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Evaluation Of The Prophylactic Effect Of Pomegranate Peel Extract And Pumpkin Seed Oil On The Periodontium Of Rats Receiving Methotrexate: Histologic And Immunohistochemical Study 评估石榴皮提取物和南瓜籽油对服用甲氨蝶呤的大鼠牙周膜的预防作用:组织学和免疫组化研究
Pub Date : 2024-07-01 DOI: 10.21608/edj.2024.276913.2980
M. Dahab, S. Morsy
Objectives: One antimetabolite that is frequently used to treat cancer is methotrexate (MTX). Its frequent usage has been linked to negative skeletal effects such decreased bone production and bone loss. This research’s objective was to assess the preventive role of pomegranate peel extract and pumpkin seed oil on the histological and immunohistochemical changes of periodontium of rats receiving methotrexate (MTX). Material and Methods: Thirty-two male albino rats were randomly distributed into four groups.: Group I; normal, Group II; received MTX, Group III and Group IV; received MTX + pomegranate peel extract (PPE) and MTX +pumpkin seed oil (PSO) respectively. Mandibles were viewed under a light microscope for histological analysis using hematoxylin and eosin, specific Masson stain, and immunohistochemical evaluation using the TRAP labelling index that was calculated and statistically assessed. Results: group II showed partial resorbtion for lining of alveolar bone with dissociation of PDL fibers that devoid of fibroblast with more improvement in the histological result in PSO group compared PPE group. Regarding the immunohistochemical results, PSO group displayed a significant decrease in TRAP labelling index compared to other groups. Conclusion: both PPE and PSO could be used as a prophylactic dietary supplement against the adverse effect of MTX on the periodontium although PSO showed more promising effect.
目的:甲氨蝶呤(MTX)是一种常用于治疗癌症的抗代谢药。经常使用这种药物会对骨骼产生负面影响,如骨质生成减少和骨质流失。本研究旨在评估石榴皮提取物和南瓜籽油对接受甲氨蝶呤(MTX)治疗的大鼠牙周组织学和免疫组化变化的预防作用。材料与方法将 32 只雄性白化大鼠随机分为四组:I组:正常,II组:接受MTX治疗,III组和IV组:分别接受MTX+石榴皮提取物(PPE)和MTX+南瓜籽油(PSO)治疗。在光镜下观察下颌骨,使用苏木精和伊红、特异性马森染色进行组织学分析,并使用 TRAP 标记指数进行免疫组化评估,计算并统计评估结果。结果:II 组显示牙槽骨衬里部分吸收,PDL 纤维解离,没有成纤维细胞,与 PPE 组相比,PSO 组的组织学结果改善更多。免疫组化结果显示,与其他组相比,PSO 组的 TRAP 标记指数显著下降。结论:PPE 和 PSO 均可作为预防性膳食补充剂,以防止 MTX 对牙周的不良影响,但 PSO 的效果更佳。
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引用次数: 0
IN-VITRO RETENTION OF HIGH ARCHED MAXILLARY DENTURES CONSTRUCTED FROM CONVENTIONAL, THERMOFORMED, AND MILLED CAD/CAM RESINS. 用传统树脂、热成型树脂和研磨CAD/CAM树脂制作的高拱形上颌假牙的体外固位。
Pub Date : 2024-07-01 DOI: 10.21608/edj.2024.268628.2931
abdullah Ismael Ahmed, Hussein Abdelhady Hussein Taha, Ahmed sholkamy abdelazeem, Dina Bahgat El talawy, E. M. Tolba
Purpose: this study was to evaluate the retention of high-arched maxillary dentures constructed from conventional, thermoformed, and milled CAD/CAM resins. Materials and Methods: An edentulous patient with a high-arched palate was selected from the outpatient clinic, Department of Prosthetic Dentistry, Faculty of Dentistry, Minia University. The patient was seeking complete denture treatment. Using the master cast in this case, thirty stone casts were duplicated, numbered, and randomly allocated to one of three study groups of 10 casts each. Thirty denture bases were constructed from the following materials to be as identical as possible: 10 of each of the following materials: conventional heat-cured resin, thermoformed resin, and milling resin by CAD/CAM. The retention of the produced denture bases was tested using a universal testing machine. Results : The thermoformed group displayed the highest numeric retention mean (5.576 N), followed by CAD/CAM (4.888 N) and the conventional method (3.232 N). There were statistically significant differences between all groups. Conclusions: Within the limitations of this in vitro study, it may be concluded that the thermoformed resin may be the most suitable material for high-arched palates, followed by CAD-CAM materials. The conventional technique in this case is less recommended.
目的:本研究旨在评估用传统树脂、热成型树脂和铣制 CAD/CAM 树脂制作的高拱形上颌义齿的固位情况。材料和方法:在米尼亚大学牙科学院修复牙科系门诊部选取了一名上颚高耸的无牙颌患者。患者正在寻求全口义齿治疗。利用该病例的主铸模,复制了 30 个石头铸模,对其进行编号,并随机分配到三个研究小组中的一个小组,每个小组 10 个铸模。用以下材料制作了 30 个尽可能相同的义齿基托:传统热固化树脂、热成型树脂和 CAD/CAM 铣削树脂,每种材料各 10 个。使用万能试验机测试制作的义齿基托的固位情况。结果:热成型组的固位平均值最高(5.576 N),其次是 CAD/CAM 组(4.888 N)和传统方法组(3.232 N)。各组之间的差异具有统计学意义。结论:在这项体外研究的局限性范围内,可以得出结论:热成型树脂可能是最适合高耸腭的材料,其次是 CAD-CAM 材料。在这种情况下,不太推荐使用传统技术。
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引用次数: 0
Evaluation of retention values of different telescopic crown attachment materials in implant retained overdenture (an in vitro study) 不同伸缩冠连接材料在种植体固位覆盖义齿中的固位值评估(体外研究)
Pub Date : 2024-07-01 DOI: 10.21608/edj.2024.288610.3035
Sherif Mohamed Abdel Hamid, Rim Adel Selima, Mohamed Zaki Basiony
Statement of problem : A variety of attachment materials were employed to improve stability and retention; nevertheless, some materials show considerable alterations in surface topography upon the application of occlusal stress, which eventually affects denture retention. Recent studies have shown a substantial amount of interest in the usage of metal-free attachment. Purpose: the aim of this study was examining the impact of various telescopic crown attachment materials on implant-retained mandibular overdentures’ retention. Material and Methods : completely edentulous mandibular epoxy models were constructed; wherein various material combinations have been used for constructing telescopic attachments for two implants placed in the canine area. The traditional standardized method was used to fabricate thirty-three identical mandibular overdentures. Based on the material utilized in constructing the secondary coping, the study groups were divided into three categories: PEEK/PEEK, PEEK/ZrO 2 , and PEEK/CoCr. For each research group, primary PEEK copings were created. On a prefabricated abutment, primary copings were cemented in place. In the intended insertion path, secondary copings were positioned over the primary copings and then lifted up into the overdentures’ intaglio surface. In order to
问题简介:为了提高义齿的稳定性和固位力,人们使用了多种附着体材料;然而,有些材料在咬合应力作用下表面形貌会发生很大变化,最终影响义齿的固位力。最近的研究表明,人们对使用无金属附着体产生了浓厚的兴趣。目的:本研究旨在探讨各种伸缩冠连接材料对种植体固位下颌覆盖义齿固位的影响。材料和方法:我们制作了完全无牙的下颌环氧树脂模型,其中使用了不同的材料组合来制作两个种植体的伸缩式附着体。采用传统的标准化方法制作了 33 个相同的下颌覆盖义齿。根据构建辅助连接体所使用的材料,研究组被分为三类:PEEK/PEEK、PEEK/ZrO 2 和 PEEK/CoCr。每个研究组都制作了主要的 PEEK 基台。在预制基台上,将主锁模粘接到位。在预定的插入路径上,将副修复体放置在主修复体上,然后将其抬起到覆盖义齿的凹面上。为了
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引用次数: 0
Influence of Implant Inclination on Peri-Implant Bone Stress associated in Mandibular Three Implant Overdentures: A Finite Element Analysis 种植体倾斜度对下颌三种植体覆盖义齿种植体周围骨应力的影响:有限元分析
Pub Date : 2024-07-01 DOI: 10.21608/edj.2024.276457.2978
A. Emarah, Nasser Zaki Ahmed, Mostafa Aldesoki, Kamal Ghamry Metwally, Amr Salah el-din Gomaa
Purpose: This study addresses stress distribution in the peri-implant bone of mandibular overdentures supported by there implants with different inclinations. Materials and methods: Three separate 3D FE models were prepared to simulate mandibular implant overdentures with ball attachments. Each model was modified according to distal implant’s inclination (0, 15, and 25 degrees), while the midline implant was kept straight. Four loads were applied to the denture: clench, masseter, pterygoid, and temporal loads. The behavioral characteristics of the peri-implant bone and the implants were studied and recorded under the applied loads for the three implant inclinations. Results: According to the study, the stress distribution in the mandible varied depending on the implant inclination. The maximum stress observed on the mandible ranged from 19.1 to 36.1 MPa across all cases studied. As the implant inclination increased, the maximum stress and strain increased in both the mandible and implants. However, the rate of increase was found to be less pronounced at higher fixation angles. Conclusion: These findings suggest that implant inclination should be carefully considered to minimize stress and strain on the mandible and implants during treatment planning for implant-supported overdentures.
目的:本研究探讨了由不同倾斜度的种植体支撑的下颌覆盖义齿种植体周围骨的应力分布。材料与方法:制作了三个独立的三维 FE 模型来模拟带球附着体的下颌种植体覆盖义齿。每个模型都根据远端种植体的倾斜度(0、15 和 25 度)进行了修改,而中线种植体则保持平直。对义齿施加了四种负荷:紧握负荷、肌肉负荷、翼状负荷和颞部负荷。研究并记录了三种种植体倾斜度下种植体周围骨质和种植体的行为特征。研究结果根据研究结果,下颌骨的应力分布因种植体的倾斜度而异。在所有研究病例中,下颌骨上观察到的最大应力介于 19.1 到 36.1 兆帕之间。随着种植体倾斜度的增加,下颌骨和种植体的最大应力和应变都在增加。不过,在固定角度较大的情况下,应力和应变的增加率并不明显。结论:这些研究结果表明,在制定种植体支持覆盖义齿的治疗计划时,应仔细考虑种植体的倾斜度,以尽量减少下颌骨和种植体的应力和应变。
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引用次数: 0
Possible Effects of nutmeg oil versus propolis in treatment of chemical induced ulcer on papillae of tongue in albino rats. (Histological and Scanning Electron Microscopic study) 肉豆蔻油与蜂胶在治疗化学物质诱发的白化大鼠舌乳头溃疡方面的可能效果。(组织学和扫描电子显微镜研究)
Pub Date : 2024-07-01 DOI: 10.21608/edj.2024.289606.3042
Aya Hamed Mekky, Eman Ahmed Mounir, Heba A.S. Elnashar, Medhat A. Elzeiny
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引用次数: 0
Comparison of Strain Development of Implant Supported Three Units Fixed Partial Dentures Fabricated from Zirconia and PEEK “In-vitro study” 氧化锆和聚醚醚酮制作的种植体支持三单元固定局部义齿应变发展的比较 "体外研究
Pub Date : 2024-07-01 DOI: 10.21608/edj.2024.280626.2994
Mostafa Hassan, Tarek Salah, Gihan Younis, T. Samhan
Statement of the Problem: selection of prosthetic materials is a critical factor affecting the long-term success of implant supported restorations. PEEK poly-ether-ether ketone-is a quite new polymer used for dental applications. However, there are limited data available concerning Stress analysis and strain development of PEEK restorations as implant superstructure. Introduction; Materials and Methods: A total of 14 frameworks (n=7) were fabricated of Zirconia and PEEK by milling technique, divided into two equal groups to be randomly seated on its corresponding titanium abutment and then subjected to 5000 thermo-cycles. Strain gauge method was selected in this study to assess strain development where strain gauges were adhesively bonded mesial and distal to each implant-abutment unit and data were recorded using a strain meter device. Results: As regards the overall strain (mean of the four channels): there was no statistically significant difference between the two groups. Conclusion: PEEK frameworks revealed slightly higher strain compared to zirconia with o significant difference in the over-all strain channels.
问题陈述:修复材料的选择是影响种植体支持修复体长期成功的关键因素。PEEK 聚醚醚酮是一种用于牙科应用的新型聚合物。然而,有关 PEEK 修复体作为种植体上部结构的应力分析和应变发展的数据非常有限。引言;材料与方法:通过铣削技术制作了 14 个氧化锆和 PEEK 骨架(n=7),将其分为两组,随机安装在相应的钛基台上,然后进行 5000 次热循环。本研究采用应变计法评估应变发展情况,将应变计粘贴在每个种植体-基台单元的中远端,并使用应变计装置记录数据。结果总体应变(四个通道的平均值):两组之间没有统计学意义上的显著差异。结论:与氧化锆相比,PEEK 框架显示的应变略高,但在总体应变通道上没有明显差异。
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引用次数: 0
Assessment of Sealing Ability of Different Bioceramics in Repair of Furcation Perforation: An In Vitro Study 评估不同生物陶瓷在修复窝洞穿孔中的密封能力:体外研究
Pub Date : 2024-07-01 DOI: 10.21608/edj.2024.276541.2979
Radwa Alsherbiny Alnaghy, Tariq Yehia, M. Elfaramawy
Introduction: The objective of this study was to evaluate and compare the sealing ability of MTA, Nano-MTA and Biodentine in the repair of furcation perforation by using bacterial leakage test. Methods and Materials: Standard access cavities and furcal perforations were made in fifty extracted mandibular permanent molars. The teeth were randomly divided into five groups. Group 1: perforations were repaired with MTA, Group 2: perforations were repaired with Nano-MTA and Group 3: perforations were repaired with Biodentine. Ten teeth with unrepaired perforations were used as positive controls and ten teeth without perforations were used as negative controls. The sealing ability was evaluated using Enterococcus faecalis Bacterial leakage test. The samples were observed for 45 days for turbidity using spectrophotometer. Results: High statistically significant difference in leakage was found between the three materials when used as furcation perforation repair materials. Nano-MTA presented the best sealing ability with the least bacterial leakage followed by MTA, while Biodentine showed maximum bacterial leakage. Conclusion: Nano-MTA has better sealing ability than MTA and Biodentine and can be used in repair of furcation perforation.
简介本研究旨在通过细菌渗漏试验,评估和比较 MTA、Nano-MTA 和 Biodentine 在修复窝洞穿孔时的密封能力。方法和材料:在 50 颗拔出的下颌恒磨牙上制作标准的入洞和窝洞穿孔。这些牙齿被随机分为五组。第一组:用 MTA 修复穿孔;第二组:用纳米 MTA 修复穿孔;第三组:用 Biodentine 修复穿孔。10 颗未修复穿孔的牙齿作为阳性对照,10 颗无穿孔的牙齿作为阴性对照。使用粪肠球菌细菌渗漏试验评估密封能力。使用分光光度计对样本进行 45 天的浊度观察。结果三种材料用作毛囊穿孔修补材料时,其渗漏率在统计学上有很大差异。纳米 MTA 的密封能力最强,细菌渗漏最少,其次是 MTA,而生物碱的细菌渗漏最多。结论:纳米 MTA 的密封能力优于 MTA 和 Biodentine,可用于修复窝洞穿孔。
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引用次数: 0
Comparison of the Cyclic fatigue & the Cutting Efficiency of two Rotary NiTi Systems 两种旋转镍钛系统的循环疲劳和切割效率比较
Pub Date : 2024-07-01 DOI: 10.21608/edj.2024.266146.2921
Mostafa Kandil, Ehab Hassanien, S. Fahmy
Purpose: This study compares cyclic fatigue and cutting efficiency of two types of NiTi Rotary files, namely AF one files with a constant 4% taper and Hyflex EDM Files with a variable taper. Materials and Methods: Forty files, twenty of each brand, were examined under a microscope to ensure their integrity before testing. The evaluation focused on cyclic fatigue and cutting efficiency. Cyclic fatigue testing utilized a specialized block simulating dental canals, following Grande et al.’s prescribed design. Lubricating oil flooded the artificial canals, and files were tested at specified RPM and torque until breakage, with recorded breakage times. Cutting efficiency testing involved using plexiglass blocks, and measuring the length of cut during 1 minute. A dedicated device facilitated testing, including an air compressor for debris clearance. Results: Data from both tests were collected and analyzed, revealing that Hyflex EDM files demonstrated superior resistance to cyclic fatigue compared to AF one files(p<0.001). However, AF one files exhibited higher cutting efficiency than Hyflex EDM (p= 0.001), with statistically significant differences in both results. These findings are crucial for dentists in making informed decisions about the choice of files for root canal treatment in their practice.
目的:本研究比较了两种类型的镍钛旋转锉(即锥度恒定为 4% 的 AF one 锉刀和锥度可变的 Hyflex EDM 锉刀)的循环疲劳和切削效率。材料和方法:测试前在显微镜下检查了 40 把锉刀,每个品牌各 20 把,以确保其完整性。评估的重点是循环疲劳和切割效率。根据格兰德等人的规定设计,循环疲劳测试使用了一个模拟牙槽骨的专用块。润滑油渗入人工牙槽骨,锉刀在规定的转速和扭矩下进行测试,直至断裂,并记录断裂时间。切割效率测试包括使用有机玻璃块,测量 1 分钟内的切割长度。专用设备为测试提供了便利,包括用于清除碎屑的空气压缩机。结果:收集并分析了这两项测试的数据,结果显示 Hyflex EDM 锉刀的抗循环疲劳性能优于 AF one 锉刀(p<0.001)。不过,AF one 锉刀的切割效率高于 Hyflex EDM(p= 0.001),两者在统计学上有显著差异。这些发现对牙医在选择根管治疗锉时做出明智的决定至关重要。
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引用次数: 0
Awareness and knowledge of CBCT among a group of Egyptian Pediatric dentists: A questionnaire study 一组埃及儿科牙医对 CBCT 的认识和了解:问卷调查研究
Pub Date : 2024-04-01 DOI: 10.21608/edj.2023.251293.2800
Sarah khalil, Shimaa Abu El Sadat, Reham Elghazawy
Aim: To assess the knowledge and awareness of CBCT among a group of Egyptian pediatric dentists Materials and methods: An online open-ended questionnaire with 21 items were delivered to around 300 applicants, who practice pediatric dentistry in Egypt. The questionnaire was conveyed by Facebook and distributed among different groups, via Whats app groups and messages, through emails and LinkedIn platform. Demographic, knowledge and awareness data regarding CBCT were collected. Categorical data were analyzed using chi square test followed by pairwise comparisons utilizing multiple z-tests with Bonferroni correction. The signi�cance level was set at p ≤ 0.05. Results: Two-hundred twenty-nine participants responded to the survey during a 2-month interval. Almost half of the respondents showed poor knowledge of CBCT, 65.2% believes that adequate teaching is not given to dental students, regarding CBCT in their universities, and 95.2% assumes that continuous education courses is required for pediatric dentists. Conclusions: There is explicit gap in knowledge and awareness of CBCT in pediatric dental practitioners, necessitating additional CBCT education and training courses for both undergraduate and postgraduate students. Clinical relevance: The increase of knowledge and awareness among Egyptian pediatric dentists is required, more training and tuition should be integrated in the students’ curricula in their undergraduate and post graduate stages.
目的:评估一群埃及儿童牙医对 CBCT 的了解和认识 材料和方法:向约 300 名在埃及从事儿童牙科工作的申请人发放了一份包含 21 个项目的在线开放式问卷。问卷通过 Facebook 发送,并通过 Whats app 群组和消息、电子邮件和 LinkedIn 平台在不同群体中分发。收集了有关 CBCT 的人口统计、知识和认知数据。分类数据采用秩方检验进行分析,然后利用多重 Z 检验进行配对比较,并进行 Bonferroni 校正。显著性水平设定为 p ≤ 0.05。结果229 名参与者在两个月的时间内对调查做出了回应。近一半的受访者对CBCT知之甚少,65.2%的受访者认为其所在大学没有为牙科学生提供足够的CBCT教学,95.2%的受访者认为儿科牙医需要参加继续教育课程。结论:儿童牙科医生对 CBCT 的知识和认识存在明显差距,因此有必要为本科生和研究生提供额外的 CBCT 教育和培训课程。临床相关性:需要提高埃及儿童牙科医生的知识和意识,在本科和研究生阶段的学生课程中应纳入更多的培训和教学内容。
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引用次数: 0
Assessment of the Effectiveness of Revascularization Methods Utilizing Platelet-Rich Fibrin (PRF) Concentrate Versus Clot formation as a Supportive Matrix 利用富血小板纤维蛋白 (PRF) 浓缩物与血凝块形成作为支持性基质的血管重建方法的效果评估
Pub Date : 2024-04-01 DOI: 10.21608/edj.2024.264047.2889
Ahmed Soliman
Introduction: Revascularization therapy for young permanent teeth with apical pathology has gained widespread acceptance as an alternative to traditional apexification procedures. In the context of regenerative endodontic treatment (RET), both PRF and clot formation [1] have been used as scaffolds. Objective : This study aimed to evaluate the microscopic tissue-level outcomes of the revascularization process in young permanent premolar dog teeth in vitro. This experimental study aimed to evaluate histological outcomes of the process in immature dog teeth. Methods : Sixty roots that were not fully developed were divided into three experimental groups (control and study) and each group divided again into subgroups (positive and negative) based on the treatment protocol. Moreover, samples from the normal pulp of dog teeth were incorporated. Results : The study group showed a statistically significant increase the percentage of blood vessels and odontoblasts numbers in comparison to the other two groups (P value < 0.001, P=0.003). In terms of inflammatory count, the negative control group showed a higher count in comparison the other two groups Conclusions : Clot formation and Platelet-Rich Plasma (PRP) demonstrated comparable outcomes in periapical healing, specifically regarding mean area fraction of blood vessels and odontoblasts numbers.
导言:对有根尖病变的年轻恒牙进行血管重建治疗,作为传统根尖治疗的替代方法,已被广泛接受。在牙髓再生治疗(RET)中,PRF 和凝块形成[1]都被用作支架。目的:本研究旨在评估体外年轻恒前磨牙狗牙血管新生过程的微观组织水平结果。本实验研究旨在评估未成熟犬牙血管再造过程的组织学结果。方法:将六十颗尚未发育完全的牙根分为三个实验组(对照组和研究组),每组再根据治疗方案分为亚组(阳性组和阴性组)。此外,还加入了狗牙正常牙髓的样本。结果:与其他两组相比,研究组的血管百分比和牙本质细胞数量有显著增加(P 值<0.001,P=0.003)。在炎症计数方面,阴性对照组的计数高于其他两组:凝块形成和血小板丰富血浆(PRP)对根尖周愈合的效果相当,特别是在血管平均面积分数和牙本质细胞数量方面。
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引用次数: 0
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Egyptian dental journal
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