Enfermedades infecciosas y microbiologia clinica最新文献

英文中文

Regional and sex differences in infective endocarditis mortality in Spain 西班牙感染性心内膜炎死亡率的地区和性别差异

IF 2.5 4区医学 Q3 INFECTIOUS DISEASES

Enfermedades infecciosas y microbiologia clinica

Pub Date : 2026-01-01 DOI: 10.1016/j.eimc.2025.503057

Lucía Cayuela , Clara Peiró Villalba , Beatriz Valle Borrego , Aurelio Cayuela

Introduction

This study aimed to describe national and regional trends in infective endocarditis (IE) mortality in Spain.

Methods

This ecological study analyzed IE mortality trends in Spain from 1999 to 2023 using data from the Spanish National Institute of Statistics. Age-standardized mortality rates (ASMRs) were calculated using direct standardization to the 2013 European Standard Population. Joinpoint regression analysis identified significant shifts in trend trajectories, calculating Annual Percentage Change (APC) and Average Annual Percent Change (AAPC). Regional disparities were assessed using Standardized Mortality Ratios (SMRs) for 2023.

Results

Between 1999 and 2023, 29,766 IE deaths occurred in Spain; 58.0% were women, and 89.0% were aged ≥65 years. Men's ASMR increased from 2.46 to 2.95 per 100,000 (AAPC: +1.2%), showing significant rise from 1999 to 2010 (APC: +2.1%) followed by stabilization. Conversely, women's ASMR declined from 2.60 to 2.00 per 100,000 (AAPC: −0.5%), with initial increase (1999–2017, APC: +0.9%) followed by marked decline (2017–2023, APC: −4.9%).

Regional variations were notable. Among men, Galicia (AAPC: +3.7%) and Asturias (+3.4%) showed steepest increases, while Castile and León declined (−3.0%). In 2023, Navarre (SMR: 2.01) and Galicia (SMR: 1.93) had nearly double national IE mortality risk. For women, Galicia had most pronounced increase (AAPC: 4.1%), while significant declines occurred in Castile and León (AAPC: −4.1%). In 2023, Navarre (SMR: 2.46) and Galicia (SMR: 2.00) exhibited significantly elevated mortality.

Conclusions

IE mortality in Spain exhibits complex sex-specific trends and persistent regional disparities, underscoring the need for targeted, equitable public health interventions.

本研究旨在描述西班牙感染性心内膜炎（IE）死亡率的国家和地区趋势。方法本生态学研究利用西班牙国家统计局的数据分析了1999年至2023年西班牙IE死亡率趋势。年龄标准化死亡率（ASMRs）采用2013年欧洲标准人口的直接标准化计算。结合点回归分析确定了趋势轨迹的显著变化，计算了年变化百分比（APC）和平均年变化百分比（AAPC）。使用2023年的标准化死亡率（SMRs）评估区域差异。结果1999年至2023年间，西班牙发生了29,766例IE死亡；58.0%为女性，89.0%年龄≥65岁。男性ASMR从2.46 / 10万增加到2.95 / 10万（AAPC: +1.2%），从1999年到2010年显著上升（APC: +2.1%），随后趋于稳定。相反，女性的ASMR从2.60 / 10万下降到2.00 / 10万（AAPC: - 0.5%），先是上升（1999-2017年，APC: +0.9%），然后明显下降（2017-2023年，APC: - 4.9%）。地区差异显著。在男性中，加利西亚（AAPC: +3.7%）和阿斯图里亚斯（+3.4%）增长最快，而卡斯蒂利亚和León则下降了（- 3.0%）。2023年，纳瓦拉（SMR: 2.01）和加利西亚（SMR: 1.93）的IE死亡率几乎是全国IE死亡率的两倍。对于女性来说，加利西亚的增长最为明显（AAPC: 4.1%），而卡斯蒂利亚和León的下降最为明显（AAPC: - 4.1%）。2023年，纳瓦拉（SMR: 2.46）和加利西亚（SMR: 2.00）的死亡率显著升高。结论：西班牙的sie死亡率呈现出复杂的性别趋势和持续的地区差异，强调需要有针对性、公平的公共卫生干预措施。

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引用次数: 0

Absceso hepático amebiano tras las inundaciones ocasionadas por la DANA de octubre de 2024 en Valencia, España: un caso centinela de riesgo parasitario emergente en entornos no endémicos 西班牙瓦伦西亚2024年10月DANA洪灾后阿米巴肝脓肿：非地方病环境中出现寄生虫风险的一个哨点病例

IF 2.5 4区医学 Q3 INFECTIOUS DISEASES

Enfermedades infecciosas y microbiologia clinica

Pub Date : 2026-01-01 DOI: 10.1016/j.eimc.2025.503034

Javier García-Abellán, Mar Masiá, Félix Gutiérrez

引用次数: 0

Pericarditis aguda por Listeria monocytogenes en un paciente inmunocompetente 免疫能力患者单核细胞增生李斯特菌引起的急性心包炎

IF 2.5 4区医学 Q3 INFECTIOUS DISEASES

Enfermedades infecciosas y microbiologia clinica

Pub Date : 2026-01-01 DOI: 10.1016/j.eimc.2025.503058

Rodrigo Puga López , Ricardo Fernández-Rodríguez , Raquel Fernández González

引用次数: 0

Desenmascarando al patógeno oculto: hemólisis masiva y sepsis fulminante 揭露隐藏的病原体：大规模溶血和快速败血症

IF 2.5 4区医学 Q3 INFECTIOUS DISEASES

Enfermedades infecciosas y microbiologia clinica

Pub Date : 2026-01-01 DOI: 10.1016/j.eimc.2025.503043

Carmen Frías Ruiz , Gema García de la Rosa , Noelia Hernando Parreño , Francisco Martínez Bugallo

引用次数: 0

Identificación de linajes y sublinajes del complejo Mycobacterium tuberculosis mediante estrategias moleculares avanzadas y secuenciación en Sevilla, España (2015-2022) 在西班牙塞维利亚使用先进的分子策略和测序鉴定结核分枝杆菌复合体的谱系和亚分支（2015-2022年）

IF 2.5 4区医学 Q3 INFECTIOUS DISEASES

Enfermedades infecciosas y microbiologia clinica

Pub Date : 2026-01-01 DOI: 10.1016/j.eimc.2025.503038

María Aznar , Mariana G. López , María José Torres , Eduardo Briones , Juan Francisco Medina , Verónica González-Galán

Introduction

Tuberculosis (TB) in the Virgen del Rocío university hospital health area, included in the Seville Health District, Spain, exceeds the rate of 17 cases/100,000 inhabitants. Within the Mycobacterium tuberculosis complex (MTBC), M. tuberculosis sensu stricto comprises seven phylogenetic lineages (L1-L4 and L7-L9). The objective of this work is to know the circulating lineages in the area.

Methods

Molecular typing and sequencing were performed to identify circulating lineages from 2015 to 2022.

Results

From 2015 to 2019, the following were identified: L4 (95.95%, n = 355), L2 (1.62%, n = 6), and L6 (1.08%, n = 4). From 2020-2022: L4 94.62% (n = 123); L1 1.5% (n = 2); L3 1.5% (n = 2) and L2 0.76% (n = 1).

Conclusions

The emergence of different lineages in our area and their recognition are key to contributing to disease control. These findings demonstrate the need to continue surveillance and apply sequencing to understand and control the dynamics of TB transmission.

在西班牙塞维利亚卫生区所属的Rocío大学医院卫生区，结核病发病率超过每10万居民17例。在结核分枝杆菌复合体（MTBC）中，严格意义结核分枝杆菌包括7个系统发育谱系（L1-L4和L7-L9）。这项工作的目的是了解该地区的流通血统。方法采用分子分型和测序方法鉴定2015 - 2022年的循环谱系。结果2015 - 2019年共鉴定出L4 （95.95%, n = 355）、L2 （1.62%, n = 6）、L6 （1.08%, n = 4）。2020-2022年：L4 94.62% (n = 123)；L1 1.5% (n = 2)；L3 1.5% (n = 2), L2 0.76% （n = 1）。结论本地区不同谱系的出现和识别是控制疾病的关键。这些发现表明，需要继续进行监测并应用测序来了解和控制结核传播的动态。

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Pérdida de agudeza visual en paciente con antecedentes de infección ocular: un desafío diagnóstico y terapéutico 有眼部感染史的患者视力下降：一项诊断和治疗挑战

IF 2.5 4区医学 Q3 INFECTIOUS DISEASES

Enfermedades infecciosas y microbiologia clinica

Pub Date : 2026-01-01 DOI: 10.1016/j.eimc.2025.503048

Mario Villarreal-Lopez de Munain , Mikel del Álamo Martínez de Lagos , Alejandro Fonollosa , Josune Goikoetxea Aguirre

引用次数: 0

Acute Q fever in Spain: Aligning diagnosis and one health surveillance 西班牙急性Q热：统一诊断和健康监测

IF 2.5 4区医学 Q3 INFECTIOUS DISEASES

Enfermedades infecciosas y microbiologia clinica

Pub Date : 2025-12-01 DOI: 10.1016/j.eimc.2025.08.001

Francisco Carmona-Torre, Maialen Ibarguren Pinilla, Miguel Ángel Goenaga

引用次数: 0

The current challenge of accurately diagnosing new HIV infections 当前的挑战是准确诊断新的艾滋病毒感染

IF 2.5 4区医学 Q3 INFECTIOUS DISEASES

Enfermedades infecciosas y microbiologia clinica

Pub Date : 2025-12-01 DOI: 10.1016/j.eimc.2025.07.005

Sergio Fuente-García , Laura Martínez-García , Ana Moreno , Juan Carlos Galán

引用次数: 0

Fibrosis mediastínica como complicación de la infección por Histoplasma capsulatum en paciente inmunocomprometida 作为免疫受损患者囊性组织质感染并发症的介质纤维化

IF 2.5 4区医学 Q3 INFECTIOUS DISEASES

Enfermedades infecciosas y microbiologia clinica

Pub Date : 2025-12-01 DOI: 10.1016/j.eimc.2025.05.007

Susana Laura García Aguilera , Beatriz Villar Navas , Alba Mohedano Sánchez , Nerea Mohino Farré

引用次数: 0

Fiebre Q aguda en Mallorca, 2017-2022. Un problema infraestimado 2017-2022年马略卡岛急性Q热。被低估的问题

IF 2.5 4区医学 Q3 INFECTIOUS DISEASES

Enfermedades infecciosas y microbiologia clinica

Pub Date : 2025-12-01 DOI: 10.1016/j.eimc.2025.01.004

Mercedes García-Gasalla , Sophia Pinecki Socias , Pablo A. Fraile , Victoria Fernández-Baca , Aroa Villoslada , Antonio Adrover , Sandra Gregorio , Marta González-Moreno , Alfredo Pinheiro Martins , Alexander Zidouh , Gemma Mut , Meritxell Gavaldà , Melchor Riera , Luisa Martín Pena , Javier Murillas Angoiti

Introduction

Q fever (QF) is a zoonotic infection caused by Coxiella burnetii. Previous studies suggest that the incidence in the island of Majorca may be high. The objective was to know the epidemiological, clinical, diagnostic, and therapeutic characteristics of acute QF (AQF) on the island of Majorca during the years 2017 to 2022.

Methods

Retrospective analysis of a series of cases of AQF diagnosed in 3 out 4 hospitals of the Health Service of the island of Majorca. AQF was considered if a clinically compatible syndrome was present with one of the following serological criteria: confirmed AQF if IgG seroconversion phase II, very possible if only IgG ≥ 1/128 is available in addition to a positive IgM, and AQF possible if IgG ≥ 1/512 with negative IgM or if IgM positive with negative IgG in a single serological determination.

Results

223 cases of AQF were diagnosed, of which 102 (45.7%) were confirmed, 84 (37.7%) very possible and 37 (16.6%) possible AQF. Prolonged febrile syndrome was the most frequent clinical diagnosis (107, 48.0%), followed by pneumonia with/without pleural effusion (49, 21.9%), acute hepatitis (38, 17.0%), pericarditis and/or myocarditis (6, 2.6%). Three patients developed endocarditis (one in the acute phase, two others during follow-up). The median number of cases per year was 34 (p25-p75: 31.7 - 40.25). AQF-related mortality was 1.8% (4 patients).

Conclusion

AQF is a preventable and little recognized zoonosis, causing significant morbidity and mortality in Majorca.

q热是一种由伯纳克希菌引起的人畜共患感染。先前的研究表明，马略卡岛的发病率可能很高。目的是了解2017年至2022年马略卡岛急性QF （AQF）的流行病学、临床、诊断和治疗特征。方法回顾性分析马略卡岛卫生服务部门4所医院中3所诊断的一系列AQF病例。如果临床相容综合征存在以下血清学标准之一，则考虑AQF：如果IgG血清转化期为确诊AQF，如果IgG≥1/128且IgM阳性，则极有可能，如果IgG≥1/512且IgM阴性或IgM阳性且IgG阴性，则AQF可能。结果确诊AQF 223例，确诊102例（45.7%），非常可能84例（37.7%），可能37例（16.6%）。延长热综合征是最常见的临床诊断（107例，48.0%），其次是肺炎合并/不合并胸腔积液（49例，21.9%），急性肝炎（38例，17.0%），心包炎和/或心肌炎（6例，2.6%）。3例患者发生心内膜炎（1例急性期，2例随访）。每年中位病例数为34例（p25-p75: 31.7 - 40.25）。aqf相关死亡率为1.8%（4例）。结论马略卡岛aqf是一种可预防的人畜共患疾病，发病率和死亡率均较高。

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