Enfermedades infecciosas y microbiologia clinica最新文献

英文中文

Desafíos y estrategias en la prevención del dengue: un reto para la salud pública 预防登革热的挑战和战略：公共卫生挑战

IF 2.6 4区医学 Q3 INFECTIOUS DISEASES

Enfermedades infecciosas y microbiologia clinica

Pub Date : 2024-10-01 DOI: 10.1016/j.eimc.2024.03.007

引用次数: 0

Recently acquired hepatitis C: Epidemiological characteristics and treatment response in a large cohort of MSM living with HIV in Madrid 新近感染的丙型肝炎：马德里大批感染艾滋病毒的男男性行为者的流行病学特征和治疗反应

IF 2.6 4区医学 Q3 INFECTIOUS DISEASES

Enfermedades infecciosas y microbiologia clinica

Pub Date : 2024-10-01 DOI: 10.1016/j.eimc.2023.06.011

Introduction

We analyzed epidemiological, clinical characteristics, and the response to treatment in people living with HIV (PLHIV) who recently acquired hepatitis C (RAHC) in a multicentre study in Madrid (Spain).

Methods

Multicenter, ambispective, observational study of RAHC in men who have sex with men (MSM) infected with HIV. Clinical, epidemiological, and RAHC evolution were recorded prospectively in 2019 and 2020 and retrospectively in 2017 and 2018. In patients who received HCV treatment, sustained virological response (SVR) was provided 12 weeks after the end of treatment in an intention to treat analysis (ITT): all treated patients were included; and in analysis per-protocol (PP): missing patients were excluded.

Results

Overall, 133 patients were included. Median (IQR) age was 40 (34.3–46.1) years, 90.9% had at least one previous sexual transmission disease (STD), and 33.6% had previously hepatitis C. More than half of the prospective sample included patients using chemsex related drugs (57.3%), 45.7% of them intravenously. The most prevalent genotype was G1a (66.2%), followed by G4 (11.3%). Ten of 90 patients evaluated for spontaneous cure (11%) cured the infection spontaneously, and 119 had treatment after a median time of 1.8 (0.7–4.6) months: sustained virological response (SVR) was achieved in 90.7% in the ITT and 94.7% in the PP analysis, with no differences regarding the direct-acting antiviral agents (DAA) combination used.

Conclusions

MSM infected by HIV with a RAHC were exposed to high-risk sexual behavior. Spontaneous cure rate was low, while SVR after treatment was achieved by more than 90%.

导言：我们在马德里（西班牙）的一项多中心研究中分析了最近感染丙型肝炎（RAHC）的艾滋病病毒感染者（PLHIV）的流行病学、临床特征和治疗反应。2019年和2020年对临床、流行病学和RAHC演变进行了前瞻性记录，2017年和2018年进行了回顾性记录。在接受HCV治疗的患者中，持续病毒学应答（SVR）在治疗结束后12周进行意向治疗分析（ITT）：纳入所有接受治疗的患者；按方案分析（PP）：排除缺失患者。中位（IQR）年龄为 40（34.3-46.1）岁，90.9% 的患者至少曾患一种性传播疾病（STD），33.6% 的患者曾患丙型肝炎。最常见的基因型是 G1a（66.2%），其次是 G4（11.3%）。在接受自发治愈评估的 90 名患者中，有 10 人（11%）自发治愈了感染，119 人在接受治疗后的中位时间为 1.8（0.7-4.6）个月：在 ITT 分析中，90.7% 的患者获得了持续病毒学应答 (SVR)，在 PP 分析中，94.7% 的患者获得了持续病毒学应答 (SVR)，在使用的直接作用抗病毒药物 (DAA) 组合方面没有差异。自发治愈率较低，而治疗后的 SVR 达到了 90% 以上。

{"title":"Recently acquired hepatitis C: Epidemiological characteristics and treatment response in a large cohort of MSM living with HIV in Madrid","authors":"","doi":"10.1016/j.eimc.2023.06.011","DOIUrl":"10.1016/j.eimc.2023.06.011","url":null,"abstract":"<div><h3>Introduction</h3><div>We analyzed epidemiological, clinical characteristics, and the response to treatment in people living with HIV (PLHIV) who recently acquired hepatitis C (RAHC) in a multicentre study in Madrid (Spain).</div></div><div><h3>Methods</h3><div>Multicenter, ambispective, observational study of RAHC in men who have sex with men (MSM) infected with HIV. Clinical, epidemiological, and RAHC evolution were recorded prospectively in 2019 and 2020 and retrospectively in 2017 and 2018. In patients who received HCV treatment, sustained virological response (SVR) was provided 12 weeks after the end of treatment in an intention to treat analysis (ITT): all treated patients were included; and in analysis per-protocol (PP): missing patients were excluded.</div></div><div><h3>Results</h3><div>Overall, 133 patients were included. Median (IQR) age was 40 (34.3–46.1) years, 90.9% had at least one previous sexual transmission disease (STD), and 33.6% had previously hepatitis C. More than half of the prospective sample included patients using <em>chemsex</em> related drugs (57.3%), 45.7% of them intravenously. The most prevalent genotype was G1a (66.2%), followed by G4 (11.3%). Ten of 90 patients evaluated for spontaneous cure (11%) cured the infection spontaneously, and 119 had treatment after a median time of 1.8 (0.7–4.6) months: sustained virological response (SVR) was achieved in 90.7% in the ITT and 94.7% in the PP analysis, with no differences regarding the direct-acting antiviral agents (DAA) combination used.</div></div><div><h3>Conclusions</h3><div>MSM infected by HIV with a RAHC were exposed to high-risk sexual behavior. Spontaneous cure rate was low, while SVR after treatment was achieved by more than 90%.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"42 8","pages":"Pages 414-419"},"PeriodicalIF":2.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127486095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anticipating the side effects of benznidazole: HLA-B*35 and patch test 预测苯并咪唑的副作用：HLA-B*35 和斑贴试验

IF 2.6 4区医学 Q3 INFECTIOUS DISEASES

Enfermedades infecciosas y microbiologia clinica

Pub Date : 2024-10-01 DOI: 10.1016/j.eimc.2024.04.006

Introduction

Treatment of Chagas disease frequently causes distress to patients due to a high incidence of adverse effects. Different preemptive tests have been researched to prevent these effects and to allow focus to be given to certain predisposed patients. Benznidazole is the most prescribed Chagas disease treatment in Spain.

In this work, we analyzed the genetic markers HLA-B*35 allele group and HLA-B*35:05 allele specifically, as well as an allergy patch test, as benznidazole's most frequent adverse effects are cutaneous.

Methods

HLA-B intermediate-resolution genotyping was performed followed by a high-resolution level analysis. Cutaneous allergies were tested using strips impregnated with a mixture of benznidazole and placed on the upper back of patients before starting treatment.

Results

In our sample of more than 400 patients, there was almost no relationship between any kind of side effect and either of the HLA-B alleles studied. The patch testing was quickly discarded as a preemptive test due to its low sensitivity (16.7%).

Conclusion

In conclusion, we were unable to replicate and corroborate genetic markers identified by other groups and there is currently no test that can anticipate the adverse effects of benznidazole, therefore, more investigation should be carried out in this field.

导言恰加斯病的治疗由于不良反应发生率高，经常给患者带来痛苦。为了防止这些不良反应，并使某些易感患者得到重点治疗，人们研究了不同的预防性试验。在这项工作中，我们分析了遗传标记 HLA-B*35 等位基因组和 HLA-B*35:05 等位基因，并进行了过敏贴片测试，因为苯并咪唑最常见的不良反应是皮肤过敏。结果在我们抽取的 400 多名患者中，任何一种副作用与所研究的 HLA-B 等位基因之间几乎都没有关系。由于贴片测试的灵敏度较低（16.7%），因此很快就被放弃作为一种预防性测试方法。

{"title":"Anticipating the side effects of benznidazole: HLA-B*35 and patch test","authors":"","doi":"10.1016/j.eimc.2024.04.006","DOIUrl":"10.1016/j.eimc.2024.04.006","url":null,"abstract":"<div><h3>Introduction</h3><div>Treatment of Chagas disease frequently causes distress to patients due to a high incidence of adverse effects. Different preemptive tests have been researched to prevent these effects and to allow focus to be given to certain predisposed patients. Benznidazole is the most prescribed Chagas disease treatment in Spain.</div><div>In this work, we analyzed the genetic markers HLA-B*35 allele group and HLA-B*35:05 allele specifically, as well as an allergy patch test, as benznidazole's most frequent adverse effects are cutaneous.</div></div><div><h3>Methods</h3><div>HLA-B intermediate-resolution genotyping was performed followed by a high-resolution level analysis. Cutaneous allergies were tested using strips impregnated with a mixture of benznidazole and placed on the upper back of patients before starting treatment.</div></div><div><h3>Results</h3><div>In our sample of more than 400 patients, there was almost no relationship between any kind of side effect and either of the HLA-B alleles studied. The patch testing was quickly discarded as a preemptive test due to its low sensitivity (16.7%).</div></div><div><h3>Conclusion</h3><div>In conclusion, we were unable to replicate and corroborate genetic markers identified by other groups and there is currently no test that can anticipate the adverse effects of benznidazole, therefore, more investigation should be carried out in this field.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"42 8","pages":"Pages 430-434"},"PeriodicalIF":2.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141023662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bolas fúngicas en senos paranasales causadas por Syncephalastrum spp.: 2 casos clínicos y revisión de la literatura 由鞘氨醇属真菌引起的窦真菌栓：2 个临床病例和文献综述

IF 2.6 4区医学 Q3 INFECTIOUS DISEASES

Enfermedades infecciosas y microbiologia clinica

Pub Date : 2024-10-01 DOI: 10.1016/j.eimc.2024.05.001

Virginia Cerpa Almenara , Teresa Nebreda Mayoral , María Álvarez Álvarez , Clara Rodrigo Pérez , Natalia Saiz Sigüenza , Maria de la Paz Sánchez Hernández

Introduction

Syncephalastrum spp. is a mucoral that rarely produces pathology. Fungal balls caused by this genus are infrequent. It requires early diagnosis and treatment to avoid associated morbidity and mortality.

Methods

We describe 2 clinical cases of sinus fungus balls caused by Syncephalastrum spp. and review the literature.

Results

Two patients were treated for sinus fungus balls. When their samples were analysed, the aetiology was determined to be Syncephalastrum spp. A case of pulmonary fungus ball due to Syncephalastrum spp. is described in the literature. All cases, including these described in the present study, had a good evolution after treatment.

Conclusions

Syncephalastrum spp. is a filamentous fungus that should be considered as an aetiology of sinus fungus ball.

导言头孢菌属是一种粘菌，很少产生病变。由该菌属引起的真菌球并不常见。方法我们描述了两例由合成头孢菌属引起的鼻窦真菌球的临床病例，并回顾了相关文献。对他们的样本进行分析后，确定病原体为合头菌属。文献中描述了一例由合头菌属引起的肺部真菌球。结论头孢菌属是一种丝状真菌，应被视为鼻窦真菌球的病原体。

{"title":"Bolas fúngicas en senos paranasales causadas por Syncephalastrum spp.: 2 casos clínicos y revisión de la literatura","authors":"Virginia Cerpa Almenara , Teresa Nebreda Mayoral , María Álvarez Álvarez , Clara Rodrigo Pérez , Natalia Saiz Sigüenza , Maria de la Paz Sánchez Hernández","doi":"10.1016/j.eimc.2024.05.001","DOIUrl":"10.1016/j.eimc.2024.05.001","url":null,"abstract":"<div><h3>Introduction</h3><div><em>Syncephalastrum</em> spp. is a mucoral that rarely produces pathology. Fungal balls caused by this genus are infrequent. It requires early diagnosis and treatment to avoid associated morbidity and mortality.</div></div><div><h3>Methods</h3><div>We describe 2clinical cases of sinus fungus balls caused by <em>Syncephalastrum</em> spp<em>.</em> and review the literature.</div></div><div><h3>Results</h3><div>Two patients were treated for sinus fungus balls. When their samples were analysed, the aetiology was determined to be <em>Syncephalastrum</em> spp. A case of pulmonary fungus ball due to <em>Syncephalastrum</em> spp. is described in the literature. All cases, including these described in the present study, had a good evolution after treatment.</div></div><div><h3>Conclusions</h3><div><em>Syncephalastrum</em> spp. is a filamentous fungus that should be considered as an aetiology of sinus fungus ball.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"42 8","pages":"Pages 439-441"},"PeriodicalIF":2.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142420794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sequencing the evolution of vaccinia skin lesions in a laboratory worker: Insights from image analysis 对一名实验室工作人员的疫苗皮损演变过程进行测序：图像分析的启示

IF 2.6 4区医学 Q3 INFECTIOUS DISEASES

Enfermedades infecciosas y microbiologia clinica

Pub Date : 2024-10-01 DOI: 10.1016/j.eimc.2024.04.003

引用次数: 0

Aspectos epidemiológicos y de manejo clínico relativos a las neumonías diagnosticadas en urgencias en pacientes mayores en España: resultados del estudio EDEN-29 西班牙老年患者在急诊科确诊肺炎的流行病学和临床管理：EDEN-29 研究结果。

IF 2.6 4区医学 Q3 INFECTIOUS DISEASES

Enfermedades infecciosas y microbiologia clinica

Pub Date : 2024-10-01 DOI: 10.1016/j.eimc.2023.10.015

Objectives

To estimate the incidence of pneumonia diagnosis in elderly patients in Spanish emergency departments (ED), need for hospitalization, adverse events and predictive capacity of biomarkers commonly used in the ED.

Methods

Patients ≥ 65 years with pneumonia seen in 52 Spanish EDs were included. We recorded in-hospital and 30-day mortality as adverse events, as well as intensive care unit (ICU) admission among hospitalized patients. Association of 10 predefined variables with adverse events was calculated and expressed as odds ratio (OR) with 95% confidence interval (CI), as well as predictive capacity of 5 commonly used biomarkers in the ED (leukocytes, hemoglobin, C-reactive protein, glucose, creatinine) was investigated using area under the receiver operating characteristic curve (AUC-ROC).

Results

591 patients with pneumonia attended in the ED were included (annual incidence of 18.4 per 1,000 inhabitants). A total of 78% were hospitalized. Overall, 30-day mortality was 14.2% and in-hospital mortality was 12.9%. Functional dependency was associated with both events (OR = 4.453, 95%CI = 2.361-8.400; and OR = 3.497, 95%CI = 1.578- 7.750, respectively) as well as severe comorbidity (2.344, 1.363-4.030, and 2.463, 1.252-4.846, respectively). Admission to the ICU during hospitalization occurred in 3.5%, with no associated factors. The predictive capacity of biomarkers was only moderate for creatinine for ICU admission (AUC-ROC = 0.702, 95%CI = 0.536-0.869) and for leukocytes for post-discharge adverse event (0.669, 0.540-0.798).

Conclusions

Pneumonia is a frequent diagnosis in elderly patients consulting in the ED. Their functional dependence and comorbidity is the most frequent factor associated with adverse events. The biomarkers analyzed do not have a good predictive ability to predict adverse events.

目的估计西班牙急诊科（ED）老年患者肺炎诊断的发生率、住院需求、不良事件以及急诊科常用生物标志物的预测能力。我们记录了作为不良事件的院内死亡率和 30 天死亡率，以及住院患者入住重症监护室（ICU）的情况。我们计算了 10 个预定义变量与不良事件的相关性，并以几率比（OR）和 95% 的置信区间（CI）表示，还使用接收器操作特征曲线下面积（AUC-ROC）研究了急诊室常用的 5 种生物标志物（白细胞、血红蛋白、C 反应蛋白、葡萄糖、肌酐）的预测能力。共有 78% 的患者住院治疗。总体而言，30 天死亡率为 14.2%，住院死亡率为 12.9%。功能依赖性与两种情况（OR = 4.453，95%CI = 2.361-8.400；OR = 3.497，95%CI = 1.578-7.750）以及严重合并症（分别为 2.344，1.363-4.030；2.463，1.252-4.846）有关。住院期间入住重症监护室的比例为 3.5%，没有相关因素。生物标志物对肌酐进入重症监护室（AUC-ROC = 0.702，95%CI = 0.536-0.869）和白细胞出院后不良事件（0.669，0.540-0.798）的预测能力仅为中等。结论肺炎是急诊室就诊的老年患者的常见诊断，其功能依赖性和合并症是与不良事件相关的最常见因素。所分析的生物标志物在预测不良事件方面没有很好的预测能力。

{"title":"Aspectos epidemiológicos y de manejo clínico relativos a las neumonías diagnosticadas en urgencias en pacientes mayores en España: resultados del estudio EDEN-29","authors":"","doi":"10.1016/j.eimc.2023.10.015","DOIUrl":"10.1016/j.eimc.2023.10.015","url":null,"abstract":"<div><h3>Objectives</h3><div>To estimate the incidence of pneumonia diagnosis in elderly patients in Spanish emergency departments (ED), need for hospitalization, adverse events and predictive capacity of biomarkers commonly used in the ED.</div></div><div><h3>Methods</h3><div>Patients ≥65 years with pneumonia seen in 52 Spanish EDs were included. We recorded in-hospital and 30-day mortality as adverse events, as well as intensive care unit (ICU) admission among hospitalized patients. Association of 10 predefined variables with adverse events was calculated and expressed as odds ratio (OR) with 95% confidence interval (CI), as well as predictive capacity of 5 commonly used biomarkers in the ED (leukocytes, hemoglobin, C-reactive protein, glucose, creatinine) was investigated using area under the receiver operating characteristic curve (AUC-ROC).</div></div><div><h3>Results</h3><div>591 patients with pneumonia attended in the ED were included (annual incidence of 18.4 per 1,000 inhabitants). A total of 78% were hospitalized. Overall, 30-day mortality was 14.2% and in-hospital mortality was 12.9%. Functional dependency was associated with both events (OR=4.453, 95%CI=2.361-8.400; and OR=3.497, 95%CI=1.578- 7.750, respectively) as well as severe comorbidity (2.344, 1.363-4.030, and 2.463, 1.252-4.846, respectively). Admission to the ICU during hospitalization occurred in 3.5%, with no associated factors. The predictive capacity of biomarkers was only moderate for creatinine for ICU admission (AUC-ROC=0.702, 95%CI=0.536-0.869) and for leukocytes for post-discharge adverse event (0.669, 0.540-0.798).</div></div><div><h3>Conclusions</h3><div>Pneumonia is a frequent diagnosis in elderly patients consulting in the ED. Their functional dependence and comorbidity is the most frequent factor associated with adverse events. The biomarkers analyzed do not have a good predictive ability to predict adverse events.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"42 8","pages":"Pages 420-429"},"PeriodicalIF":2.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139014636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trend of pediatric leprosy in an endemic area in Northeast of Brazil, 2008–2018 2008-2018年巴西东北部流行区小儿麻风病的发展趋势

IF 2.6 4区医学 Q3 INFECTIOUS DISEASES

Enfermedades infecciosas y microbiologia clinica

Pub Date : 2024-10-01 DOI: 10.1016/j.eimc.2023.06.009

Background

The incidence of leprosy in children is an important indicator of the disease's tendency in the general population and suggests intense circulation and transmission of Mycobacterium leprae.

Objectives

To describe the clinical, epidemiological characteristics and temporal dynamics of leprosy cases in children under 15 years of age from 2008 to 2018 in an endemic municipality.

Methods

A descriptive study with an analytical approach was carried out with data from leprosy cases registered in the Brazilian Information System on Notifiable Diseases for the municipality of Cabo de Santo Agostinho, Pernambuco, Brazil.

Results

Between 2008 and 2018, 112 new cases of leprosy were registered. Most cases were classified as paucibacillary leprosy and occurred in children living in urban areas. There was no significant difference in the incidence of leprosy during the study period. Only 4.5% of the sample presented reactional episodes, but a high number of cases were not evaluated for the occurrence of reactions.

Conclusions

The findings of this study show a high incidence of paucibacillary leprosy in children and adolescents, which reveals active transmission in the community and failures in the detection of new multibacillary cases among adults. Children between 10 and 14 years old are more vulnerable to M. leprae infection and mainly develop paucibacillary leprosy.

背景儿童麻风病的发病率是衡量该病在普通人群中发病趋势的重要指标，表明麻风分枝杆菌的流通和传播十分活跃。目的描述2008年至2018年一个麻风病流行城市中15岁以下儿童麻风病例的临床、流行病学特征和时间动态。方法利用巴西伯南布哥州Cabo de Santo Agostinho市在巴西应报告疾病信息系统中登记的麻风病例数据，采用分析方法开展描述性研究。结果2008年至2018年期间，共登记了112例新的麻风病例。大多数病例被归类为弱荫麻风病，发生在城市地区的儿童身上。研究期间，麻风病发病率没有明显差异。仅有 4.5%的样本出现反应性发作，但有大量病例未对反应的发生进行评估。结论：本研究结果显示，儿童和青少年中的麻风病发病率较高，这表明麻风病在社区中传播活跃，而且未能发现成人中新的多弧菌病例。10至14岁的儿童更容易感染麻风杆菌，并主要发展为弱碱性麻风病。

{"title":"Trend of pediatric leprosy in an endemic area in Northeast of Brazil, 2008–2018","authors":"","doi":"10.1016/j.eimc.2023.06.009","DOIUrl":"10.1016/j.eimc.2023.06.009","url":null,"abstract":"<div><h3>Background</h3><div>The incidence of leprosy in children is an important indicator of the disease's tendency in the general population and suggests intense circulation and transmission of <span><span>Mycobacterium leprae</span></span>.</div></div><div><h3>Objectives</h3><div>To describe the clinical, epidemiological characteristics and temporal dynamics of leprosy cases in children under 15 years of age from 2008 to 2018 in an endemic municipality.</div></div><div><h3>Methods</h3><div>A descriptive study with an analytical approach was carried out with data from leprosy cases registered in the Brazilian Information System on Notifiable Diseases for the municipality of Cabo de Santo Agostinho, Pernambuco, Brazil.</div></div><div><h3>Results</h3><div>Between 2008 and 2018, 112 new cases of leprosy were registered. Most cases were classified as paucibacillary leprosy and occurred in children living in urban areas. There was no significant difference in the incidence of leprosy during the study period. Only 4.5% of the sample presented reactional episodes, but a high number of cases were not evaluated for the occurrence of reactions.</div></div><div><h3>Conclusions</h3><div>The findings of this study show a high incidence of paucibacillary leprosy in children and adolescents, which reveals active transmission in the community and failures in the detection of new multibacillary cases among adults. Children between 10 and 14 years old are more vulnerable to <em>M. leprae</em> infection and mainly develop paucibacillary leprosy.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"42 8","pages":"Pages 401-405"},"PeriodicalIF":2.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134411699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Atypical bullae in hands and trunk: An unusual suspect 手部和躯干的非典型鼓包不寻常的嫌疑人

IF 2.6 4区医学 Q3 INFECTIOUS DISEASES

Enfermedades infecciosas y microbiologia clinica

Pub Date : 2024-10-01 DOI: 10.1016/j.eimc.2023.12.010

引用次数: 0

Spatial analysis for risk assessment of dengue in Spain 西班牙登革热风险评估的空间分析

IF 2.6 4区医学 Q3 INFECTIOUS DISEASES

Enfermedades infecciosas y microbiologia clinica

Pub Date : 2024-10-01 DOI: 10.1016/j.eimc.2023.06.010

Introduction

The establishment of Aedes albopictus in new areas in Europe has changed the risk of local dengue transmission represented by imported human cases. The risk of transmission is determined by the distribution of travelers arriving from dengue-endemic areas and the distribution of Ae. albopictus as potential vectors of dengue in Spain.

Methods

Environmental, entomological, epidemiological, demographic, tourism and travel data were analyzed to produce a series of maps to represent: the distribution of Ae. albopictus across municipalities; the risk of expansion of Ae. albopictus based on a species distribution model; the calculated index of travelers from dengue-endemic areas (IDVZE) per province; the percentage contribution of each municipality to the total number of cases in Spain. The maps were then added using map algebra, to profile the spatial risk of autochthonous dengue in Spain at a municipal level from 2016 to 2018.

Results

Ae. albopictus was detected in 983 municipalities. The calculated IDVZE varied from 0.23 to 10.38, with the highest IDVZE observed in Madrid. The overall risk of autochthonous cases oscillated between 0.234 and 115, with the very high risk and high risk areas detected in the Mediterranean region, mainly in the Levantine coast and some parts of the Balearic Islands. Most of the interior of the peninsula was characterized as low risk.

Conclusion

Prevention and control measures to mitigate the risk of autochthonous dengue should be prioritized for municipalities in the high risk areas integrating early detection of imported dengue cases and vector control.

导言：白纹伊蚊在欧洲新地区的出现改变了由输入性人类病例所代表的登革热在当地传播的风险。传播风险取决于从登革热流行地区来的旅行者的分布情况，以及作为登革热潜在病媒的白纹伊蚊在西班牙的分布情况。白蛉在各市的分布情况；根据物种分布模型得出的白蛉扩展风险；计算得出的各省登革热流行区游客指数（IDVZE）；各市占西班牙病例总数的百分比。然后，利用地图代数将这些地图相加，勾勒出2016年至2018年西班牙市镇一级的自体登革热空间风险。计算得出的 IDVZE 从 0.23 到 10.38 不等，马德里的 IDVZE 最高。自生病例的总体风险在 0.234 至 115 之间波动，在地中海地区发现了极高风险和高风险地区，主要在黎凡特海岸和巴利阿里群岛的部分地区。结论对于高风险地区的城市来说，应优先采取预防和控制措施，以降低自生登革热的风险，其中包括及早发现输入性登革热病例和病媒控制。

{"title":"Spatial analysis for risk assessment of dengue in Spain","authors":"","doi":"10.1016/j.eimc.2023.06.010","DOIUrl":"10.1016/j.eimc.2023.06.010","url":null,"abstract":"<div><h3>Introduction</h3><div>The establishment of <em>Aedes albopictus</em> in new areas in Europe has changed the risk of local dengue transmission represented by imported human cases. The risk of transmission is determined by the distribution of travelers arriving from dengue-endemic areas and the distribution of <em>Ae. albopictus</em> as potential vectors of dengue in Spain.</div></div><div><h3>Methods</h3><div>Environmental, entomological, epidemiological, demographic, tourism and travel data were analyzed to produce a series of maps to represent: the distribution of <em>Ae. albopictus</em> across municipalities; the risk of expansion of <em>Ae. albopictus</em> based on a species distribution model; the calculated index of travelers from dengue-endemic areas (IDVZE) per province; the percentage contribution of each municipality to the total number of cases in Spain. The maps were then added using map algebra, to profile the spatial risk of autochthonous dengue in Spain at a municipal level from 2016 to 2018.</div></div><div><h3>Results</h3><div><em>Ae. albopictus</em> was detected in 983 municipalities. The calculated IDVZE varied from 0.23 to 10.38, with the highest IDVZE observed in Madrid. The overall risk of autochthonous cases oscillated between 0.234 and 115, with the very high risk and high risk areas detected in the Mediterranean region, mainly in the Levantine coast and some parts of the Balearic Islands. Most of the interior of the peninsula was characterized as low risk.</div></div><div><h3>Conclusion</h3><div>Prevention and control measures to mitigate the risk of autochthonous dengue should be prioritized for municipalities in the high risk areas integrating early detection of imported dengue cases and vector control.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"42 8","pages":"Pages 406-413"},"PeriodicalIF":2.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134935912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Consideraciones sobre los comentarios a las recomendaciones del Comité Español del Antibiograma (COESANT) para la realización de los informes de sensibilidad antibiótica acumulada 对西班牙抗生素图谱委员会（COESANT）关于累积抗菌药物药敏性报告建议的意见的考虑

IF 2.6 4区医学 Q3 INFECTIOUS DISEASES

Enfermedades infecciosas y microbiologia clinica

Pub Date : 2024-10-01 DOI: 10.1016/j.eimc.2024.03.011

引用次数: 0

首页上一页

类型

全部化学•材料生命科学医学物理工程技术环境•农林材料科学地球科学法学管理学化学环境科学与生态学计算机科学教育学经济学农林科学人文科学生物学数学物理与天体物理心理学综合性期刊其他工业工程理学历史学农学文学信息工程

数据库

全部 ACS Publications Elsevier ieeexplore Springer The Royal Society of Chemistry Wiley

期刊

Enfermedades infecciosas y microbiologia clinica

全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.

﹀