Drug and alcohol dependence最新文献

{"title":"Brief report: Are changes in cannabis use frequency associated with changes in alcohol use and smoking among people with HIV (PWH) – A substitution question","authors":"Bridget M. Whitney ,&nbsp;Joseph A.C. Delaney ,&nbsp;Lydia N. Drumright ,&nbsp;Robin M. Nance ,&nbsp;Rob J. Fredericksen ,&nbsp;Geetanjali Chander ,&nbsp;Edward R. Cachay ,&nbsp;Nathaniel T. Fox ,&nbsp;Katerina A. Christopoulos ,&nbsp;Karen L. Cropsey ,&nbsp;Michael A. Owens ,&nbsp;Greer A. Burkholder ,&nbsp;Kenneth H. Mayer ,&nbsp;Mary E. McCaul ,&nbsp;Sonia Napravnik ,&nbsp;Conall O’Cleirigh ,&nbsp;Allison R. Webel ,&nbsp;George A. Yendewa ,&nbsp;Michael S. Saag ,&nbsp;Mari M. Kitahata ,&nbsp;Andrew W. Hahn","doi":"10.1016/j.drugalcdep.2025.112958","DOIUrl":"10.1016/j.drugalcdep.2025.112958","url":null,"abstract":"<div><h3>Background</h3><div>We evaluated the harm reduction-based cannabis substitution hypothesis, that increased cannabis use may lead to decreased harmful alcohol or tobacco use, among people with HIV (PWH).</div></div><div><h3>Setting/methods</h3><div>Data are from the Centers for AIDS Research Network of Integrated Clinical Systems (CNICS) cohort between 2009 and 2023. PWH completed longitudinal assessments of cannabis, alcohol, and tobacco use. Two trajectories of change in cannabis use were evaluated: increasing use (initiation and increased use frequency vs. non-increasing use) and decreasing use (abstinence and reduced use frequency vs. non-decreasing use). Associations between changes in frequency of cannabis use and subsequent frequency of alcohol and tobacco use were estimated using time-updated, multivariable linear mixed models. Joint longitudinal and survival models were used to examine associations with hazardous alcohol use.</div></div><div><h3>Results</h3><div>Among 12,143 PWH, 31.9 % reported cannabis use, 17.5 % hazardous alcohol use, and 35.6 % cigarette use at baseline. Compared to those who did not increase use, increasing cannabis use was associated with 0.67 additional drinking days/month (95 %CI:0.42–0.92), 0.25 additional heavy episodic drinking days/month (95 %CI:0.04–0.46), and a 2.2 times higher odds of hazardous alcohol consumption (95 %CI:1.67–2.44). Increasing cannabis use was also associated with 0.60 additional cigarettes/day (95 %CI:0.27–0.93). Initiation of cannabis resulted in similar estimates. Conversely, decreasing cannabis use, with and without abstinence, was associated with less alcohol and cigarette consumption.</div></div><div><h3>Conclusions</h3><div>Increasing cannabis use was associated with more drinking, more hazardous drinking, and higher cigarette intake. Contrary to the cannabis substitution hypothesis, increased cannabis use did not result in a reduction of alcohol or tobacco use among PWH.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"277 ","pages":"Article 112958"},"PeriodicalIF":3.6,"publicationDate":"2025-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145558703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Substances in fentanyl samples in the U.S. illicit drug supply: A decade of trends and regional variations using serial cross-sectional analysis","authors":"Zeynep Hasgul ,&nbsp;Erin Stringfellow ,&nbsp;Mohammad S. Jalali ,&nbsp;Huiru Dong","doi":"10.1016/j.drugalcdep.2025.112953","DOIUrl":"10.1016/j.drugalcdep.2025.112953","url":null,"abstract":"<div><h3>Background</h3><div>Fentanyl has become the dominant opioid in the illicit market in the U.S.; however, trends and variety of substances co-presented in samples involving fentanyl and fentanyl-related substances remain largely unexplored, limiting state public health responses. This paper aims to analyze temporal and geographical trends in substances co-reported with fentanyl in illicit drug supply across the U.S. from 2013 to 2023 to inform overdose prevention strategies.</div></div><div><h3>Methods</h3><div>We conducted a serial cross-sectional analysis using data from the National Forensic Laboratory Information System. At national and state levels, we examined trends in co-reported substance categories: heroin, cocaine, psychostimulants, natural and synthetic cannabinoids, hallucinogens/dissociatives, club drugs, other illicit opioids, prescription opioids, illicit benzodiazepines, prescription benzodiazepines, and xylazine.</div></div><div><h3>Results</h3><div>Among 1,011,034 samples involving fentanyl and fentanyl-related substances, 25.8 % contained at least one additional substance category. Xylazine co-reporting increased significantly from 0.4 % in 2018 to 8.1 % in 2023, becoming the most frequently reported that year, overtaking heroin, which had been the most frequently co-reported substance overall. Geographically, fentanyl co-reporting with xylazine and cocaine was more prevalent on the East Coast, while psychostimulant co-reporting was more common on the West Coast.</div></div><div><h3>Conclusions</h3><div>The rising prevalence of co-reporting xylazine and large geographic variations in co-reported substances highlight the shifts in the illicit drug supply. These findings emphasize the need for enhanced drug supply monitoring and region-specific overdose prevention strategies.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"277 ","pages":"Article 112953"},"PeriodicalIF":3.6,"publicationDate":"2025-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145558804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-specific alterations in brain network topology in methamphetamine use disorder: A graph theory-based fMRI study","authors":"Cheng Xu ,&nbsp;Gangliang Zhong ,&nbsp;Xiyuan Zhang,&nbsp;Yicheng Wei,&nbsp;Xiaotong Li,&nbsp;Zhaoyang Xie,&nbsp;Hang Su,&nbsp;Jiang Du","doi":"10.1016/j.drugalcdep.2025.112952","DOIUrl":"10.1016/j.drugalcdep.2025.112952","url":null,"abstract":"<div><h3>Background</h3><div>Methamphetamine use disorder (MUD) imposes severe neurological and societal challenges, yet the sex-specific alterations in brain network topology remain poorly understood.</div></div><div><h3>Methods</h3><div>Resting-state fMRI data were acquired from 78 patients with MUD (49 male, 29 female) and 65 demographically matched healthy controls (HCs). Functional connectivity matrices were constructed using RESTplus V1.30, and graph metrics (global efficiency, nodal centrality) were computed using GRETNA V2.0.0. Group comparisons (MUD vs. HCs; male vs. female) and correlation analyses with Barratt Impulsiveness Scale scores were conducted, applying false discovery rate correction.</div></div><div><h3>Results</h3><div>Compared to HCs, patients with MUD exhibited disrupted nodal metrics across multiple brain regions, including bilateral anterior-inferior triangular regions, right gyrus rectus, left cuneus, bilateral supplementary motor areas, bilateral parietal regions, and occipital lobes, without significant alterations in global network metrics. Furthermore, significant sex-related main effects were observed in widespread brain areas, involving key nodal metrics such as degree centrality, local efficiency, clustering coefficient, and nodal efficiency. Female patients with MUD demonstrated higher global network measures and showed more extensive nodal metric differences compared to males. These findings highlight distinct sex-dependent network alterations in MUD and emphasize the need for sex-stratified therapeutic approaches targeting specific network vulnerabilities.</div></div><div><h3>Conclusion</h3><div>This study provides evidence of sexually dimorphic network pathology in MUD, revealing that females exhibit widespread front-parietal-occipital disruptions, whereas males demonstrate relative network preservation. These findings underscore the importance of sex-stratified therapeutic strategies targeting network-specific vulnerabilities in MUD.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"277 ","pages":"Article 112952"},"PeriodicalIF":3.6,"publicationDate":"2025-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145474833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nationwide readmission analysis of socioeconomic disparities in heart failure hospitalizations among patients with substance-induced cardiomyopathy","authors":"Nadhem Abdallah ,&nbsp;Momen Alsayed","doi":"10.1016/j.drugalcdep.2025.112951","DOIUrl":"10.1016/j.drugalcdep.2025.112951","url":null,"abstract":"<div><h3>Introduction</h3><div>Lower socioeconomic status (SES) is associated with adverse cardiovascular outcomes; however, limited data exist on heart failure (HF) hospitalizations among patients with substance-induced cardiomyopathy (SICM).</div></div><div><h3>Methods</h3><div>We analyzed the 2016–2019 Nationwide Readmissions Database to identify HF cases with SICM. Patients were stratified by zip code income quartiles (≤2 [&lt; $59,000] vs. ≥3). The primary outcome was mortality. Secondary outcomes included 90-day readmissions, acute kidney injury (AKI), cardiac arrest, length of stay (LOS), and total hospitalization charges (THC). Multivariable regression models adjusted for confounders.</div></div><div><h3>Results</h3><div>Among 8443 HF admissions with SICM, 59 % were lower-income patients. Lower income was associated with increased 90-day readmissions (adjusted OR [aOR] 1.18; 95 % CI, 1.03–1.35), shorter mean LOS (6.2 vs. 7.0 days) and lower THC ($81,702 vs. $105,904). No differences were observed in mortality, AKI, or cardiac arrest.</div></div><div><h3>Conclusion</h3><div>Among HF-SICM cases, lower-income was associated with higher readmission risk despite shorter stays and lower charges.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"277 ","pages":"Article 112951"},"PeriodicalIF":3.6,"publicationDate":"2025-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145454325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of psychological interventions for smoking cessation among incarcerated population: A systematic review and meta-analysis","authors":"Mélanie Rome ,&nbsp;Lucia Romo ,&nbsp;Thibault Hennequin ,&nbsp;Carine Meslot ,&nbsp;Fanny Negre ,&nbsp;Katia Illel ,&nbsp;Oulmann ZERHOUNI ,&nbsp;Xavier Laqueille","doi":"10.1016/j.drugalcdep.2025.112941","DOIUrl":"10.1016/j.drugalcdep.2025.112941","url":null,"abstract":"<div><h3>Objective</h3><div>The prevalence of smoking is disproportionately high in correctional settings. This systematic review and meta-analysis evaluated the efficacy of psychological interventions in promoting smoking cessation among individuals who are currently incarcerated.</div></div><div><h3>Method</h3><div>We systematically searched four databases (PubMed, PsycInfo, Web of Science, and Embase) studies assessing the effectiveness of psychological interventions on smoking cessation. Two meta-analyses were conducted: (1) abstinence rates between psychological interventions and control groups in Randomised Controlled Trials (RCTs), and (2) a pooled analysis of abstinence rates after psychological intervention across follow-up periods. Meta-regression was used to examine the effect of follow-up duration on abstinence.</div></div><div><h3>Results</h3><div>11 studies (N = 2688), including seven RCTs, met the inclusion criteria. Psychological interventions were associated with a significant increase in smoking abstinence compared with control conditions (OR = 3.41, 95 % CI [1.34, 8.70], z = 2.57; <em>p</em> &lt; .05). Yet, this effect was highly heterogeneous (I² = 85.4 %) and became non-significant after adjustment for publication bias (OR = 1.60, 95 % CI [0.51, 5.07]). The pooled post-intervention abstinence rate across follow-up periods was 18.8 % (95 % CI [15.5, 22.1]), with moderate to high heterogeneity (<em>I</em>² = 56.1 %, τ² = 0.1356). Meta-regression revealed a significant decline in abstinence rates over time (log-odds = −0.0099, SE = 0.0051, <em>p</em> = 0.050).</div></div><div><h3>Conclusions</h3><div>Psychological interventions show promise but are limited by high heterogeneity, small sample sizes, and methodological weaknesses. More rigorous and adequately powered studies are needed to establish their effectiveness in correctional settings.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"277 ","pages":"Article 112941"},"PeriodicalIF":3.6,"publicationDate":"2025-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145446830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experiences of healthcare providers caring for pregnant individuals with substance use disorder","authors":"Assumpta Nantume ,&nbsp;Kylie Leong-Bob ,&nbsp;Olivia R. Hanson ,&nbsp;Jami Baayd ,&nbsp;Connie Wilson ,&nbsp;Alexandra Gero ,&nbsp;Karen W. Tao ,&nbsp;Rebecca G. Simmons ,&nbsp;Marcela C. Smid ,&nbsp;Erin P. Johnson ,&nbsp;Torri D. Metz ,&nbsp;Melissa H. Watt ,&nbsp;Susanna R. Cohen","doi":"10.1016/j.drugalcdep.2025.112942","DOIUrl":"10.1016/j.drugalcdep.2025.112942","url":null,"abstract":"<div><h3>Introduction</h3><div>Substance use disorder (SUD) during pregnancy is associated with an increased risk of adverse maternal and neonatal outcomes, yet many patients face significant barriers to accessing treatment, including experiencing bias and stigma from healthcare providers. To inform improvements in care delivery, this study explored the experiences of healthcare providers who care for pregnant individuals with SUD.</div></div><div><h3>Methods</h3><div>Researchers conducted seven focus group discussions (FGD) and fifteen in-depth interviews (IDI) using semi-structured guides, with participants drawn from both rural and urban hospital settings across Utah. All discussions were audio recorded, transcribed verbatim, and examined using the Template Analysis approach.</div></div><div><h3>Results</h3><div>Among FGD participants (n = 37), the sample was predominantly white (94.6 %), female (86.5 %), rural (89.2 %), and comprised of nurses (78.4 %). The IDI sample (n = 15) was more gender diverse (60 % female), had greater representation of physicians (53.3 %), and a higher proportion of urban participants (60.0 %).</div><div>Template analysis revealed four major themes. First, providers held a range of perceptions toward pregnant individuals with SUD, reflecting both stigma and empathy. Second, many emphasized the importance of building trust through nonjudgmental communication and emotional support. Third, providers reported high levels of burnout, particularly due to limited resources and systemic barriers. Finally, participants highlighted knowledge gaps related to SUD clinical care and confusion around regulatory requirements like mandatory reporting.</div></div><div><h3>Conclusions</h3><div>Despite the challenges described, many providers expressed strong dedication to delivering compassionate, person-centered care. The findings underscore the need for targeted provider education, institutional policies that reduce care barriers, and increased community and institutional resources to better support patients with SUD during pregnancy.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"277 ","pages":"Article 112942"},"PeriodicalIF":3.6,"publicationDate":"2025-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145472258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Back on track: Feasibility and efficacy randomized trial of a two-week online self-guided intervention for cannabis use reduction","authors":"E. Kroon ,&nbsp;J.W.B. Elsey ,&nbsp;L.N. Kuhns ,&nbsp;P. Rietveld ,&nbsp;O. De Vries ,&nbsp;H. Larsen ,&nbsp;R.W.H.J. Wiers ,&nbsp;J. Cousijn","doi":"10.1016/j.drugalcdep.2025.112943","DOIUrl":"10.1016/j.drugalcdep.2025.112943","url":null,"abstract":"<div><h3>Background and aims</h3><div>Many individuals aiming to reduce or quit cannabis use prefer self-guided interventions over formal treatment. In this pilot and feasibility randomized trial, we tested a two-week self-guided online intervention combining multiple evidence-based behavior change approaches.</div></div><div><h3>Participants</h3><div>A total of 168 adults who used cannabis weekly, experienced severe cannabis use disorder on average, and reported being motivated to reduce or quit use participated in the baseline assessment and two-week follow-up of this international online intervention study. An additional three-month follow-up was included.</div></div><div><h3>Interventions</h3><div>Participants were randomized into three conditions: SMART goals alone (minimal intervention control), SMART +  mental contrasting with implementation intentions (MCII), or SMART +  MCII +  Cue-control.</div></div><div><h3>Measurements</h3><div>Participants set personal reduction or quit goals. We measured subjective goal achievement, objective goal achievement, and cannabis use reduction in grams per week.</div></div><div><h3>Findings</h3><div>Both intervention conditions outperformed the (minimal intervention) control condition in achieving subjective and objective reduction goals, with 69 % (MCII) and 60 % (MCII + Cue-control) meeting their objective targets compared to 49 % in the control condition. Adding Cue-control to MCII did not enhance outcomes compared to MCII alone. All conditions, including the control, reported similar reductions in cannabis use (grams per week) and these reductions were largely maintained at three-month follow-up. Two-week retention was high in the active intervention groups, especially in the MCII condition, highlighting the accessibility and appeal of the intervention.</div></div><div><h3>Conclusions</h3><div>This pilot and feasibility randomized trial showed promise of this intervention as an accessible and effective self-guided online cannabis reduction program.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"277 ","pages":"Article 112943"},"PeriodicalIF":3.6,"publicationDate":"2025-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145454320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"β-Nicotyrine and e-cigarette abuse liability I: Pharmacodynamics and interaction with pharmacokinetics and discriminative stimulus effects of nicotine in rats","authors":"J.R. Smethells ,&nbsp;S. Wilde ,&nbsp;P. Muelken ,&nbsp;J. Vigliaturo ,&nbsp;M.D. Raleigh ,&nbsp;M. Pravetoni ,&nbsp;K.J. Kellar ,&nbsp;T. Olson ,&nbsp;M.G. LeSage ,&nbsp;A.C. Harris","doi":"10.1016/j.drugalcdep.2025.112949","DOIUrl":"10.1016/j.drugalcdep.2025.112949","url":null,"abstract":"<div><h3>Background</h3><div>β-Nicotyrine (β-Nic) is a prevalent minor alkaloid in electronic nicotine delivery systems (ENDS) aerosols. High doses of β-Nic slow nicotine (Nic) metabolism in mice, suggesting it may alter the abuse liability of ENDS. Thus, the present study examined the pharmacokinetics and pharmacodynamics of β-Nic and Nic, both alone and in combination, including the ability of β-Nic to produce nicotine-like discriminative-stimulus (i.e., subjective) effects and/or enhance the effects of Nic in rats.</div></div><div><h3>Methods and results</h3><div>Unlike Nic and Nornicotine (Nornic) which bound to and activated acetylcholine receptors (α2β2, α3β4, α4β2) in vitro, β-Nic did not bind to these receptors, nor did it bind to a range of noncholinergic receptors (e.g., dopamine, GABA). A clinically relevant β-Nic dose (i.e., 25 % of Nic) slowed Nic clearance by ~50 %. In rats trained to discriminate Nic (0.2<!--> <!-->mg/kg) from Saline (Sal), β-Nic alone weakly substituted for Nic in females, but not males, whereas Nornic substituted for Nic in both sexes. Combinations of Nic + β-Nic increased the discriminability of Nic when administered 10- and 60-min prior to testing. Drug naïve rats learned to discriminate Nornic, but not β-Nic, from Sal.</div></div><div><h3>Conclusions</h3><div>β-Nic slows Nic clearance in rats and enhances and prolongs the discriminative stimulus effects of Nic, suggesting it may contribute to the abuse liability of ENDS.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"277 ","pages":"Article 112949"},"PeriodicalIF":3.6,"publicationDate":"2025-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145414005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bridging the gap: Post-release outcome evaluation of the first jail-based telemedicine buprenorphine program","authors":"Annabelle M. Belcher ,&nbsp;Hannah Smith ,&nbsp;Christopher Welsh ,&nbsp;Heather Fitzsimons ,&nbsp;Angel Dalverny ,&nbsp;Daniel Lasher ,&nbsp;Kelly Coble ,&nbsp;Aaron D. Greenblatt ,&nbsp;Thomas Blue ,&nbsp;Michael Gordon ,&nbsp;Eric Weintraub","doi":"10.1016/j.drugalcdep.2025.112950","DOIUrl":"10.1016/j.drugalcdep.2025.112950","url":null,"abstract":"<div><div>Release from incarceration poses significant risk for opioid-associated overdose. Treatment engagement with medications for opioid use disorder prior to community release is an effective overdose mitigation strategy. But this evidence-based intervention is infrequently implemented in rural jails, a gap that can be addressed with the use of telemedicine. The aim of this study was to evaluate a novel telemedicine buprenorphine (tele-buprenorphine) treatment program for incarcerated people diagnosed with moderate-to-severe opioid use disorder (OUD). We conducted a retrospective chart review of data collected from discharged patients who were enrolled in a rural jail-based telemedicine buprenorphine treatment between 4/26/2021–12/17/2022. Outcome measures included community buprenorphine treatment engagement at two weeks following release from jail (primary) and fatal and/or non-fatal overdose events occurring within two weeks of release from jail (secondary). A total of 151 incarcerated patients were enrolled in the tele-buprenorphine program, 98.7 % (n = 149) of whom remained in buprenorphine treatment throughout custody. Of these 149 patients, six were provided with extended-release buprenorphine prior to release, and 23 were transferred to another jail. Of the 120 patients who were discharged into the community, 78 % (n = 93) were engaged in buprenorphine treatment within the two weeks following release. Significantly more people in this group (75 %) received bridge buprenorphine prescription prior to release. These first-of-its-kind data suggest that like in-person jail-based buprenorphine provision, tele-buprenorphine may increase community treatment engagement and possibly prevent opioid overdose and fatality. This report provides proof-of-concept justification for a unique clinical implementation model that warrants wider adoption and evaluation.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"277 ","pages":"Article 112950"},"PeriodicalIF":3.6,"publicationDate":"2025-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145454369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep quality and duration following the use and co-use of alcohol and cannabis in the daily life of community adults","authors":"Melissa Nance ,&nbsp;Mary Beth Miller ,&nbsp;Jarrod M. Ellingson ,&nbsp;Ryan W. Carpenter","doi":"10.1016/j.drugalcdep.2025.112946","DOIUrl":"10.1016/j.drugalcdep.2025.112946","url":null,"abstract":"<div><h3>Background</h3><div>Sleep-promotion is one of the most common reasons people use cannabis. Previous studies, primarily among young adults, suggest that cannabis use has negligible day-level effects on sleep but may attenuate alcohol’s negative effects when both substances are used. Studies among middle-aged/older adults are needed to determine the generalizability of these day-level associations.</div></div><div><h3>Methods</h3><div>This preregistered secondary data analysis examined daily-life associations between alcohol and cannabis use with next-day sleep quality and duration in a community sample of 48 adults (50 % female; age <em>M</em>=36.42, <em>SD</em>=10.96) reporting weekly alcohol and/or cannabis use. Participants completed ecological momentary assessments over 60 days. Multilevel models examined whether alcohol use, cannabis use, or alcohol-cannabis co-use (vs. no use) that day were associated with sleep quality and duration that night. Next, sleep quality and duration were examined as predictors of next-day craving and alcohol/cannabis use.</div></div><div><h3>Results</h3><div>Cannabis use was associated with longer sleep duration than days of alcohol use, co-use, or no use, which were not different from one another. Sleep quality did not differ following alcohol/cannabis use. Sleep quality and duration were not associated with next-day craving for alcohol or cannabis. Longer sleep duration was associated with higher likelihood of next-day cannabis use.</div></div><div><h3>Conclusions</h3><div>Community adults report sleeping ~15<!--> <!-->min longer on days of cannabis use, unless they also drank alcohol that day. This finding underscores the importance of examining co-use in daily life. Cannabis use demonstrated limited benefits for sleep, which should be evaluated in context with risk for increasing cannabis use over time.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"277 ","pages":"Article 112946"},"PeriodicalIF":3.6,"publicationDate":"2025-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145446802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}