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Preparation and properties of Pue-loaded HA-ADH-PS nanomicelles. pue负载HA-ADH-PS纳米胶束的制备及性能研究。
IF 1.6 4区 化学 Q3 POLYMER SCIENCE Pub Date : 2021-01-17 DOI: 10.1080/15685551.2020.1860481
Huiru Wang, Yuanyuan Li, Yunpeng Min, Hang Zhang, Linkun Hao, Ru Zhang, Yunying Jiang, Yimin Song

Puerarin (Pue) is the most abundant isoflavonoid in kudzu root. It has been widely used as a therapeutic agent for the treatment of cardiovascular diseases. However, poor-bioavailability of puerarin is the main obstacle to its widespread clinical applications. In this paper, HA-ADH-PS nanomicelles were prepared by chemical modification, noncovalent modification and etc, and characterized by means of FT-IR, ultraviolet (UV) and thermogravimetric analysis (TG). The encapsulation efficiency and drug loading of Pue-loaded HA-ADH-PS nanomicelles were 45.1% and 19.89% by UV, respectively. It could be observed from the transmission electron microscopy (TEM) images that HA-ADH-PS micelles appeared obvious spherical structure in the water. The particle size of HA-ADH-PS nanomicelles and Pue-loaded HA-ADH-PS nanomicelles were about 136.8 nm and 119.5 nm with a PDI of 0.237 and 0.272, respectively. The fluorescence probe method was used to characterize the critical micelle concentration, the critical micelle concentration (CMC) value of the nanomicells was 0.002 g/L and the results met the requirements and ensured the stability of micelles after dilution. DPPH assay suggested that Pue-loaded HA-ADH-PS nanomicelles had an obvious radical scavenging effect in vitro. MTT test showed that Pue-loaded HA-ADH-PS nanomicelles was non-toxic and had good biocompatibility. Thus, Pue-loaded HA-ADH-PS nanomicelles could be used as a potential drug carrier for puerarin.

葛根素(Pue)是葛根中含量最多的异黄酮。它已被广泛用作治疗心血管疾病的治疗剂。然而,葛根素的生物利用度差是其广泛应用于临床的主要障碍。本文通过化学改性、非共价改性等方法制备了HA-ADH-PS纳米胶束,并用红外光谱(FT-IR)、紫外(UV)和热重分析(TG)对其进行了表征。紫外检测结果表明,pue负载的HA-ADH-PS纳米胶束包封率和载药量分别为45.1%和19.89%。透射电镜(TEM)观察到HA-ADH-PS胶束在水中呈现明显的球形结构。HA-ADH-PS和pue负载的HA-ADH-PS纳米胶束粒径分别为136.8 nm和119.5 nm, PDI分别为0.237和0.272。采用荧光探针法对临界胶束浓度进行表征,纳米细胞的临界胶束浓度(CMC)值为0.002 g/L,结果满足要求,并保证了稀释后胶束的稳定性。DPPH实验表明,负载pue的HA-ADH-PS纳米胶束具有明显的体外自由基清除作用。MTT试验表明,负载pue的HA-ADH-PS纳米胶束无毒且具有良好的生物相容性。因此,pue负载HA-ADH-PS纳米胶束可作为葛根素的潜在药物载体。
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引用次数: 3
Thermal stability enhancement of poly(hydroxybutyrate-co-hydroxyvalerate) through in situ reaction 原位反应增强聚羟基丁酸酯-羟基戊酸酯的热稳定性
IF 1.6 4区 化学 Q3 POLYMER SCIENCE Pub Date : 2021-01-01 DOI: 10.1080/15685551.2021.1914406
Pongsakorn Nuchanong, M. Seadan, R. Khankrua, S. Suttiruengwong
ABSTRACT Poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV) has recently caught more and more attention due to its renewability, good mechanical and barrier properties, as well as marine biodegradability. However, the severe thermal degradation during processing is a major drawback and limits its application. In this work, the thermal stability of PHBV during melt-processing was investigated by incorporating reactive agents. Various contents of Di(tert-butylperoxyisopropyl)benzene (DB), Triallyl isocyanurate (TAIC) and multi-functional epoxy chain extender (ECE) were used. The mixing torque, mechanical and thermal properties were studied. The results revealed that the mixing torque of PHBV gradually decreased during 10 min of melting time and eventually dropped to 2 N.m. Upon adding ECE, the mixing torque slightly increased but still decreased during 10 min period. For the system consisting of DB/TAIC or DB/TAIC/ECE, the mixing torque reached the equilibrium and their values were roughly twofold higher than PHBV alone. The possible crosslinking reaction and torque reversion were predominantly observed when adding high contents of DB and TAIC. 1 H NMR spectra suggested the reaction of DB/TAIC and PHBV. Young’s modulus and tensile strength of system consisting of DB at 0.3 phr, TAIC at 0.1 phr and ECE at 0.5 phr increased from 1440 and 40.4 MPa to 1803 and 55.5 MPa, respectively. TGA thermograms showed that the onset temperature and inflection point were improved when adding DB/TAIC and ECE. From the findings, it indicated that the combination of DB/TAIC and ECE was one of the simplest and effective ways to improve the melt viscosity without sacrificing the mechanical properties.
摘要聚羟基丁酸酯-共羟基戊酸酯(PHBV)由于其可再生性、良好的机械性能和阻隔性能以及海洋生物降解性,近年来受到越来越多的关注。然而,加工过程中的严重热降解是一个主要缺点,并限制了其应用。在这项工作中,通过加入反应剂,研究了PHBV在熔融加工过程中的热稳定性。使用不同含量的过氧化异丙基二(叔丁基)苯(DB)、异氰脲酸酯三烯丙基酯(TAIC)和多功能环氧扩链剂(ECE)。研究了混合转矩、机械性能和热性能。结果表明,PHBV的混合转矩在10分钟的熔融时间内逐渐降低,最终降至2 N.m。加入ECE后,混合转矩略有增加,但在10分钟内仍有所下降。对于由DB/TAIC或DB/TAIC/ECE组成的系统,混合转矩达到平衡,并且它们的值比单独的PHBV高大约两倍。当添加高含量的DB和TAIC时,主要观察到可能的交联反应和扭矩逆转。1H NMR谱表明DB/TAIC与PHBV反应。由0.3份的DB、0.1份的TAIC和0.5份的ECE组成的体系的杨氏模量和拉伸强度分别从1440和40.4MPa提高到1803和55.5MPa。TGA热谱图显示,添加DB/TAIC和ECE可改善起始温度和拐点。研究结果表明,DB/TAIC和ECE的结合是在不牺牲力学性能的情况下提高熔体粘度的最简单有效的方法之一。
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引用次数: 4
Construction of poly(ethylene glycol)-poly(L-lactic acid)-stearic acid reverse aspirin-loaded micelles and optimization of preparation process. 聚乙二醇-聚l -乳酸-硬脂酸逆负载阿司匹林胶束的构建及制备工艺优化
IF 1.6 4区 化学 Q3 POLYMER SCIENCE Pub Date : 2020-11-23 DOI: 10.1080/15685551.2020.1845428
Yunpeng Min, Hang Zhang, Huiru Wang, Yimin Song

This work aims to study the construction of reverse aspirin-loaded micelles prepared from amphiphilic PEG-PLA-SA triblock copolymers and the optimization of the preparation process. Using polyethylene glycol (PEG) as the initiator, ring-opening polymerization of L-lactide (L-LA) was used to prepare PEG-PLA diblock copolymers. Final product PEG-PLA-SA triblock copolymers were prepared by the reaction of stearic acid (SA) and PEG-PLA catalyzed by 4-dimethylaminopyridine (DMAP) and N,N'-Dicyclohexylcarbodiimide (DCC). Fourier transform infrared spectrometer (FT-IR) was used to characterize the product structure. PEG-PLA-SA triblock copolymers self-assembled in toluene/ethanol/water system to form reverse micelles, which could encapsulate aspirin into a hydrophilic core. Dynamic light scattering (DLS) and transmission electron microscopy (TEM) were used to determine the size and morphology of reverse micelles. The results showed that the reverse micelles are spherical, with a particle size of less than 70 nm. Response surface analysis method was applied to optimize the preparation process of PEG-PLA-SA. In vitro drug release was achieved by embedding reverse aspirin-loaded micelles in the biocompatible membrane in phosphate buffer saline (PBS) at 37°C. In the first 8 h, the drug release rate of the triblock copolymers was slower than that of the diblock copolymers. After 8 h, the drug release rate of both tended to be flat. The stability of aspirin-loaded reverse micelles was studied through accelerated test. These results indicate that reverse micelle PEG-PLA-SA may be a promising carrier for hydrophilic drugs like aspirin.

本工作旨在研究两亲性PEG-PLA-SA三嵌段共聚物反负载阿司匹林胶束的构建及制备工艺的优化。以聚乙二醇(PEG)为引发剂,采用l -丙交酯(L-LA)开环聚合法制备了PEG- pla二嵌段共聚物。以硬脂酸(SA)为原料,以4-二甲氨基吡啶(DMAP)和N,N'-双环己基碳二酰亚胺(DCC)为催化剂,与PEG-PLA反应制备最终产物PEG-PLA-SA三嵌段共聚物。利用傅里叶变换红外光谱仪(FT-IR)对产物结构进行表征。PEG-PLA-SA三嵌段共聚物在甲苯/乙醇/水体系中自组装形成反胶束,可将阿司匹林包裹成亲水性核。采用动态光散射(DLS)和透射电子显微镜(TEM)测定了反胶束的大小和形态。结果表明:反胶束呈球形,粒径小于70 nm;采用响应面分析法对PEG-PLA-SA的制备工艺进行优化。在37°C的磷酸盐缓冲盐水(PBS)中,在生物相容性膜中包埋反向负载阿司匹林胶束,实现体外药物释放。在前8 h,三嵌段共聚物的药物释放速度比二嵌段共聚物慢。8 h后,两种药物的释放速度趋于平缓。通过加速实验研究了阿司匹林反胶束的稳定性。这些结果表明,反胶束PEG-PLA-SA可能是一种很有前途的亲水药物载体,如阿司匹林。
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引用次数: 2
Preparation of amphiphilic magnetic polyvinyl alcohol targeted drug carrier and drug delivery research. 两亲性磁性聚乙烯醇靶向药物载体的制备及给药研究。
IF 1.6 4区 化学 Q3 POLYMER SCIENCE Pub Date : 2020-10-23 DOI: 10.1080/15685551.2020.1837442
Yazhen Wang, Zhen Shi, Yu Sun, Xueying Wu, Shuang Li, Shaobo Dong, Tianyu Lan

Currently, magnetic applications have great potential for development in the field of drug carriers. In this paper, Fe3O4-PVA@SH, an amphiphilic magnetically targeting drug carrier, was prepared by using Fe3O4 and PVA with thiohydrazide-iminopropyltriethoxysilane(TIPTS). The loading capacity of Fe3O4-PVA@SH on Aspirin and the drug release kinetics of loaded drugs were studied. The obtained Fe3O4-PVA@SH exhibits excellent drug release properties in simulating the human body fluid environment (pH 7.2). Since magnetically targeting drug carriers are readily available and have excellent biocompatibility and the characteristics of drug release. This work's development, preparing amphiphilic magnetically targeting drug carriers in drug delivery and other fields, has great significance.

目前,磁性材料在药物载体领域具有很大的发展潜力。本文以Fe3O4和PVA为原料,用硫酰肼-亚氨基丙基三乙氧基硅烷(TIPTS)制备了两亲性磁靶向药物载体Fe3O4-PVA@SH。研究了Fe3O4-PVA@SH对阿司匹林的负载能力和负载药物的释放动力学。所得Fe3O4-PVA@SH在模拟人体体液环境(pH 7.2)中表现出优异的药物释放性能。由于磁性靶向药物载体易于获得,具有良好的生物相容性和药物释放特性。本工作的开展,对制备两亲性磁性靶向药物载体在药物递送等领域具有重要意义。
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引用次数: 7
Correction. 修正。
IF 1.6 4区 化学 Q3 POLYMER SCIENCE Pub Date : 2020-10-07 DOI: 10.1080/15685551.2020.1827621

[This corrects the article DOI: 10.1080/15685551.2017.1314654.].

[这更正了文章DOI: 10.1080/15685551.2017.1314654.]。
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引用次数: 0
Effect of boric acid on poly vinyl alcohol- tannin blend and its application as water-based wood adhesive. 硼酸对聚乙烯醇-单宁共混物的影响及其作为水性木材胶粘剂的应用。
IF 1.6 4区 化学 Q3 POLYMER SCIENCE Pub Date : 2020-10-05 DOI: 10.1080/15685551.2020.1826124
Ravindra V Gadhave, Vineeth S K, Pritam V Dhawale, Pradeep T Gadekar

The work presented here focusses on developing adhesive by blending tannin and polyvinyl alcohol (PVA) in water. To furthermore enhance the properties crosslinking is carried by using boric acid at varying concentrations. Presence of free hydroxyl groups in PVA and tannin acts as a site for crosslinking reaction. The empty p orbital of trivalent boron atom attracts nucleophilic hydroxyl groups of PVA and tannin, hence are expected to form crosslinks. The interaction of boric acid with the blend was confirmed by FTIR spectra studies. The acidic pH favoured the reaction and its effects were observed by increase in viscosity and glass transition temperature (Tg). Films cased with the crosslinked blend demonstrated less hydrophilic behaviour from water contact angle test also increment in pencil hardness value and stress-bearing capacity. Adhesive performance properties like wet tack and time-dependent tensile lap shear strength on softwood and hardwood specimens were evaluated. The crosslinking-enhanced cohesion by reducing the free volumes between the chains and due to this, enhancement in tensile strength on bonded wood substrates was observed. Overall, it was found that the adhesive prepared by crosslinking PVA/tannin blend with boric acid is suitable for wood adhesive application.

本文介绍了用单宁和聚乙烯醇(PVA)在水中混合制备胶粘剂的研究。为了进一步提高性能,用不同浓度的硼酸进行交联。PVA和单宁中游离羟基的存在为交联反应提供了场所。三价硼原子的空p轨道吸引PVA和单宁的亲核羟基,因此有望形成交联。红外光谱研究证实了硼酸与共混物的相互作用。酸性pH有利于反应,其影响通过粘度和玻璃化转变温度(Tg)的增加来观察。在水接触角测试中,交联共混物薄膜的亲水性降低,铅笔硬度值和应力承载能力也有所增加。粘接性能,如湿粘性和时间相关的拉伸搭接剪切强度在软木和硬木样品进行了评估。通过减少链之间的自由体积,交联增强了内聚性,因此,观察到粘合木材基材的抗拉强度增强。结果表明,硼酸与PVA/单宁共混交联制备的胶粘剂适用于木材胶粘剂。
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引用次数: 17
Synthesis, characterization and properties of novel polyamides derived from 4 4' bis(4-carboxy methylene) biphenyl and various diamines. 以4- 4′双(4-羧基亚甲基)联苯和各种二胺为原料的新型聚酰胺的合成、表征和性能。
IF 1.6 4区 化学 Q3 POLYMER SCIENCE Pub Date : 2020-09-30 DOI: 10.1080/15685551.2020.1826705
Shivaji D Ghodke, Aslam B Tamboli, Arati V Diwate, Vijay P Ubale, Noormahmad N Maldar

Novel aromatic aliphatic diacid monomer, 4 4' bis(4-carboxy methylene) biphenyl was synthesized via friedel craft acylation with acetic anhydride followed by willgerodot reaction and used in the preparation of polyamides by direct polycondensation using the Yamazaki phosphorylation reaction with commercial aromatic diamines. These polyamides were obtained in good yield with moderate-to-high-molecular-weight build up as evidenced by inherent viscosities in the range of 0.52-0.96 dlg-1. The XRD studies showed that all the polyamides were amorphous in nature and these polymers dissolved in polar aprotic solvents such as N-methyl-2-pyrrolidone(NMP),N,N-dimethylsulfoxide(DMSO), N,N-dimethyl formamide (DMF) and N,N-dimethyl acetamide. The resulting polyamides were characterized by inherent viscocity measurements, FT-IR, 1H NMR and 13C NMR spectroscopy, solubility, thermogravimetry, X-ray diffraction studies. These polyamides had glass transition temperatures between 210°C and 261°C, and their temperatures at a 10% weight loss were 620 to 710°C and 497 to 597°C in nitrogen and air atmospheres, respectively, which indicates thermally stable polymers.

摘要以乙酸酐为原料,经friedel工艺酰化反应合成了新型芳香族脂肪族二酸单体——4- 4′双(4-羧基亚甲基)联苯,并与商品芳香族二胺采用山崎磷酸化反应直接缩聚制备了聚酰胺。这些聚酰胺的产率高,分子量增加,固有粘度在0.52-0.96 dlg-1之间。XRD研究表明,所有聚酰胺均为无定形,可溶于N-甲基-2-吡罗烷酮(NMP)、N,N-二甲基亚砜(DMSO)、N,N-二甲基甲酰胺(DMF)和N,N-二甲基乙酰胺等极性非质子溶剂中。所得聚酰胺通过固有粘度测量、FT-IR、1H NMR和13C NMR、溶解度、热重、x射线衍射研究进行了表征。这些聚酰胺的玻璃化转变温度在210 ~ 261℃之间,失重10%时在氮气和空气环境中的温度分别为620 ~ 710℃和497 ~ 597℃,表明它们是热稳定的聚合物。
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引用次数: 2
The study on microstructure and mechanical properties of multi-component composite based on HDPE. 基于HDPE的多组分复合材料的微观结构和力学性能研究。
IF 1.6 4区 化学 Q3 POLYMER SCIENCE Pub Date : 2020-09-18 DOI: 10.1080/15685551.2020.1818956
Yazhen Wang, Chenglong Wang, Shaobo Dong, Liwu Zu, Tianyu Lan

The basalt fiber (BF) and polyamide 6 (PA6) reinforced HDPE composite were prepared; the effects of adding fiber, organic filler, and polar component maleic anhydride (MA) on the microstructural characteristics of composites were investigated. Microstructural characterization evidenced the binary-dispersed phase (PA6/BF) is of a core-shell structure in which the component PA6 encapsulates component BF, and the extent of encapsulates would decline with the MA adding. It is confirmed that the microstructure is related to the interfacial tension of components by the SEM observation and theoretical calculation. The effect of multi-component on the crystallization behavior of composites was investigated. Differential scanning calorimeter (DSC) analyses showed a significant change in the HDPE microstructure. It demonstrated PA6 and BF as a nucleation agent accelerated the crystallization rate under the cooling process. The corresponding crystallization kinetics and activation energy were further analyzed using the Jeziorny method, Avrami-Ozawa method, Kissinger method. The results showed MA markedly changed the crystal growth mechanism of the HDPE matrix to heterogeneous nucleation for acicular and tabular crystal growth during the annealing step. The lowest crystallinity energy and crystallinity were observed for BF/PA6/HDPE composites with 3 wt % MA. Furthermore, a clear improvement of mechanical properties (by 61%) were observed, which mechanism is discussed in detail. The mechanism of toughening is not only one, but the result of a variety of mechanisms together.

制备了玄武岩纤维(BF)和聚酰胺6 (PA6)增强HDPE复合材料;研究了纤维、有机填料和极性组分马来酸酐(MA)的加入对复合材料微观组织特性的影响。微观结构表征表明,双分散相(PA6/BF)为核壳结构,组分PA6包覆组分BF,包覆程度随MA的加入而减小。通过SEM观察和理论计算,证实了其微观结构与构件的界面张力有关。研究了多组分对复合材料结晶行为的影响。差示扫描量热仪(DSC)分析显示HDPE微观结构发生了显著变化。结果表明,PA6和BF作为成核剂,在冷却过程中加速了结晶速度。采用Jeziorny法、Avrami-Ozawa法和Kissinger法分析了结晶动力学和活化能。结果表明,在退火过程中,MA显著改变了HDPE基体的晶体生长机制,使其向非均质成核方向生长,形成针状和板状晶体。当MA含量为3 wt %时,BF/PA6/HDPE复合材料的结晶度和结晶度最低。此外,观察到力学性能明显改善(61%),并详细讨论了其机理。增韧的机理不是单一的,而是多种机理共同作用的结果。
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引用次数: 3
Design and application of polyurea microcapsules containing herbicide (oxyfluorfen). 含有除草剂(氧氟草醚)的聚脲微胶囊的设计与应用。
IF 1.6 4区 化学 Q3 POLYMER SCIENCE Pub Date : 2020-09-08 DOI: 10.1080/15685551.2020.1816344
Jayprakash Rao, Amar Nath Chandrani, Anil Powar, Sudeshna Chandra

Polyurea, a controlled release material, has been widely applied in agricultural fields due to high thermal stability and low cost. In this article oxyfluorfen polyurea microcapsules suspension was successfully prepared by interfacial polymerization using diisocyanate and polyamines such as Ethylenediamine, Hexamethylenediamine, Diethylenetriamine in presence of green solvent, i.e., N,N-dimethyldecanamide. The microcapsule suspension of oxyfluorfen has not been researched yet by using solvent N,N-dimethyldecanamide and polyamines. The effect and the type of diamines on the morphology and properties of the microcapsules have been investigated. The synthesized microcapsules were characterized by scanning electron microscope, ultraviolet spectrometry, Fourier transform iInfrared spectrometer, thermogravimetric analysis and particle size analyser. The effect of the core to shell ratio on encapsulation efficiency and release kinetics were also studied. The oxyfluorfen microcapsules had an excellent encapsulation efficiency (98.2%) using EDA as the monomer and Release kinetics depended upon the type of monomers used and also on core to shell ratio used (6.5:1, 5:1, 4:1). As core to shell ratio was increased the encapsulation efficiency was found to decrease. Prepared Microcapsules when sprayed on paddy crop was found to be safe in comparison with Emulsifiable concentrate sample.

聚脲是一种控释材料,因其热稳定性高、成本低而被广泛应用于农业领域。本文利用二异氰酸酯和多胺(如乙二胺、六亚甲基二胺、二乙烯三胺)在绿色溶剂(即 N,N-二甲基癸酰胺)存在下进行界面聚合,成功制备了氧氟草酯聚脲微胶囊悬浮液。目前还没有使用 N,N-二甲基癸酰胺和多胺来研究氧氟草醚的微胶囊悬浮剂。我们研究了二元胺的类型对微胶囊形态和性能的影响。通过扫描电子显微镜、紫外光谱仪、傅立叶变换红外光谱仪、热重分析和粒度分析仪对合成的微胶囊进行了表征。此外,还研究了芯壳比对封装效率和释放动力学的影响。以 EDA 为单体的氧氟草醚微胶囊具有极佳的封装效率(98.2%),释放动力学取决于所用单体的类型以及芯壳比(6.5:1、5:1、4:1)。随着芯壳比的增加,封装效率会降低。与乳油样品相比,制备的微胶囊喷洒在水稻作物上是安全的。
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引用次数: 0
Synthesis, conjugating capacity and biocompatibility evaluation of a novel amphiphilic polynorbornene. 新型两亲性聚降冰片烯的合成、偶联性能及生物相容性评价。
IF 1.6 4区 化学 Q3 POLYMER SCIENCE Pub Date : 2020-08-30 DOI: 10.1080/15685551.2020.1812832
Hengxi He, Bin Song, Guirong Qiu, Weixiang Wang, Haibin Gu

Polynorbornenes, prepared by the 'living' and 'controlled' ring-opening metathesis polymerization (ROMP) method, have emerged as a stimuli-sensitive new class of polymer carriers. Herein, we reported a novel amphiphilic diblock polynorbornene, PNCHO-b-PNTEG, containing active benzaldehyde units, which exhibited good conjugating capacity to amino-containing molecules (e.g., doxorubicin (DOX)) via the pH-sensitive Schiff base linkage. The copolymer and its conjugate with DOX, DOX-PNCHO-b-PNTEG, were adequately analyzed by various techniques including 1H NMR, 13C NMR, gel permeation chromatography, etc. Especially, the formed conjugate of DOX-PNCHO-b-PNTEG could self-assemble into near-spherical micelles with the diameter of 81 ± 10 nm, and exhibit acid-triggered DOX release behavior, and the release rate could be adjusted by changing the environmental pH value. The excellent biological safety of PNCHO-b-PNTEG was further demonstrated by the results from both in vitro toxicity evaluation to murine fibroblast cells (L-929 cells) and in vivo evaluation of acute developmental toxicity and cell death in zebrafish embryos. Hence, the present polynorbornene-based PNCHO-b-PNTEG possesses great potential application as a biocompatible polymeric carrier and could be employed to fabricate various pH-sensitive conjugates.

聚降冰片烯是一种对刺激敏感的新型聚合物载体,是通过“活的”和“可控的”开环复分解聚合(ROMP)法制备的。本文中,我们报道了一种新的两亲性二嵌段聚降冰片烯PNCHO-b-PNTEG,它含有活性苯甲醛单元,通过ph敏感的希夫碱键与含氨基分子(如阿霉素(DOX))表现出良好的偶联能力。通过1H NMR、13C NMR、凝胶渗透色谱等多种技术对DOX- pncho -b- pnteg共聚物及其与DOX的共轭物进行了充分的分析。特别是形成的DOX- pncho -b- pnteg缀合物可以自组装成直径为81±10 nm的近球形胶束,并表现出酸触发DOX释放行为,且释放速率可以通过改变环境pH值来调节。PNCHO-b-PNTEG对小鼠成纤维细胞(L-929细胞)的体外毒性评价和斑马鱼胚胎急性发育毒性和细胞死亡的体内毒性评价结果进一步证明了PNCHO-b-PNTEG良好的生物安全性。因此,该聚降冰片烯基PNCHO-b-PNTEG作为一种生物相容性聚合物载体具有很大的应用潜力,可用于制备各种ph敏感偶联物。
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引用次数: 3
期刊
Designed Monomers and Polymers
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