Environmental Toxicology最新文献_第5页

Polystyrene Nanoparticles Cause Sex-Specific Toxicity in Male Zebrafish, Which Can Be Mitigated by Melatonin. 聚苯乙烯纳米颗粒引起雄性斑马鱼的性别特异性毒性，褪黑激素可以减轻这种毒性。

IF 4.5 3区医学 Q2 ENVIRONMENTAL SCIENCES

Environmental Toxicology

Pub Date : 2026-01-22 DOI: 10.1002/tox.70040

Wanjing Liu,Chunhua Zhan,Min Zeng,Guanglong Chen,Jun Wang

The environmental ubiquity of microplastics raises growing concerns over their reproductive toxicity, although the underlying molecular mechanisms remain unclear. In this study, adult zebrafish were exposed to polystyrene nanoparticles (PSNPs; 0, 0.1, and 1 mg/L) for 14 days, with or without co-treatment of melatonin (1 μM). Exposure to 1 mg/L PSNPs significantly reduced gonadosomatic and brain somatic indices, accompanied by histopathological evidence of structural damage to gonadal tissues. Moreover, PSNPs disrupted hypothalamic-pituitary-gonadal (HPG) axis gene transcription and altered sex hormone levels. PSNPs also induced oxidative stress and apoptosis in gonadal and brain tissues. Notably, these effects were sex-dependent and were largely ameliorated by melatonin co-treatment. Importantly, PSNPs showed differential reproductive toxicity between males and females. These findings highlight the potential of melatonin to mitigate PSNP-induced reproductive toxicity by protecting against oxidative damage and HPG axis disruption while also revealing sex-specific responses to nanoparticle exposure.

微塑料在环境中的普遍存在引起了人们对其生殖毒性的日益关注，尽管其潜在的分子机制尚不清楚。在这项研究中，成年斑马鱼暴露于聚苯乙烯纳米颗粒（psnp; 0、0.1和1 mg/L）中14天，并与褪黑激素（1 μM）共同处理。暴露于1mg /L PSNPs显著降低了性腺和脑体细胞指标，并伴有性腺组织结构损伤的组织病理学证据。此外，PSNPs破坏下丘脑-垂体-性腺（HPG）轴基因转录并改变性激素水平。psnp还可诱导性腺和脑组织的氧化应激和细胞凋亡。值得注意的是，这些影响是性别依赖的，并且通过褪黑激素联合治疗在很大程度上得到改善。重要的是，psnp在雄性和雌性之间表现出不同的生殖毒性。这些发现强调了褪黑素的潜力，通过防止氧化损伤和HPG轴破坏来减轻psnp诱导的生殖毒性，同时也揭示了对纳米颗粒暴露的性别特异性反应。

引用次数: 0

Effects of Glyphosate on the Planktonic Microbiota: An Experimental Approach. 草甘膦对浮游微生物群影响的实验研究。

IF 4.5 3区医学 Q2 ENVIRONMENTAL SCIENCES

Environmental Toxicology

Pub Date : 2026-01-22 DOI: 10.1002/tox.70019

Melissa Progênio,Matheus Henrique Oliveira de Matos,Edilaine Corrêa Leite,Bianca Ramos de Meira,João Vitor Bredariol,José Eduardo Gonçalves,Pablo Augusto Poleto Antiqueira,Luiz Felipe Machado Velho

Glyphosate is one of the most widely used herbicides in the world, including in Brazil, and its dispersion through habitats and surface waters can impact entire aquatic ecosystems. However, experimental studies evaluating the effects of pesticides on whole planktonic communities, considering attributes such as richness, density and composition-remain scarce. This study evaluated the effects of different glyphosate concentrations on freshwater planktonic microbiota, encompassing cyanobacteria, algae, testate amoebae, autotrophic and heterotrophic nanoflagellates, ciliates, rotifers and copepods. We experimentally simulated four contamination scenarios in freshwater microcosms: (i) control (no glyphosate), (ii) low glyphosate (30 μg/L-1), (iii) high glyphosate (500 μg/L-1), (iv) the maximum allowed in Brazil (65 μg/L-1). The effects of glyphosate varied among biological groups, underscoring the complexity of community-level responses to contamination. Some groups, such as autotrophic and heterotrophic nanoflagellates, testate amoebae, rotifers, and copepods, responded only in density, with the total microfaunal community following a similar trend. Shifts in species composition were observed for testate amoebae (species replacement) and cyanobacteria (changes in richness), both of which contributed most to beta diversity variation under pesticide exposure. Microcosms exposed to higher glyphosate concentrations exhibited more distinct community compositions compared to the control, suggesting a shift toward more resistant species. These findings highlight the importance of protecting aquatic environments from pesticide contamination, as both individual species and entire communities exhibit differential sensitivity to chemical stressors, potentially affecting ecosystem functioning and services.

草甘膦是世界上使用最广泛的除草剂之一，包括在巴西，它在栖息地和地表水中的扩散会影响整个水生生态系统。然而，考虑到丰富度、密度和组成等属性，评估农药对整个浮游生物群落影响的实验研究仍然很少。本研究评估了不同草甘膦浓度对淡水浮游微生物群的影响，包括蓝藻、藻类、雄性变形虫、自养和异养纳米鞭毛虫、纤毛虫、轮虫和桡足类。我们在淡水微生物中模拟了四种污染情景：(i)控制（无草甘膦），（ii）低草甘膦（30 μg/L-1），（iii）高草甘膦（500 μg/L-1），（iv）巴西允许的最大污染（65 μg/L-1）。草甘膦的影响在不同的生物群体中有所不同，强调了社区层面对污染反应的复杂性。一些类群，如自养和异养纳米鞭毛虫、雄性变形虫、轮虫和桡足类，仅在密度上有响应，整个微动物群落也遵循类似的趋势。在杀虫剂暴露下，物种组成发生变化的主要是变形虫（物种替代）和蓝藻（丰富度变化），两者对β多样性的变化贡献最大。与对照相比，暴露于较高草甘膦浓度的微生物表现出更明显的群落组成，这表明它们向更具抗性的物种转变。这些发现强调了保护水生环境免受农药污染的重要性，因为个体物种和整个群落对化学压力源的敏感性不同，可能影响生态系统的功能和服务。

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引用次数: 0

Biochemical and Genotoxic Effects of Maneb on Eisenia fetida. 马尾草对臭Eisenia fetida的生化和遗传毒性作用。

IF 4.5 3区医学 Q2 ENVIRONMENTAL SCIENCES

Environmental Toxicology

Pub Date : 2026-01-21 DOI: 10.1002/tox.70042

Salih Dikilitaş,Özlem Aksoy

Maneb is a dithiocarbamate pesticide that is widely used to control many fungal diseases affecting vegetables, fruits, and field crops because of its low acute toxicity and short environmental persistence and is classified as carcinogenic to humans. Eisenia fetida is the preferred model organism for investigating the toxic effects of pesticides and other environmental pollutants. The toxic effects of a maneb fungicide on E. fetida were examined at physiological, biochemical, cellular, and molecular levels. As a result of probit analysis, the lethal concentration (LC50) of maneb on E. fetida was 798.4 mg/kg (dry soil). At sublethal concentrations (50, 100, and 200 mg/kg (dry soil)), decreases were detected in the weight of worms exposed to maneb as the concentration increased. In the analyses performed to detect lipid peroxidation, the amount of MDA increased in parallel with the increase in the maneb concentration and exposure time. CAT and GST enzyme activities were increased at all concentrations compared with the control group during the four sampling days. In the data obtained as a result of comet assay, cell damage increased depending on the changes in the maneb concentration and exposure time. As a result of real-time PCR analysis, increases in the expression of antioxidant enzymes were detected in worms exposed to maneb to clear reactive oxygen species (ROS). This study investigated the effects of maneb on E. fetida for the first time at physiological, biochemical, and molecular levels and contributed to the elucidation of changes in maneb in worms.

马乃布是一种二硫代氨基甲酸酯农药，由于其急性毒性低、环境持久性短，被广泛用于控制影响蔬菜、水果和大田作物的许多真菌疾病，并被列为人类致癌物质。恶臭Eisenia fetida是研究农药和其他环境污染物毒性作用的首选模式生物。从生理、生化、细胞和分子水平研究了一种马麻子杀菌剂对恶臭杆菌的毒性作用。probit分析表明，马麻草对恶臭沼虾的致死浓度（LC50）为798.4 mg/kg（干土）。在亚致死浓度（50、100和200 mg/kg（干土））下，随着浓度的增加，暴露于马麻草的蠕虫体重下降。在检测脂质过氧化的分析中，MDA的量随着麻叶浓度和暴露时间的增加而增加。在4天的采样期间，与对照组相比，所有浓度的CAT和GST酶活性都有所增加。在彗星试验获得的数据中，细胞损伤的增加取决于锰浓度和暴露时间的变化。real-time PCR分析结果显示，暴露于芒果中清除活性氧（ROS）的蠕虫抗氧化酶表达增加。本研究首次从生理、生化和分子水平探讨了马麻草对臭虫的影响，有助于阐明马麻草在蠕虫体内的变化。

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引用次数: 0

Revisiting the Association of Pesticide Exposure and Parkinson's Disease: Systematic Review and Meta-Analysis. 重新审视农药暴露与帕金森病的关系：系统回顾和荟萃分析。

IF 3.2 3区医学 Q2 ENVIRONMENTAL SCIENCES

Environmental Toxicology

Pub Date : 2026-01-21 DOI: 10.1002/tox.70041

Pedro Henrique Passos da Silva, Jadson Silva Abreu, Rafael Sidônio Gibson Gomes, Hemengella Karyne Alves Oliveira, Artur F S Schuh, Ignacio F Mata, Bruno Lopes Santos-Lobato

The association between pesticide exposure and Parkinson's disease (PD) is substantial, but heterogeneity in methodology and lack of categorization according to the type of exposure and pesticide classes in previous meta-analyses impair the interpretation of data. This study aims to update evidence of the association between pesticide exposure and PD. We conducted a systematic review and meta-analysis of studies investigating associations between pesticide exposure and PD according to the type of pesticide exposure and pesticide class. We searched PubMed, EMBASE, and Web of Science until July 2024. Reviewers screened titles and abstracts. Afterward, reviewers reanalyzed the selection criteria and extracted the data based on the full paper. Meta-analyses were conducted to assess the association between pesticide exposure and PD. A total of 124 studies were eligible. There is a lack of diversity in the populations represented and a high variability in methodology among the included studies. Considering only studies with any type of exposure, we found a positive association of PD with any pesticide class and herbicides. Occupational exposure was associated with PD for all pesticide classes except for fungicides. Exclusive household pesticide exposure was also associated with PD. Pesticide exposure remains a significant environmental risk factor for the development of PD, regardless of the type of exposure. Herbicides are the pesticide class with the most substantial evidence of association with the disease. Further studies with new methods of pesticide exposure measurement, innovative design studies, and the inclusion of underrepresented populations are still needed.

农药暴露与帕金森病（PD）之间的关联是实质性的，但方法上的异质性以及缺乏根据暴露类型和农药类别进行分类的meta分析损害了数据的解释。本研究旨在更新农药暴露与PD之间关系的证据。我们根据农药暴露类型和农药类别对农药暴露与PD之间关系的研究进行了系统回顾和荟萃分析。我们检索了PubMed， EMBASE和Web of Science，直到2024年7月。审稿人筛选题目和摘要。随后，审稿人重新分析选择标准，并根据全文提取数据。进行了荟萃分析以评估农药暴露与PD之间的关系。共有124项研究符合条件。所研究的人群缺乏多样性，所纳入研究的方法也存在很大差异。仅考虑任何类型暴露的研究，我们发现PD与任何农药类别和除草剂呈正相关。除杀菌剂外，所有农药类别的职业暴露都与PD相关。单独的家庭农药暴露也与帕金森病有关。农药暴露仍然是PD发生的重要环境风险因素，无论暴露类型如何。除草剂是与该病有关的证据最充分的一类农药。还需要进一步研究新的农药暴露测量方法、创新设计研究和纳入代表性不足的人群。

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引用次数: 0

Comprehensive Evaluation of Bisphenol A Toxicity Reveals Neurobehavioral, Metabolic, and Reproductive Impairments in Girardia tigrina. 双酚A毒性的综合评价揭示了红Girardia的神经行为、代谢和生殖损伤。

IF 4.5 3区医学 Q2 ENVIRONMENTAL SCIENCES

Environmental Toxicology

Pub Date : 2026-01-19 DOI: 10.1002/tox.70039

Raquel de Jesus Selestrino,Felipe Schaly,Welligton Luciano Braguini

Bisphenol A (BPA), a common industrial chemical used in plastics and consumer products, is increasingly detected in aquatic environments, raising serious concerns about its potential ecological impacts. This study evaluated the sublethal and acute toxic effects of BPA on the freshwater planarian Girardia tigrina, a recognized model for neurotoxicity and regenerative biology. Acute exposure revealed a time-dependent decrease in LC50 values, from 53.18 μM at 24 h to 22.38 μM at 96 h. Behavioral assays showed significant locomotor impairment, with activity reduced by 36.7% and 57.2% at 1.0 and 5.0 μM, respectively. The LC50 for movement inhibition was estimated at 2.79 μM after only 5 min of exposure. Stereotyped movements intensified with concentration and duration. Reproduction was markedly affected, with fecundity and fertility reduced by 96.7% and 100% at 2.5 μM; no hatchlings emerged at 1.0 or 2.5 μM. Glycogen reserves dropped by 42.9% at 2.5 μM, indicating metabolic disruption. Marked oxidative stress responses were observed, with superoxide dismutase and catalase activities increasing by over 220%. Glutathione S-transferase activity was elevated across all concentrations. Acetylcholinesterase activity showed a biphasic response-strong inhibition at lower doses (-67.8% at 0.1 μM), followed by stimulation at 1.0 μM (+56.9%)-suggesting cholinergic disruption. Collectively, these results demonstrate that BPA disrupts multiple physiological systems in planarians at environmentally relevant levels, underscoring the need for more comprehensive environmental monitoring and the adoption of safer chemical alternatives to protect aquatic biodiversity.

双酚A （BPA）是一种用于塑料和消费品的常见工业化学品，在水生环境中被越来越多地检测到，引起了人们对其潜在生态影响的严重关注。本研究评估了双酚a对淡水涡虫（一种公认的神经毒性和再生生物学模型）的亚致死和急性毒性作用。急性暴露显示LC50值随时间变化，从24 h时的53.18 μM下降到96 h时的22.38 μM。行为学分析显示，1.0 μM和5.0 μM时，小鼠的运动能力分别下降了36.7%和57.2%。暴露5 min后，LC50为2.79 μM。刻板的动作随着注意力和持续时间的增加而加强。繁殖受到明显影响，2.5 μM下繁殖力和育性分别下降96.7%和100%；1.0 μM和2.5 μM无孵化。糖原储备在2.5 μM时下降42.9%，表明代谢中断。氧化应激反应明显，超氧化物歧化酶和过氧化氢酶活性增加220%以上。所有浓度的谷胱甘肽s -转移酶活性均升高。乙酰胆碱酯酶活性表现出双相反应——低剂量（0.1 μM -67.8%）强抑制，1.0 μM刺激（+56.9%），提示胆碱能破坏。总的来说，这些结果表明BPA在环境相关水平上破坏了涡虫的多种生理系统，强调需要更全面的环境监测和采用更安全的化学替代品来保护水生生物多样性。

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引用次数: 0

Organic and Inorganic Pollutants, Oxidative Stress Biomarkers, and Electrophoretic Protein Profiles in an Endangered Thresher Shark (Alopias vulpinus) From Southeastern Brazil: A Case Study. 巴西东南部濒危长尾鲨（Alopias vulpinus）的有机和无机污染物、氧化应激生物标志物和电泳蛋白谱：一个案例研究。

IF 4.5 3区医学 Q2 ENVIRONMENTAL SCIENCES

Environmental Toxicology

Pub Date : 2026-01-15 DOI: 10.1002/tox.70026

Sidney Fernandes Sales Junior,Amanda Pontes Lopes,Heloíse Martins de Souza,Regina Fonseca,Enrico Mendes Saggioro,Francielli Monteiro Casanova,Kamila Cezar Gramlich,Tatiana Dillenburg Saint'Pierre,Carlos German Massone,Renato Carreira,Rachel Ann Hauser-Davis

A comprehensive screening of different environmental contaminants (total metals, thermostable metal fractions associated with detoxification, and persistent organic pollutants) was conducted in an endangered common thresher shark (Alopias vulpinus ) individual incidentally captured in southeastern Brazil. Stress biomarkers were assessed to evaluate physiological responses, and SDS-PAGE was applied to identify thermostable protein profiles. Most metals were more abundant in total than in thermostable fractions, suggesting partial cellular absorption, likely through compartmentalization in organelles or binding to metallothioneins. Of 25 screened pesticides, only p,p'-DDT and Mirex were detected, with unexpectedly high levels observed in liver. Several low molecular weight PAHs were also found in both tissues, especially muscle, suggesting chronic exposure and bioaccumulation. The SDS-PAGE revealed ~15 kDa bands, consistent with metallothioneins, and higher bands possibly corresponding to matrix metalloproteinases. Poor resolution in the Ampullae of Lorenzini was likely due to high salt content. Antioxidant biomarkers showed tissue-specific patterns, with high H2O2 levels and SOD activity in gills, blood, and brain, suggesting oxidative stress. Further studies are, however, required, as a sample number of one precludes broad conclusions at the species level. Despite this limitation, the study provides valuable preliminary insights and a baseline for Alopias spp. The integrated biochemical and molecular approach applied herein may aid in detecting early physiological stress and sublethal contamination effects and, combined with ecological and life-history data, can inform conservation strategies, such as habitat prioritization, pollutant mitigation, and monitoring programs, to support the long-term survival and population viability of this and other vulnerable shark species.

对巴西东南部偶然捕获的一条濒危普通长尾鲨（Alopias vulpinus）进行了不同环境污染物（总金属、与解毒相关的耐热金属组分和持久性有机污染物）的综合筛选。评估应激生物标志物以评估生理反应，并应用SDS-PAGE鉴定热稳定性蛋白谱。大多数金属在总量上比在耐热组分中更丰富，表明部分细胞吸收，可能是通过细胞器的区隔化或与金属硫蛋白结合。在筛选的25种农药中，只检测到p、p'-DDT和灭螨，在肝脏中发现的含量出乎意料地高。在两种组织中也发现了一些低分子量的多环芳烃，特别是肌肉，表明慢性暴露和生物积累。SDS-PAGE显示约15 kDa的条带与金属硫蛋白一致，较高的条带可能与基质金属蛋白酶相对应。洛伦兹尼壶腹的分辨率低可能是由于含盐量高。抗氧化生物标志物显示出组织特异性模式，鳃、血液和大脑中H2O2水平和SOD活性高，表明氧化应激。然而，还需要进一步的研究，因为一个样本的数量排除了在物种水平上的广泛结论。尽管存在这些局限性，但该研究为Alopias spp提供了有价值的初步见解和基线。本文应用的综合生化和分子方法可能有助于检测早期生理应激和亚致死污染效应，并结合生态和生活史数据，可以为保护策略提供信息，例如栖息地优先排序，污染物缓解和监测计划。支持这种和其他易受伤害的鲨鱼物种的长期生存和种群活力。

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引用次数: 0

Impact of Conventional vs. Biodegradable and Compostable Microplastics on Eisenia fetida S.: An Ecopathological Approach. 传统微塑料与可生物降解和可堆肥微塑料对臭虫的影响：一种生态病理学方法。

IF 4.5 3区医学 Q2 ENVIRONMENTAL SCIENCES

Environmental Toxicology

Pub Date : 2026-01-12 DOI: 10.1002/tox.70030

Karen Power,Lorenzo Riccio,Antonietta Siciliano,Lucia Santorufo,Luigi Rosati,Simone Landi,Salvatore Avilia,Rebecca Leandri,Carmine Vitagliano,Giorgia Santini,Gionata De Vico,Giulia Maisto

Microplastics represent an emerging issue endangering all ecosystems including soils, where the impact of both conventional and biobased ones remains controversial. The study aimed to assess the effects of two concentrations (1% and 2%) of biodegradable and compostable microplastics and conventional high-density polyethylene microplastics on the abiotic properties of soil, and the ecotoxicological and ecopathological impacts on Eisenia fetida (Savigny, 1826) through histological techniques. Analyses conducted on the evaluation of abiotic soil parameters after 28 days of exposure did not show any significant change compared to the control samples. Ecotoxicological results showed increased mortality and decreased biomass across all treated groups after 14 days of exposure, while a significant reduction in offspring was only observed in 1%-biodegradable and compostable microplastics. Ecopathological analysis revealed inflammatory and/or degenerative phenomena in the epidermal and muscular layers in all treated groups after 14 days of exposure, suggesting the presence of sublethal effects which could impair the well-being of individuals. Overall, our results suggest that the ecopathological approach combined with the classical ecotoxicological one can help explain pathological events which are behind the ecotoxicological endpoints and underline the existence of fine tissue and cell damage even when no changes are observed during ecotoxicological studies.

微塑料是一个危及包括土壤在内的所有生态系统的新问题，传统和生物基塑料的影响仍然存在争议。本研究旨在通过组织学技术评估两种浓度（1%和2%）的可生物降解和可堆肥微塑料和常规高密度聚乙烯微塑料对土壤非生物特性的影响，以及对臭Eisenia fetida （Savigny, 1826）的生态毒理学和生态病理学影响。与对照样品相比，暴露28天后对非生物土壤参数的评估分析没有显示出任何显著变化。生态毒理学结果显示，接触14天后，所有处理组的死亡率增加，生物量减少，而仅在1%可生物降解和可堆肥的微塑料中观察到后代的显著减少。生态病理学分析显示，暴露14天后，所有处理组的表皮和肌肉层都出现了炎症和/或退行性现象，这表明存在亚致死效应，可能损害个体的健康。总的来说，我们的研究结果表明，生态病理学方法与经典的生态毒理学方法相结合，可以帮助解释生态毒理学终点背后的病理事件，并强调即使在生态毒理学研究中没有观察到任何变化，精细组织和细胞损伤的存在。

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引用次数: 0

Keeping Pace With Global Environmental Challenges in the Next Chapter for Environmental Toxicology 在环境毒理学的下一章跟上全球环境挑战的步伐

IF 4.5 3区医学 Q2 ENVIRONMENTAL SCIENCES

Environmental Toxicology

Pub Date : 2026-01-10 DOI: 10.1002/tox.70025

April Rodd

引用次数: 0

Cyanopeptide Mixtures Induce Variable Synergistic and Antagonistic Effects Across Diverse Human Cell Lines 氰肽混合物在不同的人类细胞系中诱导不同的协同和拮抗作用

IF 4.5 3区医学 Q2 ENVIRONMENTAL SCIENCES

Environmental Toxicology

Pub Date : 2026-01-10 DOI: 10.1002/tox.70028

Lauren N. Hart, Katherine L. Lev, Sierra Hefferan, Sanduni H. Premathilaka, Sharmila I. Thenuwara, Dragan Isailovic, David H. Sherman, Gregory J. Dick

Cyanobacterial harmful algal blooms (cyanoHABs) threaten human, animal, and ecosystem health and safety through production of toxic secondary metabolites. Microcystis, a cosmopolitan bloom‐forming cyanobacterial genus, is well‐known for producing hepatotoxic microcystins (MCs), but it can produce many other bioactive cyanopeptides, such as anabaenopeptins (APs), that occur at high levels in blooms. The toxicological and ecological impacts of such co‐occurring cyanopeptides in the natural environment remain understudied. Here we evaluated the effects of pure MCs and APs individually and in combination, as well as extracts of Microcystis cultures producing diverse suites of cyanopeptides, including strains with and without MCs and APs, on human lung (A549), kidney (HK2), and liver (Hep‐3B) cell viability. Individual MC and AP congeners exhibited a gradient of toxic effects across cell lines; MC‐LA caused the most toxic effects, MC‐LR had comparable effects to AP‐A and AP‐B, and MC‐RR caused the least toxicity. Combined exposure to MC‐LA and AP‐B produced dose‐dependent synergistic effects across all three cell lines. Microcystis culture extracts significantly reduced cell viability in dose‐ and Microcystis strain‐dependent patterns that could not be explained by microcystin or anabaenopeptin content alone, suggesting a role of other metabolites and their interactions within the mixtures. These findings demonstrate that mixtures of environmentally relevant cyanopeptides can have greater toxic threats than individual compounds and underscore the importance of considering metabolites beyond MCs and their potential interactions in public health, future risk assessments, and management strategies for cyanoHAB‐impacted waters.

蓝藻有害藻华（cyanoHABs）通过产生有毒的次生代谢物威胁着人类、动物和生态系统的健康和安全。微囊藻是一种世界性的形成藻华的蓝藻属，以产生肝毒性微囊藻毒素（MCs）而闻名，但它可以产生许多其他生物活性的藻肽，如在藻华中大量出现的生长素（APs）。这些共同发生的氰肽在自然环境中的毒理学和生态影响仍未得到充分研究。在这里，我们评估了纯MCs和APs单独和组合的影响，以及产生多种氰肽的微囊藻培养物的提取物，包括含和不含MCs和APs的菌株，对人肺（A549）、肾（HK2）和肝（Hep‐3B）细胞活力的影响。单个MC和AP同系物在细胞系间表现出梯度的毒性作用；MC‐LA引起的毒性作用最大，MC‐LR与AP‐A和AP‐B的毒性作用相当，MC‐RR引起的毒性最小。MC - LA和AP - B联合暴露在所有三种细胞系中产生剂量依赖的协同效应。微囊藻培养提取物在剂量依赖性和菌株依赖性模式下显著降低了细胞活力，这不能单独用微囊藻毒素或anabaenopeptin含量来解释，这表明混合物中其他代谢物及其相互作用的作用。这些发现表明，与环境相关的氰肽混合物可能比单个化合物具有更大的毒性威胁，并强调了考虑MCs以外的代谢物及其在公共卫生、未来风险评估和氰藻有害藻华影响水域管理策略中的潜在相互作用的重要性。

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引用次数: 0

RETRACTION: Diallyl Disulfide Downregulating RhoGDI2 Induces Differentiation and Inhibit Invasion Via the Rac1/Pak1/LIMK1 Pathway in Human Leukemia HL-60 Cells 撤回：二烯丙基二硫下调RhoGDI2在人白血病HL-60细胞中通过Rac1/Pak1/LIMK1途径诱导分化并抑制侵袭

IF 3.2 3区医学 Q2 ENVIRONMENTAL SCIENCES

Environmental Toxicology

Pub Date : 2026-01-09 DOI: 10.1002/tox.70038

RETRACTION: T. Hui, J. Yiling, C. Guangqun, L. Ran, L. Hui, Y. Lan, H. Jie, and Q. Su, “ Diallyl Disulfide Downregulating RhoGDI2 Induces Differentiation and Inhibit Invasion Via the Rac1/Pak1/LIMK1 Pathway in Human Leukemia HL-60 Cells,” Environmental Toxicology 38, no. 5 (2023): 1063–1077, https://doi.org/10.1002/tox.23748.

The above article, published online on 15 February 2023, in Wiley Online Library (http://onlinelibrary.wiley.com/), has been retracted by agreement between the journal Editor-in-Chief, April Rodd; and Wiley Periodicals LLC. Following publication, duplicate portions of images were found within Figures 2A, 2F, 3C, and 3F. The publisher contacted the authors about the duplicated images, and they provided raw data along with an explanation. After further review, the editor concluded that the raw data and explanation were not sufficient to address the concerns raised. This retraction has been agreed to because the problems with the figures made the editor lose confidence in the data and results presented. The authors stated that the errors were unintentional, arising from figure preparation, and did not reflect any intention to misrepresent the underlying research or its conclusions.

引用本文：许涛，许一玲，陈广群，冉莉，许莉，兰玉杰，苏强，“二烯丙基二硫下调RhoGDI2在人白血病HL-60细胞中诱导分化和抑制Rac1/Pak1/LIMK1通路的作用”，环境毒理学杂志，38,no. 1。5 (2023): 1063-1077, https://doi.org/10.1002/tox.23748。上述文章于2023年2月15日在线发表在Wiley在线图书馆（http://onlinelibrary.wiley.com/）上，经期刊主编April Rodd；出版后，在图2A、2F、3C和3F中发现了图像的重复部分。出版商就复制图片的事联系了作者，他们提供了原始数据并给出了解释。经过进一步审查，编辑得出结论，原始数据和解释不足以解决所提出的问题。这次撤稿已经得到同意，因为数据上的问题使编辑对所呈现的数据和结果失去了信心。作者表示，这些错误是无意的，是由数字准备引起的，并没有反映出任何歪曲基础研究或其结论的意图。

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引用次数: 0