Background: The relation of epicardial fat thickness (EFT) to coronary artery disease (CAD) has recently been reported in multiple studies. Echocardiography is a safe and relatively inexpensive and accessible approach to assess regional EFT, which can be performed easily in many centers.
Objective: To determine the association between echocardiographic EFT and the presence or the absence of CAD.
Methods: This was a systematic review and meta-analysis conducted on literature available in electronic databases up to March 2018. The articles measuring EFT by echocardiography in the right ventricular (RV) free wall were included in the study. The quality of the enrolled items was assessed using the Methodological Index for Non-Randomized Studies (MINORS) checklist. The analyses were performed using the Comprehensive Meta-Analysis version 2 software. Cochran's Q test and I2 index were used to evaluate heterogeneity.
Results: This meta-analysis was performed on 13 studies involving 2,436 patients (1,622 with CAD, and 814 without CAD). The maximum EFT reported by echocardiography was 12.9±2.7 mm in the CAD group and 8.4±2.5 mm in the non-CAD group. The minimum EFT reported by echocardiography was 2.2±1.8 mm in the CAD group and 1.8±1.4 mm in the non-CAD group. The heterogeneity was found among the researched studies (I2=91.8%, p=0.000, Q-value=146.43, df [Q] =12) using the random effect model. The patients with CAD had a significantly higher echocardiographic EFT than those without CAD (SMD=1.03, 95% CI= 0.70-1.37, p=0.000).
Conclusion: According to the findings of this meta-analysis, the echocardiographic EFT in the subjects with CAD was significantly higher than that of those without CAD. The measurement of echocardiographic EFT seems to be an acceptable strategy for risk stratification of heart diseases considering ease of use, cost-effectiveness and non-exposure characteristics, compared to other imaging interventions.
Background: Memory is the basis for the development of language skills and learning processes, and self-efficacy is one of the most important predictors of academic achievement.
Objective: This study aimed to determine the effects of neurofeedback training (NFB) on verbal and visual memory and self-efficacy in students of Rafsanjan University of Medical Sciences.
Methods: This quasi-experimental study was conducted on students of Rafsanjan University of Medical Sciences (Rafsanjan, Iran). Twenty-six students without severe neuropsychological disorder, history of epilepsy and drug abuse were selected randomly and divided into two groups. First, the participants completed the Morgan-Jinks Student Efficacy Scale (MJSES) and then were assessed by Kim Karad Visual Memory Test (KKVMT) and Wechsler Memory Scale for verbal memory (WMSVM). The experimental group underwent 15 sessions of neurofeedback training (NFB) for increase in sensorimotor response (SMR) in central zero (Cz) and fronto-central zero (FCz) location at the psychology clinic Rafsanjan University of Medical Sciences. Visual and verbal memory and self-efficacy were assessed by KKVMT, WMSVM and MJSES after completion of sessions and one month later. Posttest and follow-up of the control group were also carried out simultaneously with the experimental group. Data were analyzed in SPSS version 16, using descriptive statistical and repeated measures ANCOVA. The significance level of examining the hypotheses was set at p≤0.05.
Results: The Mean±SD of verbal memory in the experimental group in pretest, posttest and follow-up was 20±1.9, 22.58±2.1, 22.41±2.06 respectively (p<0.001, Effect size= 0.53).There were significant changes in short-term (p=0.001, Effect size =0.41) and long-term (p=0.001, Effect size =0.42) visual memory. The changes of mid-term visual memory and self-efficacy in the experimental group were not significant (p=0.135, p=0.062).
Conclusion: NFB is effective in improving verbal memory and some dimensions of visual memory. Further studies are needed to achieve better results.
Background: The screening of frailty in older adults is an important issue in the preventive approach in medicine. Frailty is one of the leading causes of morbidity and premature mortality in older adults.
Objective: The aim of this study was to validate the PRISMA-7 questionnaire in community-dwelling elderly people living in Antalya, Turkey.
Methods: This study was cross-sectional and observational in nature and was conducted in Antalya (Turkey) from February 2016 to April 2017. One hundred fifty patients participated in this study. PRISMA-7 and the CSHA Clinical Frailty Scale were applied to these patients along with a questionnaire on socio-demographics. No translations were available for the PRISMA-7 or the CSHA in Turkish language. The PRISMA-7 and the CSHA Clinical Frailty Scale were translated by two translators to Turkish language; after compilation and agreeing to one Turkish translation, the text was translated back by two translators to English. The translation was then compiled to one text and compared with the original text. After agreement on the translation, both translations were piloted in 10 elderly people. The final form has been applied in this study. Data of the ten piloted patients have not been included into the dataset. Data were analyzed by IBM-SPSS version 22, using descriptive statistics, Pearson product-moment correlation, and receiver operator characteristic (ROC) analysis. The level of significance was set at 0.05.
Results: Our study showed that participants were in average vulnerability to frailty. The test-retest reliability score for the PRISMA-7 Scale and for the CSHA Clinical Frailty Scale were (r= 99.2; p<0.001) and (r=97.5; p<0.05), respectively. After using CSHA Clinical Frailty Scale as a reference standard, PRISMA-7 showed that the area under ROC curve (AUC) was 0.903; which is the best accuracy; and medium level for internal consistency (Cronbach's α =0.714) as a measure for reliability. A cut-off point of 4 or higher for PRISMA-7revealed high sensitivity (81.5%) and specificity (88.2%) for frailty.
Conclusion: We would recommend PRISMA-7 as a reliable and valid instrument, with high-level accuracy in the screening process of frailty.