Pub Date : 2021-06-21DOI: 10.1080/15685551.2021.1935014
Juan Li
The preparation of liquid fluoroelastomers that are liquid with excellent mechanical properties remains a challenge. Here, we show a very straightforward method to produce liquid fluoroelastomers by introducing carborane. Carborane-terminated liquid fluoropolymer was synthesized by Steglich reaction of carboxyl-terminated liquid fluoropolymer and 1,7-bis (hydroxy)-carborane. The product is brown, viscous at room temperature and in the semi-solid state. On this basis, HDI Trimer was used as a curing agent to cure liquid fluoroelastomer. Thermogravimetric analysis of the cured products was carried out. The carbon residue rate of the cured product increased from 35% to 58% of the cured product. The results show that the addition of carborane structure can effectively improve the carbon residue rate of liquid fluoroelastomer. The tensile strength, elongation and shore hardness of the cured product were also examined, and the results show that the tensile strength of carborane modified liquid fluorine increased by 463% compared with that before modification, but the elongation at break was reduced by 42%, which was mainly due to the introduction of rigid structure of carborane. At the same time, the solvent resistance test results show that the introduction of carborane structure has little effect on the aviation kerosene resistance and organic solvent resistance of fluororubber, but it can improve its alkali resistance.
{"title":"Preparation and Characterization of Carborane Modified Liquid Fluoroelastomers and the investigation of their properties.","authors":"Juan Li","doi":"10.1080/15685551.2021.1935014","DOIUrl":"https://doi.org/10.1080/15685551.2021.1935014","url":null,"abstract":"<p><p>The preparation of liquid fluoroelastomers that are liquid with excellent mechanical properties remains a challenge. Here, we show a very straightforward method to produce liquid fluoroelastomers by introducing carborane. Carborane-terminated liquid fluoropolymer was synthesized by Steglich reaction of carboxyl-terminated liquid fluoropolymer and 1,7-bis (hydroxy)-carborane. The product is brown, viscous at room temperature and in the semi-solid state. On this basis, HDI Trimer was used as a curing agent to cure liquid fluoroelastomer. Thermogravimetric analysis of the cured products was carried out. The carbon residue rate of the cured product increased from 35% to 58% of the cured product. The results show that the addition of carborane structure can effectively improve the carbon residue rate of liquid fluoroelastomer. The tensile strength, elongation and shore hardness of the cured product were also examined, and the results show that the tensile strength of carborane modified liquid fluorine increased by 463% compared with that before modification, but the elongation at break was reduced by 42%, which was mainly due to the introduction of rigid structure of carborane. At the same time, the solvent resistance test results show that the introduction of carborane structure has little effect on the aviation kerosene resistance and organic solvent resistance of fluororubber, but it can improve its alkali resistance.</p>","PeriodicalId":11170,"journal":{"name":"Designed Monomers and Polymers","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2021-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/15685551.2021.1935014","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39139420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-31DOI: 10.1080/15685551.2021.1935010
Yan Hu, Jiao Ni
A new Cd(II) coordination polymer with the formula of {[(CH3)2NH2][Cd3(NH2-bdc)3(btz)(H2O)]} n (1 NH2-H2bdc = 2-aminoterephthalic acid, Hbtz = 1 H-benzotriazole) was produced and then it was structurally characterized through powder X-ray diffraction (PXRD), the analysis of X-ray single-crystal diffraction, along with elemental analysis (EA). The photocatalytic property investigations indicate that compound 1 exhibits good activity for photodegradation of methyl violet (MV) with 60.7% of MV removal in 40 min under room temperature. Furthermore, the assessment of the compound's treatment activity and nursing application values on the bacterial infection was conducted and its corresponding mechanism was also studied. Evaluation of the in vitro hemolysis of the compound was determined by measuring the degree of red blood cell lysis and hemoglobin release. The effect of new compounds on the relative proliferation rate of L-929 cells was measured by MTT assay. The ELISA detection kit showed that the compound could reduce the TNF-α and IL-1β content released into plasma. Next, the inhibitory activity of the compound on the bacterial survival gene expression was also proved with real-time RT-PCR. The hemolysis rate of the new compound to blood is 3.4%, which is less than the standard 5%, which is non-hemolytic reaction. The compound also has no obvious cytotoxicity and has good cell compatibility.
{"title":"A new trinuclear cluster-based Cd(II) compound: photocatalytic property and nursing application values on the bacterial infection.","authors":"Yan Hu, Jiao Ni","doi":"10.1080/15685551.2021.1935010","DOIUrl":"10.1080/15685551.2021.1935010","url":null,"abstract":"<p><p>A new Cd(II) coordination polymer with the formula of {[(CH<sub>3</sub>)<sub>2</sub>NH<sub>2</sub>][Cd<sub>3</sub>(NH<sub>2</sub>-bdc)<sub>3</sub>(btz)(H<sub>2</sub>O)]} <sub><i>n</i></sub> (<b>1</b> NH<sub>2</sub>-H<sub>2</sub>bdc = 2-aminoterephthalic acid, Hbtz = 1 H-benzotriazole) was produced and then it was structurally characterized through powder X-ray diffraction (PXRD), the analysis of X-ray single-crystal diffraction, along with elemental analysis (EA). The photocatalytic property investigations indicate that compound <b>1</b> exhibits good activity for photodegradation of methyl violet (MV) with 60.7% of MV removal in 40 min under room temperature. Furthermore, the assessment of the compound's treatment activity and nursing application values on the bacterial infection was conducted and its corresponding mechanism was also studied. Evaluation of the in vitro hemolysis of the compound was determined by measuring the degree of red blood cell lysis and hemoglobin release. The effect of new compounds on the relative proliferation rate of L-929 cells was measured by MTT assay. The ELISA detection kit showed that the compound could reduce the TNF-α and IL-1β content released into plasma. Next, the inhibitory activity of the compound on the bacterial survival gene expression was also proved with real-time RT-PCR. The hemolysis rate of the new compound to blood is 3.4%, which is less than the standard 5%, which is non-hemolytic reaction. The compound also has no obvious cytotoxicity and has good cell compatibility.</p>","PeriodicalId":11170,"journal":{"name":"Designed Monomers and Polymers","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2021-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168771/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39074070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-25DOI: 10.1080/15685551.2021.1930670
Que Kong, Zhiguang Li, Xuehong Ren, Hao Gu, Wujun Ma
Electrospinning provides a versatile, efficient and low-cost method for the preparation of continuous nanofibres from various polymers. In this study, the polyhedral oligomeric silsesquioxanes (POSS) block copolymer was synthesized via atom transfer radical polymerization. The smooth fiber, porous fiber or hierarchically porous microspheres were prepared by electrospinning from POSS block copolymer, poly(vinylidene fluoride) (PVDF) and aluminium oxide (Al2O3). The influence of copolymer concentration, the ratio of the solvents, the diameter and concentration of the Al2O3 on the surface morphology were investigated. Porous fibers and porous microspheres were prepared by regulating the ratio of the solvents from the phase separation and breath figure methods. The dynamic behavior of the water droplet with the constant volume impacting on the electrospinning films were reported. The morphology evolution, restitution coefficient, the change of energy of the water droplets are examined. The droplet bounces several times on the superhydrophobic surface, while the droplet remains pinned and does not rebound when the contact angles was lower than 150°. On the other hand, the water droplets were splashed on the Al2O3 based electrospinning films. Finally, the mechanical properties of the electrospinning films were investigated.
{"title":"The surface morphology and dynamic impact properties with rebounding and splashing of water droplet on phase separation and breath figure assisted electrospinning films.","authors":"Que Kong, Zhiguang Li, Xuehong Ren, Hao Gu, Wujun Ma","doi":"10.1080/15685551.2021.1930670","DOIUrl":"https://doi.org/10.1080/15685551.2021.1930670","url":null,"abstract":"<p><p>Electrospinning provides a versatile, efficient and low-cost method for the preparation of continuous nanofibres from various polymers. In this study, the polyhedral oligomeric silsesquioxanes (POSS) block copolymer was synthesized via atom transfer radical polymerization. The smooth fiber, porous fiber or hierarchically porous microspheres were prepared by electrospinning from POSS block copolymer, poly(vinylidene fluoride) (PVDF) and aluminium oxide (Al<sub>2</sub>O<sub>3</sub>). The influence of copolymer concentration, the ratio of the solvents, the diameter and concentration of the Al<sub>2</sub>O<sub>3</sub> on the surface morphology were investigated. Porous fibers and porous microspheres were prepared by regulating the ratio of the solvents from the phase separation and breath figure methods. The dynamic behavior of the water droplet with the constant volume impacting on the electrospinning films were reported. The morphology evolution, restitution coefficient, the change of energy of the water droplets are examined. The droplet bounces several times on the superhydrophobic surface, while the droplet remains pinned and does not rebound when the contact angles was lower than 150°. On the other hand, the water droplets were splashed on the Al<sub>2</sub>O<sub>3</sub> based electrospinning films. Finally, the mechanical properties of the electrospinning films were investigated.</p>","PeriodicalId":11170,"journal":{"name":"Designed Monomers and Polymers","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2021-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/15685551.2021.1930670","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39074069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-18DOI: 10.1080/15685551.2021.1929684
Hongmei Bi, Zeqin Chen, Jiaqin Qiu
Magnetic nanoparticles (MNPs) with safety, stability and excellent magneto-calorific effect are the precondition for the smart magnetic drug carriers' fabrication and controllable drug release at a specific target in clinical treatment. In this study, the drug release and magneto-calorific effect of two types of magnetic lipid microcapsules (MLMs) loading lipid-coated MNPs and uncoated MNPs respectively were compared deeply in experimental analysis and theoretical simulation. The simulation results revealed that almost same magnetic heat effect and temperature increasing exist between lipid-coated and uncoated MNPs, which was consistent with the experimental drug release results. Coating lipid on MNPs didn't affect the magnetic heat and heat transfer of the MNPs. Because of the heat transfer between MNPs and water, MLMs and water around, the temperature increasing of whole sample solution is lower than that of the MNPs themselves. Our results provide a reliable theoretical basis for the development of healthy, safe, and biocompatible drug delivery systems.
{"title":"Drug release and magneto-calorific analysis of magnetic lipid microcapsules for potential cancer therapeutics.","authors":"Hongmei Bi, Zeqin Chen, Jiaqin Qiu","doi":"10.1080/15685551.2021.1929684","DOIUrl":"https://doi.org/10.1080/15685551.2021.1929684","url":null,"abstract":"<p><p>Magnetic nanoparticles (MNPs) with safety, stability and excellent magneto-calorific effect are the precondition for the smart magnetic drug carriers' fabrication and controllable drug release at a specific target in clinical treatment. In this study, the drug release and magneto-calorific effect of two types of magnetic lipid microcapsules (MLMs) loading lipid-coated MNPs and uncoated MNPs respectively were compared deeply in experimental analysis and theoretical simulation. The simulation results revealed that almost same magnetic heat effect and temperature increasing exist between lipid-coated and uncoated MNPs, which was consistent with the experimental drug release results. Coating lipid on MNPs didn't affect the magnetic heat and heat transfer of the MNPs. Because of the heat transfer between MNPs and water, MLMs and water around, the temperature increasing of whole sample solution is lower than that of the MNPs themselves. Our results provide a reliable theoretical basis for the development of healthy, safe, and biocompatible drug delivery systems.</p>","PeriodicalId":11170,"journal":{"name":"Designed Monomers and Polymers","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2021-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/15685551.2021.1929684","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39074068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-07DOI: 10.1080/15685551.2021.1921341
Chen-Lu Jin, Shao-Jun Fang, Li Yu, Zhen-Shan Guo
A Cu(II) coordination polymer with the composition of [Cu2(L)2(4,4'-bipy)2]n·2 n(ClO4) (1, HL = 4-methyl-L-phenylalanine and 4,4'-bipy is 4,4'-bipyridine), was successfully obtained by the reaction of the mixed ligand of HL and 4,4'-bipy with Cu(ClO4)2 · 6H2O under solvothermal condition. The as-synthesized compound not only has high thermal stability until 275°C but also excellent photocatalytic activity for the methyl blue solution degradation under the irradiation of ultraviolet light. Furthermore, the compound's treatment activity on the diabetes was determined and its relevant mechanism was also studied. The cytotoxicity or hemolysis toxicity (HC50) of the synthesized compound was also evaluated in this research.
{"title":"A new thermostable Cu(II) coordination polymer: photocatalytic activity and application values on diabetes.","authors":"Chen-Lu Jin, Shao-Jun Fang, Li Yu, Zhen-Shan Guo","doi":"10.1080/15685551.2021.1921341","DOIUrl":"https://doi.org/10.1080/15685551.2021.1921341","url":null,"abstract":"<p><p>A Cu(II) coordination polymer with the composition of [Cu<sub>2</sub>(L)<sub>2</sub>(4,4'-bipy)<sub>2</sub>]<sub>n</sub>·2 n(ClO<sub>4</sub>) (<b>1</b>, HL = 4-methyl-L-phenylalanine and 4,4'-bipy is 4,4'-bipyridine), was successfully obtained by the reaction of the mixed ligand of HL and 4,4'-bipy with Cu(ClO<sub>4</sub>)<sub>2</sub> · 6H<sub>2</sub>O under solvothermal condition. The as-synthesized compound not only has high thermal stability until 275°C but also excellent photocatalytic activity for the methyl blue solution degradation under the irradiation of ultraviolet light. Furthermore, the compound's treatment activity on the diabetes was determined and its relevant mechanism was also studied. The cytotoxicity or hemolysis toxicity (HC50) of the synthesized compound was also evaluated in this research.</p>","PeriodicalId":11170,"journal":{"name":"Designed Monomers and Polymers","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2021-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/15685551.2021.1921341","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39007213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-07DOI: 10.1080/15685551.2021.1924959
Xin Chen, Yuexing Chen, Sengwei Lv, Lingling Zhang, Rulan Ye, Chuchu Ge, Dayun Huang, Sihai Zhang, Zaisheng Cai
A new type of superhydrophobic borneol-based polymeric coating has been prepared. The chemical composition of the polymer particles was analyzed by Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy, which showed that the polymer did not contain fluorine, which can effectively avoid the cytotoxic risk of fluorine. By dynamic light scattering, scanning electron microscopy, and static contact angle measurement, the contact angle of the prepared coating gradually increased with increasing diameter of the polymer particles, and a superhydrophobic coating surface was finally obtained. Interestingly, after dissolving the superhydrophobic sample with tetrahydrofuran and making it a normal hydrophobic sample, the antiadhesion performance for E. coli was greatly reduced, and it could not effectively prevent E. coli adhesion. In addition, a long-term antiadhesion study of bacteria was performed. The superhydrophobic borneol-based polymer coating showed long-term resistance to E. coli adhesion. Therefore, the excellent antibacterial properties and cell compatibility mean that this series of polymer materials has great potential in the field of biomedicine.
{"title":"New type of borneol-based fluorine-free superhydrophobic antibacterial polymeric coating.","authors":"Xin Chen, Yuexing Chen, Sengwei Lv, Lingling Zhang, Rulan Ye, Chuchu Ge, Dayun Huang, Sihai Zhang, Zaisheng Cai","doi":"10.1080/15685551.2021.1924959","DOIUrl":"10.1080/15685551.2021.1924959","url":null,"abstract":"<p><p>A new type of superhydrophobic borneol-based polymeric coating has been prepared. The chemical composition of the polymer particles was analyzed by Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy, which showed that the polymer did not contain fluorine, which can effectively avoid the cytotoxic risk of fluorine. By dynamic light scattering, scanning electron microscopy, and static contact angle measurement, the contact angle of the prepared coating gradually increased with increasing diameter of the polymer particles, and a superhydrophobic coating surface was finally obtained. Interestingly, after dissolving the superhydrophobic sample with tetrahydrofuran and making it a normal hydrophobic sample, the antiadhesion performance for <i>E. coli</i> was greatly reduced, and it could not effectively prevent <i>E. coli</i> adhesion. In addition, a long-term antiadhesion study of bacteria was performed. The superhydrophobic borneol-based polymer coating showed long-term resistance to <i>E. coli</i> adhesion. Therefore, the excellent antibacterial properties and cell compatibility mean that this series of polymer materials has great potential in the field of biomedicine.</p>","PeriodicalId":11170,"journal":{"name":"Designed Monomers and Polymers","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2021-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/15685551.2021.1924959","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39074067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-05DOI: 10.1080/15685551.2021.1921923
Said A H Vuai, Numbury Surendra Babu
Endeavors have been made to construct new donor-acceptor (D-A) monomers utilizing 9 H-carbazole (CB) as electron donors and different electron acceptors. All estimations were finished using DFT and TD-DFT, and B3LYP level with a 6-311 G basis set in the gas and chloroform solvent. The impacts of the distinctive acceptors on the geometry of molecules and optoelectronic properties of these D-A monomers were discussed to dissect the connection connecting the molecular structures and the optoelectronic properties. Likewise, the HOMO - LUMO energies, atomic orbital densities are calculated theoretically. Notwithstanding the charge transfer measure between the carbazole electron donor unit and the electron acceptor one is upheld by breaking down the optical spectra of the acquired monomers and the restriction of involved HOMO and LUMO. The outcomes show that the D-A monomers, CB-ODP, CB-TDP, and CB-SDP, are acceptable for optoelectronic applications in organic solar cells like BHJ.
{"title":"Theoretical design of low bandgap donor-acceptor (D-A) monomers for polymer solar cells: DFT and TD-DFT study.","authors":"Said A H Vuai, Numbury Surendra Babu","doi":"10.1080/15685551.2021.1921923","DOIUrl":"https://doi.org/10.1080/15685551.2021.1921923","url":null,"abstract":"<p><p>Endeavors have been made to construct new donor-acceptor (D-A) monomers utilizing 9 H-carbazole (CB) as electron donors and different electron acceptors. All estimations were finished using DFT and TD-DFT, and B3LYP level with a 6-311 G basis set in the gas and chloroform solvent. The impacts of the distinctive acceptors on the geometry of molecules and optoelectronic properties of these D-A monomers were discussed to dissect the connection connecting the molecular structures and the optoelectronic properties. Likewise, the HOMO - LUMO energies, atomic orbital densities are calculated theoretically. Notwithstanding the charge transfer measure between the carbazole electron donor unit and the electron acceptor one is upheld by breaking down the optical spectra of the acquired monomers and the restriction of involved HOMO and LUMO. The outcomes show that the D-A monomers, CB-ODP, CB-TDP, and CB-SDP, are acceptable for optoelectronic applications in organic solar cells like BHJ.</p>","PeriodicalId":11170,"journal":{"name":"Designed Monomers and Polymers","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2021-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/15685551.2021.1921923","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39007212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-04-22DOI: 10.1080/15685551.2021.1919389
Qipeng Li, Qiuxiang Yin, Baohong Hou, Ling Zhou
Implanted medical devices that have poor friction property or biofilm formation can limit their service life and cause discomfort in patients. Recently, some zwitterionic coatings have been studied to modify the biomaterials surface for lubricating function, but the grafting methods of coatings are complicated and also seldom take the bacterial antiadhesion property into account at the same time. In our studies, motivated by the properties of nature mussels and human articular, we firstly successfully synthesized double adhesion protection of self-adhesive ternary polymer coating and achieved the excellent lubrication and antifouling functionalization of the medical devices surface. In details, the X-ray photoelectron spectroscopy, scanning electron microscope and the water contact angles could characterize the successful modification on the surface of titanium substrate. Additionally, the tribological tests carried out by atomic force microscope verified the ternary polymer could enhance the lubrication property owing to the hydration lubrication mechanism. Meanwhile, it also possessed the bacterial antiadhesion property for the initial 24 h attributed to the hydration repulsive force. We believe that, as a simple and universal preparation method, the ternary polymer could make a great significance for improving the surface function of biomaterials and alleviating patients' discomfort.
{"title":"Bioinspired double self-adhesion coating based on dopamine, coating resin and phosphorylcholine for surface lubrication and antifouling functionalization.","authors":"Qipeng Li, Qiuxiang Yin, Baohong Hou, Ling Zhou","doi":"10.1080/15685551.2021.1919389","DOIUrl":"10.1080/15685551.2021.1919389","url":null,"abstract":"<p><p>Implanted medical devices that have poor friction property or biofilm formation can limit their service life and cause discomfort in patients. Recently, some zwitterionic coatings have been studied to modify the biomaterials surface for lubricating function, but the grafting methods of coatings are complicated and also seldom take the bacterial antiadhesion property into account at the same time. In our studies, motivated by the properties of nature mussels and human articular, we firstly successfully synthesized double adhesion protection of self-adhesive ternary polymer coating and achieved the excellent lubrication and antifouling functionalization of the medical devices surface. In details, the X-ray photoelectron spectroscopy, scanning electron microscope and the water contact angles could characterize the successful modification on the surface of titanium substrate. Additionally, the tribological tests carried out by atomic force microscope verified the ternary polymer could enhance the lubrication property owing to the hydration lubrication mechanism. Meanwhile, it also possessed the bacterial antiadhesion property for the initial 24 h attributed to the hydration repulsive force. We believe that, as a simple and universal preparation method, the ternary polymer could make a great significance for improving the surface function of biomaterials and alleviating patients' discomfort.</p>","PeriodicalId":11170,"journal":{"name":"Designed Monomers and Polymers","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2021-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/15685551.2021.1919389","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38964649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-04-18DOI: 10.1080/15685551.2021.1914398
Linna Yu, Lingping Kong, Junpeng Xie, Wei Wang, Chen Chang, Hongli Che, Mingzhe Liu
Novel monomer, N, N'-bis(acryloyl) cystinamide (NBACA), was designed and synthesized with L-cystine as row material. By using this NBACA both as the monomer and crosslinker, reduction-sensitive nanohydrogel was prepared in ethanol via distillation-precipitation polymerization. The obtained nanohydrogel can provide a relatively hydrophobic environment and hydrogen-bonding sites inside the gel; therefore, it is suitable for loading hydrophobic drug. When paclitaxel that possess poor water-solubility was used as a model drug, the nanohydrogel represented a high drug-loading capacity, and dispersed well in aqueous solutions. Furthermore, the disulfide-group-containing nanohydrogel exhibited good reduction-sensitive drug-release behavior. The nanohydrogel biodegraded rapidly in a reducing environment, and released approximately 80% of the PTX within 24 h. Cytotoxicity assays showed that the PTX-loaded nanohydrogel exhibited high cytotoxicity against MCF-7 breast cancer cells, while blank nanohydrogels displayed a negligible cytotoxicity.
{"title":"Reduction-sensitive N, N'-Bis(acryloyl) cystinamide-polymerized Nanohydrogel as a Potential Nanocarrier for Paclitaxel Delivery.","authors":"Linna Yu, Lingping Kong, Junpeng Xie, Wei Wang, Chen Chang, Hongli Che, Mingzhe Liu","doi":"10.1080/15685551.2021.1914398","DOIUrl":"10.1080/15685551.2021.1914398","url":null,"abstract":"<p><p>Novel monomer, <i>N, N'</i>-bis(acryloyl) cystinamide (NBACA), was designed and synthesized with L-cystine as row material. By using this NBACA both as the monomer and crosslinker, reduction-sensitive nanohydrogel was prepared in ethanol via distillation-precipitation polymerization. The obtained nanohydrogel can provide a relatively hydrophobic environment and hydrogen-bonding sites inside the gel; therefore, it is suitable for loading hydrophobic drug. When paclitaxel that possess poor water-solubility was used as a model drug, the nanohydrogel represented a high drug-loading capacity, and dispersed well in aqueous solutions. Furthermore, the disulfide-group-containing nanohydrogel exhibited good reduction-sensitive drug-release behavior. The nanohydrogel biodegraded rapidly in a reducing environment, and released approximately 80% of the PTX within 24 h. Cytotoxicity assays showed that the PTX-loaded nanohydrogel exhibited high cytotoxicity against MCF-7 breast cancer cells, while blank nanohydrogels displayed a negligible cytotoxicity.</p>","PeriodicalId":11170,"journal":{"name":"Designed Monomers and Polymers","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2021-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d1/78/TDMP_24_1914398.PMC8079002.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38964648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The kinetics of ring-opening polymerization (ROP) of ε-caprolactone (ε-CL) initiated by 1.0, 1.5 and 2.0 mol% of stannous(II) octoate/n-hexanol (Sn(Oct)2/n-HexOH) wase successfully studied by non-isothermal differential scanning calorimetry (DSC) at heating rates of 5, 10, 15 and 20 °C/min. The DSC polymerization kinetic parameters of ε-CL were calculated using differential (Friedman) and integral isoconversional methods (Kissinger-Akahira-Sunose, KAS). The average activation energy (Ea ) values obtained from Friedman and KAS methods were in the range of 64.9-70.5 kJ/mol and 64.9-80.4 kJ/mol, respectively. The values of frequency factor (A) were determined from model fitting method using Avrami-Erofeev reaction model. The average values of A for the ROP of ε-CL initiated by 1.0, 1.5 and 2.0 mol% of Sn(Oct)2/n-HexOH (1:2) were 7.3x107, 2.8x106 and 1.2x106 min-1, respectively. From kinetics studied, the polymerization rate of ε-CL increased with increasing initiator concentration. The performance of Sn(Oct)2/n-HexOH in the synthesis of poly(ε-caprolactone) (PCL) was investigated by bulk polymerization at temperatures of 140, 160 and 180 °C. Sn(Oct)2/n-HexOH (1:2) could produce high number average molecular weight ( = 9.0 × 104 g/mol) and %yield (89%) of PCL in a short period of time at Sn(Oct)2 concentration of 0.1 mol% and temperature of 160°C. The mechanism of the ROP of ε-CL with Sn(Oct)2/n-HexOH was proposed through the coordination-insertion mechanism.
{"title":"Ring-opening polymerization of <i>ε</i>-caprolactone initiated by tin(II) octoate/<i>n</i>-hexanol: DSC isoconversional kinetics analysis and polymer synthesis.","authors":"Winita Punyodom, Wanich Limwanich, Puttinan Meepowpan, Boontharika Thapsukhon","doi":"10.1080/15685551.2021.1908657","DOIUrl":"https://doi.org/10.1080/15685551.2021.1908657","url":null,"abstract":"<p><p>The kinetics of ring-opening polymerization (ROP) of <i>ε</i>-caprolactone (<i>ε</i>-CL) initiated by 1.0, 1.5 and 2.0 mol% of stannous(II) octoate/<i>n</i>-hexanol (Sn(Oct)<sub>2</sub>/<i>n</i>-HexOH) wase successfully studied by non-isothermal differential scanning calorimetry (DSC) at heating rates of 5, 10, 15 and 20 °C/min. The DSC polymerization kinetic parameters of <i>ε</i>-CL were calculated using differential (Friedman) and integral isoconversional methods (Kissinger-Akahira-Sunose, KAS). The average activation energy (<i>E<sub>a</sub></i> ) values obtained from Friedman and KAS methods were in the range of 64.9-70.5 kJ/mol and 64.9-80.4 kJ/mol, respectively. The values of frequency factor (<i>A</i>) were determined from model fitting method using Avrami-Erofeev reaction model. The average values of <i>A</i> for the ROP of <i>ε</i>-CL initiated by 1.0, 1.5 and 2.0 mol% of Sn(Oct)<sub>2</sub>/<i>n</i>-HexOH (1:2) were 7.3x10<sup>7</sup>, 2.8x10<sup>6</sup> and 1.2x10<sup>6</sup> min<sup>-1</sup>, respectively. From kinetics studied, the polymerization rate of <i>ε</i>-CL increased with increasing initiator concentration. The performance of Sn(Oct)<sub>2</sub>/<i>n</i>-HexOH in the synthesis of poly(<i>ε</i>-caprolactone) (PCL) was investigated by bulk polymerization at temperatures of 140, 160 and 180 °C. Sn(Oct)<sub>2</sub>/<i>n</i>-HexOH (1:2) could produce high number average molecular weight ( <math> <mover> <mrow><msub><mi>M</mi> <mrow><mrow><mi>n</mi></mrow> </mrow> </msub> </mrow> <mo>‾</mo></mover> </math> = 9.0 × 10<sup>4</sup> g/mol) and %yield (89%) of PCL in a short period of time at Sn(Oct)<sub>2</sub> concentration of 0.1 mol% and temperature of 160°C. The mechanism of the ROP of <i>ε</i>-CL with Sn(Oct)<sub>2</sub>/<i>n</i>-HexOH was proposed through the coordination-insertion mechanism.</p>","PeriodicalId":11170,"journal":{"name":"Designed Monomers and Polymers","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2021-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/15685551.2021.1908657","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38899750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}