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Preparation and Characterization of Carborane Modified Liquid Fluoroelastomers and the investigation of their properties. 碳硼烷改性液体氟弹性体的制备、表征及性能研究。
IF 1.6 4区 化学 Q2 Chemical Engineering Pub Date : 2021-06-21 DOI: 10.1080/15685551.2021.1935014
Juan Li

The preparation of liquid fluoroelastomers that are liquid with excellent mechanical properties remains a challenge. Here, we show a very straightforward method to produce liquid fluoroelastomers by introducing carborane. Carborane-terminated liquid fluoropolymer was synthesized by Steglich reaction of carboxyl-terminated liquid fluoropolymer and 1,7-bis (hydroxy)-carborane. The product is brown, viscous at room temperature and in the semi-solid state. On this basis, HDI Trimer was used as a curing agent to cure liquid fluoroelastomer. Thermogravimetric analysis of the cured products was carried out. The carbon residue rate of the cured product increased from 35% to 58% of the cured product. The results show that the addition of carborane structure can effectively improve the carbon residue rate of liquid fluoroelastomer. The tensile strength, elongation and shore hardness of the cured product were also examined, and the results show that the tensile strength of carborane modified liquid fluorine increased by 463% compared with that before modification, but the elongation at break was reduced by 42%, which was mainly due to the introduction of rigid structure of carborane. At the same time, the solvent resistance test results show that the introduction of carborane structure has little effect on the aviation kerosene resistance and organic solvent resistance of fluororubber, but it can improve its alkali resistance.

制备具有优异机械性能的液态氟弹性体仍然是一个挑战。在这里,我们展示了一种非常简单的方法,通过引入碳硼烷来生产液体氟弹性体。以端羧基液态氟聚合物与1,7-双(羟基)碳硼烷为原料,采用Steglich反应合成端碳硼烷液态氟聚合物。该产品呈棕色,在室温下呈粘性,为半固态。在此基础上,采用HDI三聚体作为固化剂固化液态氟弹性体。对固化产物进行了热重分析。固化产品的残碳率由固化产品的35%提高到58%。结果表明,碳硼烷结构的加入能有效提高液体氟弹性体的残碳率。对固化产物的抗拉强度、伸长率和邵氏硬度进行了测试,结果表明,碳硼烷改性液氟的抗拉强度比改性前提高了463%,但断裂伸长率下降了42%,这主要是由于碳硼烷的刚性结构的引入。同时,耐溶剂性试验结果表明,碳硼烷结构的引入对氟橡胶的耐航空煤油性和耐有机溶剂性影响不大,但能提高氟橡胶的耐碱性。
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引用次数: 1
A new trinuclear cluster-based Cd(II) compound: photocatalytic property and nursing application values on the bacterial infection. 一种新的三核团簇镉(II)化合物:光催化特性及对细菌感染的护理应用价值。
IF 1.6 4区 化学 Q2 Chemical Engineering Pub Date : 2021-05-31 DOI: 10.1080/15685551.2021.1935010
Yan Hu, Jiao Ni

A new Cd(II) coordination polymer with the formula of {[(CH3)2NH2][Cd3(NH2-bdc)3(btz)(H2O)]} n (1 NH2-H2bdc = 2-aminoterephthalic acid, Hbtz = 1 H-benzotriazole) was produced and then it was structurally characterized through powder X-ray diffraction (PXRD), the analysis of X-ray single-crystal diffraction, along with elemental analysis (EA). The photocatalytic property investigations indicate that compound 1 exhibits good activity for photodegradation of methyl violet (MV) with 60.7% of MV removal in 40 min under room temperature. Furthermore, the assessment of the compound's treatment activity and nursing application values on the bacterial infection was conducted and its corresponding mechanism was also studied. Evaluation of the in vitro hemolysis of the compound was determined by measuring the degree of red blood cell lysis and hemoglobin release. The effect of new compounds on the relative proliferation rate of L-929 cells was measured by MTT assay. The ELISA detection kit showed that the compound could reduce the TNF-α and IL-1β content released into plasma. Next, the inhibitory activity of the compound on the bacterial survival gene expression was also proved with real-time RT-PCR. The hemolysis rate of the new compound to blood is 3.4%, which is less than the standard 5%, which is non-hemolytic reaction. The compound also has no obvious cytotoxicity and has good cell compatibility.

通过粉末 X 射线衍射 (PXRD)、X 射线单晶衍射分析和元素分析 (EA),制备了一种新的镉(II) 配位聚合物,其分子式为 {[(CH3)2NH2][Cd3(NH2-bdc)3(btz)(H2O)]} n (1 NH2-H2bdc = 2- 氨基对苯二甲酸,Hbtz = 1 H-苯并三唑)。光催化性能研究表明,化合物 1 对甲基紫(MV)具有良好的光降解活性,室温下 40 分钟内甲基紫的去除率为 60.7%。此外,还评估了化合物对细菌感染的治疗活性和护理应用价值,并研究了其相应的机理。通过测量红细胞溶解度和血红蛋白释放量,对化合物的体外溶血作用进行了评估。用 MTT 法测定了新化合物对 L-929 细胞相对增殖率的影响。ELISA 检测试剂盒显示,化合物能降低血浆中释放的 TNF-α 和 IL-1β 含量。此外,实时 RT-PCR 也证明了该化合物对细菌存活基因表达的抑制作用。新化合物对血液的溶血率为 3.4%,低于标准的 5%,属于非溶血反应。该化合物也没有明显的细胞毒性,具有良好的细胞相容性。
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引用次数: 0
The surface morphology and dynamic impact properties with rebounding and splashing of water droplet on phase separation and breath figure assisted electrospinning films. 相分离和呼吸图辅助静电纺丝膜表面形貌及水滴回弹和溅射的动态冲击性能。
IF 1.6 4区 化学 Q2 Chemical Engineering Pub Date : 2021-05-25 DOI: 10.1080/15685551.2021.1930670
Que Kong, Zhiguang Li, Xuehong Ren, Hao Gu, Wujun Ma

Electrospinning provides a versatile, efficient and low-cost method for the preparation of continuous nanofibres from various polymers. In this study, the polyhedral oligomeric silsesquioxanes (POSS) block copolymer was synthesized via atom transfer radical polymerization. The smooth fiber, porous fiber or hierarchically porous microspheres were prepared by electrospinning from POSS block copolymer, poly(vinylidene fluoride) (PVDF) and aluminium oxide (Al2O3). The influence of copolymer concentration, the ratio of the solvents, the diameter and concentration of the Al2O3 on the surface morphology were investigated. Porous fibers and porous microspheres were prepared by regulating the ratio of the solvents from the phase separation and breath figure methods. The dynamic behavior of the water droplet with the constant volume impacting on the electrospinning films were reported. The morphology evolution, restitution coefficient, the change of energy of the water droplets are examined. The droplet bounces several times on the superhydrophobic surface, while the droplet remains pinned and does not rebound when the contact angles was lower than 150°. On the other hand, the water droplets were splashed on the Al2O3 based electrospinning films. Finally, the mechanical properties of the electrospinning films were investigated.

静电纺丝技术为从各种聚合物中制备连续纳米纤维提供了一种多功能、高效和低成本的方法。本研究采用原子转移自由基聚合法合成了多面体低聚硅氧烷(POSS)嵌段共聚物。以POSS嵌段共聚物、聚偏氟乙烯(PVDF)和氧化铝(Al2O3)为原料,采用静电纺丝法制备了光滑纤维、多孔纤维或分层多孔微球。考察了共聚物浓度、溶剂配比、Al2O3粒径和浓度对表面形貌的影响。采用相分离法和呼吸图法,通过调节溶剂的比例制备了多孔纤维和多孔微球。报道了等体积水滴对静电纺丝膜的动力学行为。研究了水滴的形态演变、恢复系数和能量变化。液滴在超疏水表面多次反弹,而当接触角小于150°时,液滴保持固定不反弹。另一方面,水滴溅落在氧化铝基静电纺丝膜上。最后,对静电纺丝膜的力学性能进行了研究。
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引用次数: 6
Drug release and magneto-calorific analysis of magnetic lipid microcapsules for potential cancer therapeutics. 磁性脂质微胶囊用于潜在癌症治疗的药物释放和磁热分析。
IF 1.6 4区 化学 Q2 Chemical Engineering Pub Date : 2021-05-18 DOI: 10.1080/15685551.2021.1929684
Hongmei Bi, Zeqin Chen, Jiaqin Qiu

Magnetic nanoparticles (MNPs) with safety, stability and excellent magneto-calorific effect are the precondition for the smart magnetic drug carriers' fabrication and controllable drug release at a specific target in clinical treatment. In this study, the drug release and magneto-calorific effect of two types of magnetic lipid microcapsules (MLMs) loading lipid-coated MNPs and uncoated MNPs respectively were compared deeply in experimental analysis and theoretical simulation. The simulation results revealed that almost same magnetic heat effect and temperature increasing exist between lipid-coated and uncoated MNPs, which was consistent with the experimental drug release results. Coating lipid on MNPs didn't affect the magnetic heat and heat transfer of the MNPs. Because of the heat transfer between MNPs and water, MLMs and water around, the temperature increasing of whole sample solution is lower than that of the MNPs themselves. Our results provide a reliable theoretical basis for the development of healthy, safe, and biocompatible drug delivery systems.

具有安全、稳定和优异磁热效应的磁性纳米颗粒是制备智能磁性药物载体和实现药物在特定靶点可控释放的前提条件。本研究通过实验分析和理论模拟,对两种磁性脂质微胶囊(MLMs)分别装载脂质包被MNPs和未包被MNPs的药物释放和磁热效应进行了深入的比较。模拟结果表明,脂包被与未包被MNPs之间存在几乎相同的磁热效应和温度升高,这与实验药物释放结果一致。在MNPs表面涂覆脂对MNPs的磁热和传热没有影响。由于MNPs与水、MLMs与周围水之间的热传递,整个样品溶液的温升低于MNPs本身的温升。本研究结果为开发健康、安全、具有生物相容性的给药系统提供了可靠的理论基础。
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引用次数: 4
A new thermostable Cu(II) coordination polymer: photocatalytic activity and application values on diabetes. 一种新型耐热Cu(II)配位聚合物:光催化活性及其在糖尿病中的应用价值。
IF 1.6 4区 化学 Q2 Chemical Engineering Pub Date : 2021-05-07 DOI: 10.1080/15685551.2021.1921341
Chen-Lu Jin, Shao-Jun Fang, Li Yu, Zhen-Shan Guo

A Cu(II) coordination polymer with the composition of [Cu2(L)2(4,4'-bipy)2]n·2 n(ClO4) (1, HL = 4-methyl-L-phenylalanine and 4,4'-bipy is 4,4'-bipyridine), was successfully obtained by the reaction of the mixed ligand of HL and 4,4'-bipy with Cu(ClO4)2 · 6H2O under solvothermal condition. The as-synthesized compound not only has high thermal stability until 275°C but also excellent photocatalytic activity for the methyl blue solution degradation under the irradiation of ultraviolet light. Furthermore, the compound's treatment activity on the diabetes was determined and its relevant mechanism was also studied. The cytotoxicity or hemolysis toxicity (HC50) of the synthesized compound was also evaluated in this research.

在溶剂热条件下,将HL和4,4'-bipy的混合配体与Cu(ClO4)2·6H2O反应,成功制备了一种由[Cu2(L)2(4,4'-bipy)2]n·2n (ClO4) (1,hl = 4-甲基-L-苯丙氨酸,4,4'-bipy = 4,4'-联吡啶)组成的Cu(II)配位聚合物。所合成的化合物不仅在275℃前具有较高的热稳定性,而且在紫外光照射下对甲基蓝溶液的降解具有优异的光催化活性。进一步测定了该化合物对糖尿病的治疗活性,并对其作用机制进行了研究。本研究还对所合成化合物的细胞毒性或溶血毒性(HC50)进行了评价。
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引用次数: 4
New type of borneol-based fluorine-free superhydrophobic antibacterial polymeric coating. 新型龙脑基无氟超疏水抗菌聚合物涂料。
IF 1.6 4区 化学 Q2 Chemical Engineering Pub Date : 2021-05-07 DOI: 10.1080/15685551.2021.1924959
Xin Chen, Yuexing Chen, Sengwei Lv, Lingling Zhang, Rulan Ye, Chuchu Ge, Dayun Huang, Sihai Zhang, Zaisheng Cai

A new type of superhydrophobic borneol-based polymeric coating has been prepared. The chemical composition of the polymer particles was analyzed by Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy, which showed that the polymer did not contain fluorine, which can effectively avoid the cytotoxic risk of fluorine. By dynamic light scattering, scanning electron microscopy, and static contact angle measurement, the contact angle of the prepared coating gradually increased with increasing diameter of the polymer particles, and a superhydrophobic coating surface was finally obtained. Interestingly, after dissolving the superhydrophobic sample with tetrahydrofuran and making it a normal hydrophobic sample, the antiadhesion performance for E. coli was greatly reduced, and it could not effectively prevent E. coli adhesion. In addition, a long-term antiadhesion study of bacteria was performed. The superhydrophobic borneol-based polymer coating showed long-term resistance to E. coli adhesion. Therefore, the excellent antibacterial properties and cell compatibility mean that this series of polymer materials has great potential in the field of biomedicine.

制备了一种新型的超疏水冰片基聚合物涂料。通过傅立叶变换红外光谱和X射线光电子能谱分析了聚合物颗粒的化学成分,表明聚合物不含氟,可以有效避免氟的细胞毒性风险。通过动态光散射、扫描电子显微镜和静态接触角测量,所制备的涂层的接触角随着聚合物颗粒直径的增加而逐渐增大,最终获得了超疏水涂层表面。有趣的是,用四氢呋喃溶解超疏水性样品并使其成为正常疏水性样品后,对大肠杆菌的抗粘附性能大大降低,并且不能有效防止大肠杆菌粘附。此外,还对细菌进行了长期的抗粘附研究。基于冰片的超疏水聚合物涂层显示出对大肠杆菌粘附的长期抗性。因此,该系列聚合物材料具有优异的抗菌性能和细胞相容性,在生物医学领域具有巨大的潜力。
{"title":"New type of borneol-based fluorine-free superhydrophobic antibacterial polymeric coating.","authors":"Xin Chen,&nbsp;Yuexing Chen,&nbsp;Sengwei Lv,&nbsp;Lingling Zhang,&nbsp;Rulan Ye,&nbsp;Chuchu Ge,&nbsp;Dayun Huang,&nbsp;Sihai Zhang,&nbsp;Zaisheng Cai","doi":"10.1080/15685551.2021.1924959","DOIUrl":"10.1080/15685551.2021.1924959","url":null,"abstract":"<p><p>A new type of superhydrophobic borneol-based polymeric coating has been prepared. The chemical composition of the polymer particles was analyzed by Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy, which showed that the polymer did not contain fluorine, which can effectively avoid the cytotoxic risk of fluorine. By dynamic light scattering, scanning electron microscopy, and static contact angle measurement, the contact angle of the prepared coating gradually increased with increasing diameter of the polymer particles, and a superhydrophobic coating surface was finally obtained. Interestingly, after dissolving the superhydrophobic sample with tetrahydrofuran and making it a normal hydrophobic sample, the antiadhesion performance for <i>E. coli</i> was greatly reduced, and it could not effectively prevent <i>E. coli</i> adhesion. In addition, a long-term antiadhesion study of bacteria was performed. The superhydrophobic borneol-based polymer coating showed long-term resistance to <i>E. coli</i> adhesion. Therefore, the excellent antibacterial properties and cell compatibility mean that this series of polymer materials has great potential in the field of biomedicine.</p>","PeriodicalId":11170,"journal":{"name":"Designed Monomers and Polymers","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2021-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/15685551.2021.1924959","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39074067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Theoretical design of low bandgap donor-acceptor (D-A) monomers for polymer solar cells: DFT and TD-DFT study. 聚合物太阳能电池低带隙给受体(D-A)单体的理论设计:DFT和TD-DFT研究。
IF 1.6 4区 化学 Q2 Chemical Engineering Pub Date : 2021-05-05 DOI: 10.1080/15685551.2021.1921923
Said A H Vuai, Numbury Surendra Babu

Endeavors have been made to construct new donor-acceptor (D-A) monomers utilizing 9 H-carbazole (CB) as electron donors and different electron acceptors. All estimations were finished using DFT and TD-DFT, and B3LYP level with a 6-311 G basis set in the gas and chloroform solvent. The impacts of the distinctive acceptors on the geometry of molecules and optoelectronic properties of these D-A monomers were discussed to dissect the connection connecting the molecular structures and the optoelectronic properties. Likewise, the HOMO - LUMO energies, atomic orbital densities are calculated theoretically. Notwithstanding the charge transfer measure between the carbazole electron donor unit and the electron acceptor one is upheld by breaking down the optical spectra of the acquired monomers and the restriction of involved HOMO and LUMO. The outcomes show that the D-A monomers, CB-ODP, CB-TDP, and CB-SDP, are acceptable for optoelectronic applications in organic solar cells like BHJ.

利用9个h -咔唑(CB)作为电子给体和不同的电子受体,构建了新的给体-受体(D-A)单体。所有的估计都是用DFT和TD-DFT完成的,B3LYP水平在6-311 G的基础上设置在气体和氯仿溶剂中。讨论了不同受体对这些D-A单体分子几何结构和光电子性能的影响,剖析了分子结构和光电子性能之间的联系。同样,HOMO - LUMO的能量和原子轨道密度也从理论上计算出来。通过分解所得单体的光谱和所涉及的HOMO和LUMO的限制,支持了咔唑电子给体单元和电子受体单元之间的电荷转移。结果表明,D-A单体CB-ODP、CB-TDP和CB-SDP可用于BHJ等有机太阳能电池的光电应用。
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引用次数: 2
Bioinspired double self-adhesion coating based on dopamine, coating resin and phosphorylcholine for surface lubrication and antifouling functionalization. 基于多巴胺、涂层树脂和磷胆碱的仿生双自粘涂层,用于表面润滑和防污功能化。
IF 1.6 4区 化学 Q2 Chemical Engineering Pub Date : 2021-04-22 DOI: 10.1080/15685551.2021.1919389
Qipeng Li, Qiuxiang Yin, Baohong Hou, Ling Zhou

Implanted medical devices that have poor friction property or biofilm formation can limit their service life and cause discomfort in patients. Recently, some zwitterionic coatings have been studied to modify the biomaterials surface for lubricating function, but the grafting methods of coatings are complicated and also seldom take the bacterial antiadhesion property into account at the same time. In our studies, motivated by the properties of nature mussels and human articular, we firstly successfully synthesized double adhesion protection of self-adhesive ternary polymer coating and achieved the excellent lubrication and antifouling functionalization of the medical devices surface. In details, the X-ray photoelectron spectroscopy, scanning electron microscope and the water contact angles could characterize the successful modification on the surface of titanium substrate. Additionally, the tribological tests carried out by atomic force microscope verified the ternary polymer could enhance the lubrication property owing to the hydration lubrication mechanism. Meanwhile, it also possessed the bacterial antiadhesion property for the initial 24 h attributed to the hydration repulsive force. We believe that, as a simple and universal preparation method, the ternary polymer could make a great significance for improving the surface function of biomaterials and alleviating patients' discomfort.

植入式医疗器械摩擦性能差或形成生物膜会限制其使用寿命,并引起患者不适。近年来,人们研究了一些两性离子涂层来修饰生物材料的表面,使其具有润滑功能,但涂层的接枝方法复杂,同时也很少考虑到细菌的抗粘附性。在我们的研究中,我们以自然贻贝和人体关节的特性为动力,首次成功合成了双粘附保护的自粘三元聚合物涂层,实现了医疗器械表面优异的润滑和防污功能化。x射线光电子能谱、扫描电镜和水接触角表征了钛基表面改性的成功进行。原子力显微镜下的摩擦学试验验证了三元聚合物由于水化润滑机制而提高了润滑性能。同时,由于水合斥力的作用,在初始24 h内还具有抗细菌粘附性能。我们认为,三元聚合物作为一种简单通用的制备方法,对于改善生物材料的表面功能,减轻患者的不适具有重要意义。
{"title":"Bioinspired double self-adhesion coating based on dopamine, coating resin and phosphorylcholine for surface lubrication and antifouling functionalization.","authors":"Qipeng Li, Qiuxiang Yin, Baohong Hou, Ling Zhou","doi":"10.1080/15685551.2021.1919389","DOIUrl":"10.1080/15685551.2021.1919389","url":null,"abstract":"<p><p>Implanted medical devices that have poor friction property or biofilm formation can limit their service life and cause discomfort in patients. Recently, some zwitterionic coatings have been studied to modify the biomaterials surface for lubricating function, but the grafting methods of coatings are complicated and also seldom take the bacterial antiadhesion property into account at the same time. In our studies, motivated by the properties of nature mussels and human articular, we firstly successfully synthesized double adhesion protection of self-adhesive ternary polymer coating and achieved the excellent lubrication and antifouling functionalization of the medical devices surface. In details, the X-ray photoelectron spectroscopy, scanning electron microscope and the water contact angles could characterize the successful modification on the surface of titanium substrate. Additionally, the tribological tests carried out by atomic force microscope verified the ternary polymer could enhance the lubrication property owing to the hydration lubrication mechanism. Meanwhile, it also possessed the bacterial antiadhesion property for the initial 24 h attributed to the hydration repulsive force. We believe that, as a simple and universal preparation method, the ternary polymer could make a great significance for improving the surface function of biomaterials and alleviating patients' discomfort.</p>","PeriodicalId":11170,"journal":{"name":"Designed Monomers and Polymers","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2021-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/15685551.2021.1919389","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38964649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reduction-sensitive N, N'-Bis(acryloyl) cystinamide-polymerized Nanohydrogel as a Potential Nanocarrier for Paclitaxel Delivery. 对还原敏感的 N,N'-双(丙烯酰)胱氨酰胺聚合纳米水凝胶作为紫杉醇递送的潜在纳米载体
IF 1.6 4区 化学 Q2 Chemical Engineering Pub Date : 2021-04-18 DOI: 10.1080/15685551.2021.1914398
Linna Yu, Lingping Kong, Junpeng Xie, Wei Wang, Chen Chang, Hongli Che, Mingzhe Liu

Novel monomer, N, N'-bis(acryloyl) cystinamide (NBACA), was designed and synthesized with L-cystine as row material. By using this NBACA both as the monomer and crosslinker, reduction-sensitive nanohydrogel was prepared in ethanol via distillation-precipitation polymerization. The obtained nanohydrogel can provide a relatively hydrophobic environment and hydrogen-bonding sites inside the gel; therefore, it is suitable for loading hydrophobic drug. When paclitaxel that possess poor water-solubility was used as a model drug, the nanohydrogel represented a high drug-loading capacity, and dispersed well in aqueous solutions. Furthermore, the disulfide-group-containing nanohydrogel exhibited good reduction-sensitive drug-release behavior. The nanohydrogel biodegraded rapidly in a reducing environment, and released approximately 80% of the PTX within 24 h. Cytotoxicity assays showed that the PTX-loaded nanohydrogel exhibited high cytotoxicity against MCF-7 breast cancer cells, while blank nanohydrogels displayed a negligible cytotoxicity.

以 L-胱氨酸为原料,设计并合成了新型单体 N,N'-双(丙烯酰)胱氨酰胺(NBACA)。利用这种 NBACA 作为单体和交联剂,在乙醇中通过蒸馏沉淀聚合法制备了还原敏感性纳米水凝胶。得到的纳米水凝胶可以在凝胶内部提供相对疏水的环境和氢键位点,因此适合负载疏水性药物。当以水溶性较差的紫杉醇为模型药物时,纳米水凝胶具有较高的药物负载能力,在水溶液中分散良好。此外,含二硫键的纳米水凝胶还表现出良好的还原敏感性药物释放行为。细胞毒性实验表明,负载 PTX 的纳米水凝胶对 MCF-7 乳腺癌细胞具有很高的细胞毒性,而空白纳米水凝胶的细胞毒性则微乎其微。
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引用次数: 0
Ring-opening polymerization of ε-caprolactone initiated by tin(II) octoate/n-hexanol: DSC isoconversional kinetics analysis and polymer synthesis. 八酸锡/正己醇引发ε-己内酯开环聚合:DSC等转化动力学分析及聚合物合成
IF 1.6 4区 化学 Q2 Chemical Engineering Pub Date : 2021-04-11 DOI: 10.1080/15685551.2021.1908657
Winita Punyodom, Wanich Limwanich, Puttinan Meepowpan, Boontharika Thapsukhon

The kinetics of ring-opening polymerization (ROP) of ε-caprolactone (ε-CL) initiated by 1.0, 1.5 and 2.0 mol% of stannous(II) octoate/n-hexanol (Sn(Oct)2/n-HexOH) wase successfully studied by non-isothermal differential scanning calorimetry (DSC) at heating rates of 5, 10, 15 and 20 °C/min. The DSC polymerization kinetic parameters of ε-CL were calculated using differential (Friedman) and integral isoconversional methods (Kissinger-Akahira-Sunose, KAS). The average activation energy (Ea ) values obtained from Friedman and KAS methods were in the range of 64.9-70.5 kJ/mol and 64.9-80.4 kJ/mol, respectively. The values of frequency factor (A) were determined from model fitting method using Avrami-Erofeev reaction model. The average values of A for the ROP of ε-CL initiated by 1.0, 1.5 and 2.0 mol% of Sn(Oct)2/n-HexOH (1:2) were 7.3x107, 2.8x106 and 1.2x106 min-1, respectively. From kinetics studied, the polymerization rate of ε-CL increased with increasing initiator concentration. The performance of Sn(Oct)2/n-HexOH in the synthesis of poly(ε-caprolactone) (PCL) was investigated by bulk polymerization at temperatures of 140, 160 and 180 °C. Sn(Oct)2/n-HexOH (1:2) could produce high number average molecular weight ( M n = 9.0 × 104 g/mol) and %yield (89%) of PCL in a short period of time at Sn(Oct)2 concentration of 0.1 mol% and temperature of 160°C. The mechanism of the ROP of ε-CL with Sn(Oct)2/n-HexOH was proposed through the coordination-insertion mechanism.

采用非等温差示扫描量热法(DSC)研究了1.0、1.5和2.0 mol%的八酸锡/正己醇(Sn(Oct)2/正己醇)溶液在5、10、15和20℃/min加热速率下引发ε-己内酯(ε-CL)开环聚合(ROP)的动力学。采用微分法(Friedman)和积分等转换法(Kissinger-Akahira-Sunose, KAS)计算了ε-CL的DSC聚合动力学参数。Friedman法和KAS法得到的平均活化能(Ea)分别在64.9 ~ 70.5 kJ/mol和64.9 ~ 80.4 kJ/mol之间。频率因子(A)采用Avrami-Erofeev反应模型拟合。当Sn(Oct)2/n-HexOH浓度为1.0、1.5和2.0 mol%(1:2)时,ε-CL的ROP平均值分别为7.3x107、2.8x106和1.2x106 min-1。从动力学研究来看,ε-CL的聚合速率随引发剂浓度的增加而增加。采用本体聚合的方法研究了Sn(Oct)2/n-HexOH在140、160和180℃条件下合成聚ε-己内酯(PCL)的性能。Sn(Oct)2/n- hexoh(1:2)在Sn(Oct)2浓度为0.1 mol%、温度为160℃的条件下,能在短时间内生成PCL较高的数平均分子量(mn = 9.0 × 104 g/mol)和%收率(89%)。通过配位插入机理,提出了ε-CL与Sn(Oct)2/n-HexOH的ROP机理。
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引用次数: 6
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