The connection between the heart and great vessels established during embryogenesis is essential for circulation. However, how great veins adhere to the endocardium lining the inside lumen of the beating heart remains unknown. Here, using zebrafish, we demonstrate that the endocardium and great veins are sealed in a zipper-closing manner outside the beating heart. The gradual elongation of the endocardium, driven by convergent extension, organized this adhesion by pulling venous endothelial cells (ECs) along the anterior-posterior axis. Time-specific manipulation of the heart rate revealed that this endocardial elongation proceeds against heartbeat-driven force. From time-lapse imaging of adherens junctions, which would counterbalance mechanical forces, we found a specific contribution of cadherin-6 instead of cadherin-5 in sensing endocardium-specific mechanical force. This specificity was confirmed by the depletion of cadherin-6 that caused endocardium deformation. Altogether, we propose that cadherin-6-mediated EC-zippering updates the understanding of cadherin usage in dynamic morphogenesis.
{"title":"Endothelial-zippering proceeds by sensing heartbeat-driven force through cadherin-6 during heart-vessel connection in zebrafish","authors":"Moe Fukumoto, Haruko Watanabe-Takano, Hajime Fukui, Ayano Chiba, Keisuke Sako, Hiroyuki Nakajima, Naoki Mochizuki","doi":"10.1016/j.devcel.2025.10.011","DOIUrl":"https://doi.org/10.1016/j.devcel.2025.10.011","url":null,"abstract":"The connection between the heart and great vessels established during embryogenesis is essential for circulation. However, how great veins adhere to the endocardium lining the inside lumen of the beating heart remains unknown. Here, using zebrafish, we demonstrate that the endocardium and great veins are sealed in a zipper-closing manner outside the beating heart. The gradual elongation of the endocardium, driven by convergent extension, organized this adhesion by pulling venous endothelial cells (ECs) along the anterior-posterior axis. Time-specific manipulation of the heart rate revealed that this endocardial elongation proceeds against heartbeat-driven force. From time-lapse imaging of adherens junctions, which would counterbalance mechanical forces, we found a specific contribution of cadherin-6 instead of cadherin-5 in sensing endocardium-specific mechanical force. This specificity was confirmed by the depletion of cadherin-6 that caused endocardium deformation. Altogether, we propose that cadherin-6-mediated EC-zippering updates the understanding of cadherin usage in dynamic morphogenesis.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":"14 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145485827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-11DOI: 10.1016/j.devcel.2025.10.012
Agata Burian, Andrzej Kokosza, Magdalena Raczyńska-Szajgin, Pavel Solansky, Marja C.P. Timmermans, Wojciech Palubicki
In plants, the development of the shoot vascular system is closely coordinated with lateral organ formation at the shoot apical meristem. Despite extensive studies on leaf initiation and vascular patterning, it remains unclear how vascular development relates to organogenesis. Current hypotheses emphasize PIN1-mediated polar auxin transport from the meristem surface in initiating and integrating new vascular strands into the existing vasculature. Using high-resolution 3D imaging of auxin reporters and genetic analysis, we show that vascular strands form within the vascular cylinder independently of surface-derived auxin, yet their organization reflects the phyllotactic pattern of leaf primordia. To resolve this paradox, we developed a computational model based on repulsive interactions between strands, which reproduces the dynamic spatial arrangement of strands observed in planta. Our findings reveal a biphasic development of the shoot vascular system, governed by self-organizing principles that determine its patterning.
{"title":"Self-organization of vascular strands drives their patterning in the Arabidopsis shoot apex","authors":"Agata Burian, Andrzej Kokosza, Magdalena Raczyńska-Szajgin, Pavel Solansky, Marja C.P. Timmermans, Wojciech Palubicki","doi":"10.1016/j.devcel.2025.10.012","DOIUrl":"https://doi.org/10.1016/j.devcel.2025.10.012","url":null,"abstract":"In plants, the development of the shoot vascular system is closely coordinated with lateral organ formation at the shoot apical meristem. Despite extensive studies on leaf initiation and vascular patterning, it remains unclear how vascular development relates to organogenesis. Current hypotheses emphasize PIN1-mediated polar auxin transport from the meristem surface in initiating and integrating new vascular strands into the existing vasculature. Using high-resolution 3D imaging of auxin reporters and genetic analysis, we show that vascular strands form within the vascular cylinder independently of surface-derived auxin, yet their organization reflects the phyllotactic pattern of leaf primordia. To resolve this paradox, we developed a computational model based on repulsive interactions between strands, which reproduces the dynamic spatial arrangement of strands observed <em>in planta</em>. Our findings reveal a biphasic development of the shoot vascular system, governed by self-organizing principles that determine its patterning.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":"47 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145485832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The transition from vegetative to reproductive growth is vital for plant fitness and crop yield and is strongly influenced by nutrient availability. While nitrogen deficiency accelerates flowering, phosphorus (P) limitation delays it. However, the molecular basis for how P availability regulates flowering time remains unclear. Here, through genome-wide association mapping in Arabidopsis, we uncover genetic variation in β-GLUCOSIDASE 25 (bGLU25) that modulates flowering under P-limited conditions. In P-sufficient environments, bGLU25 localizes to the endoplasmic reticulum. Under P limitation, however, bGLU25 translocates to the cytosol, a process mediated by P-regulated SERINE CARBOXY PEPTIDASE-Like 50 (SCPL50). In the cytosol, bGLU25 binds to JACALIN-LECTIN LIKE1 (AtJAC1), preventing the nuclear translocation of the Flowering Locus C (FLC) regulator GLYCINE-RICH RNA-BINDING PROTEIN 7 (GRP7). Cytosolic sequestration of GRP7 during P deprivation elevates FLC expression, contributing to delayed flowering. Our findings provide a molecular framework for breeding strategies to optimize flowering time in response to P levels.
从营养生长到生殖生长的转变对植物适应性和作物产量至关重要，并受到养分有效性的强烈影响。缺氮加速开花，缺磷延缓开花。然而，磷有效性调控开花时间的分子基础尚不清楚。在这里，通过拟南芥全基因组关联图谱，我们揭示了β-葡萄糖苷酶25 （bGLU25）在p限制条件下调节开花的遗传变异。在p充足的环境中，bGLU25定位于内质网。然而，在P限制下，bGLU25易位到细胞质中，这是一个由P调节的丝氨酸羧基肽酶样50 （SCPL50）介导的过程。在细胞质中，bGLU25与jacin -凝集素LIKE1 （AtJAC1）结合，阻止开花位点C （FLC）调节因子GLYCINE-RICH RNA-BINDING PROTEIN 7 （GRP7）的核易位。在缺磷过程中，细胞质中GRP7的隔离会提高FLC的表达，导致开花延迟。我们的研究结果为优化开花时间响应磷水平的育种策略提供了一个分子框架。
{"title":"Phosphorus availability controls flowering time through subcellular reprogramming of bGLU25 and GRP7 in Arabidopsis","authors":"Huikyong Cho, Ilyeong Choi, Nadia Bouain, Amjad Nawaz, Luqing Zheng, Zaigham Shahzad, Federica Brandizzi, Seung Y. Rhee, Hatem Rouached","doi":"10.1016/j.devcel.2025.10.005","DOIUrl":"https://doi.org/10.1016/j.devcel.2025.10.005","url":null,"abstract":"The transition from vegetative to reproductive growth is vital for plant fitness and crop yield and is strongly influenced by nutrient availability. While nitrogen deficiency accelerates flowering, phosphorus (P) limitation delays it. However, the molecular basis for how P availability regulates flowering time remains unclear. Here, through genome-wide association mapping in <em>Arabidopsis</em>, we uncover genetic variation in <em>β-GLUCOSIDASE 25</em> (<em>bGLU25</em>) that modulates flowering under P-limited conditions. In P-sufficient environments, bGLU25 localizes to the endoplasmic reticulum. Under P limitation, however, bGLU25 translocates to the cytosol, a process mediated by P-regulated SERINE CARBOXY PEPTIDASE-Like 50 (SCPL50). In the cytosol, bGLU25 binds to JACALIN-LECTIN LIKE1 (AtJAC1), preventing the nuclear translocation of the <em>Flowering Locus C</em> (<em>FLC</em>) regulator GLYCINE-RICH RNA-BINDING PROTEIN 7 (GRP7). Cytosolic sequestration of GRP7 during P deprivation elevates <em>FLC</em> expression, contributing to delayed flowering. Our findings provide a molecular framework for breeding strategies to optimize flowering time in response to P levels.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":"13 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145434669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-04DOI: 10.1016/j.devcel.2025.10.007
Lydie Couturier, Juan Luna-Escalante, Khallil Mazouni, Claire Mestdagh, Minh-Son Phan, Jean-Yves Tinevez, François Schweisguth, Francis Corson
Pattern formation in developing tissues often involves self-organization guided by positional information. In most tissues, however, its dynamics, and therefore the underlying logic, remain unknown. Examining self-organized patterning of the fly eye, we combine experiments and modeling to elucidate how rows of light-receiving units emerge in the wake of a traveling differentiation front to form a crystal-like array. Live imaging of the proneural factor Atonal reveals unanticipated oscillations at the front, which are produced by the successive activation of two distinct enhancers and associated with pulsatile Notch signaling. Our observations are inconsistent with current models of eye patterning, whereby each row of differentiating cells provides a negative template for the next. Instead, they inform a relay model in which transient Notch signaling from differentiating cells provides a positive template for the onset of differentiation two rows ahead, conveying both temporal and spatial information to propagate oscillations and crystal-like order.
{"title":"Pulsatile dynamics propagate crystalline order in the developing Drosophila eye","authors":"Lydie Couturier, Juan Luna-Escalante, Khallil Mazouni, Claire Mestdagh, Minh-Son Phan, Jean-Yves Tinevez, François Schweisguth, Francis Corson","doi":"10.1016/j.devcel.2025.10.007","DOIUrl":"https://doi.org/10.1016/j.devcel.2025.10.007","url":null,"abstract":"Pattern formation in developing tissues often involves self-organization guided by positional information. In most tissues, however, its dynamics, and therefore the underlying logic, remain unknown. Examining self-organized patterning of the fly eye, we combine experiments and modeling to elucidate how rows of light-receiving units emerge in the wake of a traveling differentiation front to form a crystal-like array. Live imaging of the proneural factor Atonal reveals unanticipated oscillations at the front, which are produced by the successive activation of two distinct enhancers and associated with pulsatile Notch signaling. Our observations are inconsistent with current models of eye patterning, whereby each row of differentiating cells provides a negative template for the next. Instead, they inform a relay model in which transient Notch signaling from differentiating cells provides a positive template for the onset of differentiation two rows ahead, conveying both temporal and spatial information to propagate oscillations and crystal-like order.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":"13 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145434671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-04DOI: 10.1016/j.devcel.2025.10.006
Iván Company-Garrido, Alberto Zurita Carpio, Mariona Colomer-Rosell, Bernard Ciraulo, Ronja Molkenbur, Peter Lanzerstorfer, Fabio Pezzano, Costanza Agazzi, Robert Hauschild, Saumey Jain, Jeroen M. Jacques, Valeria Venturini, Christian Knapp, Yufei Xie, Jack Merrin, Julian Weghuber, Marcel Schaaf, Romain Quidant, Eva Kiermaier, Jaime Ortega Arroyo, Stefan Wieser
Effective immune responses rely on the efficient migration of leukocytes. Yet, how temperature regulates migration dynamics at the single-cell level has remained poorly understood. Using zebrafish embryos and mouse tissue explants, we found that temperature positively regulates leukocyte migration speed, exploration, and arrival frequencies to wounds and lymph vessels. Complementary 2D and 3D cultures revealed that this thermokinetic control of cell migration is conserved across immune cell types, independently of the 3D tissue environment. By applying precise (sub-)cellular temperature modulation, we identified a rapid and reversible thermo-response that depends on myosin II activity. Small physiological increases in temperature (1°C –2°C), as present during fever-like conditions, profoundly increased immune responses by accelerating arrival times at lymphatic vessels and tissue wounds. These findings identify myosin-II-dependent actomyosin contractility as a critical mechanical structure regulating single-cell thermo-adaptability, with physiological implications for tuning the speed of immune responses in vivo.
{"title":"Myosin II regulates cellular thermo-adaptability and the efficiency of immune responses","authors":"Iván Company-Garrido, Alberto Zurita Carpio, Mariona Colomer-Rosell, Bernard Ciraulo, Ronja Molkenbur, Peter Lanzerstorfer, Fabio Pezzano, Costanza Agazzi, Robert Hauschild, Saumey Jain, Jeroen M. Jacques, Valeria Venturini, Christian Knapp, Yufei Xie, Jack Merrin, Julian Weghuber, Marcel Schaaf, Romain Quidant, Eva Kiermaier, Jaime Ortega Arroyo, Stefan Wieser","doi":"10.1016/j.devcel.2025.10.006","DOIUrl":"https://doi.org/10.1016/j.devcel.2025.10.006","url":null,"abstract":"Effective immune responses rely on the efficient migration of leukocytes. Yet, how temperature regulates migration dynamics at the single-cell level has remained poorly understood. Using zebrafish embryos and mouse tissue explants, we found that temperature positively regulates leukocyte migration speed, exploration, and arrival frequencies to wounds and lymph vessels. Complementary 2D and 3D cultures revealed that this thermokinetic control of cell migration is conserved across immune cell types, independently of the 3D tissue environment. By applying precise (sub-)cellular temperature modulation, we identified a rapid and reversible thermo-response that depends on myosin II activity. Small physiological increases in temperature (1°C –2°C), as present during fever-like conditions, profoundly increased immune responses by accelerating arrival times at lymphatic vessels and tissue wounds. These findings identify myosin-II-dependent actomyosin contractility as a critical mechanical structure regulating single-cell thermo-adaptability, with physiological implications for tuning the speed of immune responses <em>in vivo.</em>","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":"28 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145434687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-03DOI: 10.1016/j.devcel.2025.09.019
Hallvard L. Olsvik, Terje Johansen
Selective autophagy is important for organelle quality control. In this issue of Developmental Cell, Yang et al. identify the Golgi resident transmembrane protein TM9SF3 as a selective autophagy receptor required for lysosomal degradation of Golgi fragments (Golgiphagy) following nutrient stress, pH disruption, blockade of ER-to-Golgi trafficking, and defects in Golgi-mediated glycosylation functions.
{"title":"Golgiphagy mediated by TM9SF3 acts as quality control for stressed Golgi","authors":"Hallvard L. Olsvik, Terje Johansen","doi":"10.1016/j.devcel.2025.09.019","DOIUrl":"https://doi.org/10.1016/j.devcel.2025.09.019","url":null,"abstract":"Selective autophagy is important for organelle quality control. In this issue of <em>Developmental Cell</em>, Yang et al. identify the Golgi resident transmembrane protein TM9SF3 as a selective autophagy receptor required for lysosomal degradation of Golgi fragments (Golgiphagy) following nutrient stress, pH disruption, blockade of ER-to-Golgi trafficking, and defects in Golgi-mediated glycosylation functions.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":"28 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145427919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-03DOI: 10.1016/j.devcel.2025.09.020
Jay W. Zussman, Diana J. Laird
In this issue of Developmental Cell, Nosaka et al. differentiate mouse pluripotent stem cells to large germinal vesicle-stage oocyte-like cells in the absence of ovarian somatic cells. Their paradigm advances the field toward clinical translation and offers insights into oogonial cyst breakdown, X chromosome dynamics, and requirements for oocyte growth and meiotic resumption.
{"title":"In vitro oogenesis breaks free of the ovary","authors":"Jay W. Zussman, Diana J. Laird","doi":"10.1016/j.devcel.2025.09.020","DOIUrl":"https://doi.org/10.1016/j.devcel.2025.09.020","url":null,"abstract":"In this issue of <em>Developmental Cell</em>, Nosaka et al. differentiate mouse pluripotent stem cells to large germinal vesicle-stage oocyte-like cells in the absence of ovarian somatic cells. Their paradigm advances the field toward clinical translation and offers insights into oogonial cyst breakdown, X chromosome dynamics, and requirements for oocyte growth and meiotic resumption.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":"55 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145427921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-03DOI: 10.1016/j.devcel.2025.10.010
Francis Y. He, Adrienne Boire
In this issue of Developmental Cell, Nör et al. show that radiation induces inflammation in medulloblastoma (MB), disrupting the blood-brain barrier and promoting leptomeningeal metastasis. They show that systemic inflammation alone can drive dissemination, and ameliorating inflammation reduces metastatic burden, highlighting the paradoxical role of immune responses in CNS tumors.
{"title":"Inflammation accelerates metastasis: Medulloblastoma leptomeningeal dissemination","authors":"Francis Y. He, Adrienne Boire","doi":"10.1016/j.devcel.2025.10.010","DOIUrl":"https://doi.org/10.1016/j.devcel.2025.10.010","url":null,"abstract":"In this issue of <em>Developmental Cell</em>, Nör et al. show that radiation induces inflammation in medulloblastoma (MB), disrupting the blood-brain barrier and promoting leptomeningeal metastasis. They show that systemic inflammation alone can drive dissemination, and ameliorating inflammation reduces metastatic burden, highlighting the paradoxical role of immune responses in CNS tumors.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":"22 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145427930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-03DOI: 10.1016/j.devcel.2025.10.004
Xinyan Qin, Tianze Yu, Yan Yan, Hong Li, Siyu Hou, Zhi Zhou, Zehui Tang, Jie Duan, Jing Peng, Run Han, Meijiao Wang, Ziyi Feng, Wei Cao, William Terzaghi, Yingyin Yao, Shuhua Yang, Zhizhong Gong, Hongtao Liu, Jigang Li
Light signal plays a profound role in modulating plant growth and development. Currently, it remains obscure whether certain light signaling components can alter their roles according to the light quality. Here, we show that three sucrose non-fermenting 1 (SNF1)-related protein kinase 2 (SnRK2) family members in Arabidopsis, SnRK2.2/3/6, exert dual effects on hypocotyl elongation under far-red (FR) and red (R) light. SnRK2s interact with ELONGATED HYPOCOTYL5 (HY5) and PHYTOCHROME-INTERACTING FACTOR4 (PIF4), two key factors that antagonistically regulate hypocotyl elongation, and promote the abundance of both proteins in the light. Notably, the opposite effects of SnRK2s in FR and R light are attributed to different functional significance of HY5 and PIF4. Furthermore, SnRK2s promote the accumulation of HY5 and PIF4, possibly by regulating their interactions with CONSTITUTIVELY PHOTOMORPHOGENIC1. Together, our study uncovers the role of SnRK2s in photomorphogenesis, allowing plants to adjust their growth strategy according to their dynamic light conditions.
{"title":"Light-quality-directed plant growth strategy controlled by SnRK2s","authors":"Xinyan Qin, Tianze Yu, Yan Yan, Hong Li, Siyu Hou, Zhi Zhou, Zehui Tang, Jie Duan, Jing Peng, Run Han, Meijiao Wang, Ziyi Feng, Wei Cao, William Terzaghi, Yingyin Yao, Shuhua Yang, Zhizhong Gong, Hongtao Liu, Jigang Li","doi":"10.1016/j.devcel.2025.10.004","DOIUrl":"https://doi.org/10.1016/j.devcel.2025.10.004","url":null,"abstract":"Light signal plays a profound role in modulating plant growth and development. Currently, it remains obscure whether certain light signaling components can alter their roles according to the light quality. Here, we show that three sucrose non-fermenting 1 (SNF1)-related protein kinase 2 (SnRK2) family members in <em>Arabidopsis</em>, SnRK2.2/3/6, exert dual effects on hypocotyl elongation under far-red (FR) and red (R) light. SnRK2s interact with ELONGATED HYPOCOTYL5 (HY5) and PHYTOCHROME-INTERACTING FACTOR4 (PIF4), two key factors that antagonistically regulate hypocotyl elongation, and promote the abundance of both proteins in the light. Notably, the opposite effects of SnRK2s in FR and R light are attributed to different functional significance of HY5 and PIF4. Furthermore, SnRK2s promote the accumulation of HY5 and PIF4, possibly by regulating their interactions with CONSTITUTIVELY PHOTOMORPHOGENIC1. Together, our study uncovers the role of SnRK2s in photomorphogenesis, allowing plants to adjust their growth strategy according to their dynamic light conditions.","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":"53 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145427918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-30DOI: 10.1016/j.devcel.2025.10.002
Allyson Caldwell, Liheng Yang, Elizabeth A. Scheef, Amitinder Kaur, Carolyn B. Coyne
{"title":"Comparative analysis of rhesus macaque and human placental organoids highlights evolutionary differences in placentation","authors":"Allyson Caldwell, Liheng Yang, Elizabeth A. Scheef, Amitinder Kaur, Carolyn B. Coyne","doi":"10.1016/j.devcel.2025.10.002","DOIUrl":"https://doi.org/10.1016/j.devcel.2025.10.002","url":null,"abstract":"","PeriodicalId":11157,"journal":{"name":"Developmental cell","volume":"8 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145396748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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