Designed Monomers and Polymers最新文献

Polyaniline (PANI), due to the various and controllable shapes, the environmental stability, the excellent physical and chemical property, has gained significant attention. PANI with abundant morphologies were successfully prepared through adjusting and controlling the state of the initial micelle-like in the micelle-like system composed by aniline and organic acids with relatively weak intermolecular interaction. Although the influence of the inorganic salts on their morphology, including the surface and the diameter, was investigated, the influence of salt on the nucleation of PANI was still unclear. Therefore, PANI nanofibers were fabricated through the addition of inorganic salt such as NaCl, MgSO₄ and AlCl₃ into the micelle-like composed of aniline and D-camphor-10-sulfonic acid. The influence of types and concentration of inorganic salts, doped acids and temperature on PANI was studied by Transmission Electron Microscope (TEM), UV-vis and Fourier Transform Infrared Spectroscopy (FTIR) spectroscopy. In addition, in situ UV-vis and ¹H Nuclear Magnetic Resonance technology (NMR) were applied to observe the process of aniline polymerization, and it was indicated the polymerization rate of aniline changed after the addition of inorganic salt NaCl into the initial solution.

Polymers are a fundamental part of numerous industries and can be conjugated with many other materials and components to have a vast array of products. Biomaterials have been extensively studied for their application in pharmaceutical formulation development, tissue engineering, and biomedical areas. However, the native form of many polymers has limitations concerning microbial contamination, susceptibility, solubility, and stability. Chemical or physical modifications can overcome these limitations by tailoring the properties of polymers to meet several requirements. The polymer modifications are interdisciplinary, cutting across conventional materials, physics, biology, chemistry, medicine, and engineering limitations. Microwave irradiation has become a well-established technique for a few decades to drive and promote chemical modification reactions. This technique allows ease of temperature and power control to perform the synthesis protocols efficiently. Additionally, microwave irradiation contributes to green and sustainable chemistry. In this contribution, microwave-assisted polymer modifications were described with a special focus on their application in developing several novel dosage forms.

The current work aims to modify carboxymethyl cellulose (CMC) and polyvinylpyrrolidone (PVP) with copper oxide nanoparticles (CuO NPs) to obtain new nanocomposites of CMC, PVP, and CuO NPs (CMC/PVP/CuO NPs) with distinguished properties. The interaction between the components of the nanocomposites was suggested and supported by using Gaussian 09W 07 Software and the average particle size was manually determined from TEM images using ImageJ software developed at the National Institutes of Health (NIH). The preparation methods were optimized, and the obtained nanocomposites were characterized with suitable techniques to explore their characteristics and to help expect or predict the suitable fields of applications.

In this paper, polystyrene (PS)-based reduced graphene oxide (rGO) composites were prepared by mixing PS latex particles with graphene oxide (GO) and the following in-situ reduction. The structure and morphology of PS/rGO composites were characterized, and the effects of rGO content on the dielectric properties as well as thermal stability of PS/rGO composites were investigated. Results showed that rGO sheets armoured on the surface of PS particles and exhibited well dispersion in the PS matrix after hot compression. The introduction of rGO improved the dielectric properties of the composites remarkably. When rGO content was 0.12 vol%, the dielectric permittivity and breakdown strength of PS/rGO arrived at 6.3 at10² Hz and 107 kV/mm, with 50% and 35.4% enhancement compared to the pristine PS. Furthermore, PS/rGO presented better thermal stability than the pristine PS, but the overlapping of rGO sheets in PS matrix induced the instability of dielectric loss with frequency.

Thermoreversible colloidal suspensions/gels have attracted recent research attention in the field of biomedical applications. In this study, a novel thermoresponsive particle suspension with thermoreversible gelation properties has been prepared for biomedical application. First, polystyrene (PS) microspheres were synthesized by dispersion polymerization and poly diethyleneglycolmethylmethacrylate (PDEGMA) polymer were synthesized via free radical polymerisation. Then, the new developed thermoresponsive suspensions were prepared via physical adsorption of a thermoresponsive polymer, poly[di (ethylene glycol) methyl methacrylate] (PDEGMA), onto the surface of polystyrene microspheres. PDEGMA acts as a steric stabilizer and induces thermoreversible gelation via chain extending and collapsing below and above its lower critical solution temperature (LCST), respectively. Scanning electron microscopy (SEM), ¹H NMR spectroscopy, Gel permeation chromatography (GPC), UV-vis spectroscopy, Rheometric measurement were conducted to characterize the prepared particles, polymers and suspensions. SEM images show that monodisperse microspheres with the sizes range 1.5-3.5 μm were prepared. UV-vis measurements demonstrate thermoresponsive properties of PDEGMA. ¹H NMR and GPC analysis confirms structural properties of prepared PDEGMA. Tube inversion tests demonstrated that the aqueous suspensions of the particles and polymer exhibited thermoreversible fluid-to-gel transitions. Rheological characterization revealed that the viscoelastic properties of the prepared suspension/gels can be fine tuned. This enables applications of the prepared gels as scaffolds for three-dimensional (3D) cell cultures.

In this study, a composite modifier for wood impregnation is prepared, which is functional and environmentally friendly. The surface of silica sol was modified by using KH-560. The modified silica sol, melamine, and glyoxal were used as raw materials. The silica sol/melamine glyoxal resin (from now on referred to as Silica sol/MG) composite modifier was prepared based on in-situ polymerization. The physicochemical properties (viscosity, solid content and etc.) of the composite modifier were evaluated. The structural and thermal properties were characterized and analyzed by FTIR spectroscopy, particle size distribution, TG and DSC. The results showed that the viscosity and solid content of the composite modifier decreased with the increase in the mass of the silica sol. The FTIR spectroscopy showed peaks at 473 cm^-1 and 1101 cm^-1, which were assigned to bending and stretching vibrations of the Si-O-Si bond, respectively, indicating that the modified silica sol was successfully introduced into the MG resin. When the modified silica sol mass fraction was 30%-40%, the particle size distribution of the composite modifier was relatively uniform. TG analysis found that the thermal stability of the composite modifier was significantly improved compared with the unmodified resin. DSC analysis showed that adding the modified silica sol reduced the curing temperature of the modifier from 115.5 °C to 107.9 °C.

Various transition metal catalysts have been utilized for ethylene polymerization. Silver catalysts have attracted less attention as the catalysts, but are potential for production of high molecular weight polyethylene. Herein, we report that silver complexes with various N-heterocyclic carbene (NHC) ligands in combination with modified methylaluminoxane (MMAO) afford polyethylene with high molecular weight (melting point over 140°C). SEM observation showed that the produced polyethylene has ultra-high molecular weight. NMR investigation of the reaction between the silver complexes with organoaluminums indicate that the NHC ligands transfer from the silver complex to aluminum to produce NHC aluminum complexes. Ph₃C[B(C₆F₅)₄] abstract methyl group from the NHC aluminum complex to afford cationic aluminum complex. The NHC aluminum complex promoted ethylene polymerization in the presence of Ph₃C[B(C₆F₅)₄] and organoaluminums. NHC ligand also promoted ethylene polymerization in combination with MMAO to produce polyethylene with high melting point (140.7°C). Thus, the aluminum complexes are considered to be the actual active species in silver-catalyzed ethylene polymerization.

The donor-acceptor type π-conjugated polymers having heterole units were prepared by the reaction of a regioregular organometallic polymer having both reactive titanacyclopentadiene and electron-donor thiophene-2,5-diyl units in the main chain with electrophiles such as diphenyltin dichloride, dichlorophenylphosphine, and diiodophenylarsine. For example, a polymer having electron-accepting phosphole unit was obtained in 54% yield whose number-average molecular weight (M_n) and molecular weight distribution (M_w/M_n) were estimated as 3,000 and 1.9, respectively. The obtained polymer exhibits a high highest occupied molecular orbital (HOMO) and low lowest unoccupied molecular orbital (LUMO) energy levels (-5.13 eV and -3.25 eV, respectively) due to the electron-donating thiophene and electron-accepting phosphole units. Reflecting upon the alternating structure of thiophene and phosphole, the polymer exhibits a band gap energy level (E_g) of 1.78 eV which is narrower than that of a derivative of poly(thiophene) (E_g = 2.25 eV).

Polyhydroxyalkanoates (PHAs) are biopolymers that are produced within the microbial cells in the presence of excess carbon and nutrient limitation. Different strategies have been studied to increase the quality and quantity of this biopolymer which in turn can be utilized as biodegradable polymers replacing conventional petrochemical plastics. In the present study, Bacillus endophyticus, a gram-positive PHA-producing bacterium, was cultivated in the presence of fatty acids along with beta-oxidation inhibitor acrylic acid. A novel approach for incorporating different hydroxyacyl groups provided using fatty acids as co-substrate and beta-oxidation inhibitors to direct the intermediates to co-polymer synthesis was experimented. It was observed that higher fatty acids and inhibitors had a greater influence on PHA production. The addition of acrylic acid along with propionic acid had a positive impact, giving 56.49% of PHA along with sucrose which was 1.2-fold more than the control devoid of fatty acids and inhibitors. Along with the copolymer production, the possible PHA pathway functional leading to the copolymer biosynthesis was hypothetically interpreted in this study. The obtained PHA was analyzed by FTIR and ¹H NMR to confirm the copolymer production, which indicated the presence of poly3hydroxybutyrate-co-hydroxyvalerate (PHB-co-PHV), poly3hydroxybutyrate-co-hydroxyhexanoate (PHB-co-PHx).

Morphine is a widely used opioid analgesic. However, standard morphine dosages and administration methods exhibit a short half-life and pose a risk of respiratory depression. Sustained-release microspheres can deliver prolonged efficacy and reduce side effects. We present a new controlled-release morphine gelatine microsphere (MGM) prepared using an emulsification-crosslinking strategy. The gelatine microsphere design improves the bioavailability of morphine. And it not only increases the clinical analgesic efficacy but also the safety of clinical medication through a gradual, sustained release. Besides, we describe MGMs' preparation, release, pharmacodynamics, and pharmacokinetics. And the drug metabolism pathway. We calculate the release rate of morphine by measuring plasma morphine concentration over time and pharmacokinetic parameters. It optimized the manufacturing process of MGMs, which makes the analgesic effect have a longer duration. MGMs analgesic effect shows dose dependence. After they were administrated, MGMs were released more slowly. Peak concentration was reduced, and the relative bioavailability improved. It even reached 88.84%. Its pharmacokinetic process was consistent with the two-component first-order absorption model. MGMs deliver sustained-release and long-action pharmacokinetics. It shows design goals of improving drug bioavailability, prolonging drug residence time in vivo, and maintaining stable blood drug concentration.