Developmental cell最新文献

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A matter of selectivity: ER-phagy suppression at the onset of pancreatic cancer. 选择性问题：胰腺癌发病时er吞噬抑制。

IF 8.7 1区生物学 Q1 CELL BIOLOGY

Developmental cell

Pub Date : 2025-12-15 DOI: 10.1016/j.devcel.2025.11.005

Carmine Settembre

KRAS mutations drive pancreatic ductal adenocarcinoma (PDAC). In this issue of Developmental Cell, Salomó Coll et al.¹ reveal that KRAS suppresses endoplasmic reticulum (ER)-phagy in pancreatic acinar cells by inhibiting CCPG1 transcription. Impaired ER-phagy triggers protein aggregation, inflammation, and acinar-to-ductal metaplasia, promoting tumorigenesis. These findings highlight selective autophagy's role in cancer, with possible therapeutic implications.

KRAS突变驱动胰腺导管腺癌（PDAC）。在这一期的Developmental Cell中，Salomó Coll等人1发现KRAS通过抑制CCPG1转录抑制胰腺腺泡细胞的内质网（ER）吞噬。受损的er吞噬触发蛋白质聚集、炎症和腺泡到导管的化生，促进肿瘤发生。这些发现强调了选择性自噬在癌症中的作用，可能具有治疗意义。

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Primary cilia as architects of the neocortex: Roles in brain development, function, and microcephaly 初级纤毛作为新皮质的建筑师：在大脑发育、功能和小头畸形中的作用

IF 11.8 1区生物学 Q1 CELL BIOLOGY

Developmental cell

Pub Date : 2025-12-04 DOI: 10.1016/j.devcel.2025.11.002

Oskar Kaaber Thomsen, Jindřiška Leischner Fialová, Canan Doganli, Cristian Herrera-Cid, Kjeld Møllgård, Alexandre Benmerah, Lars Allan Larsen, Søren Tvorup Christensen

The etiology of primary hereditary microcephaly (MCPH), a condition closely linked to neocortex development, remains poorly understood. Initially, MCPH genes were thought to regulate a limited set of cellular processes, but recent studies reveal that many encode multifunctional proteins, often converging on primary cilia, organelles that orchestrate the development of most vertebrate tissues and organs. In this perspective article, we examine the role of primary cilia in brain development and explore how disruptions in MCPH and microcephaly-associated proteins compromise ciliary dynamics and function. We highlight additional cilia-related proteins with potential influence on neurodevelopment. By elucidating the connections between primary cilia and neural development, we aim to provide insights into mechanisms of neuroregeneration. Ultimately, advancing our understanding of primary cilia may help develop therapeutic strategies to restore neuronal function and improve outcomes for individuals with neurodevelopmental disorders.

原发性遗传性小头畸形（MCPH）是一种与新皮质发育密切相关的疾病，其病因尚不清楚。最初，MCPH基因被认为调节有限的细胞过程，但最近的研究表明，许多基因编码多功能蛋白质，通常聚集在初级纤毛上，这是协调大多数脊椎动物组织和器官发育的细胞器。在这篇前瞻性文章中，我们研究了初级纤毛在大脑发育中的作用，并探讨了MCPH和小头症相关蛋白的破坏如何损害纤毛的动力学和功能。我们强调了对神经发育有潜在影响的其他纤毛相关蛋白。通过阐明初级纤毛与神经发育之间的联系，我们旨在为神经再生的机制提供见解。最终，推进我们对初级纤毛的理解可能有助于制定治疗策略，以恢复神经功能并改善神经发育障碍患者的预后。

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引用次数: 0

Dual role of Oct4 and Sox2 in controlling the developmental capacity and timing of tissue morphogenesis in the embryonic lineage Oct4和Sox2在胚胎谱系中控制发育能力和组织形态发生时间的双重作用

IF 11.8 1区生物学 Q1 CELL BIOLOGY

Developmental cell

Pub Date : 2025-12-02 DOI: 10.1016/j.devcel.2025.11.003

Deepthi Chandramohan, Rongge Yan, Kai Kruse, Heike Brinkmann, Hyun-Woo Jeong, Yanlin Hou, Kenjiro Adachi, Hans R. Schöler, Ivan Bedzhov

The fundamental processes of cell fate specification, differentiation, and morphogenesis must be finely synchronized to enable proper developmental progression, yet the molecular factors coordinating these processes are not well understood. A key driver of embryonic morphogenesis is the establishment of epithelial polarity, which organizes and structures the early cell layers. Here, we investigated factors controlling the epithelialization in epiblast cells and implemented sequential loss-of-function approaches in mouse embryos to define the timing of developmental significance. We found that the expression wave of the core pluripotency factors Oct4 and Sox2 following the 8-cell stage plays a critical role in this process. In this context, one of the key shared functions of these factors is to prevent premature activation of the epithelial program until the completion of the second lineage segregation. Thus, Oct4 and Sox2 simultaneously govern developmental capacity and regulate the developmental timing of tissue morphogenesis of the embryonic lineage.

细胞命运规范、分化和形态发生的基本过程必须精细同步才能实现适当的发育进程，然而协调这些过程的分子因素尚未得到很好的理解。胚胎形态发生的一个关键驱动因素是上皮极性的建立，这是早期细胞层的组织和结构。在这里，我们研究了控制外胚层细胞上皮化的因素，并在小鼠胚胎中实施了顺序功能丧失方法，以确定发育意义的时间。我们发现核心多能因子Oct4和Sox2在8细胞期之后的表达波在这一过程中起着关键作用。在这种情况下，这些因子的一个关键共享功能是防止上皮程序的过早激活，直到完成第二谱系分离。因此，Oct4和Sox2同时调控胚胎谱系组织形态发生的发育能力和发育时间。

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引用次数: 0

Un-LOX-ing tumor immune barriers 消除肿瘤免疫屏障

IF 11.8 1区生物学 Q1 CELL BIOLOGY

Developmental cell

Pub Date : 2025-12-01 DOI: 10.1016/j.devcel.2025.10.016

Tuyen T. Dang, Srinivas Malladi

In this issue of Developmental Cell, Zhang et al. report the identification of two transcriptionally distinct renal cell carcinoma tumor thrombus subtypes. The aggressive TT1 subtype is characterized by LOX-expressing cancer cells within an immunosuppressive microenvironment dominated by THBS2⁺ fibroblasts and GPNMB⁺ macrophages that exclude CD8⁺ T cells.

在这一期的Developmental Cell上，Zhang等报道了两种转录不同的肾细胞癌肿瘤血栓亚型的鉴定。侵袭性TT1亚型的特征是在免疫抑制微环境中表达lox的癌细胞，该微环境由THBS2+成纤维细胞和GPNMB+巨噬细胞主导，不包括CD8+ T细胞。

引用次数: 0

The symphony of shape: A feedback loop conducting zebrafish heart formation 形状的交响乐：一个引导斑马鱼心脏形成的反馈回路

IF 11.8 1区生物学 Q1 CELL BIOLOGY

Developmental cell

Pub Date : 2025-12-01 DOI: 10.1016/j.devcel.2025.10.003

Changchang Cao, Zheng Li, Li Wang

Organ structures formed during development dictate their physiological functions. In this issue of Developmental Cell, Andrews et al.¹ demonstrate a cellular feedback loop linking trabeculation and compact layer stretching, which depends on actomyosin remodeling mediated by the Notch signaling pathway and orchestrates ventricular morphogenesis in zebrafish.

发育过程中形成的器官结构决定了它们的生理功能。在本期《发育细胞》（Developmental Cell）杂志上，Andrews等人1展示了一个连接小梁形成和致密层拉伸的细胞反馈回路，该回路依赖于Notch信号通路介导的肌动yosin重塑，并协调斑马鱼的心室形态发生。

引用次数: 0

Combinatorial BMP4 and activin direct the choice between alternate routes to endoderm in a stem cell model of human gastrulation. 在人原肠胚干细胞模型中，组合BMP4和激活素指导通往内胚层的替代途径的选择。

IF 8.7 1区生物学 Q1 CELL BIOLOGY

Developmental cell

Pub Date : 2025-12-01 Epub Date: 2025-09-09 DOI: 10.1016/j.devcel.2025.08.009

Oliver C K Inge, Elias Copin, Jake Cornwall-Scoones, Borzo Gharibi, Irene Rodriguez-Hernandez, Pablo Soro-Barrio, Molly Strom, Probir Chakravarty, James Briscoe, Silvia D M Santos

Lineage specification requires accurate interpretation of multiple signaling cues. However, how combinatorial signaling histories influence fate outcomes remains unclear. We combined single-cell transcriptomics, live-cell imaging, and mathematical modeling to explore how activin and bone morphogenetic protein 4 (BMP4) guide fate specification during human gastrulation. We see that these signals interact both synergistically and antagonistically to drive fate decisions. We find that definitive endoderm arises from lineage convergence: a direct route from pluripotency and an indirect route via a mesoderm progenitor state. Cells pass through temporal windows of signaling competency, and the relative concentration of activin and BMP4 dictates the trajectory choice. The efficiency between routes is underpinned by a dual role of BMP4 in inducing mesoderm genes while promoting pluripotency exit. This work underscores that the combination of signals a cell is exposed to not only directs its final fate but also the developmental route taken, suggesting lineage convergence enhances robustness in fate specification.

谱系规范需要对多个信号线索进行准确的解释。然而，组合信号历史如何影响命运结果仍不清楚。我们结合单细胞转录组学、活细胞成像和数学模型来探索激活素和骨形态发生蛋白4 （BMP4）如何指导人类原肠胚形成过程中的命运规范。我们看到，这些信号相互作用，协同和对抗，以驱动命运的决定。我们发现最终的内胚层起源于谱系趋同：多能性的直接途径和中胚层祖细胞状态的间接途径。细胞通过信号能力的时间窗口，激活素和BMP4的相对浓度决定了轨迹的选择。BMP4在诱导中胚层基因和促进多能性退出的双重作用支持了途径之间的效率。这项工作强调，细胞所暴露的信号组合不仅指导其最终命运，而且还指导其所采取的发育路线，这表明谱系收敛增强了命运规范的稳健性。

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引用次数: 0

How to blossom in the cold: An mRNA acetylation-mediated regulatory switch in plants 如何在寒冷中开花：植物中mRNA乙酰化介导的调控开关

IF 11.8 1区生物学 Q1 CELL BIOLOGY

Developmental cell

Pub Date : 2025-12-01 DOI: 10.1016/j.devcel.2025.10.009

Jie Zhao, Mingjia Chen

Flowering plants have complex mechanisms that perceive ambient temperature and fine-tune flowering time. In this issue of Developmental Cell, Wu et al. reveal a mechanism of thermosensory regulation of flowering mediated by NAT10s-dependent N⁴-acetylcytidine modification of FLOWERING LOCUS M (FLM) transcripts to control differential alternative splicing of FLM.

开花植物有复杂的机制来感知环境温度和微调开花时间。在这一期的Developmental Cell中，Wu等揭示了通过nat10s依赖性n4 -乙酰胞苷修饰开花位点M （FLM）转录本介导的开花热感觉调控机制，以控制FLM的差异选择性剪接。

引用次数: 0

Cross-species interactome analysis uncovers a conserved selective autophagy mechanism for protein quality control in plants 跨物种相互作用组分析揭示了植物蛋白质量控制的保守选择性自噬机制

IF 11.8 1区生物学 Q1 CELL BIOLOGY

Developmental cell

Pub Date : 2025-12-01 DOI: 10.1016/j.devcel.2025.11.001

Víctor Sánchez de Medina Hernández, Marintia M. Nava-García, Anita Bianchi, Marion Clavel, Ranjith K. Papareddy, Lina Benchalel, Veselin I. Andreev, Varsha Mathur, Azadeh Mohseni, Marta García-León, Peng Gao, Juan Carlos de la Concepción, Lorenzo Picchianti, Nenad Grujic, Roksolana Kobylinska, Alibek Abdrakhmanov, Héloïse Duvergé, Gaurav Anand, Nils Leibrock, Juncai Ma, Margot Raffeiner, Timothy Scott Crawford, Luca Argirò, Mateusz Matuszkiewicz, Cheuk-Ling Wun, Jakob Valdbjørn Kanne, Anton Meinhart, Elisabeth Roitinger, Isabel Bäurle, Byung Ho Kang, Morten Petersen, Suayib Üstün, Yogesh Kulathu, Tim Clausen, Silvia Ramundo, Yasin Dagdas

引用次数: 0

Medulloblastoma stem cell programs: Molecular roadmaps of disease progression 髓母细胞瘤干细胞计划：疾病进展的分子路线图

IF 11.8 1区生物学 Q1 CELL BIOLOGY

Developmental cell

Pub Date : 2025-11-27 DOI: 10.1016/j.devcel.2025.10.018

Jamie Zagozewski, Parthiv Haldipur, Kathleen J. Millen, Tamra E. Werbowetski-Ogilvie

Over the last decade, an unprecedented number of sequencing studies have characterized the molecular landscape of pediatric brain cancers, including the highly heterogeneous tumor medulloblastoma (MB). Extensive MB profiling has enabled a much deeper understanding of the primitive neurodevelopmental programs that are hijacked during tumor progression. However, we have yet to successfully target and fully eradicate the putative stem and early progenitor cells that drive MB tumorigenesis. This goal will require better human models that faithfully recapitulate oncogenic events, a deeper understanding of the mechanisms governing cell fate decisions in the primary and metastatic compartments, and comprehensive validation studies of MB stem/progenitor cell molecular signatures extracted from bioinformatics datasets. In this perspective, we summarize the current knowledge of the developmental origins of MB and highlight the unmet needs pertaining to tumor modeling, characterization of molecular programs driving metastatic cells, and post-transcriptional regulation of cell fate.

在过去的十年中，前所未有的测序研究描绘了儿童脑癌的分子景观，包括高度异质性的肿瘤髓母细胞瘤（MB）。广泛的MB谱分析使得对肿瘤进展过程中被劫持的原始神经发育程序有了更深入的了解。然而，我们还没有成功地靶向和完全根除推定的驱动MB肿瘤发生的干细胞和早期祖细胞。这一目标将需要更好的人类模型，忠实地概括致癌事件，更深入地了解原发性和转移性区室中控制细胞命运决定的机制，以及从生物信息学数据集中提取的MB干细胞/祖细胞分子特征的全面验证研究。从这个角度来看，我们总结了目前对MB发育起源的了解，并强调了与肿瘤建模、驱动转移细胞的分子程序的表征以及细胞命运的转录后调节有关的未满足的需求。

引用次数: 0

Vitamin B6 preserves the stemness-like phenotypes and antitumor ability of CD8+ T cells 维生素B6保留了CD8+ T细胞的干细胞样表型和抗肿瘤能力

IF 11.8 1区生物学 Q1 CELL BIOLOGY

Developmental cell

Pub Date : 2025-11-27 DOI: 10.1016/j.devcel.2025.10.017

Jun Wu, Gen Li, Jiawen Zhou, Xuan Sun, Haoyu Wang, Haipeng Gong, Peng Jiang

引用次数: 0

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