Enfermedades infecciosas y microbiologia clinica最新文献

英文中文

Outbreak of Schistosomiasis mansoni in a Spanish dance and percussion ensemble acquired in the Republic of Guinea 在几内亚共和国获得的西班牙舞蹈和打击乐合奏团中爆发曼氏血吸虫病

IF 2.5 4区医学 Q3 INFECTIOUS DISEASES

Enfermedades infecciosas y microbiologia clinica

Pub Date : 2025-11-01 DOI: 10.1016/j.eimc.2025.01.012

Marta Arsuaga Vicente , Guillermo Ruiz-Carrascoso , Fernando De la Calle-Prieto , Javier Sotillo Gallego , Rosa De Miguel-Buckley , Mar Lago Nuñez , Daniel Mesado Martinez , Marta Díaz Menéndez

Introduction

Schistosomiasis is a neglected tropical disease endemic in 78 countries worldwide. The acute phase, commonly referred to as Katayama fever, is more frequently observed in travelers than in migrants. Despite significant progress in understanding its pathology, many aspects of this disease remain unclear, posing challenges to timely diagnosis and management.

Methods

This observational retrospective study was conducted at the National Referral Unit for Imported Tropical Diseases, located at Hospital La Paz-Carlos III in Madrid, Spain. The study included a total of 14 members of a dance and percussion ensemble that traveled to the Republic of Guinea from March 3 to March 18, 2023. Patients with confirmed or probable schistosomiasis were included in the analysis.

Results

Twelve patients had suspected acute schistosomiasis. Of these, 78.5% were female. The predominant clinical manifestations included fever (91.6%), eosinophilia (100%), acute diarrhea (91.6%), and abdominal pain (83.3%). All patients reported a history of freshwater exposure in Guinea. Schistosoma serology was positive in all cases, and stool samples from five patients revealed the presence of Schistosoma mansoni eggs. Acute symptoms were managed with corticosteroids, leading to clinical improvement in all cases. Thereafter, all patients were treated with praziquantel at a dose of 40 mg/kg/day, administered in two separate doses four weeks apart.

Conclusion

Freshwater exposure in tropical regions is the primary risk factor for acquiring schistosomiasis. Early diagnosis and treatment during the acute phase are crucial to prevent complications and long-term sequelae.

血吸虫病是一种被忽视的热带病，在全世界78个国家流行。急性期，通常称为片山热，在旅行者中比在移民中更常观察到。尽管在了解其病理方面取得了重大进展，但这种疾病的许多方面仍不清楚，对及时诊断和管理提出了挑战。方法本观察性回顾性研究在位于西班牙马德里La Paz-Carlos III医院的国家输入性热带病转诊单位进行。这项研究包括了一个舞蹈和打击乐团的14名成员，他们于2023年3月3日至3月18日前往几内亚共和国。确诊或可能患有血吸虫病的患者被纳入分析。结果12例疑似急性血吸虫病。其中78.5%为女性。主要临床表现为发热（91.6%）、嗜酸性粒细胞增多（100%）、急性腹泻（91.6%）、腹痛（83.3%）。所有患者均报告在几内亚有淡水接触史。所有病例的血吸虫血清学均呈阳性，5例患者的粪便样本显示存在曼氏血吸虫卵。急性症状用皮质类固醇治疗，所有病例的临床改善。此后，所有患者均接受吡喹酮治疗，剂量为40 mg/kg/天，间隔四周分两次给药。结论热带地区淡水暴露是血吸虫病发病的主要危险因素。急性期的早期诊断和治疗对于预防并发症和长期后遗症至关重要。

{"title":"Outbreak of Schistosomiasis mansoni in a Spanish dance and percussion ensemble acquired in the Republic of Guinea","authors":"Marta Arsuaga Vicente , Guillermo Ruiz-Carrascoso , Fernando De la Calle-Prieto , Javier Sotillo Gallego , Rosa De Miguel-Buckley , Mar Lago Nuñez , Daniel Mesado Martinez , Marta Díaz Menéndez","doi":"10.1016/j.eimc.2025.01.012","DOIUrl":"10.1016/j.eimc.2025.01.012","url":null,"abstract":"<div><h3>Introduction</h3><div>Schistosomiasis is a neglected tropical disease endemic in 78 countries worldwide. The acute phase, commonly referred to as Katayama fever, is more frequently observed in travelers than in migrants. Despite significant progress in understanding its pathology, many aspects of this disease remain unclear, posing challenges to timely diagnosis and management.</div></div><div><h3>Methods</h3><div>This observational retrospective study was conducted at the National Referral Unit for Imported Tropical Diseases, located at Hospital La Paz-Carlos III in Madrid, Spain. The study included a total of 14 members of a dance and percussion ensemble that traveled to the Republic of Guinea from March 3 to March 18, 2023. Patients with confirmed or probable schistosomiasis were included in the analysis.</div></div><div><h3>Results</h3><div>Twelve patients had suspected acute schistosomiasis. Of these, 78.5% were female. The predominant clinical manifestations included fever (91.6%), eosinophilia (100%), acute diarrhea (91.6%), and abdominal pain (83.3%). All patients reported a history of freshwater exposure in Guinea. Schistosoma serology was positive in all cases, and stool samples from five patients revealed the presence of <em>Schistosoma mansoni</em><span> eggs. Acute symptoms were managed with corticosteroids, leading to clinical improvement in all cases. Thereafter, all patients were treated with praziquantel at a dose of 40</span> <!-->mg/kg/day, administered in two separate doses four weeks apart.</div></div><div><h3>Conclusion</h3><div>Freshwater exposure in tropical regions is the primary risk factor for acquiring schistosomiasis. Early diagnosis and treatment during the acute phase are crucial to prevent complications and long-term sequelae.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 9","pages":"Pages 571-576"},"PeriodicalIF":2.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145425740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cólicos renoureterales de un año de evolución con urocultivos negativos: desafío diagnóstico 尿道培养呈阴性的1年进化期非尿道结肠炎：诊断挑战

IF 2.5 4区医学 Q3 INFECTIOUS DISEASES

Enfermedades infecciosas y microbiologia clinica

Pub Date : 2025-11-01 DOI: 10.1016/j.eimc.2025.04.004

Ramón Vela-Fernández, Natalia Montiel Quezel-Guerraz, Teresa Trujillo Soto, Manuel Antonio Rodríguez-Iglesias

引用次数: 0

Infección de prótesis articular por Listeria monocytogenes: a propósito de 2 casos clínicos y revisión de la literatura 单核细胞增生李斯特菌关节假体感染：针对2例临床病例和文献综述

IF 2.5 4区医学 Q3 INFECTIOUS DISEASES

Enfermedades infecciosas y microbiologia clinica

Pub Date : 2025-11-01 DOI: 10.1016/j.eimc.2025.05.003

Begoña Fachal Bugarín, Lucía Ramos Merino, Joaquín Manuel Serrano Arreba, Alicia Alonso Álvarez, Ramón María Fernández Varela, Berta Pernas Souto, Laura Gutiérrez Fernández, María Dolores Sousa Regueiro, Enrique Míguez Rey, Efrén Sánchez Vidal

Introduction

Most infections caused by Listeria monocytogenes occur in individuals with predisposing conditions, such as advanced age or the use of immunosuppressive therapies, and primarily manifest as bacteremia or meningoencephalitis. Osteoarticular infections are uncommon and typically affect joint prostheses, with late-onset infections following surgery. Treatment in these cases should include antibiotic therapy along with a surgical strategy, which generally involves the removal of the affected prosthesis.

Methods

Two cases of prosthetic joint infection caused by L. monocytogenes are presented, along with a narrative review of the English and Spanish literature via PubMed® up to December 2024.

Results

To the best of our knowledge, 52 cases of prosthetic joint infection caused by L. monocytogenes have been reported since 2000. All patients had predisposing conditions, with advanced age being the most common (mean age of 71 years). Most cases were late infections following surgery. Combined treatment (antibiotic therapy and surgery) was used in two-thirds of cases. The prognosis was favorable in almost all instances.

Discussion

It is important to consider L. monocytogenes in the etiological diagnosis of prosthetic joint infections, especially in elderly or immunocompromised patients. While the most used antibiotics have been ampicillin and cotrimoxazole, oxazolidinones could serve as an oral alternative for the treatment of these infections.

大多数由单核细胞增生李斯特菌引起的感染发生在有易感条件的个体中，如高龄或使用免疫抑制疗法，主要表现为菌血症或脑膜脑炎。骨关节感染不常见，通常影响关节假体，手术后迟发性感染。这些病例的治疗应包括抗生素治疗和手术治疗，通常包括切除受影响的假体。方法报告2例由单核增生L.菌引起的假体关节感染病例，并通过PubMed®对截至2024年12月的英文和西班牙文文献进行叙述性回顾。结果自2000年以来，共报告52例假体关节感染病例。所有患者都有易感条件，以高龄最常见（平均年龄71岁）。大多数病例为手术后晚期感染。三分之二的病例采用联合治疗（抗生素治疗和手术）。几乎所有病例的预后都是良好的。在假体关节感染的病原学诊断中，特别是在老年人或免疫功能低下的患者中，考虑单核细胞增生乳杆菌是很重要的。虽然最常用的抗生素是氨苄西林和复方新诺明，但恶唑烷酮可以作为治疗这些感染的口服替代药物。

{"title":"Infección de prótesis articular por Listeria monocytogenes: a propósito de 2 casos clínicos y revisión de la literatura","authors":"Begoña Fachal Bugarín, Lucía Ramos Merino, Joaquín Manuel Serrano Arreba, Alicia Alonso Álvarez, Ramón María Fernández Varela, Berta Pernas Souto, Laura Gutiérrez Fernández, María Dolores Sousa Regueiro, Enrique Míguez Rey, Efrén Sánchez Vidal","doi":"10.1016/j.eimc.2025.05.003","DOIUrl":"10.1016/j.eimc.2025.05.003","url":null,"abstract":"<div><h3>Introduction</h3><div>Most infections caused by <em>Listeria monocytogenes</em> occur in individuals with predisposing conditions, such as advanced age or the use of immunosuppressive therapies, and primarily manifest as bacteremia or meningoencephalitis. Osteoarticular infections are uncommon and typically affect joint prostheses, with late-onset infections following surgery. Treatment in these cases should include antibiotic therapy along with a surgical strategy, which generally involves the removal of the affected prosthesis.</div></div><div><h3>Methods</h3><div>Two cases of prosthetic joint infection caused by <em>L. monocytogenes</em> are presented, along with a narrative review of the English and Spanish literature via PubMed® up to December 2024.</div></div><div><h3>Results</h3><div>To the best of our knowledge, 52 cases of prosthetic joint infection caused by <em>L. monocytogenes</em> have been reported since 2000. All patients had predisposing conditions, with advanced age being the most common (mean age of 71 years). Most cases were late infections following surgery. Combined treatment (antibiotic therapy and surgery) was used in two-thirds of cases. The prognosis was favorable in almost all instances.</div></div><div><h3>Discussion</h3><div>It is important to consider <em>L. monocytogenes</em> in the etiological diagnosis of prosthetic joint infections, especially in elderly or immunocompromised patients. While the most used antibiotics have been ampicillin and cotrimoxazole, oxazolidinones could serve as an oral alternative for the treatment of these infections.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 9","pages":"Pages 591-595"},"PeriodicalIF":2.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145425687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ante una picadura de garrapata en España, ¿qué riesgo de infección hay? 在西班牙，蜱虫叮咬有多大的感染风险？

IF 2.5 4区医学 Q3 INFECTIOUS DISEASES

Enfermedades infecciosas y microbiologia clinica

Pub Date : 2025-11-01 DOI: 10.1016/j.eimc.2025.06.012

María Cruz Calvo Reyes , Juan Antonio del Castillo Polo , Esther García-Expósito , Esteban Aznar Cano , Laura Santos Larrégola , María José Sierra Moros , Lucía García-San Miguel

Introduction

The development of parameters to estimate the risk of transmission of infections is one of the objectives of entomological surveillance, included in the National Plan for the Prevention, Surveillance and Control of Vector-Borne Diseases. This study aims to assess the utility of the infection prevalence (IP) of Rickettsia spp., Borrelia burgdorferi, and Crimean-Congo haemorrhagic fever virus in ticks in Spain, as an indicator of the risk of infection from a tick bite and for temporal and geographical comparisons.

Methods

The IP and its 95% confidence interval were calculated for the different microorganism-tick pairs, using data published until April 2024, obtained through a systematic literature review. Studies that included pathogen detection using molecular methods in ticks collected from vegetation (questing ticks) were selected.

Results

Five hundred and eighty-one articles were reviewed, and 20 were selected. The IP of Rickettsia spp. in Dermacentor marginatus was 84.4%, in D. reticulatus 45.9%, and in Rhipicephalus sanguineus 21.2%, with some Rickettsia species causing DEBONEL (R. raoultii and R. slovaca) and MSF-like illness (R. massiliae) being the most frequent. The IP of Borrelia burgdorferi sensu lato in Ixodes ricinus was 5.9%. The IP of Crimean-Congo haemorrhagic fever virus in Hyalomma spp. was 0.3%.

Conclusions

The IP varies for each pathogen-tick pair, from very high for Rickettsia in Dermacentor, to relatively low for Borrelia in Ixodes and Crimean-Congo haemorrhagic fever virus in Hyalomma. The IP in ticks can be a useful indicator, along with other factors, for estimating the risk of infection from a tick bite and conducting population risk assessments in Spain.

制定参数以估计感染传播的风险是昆虫学监测的目标之一，已列入《国家媒介传播疾病预防、监测和控制计划》。本研究旨在评估西班牙蜱虫中立克次体、伯氏疏螺旋体和克里米亚-刚果出血热病毒感染流行率（IP）的效用，作为蜱叮咬感染风险的指标，并进行时间和地理比较。方法利用截至2024年4月发表的文献资料，计算不同微生物-蜱虫对的IP值及其95%置信区间。选择了利用分子方法对植物采集的蜱进行病原检测的研究（探索蜱）。结果共审稿581篇，入选20篇。立克次体在边缘革螨中的感染率为84.4%，在网状革螨中的感染率为45.9%，在血鼻头虫中的感染率为21.2%，其中一些立克次体引起的疾病（拉乌尔氏革螨和斯洛瓦氏革螨）和无国界医生样疾病（马氏革螨）最为常见。蓖麻伊蚊中感应伯氏疏螺旋体的感染率为5.9%。克里米亚-刚果出血热病毒在透明眼蝇中的感染率为0.3%。结论不同病原体-蜱对的IP值不同，革螨的立克次体IP值较高，伊蚊的伯氏体IP值较低，透明瘤的克里米亚-刚果出血热病毒IP值较低。在西班牙，蜱虫中的IP可作为一个有用的指标，与其他因素一起，用于估计蜱虫叮咬感染的风险并进行人口风险评估。

{"title":"Ante una picadura de garrapata en España, ¿qué riesgo de infección hay?","authors":"María Cruz Calvo Reyes , Juan Antonio del Castillo Polo , Esther García-Expósito , Esteban Aznar Cano , Laura Santos Larrégola , María José Sierra Moros , Lucía García-San Miguel","doi":"10.1016/j.eimc.2025.06.012","DOIUrl":"10.1016/j.eimc.2025.06.012","url":null,"abstract":"<div><h3>Introduction</h3><div>The development of parameters to estimate the risk of transmission of infections is one of the objectives of entomological surveillance, included in the National Plan for the Prevention, Surveillance and Control of Vector-Borne Diseases. This study aims to assess the utility of the infection prevalence (IP) of <em>Rickettsia</em> spp., <em>Borrelia burgdorferi</em>, and Crimean-Congo haemorrhagic fever virus in ticks in Spain, as an indicator of the risk of infection from a tick bite and for temporal and geographical comparisons.</div></div><div><h3>Methods</h3><div>The IP and its 95% confidence interval were calculated for the different microorganism-tick pairs, using data published until April 2024, obtained through a systematic literature review. Studies that included pathogen detection using molecular methods in ticks collected from vegetation (questing ticks) were selected.</div></div><div><h3>Results</h3><div>Five hundred and eighty-one articles were reviewed, and 20 were selected. The IP of <em>Rickettsia</em> spp. in <em>Dermacentor marginatus</em> was 84.4%, in <em>D. reticulatus</em> 45.9%, and in <em>Rhipicephalus sanguineus</em> 21.2%, with some <em>Rickettsia</em> species causing DEBONEL (<em>R. raoultii</em> and <em>R. slovaca</em>) and MSF-like illness <em>(R. massiliae)</em> being the most frequent. The IP of <em>Borrelia burgdorferi</em> <em>sensu lato</em> in <em>Ixodes ricinus</em> was 5.9%. The IP of Crimean-Congo haemorrhagic fever virus in <em>Hyalomma</em> spp. was 0.3%.</div></div><div><h3>Conclusions</h3><div>The IP varies for each pathogen-tick pair, from very high for <em>Rickettsia</em> in <em>Dermacentor</em>, to relatively low for <em>Borrelia</em> in <em>Ixodes</em> and Crimean-Congo haemorrhagic fever virus in <em>Hyalomma</em>. The IP in ticks can be a useful indicator, along with other factors, for estimating the risk of infection from a tick bite and conducting population risk assessments in Spain.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 9","pages":"Pages 600-606"},"PeriodicalIF":2.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145425690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cribado de infecciones de transmisión sexual en población trans e interacción del tratamiento hormonal reafirmante de género con la terapia antirretroviral 对跨性别人群中的性传播感染进行筛查，以及性别强化激素治疗与抗逆转录病毒治疗之间的相互作用

IF 2.5 4区医学 Q3 INFECTIOUS DISEASES

Enfermedades infecciosas y microbiologia clinica

Pub Date : 2025-11-01 DOI: 10.1016/j.eimc.2025.04.006

Esteban Sánchez-Toscano , Dunia Collazo-Yáñez , Jesús Domínguez-Riscart , Laura Larrán-Escandón , Andrés Martín-Aspas , Isabel Mateo-Gavira , Manuel Aguilar-Diosdado

Introduction

Current evidence suggests that transgender people have a higher risk of sexually transmitted infections (STIs) than general population, although most of the literature focuses on transwomen with HIV.

Objective

To determine the prevalence of STDs diagnosed by serology in transgender population in our hospital and to analyze the impact of antiretroviral treatment on hormonal therapy.

Methods

We design a cross-sectional study based on medical records of transgender people treated at the Transgender Care Unit of Cadiz from June 2022 to June 2023. Hepatitis, HIV and syphilis serology was requested from people between 16 and 65 years.

Results

A total of 295 people were included, 48,14% transwomen (n = 142) and 51,86% transmen (n = 153), with an average age of 24,78 ± 9,2 years. It was detected 14 cases of HAV, 5 of syphilis, 3 of HBV and 3 of HCV. Prevalence of HIV was 3,73% (n = 11). Of the 9 transwomen with HIV infection, 3 of them required a change in antiretroviral medication and 2 cases required changes in the route of estrogen administration to achieve optimal plasma hormone levels.

Conclusions

With the current model of care for transgender people in Andalusia, the prevalence of STDs detected in our sociocultural environment is low. Special attention should be paid to possible interactions between antiretroviral treatment and hormone therapy, especially in transwomen.

目前的证据表明，变性人患性传播感染（STIs）的风险高于一般人群，尽管大多数文献关注的是感染艾滋病毒的变性女性。目的了解我院跨性别人群性传播疾病血清学诊断情况，分析抗逆转录病毒治疗对激素治疗的影响。方法基于2022年6月至2023年6月在加的斯变性人护理中心治疗的变性人的医疗记录，设计了一项横断面研究。肝炎、艾滋病毒和梅毒的血清学要求来自16至65岁之间的人。结果共纳入295人，其中跨性别者占48.14% (n = 142)，跨性别者占51.86% (n = 153)，平均年龄（24.78±9.2）岁。检出甲型肝炎14例，梅毒5例，乙型肝炎3例，丙型肝炎3例。HIV患病率为3.73% （n = 11）。9例感染HIV的跨性别女性中，3例需要改变抗逆转录病毒药物治疗，2例需要改变雌激素给药途径以达到最佳血浆激素水平。结论在安达卢西亚现有的跨性别人群护理模式下，性病检出率在我们的社会文化环境中较低。应特别注意抗逆转录病毒治疗和激素治疗之间可能的相互作用，特别是在跨性别妇女中。

{"title":"Cribado de infecciones de transmisión sexual en población trans e interacción del tratamiento hormonal reafirmante de género con la terapia antirretroviral","authors":"Esteban Sánchez-Toscano , Dunia Collazo-Yáñez , Jesús Domínguez-Riscart , Laura Larrán-Escandón , Andrés Martín-Aspas , Isabel Mateo-Gavira , Manuel Aguilar-Diosdado","doi":"10.1016/j.eimc.2025.04.006","DOIUrl":"10.1016/j.eimc.2025.04.006","url":null,"abstract":"<div><h3>Introduction</h3><div>Current evidence suggests that transgender people have a higher risk of sexually transmitted infections (STIs) than general population, although most of the literature focuses on transwomen with HIV.</div></div><div><h3>Objective</h3><div>To determine the prevalence of STDs diagnosed by serology in transgender population in our hospital and to analyze the impact of antiretroviral treatment on hormonal therapy.</div></div><div><h3>Methods</h3><div>We design a cross-sectional study based on medical records of transgender people treated at the Transgender Care Unit of Cadiz from June 2022 to June 2023. Hepatitis, HIV and syphilis serology was requested from people between 16 and 65 years.</div></div><div><h3>Results</h3><div>A total of 295 people were included, 48,14% transwomen (n=142) and 51,86% transmen (n=153), with an average age of 24,78±9,2 years. It was detected 14 cases of HAV, 5 of syphilis, 3 of HBV and 3 of HCV. Prevalence of HIV was 3,73% (n=11). Of the 9 transwomen with HIV infection, 3 of them required a change in antiretroviral medication and 2 cases required changes in the route of estrogen administration to achieve optimal plasma hormone levels.</div></div><div><h3>Conclusions</h3><div>With the current model of care for transgender people in Andalusia, the prevalence of STDs detected in our sociocultural environment is low. Special attention should be paid to possible interactions between antiretroviral treatment and hormone therapy, especially in transwomen.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 9","pages":"Pages 585-590"},"PeriodicalIF":2.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145425744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A propósito de un caso: mastitis puerperal complicada 关于一个案例：复杂的产后乳腺炎

IF 2.5 4区医学 Q3 INFECTIOUS DISEASES

Enfermedades infecciosas y microbiologia clinica

Pub Date : 2025-11-01 DOI: 10.1016/j.eimc.2025.02.009

Maialen Larrea Ayo, Begoña Vilar Achabal, Elena Urra Zalbidegoitia, Mikel Gallego Rodrigo

引用次数: 0

Celulitis meningocócica en contexto de infección por SARS-CoV-2: una presentación inusual SARS-CoV-2感染背景下的脑膜炎球菌性细胞炎：不寻常的发病

IF 2.5 4区医学 Q3 INFECTIOUS DISEASES

Enfermedades infecciosas y microbiologia clinica

Pub Date : 2025-11-01 DOI: 10.1016/j.eimc.2025.06.004

María Calle Romero, Patricia de la Montaña Díaz, Montserrat Rodríguez Gómez, Fernando Martínez Sagasti

引用次数: 0

More on endocarditis risk scores in gram positive bacteremias: Caveats to their implantation in clinical practice 更多关于革兰氏阳性菌血症的心内膜炎风险评分：临床实践中植入的注意事项

IF 2.5 4区医学 Q3 INFECTIOUS DISEASES

Enfermedades infecciosas y microbiologia clinica

Pub Date : 2025-11-01 DOI: 10.1016/j.eimc.2025.05.001

Itziar Diego-Yagüe , Antonio Ramos-Martinez , Jorge Calderón-Parra

引用次数: 0

Un año de la Alianza Latinoamericana en Enfermedades Infecciosas y Microbiología Clínica: logros alcanzados y desafíos futuros 拉丁美洲传染病和临床微生物学伙伴关系一年：已取得的成就和未来的挑战

IF 2.5 4区医学 Q3 INFECTIOUS DISEASES

Enfermedades infecciosas y microbiologia clinica

Pub Date : 2025-11-01 DOI: 10.1016/j.eimc.2025.04.005

Francisco Javier Membrillo de Novales , Alfonso J. Rodriguez-Morales , Adriana Sucari , Nancy Virginia Sandoval Paiz , Ivan Arturo Rodríguez Sabogal , Wendy Moncada Navas , Susana Lloveras , Gustavo Lopardo , Virgilio Lezcano , Alexis M. Holguin , Inés Cerón , Rosa Abreu , Míriam J. Álvarez-Martínez , en nombre de la Alianza Latinoamericana de Enfermedades Infecciosas y Microbiología Clínica (ALEIMC)

引用次数: 0

External validation of the HANDOC score in a Spanish cohort—Analysis of blood culture scoring and time to positivity 西班牙队列中HANDOC评分的外部验证——血培养评分和阳性时间分析

IF 2.5 4区医学 Q3 INFECTIOUS DISEASES

Enfermedades infecciosas y microbiologia clinica

Pub Date : 2025-11-01 DOI: 10.1016/j.eimc.2024.12.024

Pedro Manuel García-Ceberino , Francisco Anguita-Santos , Jara Llenas-García , Miguel Ángel Montero-Alonso , Natalia Chueca-Porcuna , Emilio Borrajo , Adolfo de Salazar , Ana María Hernández-Campillo , Emilio Guirao-Arrabal , Andrés Ruiz-Sancho

Introduction

Bacteremia caused by gram-positive cocci (GPC) remains challenging, particularly in assessing the risk of infective endocarditis (IE). Various scoring systems have been developed to guide the use of echocardiography. The HANDOC score was specifically designed for non-β-hemolytic streptococci (NBHS). This study aimed to validate the HANDOC score in a cohort across diverse geographic settings.

Methods

A retrospective study enrolled patients with NBHS bacteremia from 2017 to 2021 at two Spanish hospitals. Cases of IE were defined according to European Society of Cardiology 2015 modified Duke criteria. Patient characteristics were extracted from medical records for the analysis of HANDOC score validation in our cohort.

Results

Among 280 patients diagnosed with NBHS bacteremia, 31 met the modified Duke criteria for infective endocarditis (11.1%). Using a cutoff of ≥3, the HANDOC score demonstrated a sensitivity of 95%, specificity of 74% and a negative predictive value of 98%. The same metrics were analyzed with an adapted score based on positive blood culture vials, yielding similar results. Time to positivity (TTP) was analyzed with different cutoffs or by each NBHS group showing no statistically significant difference.

Conclusions

The HANDOC score is a valuable tool for decision-making in NBHS bacteriemia in a Spanish cohort. Scoring by vials may be employed for blood culture item in different clinical settings. Time-to-positivity did not show a significant difference that would justify its potential inclusion in the score.

由革兰氏阳性球菌（GPC）引起的菌血症仍然具有挑战性，特别是在评估感染性心内膜炎（IE）的风险方面。各种评分系统已经开发出来，以指导超声心动图的使用。HANDOC评分是专门为非β溶血性链球菌（NBHS）设计的。本研究旨在在不同地理环境的队列中验证HANDOC评分。方法回顾性研究纳入2017年至2021年西班牙两家医院的NBHS菌血症患者。IE病例根据欧洲心脏病学会2015年修订的杜克标准进行定义。从医疗记录中提取患者特征，对我们的队列进行HANDOC评分验证分析。结果280例NBHS菌血症患者中，31例（11.1%）符合杜克感染性心内膜炎修正标准。采用≥3的截止值，HANDOC评分的敏感性为95%，特异性为74%，阴性预测值为98%。采用基于阳性血培养瓶的适应性评分分析相同的指标，得出类似的结果。采用不同的截止点或各NBHS组对阳性时间（TTP）进行分析，差异无统计学意义。结论HANDOC评分是西班牙队列中NBHS菌血症的一个有价值的决策工具。在不同的临床环境中，血液培养项目可采用小瓶计分法。达到积极状态的时间并没有显示出显著的差异，这可以证明将其纳入得分的可能性。

{"title":"External validation of the HANDOC score in a Spanish cohort—Analysis of blood culture scoring and time to positivity","authors":"Pedro Manuel García-Ceberino , Francisco Anguita-Santos , Jara Llenas-García , Miguel Ángel Montero-Alonso , Natalia Chueca-Porcuna , Emilio Borrajo , Adolfo de Salazar , Ana María Hernández-Campillo , Emilio Guirao-Arrabal , Andrés Ruiz-Sancho","doi":"10.1016/j.eimc.2024.12.024","DOIUrl":"10.1016/j.eimc.2024.12.024","url":null,"abstract":"<div><h3>Introduction</h3><div>Bacteremia caused by gram-positive cocci (GPC) remains challenging, particularly in assessing the risk of infective endocarditis (IE). Various scoring systems have been developed to guide the use of echocardiography. The HANDOC score was specifically designed for non-β-hemolytic streptococci (NBHS). This study aimed to validate the HANDOC score in a cohort across diverse geographic settings.</div></div><div><h3>Methods</h3><div>A retrospective study enrolled patients with NBHS bacteremia from 2017 to 2021 at two Spanish hospitals. Cases of IE were defined according to European Society of Cardiology 2015 modified Duke criteria. Patient characteristics were extracted from medical records for the analysis of HANDOC score validation in our cohort.</div></div><div><h3>Results</h3><div>Among 280 patients diagnosed with NBHS bacteremia, 31 met the modified Duke criteria for infective endocarditis (11.1%). Using a cutoff of ≥3, the HANDOC score demonstrated a sensitivity of 95%, specificity of 74% and a negative predictive value of 98%. The same metrics were analyzed with an adapted score based on positive blood culture vials, yielding similar results. Time to positivity (TTP) was analyzed with different cutoffs or by each NBHS group showing no statistically significant difference.</div></div><div><h3>Conclusions</h3><div>The HANDOC score is a valuable tool for decision-making in NBHS bacteriemia in a Spanish cohort. Scoring by vials may be employed for blood culture item in different clinical settings. Time-to-positivity did not show a significant difference that would justify its potential inclusion in the score.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 9","pages":"Pages 555-562"},"PeriodicalIF":2.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145425741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

首页上一页

下一页尾页

类型

全部化学•材料生命科学医学物理工程技术环境•农林材料科学地球科学法学管理学化学环境科学与生态学计算机科学教育学经济学农林科学人文科学生物学数学物理与天体物理心理学综合性期刊其他工业工程理学历史学农学文学信息工程

数据库

全部 ACS Publications Elsevier ieeexplore Springer The Royal Society of Chemistry Wiley

期刊

Enfermedades infecciosas y microbiologia clinica

全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.

﹀