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Design of novel temperature-resistant and salt-tolerant acrylamide-based copolymers by aqueous dispersion polymerization. 新型耐温耐盐丙烯酰胺基共聚物的水分散聚合设计。
IF 1.6 4区 化学 Q2 Chemical Engineering Pub Date : 2022-08-11 eCollection Date: 2022-01-01 DOI: 10.1080/15685551.2022.2111845
Xiang Li, Ye Ju, Yongkang Jia, Fenggang Liu, Guangpu Liu, Shuo Wang, Haoyi Wang, Shihua Mao, Jintao Yang, Guangyan Du

Development of polymer-based flooding technology to improve oil recovery efficiency, water dispersion copolymerization of acrylamide, cationic monomer methacryloxyethyltrimethyl ammonium chloride (METAC), and anionic monomer acrylic acid (AA) were carried out in aqueous ammonium sulfate solution with polyvinyl pyrrolidone (PVP) as the stabilizer. The copolymers were characterized by 1H-NMR, FT-IR, TG, and SEM to confirm that they were prepared successfully and exhibited excellent salt-resistant property. Moreover, the effect of the aqueous solution of ammonium sulfate (AS) concentration, stabilizer concentration, and initiator concentration on the viscosity and size were systematically investigated. To further improve the thermal endurance properties of copolymer, hydrophobic monomers with different alkyl chain lengths were added to the above system. The acrylamide-based quadripolymer possessed prominent thermal and salt endurance properties by utilizing the advantages of zwitterionic structure and hydrophobic monomer. With the temperature rising, the viscosity retention could reach 70.2% in the water and 63.8% in the saline. This work had expected to provide a new strategy to design polymers with excellent salinity tolerance and thermal-resistance performances.

以聚乙烯吡罗烷酮(PVP)为稳定剂,在硫酸铵水溶液中开发了提高采收率的聚合物驱技术、丙烯酰胺的水分散共聚、阳离子单体甲基丙烯氧基乙基三甲基氯化铵(METAC)和阴离子单体丙烯酸(AA)。通过1H-NMR、FT-IR、TG和SEM对共聚物进行了表征,证实了共聚物的制备成功,并表现出优异的耐盐性能。此外,系统考察了硫酸铵水溶液浓度、稳定剂浓度和引发剂浓度对溶液粘度和粒径的影响。为了进一步提高共聚物的耐热性能,在上述体系中加入了不同烷基链长的疏水单体。丙烯酰胺基四聚体利用两性离子结构和疏水单体的优点,具有优异的耐热性和耐盐性。随着温度的升高,粘度保留率在水中可达70.2%,在盐水中可达63.8%。这项工作有望为设计具有优异耐盐和耐热性能的聚合物提供一种新的策略。
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引用次数: 1
Drug Release and Cytotoxicity of Hyaluronic Acid and Zinc Oxide Gels, An In-Vitro Study. 透明质酸和氧化锌凝胶的体外药物释放和细胞毒性研究。
IF 1.6 4区 化学 Q2 Chemical Engineering Pub Date : 2022-07-24 eCollection Date: 2022-01-01 DOI: 10.1080/15685551.2022.2099647
Jaahnavi Lanka, Santhosh Kumar, Mohana Kumar B, Shama Rao, Shivaprasad Gadag, Usha Y Nayak

Hyaluronic acid (HA) is a naturally occurring biopolymer, with a remarkable wound healing property. Zinc-oxide non-eugenol is a material widely used for periodontal dressing in dentistry. However, it has been reported that zinc oxide non-eugenol is toxic to osteoblasts and fibroblasts. Hence, the present study aimed to evaluate the drug release and cytotoxicity of HA and zinc-oxide gels. Hydrogels of HA and zinc oxide were formulated with carbopol as a carrier. In vitro drug release was performed by UV spectrophotometry, dialysis, and vial bag methods. Cytotoxicity assessment of HA and zinc-oxide gels was performed in human periodontal ligament fibroblasts (HPdLF) and human gingival fibroblasts (hGFs). An inverted phase-contrast microscope was used to assess the morphological changes. At 24 and 48 hr, HPdLF cells showed the highest viability in 0.1% low molecular weight-HA (LMW-HA) with a median value of 131.9, and hGFs showed the highest viability in 5% LMW-HA with a median of 129.56. The highest viability of HPdLF cells was observed in 5% high molecular weight-HA (HMW-HA), with a median value of 127.11. hGFs showed the highest viability in 1% HMW-HA with a median value of 97.99. Within the limitations of the present study, we concluded that LMW-HA is more efficient than HMW-HA. Both HPdLF and hGF cells showed complete cell morbidity with zinc-oxide hydrogels. Therefore, zinc oxide-based gels in concentrations as low as 9% could be toxic intraorally to soft tissues that harbor gingival and periodontal ligament fibroblasts.

透明质酸(HA)是一种天然存在的生物聚合物,具有显著的伤口愈合性能。氧化锌非丁香酚是一种广泛应用于牙周敷料的材料。然而,有报道称氧化锌非丁香酚对成骨细胞和成纤维细胞有毒性。因此,本研究旨在评价透明质酸和氧化锌凝胶的药物释放和细胞毒性。以卡波醇为载体,配制了透明质酸和氧化锌的水凝胶。采用紫外分光光度法、透析法和小瓶袋法进行体外释药。研究了羟基磷灰石和氧化锌凝胶对人牙周韧带成纤维细胞(HPdLF)和牙龈成纤维细胞(hGFs)的细胞毒性。倒置相衬显微镜观察形态学变化。在24和48小时,HPdLF细胞在0.1%低分子量ha (LMW-HA)中表现出最高的活力,中位数为131.9;hGFs在5%低分子量ha中表现出最高的活力,中位数为129.56。高分子量ha (HMW-HA)浓度为5%时,HPdLF细胞活力最高,中位数为127.11。在1%的HMW-HA中,hgf的活力最高,中位数为97.99。在本研究的限制下,我们得出结论,低分子量ha比低分子量ha更有效。在氧化锌水凝胶作用下,HPdLF和hGF细胞均表现出完全的细胞发病率。因此,浓度低至9%的氧化锌凝胶可能对含有牙龈和牙周韧带成纤维细胞的软组织有毒性。
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引用次数: 2
Two new Cd(II)/Zn(II) coordination polymers: luminescence properties and synergistic treatment activity with ultrasound therapy on uterine fibroids. 两种新型Cd(II)/Zn(II)配位聚合物的发光特性及其与超声治疗子宫肌瘤的协同治疗活性。
IF 1.6 4区 化学 Q2 Chemical Engineering Pub Date : 2022-06-20 eCollection Date: 2022-01-01 DOI: 10.1080/15685551.2022.2088976
Hong-Mei Liu, Xiao-Na Shang

Through the self-assembly reaction of 5-substituted isophthalic acid and bis(imidazolyl) ligands with Cd(II) ion or Zn(II) ion, two new coordination polymers with the chemical formulae of [Cd(5-meo-ip)(bmip)]n (1) and [Zn(5-pro-ip)(bip)]n·2 n(H2O) (2) (5-meo-H2ip = 5-methoxyisophthalic acid, 5-pro-H2ip = 5-propoxyisophthalic acid, bmip = 1,3-bis(2-methylimidazolyl)propane bip = 1,3-bis(imidazolyl)propane) were successfully obtained and structurally characterized by a series of characterization techniques. Moreover, compounds 1-2 show intense blue luminescence at room temperature. Furthermore, the assessment of their treatment activity on the uterine fibroids combined with ultrasound therapy was evaluated and the specific mechanism was investigated at the same time. Firstly, the effect of compound treatment on uterine fibroids apoptosis was detected via flow cytometry. Next, the apoptotic signaling pathway activation was detected through the Caspase-3 and Caspase-8 Activity Assay Kit.

通过5-取代间苯二甲酸与双咪唑配体与Cd(II)离子或Zn(II)离子的自组装反应,得到了化学式为[Cd(5-meo-ip)(bmip)]n(1)和[Zn(5-pro-ip)(bip)]n·2n (H2O)(2)的两种新型配位聚合物(5-meo-H2ip = 5-甲氧基间苯二甲酸,5-pro-H2ip = 5-丙氧基间苯二甲酸,成功制备了1,3-双(2-甲基咪唑基)丙烷(bip = 1,3-双(咪唑基)丙烷),并通过一系列表征技术对其结构进行了表征。此外,化合物1-2在室温下表现出强烈的蓝色发光。评价其联合超声治疗子宫肌瘤的疗效,探讨其具体作用机制。首先,采用流式细胞术检测复方治疗对子宫肌瘤细胞凋亡的影响。接下来,通过Caspase-3和Caspase-8活性测定试剂盒检测凋亡信号通路的激活情况。
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引用次数: 1
Synthesis of carbazole-based dendritic conjugated polymer: a dual channel optical probe for the detection of I- and Hg2. 咔唑基枝状共轭聚合物的合成:用于检测I-和Hg2的双通道光学探针。
IF 1.6 4区 化学 Q2 Chemical Engineering Pub Date : 2022-06-20 eCollection Date: 2022-01-01 DOI: 10.1080/15685551.2022.2088977
Yimin Wu, Ling Zhang, Fudong Ma, Tao Ding, Ablikim Obolda

A new type of carbazole-based blue-emitting dendritic conjugated polymer, poly[(9,9-dioctyl)-2,7-fluorene-co-4,4',4"-triphenylamine-co-9-(4-(9H-carbazol-9-yl)butyl)-3,6-carbazole](P), was successfully synthesized by Suzuki coupling reaction. Chemical structures of monomers and polymer were verified by FI-IR and 1HNMR characterizations. We found that polymer showed a special selectivity and high sensitivity for I-. With the addition of I-, the fluorescent polymer solution was obviously quenched. The polymer showed a special detection effect on I-. However, the fluorescent polymer was obviously restored when Hg2+ was added to the P/I- system due to the large complexation between I- and Hg2+. The anti-interference experiments of probe P/I- showed that other background cations have a slight influence on detecting Hg2+, and the calculated detection limit of Hg2+ reached 9.7 × 10-8 M, which could be a potential application for a two-channel cyclic detection of I- and Hg2+. Additionally, it was found that the theoretical values were in agreement with the experimental data.

通过Suzuki偶联反应,成功合成了一种新型卡唑类发蓝枝状共轭聚合物聚[(9,9-二辛基)-2,7-芴-co-4,4′,4”-三苯胺-co-9-(4-(9h -卡唑-9-基)丁基)-3,6-咔唑](P)。单体和聚合物的化学结构通过FI-IR和1HNMR进行了表征。我们发现该聚合物对I-具有特殊的选择性和高灵敏度。随着I-的加入,荧光聚合物溶液明显淬灭。该聚合物对I-具有特殊的检测作用。然而,在P/I-体系中加入Hg2+后,由于I-与Hg2+之间的络合作用较大,荧光聚合物得到了明显的恢复。探针P/I-的抗干扰实验表明,其他背景阳离子对Hg2+的检测影响较小,Hg2+的计算检出限达到9.7 × 10-8 M,可用于I-和Hg2+的双通道循环检测。理论计算结果与实验数据吻合较好。
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引用次数: 2
Improvement of two Mn2+ coordination polymers on cognitive function of aged rats after anesthesia. 两种Mn2+配位聚合物对麻醉后老年大鼠认知功能的改善。
IF 1.6 4区 化学 Q2 Chemical Engineering Pub Date : 2022-06-20 eCollection Date: 2022-01-01 DOI: 10.1080/15685551.2022.2090678
Hao-Lin Zhang, Qiang Jia, Fen Tian, Hui Zhang

Two Mn2+ coordination polymers (CPs) with the scientific terms of {[Mn(TTPA)·(H2O)2]·H2O} n (1) and {[Mn(TTPA)·(H2TTPA)]·2DMSO} n (2) were favorably created on the basis of multidentate linking organic ligand 2,5-bis-(1,2,4-triazol-1-yl)-terephthalic acid (H2TTPA) in the conditions of solvent-presupposed thermal reaction. To measure the influence of two Mn2+ coordination polymers with novel structures, the ELISA assay and real-time RT-PCR assay were conducted in this present research. First of all, the ELISA assay was conducted to measure the content of inflammatory cytokines released into the hippocampal tissue. In addition to this, the relative expression of the TAU protein in the brain was further determined with real-time RT-PCR assay.

以多齿连接有机配体2,5-二-(1,2,4-三唑-1-基)对苯二甲酸(H2TTPA)为基础,在溶剂预设热反应条件下,制备了学名为{[Mn(TTPA)·(H2O)2]·H2O} n(1)和{[Mn(TTPA)·(H2TTPA)]·2DMSO} n(2)的Mn2+配位聚合物(CPs)。为了检测两种结构新颖的Mn2+配位聚合物的影响,本研究采用了ELISA法和实时RT-PCR法。首先,采用ELISA法测定释放到海马组织中的炎性细胞因子含量。此外,采用实时RT-PCR法进一步测定TAU蛋白在脑组织中的相对表达量。
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引用次数: 0
The preparation of novel AIE fluorescent microspheres by dispersion polymerization. 分散聚合法制备新型AIE荧光微球。
IF 1.6 4区 化学 Q2 Chemical Engineering Pub Date : 2022-06-13 eCollection Date: 2022-01-01 DOI: 10.1080/15685551.2022.2088969
Hui Wang, Zhizhou Liu, Xueyan Nan, Tong Wang, Xuming Sun, Liang He, Pengli Bai

An approach to prepare monodisperse polystyrene microspheres with aggregation-induced emission (AIE) characteristics has been developed which shows promising applications in fluorescence-encoding. The micron-sized, monodisperse polystyrene microspheres with AIE molecules were perfectly synthesized by two-stage dispersion polymerization. Fluorescent AIE monomer was synthesized by Suzuki reaction, confirmed by nuclear magnetic resonance (NMR). These AIE fluorogens (AIEgens) exhibited unique properties such as bright green emission in solid state and increased emission in tetrahydrofuran (THF) solution with the increase of water content. The influence of the AIE molecules concentration to microspheres synthesis was well investigated. The reaction conditions were optimized to obtain the functional polystyrene microspheres with a size distribution around 3%. The novel microspheres were characterized by scanning electron microscopy (SEM), confocal fluorescence microscope and flow cytometry. According to these results, two-stage dispersion polymerization was proved to be an efficient pathway for the preparation of AIE fluorescent and functionalized microspheres, which could be used in many biomedical industries.

研究了一种具有聚集致发射特性的单分散聚苯乙烯微球的制备方法,该方法在荧光编码中具有良好的应用前景。采用两段分散聚合法制备了具有AIE分子的微米级单分散聚苯乙烯微球。采用Suzuki反应合成了AIE荧光单体,并经核磁共振证实。这些AIE氟化物(AIEgens)在固体状态下具有亮绿色发光,在四氢呋喃(THF)溶液中随含水量的增加而增加发光。研究了AIE分子浓度对微球合成的影响。优化了反应条件,得到了粒径分布在3%左右的功能聚苯乙烯微球。采用扫描电镜、共聚焦荧光显微镜和流式细胞术对微球进行了表征。结果表明,两段分散聚合是制备AIE荧光微球和功能化微球的有效途径,可用于生物医药行业。
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引用次数: 0
Synthesis and characterization of dual-responsive poly(N-vinylcaprolactam-co-N-methylolacrylamide) nanogels 双响应型聚(n -乙烯基己内酰胺-co- n -甲基丙烯酰胺)纳米凝胶的合成与表征
IF 1.6 4区 化学 Q2 Chemical Engineering Pub Date : 2022-06-09 DOI: 10.1080/15685551.2022.2086412
N. M. Nizardo, Dzul Fadli Alimin, Maria L A D Lestari
ABSTRACT This article reports the synthesis of poly(N-vinylcaprolactam-co-N-methylolacrylamide) (P(NVCL-co-NMA)) nanogels and investigates their thermo-/pH-responsive behavior. The formation of nanogels was synthesized using free radical emulsion polymerization by varying the monomer composition of NVCL:NMA, and their molecular structure was characterized by 1H-NMR and FTIR. It was found that the nanogels were successfully prepared, and the nanogels exhibited LCST-type phase transition behavior. Cloud point transition temperature (Tc) was studied as a function of copolymer composition, MBA concentration, and pH of the solution by exploring their changes in turbidity using UV–vis spectrophotometer. Our studies reveal that Tc nanogels increased with increasing concentration of NMA, which is due to the hydrophilicity of NMA. Our research also demonstrated that the increase in MBA percentage could decrease the Tc of the synthesized nanogels. Interestingly, P(NVCL-co-NMA) nanogels showed not only a thermoresponsive behavior but also a pH response with increasing Tc in a strong acidic environment owing to the H-bonds within the polymer chains. The results show that nanogels with initial monomer composition of NVCL and NMA of 75% and 25%, respectively, and using 4% of MBA showed Tc around 35°C at pH 7.4. In addition, DLS studies also confirmed this result since the particle sizes became much larger after surpassing the temperature of 35°C. Due to this founding, such nanogels might have potential application in controlled release. Nevertheless, further studies regarding the adjustment of Tc are still needed.
摘要本文报道了聚(n -乙烯基己内酰胺-co- n -甲基丙烯酰胺)(P(NVCL-co-NMA))纳米凝胶的合成,并研究了其热/ ph响应行为。通过改变NVCL:NMA单体组成,采用自由基乳液聚合法合成纳米凝胶,并用1H-NMR和FTIR对其分子结构进行表征。结果表明,纳米凝胶制备成功,且表现出lcst型相变行为。通过紫外-可见分光光度计考察共聚物组成、MBA浓度和溶液pH的浊度变化,研究了云点转变温度(Tc)随溶液浊度变化的关系。我们的研究表明,Tc纳米凝胶随着NMA浓度的增加而增加,这是由于NMA的亲水性。我们的研究还表明,增加MBA的百分比可以降低合成的纳米凝胶的Tc。有趣的是,由于聚合物链内的氢键,P(NVCL-co-NMA)纳米凝胶在强酸性环境中不仅表现出热响应行为,而且随着Tc的增加也表现出pH响应。结果表明,初始单体组成分别为75%和25%的NVCL和NMA,添加4%的MBA的纳米凝胶在pH 7.4下,在35℃左右显示出Tc。此外,DLS研究也证实了这一结果,因为超过35℃后,颗粒尺寸变得更大。由于这一发现,这种纳米凝胶在控释方面可能具有潜在的应用前景。但是,对于Tc的调整,还需要进一步的研究。
{"title":"Synthesis and characterization of dual-responsive poly(N-vinylcaprolactam-co-N-methylolacrylamide) nanogels","authors":"N. M. Nizardo, Dzul Fadli Alimin, Maria L A D Lestari","doi":"10.1080/15685551.2022.2086412","DOIUrl":"https://doi.org/10.1080/15685551.2022.2086412","url":null,"abstract":"ABSTRACT This article reports the synthesis of poly(N-vinylcaprolactam-co-N-methylolacrylamide) (P(NVCL-co-NMA)) nanogels and investigates their thermo-/pH-responsive behavior. The formation of nanogels was synthesized using free radical emulsion polymerization by varying the monomer composition of NVCL:NMA, and their molecular structure was characterized by 1H-NMR and FTIR. It was found that the nanogels were successfully prepared, and the nanogels exhibited LCST-type phase transition behavior. Cloud point transition temperature (Tc) was studied as a function of copolymer composition, MBA concentration, and pH of the solution by exploring their changes in turbidity using UV–vis spectrophotometer. Our studies reveal that Tc nanogels increased with increasing concentration of NMA, which is due to the hydrophilicity of NMA. Our research also demonstrated that the increase in MBA percentage could decrease the Tc of the synthesized nanogels. Interestingly, P(NVCL-co-NMA) nanogels showed not only a thermoresponsive behavior but also a pH response with increasing Tc in a strong acidic environment owing to the H-bonds within the polymer chains. The results show that nanogels with initial monomer composition of NVCL and NMA of 75% and 25%, respectively, and using 4% of MBA showed Tc around 35°C at pH 7.4. In addition, DLS studies also confirmed this result since the particle sizes became much larger after surpassing the temperature of 35°C. Due to this founding, such nanogels might have potential application in controlled release. Nevertheless, further studies regarding the adjustment of Tc are still needed.","PeriodicalId":11170,"journal":{"name":"Designed Monomers and Polymers","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2022-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46275924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Cu(II)-based coordination polymer: catalytic properties and treatment activity on stroke 一种Cu(II)基配位聚合物:脑卒中的催化性能和治疗活性
IF 1.6 4区 化学 Q2 Chemical Engineering Pub Date : 2022-06-09 DOI: 10.1080/15685551.2022.2086396
Pengfei Gao, Ji-rong Liu
ABSTRACT A fresh Cu(II) coordination polymer, i.e., [Cu3(Hmbdc)2(mbdc)2(dmphen)2]n (1, H2mbdc = isophthalic acid, dmphen = 4,7-dimethyl-1,10-phenanthroline), has been generated with the hydrothermal reactions between Cu salts and the mixed ligands of 4,7-dimethyl-1,10-phenanthroline and isophthalic acid. Moreover, the catalytic activity of 1 was evaluated via degrading the Congo red with a method of Fenton with an excellent degradation efficiency of 95.8% at 100 min. Next, the application value of compound on stroke was assessed, and the related mechanisms were explored at the same time. First of all, the tumor necrosis factor-α and recombinant rat IL-1β content released into the plasma were determined with enzyme-linked immunosorbent assay detection kit. Besides, the activation of the HMGB1/TLR4 signaling pathway activation in cerebral vascular endothelial cells was also determined with real-time reverse transcription–polymerase chain reaction assay.
摘要用铜盐与4,7-二甲基-1,10-菲罗啉和对苯二甲酸的混合配体水热反应制备了Cu(II)配位聚合物[Cu3(Hmbdc)2(mbdc)2(dmphen)2]n (1,h2mbdc =异邻苯二甲酸,dmphen = 4,7-二甲基-1,10-菲罗啉)。并通过Fenton法对刚果红进行降解,评价了1的催化活性,在100 min降解效率达到95.8%。其次,评价了化合物对冲程的应用价值,同时探讨了相关机理。首先用酶联免疫吸附法检测试剂盒测定释放到血浆中的肿瘤坏死因子-α和重组大鼠IL-1β的含量。此外,还采用实时逆转录-聚合酶链反应法检测了脑血管内皮细胞HMGB1/TLR4信号通路的激活情况。
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引用次数: 0
Synthesis and characterization of some novel polythiophene derivatives containing pyrazoline 含吡唑啉的新型多噻吩衍生物的合成与表征
IF 1.6 4区 化学 Q2 Chemical Engineering Pub Date : 2022-06-09 DOI: 10.1080/15685551.2022.2086413
Vu Quoc Trung, Tran Thi Thuy Duong, Nguyen Thi Dua, N. N. Linh, Lai Dang Cuong, Dao Phuong Thao, Vo Khac Huy, Nguyen Hoang Ha Phuong, Nguyen Hien, Duong Khanh Linh, Vu Quoc Manh, N. T. Chinh, T. Hoang, L. Van Meervelt
ABSTRACT Eight polythiophene derivatives containing pyrazoline side groups were synthesized by a chemical oxidative coupling polymerization using FeCl3. The crystal structures of four monomers were determined which confirm the almost perpendicular orientation of the thiophene and pyrazoline rings, while the other substituents are more coplanar. Analyses of IR, 1H-NMR, Raman and UV-Vis spectra demonstrated that the suggested polymerization was successful to generate the synthesized polythiophenes with the expected structures. The morphology of the synthesized polythiophenes was studied by SEM. The different substituents attached to the 1- and 3-positions of the pyrazoline side chain led to differences in optical properties, electrical conductivity, and thermal stability of the synthesized polythiophenes. By adding a pyrazoline side chain to polythiophenes, some polymers achieve good solubility, electrical conductivity of about 1.3 × 10–6 S/cm, high fluorescence intensity (above 40,000 a.u.) at 505–550 nm and thermal stability up to 590°C in the air.
摘要以三氯化铁为原料,采用化学氧化偶联聚合法合成了8种吡唑啉侧基聚噻吩衍生物。测定了四种单体的晶体结构,证实了噻吩环和吡唑啉环几乎垂直的取向,而其他取代基更共面。IR、1H-NMR、Raman和UV-Vis光谱分析表明,所提出的聚合反应成功地生成了具有预期结构的合成聚噻吩。通过扫描电镜研究了合成的聚噻吩的形貌。吡唑啉侧链的1-和3-位上连接的取代基不同,导致合成的聚硫醇在光学性能、导电性和热稳定性方面存在差异。通过在聚噻吩中添加吡唑啉侧链,一些聚合物获得了良好的溶解性、约1.3×10–6 S/cm的电导率、505–550 nm的高荧光强度(超过40000 a.u.)和在空气中高达590°C的热稳定性。
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引用次数: 0
Zn(II) coordination polymers: therapeutic activity and nursing application values against coronary heart disease Zn(II)配位聚合物对冠心病的治疗作用及护理应用价值
IF 1.6 4区 化学 Q2 Chemical Engineering Pub Date : 2022-06-09 DOI: 10.1080/15685551.2022.2086397
Sheng-Min Sang, Min-Xia Zhang
ABSTRACT In the current research, two coordination polymers (CPs) have been produced solvothermally on the basis of a semi-rigid multifunctional tricarboxylate, i.e., 5-(3,4-dicarboxylphenoxy) nicotic acid (H3L), and the chemical compositions of the two compounds are [Zn(H2L)2(H2O)2] 1 and [Zn(HL)(2,2'-bpy)] (2, 2,2'-bpy = 2,2'-bipyridine), respectively. The structures and CHN analysis of both complexes were researched. The structural analysis results show that complex 1 features a 2D layered network with sql-type topology and complex 2 demonstrates a 2D layered network with uninodal hcb topology. The therapeutic activity and nursing application values of compounds against coronary heart disease were explored, and their relevant mechanism was assessed in meantime. The endothelin (ET) and prostacyclin (PGI2) contents released by the arterial endothelial cells into plasma were determined with ELISA assay. In addition to this, the alpha granule membrane protein 140 (GMP140) on the platelet was determined with real-time RT-PCR assay.
摘要在目前的研究中,以半刚性多官能三羧酸为原料,溶剂热法合成了两种配位聚合物,即5-(3,4-二羧基苯氧基)烟酸(H3L),其化学组成分别为[Zn(H2L)2(H2O)2]1和[Zn(HL)(2,2'-bpy)](2,2,2'-ppy=2,2'-联吡啶)。对两种配合物的结构和CHN分析进行了研究。结构分析结果表明,复合体1具有sql型拓扑的二维分层网络,复合体2具有单峰hcb拓扑的二维层状网络。探讨了复方制剂对冠心病的治疗作用和护理应用价值,并对其相关机理进行了评价。用ELISA法测定动脉内皮细胞向血浆中释放的内皮素(ET)和前列环素(PGI2)含量。除此之外,用实时RT-PCR测定法测定血小板上的α颗粒膜蛋白140(GMP140)。
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引用次数: 1
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Designed Monomers and Polymers
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