Enfermedades infecciosas y microbiologia clinica最新文献

英文中文

Implementing CLIA for QuantiFERON®-CMV testing: Optimizing cellular immune response against cytomegalovirus 实施CLIA QuantiFERON®-巨细胞病毒检测：优化细胞免疫应答巨细胞病毒

IF 2.5 4区医学 Q3 INFECTIOUS DISEASES

Enfermedades infecciosas y microbiologia clinica

Pub Date : 2026-01-01 DOI: 10.1016/j.eimc.2025.503050

Juliana Esperalba , Maria Arnedo-Muñoz , Ariadna Rando-Segura , Ibai Los-Arcos , Eva Revilla-López , Aroa Gomez-Brey , Patricia Nadal-Barón , Ester Marquez-Algaba , Víctor Monforte , Alberto Sandiumenge , Nieves Larrosa , Tomàs Pumarola , Oscar Len , Andrés Antón

Introduction

Cytomegalovirus (CMV) remains a significant infectious complication in solid organ transplant recipients. Assessing cellular immunity through interferon-gamma (IFN-γ) release assays, such as QuantiFERON®-CMV (QTF-CMV), is useful for guiding prophylactic and therapeutic decisions. Although ELISA is the validated method for QTF-CMV, chemiluminescence immunoassay (CLIA) may offer technical advantages. This study aimed to evaluate the performance of the CLIA-based LIAISON® QuantiFERON®-TB Gold Plus assay in quantifying IFN-γ in QTF-CMV testing, compared to the ELISA-based QuantiFERON®-CMV assay.

Methods

A retrospective study was conducted on 169 stored plasma samples from 85 lung transplant recipients. IFN-γ was quantified using both ELISA (Qiagen®) and CLIA (DiaSorin®). Specific (CMV-NIL) and nonspecific (MIT-NIL) responses were compared using Pearson and Lin's concordance correlation coefficients, Bland–Altman analysis, and ROC curves. Diagnostic agreement was assessed using the Kappa index, sensitivity, specificity, and agreement rates.

Results

CLIA yielded significantly higher IFN-γ values than ELISA for CMV-NIL (+0.41 IU/mL) and MIT-NIL (+0.33 IU/mL). Strong correlation and concordance were observed (r and ρ_c >0.93). Diagnostic agreement reached 95.86% (Kappa = 0.913), with fewer indeterminate results in CLIA (3.55% vs 4.73%). The optimal CLIA cut-off was 0.2754 IU/mL, achieving 100% sensitivity and specificity compared to ELISA.

Conclusions

CLIA shows excellent agreement with ELISA in QTF-CMV testing and is a reliable and automatable alternative. Its implementation may improve laboratory workflows. Adjusting the cut-off is recommended for optimal diagnostic accuracy.

巨细胞病毒（CMV）仍然是实体器官移植受者中一种重要的感染性并发症。通过干扰素γ (IFN-γ)释放试验评估细胞免疫，如QuantiFERON®-CMV (QTF-CMV)，有助于指导预防和治疗决策。虽然ELISA是QTF-CMV的有效方法，但化学发光免疫分析法（CLIA）可能具有技术优势。本研究旨在评估基于clia的LIAISON®QuantiFERON®-TB Gold Plus法在QTF-CMV检测中定量IFN-γ的性能，并与基于elisa的QuantiFERON®-CMV法进行比较。方法对85例肺移植受者的169份血浆样本进行回顾性分析。采用ELISA （Qiagen®）和CLIA （DiaSorin®）对IFN-γ进行定量。特异性（CMV-NIL）和非特异性（MIT-NIL）反应采用Pearson和Lin’s一致性相关系数、Bland-Altman分析和ROC曲线进行比较。使用Kappa指数、敏感性、特异性和符合率评估诊断一致性。结果sclia检测CMV-NIL （+0.41 IU/mL）和MIT-NIL （+0.33 IU/mL）的IFN-γ值显著高于ELISA。相关性和一致性较强（r和ρc >；0.93）。诊断一致性达到95.86% (Kappa = 0.913)， CLIA的不确定结果较少（3.55% vs 4.73%）。CLIA最佳临界值为0.2754 IU/mL，与ELISA相比，灵敏度和特异性均达到100%。结论sclia与ELISA在QTF-CMV检测中具有良好的一致性，是一种可靠、可自动化的替代方法。它的实施可以改善实验室的工作流程。建议调整截止值以获得最佳诊断准确性。

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引用次数: 0

Enfermedad neumocócica invasiva antes, durante y después de la pandemia de SARS-CoV-2 SARS-CoV-2大流行之前、期间和之后的侵袭性肺炎球菌病

IF 2.5 4区医学 Q3 INFECTIOUS DISEASES

Enfermedades infecciosas y microbiologia clinica

Pub Date : 2026-01-01 DOI: 10.1016/j.eimc.2025.503033

Irati Arregui García , Iñaki Beguiristain , Miguel Fernández-Huerta , Jesús Castilla , María Eugenia Portillo Bordonabe

Background

The aim of this study was to analyse the changes in the incidence of invasive pneumococcal disease (IPD) before, during, and after the SARS-CoV-2 pandemic.

Methods

Cases of IPD detected through active epidemiological surveillance in Navarre, Spain, from 2018 to 2024 were analysed. Incidence rates were compared across three periods: pre-pandemic (2018-2019), pandemic (2020-2022), and post-pandemic (2023-2024) overall and by age groups and serotypes

Results

From 2018 to 2024, a total of 437 IPD cases were diagnosed in Navarre. The incidence of IPD decreased from 11.6 to 5.6 cases per 100,000 persons during the pandemic period and return to 13.0 cases per 100,000 persons in the post-pandemic period. The incidence decreased across all age groups in both, serotypes included and not included in the 13-valent pneumococcal conjugate vaccine (PCV13). Serotype 3 was the most frequent in the three periods, representing 20.3% of all cases. In the post-pandemic period, 35.2% of cases were due to serotypes included in the PCV-13, 45.7% in the PCV-15 and 64.2% in the PCV-20.

Conclusions

During the SARS-CoV-2 pandemic, the incidence of IPD decreased across all age groups for both, PCV13-included and not included serotypes. In the post-pandemic period, incidence returned to pre-pandemic levels. Whole-genome sequencing techniques helped to serotyping of S. pneumoniae, and thus, complemented epidemiological surveillance.

本研究的目的是分析在SARS-CoV-2大流行之前、期间和之后侵袭性肺炎球菌病（IPD）发病率的变化。方法对2018 - 2024年西班牙纳瓦拉地区通过主动流行病学监测发现的IPD病例进行分析。比较了三个时期的发病率：大流行前（2018-2019）、大流行前（2020-2022）和大流行后（2023-2024），并按年龄组和血清类型进行了比较。结果2018年至2024年，纳瓦拉共诊断出437例IPD病例。在大流行期间，IPD的发病率从每10万人11.6例下降到5.6例，在大流行后时期又回到每10万人13.0例。在13价肺炎球菌结合疫苗（PCV13）接种和未接种的两种血清型中，所有年龄组的发病率均有所下降。血清3型在这三个时期最为常见，占所有病例的20.3%。在大流行后时期，35.2%的病例是由于PCV-13、PCV-15和PCV-20中包含的血清型，分别为45.7%和64.2%。结论在SARS-CoV-2大流行期间，包括pcv13和未包括pcv13的血清型在内的所有年龄组IPD发病率均下降。在大流行后时期，发病率恢复到大流行前的水平。全基因组测序技术有助于肺炎链球菌的血清分型，从而补充了流行病学监测。

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引用次数: 0

An exceptional cause of infective endocarditis: Lactobacillus paracasei 感染性心内膜炎的一个特殊原因：副干酪乳杆菌

IF 2.5 4区医学 Q3 INFECTIOUS DISEASES

Enfermedades infecciosas y microbiologia clinica

Pub Date : 2026-01-01 DOI: 10.1016/j.eimc.2025.503031

Antonio Moreno-Flores , Elena García-Campos Losada , Francisco José Vasallo-Vidal , María Teresa Pérez-Rodríguez

引用次数: 0

Outbreak of human external ophthalmomyiasis due to Oestrus ovis in northwestern Spain: Diagnosis, management, and case series 西班牙西北部因卵巢发情引起的人外眼病暴发：诊断、管理和病例系列

IF 2.5 4区医学 Q3 INFECTIOUS DISEASES

Enfermedades infecciosas y microbiologia clinica

Pub Date : 2026-01-01 DOI: 10.1016/j.eimc.2025.503042

Elia de Esteban Maciñeira , Raquel Carracedo , Laura Formoso , Sara Pereira , José Llovo-Taboada , Manuel F. Bande

Introduction

To present a case series of external ophthalmomyiasis caused by Oestrus ovis (L. 1758) (Diptera, Oestridae) larvae over an eight-week period in Santiago de Compostela (NW Spain), highlighting its entomology facts, epidemiological factors, clinical management, and possible complications.

Methods

Five cases were detected at the Ophthalmology Emergency Department of the Hospital Clínico Universitario de Santiago de Compostela. All patients presented with foreign body sensation, tearing, and ocular redness. Larvae were mechanically removed and identified as O. ovis in the L1 larval stage.

Results

Early treatment with larval extraction, antiseptics, and anti-inflammatory agents led to complete resolution without complications. Cases were associated with rural exposure during late summer and early autumn under warm and humid climatic conditions.

Conclusion

External ophthalmomyiasis is an uncommon parasitic zoonosis caused by dipteran larvae, with O. ovis being the most common agent. Accurate diagnosis and early treatment prevent complications. This series highlights the importance of considering climatic and rural exposure factors in endemic areas and suggests the potential impact of climate change on the disease's distribution.

本文报道了西班牙西北部圣地亚哥德孔波斯特拉（Santiago de Compostela） 8周内由卵母鳗（Oestrus ois， L. 1758）（双翅目，卵母鳗科）幼虫引起的一系列外眼病病例，重点介绍了其昆虫学事实、流行病学因素、临床处理和可能的并发症。方法在Clínico圣地亚哥孔波斯特拉大学医院眼科急诊科检查5例。所有患者均有异物感、流泪、眼红肿。在L1幼虫期机械去除幼虫，鉴定为卵圆蚧。结果早期进行幼虫提取、抗菌、抗炎等治疗，完全治愈，无并发症。病例与夏末和初秋温暖潮湿气候条件下的农村暴露有关。结论眼外病是一种罕见的由双翅目昆虫幼虫引起的寄生虫病，以卵圆虫最常见。准确诊断和早期治疗可预防并发症。该系列强调了考虑流行地区气候和农村暴露因素的重要性，并提出了气候变化对疾病分布的潜在影响。

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引用次数: 0

Dengue warning signs persisting post-48 h demand monitoring to avert severe complications 登革热警告信号在48小时后持续存在，需要监测以避免严重并发症

IF 2.5 4区医学 Q3 INFECTIOUS DISEASES

Enfermedades infecciosas y microbiologia clinica

Pub Date : 2026-01-01 DOI: 10.1016/j.eimc.2025.503049

Verónica Andrade-Amaráz, José Pedro Elizalde-Díaz

Introduction

Dengue virus infection remains a major public health challenge in tropical regions, with heterogeneous progression to severe disease.

Methods

We conducted a prospective longitudinal study of 362 laboratory-confirmed dengue patients, stratified by sex and the presence of warning signs. Serial hematological, hepatic and renal markers were collected over 96 h (at 24 h, 48 h, 72 h, and 96 h after symptom onset) to analyze their dynamic evolution.

Results

Patients with warning signs persisting beyond 48 h exhibited progressive hematological and hepatic deterioration, unlike those without warning signs. This was characterized by progressively declining platelet and neutrophil counts, elevated hematocrit, and rising AST/ALT levels. These worsening trends were more pronounced in women, who also showed a higher prevalence of warning signs (32% vs 25% in men).

Conclusion

The persistence of warning signs beyond 48 h represents a clinically relevant threshold for hematological and hepatic deterioration, supporting the need for protocolized monitoring – including serial platelet counts, hematocrit, and liver enzymes – during this critical window to enable early intervention in high-risk patients.

在热带地区，登革热病毒感染仍然是一项重大的公共卫生挑战，发展为严重疾病的过程不尽相同。方法对362例实验室确诊的登革热患者进行了前瞻性纵向研究，按性别和有无警告信号进行分层。在症状出现后24小时、48小时、72小时和96小时收集血液学、肝脏和肾脏的一系列标志物，分析其动态演变。结果有警告信号持续48 h以上的患者与无警告信号的患者不同，其血液学和肝脏功能均出现进行性恶化。其特征是血小板和中性粒细胞计数逐渐下降，红细胞压积升高，AST/ALT水平升高。这些恶化趋势在女性中更为明显，女性也显示出更高的警告信号（32%对25%）。结论警告信号持续超过48小时代表了血液学和肝脏恶化的临床相关阈值，支持在这一关键窗口期进行协议化监测的必要性，包括系列血小板计数、红细胞压积和肝酶，以便对高危患者进行早期干预。

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引用次数: 0

Adecuación del tratamiento de la malaria de acuerdo con los criterios de gravedad definidos por la Organización Mundial de la Salud en un país no endémico 在非疟疾流行国家按照世界卫生组织确定的严重程度标准对疟疾进行适当治疗

IF 2.5 4区医学 Q3 INFECTIOUS DISEASES

Enfermedades infecciosas y microbiologia clinica

Pub Date : 2026-01-01 DOI: 10.1016/j.eimc.2025.503051

María Asunción Pérez-Jacoiste Asín , Andrea Navarro Flores , Anatolio Alonso Crespo , Ana Pérez-Ayala , Irene Losada Galván , Begoña de Dios , Pilar Hernández-Jiménez , Manuel Gil-Mosquera , Francisco Jiménez-Morillas , Carlos Lumbreras , Manuel Lizasoain , Juan María Herrero-Martínez

Introduction

The number of cases of malaria is increasing in Spain due to tourism and migration. Unfamiliarity with this disease may lead doctors to misrecognize its severity and over-/under-treat it. We aimed to analyse the adequacy of treatment according to malaria severity.

Methods

Single-centre retrospective study at “Hospital 12 de Octubre” (Madrid). We identified all patients over 16-years-old with symptomatic malaria from January 2015 to December 2023. The severity of malaria was defined according to WHO criteria. Parenteral artesunate was the treatment of choice for severe malaria. Oral artemisinin combination or atovaquone/proguanil were used for non-severe malaria.

Results

We identified 64 patients (median age 39,5 years (IQR 32,25-47), 75% Visiting Friends and Relatives. Malaria was severe in 15 patients (23.4%). Antimalarial treatment was adequate to severity in 46 patients (71.8%). Three cases classified as severe malaria received oral treatment while 15 cases apparently non-severe received parenteral artesunate. Those who received oral treatment for severe malaria had been misclassified (mild epistaxis, chronic renal insufficiency, and 3.5% parasitaemia in an immigrant). Among those treated parenterally for non-severe malaria, four had oral intolerance and in the remaining eleven, there was an overuse of artesunate. The main reason for artesunate overuse was the presence of thrombocytopenia (median platelet-count: 33,000/mm3, IQR: 28,000-51,000/mm3).

Conclusions

Antimalarial treatments were mostly adequate, especially in severe cases. The most common reason for artesunate overuse was the presence of thrombocytopenia, which is not included in the WHO criteria for severe malaria.

由于旅游和移民，西班牙的疟疾病例数正在增加。对这种疾病的不熟悉可能导致医生错误地认识到其严重性，并对其治疗过度或不足。我们的目的是根据疟疾的严重程度分析治疗的充分性。方法在马德里“10月12日医院”进行单中心回顾性研究。我们确定了2015年1月至2023年12月期间所有16岁以上的有症状疟疾患者。疟疾的严重程度是根据世卫组织的标准确定的。静脉注射青蒿琥酯是治疗严重疟疾的首选方法。非重症疟疾采用口服青蒿素联合用药或阿托伐醌/普罗胍联合用药。结果64例患者，中位年龄39,5岁（IQR 32,25-47）， 75%访亲访友。重症疟疾15例（23.4%）。46例（71.8%）患者抗疟治疗足以缓解严重程度。3例重度疟疾患者接受口服治疗，15例明显非重度疟疾患者接受静脉注射青蒿琥酯治疗。接受口服治疗的重症疟疾患者被错误分类（轻度鼻出血、慢性肾功能不全和移民中3.5%寄生虫血症）。在接受非严重疟疾非肠外治疗的患者中，4人出现口服不耐受，其余11人出现过量使用青蒿琥酯的情况。过量使用青蒿琥酯的主要原因是存在血小板减少（血小板计数中位数：33,000/mm3, IQR: 28,000-51,000/mm3）。结论疟疾治疗大多是充分的，尤其是重症病例。过量使用青蒿琥酯的最常见原因是存在血小板减少症，而世卫组织的严重疟疾标准不包括血小板减少症。

{"title":"Adecuación del tratamiento de la malaria de acuerdo con los criterios de gravedad definidos por la Organización Mundial de la Salud en un país no endémico","authors":"María Asunción Pérez-Jacoiste Asín , Andrea Navarro Flores , Anatolio Alonso Crespo , Ana Pérez-Ayala , Irene Losada Galván , Begoña de Dios , Pilar Hernández-Jiménez , Manuel Gil-Mosquera , Francisco Jiménez-Morillas , Carlos Lumbreras , Manuel Lizasoain , Juan María Herrero-Martínez","doi":"10.1016/j.eimc.2025.503051","DOIUrl":"10.1016/j.eimc.2025.503051","url":null,"abstract":"<div><h3>Introduction</h3><div>The number of cases of malaria is increasing in Spain due to tourism and migration. Unfamiliarity with this disease may lead doctors to misrecognize its severity and over-/under-treat it. We aimed to analyse the adequacy of treatment according to malaria severity.</div></div><div><h3>Methods</h3><div>Single-centre retrospective study at “Hospital 12 de Octubre” (Madrid). We identified all patients over 16-years-old with symptomatic malaria from January 2015 to December 2023. The severity of malaria was defined according to WHO criteria. Parenteral artesunate was the treatment of choice for severe malaria. Oral artemisinin combination or atovaquone/proguanil were used for non-severe malaria.</div></div><div><h3>Results</h3><div>We identified 64 patients (median age 39,5 years (IQR 32,25-47), 75% <em>Visiting Friends and Relatives</em>. Malaria was severe in 15 patients (23.4%). Antimalarial treatment was adequate to severity in 46 patients (71.8%). Three cases classified as severe malaria received oral treatment while 15 cases apparently non-severe received parenteral artesunate. Those who received oral treatment for severe malaria had been misclassified (mild epistaxis, chronic renal insufficiency, and 3.5% parasitaemia in an immigrant). Among those treated parenterally for non-severe malaria, four had oral intolerance and in the remaining eleven, there was an overuse of artesunate. The main reason for artesunate overuse was the presence of thrombocytopenia (median platelet-count: 33,000/mm3, IQR: 28,000-51,000/mm3).</div></div><div><h3>Conclusions</h3><div>Antimalarial treatments were mostly adequate, especially in severe cases. The most common reason for artesunate overuse was the presence of thrombocytopenia, which is not included in the WHO criteria for severe malaria.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"44 1","pages":"Article 503051"},"PeriodicalIF":2.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145950210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Increasing clinical and public health role of Mycobacterium tuberculosis genomics 结核分枝杆菌基因组学在临床和公共卫生中的作用日益增强

IF 2.5 4区医学 Q3 INFECTIOUS DISEASES

Enfermedades infecciosas y microbiologia clinica

Pub Date : 2026-01-01 DOI: 10.1016/j.eimc.2025.503044

Iñaki Comas

引用次数: 0

Reply to “Factors associated with glucocorticoid dosing in treating patients with noncritical COVID-19 pneumonia: Insights from an artificial intelligence-based CT imaging analysis” 回复“糖皮质激素治疗非危重性COVID-19肺炎的相关因素：基于人工智能的CT成像分析”

IF 2.5 4区医学 Q3 INFECTIOUS DISEASES

Enfermedades infecciosas y microbiologia clinica

Pub Date : 2026-01-01 DOI: 10.1016/j.eimc.2025.503046

José Miguel Gómez Verdú , Sergio Alemán Belando

引用次数: 0

Prostatic abscesses as a cause of persistent Staphylococcus aureus bacteremia 前列腺脓肿是引起持续性金黄色葡萄球菌菌血症的原因

IF 2.5 4区医学 Q3 INFECTIOUS DISEASES

Enfermedades infecciosas y microbiologia clinica

Pub Date : 2026-01-01 DOI: 10.1016/j.eimc.2025.503032

Valeria Ferrando-Mérida , Marina Machado , Carmen Cuenca , Rubén Alonso , Patricia Muñoz , Emilio Bouza

Introduction

Persistent Staphylococcus aureus bacteremia (SAB) is associated with high mortality and requires prompt identification and control of the infectious source. Prostatic abscesses, though rare, are an underrecognized cause of persistent SAB, especially in patients with urinary symptoms and comorbidities.

Methods

We present two cases of persistent methicillin-susceptible Staphylococcus aureus (MSSA) bacteremia in which no initial focus was identified despite extensive evaluation. Further investigation led to the diagnosis of prostatic abscesses as the underlying source.

Results

Both patients underwent transurethral drainage of the abscesses in combination with prolonged antibiotic therapy. This combined approach resulted in resolution of the bacteremia and favorable clinical outcomes.

Conclusions

Prostatic abscesses should be considered in the differential diagnosis of persistent SAB, particularly in patients with suggestive urinary symptoms or risk factors. Timely recognition and appropriate source control through surgical drainage and antibiotics are essential for achieving clinical cure.

持续性金黄色葡萄球菌菌血症（SAB）与高死亡率相关，需要及时识别和控制传染源。前列腺脓肿，虽然罕见，是一个未被充分认识的原因，持续SAB，特别是在患者的泌尿系统症状和合并症。方法我们报告了两例持续性甲氧西林敏感金黄色葡萄球菌（MSSA）菌血症，尽管进行了广泛的评估，但未确定最初的焦点。进一步的调查导致诊断前列腺脓肿为潜在的来源。结果两例患者均行经尿道脓肿引流术，并长期应用抗生素治疗。这种联合方法导致了菌血症的解决和良好的临床结果。结论在诊断持续性SAB时应考虑前列腺脓肿，特别是伴有泌尿系统症状或危险因素的患者。及时识别并通过手术引流和抗生素进行适当的源头控制是实现临床治愈的必要条件。

{"title":"Prostatic abscesses as a cause of persistent Staphylococcus aureus bacteremia","authors":"Valeria Ferrando-Mérida , Marina Machado , Carmen Cuenca , Rubén Alonso , Patricia Muñoz , Emilio Bouza","doi":"10.1016/j.eimc.2025.503032","DOIUrl":"10.1016/j.eimc.2025.503032","url":null,"abstract":"<div><h3>Introduction</h3><div>Persistent <em>Staphylococcus aureus</em> bacteremia (SAB) is associated with high mortality and requires prompt identification and control of the infectious source. Prostatic abscesses, though rare, are an underrecognized cause of persistent SAB, especially in patients with urinary symptoms and comorbidities.</div></div><div><h3>Methods</h3><div>We present two cases of persistent methicillin-susceptible <em>Staphylococcus aureus</em> (MSSA) bacteremia in which no initial focus was identified despite extensive evaluation. Further investigation led to the diagnosis of prostatic abscesses as the underlying source.</div></div><div><h3>Results</h3><div>Both patients underwent transurethral drainage of the abscesses in combination with prolonged antibiotic therapy. This combined approach resulted in resolution of the bacteremia and favorable clinical outcomes.</div></div><div><h3>Conclusions</h3><div>Prostatic abscesses should be considered in the differential diagnosis of persistent SAB, particularly in patients with suggestive urinary symptoms or risk factors. Timely recognition and appropriate source control through surgical drainage and antibiotics are essential for achieving clinical cure.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"44 1","pages":"Article 503032"},"PeriodicalIF":2.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145950204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

¿Cómo podemos optimizar el abordaje diagnóstico y terapéutico de la infección de tracto urinario? Una opinión de expertos 我们如何优化尿路感染的诊断和治疗方法？专家意见

IF 2.5 4区医学 Q3 INFECTIOUS DISEASES

Enfermedades infecciosas y microbiologia clinica

Pub Date : 2026-01-01 DOI: 10.1016/j.eimc.2025.503027

Mario Fernández-Ruiz , Rafael San-Juan , María Milagro Montero , José Ramón Paño-Pardo , Jordi Carratalà , Jesús Fortún , Miguel Salavert , Julián Torre-Cisneros , José María Aguado , en representación de los miembros del Grupo OPENIN («Optimización de procesos clínicos para el diagnóstico y tratamiento de infecciones»)

Due to its high incidence, urinary tract infection (UTI) is a common cause of health resources utilization and antibiotic prescription in both outpatient and inpatient settings. The OPENIN («Optimización de procesos clínicos para el diagnóstico y tratamiento de infecciones») Group is composed of Infectious Diseases specialists and Microbiologists and aims at generating recommendations that can contribute to improve the approach to processes with high impact on the health system based on a review of the best available evidence. The second Group meeting (held in October 2024) sought to answer the following questions: Can we optimize the syndromic and microbiological diagnosis of UTI? Is it possible to improve antibiotic treatment practices? And finally, are the different interventions (non-pharmacological measures, antibiotic prophylaxis, bacterial vaccines or probiotics, among others) effective in reducing the risk of recurrences? The present review summarizes the literature scrutinized for that meeting and offers a series of expert recommendations.

尿路感染（UTI）由于其高发病率，是门诊和住院卫生资源利用和抗生素处方的常见原因。OPENIN（«Optimización de procesos clínicos para el diagnóstico y tratamiento de infeciones»）小组由传染病专家和微生物学家组成，旨在根据对现有最佳证据的审查，提出有助于改进对卫生系统有重大影响的过程的方法的建议。第二次小组会议（于2024年10月举行）旨在回答以下问题：我们能否优化尿路感染的综合征和微生物诊断？是否有可能改进抗生素治疗方法？最后，不同的干预措施（非药物措施、抗生素预防、细菌疫苗或益生菌等）是否能有效降低复发风险？本评论总结了为该会议审查的文献，并提出了一系列专家建议。

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