由于活细胞检测方法的限制,无法可靠地读出试验化合物对昼夜节律的影响。在此,我们概述了为筛选可调节昼夜节律的化合物而设计的活细胞嵌入式实时报告基因检测方法,并讨论了经细胞检测系统验证的一些天然化合物调节昼夜节律的潜力及其在疾病治疗中的作用。
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引用次数: 0
Revolutionizing Cancer Treatment: Harnessing the Power of Mesenchymal Stem Cells for Precise Targeted Therapy in the Tumor Microenvironment. 革命性的癌症治疗:利用间充质干细胞的力量在肿瘤微环境中进行精确的靶向治疗》(Harnessing the Power of Mesenchymal Stem Cells for Precise Targeted Therapy in the Tumor Microenvironment)。
IF 3.4 4区 医学 Q2 Pharmacology, Toxicology and Pharmaceutics Pub Date : 2024-05-23 DOI: 10.2174/0115680266299112240514103048
Shahram Taeb, Davoud Rostamzadeh, Seyed Mohammad Amini, Mohamad Rahmati, Mostafa Golshekan, Mahmoud Abedinzadeh, Elham Ahmadi, Singh Neha, Masoud Najafi

In recent years, mesenchymal stem cells (MSCs) have emerged as promising anti-- cancer mediators with the potential to treat several cancers. MSCs have been modified to produce anti-proliferative, pro-apoptotic, and anti-angiogenic molecules that could be effective against a variety of malignancies. Additionally, customizing MSCs with cytokines that stimulate pro-tumorigenic immunity or using them as vehicles for traditional chemical molecules with anti-cancer characteristics. Even though the specific function of MSCs in tumors is still challenged, promising outcomes from preclinical investigations of MSC-based gene therapy for a variety of cancers inspire the beginning of clinical trials. In addition, the tumor microenvironment (TME) could have a substantial influence on normal tissue stem cells, which can affect the treatment outcomes. To overcome the complications of TME in cancer development, MSCs could provide some signs of hope for converting TME into unequivocal therapeutic tools. Hence, this review focuses on engineered MSCs (En-MSCs) as a promising approach to overcoming the complications of TME.

近年来,间充质干细胞(MSCs)已成为有望治疗多种癌症的抗癌介质。间充质干细胞经改造后可产生抗增殖、促凋亡和抗血管生成分子,可有效对抗多种恶性肿瘤。此外,利用细胞因子定制间充质干细胞,可刺激促肿瘤免疫,或将间充质干细胞用作具有抗癌特性的传统化学分子的载体。尽管间充质干细胞在肿瘤中的具体功能仍面临挑战,但基于间充质干细胞的基因疗法对多种癌症的临床前研究取得了可喜的成果,这激励着临床试验的开始。此外,肿瘤微环境(TME)会对正常组织干细胞产生重大影响,从而影响治疗效果。为了克服肿瘤微环境在癌症发展中的复杂性,间充质干细胞可为将肿瘤微环境转化为明确的治疗工具提供一些希望。因此,本综述将重点关注工程间充质干细胞(En-MSCs),将其作为克服TME并发症的一种有前途的方法。
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