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The incubation for urethral gonorrhoea among men who have sex with men with and without oropharyngeal gonorrhoea. 有口咽淋病和无口咽淋病的男男性行为者中尿道淋病的潜伏期。
IF 2.5 4区 医学 Q3 INFECTIOUS DISEASES Pub Date : 2024-09-27 DOI: 10.1017/S095026882400089X
Julien Tran, Christopher K Fairley, Jason J Ong, Tiffany R Phillips, Ei T Aung, Eric P F Chow

We hypothesized that the incubation for urethral gonorrhoea would be longer for men with oropharyngeal gonorrhoea than those without oropharyngeal gonorrhoea. We conducted a chart review of men who have sex with men with urethral gonorrhoea symptoms at a sexual health clinic between 2019 and 2021. The incubation period was defined as the number of days between men's last sexual contact and onset of symptoms. We used a Mann-Whitney U test to compare differences in the median incubation for urethral gonorrhoea between men with and men without oropharyngeal gonorrhoea. There were 338 men with urethral symptoms (median age = 32 years; IQR: 28-39), and of these, 307 (90.1%) were tested for oropharyngeal gonorrhoea, of whom 124 (40.4%, 95% CI: 34.9-46.1) men had oropharyngeal and urethral gonorrhoea. We analyzed incubation data available for 190 (61.9%) of the 307 men, with 38.9% (74/190) testing positive for oropharyngeal gonorrhoea. The incubation for urethral gonorrhoea did not differ between 74 men (39%) with oropharyngeal gonorrhoea (median = 4 days; IQR: 2-6) and 116 men (61%) without oropharyngeal gonorrhoea (median = 2.5 days; IQR: 1-5) (p = 0.092). Research is needed to investigate gonorrhoea transmission from the oropharynx to the urethra.

我们假设,与没有口咽部淋病的男性相比,患有口咽部淋病的男性的尿道淋病潜伏期会更长。我们对 2019 年至 2021 年期间在性健康诊所就诊的有尿道淋病症状的男男性行为者进行了病历审查。潜伏期定义为男性最后一次性接触与症状出现之间的天数。我们使用 Mann-Whitney U 检验来比较患有和未患有口咽部淋病的男性之间尿道淋病潜伏期中位数的差异。共有 338 名男性出现尿道症状(中位年龄 = 32 岁;IQR:28-39),其中 307 人(90.1%)接受了口咽淋病检测,其中 124 人(40.4%,95% CI:34.9-46.1)同时患有口咽部淋病和尿道淋病。我们分析了 307 名男性中 190 人(61.9%)的潜伏期数据,其中 38.9%(74/190)的口咽淋病检测呈阳性。74名患有口咽部淋病的男性(39%)(中位数=4天;IQR:2-6)与116名没有口咽部淋病的男性(61%)(中位数=2.5天;IQR:1-5)的尿道淋病潜伏期没有差异(p=0.092)。需要对淋病从口咽传播到尿道的情况进行研究。
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引用次数: 0
Omicron incidence and seroprevalence among children in Montreal, Canada, in early 2023: final results from the longitudinal EnCORE serology study. 2023 年初加拿大蒙特利尔儿童的奥米克原发病率和血清流行率:EnCORE 血清学纵向研究的最终结果。
IF 2.5 4区 医学 Q3 INFECTIOUS DISEASES Pub Date : 2024-09-25 DOI: 10.1017/S0950268824000797
Katia Charland, Laura Pierce, Adrien Saucier, Marie-Ève Hamelin, Margot Barbosa Da Torre, Julie Carbonneau, Cat Tuong Nguyen, Gaston De Serres, Jesse Papenburg, Guy Boivin, Caroline Quach, Kate Zinszer

Since early 2022, routine testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) based on symptoms and exposure history has largely ceased in Canada. Consequently, seroprevalence studies, particularly longitudinal studies, have become critical for monitoring the rate of incident SARS-CoV-2 infections and the proportion of the population with evidence of immunity. EnCORE is a longitudinal SARS-CoV-2 seroprevalence study comprising five rounds of serology testing from October 2020 to June 2023, in a sample of 2- to 17-year-olds (at baseline), recruited from daycares and schools in four neighbourhoods of Montreal, Canada. We report on SARS-CoV-2 incidence and seroprevalence among the 509 participants in the fifth and final round of the study. Seroprevalence of antibodies from either infection or vaccination was 98% (95 per cent confidence interval [CI]: 97, 99). The infection-acquired seroprevalence was 78% (95% CI: 73-82), and the incidence rate was 113 per 100 person-years (95% CI: 94-132), compared to the seroprevalence of 58% and the incidence rate of 133 per 100 person-years, respectively, in the fourth round of testing (mid-late 2022). Of the 131 participants newly seropositive for infection in Round 4, only 18 were seronegative for infection in Round 5 (median follow-up: 326 days).

自 2022 年初以来,加拿大基本停止了基于症状和接触史的严重急性呼吸系统综合症冠状病毒 2(SARS-CoV-2)常规检测。因此,血清流行率研究,尤其是纵向研究,对于监测 SARS-CoV-2 感染率和有免疫证据的人口比例至关重要。EnCORE 是一项纵向 SARS-CoV-2 血清流行率研究,从 2020 年 10 月到 2023 年 6 月,对加拿大蒙特利尔四个社区的托儿所和学校招募的 2 至 17 岁儿童样本(基线)进行了五轮血清学检测。我们报告了第五轮也是最后一轮研究中 509 名参与者的 SARS-CoV-2 发病率和血清流行率。感染或接种疫苗产生的抗体血清阳性率为 98%(95% 置信区间 [CI]:97, 99)。感染获得的血清流行率为78%(95% CI:73-82),发病率为每百人年113例(95% CI:94-132),而第四轮检测(2022年中后期)的血清流行率和发病率分别为每百人年58%和133例。在第四轮检测中血清反应呈阳性的 131 名参与者中,只有 18 人在第五轮检测中血清反应呈阴性(中位数随访时间:326 天)。
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引用次数: 0
Severe acute respiratory syndrome coronavirus 2-reactive salivary antibody detection in South Carolina emergency healthcare workers, September 2019-March 2020. 2019 年 9 月至 2020 年 3 月,在南卡罗来纳州急诊医护人员中检测严重急性呼吸系统综合征冠状病毒 2 反应性唾液抗体。
IF 2.5 4区 医学 Q3 INFECTIOUS DISEASES Pub Date : 2024-09-25 DOI: 10.1017/S0950268824000967
Haley C Meltzer, Jane L Goodwin, Lauren A Fowler, Thomas W Britt, Ronald G Pirrallo, Jennifer T Grier

On 19 January 2020, the first case of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection was identified in the United States, with the first cases in South Carolina confirmed on 06 March 2020. Due to initial limited testing capabilities and potential for asymptomatic transmission, it is possible that SARS-CoV-2 may have been present earlier than previously thought, while the immune status of at-risk populations was unknown. Saliva from 55 South Carolina emergency healthcare workers (EHCWs) was collected from September 2019 to March 2020, pre- and post-healthcare shifts, and stored frozen. To determine the presence of SARS-CoV-2-reactive antibodies, saliva-acquired post-shift was analysed by enzyme-linked immunosorbent assay (ELISA) with a repeat of positive or inconclusive results and follow-up testing of pre-shift samples. Two participants were positive for SARS-CoV-2 N/S1-reactive IgG, confirmed by follow-up testing, with S1 receptor binding domain (RBD)-specific IgG present in one individual. Positive samples were collected from medical students working in emergency medical services (EMSs) in October or November 2019. The presence of detectable anti-SARS-CoV-2 antibodies in 2019 suggests that immune responses to the virus existed in South Carolina, and the United States, in a small percentage of EHCWs prior to the earliest documented coronavirus disease 2019 (COVID-19) cases. These findings suggest the feasibility of saliva as a noninvasive tool for surveillance of emerging outbreaks, and EHCWs represent a high-risk population that should be the focus of infectious disease surveillance.

2020 年 1 月 19 日,美国发现首例严重急性呼吸系统综合征冠状病毒 2(SARS-CoV-2)感染病例,2020 年 3 月 6 日南卡罗来纳州确诊首例病例。由于最初的检测能力有限以及可能存在无症状传播,SARS-CoV-2 有可能比以前认为的更早出现,而高危人群的免疫状况尚不清楚。从 2019 年 9 月到 2020 年 3 月,我们收集了 55 名南卡罗来纳州急诊医护人员(EHCWs)在医护人员轮班前和轮班后的唾液,并将其冷冻保存。为了确定是否存在 SARS-CoV-2 反应性抗体,采用酶联免疫吸附试验(ELISA)对轮班后获得的唾液进行了分析,并对阳性或不确定的结果进行了复查,同时对轮班前的样本进行了后续检测。两名参与者的 SARS-CoV-2 N/S1 反应 IgG 呈阳性,并经后续检测证实,其中一人的 S1 受体结合域(RBD)特异性 IgG 呈阳性。阳性样本采集自 2019 年 10 月或 11 月在急诊医疗服务机构(EMS)工作的医学生。2019 年出现可检测到的抗 SARS-CoV-2 抗体表明,在最早记录在案的 2019 年冠状病毒病(COVID-19)病例之前,南卡罗来纳州和美国的一小部分急诊医疗工作者对该病毒存在免疫反应。这些研究结果表明,将唾液作为监测新发疫情的非侵入性工具是可行的,EHCW代表着高风险人群,应成为传染病监测的重点。
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引用次数: 0
Surveillance of SARS-CoV-2 prevalence from repeated pooled testing: application to Swiss routine data. 通过重复联合检测监测 SARS-CoV-2 流行情况:应用于瑞士常规数据。
IF 2.5 4区 医学 Q3 INFECTIOUS DISEASES Pub Date : 2024-08-22 DOI: 10.1017/S0950268824000876
Julien Riou, Erik Studer, Anna Fesser, Tobias Magnus Schuster, Nicola Low, Matthias Egger, Anthony Hauser

Surveillance of SARS-CoV-2 through reported positive RT-PCR tests is biased due to non-random testing. Prevalence estimation in population-based samples corrects for this bias. Within this context, the pooled testing design offers many advantages, but several challenges remain with regards to the analysis of such data. We developed a Bayesian model aimed at estimating the prevalence of infection from repeated pooled testing data while (i) correcting for test sensitivity; (ii) propagating the uncertainty in test sensitivity; and (iii) including correlation over time and space. We validated the model in simulated scenarios, showing that the model is reliable when the sample size is at least 500, the pool size below 20, and the true prevalence below 5%. We applied the model to 1.49 million pooled tests collected in Switzerland in 2021-2022 in schools, care centres, and workplaces. We identified similar dynamics in all three settings, with prevalence peaking at 4-5% during winter 2022. We also identified differences across regions. Prevalence estimates in schools were correlated with reported cases, hospitalizations, and deaths (coefficient 0.84 to 0.90). We conclude that in many practical situations, the pooled test design is a reliable and affordable alternative for the surveillance of SARS-CoV-2 and other viruses.

通过报告的 RT-PCR 阳性检测对 SARS-CoV-2 进行监测,由于检测不是随机的,因此存在偏差。基于人群样本的流行率估计可以纠正这种偏差。在这种情况下,集合检测设计具有许多优势,但在分析此类数据方面仍存在一些挑战。我们开发了一个贝叶斯模型,旨在从重复集中检测数据中估算感染率,同时(i) 校正检测灵敏度;(ii) 传播检测灵敏度的不确定性;(iii) 包括时间和空间上的相关性。我们在模拟场景中对模型进行了验证,结果表明,当样本量至少为 500 个、集合规模低于 20 个、真实感染率低于 5%时,模型是可靠的。我们将该模型应用于 2021-2022 年在瑞士的学校、护理中心和工作场所收集的 149 万个集合测试。我们在这三种环境中发现了类似的动态变化,流行率在 2022 年冬季达到峰值,为 4-5%。我们还发现了不同地区的差异。学校中的流行率估计值与报告病例、住院人数和死亡人数相关(系数为 0.84 至 0.90)。我们的结论是,在许多实际情况下,集合测试设计是监测 SARS-CoV-2 和其他病毒的可靠且经济实惠的替代方法。
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引用次数: 0
A systematic review and meta-analysis of ambient temperature and precipitation with infections from five food-borne bacterial pathogens. 环境温度和降水与五种食源性细菌病原体感染的系统回顾和荟萃分析。
IF 2.5 4区 医学 Q3 INFECTIOUS DISEASES Pub Date : 2024-08-22 DOI: 10.1017/S0950268824000839
Naveen Manchal, Megan K Young, Maria Eugenia Castellanos, Peter Leggat, Oyelola Adegboye

Studies on climate variables and food pathogens are either pathogen- or region-specific, necessitating a consolidated view on the subject. This study aims to systematically review all studies on the association of ambient temperature and precipitation on the incidence of gastroenteritis and bacteraemia from Salmonella, Shigella, Campylobacter, Vibrio, and Listeria species. PubMed, Ovid MEDLINE, Scopus, and Web of Science databases were searched up to 9 March 2023. We screened 3,204 articles for eligibility and included 83 studies in the review and three in the meta-analysis. Except for one study on Campylobacter, all showed a positive association between temperature and Salmonella, Shigella, Vibrio sp., and Campylobacter gastroenteritis. Similarly, most of the included studies showed that precipitation was positively associated with these conditions. These positive associations were found regardless of the effect measure chosen. The pooled incidence rate ratio (IRR) for the three studies that included bacteraemia from Campylobacter and Salmonella sp. was 1.05 (95 per cent confidence interval (95% CI): 1.03, 1.06) for extreme temperature and 1.09 (95% CI: 0.99, 1.19) for extreme precipitation. If current climate trends continue, our findings suggest these pathogens would increase patient morbidity, the need for hospitalization, and prolonged antibiotic courses.

有关气候变量和食品病原体的研究要么针对特定病原体,要么针对特定地区,因此有必要对这一主题进行综合研究。本研究旨在系统回顾有关环境温度和降水量与沙门氏菌、志贺氏菌、弯曲杆菌、弧菌和李斯特菌引起的肠胃炎和菌血症发病率之间关系的所有研究。对 PubMed、Ovid MEDLINE、Scopus 和 Web of Science 数据库的检索截止到 2023 年 3 月 9 日。我们对 3,204 篇文章进行了资格筛选,在综述中纳入了 83 项研究,在荟萃分析中纳入了 3 项研究。除一项关于弯曲杆菌的研究外,其他研究均显示温度与沙门氏菌、志贺氏菌、弧菌和弯曲杆菌肠胃炎之间存在正相关。同样,所纳入的大多数研究都表明,降水与这些病症呈正相关。无论选择哪种效应测量方法,都能发现这些正相关关系。在包括弯曲杆菌和沙门氏菌引起的菌血症的三项研究中,极端气温的汇总发病率比(IRR)为 1.05(95% 置信区间 (95%CI):1.03, 1.06),极端降水的汇总发病率比(IRR)为 1.09(95% CI:0.99, 1.19)。如果目前的气候趋势继续下去,我们的研究结果表明,这些病原体将增加患者的发病率、住院需求和延长抗生素疗程。
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引用次数: 0
High Campylobacter diversity in retail chicken: epidemiologically important strains may be missed with current sampling methods. 零售鸡肉中弯曲杆菌的高度多样性:目前的采样方法可能会遗漏具有流行病学意义的菌株。
IF 2.5 4区 医学 Q3 INFECTIOUS DISEASES Pub Date : 2024-08-22 DOI: 10.1017/S0950268824000906
Agata H Dziegiel, Samuel J Bloomfield, George M Savva, Raphaëlle Palau, Nicol Janecko, John Wain, Alison E Mather

Campylobacter spp. are leading bacterial gastroenteritis pathogens. Infections are largely underreported, and the burden of outbreaks may be underestimated. Current strategies of testing as few as one isolate per sample can affect attribution of cases to epidemiologically important sources with high Campylobacter diversity, such as chicken meat. Multiple culture method combinations were utilized to recover and sequence Campylobacter from 45 retail chicken samples purchased across Norwich, UK, selecting up to 48 isolates per sample. Simulations based on resampling were used to assess the impact of Campylobacter sequence type (ST) diversity on outbreak detection. Campylobacter was recovered from 39 samples (87%), although only one sample was positive through all broth, temperature, and plate combinations. Three species were identified (Campylobacter jejuni, Campylobacter coli, and Campylobacter lari), and 33% of samples contained two species. Positive samples contained 1-8 STs. Simulation revealed that up to 87 isolates per sample would be required to detect 95% of the observed ST diversity, and 26 isolates would be required for the average probability of detecting a random theoretical outbreak ST to reach 95%. An optimized culture approach and selecting multiple isolates per sample are essential for more complete Campylobacter recovery to support outbreak investigation and source attribution.

弯曲杆菌属是主要的细菌性肠胃炎病原体。大部分感染病例都没有得到充分报告,疫情爆发造成的负担可能被低估。目前对每个样本只检测一个分离物的策略会影响将病例归因于鸡肉等弯曲杆菌多样性高的流行病学重要来源。我们采用多种培养方法组合,从英国诺里奇市购买的 45 份零售鸡肉样本中回收弯曲杆菌并对其进行测序,每个样本最多可选取 48 个分离株。在重新采样的基础上进行模拟,以评估弯曲杆菌序列类型(ST)多样性对疫情检测的影响。从 39 个样本(87%)中回收了弯曲杆菌,但只有一个样本在所有肉汤、温度和平板组合中均呈阳性。确定了三个菌种(空肠弯曲杆菌、大肠弯曲杆菌和拉里弯曲杆菌),33%的样本含有两个菌种。阳性样本包含 1-8 个 ST。模拟显示,每个样本需要多达 87 个分离物才能检测到 95% 的观察到的 ST 多样性,而检测到随机理论暴发 ST 的平均概率达到 95% 则需要 26 个分离物。优化培养方法和每个样本选择多个分离物对于更全面地回收弯曲杆菌以支持疫情调查和来源归因至关重要。
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引用次数: 0
Prevalence and persistence of Neisseria meningitidis carriage in Swedish university students - CORRIGENDUM. 瑞典大学生脑膜炎奈瑟氏菌携带率和持久性 - CORRIGENDUM。
IF 2.5 4区 医学 Q3 INFECTIOUS DISEASES Pub Date : 2024-08-22 DOI: 10.1017/S0950268824000840
Olof Säll, Lorraine Eriksson, Idosa Asfaw Berhane, Alexander Persson, Anders Magnuson, Sara Thulin Hedberg, Martin Sundqvist, Per Olcén, Hans Fredlund, Bianca Stenmark, Eva Särndahl, Paula Mölling, Susanne Jacobsson
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引用次数: 0
Risk of central line-associated bloodstream infections during COVID-19 pandemic in intensive care patients in a tertiary care centre in Saudi Arabia. 沙特阿拉伯一家三级医疗中心的重症监护患者在 COVID-19 大流行期间发生中心静脉相关血流感染 (CLABSI) 的风险。
IF 2.5 4区 医学 Q3 INFECTIOUS DISEASES Pub Date : 2024-06-03 DOI: 10.1017/S0950268824000736
Majid M Alshamrani, Aiman El-Saed, Omar Aldayhani, Abdulaziz Alhassan, Abdullah Alhamoudi, Mohammed Alsultan, Mohammed Alrasheed, Fatmah Othman

This retrospective study compared central line-associated bloodstream infection (CLABSI) rates per 1 000 central line days, and overall mortality before and during the COVID-19 pandemic in adult, paediatric, and neonatal ICU patients at King Abdul-Aziz Medical City-Riyadh who had a central line and were diagnosed with CLABSI according to the National Healthcare Safety Network standard definition. The study spanned between January 2018 and December 2019 (pre-pandemic), and January 2020 and December 2021 (pandemic). SARS-CoV-2 was confirmed by positive RT-PCR testing. The study included 156 CLABSI events and 46 406 central line days; 52 and 22 447 (respectively) in pre-pandemic, and 104 and 23 959 (respectively) during the pandemic. CLABSI rates increased by 2.02 per 1 000 central line days during the pandemic period (from 2.32 to 4.34, p < 0.001). Likewise, overall mortality rates increased by 0.86 per 1 000 patient days (from 0.93 to 1.79, p = 0.003). Both CLABSI rates (6.18 vs. 3.7, p = 0.006) and overall mortality (2.72 vs. 1.47, p = 0.014) were higher among COVID-19 patients compared to non-COVID-19 patients. The pandemic was associated with a substantial increase in CLABSI-associated morbidity and mortality.

这项回顾性研究比较了利雅得阿卜杜勒-阿齐兹国王医疗城的成人、儿科和新生儿 ICU 患者在 COVID-19 大流行之前和期间每 1000 个中心管路日的中心管路相关血流感染(CLABSI)率和总死亡率,根据国家医疗安全网的标准定义,这些患者均使用了中心管路并被诊断为 CLABSI。研究时间跨度为 2018 年 1 月至 2019 年 12 月(大流行前)和 2020 年 1 月至 2021 年 12 月(大流行)。SARS-CoV-2通过阳性RT-PCR检测得到确认。研究包括 156 起 CLABSI 事件和 46 406 个中心管路日;大流行前分别为 52 起和 22 447 个,大流行期间分别为 104 起和 23 959 个。大流行期间,每千个中心管路日的 CLABSI 感染率增加了 2.02(从 2.32 增加到 4.34,P = 0.003)。与非 COVID-19 患者相比,COVID-19 患者的 CLABSI 感染率(6.18 vs. 3.7,p = 0.006)和总死亡率(2.72 vs. 1.47,p = 0.014)均较高。大流行导致 CLABSI 相关发病率和死亡率大幅上升。
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引用次数: 0
International travel as a risk factor for gastrointestinal infections in residents of North East England. 国际旅行是英格兰东北部居民胃肠道感染的一个风险因素。
IF 2.5 4区 医学 Q3 INFECTIOUS DISEASES Pub Date : 2024-05-27 DOI: 10.1017/S0950268824000827
Nicola K Love, Claire Jenkins, Noel McCarthy, Kate S Baker, Petra Manley, Deborah Wilson

International travel is thought to be a major risk factor for developing gastrointestinal (GI) illness for UK residents. Here, we present an analysis of routine laboratory and exposure surveillance data from North East (NE) England, describing the destination-specific contribution that international travel makes to the regional burden of GI infection.Laboratory reports of common notifiable enteric infections were linked to exposure data for cases reported between 1 January 2013 and 31 December 2022. Demographic characteristics of cases were described, and rates per 100,000 visits were determined using published estimates of overseas visits from the Office for National Statistics (ONS) International Passenger Survey (IPS).About 34.9% of cases reported international travel during their incubation period between 2013 and 2022, although travel-associated cases were significantly reduced (>80%) during the COVID-19 pandemic. Between 2013 and 2019, half of Shigella spp. and non-typhoidal Salmonella infections and a third of Giardia sp., Cryptosporidium spp., and Shiga toxin-producing Escherichia coli (STEC) infections were reported following travel. Rates of illness were highest in travellers returning from Africa and Asia (107.8 and 61.1 per 100,000 visits), with high rates also associated with tourist resorts like Turkey, Egypt, and the Dominican Republic (386.4-147.9 per 100,000 visits).International travel is a major risk factor for the development of GI infections. High rates of illness were reported following travel to both destinations, which are typically regarded as high-risk and common tourist resorts. This work highlights the need to better understand risks while travelling to support the implementation of guidance and control measures to reduce the burden of illness in returning travellers.

国际旅行被认为是英国居民罹患胃肠道疾病的主要风险因素。在此,我们对英格兰东北部(NE)的常规实验室和暴露监测数据进行了分析,描述了国际旅行对地区消化道感染负担的特定目的地贡献。我们对病例的人口统计学特征进行了描述,并利用国家统计局(ONS)国际旅客调查(IPS)公布的海外访问估计值确定了每 10 万人次的感染率。2013 年至 2022 年期间,约 34.9% 的病例报告在潜伏期内进行过国际旅行,但在 COVID-19 大流行期间,旅行相关病例显著减少(>80%)。2013 年至 2019 年期间,一半的志贺氏杆菌属和非伤寒沙门氏菌感染病例以及三分之一的贾第鞭毛虫属、隐孢子虫属和产志贺毒素大肠杆菌 (STEC) 感染病例都是在旅行后报告的。从非洲和亚洲回国的旅行者发病率最高(分别为每 10 万人次 107.8 例和 61.1 例),土耳其、埃及和多米尼加共和国等旅游胜地的发病率也很高(每 10 万人次 386.4-147.9 例)。国际旅行是导致消化道感染的主要风险因素。据报道,前往这两个通常被视为高风险和常见旅游胜地的目的地旅行后,发病率很高。这项研究表明,有必要更好地了解旅行中的风险,以支持指导和控制措施的实施,减轻回国旅行者的疾病负担。
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引用次数: 0
Analysis and forecasting of syphilis trends in mainland China based on hybrid time series models. 基于混合时间序列模型的中国大陆梅毒趋势分析与预测
IF 2.5 4区 医学 Q3 INFECTIOUS DISEASES Pub Date : 2024-05-27 DOI: 10.1017/S0950268824000694
Zhen D Wang, Chun X Yang, Sheng K Zhang, Yong B Wang, Zhen Xu, Zi J Feng

Syphilis remains a serious public health problem in mainland China that requires attention, modelling to describe and predict its prevalence patterns can help the government to develop more scientific interventions. The seasonal autoregressive integrated moving average (SARIMA) model, long short-term memory network (LSTM) model, hybrid SARIMA-LSTM model, and hybrid SARIMA-nonlinear auto-regressive models with exogenous inputs (SARIMA-NARX) model were used to simulate the time series data of the syphilis incidence from January 2004 to November 2023 respectively. Compared to the SARIMA, LSTM, and SARIMA-LSTM models, the median absolute deviation (MAD) value of the SARIMA-NARX model decreases by 352.69%, 4.98%, and 3.73%, respectively. The mean absolute percentage error (MAPE) value decreases by 73.7%, 23.46%, and 13.06%, respectively. The root mean square error (RMSE) value decreases by 68.02%, 26.68%, and 23.78%, respectively. The mean absolute error (MAE) value decreases by 70.90%, 23.00%, and 21.80%, respectively. The hybrid SARIMA-NARX and SARIMA-LSTM methods predict syphilis cases more accurately than the basic SARIMA and LSTM methods, so that can be used for governments to develop long-term syphilis prevention and control programs. In addition, the predicted cases still maintain a fairly high level of incidence, so there is an urgent need to develop more comprehensive prevention strategies.

梅毒在中国大陆仍然是一个需要关注的严重公共卫生问题,建立模型来描述和预测梅毒的流行模式有助于政府制定更科学的干预措施。本文采用季节自回归综合移动平均(SARIMA)模型、长短期记忆网络(LSTM)模型、混合SARIMA-LSTM模型和带外生输入的混合SARIMA-非线性自回归模型(SARIMA-NARX)分别模拟了2004年1月至2023年11月梅毒发病率的时间序列数据。与 SARIMA、LSTM 和 SARIMA-LSTM 模型相比,SARIMA-NARX 模型的中位绝对偏差(MAD)值分别减少了 352.69%、4.98% 和 3.73%。平均绝对百分比误差 (MAPE) 值分别降低了 73.7%、23.46% 和 13.06%。均方根误差 (RMSE) 值分别降低了 68.02%、26.68% 和 23.78%。平均绝对误差(MAE)值分别降低了 70.90%、23.00% 和 21.80%。与基本的SARIMA和LSTM方法相比,混合SARIMA-NARX和SARIMA-LSTM方法能更准确地预测梅毒病例,因此可用于政府制定长期的梅毒防控计划。此外,预测的病例仍保持相当高的发病率,因此迫切需要制定更全面的预防策略。
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Epidemiology and Infection
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