Pub Date : 2025-12-01DOI: 10.1016/j.eimc.2025.06.017
Cristina Jiménez-Arroyo , Natalia Molinero , Rosa del Campo , Susana Delgado , M. Victoria Moreno-Arribas
Metagenomics has decisively advanced the study of the gut microbiome, enabling a better understanding of its importance for human health. Metataxonomics, based on the sequencing of the 16S rRNA gene, provides taxonomic profiles of prokaryotes, while shotgun metagenomics allows a comprehensive characterization of all DNA present in a sample. With adequate sequencing depth, the latter increases taxonomic resolution to the strain level and provides detailed information on the functional potential of the microbiota. However, the lack of standardization in sample collection and processing, sequencing technologies, and data management limits the comparability of results and their implementation in clinical laboratories. This review offers a practical and updated framework on metagenomic methodologies, data analysis, and the application of artificial intelligence tools, highlighting advances and best practices to facilitate the integration of functional microbiome analysis into clinical practice and to overcome current challenges.
{"title":"Estudio del microbioma intestinal humano mediante metagenómica: avances recientes y desafíos para su implementación clínica","authors":"Cristina Jiménez-Arroyo , Natalia Molinero , Rosa del Campo , Susana Delgado , M. Victoria Moreno-Arribas","doi":"10.1016/j.eimc.2025.06.017","DOIUrl":"10.1016/j.eimc.2025.06.017","url":null,"abstract":"<div><div>Metagenomics has decisively advanced the study of the gut microbiome, enabling a better understanding of its importance for human health. Metataxonomics, based on the sequencing of the 16S rRNA gene, provides taxonomic profiles of prokaryotes, while shotgun metagenomics allows a comprehensive characterization of all DNA present in a sample. With adequate sequencing depth, the latter increases taxonomic resolution to the strain level and provides detailed information on the functional potential of the microbiota. However, the lack of standardization in sample collection and processing, sequencing technologies, and data management limits the comparability of results and their implementation in clinical laboratories. This review offers a practical and updated framework on metagenomic methodologies, data analysis, and the application of artificial intelligence tools, highlighting advances and best practices to facilitate the integration of functional microbiome analysis into clinical practice and to overcome current challenges.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 10","pages":"Pages 698-708"},"PeriodicalIF":2.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145645916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01DOI: 10.1016/j.eimc.2025.06.013
Noelia Parajó Pazos , Alberto Molares-Vila , Maria Jesús Purriños Hermida , Maria Mercedes Treviño Castellano
Background
Toxoplasmosis is an infection caused by Toxoplasma gondii, a globally distributed parasite. In pregnant women, primary infection can lead to congenital toxoplasmosis, resulting in severe birth defects or serious sequelae later in life. The main objective of the present study was to provide epidemiological data on T. gondii infection in pregnant women in our health care area.
Method
We collected the results of T. gondii serology in pregnant women in the health area of our hospital between 2015 and 2022. Both prevalence and incidence were studied. Differences in prevalence and incidence were analysed based on the womeńs age and their area of residence (differentiating between urban and rural areas). The evolution of incidence and prevalence over the years was also examined.
Results
A total of 20,117 pregnant women were included in the study. The prevalence found was 26.98% (5427/20,117), and the incidence was 0.19% (26/13,443). The incidence decreased significantly during the study period, by 34.6% per year, and the prevalence also showed a significant annual decrease of 5.25% since 2018 using Joinpoint regression model. The seroprevalence was significantly higher in women from rural areas and in women above or equal to the median age. Additionally, a subgroup of 379 women from Central and South America was studied, revealing a prevalence of 32.7% (124/379).
Conclusion
Incidence and prevalence of T. gondii have declined significantly in recent years. To guide the implementation of effective gestational screening, it is essential to have up-to-date prevalence and incidence data for different geographical areas of Spain. This will help determine not only the necessity of screening but also the most suitable methods for its implementation.
{"title":"Seroprevalence and incidence of Toxoplasma gondii infection in pregnant women in the health care area of Santiago de Compostela (NW Spain): 2015–2022","authors":"Noelia Parajó Pazos , Alberto Molares-Vila , Maria Jesús Purriños Hermida , Maria Mercedes Treviño Castellano","doi":"10.1016/j.eimc.2025.06.013","DOIUrl":"10.1016/j.eimc.2025.06.013","url":null,"abstract":"<div><h3>Background</h3><div>Toxoplasmosis is an infection caused by <em>Toxoplasma gondii</em>, a globally distributed parasite. In pregnant women, primary infection can lead to congenital toxoplasmosis, resulting in severe birth defects or serious sequelae later in life. The main objective of the present study was to provide epidemiological data on <em>T. gondii</em> infection in pregnant women in our health care area.</div></div><div><h3>Method</h3><div>We collected the results of <em>T. gondii</em> serology in pregnant women in the health area of our hospital between 2015 and 2022. Both prevalence and incidence were studied. Differences in prevalence and incidence were analysed based on the womeńs age and their area of residence (differentiating between urban and rural areas). The evolution of incidence and prevalence over the years was also examined.</div></div><div><h3>Results</h3><div>A total of 20,117 pregnant women were included in the study. The prevalence found was 26.98% (5427/20,117), and the incidence was 0.19% (26/13,443). The incidence decreased significantly during the study period, by 34.6% per year, and the prevalence also showed a significant annual decrease of 5.25% since 2018 using Joinpoint regression model. The seroprevalence was significantly higher in women from rural areas and in women above or equal to the median age. Additionally, a subgroup of 379 women from Central and South America was studied, revealing a prevalence of 32.7% (124/379).</div></div><div><h3>Conclusion</h3><div>Incidence and prevalence of <em>T. gondii</em> have declined significantly in recent years. To guide the implementation of effective gestational screening, it is essential to have up-to-date prevalence and incidence data for different geographical areas of Spain. This will help determine not only the necessity of screening but also the most suitable methods for its implementation.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 10","pages":"Pages 682-687"},"PeriodicalIF":2.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145645914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Transforming long-term care for people with HIV: Movimiento AHORA","authors":"Maria Velasco , Matilde Sanchez-Conde , Julián Olalla , Eugenia Negredo","doi":"10.1016/j.eimc.2025.04.008","DOIUrl":"10.1016/j.eimc.2025.04.008","url":null,"abstract":"","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 10","pages":"Pages 632-635"},"PeriodicalIF":2.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145645471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01DOI: 10.1016/j.eimc.2025.07.007
Cristian Mateo León, Noelia Hernando Parreño, Diego García Martínez de Artola
{"title":"Bacteriemia relacionada con catéter por Brevibacterium casei en un paciente hematológico","authors":"Cristian Mateo León, Noelia Hernando Parreño, Diego García Martínez de Artola","doi":"10.1016/j.eimc.2025.07.007","DOIUrl":"10.1016/j.eimc.2025.07.007","url":null,"abstract":"","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 10","pages":"Pages 721-722"},"PeriodicalIF":2.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145645478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01DOI: 10.1016/j.eimc.2025.06.018
Iker Alonso-González , Maider Zuriarrain-Alonso , Koldo López-Guridi , Paula Lara-Esbrí , Rita Sainz de Rozas , Itxasne Lekue , José Luis Barrios-Andrés
Introduction
With the aim of reducing the number of post-treatment control urine cultures (UC) from health centers in our healthcare area, we conducted an ASP intervention throughout 2022. To do this, we set out to introduce effective methods to quantify, analyze, and subsequently try to reduce the number of inappropiate UC.
Methods
We conducted a prospective and non-restrictive quasi-experimental intervention study with historical and parallel control group to evaluate the impact of the intervention. The UC evaluation was performed by analyzing all the medical records of repeated UC in a period of less than 31 days. UC were classified as: appropriate, inappropriate and doubtful. The study was conducted in 3 phases: phase 1) measurement of the baseline situation; phase 2) intervention in intervention group: simple educational presentations and implementation of a non-restrictive computerized rule, and phase 3) analysis of results in both groups and periods.
Results
Looking at the percentage of appropriate UC, we observed that in the control group there was hardly any variation while in the intervention group these increased by 152.4 (p < 0.001). In addition, in the intervention group there was a decrease in total UCs of 55.4% (n = 418), representing an estimated savings of €7524. The acceptance of the computerized rule in the intervention group was 9.6%.
Conclusions
This ASP intervention is useful in decreasing the number of IUCs, especially the educational presentations. Achieving this can reduce direct and indirect patient harm and healthcare overload, in addition to improving the management of healthcare resources.
{"title":"Impacto de una intervención PROA en la solicitud de urocultivos de control postratamiento en atención primaria","authors":"Iker Alonso-González , Maider Zuriarrain-Alonso , Koldo López-Guridi , Paula Lara-Esbrí , Rita Sainz de Rozas , Itxasne Lekue , José Luis Barrios-Andrés","doi":"10.1016/j.eimc.2025.06.018","DOIUrl":"10.1016/j.eimc.2025.06.018","url":null,"abstract":"<div><h3>Introduction</h3><div>With the aim of reducing the number of post-treatment control urine cultures (UC) from health centers in our healthcare area, we conducted an ASP intervention throughout 2022. To do this, we set out to introduce effective methods to quantify, analyze, and subsequently try to reduce the number of inappropiate UC.</div></div><div><h3>Methods</h3><div>We conducted a prospective and non-restrictive quasi-experimental intervention study with historical and parallel control group to evaluate the impact of the intervention. The UC evaluation was performed by analyzing all the medical records of repeated UC in a period of less than 31 days. UC were classified as: appropriate, inappropriate and doubtful. The study was conducted in 3 phases: phase 1) measurement of the baseline situation; phase 2) intervention in intervention group: simple educational presentations and implementation of a non-restrictive computerized rule, and phase 3) analysis of results in both groups and periods.</div></div><div><h3>Results</h3><div>Looking at the percentage of appropriate UC, we observed that in the control group there was hardly any variation while in the intervention group these increased by 152.4 (p<!--> <!--><<!--> <!-->0.001). In addition, in the intervention group there was a decrease in total UCs of 55.4% (n<!--> <!-->=<!--> <!-->418), representing an estimated savings of €7524. The acceptance of the computerized rule in the intervention group was 9.6%.</div></div><div><h3>Conclusions</h3><div>This ASP intervention is useful in decreasing the number of IUCs, especially the educational presentations. Achieving this can reduce direct and indirect patient harm and healthcare overload, in addition to improving the management of healthcare resources.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 10","pages":"Pages 652-658"},"PeriodicalIF":2.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145645427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nocardia species are opportunistic pathogens with intrinsic antimicrobial resistance and regional variability in susceptibility patterns. Argentina lacks standardized surveillance data, complicating empirical therapy. This study aimed to characterize Nocardia species distribution and antimicrobial resistance profiles nationwide.
Methods
We analyzed 62 clinical Nocardia isolates from 41 laboratories across eight Argentine provinces (2020–2022). Species identification utilized MALDI-TOF mass spectrometry. Antimicrobial susceptibility testing was performed via broth microdilution for 11 antibiotics according to CLSI guidelines, with additional E-test comparisons.
Results
Respiratory specimens predominated (67.7%), followed by central nervous system (14.5%), skin/soft tissue (8.1%), and bloodstream (6.5%) infections. Primary species identified were N. cyriacigeorgica (30.6%), N. abscessus complex (22.6%), and N. farcinica complex (17.7%). Highest susceptibility rates occurred with linezolid (100%) and trimethoprim–sulfamethoxazole (97.6%). Significant resistance was observed for clarithromycin (81.0%), ciprofloxacin (76.2%), and moxifloxacin (57.1%). N. farcinica dominated CNS infections (55.6%), while N. brasiliensis complex prevailed in skin/soft tissue cases (80%). Methodological discrepancies between testing methods showed 33.3% major errors for ceftriaxone (E-test vs. microdilution).
Conclusion
This first Argentine nationwide surveillance study confirms trimethoprim–sulfamethoxazole and linezolid as reliable empiric therapy options while highlighting concerning resistance to fluoroquinolones and macrolides. The observed methodological discordance emphasizes the critical need for standardized antimicrobial susceptibility testing protocols for Nocardia species.
{"title":"Antimicrobial resistance patterns of Nocardia species in clinical isolates from Argentina (2020–2022)","authors":"Mónica Prieto, María Florencia Rocca, Rita Armitano, Ariel Gianecini, Lucía Cipolla","doi":"10.1016/j.eimc.2025.07.003","DOIUrl":"10.1016/j.eimc.2025.07.003","url":null,"abstract":"<div><h3>Introduction</h3><div><em>Nocardia</em> species are opportunistic pathogens with intrinsic antimicrobial resistance and regional variability in susceptibility patterns. Argentina lacks standardized surveillance data, complicating empirical therapy. This study aimed to characterize <em>Nocardia</em> species distribution and antimicrobial resistance profiles nationwide.</div></div><div><h3>Methods</h3><div>We analyzed 62 clinical <em>Nocardia</em> isolates from 41 laboratories across eight Argentine provinces (2020–2022). Species identification utilized MALDI-TOF mass spectrometry. Antimicrobial susceptibility testing was performed via broth microdilution for 11 antibiotics according to CLSI guidelines, with additional E-test comparisons.</div></div><div><h3>Results</h3><div>Respiratory specimens predominated (67.7%), followed by central nervous system (14.5%), skin/soft tissue (8.1%), and bloodstream (6.5%) infections. Primary species identified were <em>N. cyriacigeorgica</em> (30.6%), <em>N. abscessus</em> complex (22.6%), and <em>N. farcinica</em> complex (17.7%). Highest susceptibility rates occurred with linezolid (100%) and trimethoprim–sulfamethoxazole (97.6%). Significant resistance was observed for clarithromycin (81.0%), ciprofloxacin (76.2%), and moxifloxacin (57.1%). <em>N. farcinica</em> dominated CNS infections (55.6%), while <em>N. brasiliensis</em> complex prevailed in skin/soft tissue cases (80%). Methodological discrepancies between testing methods showed 33.3% major errors for ceftriaxone (E-test vs. microdilution).</div></div><div><h3>Conclusion</h3><div>This first Argentine nationwide surveillance study confirms trimethoprim–sulfamethoxazole and linezolid as reliable empiric therapy options while highlighting concerning resistance to fluoroquinolones and macrolides. The observed methodological discordance emphasizes the critical need for standardized antimicrobial susceptibility testing protocols for <em>Nocardia</em> species.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 10","pages":"Pages 659-665"},"PeriodicalIF":2.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145645428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.eimc.2025.01.012
Marta Arsuaga Vicente , Guillermo Ruiz-Carrascoso , Fernando De la Calle-Prieto , Javier Sotillo Gallego , Rosa De Miguel-Buckley , Mar Lago Nuñez , Daniel Mesado Martinez , Marta Díaz Menéndez
Introduction
Schistosomiasis is a neglected tropical disease endemic in 78 countries worldwide. The acute phase, commonly referred to as Katayama fever, is more frequently observed in travelers than in migrants. Despite significant progress in understanding its pathology, many aspects of this disease remain unclear, posing challenges to timely diagnosis and management.
Methods
This observational retrospective study was conducted at the National Referral Unit for Imported Tropical Diseases, located at Hospital La Paz-Carlos III in Madrid, Spain. The study included a total of 14 members of a dance and percussion ensemble that traveled to the Republic of Guinea from March 3 to March 18, 2023. Patients with confirmed or probable schistosomiasis were included in the analysis.
Results
Twelve patients had suspected acute schistosomiasis. Of these, 78.5% were female. The predominant clinical manifestations included fever (91.6%), eosinophilia (100%), acute diarrhea (91.6%), and abdominal pain (83.3%). All patients reported a history of freshwater exposure in Guinea. Schistosoma serology was positive in all cases, and stool samples from five patients revealed the presence of Schistosoma mansoni eggs. Acute symptoms were managed with corticosteroids, leading to clinical improvement in all cases. Thereafter, all patients were treated with praziquantel at a dose of 40 mg/kg/day, administered in two separate doses four weeks apart.
Conclusion
Freshwater exposure in tropical regions is the primary risk factor for acquiring schistosomiasis. Early diagnosis and treatment during the acute phase are crucial to prevent complications and long-term sequelae.
{"title":"Outbreak of Schistosomiasis mansoni in a Spanish dance and percussion ensemble acquired in the Republic of Guinea","authors":"Marta Arsuaga Vicente , Guillermo Ruiz-Carrascoso , Fernando De la Calle-Prieto , Javier Sotillo Gallego , Rosa De Miguel-Buckley , Mar Lago Nuñez , Daniel Mesado Martinez , Marta Díaz Menéndez","doi":"10.1016/j.eimc.2025.01.012","DOIUrl":"10.1016/j.eimc.2025.01.012","url":null,"abstract":"<div><h3>Introduction</h3><div>Schistosomiasis is a neglected tropical disease endemic in 78 countries worldwide. The acute phase, commonly referred to as Katayama fever, is more frequently observed in travelers than in migrants. Despite significant progress in understanding its pathology, many aspects of this disease remain unclear, posing challenges to timely diagnosis and management.</div></div><div><h3>Methods</h3><div>This observational retrospective study was conducted at the National Referral Unit for Imported Tropical Diseases, located at Hospital La Paz-Carlos III in Madrid, Spain. The study included a total of 14 members of a dance and percussion ensemble that traveled to the Republic of Guinea from March 3 to March 18, 2023. Patients with confirmed or probable schistosomiasis were included in the analysis.</div></div><div><h3>Results</h3><div>Twelve patients had suspected acute schistosomiasis. Of these, 78.5% were female. The predominant clinical manifestations included fever (91.6%), eosinophilia (100%), acute diarrhea (91.6%), and abdominal pain (83.3%). All patients reported a history of freshwater exposure in Guinea. Schistosoma serology was positive in all cases, and stool samples from five patients revealed the presence of <em>Schistosoma mansoni</em><span> eggs. Acute symptoms were managed with corticosteroids, leading to clinical improvement in all cases. Thereafter, all patients were treated with praziquantel at a dose of 40</span> <!-->mg/kg/day, administered in two separate doses four weeks apart.</div></div><div><h3>Conclusion</h3><div>Freshwater exposure in tropical regions is the primary risk factor for acquiring schistosomiasis. Early diagnosis and treatment during the acute phase are crucial to prevent complications and long-term sequelae.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 9","pages":"Pages 571-576"},"PeriodicalIF":2.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145425740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.eimc.2025.04.004
Ramón Vela-Fernández, Natalia Montiel Quezel-Guerraz, Teresa Trujillo Soto, Manuel Antonio Rodríguez-Iglesias
{"title":"Cólicos renoureterales de un año de evolución con urocultivos negativos: desafío diagnóstico","authors":"Ramón Vela-Fernández, Natalia Montiel Quezel-Guerraz, Teresa Trujillo Soto, Manuel Antonio Rodríguez-Iglesias","doi":"10.1016/j.eimc.2025.04.004","DOIUrl":"10.1016/j.eimc.2025.04.004","url":null,"abstract":"","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 9","pages":"Pages 618-619"},"PeriodicalIF":2.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145425746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.eimc.2025.05.003
Begoña Fachal Bugarín, Lucía Ramos Merino, Joaquín Manuel Serrano Arreba, Alicia Alonso Álvarez, Ramón María Fernández Varela, Berta Pernas Souto, Laura Gutiérrez Fernández, María Dolores Sousa Regueiro, Enrique Míguez Rey, Efrén Sánchez Vidal
Introduction
Most infections caused by Listeria monocytogenes occur in individuals with predisposing conditions, such as advanced age or the use of immunosuppressive therapies, and primarily manifest as bacteremia or meningoencephalitis. Osteoarticular infections are uncommon and typically affect joint prostheses, with late-onset infections following surgery. Treatment in these cases should include antibiotic therapy along with a surgical strategy, which generally involves the removal of the affected prosthesis.
Methods
Two cases of prosthetic joint infection caused by L. monocytogenes are presented, along with a narrative review of the English and Spanish literature via PubMed® up to December 2024.
Results
To the best of our knowledge, 52 cases of prosthetic joint infection caused by L. monocytogenes have been reported since 2000. All patients had predisposing conditions, with advanced age being the most common (mean age of 71 years). Most cases were late infections following surgery. Combined treatment (antibiotic therapy and surgery) was used in two-thirds of cases. The prognosis was favorable in almost all instances.
Discussion
It is important to consider L. monocytogenes in the etiological diagnosis of prosthetic joint infections, especially in elderly or immunocompromised patients. While the most used antibiotics have been ampicillin and cotrimoxazole, oxazolidinones could serve as an oral alternative for the treatment of these infections.
{"title":"Infección de prótesis articular por Listeria monocytogenes: a propósito de 2 casos clínicos y revisión de la literatura","authors":"Begoña Fachal Bugarín, Lucía Ramos Merino, Joaquín Manuel Serrano Arreba, Alicia Alonso Álvarez, Ramón María Fernández Varela, Berta Pernas Souto, Laura Gutiérrez Fernández, María Dolores Sousa Regueiro, Enrique Míguez Rey, Efrén Sánchez Vidal","doi":"10.1016/j.eimc.2025.05.003","DOIUrl":"10.1016/j.eimc.2025.05.003","url":null,"abstract":"<div><h3>Introduction</h3><div>Most infections caused by <em>Listeria monocytogenes</em> occur in individuals with predisposing conditions, such as advanced age or the use of immunosuppressive therapies, and primarily manifest as bacteremia or meningoencephalitis. Osteoarticular infections are uncommon and typically affect joint prostheses, with late-onset infections following surgery. Treatment in these cases should include antibiotic therapy along with a surgical strategy, which generally involves the removal of the affected prosthesis.</div></div><div><h3>Methods</h3><div>Two cases of prosthetic joint infection caused by <em>L. monocytogenes</em> are presented, along with a narrative review of the English and Spanish literature via PubMed® up to December 2024.</div></div><div><h3>Results</h3><div>To the best of our knowledge, 52 cases of prosthetic joint infection caused by <em>L. monocytogenes</em> have been reported since 2000. All patients had predisposing conditions, with advanced age being the most common (mean age of 71 years). Most cases were late infections following surgery. Combined treatment (antibiotic therapy and surgery) was used in two-thirds of cases. The prognosis was favorable in almost all instances.</div></div><div><h3>Discussion</h3><div>It is important to consider <em>L. monocytogenes</em> in the etiological diagnosis of prosthetic joint infections, especially in elderly or immunocompromised patients. While the most used antibiotics have been ampicillin and cotrimoxazole, oxazolidinones could serve as an oral alternative for the treatment of these infections.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 9","pages":"Pages 591-595"},"PeriodicalIF":2.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145425687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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