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Heterocyclic Phytochemicals as Anticancer Agents. 作为抗癌剂的杂环植物化学物质。
IF 2.9 4区 医学 Q3 CHEMISTRY, MEDICINAL Pub Date : 2024-09-27 DOI: 10.2174/0115680266314693240914070250
M Amin Mir, Bimal Krishna Banik

Cancer continues to be a major global health challenge, driving the need for the discovery of novel therapeutic agents. Among these, heterocyclic phytochemicals have gained significant attention for their potential as anticancer agents. This review offers a detailed analysis of various classes of heterocyclic compounds with proven anticancer properties, shedding light on their mechanisms of action. The study draws from a diverse array of natural product sources, detailing the chemical structures and bioactivities of these compounds. Key heterocyclic classes such as alkaloids, flavonoids, coumarins, and terpenoids are emphasized due to their potent anticancer effects. Heterocyclic phytochemicals exhibit diverse anticancer mechanisms, including the modulation of cellular pathways like apoptosis, angiogenesis, and cell cycle progression. The combination of heterocyclic phytochemicals with conventional cancer therapies has shown promising synergistic effects, enhanced treatment efficacy and reducing side effects. The review systematically evaluates both preclinical and clinical studies, revealing the efficacy, safety profiles, and pharmacokinetics of selected heterocyclic compounds. The promising outcomes highlighted in this review underscore the critical need for ongoing research to fully realize the therapeutic potential of heterocyclic phytochemicals in cancer treatment.

癌症仍然是全球健康面临的一大挑战,因此需要发现新型治疗药物。其中,杂环植物化学物质因其作为抗癌剂的潜力而备受关注。这篇综述详细分析了经证实具有抗癌特性的各类杂环化合物,揭示了它们的作用机制。研究从各种天然产品来源中汲取营养,详细介绍了这些化合物的化学结构和生物活性。由于生物碱、类黄酮、香豆素和萜类化合物等主要杂环类化合物具有强大的抗癌作用,因此本研究对它们进行了重点研究。杂环类植物化学物质表现出多种抗癌机制,包括调节细胞凋亡、血管生成和细胞周期进展等细胞通路。杂环植物化学物与传统癌症疗法的结合显示出良好的协同作用,可提高疗效并减少副作用。本综述系统地评估了临床前和临床研究,揭示了某些杂环化合物的疗效、安全性和药代动力学。本综述所强调的良好结果突出表明,要充分发挥杂环植物化学物在癌症治疗中的治疗潜力,亟需进行持续的研究。
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引用次数: 0
Exploring the Therapeutic Potential of Glycyrrhiza Compounds in Alzheimer's Disease: A Comprehensive Review. 探索甘草化合物对阿尔茨海默病的治疗潜力:全面综述。
IF 2.9 4区 医学 Q3 CHEMISTRY, MEDICINAL Pub Date : 2024-09-25 DOI: 10.2174/0115680266322320240911194626
Xiaona Song, Xiaotang Wang, Yao Gao, Guoqiang Xu, Xiaoru Yan, Zhaoyang Chen, Guohua Song

Alzheimer's disease (AD) is a progressive neurodegenerative disorder. Research shows that the development of AD is linked to neuroinflammation, endoplasmic reticulum stress, mitochondrial dysfunction, cell death, and abnormal cholinergic signaling. Glycyrrhiza compounds contain active ingredients and extracts that offer multiple benefits, including targeting various pathways, high efficacy with low toxicity, and long-lasting therapeutic effects. These benefits highlight the significant potential of Glycyrrhiza compounds for preventing and treating AD. This review summarizes recent advancements in Glycyrrhiza compounds for preventing and treating AD. It focuses on their inhibitory effects on key signaling pathways, such as Toll-like receptor 4 (TLR4), nuclear factor-κB (NF-κB), mitogen-activated protein kinase (MAPK), and cholinergic signaling. This study aims to establish a scientific framework for using Glycyrrhiza compounds in the clinical prevention and treatment of AD and to support the development of new therapeutic interventions.

阿尔茨海默病(AD)是一种进行性神经退行性疾病。研究表明,阿尔茨海默病的发生与神经炎症、内质网应激、线粒体功能障碍、细胞死亡和胆碱能信号异常有关。甘草化合物所含的活性成分和提取物具有多种益处,包括针对各种途径、高效低毒、疗效持久等。这些优点凸显了甘草化合物在预防和治疗注意力缺失症方面的巨大潜力。这篇综述总结了甘草化合物在预防和治疗注意力缺失症方面的最新进展。其重点是甘草化合物对关键信号通路的抑制作用,如Toll样受体4(TLR4)、核因子κB(NF-κB)、丝裂原活化蛋白激酶(MAPK)和胆碱能信号传导。这项研究旨在建立一个科学框架,将甘草化合物用于临床预防和治疗注意力缺失症,并支持开发新的治疗干预措施。
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引用次数: 0
The Multitarget Action of Vitamins in the Ischemic Stroke. 维生素在缺血性中风中的多靶点作用
IF 2.9 4区 医学 Q3 CHEMISTRY, MEDICINAL Pub Date : 2024-09-19 DOI: 10.2174/0115680266316939240909070627
Luciana Scotti, Pablo Rayff da Silva, Alex France Messias Monteiro, Rodrigo Santos Aquino de Araújo, Vanessa Lima do Nascimento, Kadja Luana Chagas Monteiro, Thiago Mendonça de Aquino, Wadja Feitosa Dos Santos Silva, Edeildo Ferreira da Silva Junior, Marcus T Scotti, Francisco Jaime Bezerra Mendonça Junior

A stroke, also known as a cerebral hemorrhage, occurs when there is an interruption in the blood supply to a part of the brain, resulting in damage to brain cells. This issue is one of the leading causes of death in developed countries, currently killing about 5 million people annually. Individuals who survive ischemic stroke often face serious vision problems, paralysis, dementia, and other sequelae. The numerous efforts to prevent and/or treat stroke sequelae seem insufficient, which is concerning given the increasing global elderly population and the well-known association between aging and stroke risk. In this review, we aim to present and discuss the importance of vitamins in stroke prevention and/or incidence. Vitamins from diet or dietary supplements influence the body at various levels; they are a relevant factor but are reported only in isolated articles. This review reports and updates the multitarget role of vitamins involved in reducing stroke risk.

中风又称脑出血,是指大脑部分供血中断,导致脑细胞受损。在发达国家,中风是导致死亡的主要原因之一,目前每年约有 500 万人死于中风。缺血性中风的幸存者通常会面临严重的视力问题、瘫痪、痴呆和其他后遗症。预防和/或治疗脑卒中后遗症的努力似乎还不够,鉴于全球老年人口不断增加,且老龄化与脑卒中风险之间存在众所周知的联系,这种情况令人担忧。在本综述中,我们旨在介绍和讨论维生素在中风预防和/或发病中的重要性。饮食或膳食补充剂中的维生素会在不同层面对人体产生影响;它们是一个相关因素,但只在个别文章中有所报道。本综述报告并更新了维生素在降低中风风险中的多靶点作用。
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引用次数: 0
PIM Kinase Inhibitors as Novel Promising Therapeutic Scaffolds in Cancer Therapy. 将 PIM 激酶抑制剂作为癌症治疗的新型治疗支架。
IF 2.9 4区 医学 Q3 CHEMISTRY, MEDICINAL Pub Date : 2024-09-18 DOI: 10.2174/0115680266321659240906114742
Dipanjan Karati, Ankur Saha, Souvik Roy, Swarupananda Mukherjee

Cancer involves the uncontrolled, abnormal growth of cells and affects other tissues. Kinase has an impact on proliferating the cells and causing cancer. For the purpose of treating cancer, PIM kinase is a potential target. The pro-viral Integration site for moloney murine leukaemia virus (PIM) kinases is responsible for the tumorigenesis, by phosphorylating the proteins that control the cell cycle and cell proliferation. PIM-1, PIM-2, and PIM-3 are the three distinct isoforms of PIM kinases. The JAK/STAT pathway is essential for controlling how PIM genes are expressed. PIM kinase is also linked withPI3K/AKT/mTOR pathway in various types of cancers. The overexpression of PIM kinase will cause cancer. Currently, there are significant efforts being made in medication design and development to target its inhibition. A few small chemical inhibitors (E.g., SGI-1776, AZD1208, LGH447) that specifically target the PIM proteins' adenosine triphosphate (ATP)-binding domain have been identified. PIM kinase antagonists have a remarkable effect on different types of cancer. Despite conducting clinical trials on SGI-1776, the first PIM inhibitory agent, was prematurely withdrawn, making it unable to generate concept evidence. On the other hand, in recent years, it has aided in hastening the identification of multiple new PIM inhibitors. Cyanopyridines and Pyrazolo[1,5-a]pyrimidinecan act as potent PIM kinase inhibitors for cancer therapy. We explore the involvement of oncogenic transcription factor c-Mycandmi-RNA in relation to PIM kinase. In this article, we highlight the oncogenic effects, and structural insights into PIM kinase inhibitors for the treatment of cancer.

癌症涉及细胞不受控制的异常生长,并影响其他组织。激酶对细胞增殖和致癌有影响。为了治疗癌症,PIM 激酶是一个潜在的靶点。小鼠白血病病毒(PIM)激酶的亲病毒整合位点通过使控制细胞周期和细胞增殖的蛋白质磷酸化而导致肿瘤发生。PIM-1、PIM-2 和 PIM-3 是 PIM 激酶的三种不同异构体。JAK/STAT 通路对控制 PIM 基因的表达方式至关重要。在各种癌症中,PIM 激酶还与PI3K/AKT/mTOR 通路有关。PIM 激酶的过度表达会导致癌症。目前,针对抑制 PIM 激酶的药物设计和开发正在进行大量工作。目前已发现一些专门针对 PIM 蛋白的三磷酸腺苷(ATP)结合域的小型化学抑制剂(如 SGI-1776、AZD1208 和 LGH447)。PIM 激酶拮抗剂对不同类型的癌症有显著疗效。尽管第一种 PIM 抑制剂 SGI-1776 已进行了临床试验,但由于过早撤回,因此无法产生概念证据。另一方面,近年来,它又加速了多种新的 PIM 抑制剂的发现。氰基吡啶和吡唑并[1,5-a]嘧啶可作为有效的 PIM 激酶抑制剂用于癌症治疗。我们探讨了致癌转录因子 c-Mycandmi-RNA 与 PIM 激酶的关系。在本文中,我们重点介绍了 PIM 激酶的致癌作用,以及治疗癌症的 PIM 激酶抑制剂的结构见解。
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引用次数: 0
From Nature to Drug: Overview and CADD Approach of Anacardic Acid to Propose their Biological Potential. 从自然到药物:概述心绞痛酸并采用 CADD 方法提出其生物潜力。
IF 2.9 4区 医学 Q3 CHEMISTRY, MEDICINAL Pub Date : 2024-09-18 DOI: 10.2174/0115680266319575240905164313
Magna Maria Lima Araújo, Maria Lorena de Oliveira Andrade, Genil Dantas de Oliveira, Igor José Dos Santos Nascimento, Samuel Paulo Cibulski, Harley da Silva Alves

Anacardic acids are natural compounds found in various plant families, such as Anacardiaceae, Geraniaceae, Ginkgoaceae, and Myristicaceae, among others. Several activities have been reported regarding these compounds, including antibacterial, antioxidant, anticancer, anti-inflammatory, and antiviral activities, showing the potential therapeutic applicability of these compounds. From a chemical point of view, they are structurally made up of salicylic acids substituted by an alkyl chain containing unsaturated bonds, which can vary in number and position, determining their bioactivity and differentiating them from the various existing forms. Our work aimed to explore the potential of anacardic acids, based on studies that address the bioactivity of these compounds, as well as to establish a greater understanding of the structure-activity relationship of these compounds through in silico methods, with a focus on the elucidation of a possible drug target through the application of computer-aided drug design, CADD.

无患子酸是一种天然化合物,存在于多种植物科中,如无患子科、鼠李科、银杏科和肉豆蔻科等。据报道,这些化合物具有多种活性,包括抗菌、抗氧化、抗癌、抗炎和抗病毒活性,显示了这些化合物潜在的治疗用途。从化学角度来看,这些化合物在结构上由水杨酸组成,水杨酸被含有不饱和键的烷基链取代,不饱和键的数量和位置各不相同,这就决定了它们的生物活性,并将它们与现有的各种形式区分开来。我们的工作旨在根据对这些化合物生物活性的研究,探索无患子酸的潜力,并通过硅学方法进一步了解这些化合物的结构-活性关系,重点是通过应用计算机辅助药物设计(CADD)阐明可能的药物靶点。
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引用次数: 0
Mentha spicata Mediated Formulation of Iron Oxide Nanoparticles Exhibit Superior Antimicrobial, Antioxidant, and Photodegradation Propensity Compared to Chemically Formulated Counterparts. 薄荷介导的氧化铁纳米粒子配方与化学配方相比具有更强的抗菌、抗氧化和光降解能力。
IF 2.9 4区 医学 Q3 CHEMISTRY, MEDICINAL Pub Date : 2024-09-18 DOI: 10.2174/0115680266332330240910100638
Lipsa Leena Panigrahi, Shashank Shekhar, Ashirdbad Sarangi, Siddharth Satpathy, Ankita Parmanik, Anindya Bose, Debapriya Bhattacharya, Manoranjan Arakha

Introduction: Iron oxide nanoparticles demonstrate tremendous potential in preserving the ecological balance of the environment since they act as antimicrobial agents and efficient photocatalysts. However, environmental sustainability has challenged the synthesis protocols of nanomaterials.

Method: This study compares the green synthesis method with the scalable chemical synthesis method. In this work, Iron oxide nanoparticles were fabricated via the green chemistry technique utilizing the leaf extract of Mentha spicata (M-IONP) and also via the chemical co-precipitation method (C-IONP). The synthesized IONPs were analyzed by different characterization methods such as XRD, FTIR, SEM analysis, ZETA potential measurements, and DLS spectroscopy analysis.

Results: The biosynthesized and chemically synthesized IONPs were analyzed for their mechanistic action against different applications like antimicrobial, antioxidant, and degradation of harmful dyes. Interestingly, the biosynthesized IONPs (M-IONP) exhibited more effective antimicrobial efficacy towards Gram-positive and Gram-negative organisms than chemically synthesized IONPs.

Conclusion: The green synthesized M-IONP also showed significant antioxidant propensity similar to that of the standards taken. Additionally, green-synthesized M-IONP exhibited enhanced degradation efficacies against Methylene blue, chromium, and sulphamethoxazole in comparison to chemically synthesized IONP.

导言:由于氧化铁纳米粒子可用作抗菌剂和高效光催化剂,因此在保护环境生态平衡方面具有巨大潜力。然而,环境的可持续发展对纳米材料的合成方案提出了挑战:本研究比较了绿色合成法和可扩展化学合成法。在这项工作中,利用薄荷叶提取物(M-IONP)和化学共沉淀法(C-IONP),通过绿色化学技术制造了氧化铁纳米粒子。合成的 IONP 通过不同的表征方法进行了分析,如 XRD、FTIR、SEM 分析、ZETA 电位测量和 DLS 光谱分析:结果:对生物合成和化学合成的 IONPs 进行了机理分析,以了解它们在抗菌、抗氧化和降解有害染料等不同应用中的作用。有趣的是,与化学合成的 IONPs 相比,生物合成的 IONPs(M-IONP)对革兰氏阳性和革兰氏阴性菌具有更有效的抗菌功效:结论:绿色合成的 M-IONP 也显示出与所采用的标准相似的显著抗氧化倾向。此外,与化学合成的 IONP 相比,绿色合成的 M-IONP 对亚甲蓝、铬和磺胺甲噁唑的降解效果更好。
{"title":"Mentha spicata Mediated Formulation of Iron Oxide Nanoparticles Exhibit Superior Antimicrobial, Antioxidant, and Photodegradation Propensity Compared to Chemically Formulated Counterparts.","authors":"Lipsa Leena Panigrahi, Shashank Shekhar, Ashirdbad Sarangi, Siddharth Satpathy, Ankita Parmanik, Anindya Bose, Debapriya Bhattacharya, Manoranjan Arakha","doi":"10.2174/0115680266332330240910100638","DOIUrl":"https://doi.org/10.2174/0115680266332330240910100638","url":null,"abstract":"<p><strong>Introduction: </strong>Iron oxide nanoparticles demonstrate tremendous potential in preserving the ecological balance of the environment since they act as antimicrobial agents and efficient photocatalysts. However, environmental sustainability has challenged the synthesis protocols of nanomaterials.</p><p><strong>Method: </strong>This study compares the green synthesis method with the scalable chemical synthesis method. In this work, Iron oxide nanoparticles were fabricated via the green chemistry technique utilizing the leaf extract of Mentha spicata (M-IONP) and also via the chemical co-precipitation method (C-IONP). The synthesized IONPs were analyzed by different characterization methods such as XRD, FTIR, SEM analysis, ZETA potential measurements, and DLS spectroscopy analysis.</p><p><strong>Results: </strong>The biosynthesized and chemically synthesized IONPs were analyzed for their mechanistic action against different applications like antimicrobial, antioxidant, and degradation of harmful dyes. Interestingly, the biosynthesized IONPs (M-IONP) exhibited more effective antimicrobial efficacy towards Gram-positive and Gram-negative organisms than chemically synthesized IONPs.</p><p><strong>Conclusion: </strong>The green synthesized M-IONP also showed significant antioxidant propensity similar to that of the standards taken. Additionally, green-synthesized M-IONP exhibited enhanced degradation efficacies against Methylene blue, chromium, and sulphamethoxazole in comparison to chemically synthesized IONP.</p>","PeriodicalId":11076,"journal":{"name":"Current topics in medicinal chemistry","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142281788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Solar Light-Induced Synthesis of Biologically Active Compounds. 太阳光诱导生物活性化合物的合成。
IF 2.9 4区 医学 Q3 CHEMISTRY, MEDICINAL Pub Date : 2024-09-18 DOI: 10.2174/0115680266318635240906102108
Aparna Das, Devalina Ray, Muhammad Waqar Ashraf, Bimal Krishna Banik

Over the past few years, photocatalytic methods have shown great promise as low-cost, environmentally friendly, and sustainable technologies. During the development of photochemistry, a variety of sources of light were used, including sunlight, compact fluorescent lamps, lasers, and even light-emitting diodes. As a part of preparing diverse organic compounds, the photochemical approach was used, for instance, to form rings, arylated compounds, cycloaddition, functionalized compounds, dehalogenated compounds, oxidized compounds, reduced compounds, isomers, and sensitized compounds. Solar energy is a renewable resource that can be harvested from the sun and this light energy can be changed into chemical energy with the help of photocatalysts. During this green approach, electron-hole pairs are generated in photocatalysts in order to begin reactions by using solar light. It has been highlighted in this article that there have been impressive developments in the use of light, mainly the solar light, to promote important organic reactions, which would otherwise be unattainable under thermal conditions.

在过去几年中,光催化方法作为一种低成本、环保和可持续的技术,已经显示出巨大的前景。在光化学的发展过程中,使用了多种光源,包括太阳光、紧凑型荧光灯、激光,甚至发光二极管。作为制备各种有机化合物的一部分,光化学方法被用于形成环、芳基化化合物、环加成、功能化化合物、脱卤化合物、氧化化合物、还原化合物、异构体和敏化化合物等。太阳能是一种可从太阳获取的可再生资源,在光催化剂的帮助下,这种光能可以转化为化学能。在这种绿色方法中,光催化剂中会产生电子-空穴对,以便利用太阳光开始反应。本文强调,在利用光(主要是太阳光)促进重要的有机反应方面,已经取得了令人瞩目的进展。
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引用次数: 0
Exploring the Therapeutic Potential of Traditional Medicinal Foods in Cancer Treatment: Molecular Evidence and Bioactivities 探索传统药用食品在癌症治疗中的治疗潜力:分子证据和生物活性
IF 3.4 4区 医学 Q3 CHEMISTRY, MEDICINAL Pub Date : 2024-09-10 DOI: 10.2174/0115680266328466240829045659
Kulbhushan Thakur, Tejveer Singh, Deepika Sharma, Nipun Padha, Bilal Ahmad Mir, Atika Chandra, Vijay Rani Rajpal
: Traditional medicinal foods derived from natural sources have gained increasing attention in recent years due to their perceived health benefits and potential therapeutic properties and are deeply rooted in cultural practices. This review aimed at understanding their potential health benefits, emphasizes the need to identify the key bioactive substances in traditional home medicine. We have discussed the bioactive properties, molecular targets, and anti-cancer effects of various compounds such as curcumin, genistein, berberine, resveratrol, and, quercetin present in traditional medicinal foods. Our study highlights the potential of traditional medicinal food in the prevention and management of various health conditions, including cardiovascular diseases, cancer and neurodegenerative disorders as evident from in vitro, in vivo and clinical trials. Additionally, our study explores the mechanistic action of various bioactive constituents of grapes, rosemary, barberry, turmeric and garlic that have been shown to interfere with cancer growth, proliferation, metastasis, angiogenesis, and induce apoptosis by targeting various pathways and the cell cycle. Additionally, a wide range of healing abilities of medicinal foods including their impact on cancer cells demonstrate their direct anti-tumor potential along with antioxidant and antiinflammatory properties. To summarize, the present review highlights that integrating the insights of contemporary science with the age-old wisdom of traditional medicine in a systematic way holds immense potential for developing alternate and effective approaches to cancer therapeutics and offering evidence-based dietary recommendations.
:近年来,从天然资源中提取的传统药用食品越来越受到人们的关注,因为它们具有明显的健康益处和潜在的治疗特性,并深深植根于文化习俗之中。本综述旨在了解其潜在的健康益处,强调有必要确定传统家庭药膳中的关键生物活性物质。我们讨论了传统药膳中姜黄素、染料木素、小檗碱、白藜芦醇和槲皮素等多种化合物的生物活性特性、分子靶点和抗癌作用。我们的研究强调了传统药用食品在预防和治疗心血管疾病、癌症和神经退行性疾病等各种健康状况方面的潜力,这一点在体外、体内和临床试验中都得到了证实。此外,我们的研究还探讨了葡萄、迷迭香、巴比妥、姜黄和大蒜中各种生物活性成分的作用机理,这些成分已被证明可以通过靶向各种途径和细胞周期,干扰癌症的生长、增殖、转移、血管生成并诱导细胞凋亡。此外,药用食品具有广泛的治疗能力,包括对癌细胞的影响,这表明它们具有直接抗肿瘤的潜力以及抗氧化和抗炎特性。总之,本综述强调,以系统的方式将当代科学的见解与传统医学的古老智慧相结合,在开发替代性有效癌症治疗方法和提供循证膳食建议方面具有巨大潜力。
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引用次数: 0
Identification and Verification of a Prognostic Risk Signature in Oral Squamous Cell Carcinoma. 口腔鳞状细胞癌预后风险特征的识别与验证
IF 2.9 4区 医学 Q3 CHEMISTRY, MEDICINAL Pub Date : 2024-09-05 DOI: 10.2174/0115680266335055240828061128
Rishou Chen, Junlin Duan, Yonglong Ye, Huan Xu, Yali Ding, Jun Liu

Introduction: Oral squamous cell carcinoma (OSCC) is a prevalent malignant condition. This study aimed to investigate the role of mTORC1 signaling and develop a prognostic model for OSCC.

Materials and methods: The single-sample gene set enrichment analysis (ssGSEA) algorithm was utilized to calculate the Z-Score of Hallmarks in OSCC, followed by univariate Cox regression analysis to identify processes associated with prognosis. Weighted gene co-expression network analysis (WGCNA) was performed using transcriptomic data from the cancer genome atlas (TCGA) cohort to identify genes correlated with mTORC1 signaling. A six-gene prognostic model was constructed using multifactorial Cox regression analysis and validated using an external dataset.

Results: The study uncovered a strong linkage between mTORC1, glycolysis, hypoxia, and the prognosis of OSCC. mTORC1 signaling emerged as the most significant risk factor, negatively impacting patient survival. Additionally, a six-gene prognostic risk score model was developed which provided a quantitative measure of patients' survival probabilities. Interestingly, within the context of these findings, TP53 gene mutations were predominantly observed in the high-risk group, potentially underlining the genetic complexity of this patient subgroup. Additionally, differential immune cell infiltration and an integrated nomogram were also reported.

Conclusion: This study highlights the importance of mTORC1 signaling in OSCC prognosis and presents a robust prognostic model for predicting patient outcomes.

简介口腔鳞状细胞癌(OSCC)是一种常见的恶性肿瘤。本研究旨在探讨mTORC1信号转导的作用,并建立OSCC的预后模型:利用单样本基因组富集分析(ssGSEA)算法计算OSCC标志物的Z-Score,然后进行单变量Cox回归分析,以确定与预后相关的过程。利用癌症基因组图谱(TCGA)队列中的转录组数据进行了加权基因共表达网络分析(WGCNA),以确定与mTORC1信号转导相关的基因。利用多因素考克斯回归分析构建了一个六基因预后模型,并利用外部数据集进行了验证:研究发现,mTORC1、糖酵解、缺氧与 OSCC 的预后之间存在密切联系。此外,研究人员还建立了一个六基因预后风险评分模型,对患者的生存概率进行量化测量。有趣的是,在这些研究结果中,TP53 基因突变主要出现在高危人群中,这可能凸显了这一患者亚群的遗传复杂性。此外,还报告了不同的免疫细胞浸润和综合提名图:本研究强调了mTORC1信号在OSCC预后中的重要性,并提出了一个预测患者预后的可靠模型。
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引用次数: 0
A Method for Predicting Allelic Variants of Single Nucleotide Polymorphisms. 预测单核苷酸多态性等位基因变异的方法。
IF 2.9 4区 医学 Q3 CHEMISTRY, MEDICINAL Pub Date : 2024-09-05 DOI: 10.2174/0115680266328330240828040922
Ekaterina Evgenyevna Tyagunova, Alexander Sergeevich Zakharov, Galina Valerievna Pavlova, Daria Alexandrovna Ogarkova, Natalia Alexandrovna Zhuchenko, Vladimir Alexeyevich Gushchin

Introduction: Single nucleotide polymorphisms (SNPs) are pivotal in clinical genetics, serving to link genotypes with disease susceptibility and response to environmental factors, including pharmacogenetics. They also play a crucial role in population genetics for mapping the human genome and localizing genes. Despite their utility, challenges arise when molecular genetic studies yield insufficient or uninformative data, particularly for socially significant diseases. This study aims to address these gaps by proposing a method to predict allelic variants of SNPs.

Method: Using quantitative PCR and analyzing body composition data from 150 patients with their voluntary informed consent, we employed IBM SPSS Statistics 29.0 for data analysis. Our prototype formula, exemplified by allelic variant ADRB2 (rs1042713) = 0.257 + 0.639 * allelic variant ADRB2 (rs1042714) - 0.314 * allelic variant ADRB3 (rs4994) + 0.191 * allelic variant PPARA (rs4253778) - 0.218 * allelic variant PPARD (rs2016520) + 0.027 * body weight + 0.00001 * body weight², demonstrates the feasibility of predicting SNP allelic variants.

Results: This method holds promise for diverse diseases, including those of significant social impact, due to its potential to streamline and economize molecular genetic research. Its ability to stratify disease risk in the absence of complete SNP data makes it particularly compelling for clinical and laboratory geneticists.

Conclusion: However, its translation into clinical practice necessitates the establishment of a comprehensive SNP database, especially for frequently analyzed SNPs within the implementing institution.

导言:单核苷酸多态性(SNPs)在临床遗传学中举足轻重,可将基因型与疾病易感性和对环境因素的反应联系起来,包括药物遗传学。在群体遗传学中,SNP 在绘制人类基因组图谱和定位基因方面也发挥着至关重要的作用。尽管分子遗传学很有用,但当分子遗传学研究产生的数据不足或信息不充分时,尤其是对社会重大疾病而言,就会出现挑战。本研究旨在通过提出一种预测 SNPs 等位基因变异的方法来弥补这些不足:方法:我们使用定量 PCR 分析了 150 名患者的身体成分数据,并获得了他们的自愿知情同意。我们的原型公式为等位基因变异 ADRB2 (rs1042713) = 0.257 + 0.639 * 等位基因变异 ADRB2 (rs1042714) - 0.314 * 等位基因变异 ADRB3 (rs4994) + 0.191 * 等位基因变异体 PPARA (rs4253778) - 0.218 * 等位基因变异体 PPARD (rs2016520) + 0.027 * 体重 + 0.00001 * 体重²,证明了预测 SNP 等位基因变异体的可行性:结果:由于这种方法具有简化和节约分子遗传研究的潜力,因此有望用于各种疾病,包括对社会有重大影响的疾病。它能在缺乏完整 SNP 数据的情况下对疾病风险进行分层,这对临床和实验室遗传学家来说尤其具有吸引力:然而,要将其应用到临床实践中,就必须建立一个全面的 SNP 数据库,尤其是针对实施机构内经常分析的 SNP。
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引用次数: 0
期刊
Current topics in medicinal chemistry
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