Environmental Toxicology最新文献_第5页

Prenatal Ethion Exposure Disrupts Reproductive Health in First-Generation Rats. 产前接触乙硫磷会破坏第一代大鼠的生殖健康。

IF 4.5 3区医学 Q2 ENVIRONMENTAL SCIENCES

Environmental Toxicology

Pub Date : 2025-11-29 DOI: 10.1002/tox.70008

Elizabeth Glanet Durom,V A Aneesha,Nerella Venkata Pavan Kumar,M Karikalan,Meemansha Sharma,Madhu C Lingaraju,Subhashree Parida,Manjit Panigrahi,Avinash G Telang,Thakur Uttam Singh

Ethion is a commonly used OP (Organophosphate) pesticide. The present study evaluated the transgenerational reproductive effects of prenatal ethion exposure in rats. Different doses of ethion were orally administered to pregnant rats from gestational day (GD) 6-19, at doses of 0.86, 1.7, 3.43, and 6.9 mg/kg in groundnut oil. On post-natal day (PND) 1, body weight, crown-rump length (CRL), anogenital distance (AGD), tail length, and physical status of pups were evaluated. Post-natal survival was assessed by weekly monitoring of body weight, day of pinna detachment, teeth eruption, fur development, and eye and ear opening. Pubertal onset and oestrus cycle duration were recorded in female and male offspring and they were sacrificed on PND 60, and 75 respectively. Sperm parameters and levels of malondialdehyde (MDA), reduced glutathione (GSH), and superoxide dismutase (SOD), catalase, mRNA expression of 3β-Hydroxysteroid dehydrogenase (3βHSD), DNA fragmentation, and histology of reproductive organs were evaluated. Lower ethion doses increased body weights, CRL, AGD, and tail lengths in pups. However, the highest dose showed significant weight reduction. Ethion delayed all postnatal developmental milestones in Filial (F1) offspring. In females, ethion-exposed groups showed prolonged oestrus cycle duration. MDA levels were elevated in the uterus, ovary, and testis. The uterus of ethion groups showed marked papillary projections and severe myometrial degeneration. The ovary showed disrupted ovarian stroma architecture and fewer developing and matured follicles in the ethion groups. mRNA expression of the 3βHSD gene revealed decreased fold change except in the 1.7 mg/kg group where an increase in the fold change was recorded. Ethion advanced the testis descent and delayed pubertal onset in males. It also reduced sperm count, motility, intact acrosome percentage, and increased sperm abnormalities. Ethion caused severe testicular degeneration with necrosis of spermatogonial cells and the formation of giant cells. It caused a decrease in the fold change of mRNA expression of the 3βHSD gene in the ovary and testis. No DNA fragmentation was observed. The findings indicate that prenatal ethion exposure induced marked transgenerational reproductive toxicity in rats.

乙硫磷是一种常用的有机磷农药。本研究评估了大鼠产前接触硫醚的跨代生殖效应。从妊娠第6 ~ 19天开始，以花生油中0.86、1.7、3.43、6.9 mg/kg的剂量给药妊娠大鼠。在出生后第1天（PND），评估幼犬的体重、冠臀长（CRL）、肛门生殖器距离（AGD）、尾巴长度和身体状况。通过每周监测体重、耳廓脱落天数、牙齿萌出、毛发发育、眼睛和耳朵张开来评估产后生存。记录雌性和雄性后代的发情期和发情周期，分别于PND 60和75处死。检测精子参数及丙二醛（MDA）、还原型谷胱甘肽（GSH）、超氧化物歧化酶（SOD）、过氧化氢酶水平、3β-羟基类固醇脱氢酶（3βHSD） mRNA表达、DNA片段化和生殖器官组织学。较低的硫醚剂量增加了幼崽的体重、CRL、AGD和尾巴长度。然而，最高剂量显示体重明显减轻。Ethion延迟了孝子（F1）后代的所有出生后发育里程碑。在雌性中，暴露组的发情期持续时间延长。子宫、卵巢和睾丸的丙二醛水平升高。实验组子宫乳头状突起明显，子宫肌层严重变性。卵巢间质结构被破坏，卵泡发育和成熟较少。3βHSD基因mRNA表达呈下降趋势，但1.7 mg/kg组有升高趋势。Ethion使男性睾丸下降提前，青春期发育延迟。它还会减少精子数量、活力、完整顶体百分比，并增加精子异常。乙硫磷引起严重的睾丸变性，伴精原细胞坏死和巨细胞形成。引起卵巢和睾丸3βHSD基因mRNA表达量的倍增变化。未观察到DNA断裂。研究结果表明，产前接触硫醚可引起大鼠明显的跨代生殖毒性。

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引用次数: 0

Toxicity of Four Common Environmental Chemicals Across Caenorhabditis elegans Life Stages Supporting the One Health Concept 四种常见环境化学物质在秀丽隐杆线虫生命阶段的毒性支持同一个健康概念

IF 4.5 3区医学 Q2 ENVIRONMENTAL SCIENCES

Environmental Toxicology

Pub Date : 2025-11-28 DOI: 10.1002/tox.70002

Fábio Campos, Maria D. Pavlaki, Amadeu M. V. M. Soares, Susana Loureiro

Pesticides and pharmaceuticals are among the most common chemical groups in waterbodies and soils, and their universal distribution raises concerns about potential adverse effects on nontarget organisms and humans. Reproductive output disruption is of particular concern, as it transposes effects from the individual to the next generations at the population level, requiring precise identification of the affected processes. Caenorhabditis elegans , with its well‐known lifecycle, is an excellent model organism for investigating such effects within the One Health framework. The present study evaluated the toxicity of four globally prevalent chemicals: the insecticides cypermethrin and flupyradifurone, the herbicide MCPA, and the pharmaceutical diclofenac, at different C. elegans life stages to determine possible effects on different reproductive processes. Embryotoxicity was evaluated by the hatching rates of exposed eggs. Developmental toxicity was assessed by exposing L1 larvae for 96 h and measuring total offspring production and feeding rate. Intergenerational effects were evaluated by hatching rates of in utero exposed eggs (removed from exposed adults). Our results indicate that all substances affected C. elegans in one or more different life stages. Cypermethrin and MCPA showed the highest developmental toxicity, while the latter was also the most toxic for embryo development and intergenerational effects. This targeted approach highlights unexpected reproductive impacts unrelated to the chemicals' primary modes of action. Our findings emphasize the potential of C. elegans in developing adverse outcome pathways, contributing to more realistic hazard predictions regarding human health and animal well‐being and protecting the environment within the One Health approach.

农药和药品是水体和土壤中最常见的化学类群，它们的普遍分布引起了人们对非目标生物和人类潜在不利影响的担忧。生殖产出中断尤其令人关切，因为它在种群水平上将影响从个人转移到下一代，需要精确确定受影响的过程。秀丽隐杆线虫具有众所周知的生命周期，是在同一个健康框架内研究此类影响的极好模式生物。本研究评估了四种全球普遍使用的化学品：杀虫剂氯氰菊酯和氟吡喃酮、除草剂MCPA和药物双氯芬酸在秀丽隐杆线虫不同生命阶段的毒性，以确定对不同生殖过程可能产生的影响。通过暴露卵的孵化率评价胚胎毒性。通过L1幼虫暴露96 h，测定总子代产量和摄食率来评估发育毒性。通过子宫内暴露的卵（从暴露的成年卵中取出）的孵化率来评估代际效应。我们的结果表明，所有的物质影响秀丽隐杆线虫在一个或多个不同的生命阶段。氯氰菊酯和MCPA表现出最高的发育毒性，而后者对胚胎发育的毒性和代际效应也最大。这种有针对性的方法突出了与化学物质的主要作用方式无关的意想不到的生殖影响。我们的研究结果强调秀丽隐杆线虫在发展不良后果途径方面的潜力，有助于对人类健康和动物福祉进行更现实的危害预测，并在同一个健康方法中保护环境。

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引用次数: 0

Correction to “Unveiling the Anticarcinogenic Potential of Inula racemosa Hook. f. Root Extract Against DMBA-Induced Mammary Tumour in Sprague Dawley Rats” 更正“揭示总状菊的抗癌潜力”。f.根提取物对DMBA诱导大鼠乳腺肿瘤的抑制作用

IF 3.2 3区医学 Q2 ENVIRONMENTAL SCIENCES

Environmental Toxicology

Pub Date : 2025-11-28 DOI: 10.1002/tox.70009

A. Jaikaria, R. Kumar, R. K. Asrani, S. Jamwal, A. Verma, J. G. Santoshrao, H. K. Bisen, V. Patial, D. Sharma, R. Kumar, A. Kumar, and R. D. Patil, “Unveiling the Anticarcinogenic Potential of Inula racemosa Hook. f. Root Extract Against DMBA-Induced Mammary Tumour in Sprague Dawley Rats,” Environmental Toxicology 40, no. 1 (2025): 111–127, https://doi.org/10.1002/tox.24419.

We apologize for this error.

A. Jaikaria， R. Kumar， R. K. Asrani， S. Jamwal， A. Verma， J. G. Santoshrao， H. K. Bisen， V. Patial， D. Sharma， R. Kumar， A. Kumar， R. D. Patil，“揭示总状叶Inula racemosa Hook的抗癌潜力”。f.根提取物对dmba诱导的Sprague Dawley大鼠乳腺肿瘤的抑制作用，《环境毒理学》，第40期。1 (2025): 111-127, https://doi.org/10.1002/tox.24419.We为这个错误道歉。

引用次数: 0

Impact of Pesticide Exposure on the Metabolic and Tissue Health of Scincus scincus (Reptilia: Scincidae) in Southeastern Algeria 农药暴露对阿尔及利亚东南部Scincus（爬行动物：Scincus）代谢和组织健康的影响

IF 4.5 3区医学 Q2 ENVIRONMENTAL SCIENCES

Environmental Toxicology

Pub Date : 2025-11-27 DOI: 10.1002/tox.70004

Aicha Mouane, Maria Chikha, Fares Mohamed Amine, Khadra Afaf Bendrihem, Asma Abid, Soundes Akriche, Adel A. Ibrahim, Ayomide Victor Atoki, Fahima Neffar, Salima Zereg, Smail Djerou, Abderrahmane Ararem, Mohammed Messaoudi

This study aims to investigate the biochemical and histological impacts of pesticide exposure on the sandfish skink, Scincus scincus , in the agricultural region of El Oued‐Souf, Algeria. We carried out biochemical blood analysis and histological examination on lizards sampled from sites with high, moderate, and low exposure to pesticides. Biochemical analyses revealed significant disturbances in glucose and lipid metabolism, renal function, and systemic inflammation, correlating with varying levels of exposure to pesticides. The high‐exposure group exhibited marked hyperglycemia (2.06 ± 0.29 mmol/L), elevated cholesterol (1.99 ± 0.44 mmol/L), and triglycerides (1.28 ± 0.42 mmol/L), along with significant increases in C‐reactive protein levels (11.78 ± 9.4), indicating systemic inflammation. Histological examination of heart, liver, and stomach tissues revealed a clear, exposure‐gradient‐dependent spectrum of pathological alterations. In samples from high‐exposure sites, tissues exhibited prominent interstitial fibrosis, marked infiltration of inflammatory cells, and a pronounced disruption of normal cellular architecture. These findings provide compelling evidence that increasing levels of pesticide exposure in agricultural areas are linked not only to systemic biochemical disturbances but also to significant local tissue damage in Scincus scincus , thus underlining the broader ecological and public health risks associated with intensive pesticide use.

本研究旨在研究农药暴露对阿尔及利亚El Oued‐Souf农业区沙鱼皮肤的生化和组织学影响。我们对在农药高、中、低暴露点取样的蜥蜴进行了血液生化分析和组织学检查。生化分析显示葡萄糖和脂质代谢、肾功能和全身炎症的显著紊乱与不同水平的农药暴露有关。高暴露组表现出明显的高血糖（2.06±0.29 mmol/L），胆固醇（1.99±0.44 mmol/L）和甘油三酯（1.28±0.42 mmol/L）升高，同时C反应蛋白水平显著升高（11.78±9.4），表明全身性炎症。心脏、肝脏和胃组织的组织学检查显示出清晰的、暴露梯度依赖性的病理改变谱。在高暴露部位的样本中，组织表现出明显的间质纤维化，明显的炎症细胞浸润，以及正常细胞结构的明显破坏。这些发现提供了令人信服的证据，表明农业地区农药暴露水平的增加不仅与系统性生化紊乱有关，而且还与香草树的严重局部组织损伤有关，从而强调了与大量使用农药有关的更广泛的生态和公共卫生风险。

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引用次数: 0

A Bioluminescent Bacterial Toxicity Assay for Tropical Marine Environments 热带海洋环境的生物发光细菌毒性测定

IF 4.5 3区医学 Q2 ENVIRONMENTAL SCIENCES

Environmental Toxicology

Pub Date : 2025-11-25 DOI: 10.1002/tox.70003

Heidi M. Luter, Katarina Damjanovic, Marie C. Thomas, Rebecca Fisher, Lone Hoj, Andrew P. Negri

Bioassays using bioluminescent bacteria offer a cost‐effective and efficient alternative to standard toxicity assays for assessing contaminant risks in the environment, with applications in water quality assessments and effluent screening spanning decades. However, most bacterial bioassays utilize Aliivibrio fischeri in a low‐throughput format under temperate conditions, limiting their suitability for tropical marine environments. Furthermore, conventional A. fischeri assays rely on short exposure periods (e.g., 5, 15, 30 min) and luminescence as the sole toxicity endpoint, reducing their applicability for deriving water quality guideline values. This study aimed to develop a high‐throughput, and cost‐effective assay using the tropical bioluminescent bacterium Vibrio azureus (Lum‐31), incorporating toxicity endpoints suitable for both acute and chronic contaminant assessment in tropical marine conditions. Using copper and zinc as reference toxicants, we demonstrated the repeatability of the acute luminescence assay at 15 and 30 min, with increased sensitivity compared to A. fischeri assays. In addition, integrating an ecologically relevant endpoint (specific growth rate) and a chronic exposure period (> 24 h) enabled comparisons of V. azureus sensitivity with other taxa in sensitivity distributions for copper and zinc species. This approach enhances the ecological relevance of the assay and improves its applicability for future ecological risk assessments in tropical marine environments.

使用生物发光细菌的生物分析为评估环境中污染物风险的标准毒性分析提供了一种具有成本效益和效率的替代方案，在水质评估和废水筛选方面的应用跨越了几十年。然而，大多数细菌生物测定在温带条件下以低通量形式利用费氏阿里弧菌，限制了它们对热带海洋环境的适用性。此外，传统的费氏弧菌测定依赖于短暴露时间（例如，5、15、30分钟）和发光作为唯一的毒性终点，这降低了它们在获得水质指导值方面的适用性。本研究旨在利用热带生物发光细菌蓝色弧菌（Lum - 31）开发一种高通量、高成本效益的检测方法，并结合适合热带海洋条件下急性和慢性污染物评估的毒性终点。使用铜和锌作为参考毒物，我们证明了在15和30分钟的急性发光试验的重复性，与费氏假单胞菌试验相比，灵敏度更高。此外，结合生态相关终点（特定生长率）和慢性暴露期（24 h），比较了紫花苜蓿与其他类群对铜和锌的敏感性分布。这种方法增强了分析的生态相关性，并提高了其在热带海洋环境中未来生态风险评估的适用性。

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引用次数: 0

Iowa Population Exposures to Metals and Metalloids in Well Water 爱荷华州人口对井水中金属和类金属的暴露

IF 4.5 3区医学 Q2 ENVIRONMENTAL SCIENCES

Environmental Toxicology

Pub Date : 2025-11-24 DOI: 10.1002/tox.70005

Donald L. Simmons, Brian Wels, Alyssa Mattson, Elizabeth M. Miller, Zachary E. Hoggarth, Maya Sternberg, Susie Y. Dai, Dustin May, Michael Schueller, Michael Pentella

Previous Iowa studies suggest low levels and chronic arsenic exposures are associated with prostate cancer. The rural Iowa population heavily relies on private wells for drinking water resources and thus is vulnerable to contaminants such as heavy metals found in well water. The Iowa Biomonitoring Program focuses on determining the extent of chemical exposure through urine biomarker testing in the rural Iowa population which uses private well water as their primary drinking water source. Besides the previously identified high risk of arsenic, the current exposure study expands to a panel of 16 elements such as lead, arsenic, cadmium, barium, strontium and uranium. The State Hygienic Laboratory at the University of Iowa (SHL) enrolled 1189 participants for the private well study for surveillance of arsenic and other elements of interest as part of a larger surveillance effort. Water samples and urine specimens were collected by 1018 participants and sent to the State Hygienic Laboratory for analysis. Analytical methods used for the determination of elements in water and urine were validated prior to use and were based on established methods from the Centers for Disease Control and Prevention (CDC). Water samples and urine specimens were analyzed for lead, cadmium, uranium, arsenic, tin, strontium, cobalt, thallium, manganese, barium, beryllium, molybdenum, tungsten, cesium, platinum, and antimony. The initial analysis of the data indicates statistically significant positive correlations between well water and urinary concentrations of arsenic, uranium and strontium (Spearman's rank‐order correlation coefficients of 0.230, 0.466, and 0.314, respectively). Cadmium, lead, and other metals tested showed no significant correlation with well water. For the first time in Iowa, we identified a moderate association of urine uranium to uranium found in well water. This suggests that exposure to uranium is occurring by drinking well water. In addition, the correlation of arsenic in well water and urine showed a weak positive association as evidence of exposure to arsenic from drinking well water. Strontium was also correlated in urine and well water. Participants whose well water had arsenic levels at or above the maximum contaminant level (MCL) were contacted to increase awareness of the risk of arsenic exposure. Most of the participants indicated they had water treatment systems in use which may explain the weak correlation and give supporting evidence of public health outreach in the area.

爱荷华州以前的研究表明，低水平和长期接触砷与前列腺癌有关。爱荷华州农村人口严重依赖私人水井获取饮用水资源，因此很容易受到井水中重金属等污染物的污染。爱荷华州生物监测项目的重点是通过尿液生物标志物测试确定以私人井水作为主要饮用水源的爱荷华州农村人口的化学物质暴露程度。除了先前确定的砷的高风险外，目前的暴露研究扩大到16种元素，如铅、砷、镉、钡、锶和铀。爱荷华大学国家卫生实验室（SHL）招募了1189名参与者参加私人水井研究，以监测砷和其他感兴趣的元素，作为更大监测工作的一部分。1018名参与者收集了水样和尿样，并送到国家卫生实验室进行分析。用于测定水和尿液中元素的分析方法在使用前经过验证，并基于疾病控制和预防中心（CDC）的既定方法。对水样和尿液标本进行了铅、镉、铀、砷、锡、锶、钴、铊、锰、钡、铍、钼、钨、铯、铂和锑的分析。对数据的初步分析表明，井水与尿液中砷、铀和锶浓度之间存在统计学上显著的正相关（Spearman秩序相关系数分别为0.230、0.466和0.314）。镉、铅和其他金属的检测显示与井水没有显著的相关性。在爱荷华州，我们首次发现尿液中的铀与井水中的铀有一定的关联。这表明，人们是通过饮用井水接触到铀的。此外，井水和尿液中砷的相关性显示出微弱的正相关，作为饮用井水暴露于砷的证据。锶在尿液和井水中也有相关性。接触了井水中砷含量达到或高于最大污染物水平（MCL）的参与者，以提高对砷暴露风险的认识。大多数参与者表示，他们正在使用水处理系统，这可能解释了这种弱相关性，并为该地区的公共卫生推广提供了支持性证据。

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引用次数: 0

RETRACTION: PUM2 Promoted Osteoarthritis Progression Through PTEN-Mediated Chondrocyte Ferroptosis by Facilitating NEDD4 mRNA Degradation 撤回：PUM2通过促进NEDD4 mRNA降解，通过PTEN介导的软骨细胞铁下垂促进骨关节炎进展

IF 3.2 3区医学 Q2 ENVIRONMENTAL SCIENCES

Environmental Toxicology

Pub Date : 2025-11-18 DOI: 10.1002/tox.70006

RETRACTION: Y. Meng, L. Chen, Y. Chai, W. Meng, G. Yang, J. Ren, H. Li, P. Qi, J. Chen, and N. Wang, “ PUM2 Promoted Osteoarthritis Progression Through PTEN-Mediated Chondrocyte Ferroptosis by Facilitating NEDD4 mRNA Degradation,” Environmental Toxicology 39, no. 9 (2024): 4318-4332, https://doi.org/10.1002/tox.24310.

The above article, published online on 11 May 2024, in Wiley Online Library (http://onlinelibrary.wiley.com/), has been retracted by agreement between the journal Editor-in-Chief, April Rodd; and Wiley Periodicals LLC. Following publication, duplications were noted in Figure 5. The retraction has been agreed to because of evidence that portions of this figure representing different experimental conditions were duplicated, affecting the interpretation of the data and results presented. The authors did not respond to communications from the Publisher requesting raw data for the experiments in question and an explanation of the concerns. This retraction has been agreed to because the image duplications identified have caused the editors to lose confidence in the results and conclusions presented.

Authors L. Chen, Y. Chai, W. Meng, J. Ren, H. Li, P. Qi, J. Chen and N. Wang did not respond to communications from the Publisher regarding the retraction. Authors Y. Meng and G. Yang could not be reached for comment regarding this retraction.

引用本文：杨刚，任建军，李红华，齐平，陈建军，王宁，“环境毒理学”，第39期。（2024）： 4318‐4332,https://doi.org/10.1002/tox.24310。上述文章于2024年5月11日在线发表在Wiley在线图书馆（http://onlinelibrary.wiley.com/）上，经期刊主编April Rodd；和Wiley期刊有限责任公司。发表后，图5中标注了重复。由于有证据表明此图中代表不同实验条件的部分重复，影响了所呈现的数据和结果的解释，因此同意撤回。作者没有回应出版商要求提供有关实验的原始数据和解释其担忧的通信。本次撤稿已被同意，因为发现的图像重复已导致编辑对所呈现的结果和结论失去信心。作者L. Chen， Y. Chai， W.孟，J. Ren， H. Li， P. Qi， J. Chen和N. Wang没有回应出版商关于撤稿的联系。作者Y.孟和G. Yang无法就此次撤稿发表评论。

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引用次数: 0

Global Fluoride Toxicology Landscape: Bibliometric Approaches and Scientific Mapping 全球氟化物毒理学景观：文献计量方法和科学制图

IF 4.5 3区医学 Q2 ENVIRONMENTAL SCIENCES

Environmental Toxicology

Pub Date : 2025-11-17 DOI: 10.1002/tox.24600

Maria Karolina Martins Ferreira, Deiweson Souza‐Monteiro, Priscila Cunha Nascimento, Luciana Eiró‐Quirino, Leonardo Oliveira Bittencourt, Fatemeh Vida Zohoori, Esperanza Angeles Martinez‐Mier, Marilia Afonso Rabelo Buzalaf, Rafael Rodrigues Lima

This study analyzed research trends in the 100 most‐cited articles on fluoride toxicology, a topic widely debated due to the toxic effects associated with levels deemed safe for human exposure. A bibliometric analysis was conducted using the Web of Science‐Core Collection, extracting data such as citation count, authors, keywords, journal, publication year, country, and continent. After reviewing the studies, additional information—including study design, investigated organs and tissues, main outcomes, and fluoride levels—was obtained. The initial search retrieved 5983 articles, from which the 100 most‐cited were selected, totaling 16 813 citations. The journal Fluoride published the highest number of articles ( n = 9), with keywords like “fluoride,” “fluorosis,” “dental fluorosis,” and “oxidative stress” being the most prevalent. India and China accounted for the largest share of publications. The most common study types were observational studies, literature reviews, and in vitro studies. Several studies reported fluoride's effects on dental and skeletal fluorosis, as well as damage to the brain, thyroid, gastrointestinal tract, heart, liver, kidneys, and specific cell types. This study highlights significant concerns regarding excessive fluoride exposure and identifies key research trends and gaps, particularly in the understanding of molecular mechanisms underlying fluoride‐induced damage.

本研究分析了100篇被引用最多的氟化物毒理学文章的研究趋势，由于与人体暴露安全水平相关的毒性影响，氟化物毒理学是一个广泛争论的话题。使用Web of Science‐Core Collection进行文献计量学分析，提取引文计数、作者、关键词、期刊、出版年份、国家和大洲等数据。在回顾了这些研究之后，获得了更多的信息，包括研究设计、调查的器官和组织、主要结果和氟化物水平。最初的检索检索了5983篇文章，从中选出了被引用次数最多的100篇，共被引用16813次。《氟化物》杂志发表的文章数量最多（n = 9），其中“氟化物”、“氟中毒”、“氟牙症”和“氧化应激”等关键词最为普遍。印度和中国占据了出版物的最大份额。最常见的研究类型是观察性研究、文献综述和体外研究。几项研究报告了氟化物对牙齿和骨骼氟中毒的影响，以及对大脑、甲状腺、胃肠道、心脏、肝脏、肾脏和特定细胞类型的损害。本研究强调了对过量氟化物暴露的重大关注，并确定了关键的研究趋势和差距，特别是在理解氟化物诱导损伤的分子机制方面。

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引用次数: 0

EXPRESSION OF CONCERN: CircWHSC1 Serves as a Prognostic Biomarker and Promotes Malignant Progression of Non-Small-Cell Lung Cancer Via miR-590-5p/SOX5 Axis 关注的表达：CircWHSC1作为预后生物标志物，通过miR‐590‐5p/ SOX5轴促进非小细胞肺癌的恶性进展

IF 3.2 3区医学 Q2 ENVIRONMENTAL SCIENCES

Environmental Toxicology

Pub Date : 2025-11-12 DOI: 10.1002/tox.70001

EXPRESSION OF CONCERN: B. Wu, X. Wang, R. Yu, and X. Xue, “ CircWHSC1 Serves as a Prognostic Biomarker and Promotes Malignant Progression of Non-Small-Cell Lung Cancer Via miR-590-5p/SOX5 Axis,” Environmental Toxicology 38, no. 10 (2023): 2440–2449, https://doi.org/10.1002/tox.23879.

This Expression of Concern is for the above article, published online on 7 July 2023 in Wiley Online Library (http://wileyonlinelibrary.com), and has been issued by agreement between the journal Editor-in-Chief, April Rodd; and Wiley Periodicals LLC. Following publication, concerns were raised regarding the animal experimental data and Figure 2. Discrepancies were noted because the figure shows data beyond the “4 weeks after implantation” described for euthanasia in the main text. Additionally, the authors did not respond to the publisher's request to provide the original data, the ethics approval codes, and proof of patient consent. In the absence of the original data, the journal and publisher are unable to fully investigate the discrepancies. Therefore, the journal has decided to issue an Expression of Concern to inform and alert readers.

关注表达：吴波，王晓霞，于瑞仁，薛晓霞，”，环境毒理学38，no. 1。（2023）： 2440 - 2449, https://doi.org/10.1002/tox.23879。此关注表达是针对上述文章，该文章于2023年7月7日在线发表在Wiley在线图书馆（http://wileyonlinelibrary.com）上，并经期刊主编April Rodd；和Wiley期刊有限责任公司。发表后，人们对动物实验数据和图2提出了担忧。之所以注意到差异，是因为图中显示的数据超出了正文中描述的安乐死的“植入后4周”。此外，作者没有回应出版商提供原始数据、伦理批准代码和患者同意证明的要求。在没有原始数据的情况下，期刊和出版商无法全面调查这些差异。因此，该杂志决定发布一份关注表达，以通知和提醒读者。

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引用次数: 0

RETRACTION: Long Noncoding RNA CASC9 Promotes Pancreatic Cancer Progression by Acting as a ceRNA of miR-497-5p to Upregulate Expression of CCND1 摘要：长链非编码RNA CASC9通过作为miR‐497‐5p的ceRNA上调CCND1的表达来促进胰腺癌的进展

IF 3.2 3区医学 Q2 ENVIRONMENTAL SCIENCES

Environmental Toxicology

Pub Date : 2025-11-12 DOI: 10.1002/tox.70000

RETRACTION: J. Zhou, G. Song, M. Su, H. Zhang, T. Yang, and Z. Song, “ Long Noncoding RNA CASC9 Promotes Pancreatic Cancer Progression by Acting as a ceRNA of miR-497-5p to Upregulate Expression of CCND1,” Environmental Toxicology 38, no. 6 (2023): 1251–1264, https://doi.org/10.1002/tox.23761.

The above article, published online on 22 March 2023, in Wiley Online Library (http://onlinelibrary.wiley.com/), has been retracted by agreement between the journal Editor-in-Chief, April Rodd; and Wiley Periodicals LLC. Following publication, duplications were noted in Figures 6G; in multiple panels within Figures 6F and 5O; in multiple panels between Figures 2D and 5O; and between Figures 4J and 5O. Additionally, the western blots in Figure 6H were duplicated from an earlier publication by different authors (Tang et al., 2020 [https://doi.org/10.18632/aging.103833]); Figure 3B is duplicated from an earlier publication by different authors (Zhou et al., 2020 [https://doi.org/10.2147/CMAR.S276297]); and Figure 5E is duplicated from an earlier publication by different authors (Yang et al., 2019 [https://doi.org/10.1186/s11658-019-0192-7]). The retraction has been agreed to because of evidence that significant portions of multiple figures were duplicated, affecting the interpretation of the data and results presented.

The authors agree with the retraction.

引用本文：周建军，宋国光，苏明，张慧，杨涛，宋忠，"，环境毒理学38，no。（2023）： 1251 - 1264, https://doi.org/10.1002/tox.23761。上述文章于2023年3月22日在线发表在Wiley在线图书馆（http://onlinelibrary.wiley.com/）上，经期刊主编April Rodd；和Wiley期刊有限责任公司。出版后，图6G中注明了重复；在图6F和图50内的多个面板中；在图2D和图50之间的多个面板中；介于图4J和图50之间。此外，图6H中的western blots是由不同作者从早期发表的文章中复制的（Tang et al., 2020 [https://doi.org/10.18632/aging.103833]）；图3B复制自不同作者的早期出版物（Zhou et al., 2020 [https://doi.org/10.2147/CMAR.S276297]）；图5E复制自不同作者的早期出版物（Yang et al., 2019 [https://doi.org/10.1186/s11658‐019‐0192‐7]）。由于有证据表明多个数字的重要部分被重复，影响了对所呈现的数据和结果的解释，因此同意撤回。作者同意撤稿。

{"title":"RETRACTION: Long Noncoding RNA CASC9 Promotes Pancreatic Cancer Progression by Acting as a ceRNA of miR-497-5p to Upregulate Expression of CCND1","authors":"","doi":"10.1002/tox.70000","DOIUrl":"10.1002/tox.70000","url":null,"abstract":"\u0000 \u0000 RETRACTION: J. Zhou, G. Song, M. Su, H. Zhang, T. Yang, and Z. Song, “ Long Noncoding RNA CASC9 Promotes Pancreatic Cancer Progression by Acting as a ceRNA of miR-497-5p to Upregulate Expression of CCND1,” Environmental Toxicology 38, no. 6 (2023): 1251–1264, https://doi.org/10.1002/tox.23761.\u0000 The above article, published online on 22 March 2023, in Wiley Online Library (http://onlinelibrary.wiley.com/), has been retracted by agreement between the journal Editor-in-Chief, April Rodd; and Wiley Periodicals LLC. Following publication, duplications were noted in Figures 6G; in multiple panels within Figures 6F and 5O; in multiple panels between Figures 2D and 5O; and between Figures 4J and 5O. Additionally, the western blots in Figure 6H were duplicated from an earlier publication by different authors (Tang et al., 2020 [https://doi.org/10.18632/aging.103833]); Figure 3B is duplicated from an earlier publication by different authors (Zhou et al., 2020 [https://doi.org/10.2147/CMAR.S276297]); and Figure 5E is duplicated from an earlier publication by different authors (Yang et al., 2019 [https://doi.org/10.1186/s11658-019-0192-7]). The retraction has been agreed to because of evidence that significant portions of multiple figures were duplicated, affecting the interpretation of the data and results presented.The authors agree with the retraction.","PeriodicalId":11756,"journal":{"name":"Environmental Toxicology","volume":"41 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/tox.70000","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145492168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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