Enfermedades infecciosas y microbiologia clinica最新文献

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Patología infecciosa importada desde el hemisferio norte 从北半球传入的传染病学

IF 2.6 4区医学 Q3 INFECTIOUS DISEASES

Enfermedades infecciosas y microbiologia clinica

Pub Date : 2024-10-01 DOI: 10.1016/j.eimc.2023.12.009

引用次数: 0

Uso de isavuconazol en la meningitis criptocócica de un paciente cirrótico 在一名肝硬化患者的隐球菌脑膜炎中使用异黄酮唑

IF 2.6 4区医学 Q3 INFECTIOUS DISEASES

Enfermedades infecciosas y microbiologia clinica

Pub Date : 2024-10-01 DOI: 10.1016/j.eimc.2024.04.008

Jesús Fernández Plaza , Sandra Gregorio Malagón , Manuel Poyato Borrego , Rafael Luque Márquez

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Lo agresivo no siempre es tumoral: osteomielitis por Bartonella henselae 侵袭性并不总是肿瘤性的：鸡形巴顿氏菌骨髓炎

IF 2.6 4区医学 Q3 INFECTIOUS DISEASES

Enfermedades infecciosas y microbiologia clinica

Pub Date : 2024-10-01 DOI: 10.1016/j.eimc.2024.03.010

引用次数: 0

Usefulness of decentralized sequencing networks on antimicrobial resistance surveillance 分散测序网络对抗菌药耐药性监测的作用

IF 2.6 4区医学 Q3 INFECTIOUS DISEASES

Enfermedades infecciosas y microbiologia clinica

Pub Date : 2024-10-01 DOI: 10.1016/j.eimc.2024.04.011

引用次数: 0

Proponiendo el cambio de denominación de la viruela del mono (Mpox) en español a viruela M 建议将猴痘（Mpox）的西班牙语名称改为 Mpox。

IF 2.6 4区医学 Q3 INFECTIOUS DISEASES

Enfermedades infecciosas y microbiologia clinica

Pub Date : 2024-10-01 DOI: 10.1016/j.eimc.2024.08.002

Francisco Javier Membrillo de Novales , Jaime García Iglesias , Miriam J. Álvarez-Martínez , Luis E. Cuellar , María Eugenia Gutiérrez-Pimentel , Alexis M. Holguin , Virgilio Lezcano , Susana Lloveras , Mariella Raijmakers , Iván Arturo Rodríguez Sabogal , Adriana Sucari , Alfonso J. Rodriguez-Morales , en nombre de la Alianza Latinoamericana de Enfermedades Infecciosas y Microbiología Clínica (ALEIMC)

引用次数: 0

Desafíos y estrategias en la prevención del dengue: un reto para la salud pública 预防登革热的挑战和战略：公共卫生挑战

IF 2.6 4区医学 Q3 INFECTIOUS DISEASES

Enfermedades infecciosas y microbiologia clinica

Pub Date : 2024-10-01 DOI: 10.1016/j.eimc.2024.03.007

引用次数: 0

Recently acquired hepatitis C: Epidemiological characteristics and treatment response in a large cohort of MSM living with HIV in Madrid 新近感染的丙型肝炎：马德里大批感染艾滋病毒的男男性行为者的流行病学特征和治疗反应

IF 2.6 4区医学 Q3 INFECTIOUS DISEASES

Enfermedades infecciosas y microbiologia clinica

Pub Date : 2024-10-01 DOI: 10.1016/j.eimc.2023.06.011

Introduction

We analyzed epidemiological, clinical characteristics, and the response to treatment in people living with HIV (PLHIV) who recently acquired hepatitis C (RAHC) in a multicentre study in Madrid (Spain).

Methods

Multicenter, ambispective, observational study of RAHC in men who have sex with men (MSM) infected with HIV. Clinical, epidemiological, and RAHC evolution were recorded prospectively in 2019 and 2020 and retrospectively in 2017 and 2018. In patients who received HCV treatment, sustained virological response (SVR) was provided 12 weeks after the end of treatment in an intention to treat analysis (ITT): all treated patients were included; and in analysis per-protocol (PP): missing patients were excluded.

Results

Overall, 133 patients were included. Median (IQR) age was 40 (34.3–46.1) years, 90.9% had at least one previous sexual transmission disease (STD), and 33.6% had previously hepatitis C. More than half of the prospective sample included patients using chemsex related drugs (57.3%), 45.7% of them intravenously. The most prevalent genotype was G1a (66.2%), followed by G4 (11.3%). Ten of 90 patients evaluated for spontaneous cure (11%) cured the infection spontaneously, and 119 had treatment after a median time of 1.8 (0.7–4.6) months: sustained virological response (SVR) was achieved in 90.7% in the ITT and 94.7% in the PP analysis, with no differences regarding the direct-acting antiviral agents (DAA) combination used.

Conclusions

MSM infected by HIV with a RAHC were exposed to high-risk sexual behavior. Spontaneous cure rate was low, while SVR after treatment was achieved by more than 90%.

导言：我们在马德里（西班牙）的一项多中心研究中分析了最近感染丙型肝炎（RAHC）的艾滋病病毒感染者（PLHIV）的流行病学、临床特征和治疗反应。2019年和2020年对临床、流行病学和RAHC演变进行了前瞻性记录，2017年和2018年进行了回顾性记录。在接受HCV治疗的患者中，持续病毒学应答（SVR）在治疗结束后12周进行意向治疗分析（ITT）：纳入所有接受治疗的患者；按方案分析（PP）：排除缺失患者。中位（IQR）年龄为 40（34.3-46.1）岁，90.9% 的患者至少曾患一种性传播疾病（STD），33.6% 的患者曾患丙型肝炎。最常见的基因型是 G1a（66.2%），其次是 G4（11.3%）。在接受自发治愈评估的 90 名患者中，有 10 人（11%）自发治愈了感染，119 人在接受治疗后的中位时间为 1.8（0.7-4.6）个月：在 ITT 分析中，90.7% 的患者获得了持续病毒学应答 (SVR)，在 PP 分析中，94.7% 的患者获得了持续病毒学应答 (SVR)，在使用的直接作用抗病毒药物 (DAA) 组合方面没有差异。自发治愈率较低，而治疗后的 SVR 达到了 90% 以上。

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引用次数: 0

Anticipating the side effects of benznidazole: HLA-B*35 and patch test 预测苯并咪唑的副作用：HLA-B*35 和斑贴试验

IF 2.6 4区医学 Q3 INFECTIOUS DISEASES

Enfermedades infecciosas y microbiologia clinica

Pub Date : 2024-10-01 DOI: 10.1016/j.eimc.2024.04.006

Introduction

Treatment of Chagas disease frequently causes distress to patients due to a high incidence of adverse effects. Different preemptive tests have been researched to prevent these effects and to allow focus to be given to certain predisposed patients. Benznidazole is the most prescribed Chagas disease treatment in Spain.

In this work, we analyzed the genetic markers HLA-B*35 allele group and HLA-B*35:05 allele specifically, as well as an allergy patch test, as benznidazole's most frequent adverse effects are cutaneous.

Methods

HLA-B intermediate-resolution genotyping was performed followed by a high-resolution level analysis. Cutaneous allergies were tested using strips impregnated with a mixture of benznidazole and placed on the upper back of patients before starting treatment.

Results

In our sample of more than 400 patients, there was almost no relationship between any kind of side effect and either of the HLA-B alleles studied. The patch testing was quickly discarded as a preemptive test due to its low sensitivity (16.7%).

Conclusion

In conclusion, we were unable to replicate and corroborate genetic markers identified by other groups and there is currently no test that can anticipate the adverse effects of benznidazole, therefore, more investigation should be carried out in this field.

导言恰加斯病的治疗由于不良反应发生率高，经常给患者带来痛苦。为了防止这些不良反应，并使某些易感患者得到重点治疗，人们研究了不同的预防性试验。在这项工作中，我们分析了遗传标记 HLA-B*35 等位基因组和 HLA-B*35:05 等位基因，并进行了过敏贴片测试，因为苯并咪唑最常见的不良反应是皮肤过敏。结果在我们抽取的 400 多名患者中，任何一种副作用与所研究的 HLA-B 等位基因之间几乎都没有关系。由于贴片测试的灵敏度较低（16.7%），因此很快就被放弃作为一种预防性测试方法。

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引用次数: 0

Bolas fúngicas en senos paranasales causadas por Syncephalastrum spp.: 2 casos clínicos y revisión de la literatura 由鞘氨醇属真菌引起的窦真菌栓：2 个临床病例和文献综述

IF 2.6 4区医学 Q3 INFECTIOUS DISEASES

Enfermedades infecciosas y microbiologia clinica

Pub Date : 2024-10-01 DOI: 10.1016/j.eimc.2024.05.001

Virginia Cerpa Almenara , Teresa Nebreda Mayoral , María Álvarez Álvarez , Clara Rodrigo Pérez , Natalia Saiz Sigüenza , Maria de la Paz Sánchez Hernández

Introduction

Syncephalastrum spp. is a mucoral that rarely produces pathology. Fungal balls caused by this genus are infrequent. It requires early diagnosis and treatment to avoid associated morbidity and mortality.

Methods

We describe 2 clinical cases of sinus fungus balls caused by Syncephalastrum spp. and review the literature.

Results

Two patients were treated for sinus fungus balls. When their samples were analysed, the aetiology was determined to be Syncephalastrum spp. A case of pulmonary fungus ball due to Syncephalastrum spp. is described in the literature. All cases, including these described in the present study, had a good evolution after treatment.

Conclusions

Syncephalastrum spp. is a filamentous fungus that should be considered as an aetiology of sinus fungus ball.

导言头孢菌属是一种粘菌，很少产生病变。由该菌属引起的真菌球并不常见。方法我们描述了两例由合成头孢菌属引起的鼻窦真菌球的临床病例，并回顾了相关文献。对他们的样本进行分析后，确定病原体为合头菌属。文献中描述了一例由合头菌属引起的肺部真菌球。结论头孢菌属是一种丝状真菌，应被视为鼻窦真菌球的病原体。

{"title":"Bolas fúngicas en senos paranasales causadas por Syncephalastrum spp.: 2 casos clínicos y revisión de la literatura","authors":"Virginia Cerpa Almenara , Teresa Nebreda Mayoral , María Álvarez Álvarez , Clara Rodrigo Pérez , Natalia Saiz Sigüenza , Maria de la Paz Sánchez Hernández","doi":"10.1016/j.eimc.2024.05.001","DOIUrl":"10.1016/j.eimc.2024.05.001","url":null,"abstract":"<div><h3>Introduction</h3><div><em>Syncephalastrum</em> spp. is a mucoral that rarely produces pathology. Fungal balls caused by this genus are infrequent. It requires early diagnosis and treatment to avoid associated morbidity and mortality.</div></div><div><h3>Methods</h3><div>We describe 2clinical cases of sinus fungus balls caused by <em>Syncephalastrum</em> spp<em>.</em> and review the literature.</div></div><div><h3>Results</h3><div>Two patients were treated for sinus fungus balls. When their samples were analysed, the aetiology was determined to be <em>Syncephalastrum</em> spp. A case of pulmonary fungus ball due to <em>Syncephalastrum</em> spp. is described in the literature. All cases, including these described in the present study, had a good evolution after treatment.</div></div><div><h3>Conclusions</h3><div><em>Syncephalastrum</em> spp. is a filamentous fungus that should be considered as an aetiology of sinus fungus ball.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"42 8","pages":"Pages 439-441"},"PeriodicalIF":2.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142420794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sequencing the evolution of vaccinia skin lesions in a laboratory worker: Insights from image analysis 对一名实验室工作人员的疫苗皮损演变过程进行测序：图像分析的启示

IF 2.6 4区医学 Q3 INFECTIOUS DISEASES

Enfermedades infecciosas y microbiologia clinica

Pub Date : 2024-10-01 DOI: 10.1016/j.eimc.2024.04.003

引用次数: 0

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