Environmental toxicology and pharmacology最新文献_第9页

Adipose tissue cadmium concentrations as potential determinants of serum PON1 status in an adult cohort from Southern Spain 脂肪组织镉浓度作为西班牙南部成人队列血清PON1状态的潜在决定因素

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology

Pub Date : 2025-12-01 Epub Date: 2025-09-25 DOI: 10.1016/j.etap.2025.104827

Maria Cruz Gomez Pellin , Eduardo Linares-Ruiz , Javier Esteban , Inmaculada Salcedo-Bellido , Gonca Çakmak , María Eugenia Velasco García , Jose Barril , Suylen Galbán-Velázquez , Celia Pérez-Díaz , Francisco M. Pérez-Carrascosa , Petra Vrhovnik , Željka Fiket , María de la Cruz Pellín , Juan P. Arrebola

Paraoxonase 1 (PON1) is an antiatherogenic enzyme inhibited by environmental stressors such as cadmium (Cd). Thus, this human study aimed to assess (1) the associations between adipose tissue Cd concentrations and serum PON1 status and (2) the influence of the PON1_Q192R phenotype on the susceptibility of PON1 status to Cd. As a continuation from previous work, a subsample from the GraMo cohort (Granada, Spain) was studied. Three PON1 activities using non-organophosphorous substrates {PALS (phenyl acetate in the absence of NaCl), PAHS (phenyl acetate in 2 M NaCl) and CMPA [4-(chloromethyl)phenyl acetate]} were assayed in serum (n = 296) to obtain the three functional PON1_Q192R phenotypes (QQ, QR and RR). Complementarily, Cd concentrations in adipose tissue (n = 226) and information on socio-demographic characteristics, lifestyle, diet and health status acquired by face-to-face interviews were available. The associations between PON1 activities in serum and Cd concentrations in adipose tissue (subset of n = 138) were explored by using linear regression models, which were adjusted for sex, alcohol consumption and PON1_Q192R phenotype. Additionally, benchmark dose (BMD) modelling was performed. Higher adipose tissue Cd concentrations were associated with lower PON1 activities. PON1_Q192R specific susceptibility to Cd increased in the order QQ < QR < RR. The Cd BMD ranges for an averaged subject were 0.002–0.016 and 0.046–0.115 mg_Cd/kg_{adipose-tissue} for RR and QR, respectively. For QQ cases, the BMD were higher than the Cd concentrations found in adipose tissue. These results suggest that part of the increased susceptibility of the RR cases to cardiovascular diseases might putatively be mediated by its higher sensitivity to Cd, with adipose tissue Cd levels serving as a biomarker of chronic exposure.

对氧磷酶1 （PON1）是一种抗动脉粥样硬化酶，可被环境应激因子如镉（Cd）抑制。因此，这项人体研究旨在评估(1)脂肪组织Cd浓度与血清PON1状态之间的关系，(2)PON1Q192R表型对PON1状态对Cd易感性的影响。作为先前工作的延续，研究了来自GraMo队列（西班牙格拉纳达）的子样本。用非有机磷底物{PALS（无NaCl条件下的乙酸苯酯）、PAHS （2M NaCl条件下的乙酸苯酯）和CMPA[4-（氯甲基）乙酸苯酯]}}测定3种PON1在血清中的活性（n = 296），得到3种功能性PON1Q192R表型（QQ、QR和RR）。此外，还可获得脂肪组织中的Cd浓度（n = 226）以及通过面对面访谈获得的有关社会人口特征、生活方式、饮食和健康状况的信息。利用线性回归模型，对性别、酒精摄入量和PON1Q192R表型进行了调整，探讨了血清中PON1活性与脂肪组织中Cd浓度（n = 138个亚组）之间的关系。此外，进行基准剂量（BMD）建模。较高的脂肪组织Cd浓度与较低的PON1活性相关。PON1Q192R对Cd的特异性敏感性以QQ < QR < RR的顺序递增。RR和QR的Cd骨密度平均值分别为0.002-0.016 mg /kg -tissue和0.046-0.115 mg /kg -tissue。在QQ病例中，骨密度高于脂肪组织中的Cd浓度。这些结果表明，RR病例对心血管疾病易感性增加的部分可能是由其对Cd的更高敏感性介导的，脂肪组织Cd水平可作为慢性暴露的生物标志物。

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引用次数: 0

The pollutant naphthalene causes changes in superoxide dismutases (SODs) expression, SOD activity and lipid peroxides in the white shrimp Penaeus vannamei 污染物萘引起凡纳滨对虾超氧化物歧化酶（SOD）表达、SOD活性和脂质过氧化物的变化

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology

Pub Date : 2025-12-01 Epub Date: 2025-10-24 DOI: 10.1016/j.etap.2025.104854

Laura Camacho-Jiménez, Lilia Leyva-Carrillo, Silvia Gómez-Jiménez, Gloria Yepiz-Plascencia

Polycyclic aromatic hydrocarbons (PAHs) are persistent organic pollutants ubiquitous in coastal areas where the shrimp Penaeus vannamei is farmed. PAHs metabolism increases the production of reactive oxygen species (ROS) and causes oxidative damage. Superoxide dismutases (SODs) are important ROS scavengers. However, SODs regulation in response to PAHs has been scarcely studied in crustaceans. In this work, we report a novel extracellular copper-zinc SOD (CuZnSOD) from P. vannamei with a predicted transmembrane region. To investigate the role of shrimp SODs in the response to PAHs, we analyzed the gene expression of CuZnSOD, cytosolic (cMnSOD) and mitochondrial manganese SOD (mMnSOD) in shrimp hepatopancreas, along with the measurement of total SOD activity and lipid peroxidation. We found that NAP induces a rapid increase in oxidative damage to lipids, while causing differential responses in the SOD gene expression and total SOD activity.

多环芳烃（PAHs）是一种持久性有机污染物，在凡纳滨对虾养殖的沿海地区普遍存在。多环芳烃代谢增加活性氧（ROS）的产生并引起氧化损伤。超氧化物歧化酶（sod）是重要的活性氧清除剂。然而，甲壳类动物对多环芳烃对sod调控的研究却很少。在这项工作中，我们报道了一种新的细胞外铜锌超氧化物歧化酶（CuZnSOD），其预测了跨膜区域。为了研究对虾SOD在多环芳烃应答中的作用，我们分析了对虾肝胰腺CuZnSOD、细胞质SOD （cMnSOD）和线粒体锰SOD （mMnSOD）的基因表达，并测定了总SOD活性和脂质过氧化水平。我们发现NAP诱导脂质氧化损伤的快速增加，同时引起SOD基因表达和总SOD活性的差异反应。

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引用次数: 0

Transcriptomic profiling in human lung organoids uncovers metallothionein response as a signature of PHMG-p-induced lung toxicity 人类肺类器官的转录组学分析揭示了金属硫蛋白反应是phmg -p诱导的肺毒性的一个标志。

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology

Pub Date : 2025-12-01 Epub Date: 2025-10-24 DOI: 10.1016/j.etap.2025.104852

Seongmin Kim , Seri Choi , Seung-Yeon Kim , Ji-Won Baek , Chungoo Park , Eun-Mi Kim

The limited ability of animal and cancer cell-based models to recapitulate human-specific responses underscores the need for human-relevant in vitro systems in toxicology. Here, we present a scalable platform for generating human lung organoids from induced pluripotent stem cells (iLOs), providing a physiologically relevant model for respiratory toxicity assessment. To evaluate this model, iLOs were exposed to polyhexamethylene guanidine phosphate (PHMG-p), a disinfectant associated with lung injury. PHMG-p treatment induced fibrotic responses, including upregulation of α-smooth muscle actin and fibronectin. Transcriptomic profiling revealed a coordinated cellular stress response marked by robust induction of metallothionein (MT) genes. Among them, MT1H was highly sensitive and strongly induced, highlighting its potential as an early biomarker of chemically induced lung injury. This human-specific organoid platform enables mechanistic toxicology, early biomarker discovery, and hazard assessment, offering a compelling alternative to animal-based models for evaluating respiratory toxicants.

基于动物和癌细胞的模型概括人类特异性反应的能力有限，这强调了在毒理学中需要与人类相关的体外系统。在这里，我们提出了一个可扩展的平台，用于从诱导多能干细胞（iLOs）中生成人类肺类器官，为呼吸毒性评估提供了一个生理学相关模型。为了评估该模型，将ilo暴露于聚六亚甲基胍磷酸（PHMG-p），这是一种与肺损伤相关的消毒剂。PHMG-p治疗诱导了纤维化反应，包括α-平滑肌肌动蛋白和纤维连接蛋白的上调。转录组学分析揭示了以金属硫蛋白（MT）基因的强大诱导为标志的协调细胞应激反应。其中，MT1H具有高敏感性和强诱导性，突出了其作为化学诱导肺损伤早期生物标志物的潜力。这种人类特异性的类器官平台能够实现机械毒理学、早期生物标志物发现和危害评估，为评估呼吸毒性物质提供了一种令人信服的替代动物模型。

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引用次数: 0

Impact of morphologically tuned silica nanoparticles on the invasive freshwater bivalve Limnoperna fortunei 形态调谐二氧化硅纳米颗粒对入侵淡水双壳动物的影响

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology

Pub Date : 2025-12-01 Epub Date: 2025-10-30 DOI: 10.1016/j.etap.2025.104857

Gabriel O. Ostapchuk , Analía Ale , Victoria S. Andrade , Gisela L. Poletta , Luciana Montalto , Florencia M. Rojas Molina , Martín F. Desimone , Paolo N. Catalano

Silica nanoparticles (SiNP) have a high global production volume, but their toxicity is far from being completely understood. In this study, we synthesized SiNP with distinct morphological features: dense SiNP (dSiNP), conventional mesoporous SiNP (MSN), and two types of flower-like dendritic mesoporous SiNP with a stellate lamellar structure: one using ibuprofen (FLW-IBU) and one using sodium salicylate (FLW-NaSal) as auxiliary templates. To assess their toxicological impact, we conducted a 96-hour bioassay exposing the freshwater bivalve Limnoperna fortunei to 10 µg/mL of these varied SiNP. Exposure to dSiNP increased superoxide dismutase and glutathione S-transferase enzyme activities in the soft tissue of bivalves. Lipid peroxidation levels also augmented following exposure to both dSiNP and MSN. We observed no significant alterations in tissular damage markers across treatments. Neither FLW-IBU nor FLW-NaSal induced any deleterious effect, indicating they are less detrimental to L. fortunei. These findings contribute to the safe-by-design development of nanomaterials.

二氧化硅纳米颗粒（SiNP）的全球产量很高，但其毒性还远未完全了解。在本研究中，我们合成了具有不同形态特征的SiNP：致密SiNP (dSiNP)，常规介孔SiNP (MSN)，以及两种具有星状片层结构的花状树突状SiNP：一种是用布洛芬（FLW-IBU）作为辅助模板，一种是用水杨酸钠（FLW-NaSal）作为辅助模板。为了评估它们的毒理学影响，我们对淡水双壳动物fortunei Limnoperna进行了96小时的生物测定，将这些不同的SiNP暴露在10 µg/mL中。暴露于dSiNP增加了双壳类软体中超氧化物歧化酶和谷胱甘肽s -转移酶的活性。脂质过氧化水平在暴露于dSiNP和MSN后也增加。我们观察到组织损伤标志物在治疗过程中没有显著变化。FLW-IBU和flw -鼻腔均未引起任何有害作用，表明它们对L. fortunei的危害较小。这些发现有助于纳米材料设计安全的发展。

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引用次数: 0

The agony of choice: Advancing sediment hazard assessment by using avoidance behaviour assays with Lumbriculus variegatus 选择的痛苦：利用变异蚓的回避行为分析推进沉积物危害评估。

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology

Pub Date : 2025-12-01 Epub Date: 2025-11-19 DOI: 10.1016/j.etap.2025.104871

Jacqueline Hilgendorf , Vânia Calisto , Diogo N. Cardoso , Joana Fernandes , Diana L.D. Lima , José N. Pinto , Ana Eduardo Rodrigues , Jesper G. Sørensen , Érika M.L. Sousa , Susana Loureiro

Sediments play a key role in chemical partitioning in aquatic ecosystems, acting as sinks for lipophilic and persistent compounds. However, sediment hazard assessment is limited, often underestimating risks by focusing on short-term, lethal endpoints. Behavioural assays, although underused for sediment-dwellers, can provide faster, more sensitive assessments. This study adapted soil avoidance methods for sediment, testing avoidance in Lumbriculus variegatus exposed to lead, bixafen, and fluoxetine. We compared survival with conventional one-compartment (contaminated sediment only) and two-compartment (contaminated vs. control) assays. The two-compartment test detected significant avoidance at concentrations up to 428 times lower than survival and showed effects when conventional assays failed to detect any (e.g., for bixafen). It revealed significant responses at environmentally relevant levels (0.19 mg/kg fluoxetine, 550 mg/kg lead) and provided insights into chemical sensing and non-monotonic dose–response curves. Two-compartment avoidance assays are rapid, sensitive, and relevant for future sediment hazard assessments with potential population-level implications.

沉积物在水生生态系统的化学分配中起着关键作用，作为亲脂性和持久性化合物的汇。然而，沉积物危害评估是有限的，往往低估了风险，专注于短期，致命的终点。行为分析虽然在沉积物居民中没有得到充分利用，但可以提供更快、更敏感的评估。本研究采用了泥沙避土方法，测试了暴露于铅、比沙芬和氟西汀的杂色蚓避土方法。我们比较了传统的单室（仅污染沉积物）和双室（污染与对照）试验的生存率。双室试验检测到明显的逃避，浓度高达生存的428倍，并且在常规试验未能检测到任何（例如，对bixafen）时显示出效果。它揭示了环境相关水平（0.19mg/kg氟西汀，550mg/kg铅）的显著响应，并提供了对化学感应和非单调剂量-响应曲线的见解。双室避免分析快速、敏感，与未来沉积物危害评估相关，具有潜在的人口水平影响。

{"title":"The agony of choice: Advancing sediment hazard assessment by using avoidance behaviour assays with Lumbriculus variegatus","authors":"Jacqueline Hilgendorf , Vânia Calisto , Diogo N. Cardoso , Joana Fernandes , Diana L.D. Lima , José N. Pinto , Ana Eduardo Rodrigues , Jesper G. Sørensen , Érika M.L. Sousa , Susana Loureiro","doi":"10.1016/j.etap.2025.104871","DOIUrl":"10.1016/j.etap.2025.104871","url":null,"abstract":"<div><div>Sediments play a key role in chemical partitioning in aquatic ecosystems, acting as sinks for lipophilic and persistent compounds. However, sediment hazard assessment is limited, often underestimating risks by focusing on short-term, lethal endpoints. Behavioural assays, although underused for sediment-dwellers, can provide faster, more sensitive assessments. This study adapted soil avoidance methods for sediment, testing avoidance in <em>Lumbriculus variegatus</em> exposed to lead, bixafen, and fluoxetine. We compared survival with conventional one-compartment (contaminated sediment only) and two-compartment (contaminated vs. control) assays. The two-compartment test detected significant avoidance at concentrations up to 428 times lower than survival and showed effects when conventional assays failed to detect any (e.g., for bixafen). It revealed significant responses at environmentally relevant levels (0.19 mg/kg fluoxetine, 550 mg/kg lead) and provided insights into chemical sensing and non-monotonic dose–response curves. Two-compartment avoidance assays are rapid, sensitive, and relevant for future sediment hazard assessments with potential population-level implications.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"120 ","pages":"Article 104871"},"PeriodicalIF":4.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145575020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protective effects of N-acetylcysteine and its amide derivative against toxic metals in vitro: Potential alternatives/adjuncts to traditional chelators n -乙酰半胱氨酸及其酰胺衍生物对有毒金属的体外保护作用：传统螯合剂的潜在替代品/辅助剂。

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology

Pub Date : 2025-12-01 Epub Date: 2025-09-24 DOI: 10.1016/j.etap.2025.104825

Thomas W. Sawyer, Yanfeng Song

The protective efficacies of N-acetylcysteine (NAC) and N-acetylcysteine amide (NACA) against the toxicity of compounds containing arsenic, cadmium, cobalt, chromium and mercury, were compared to those of dimercaprol, dimercaptosuccinic acid, 2,3-dimercaptopropanesulphonate, D-penicillamine, and derivatives of ethylenediamine tetraacetic acid and diethylenetriaminepentaacetic in CHO-K1 cells. Both NAC and NACA were found to confer protection against these metals, with comparable or better efficacy than many of the test chelators. Results from studies using the glutathione synthesis inhibitor buthionine sulphoximine were consistent with NAC/NACA protection being mediated through both GSH up-regulation and chelation. Given NAC’s activity against metal toxicity, widespread clinical use, parenteral or oral routes of administration, high clinical safety, low cost and ease of accessibility, it should be given consideration as a broad-spectrum protectant against toxic metal poisoning as a treatment or adjunct/combination treatment. Its more lipophilic derivative NACA, also warrants attention, especially in those cases where brain toxicity is a concern.

研究了n -乙酰半胱氨酸（NAC）和n -乙酰半胱氨酸酰胺（NACA）对含砷、镉、钴、铬和汞的化合物的保护作用，并与二巯基丙二酸、2,3-二巯基丙磺酸、d -青霉胺以及乙二胺四乙酸和二乙烯三胺五乙酸衍生物对CHO-K1细胞的保护作用进行了比较。NAC和NACA都被发现对这些金属具有保护作用，其效果与许多测试螯合剂相当或更好。使用谷胱甘肽合成抑制剂丁硫氨酸亚砜胺的研究结果与通过谷胱甘肽上调和螯合介导的NAC/NACA保护一致。鉴于NAC抗金属毒性的活性，广泛的临床应用，肠外或口服给药途径，高临床安全性，低成本和易于获取，应考虑将其作为一种广谱保护剂，用于治疗或辅助/联合治疗中毒性金属中毒。其更亲脂的衍生物NACA也值得关注，特别是在那些涉及脑毒性的情况下。

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引用次数: 0

The role of lipid metabolism and peroxisome proliferator activation in mediating pro-cancer phenotypes of poly- and perfluoroalkyl substances in testicular cancer 脂质代谢和过氧化物酶体增殖体激活在睾丸癌中多氟烷基和全氟烷基物质促癌表型中的作用

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology

Pub Date : 2025-12-01 Epub Date: 2025-11-12 DOI: 10.1016/j.etap.2025.104866

Raya I. Boyd , Doha Shokry, Brayden C. Rennels, Younan Adam, Christine Powell, Samantha Johnson, Michael J. Spinella, Ratnakar Singh

Poly- and perfluoroalkyl substances (PFAS) are of human health concern as epidemiological studies show significant associations with testicular germ cell tumors (TGCTs). Here, the effects of perfluorooctanesulfonic acid (PFOS), lithium bis(trifluoromethylsulfonyl)imide (HQ-115), and hexafluoropropylene oxide dimer acid (GenX) on TGCT cells were investigated. Concentrations (10 nM to 1 µM) modelled PFAS doses in relevant human exposure ranges and acute and short-term timepoints (18 h and 4 days) captured proximal mechanisms of action. Metabolomic studies revealed that HQ-115 altered metabolites associated with steroid biosynthesis and lipid metabolism. Peroxisome-proliferator activation receptor (PPAR) target gene expression was altered upon HQ-115 and GenX exposure. Lastly, PFAS exposure altered the activity of PPARs, in TGCT cells, with the most prominent effects being antagonist activity toward PPARγ. These data support that PFAS may act as fatty acid mimics to modulate fatty acid metabolic and steroidogenic endocrine outcome leading to pro-cancer phenotypes in TGCTs.

多氟烷基和全氟烷基物质（PFAS）是人类健康关注的问题，因为流行病学研究表明它们与睾丸生殖细胞肿瘤（tgct）有显著关联。本实验研究了全氟辛烷磺酸（PFOS）、双（三氟甲基磺酰基）亚胺锂（HQ-115）和六氟环氧丙烷二聚酸（GenX）对TGCT细胞的影响。浓度（10 nM至1 µM）模拟了相关人体暴露范围和急性和短期时间点（18 h和4天）的PFAS剂量，捕获了近端作用机制。代谢组学研究表明，HQ-115改变了与类固醇生物合成和脂质代谢相关的代谢物。过氧化物酶体增殖物激活受体（PPAR）靶基因表达在红旗115和GenX暴露后发生改变。最后，PFAS暴露改变了TGCT细胞中ppar的活性，最显著的影响是对PPARγ的拮抗剂活性。这些数据支持PFAS可能作为脂肪酸模拟物调节脂肪酸代谢和甾体源性内分泌结果，导致tgct的癌前表型。

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引用次数: 0

Reproduction, growth, and survival responses of Eisenia fetida and Folsomia candida to individual and combined pesticide exposures 恶臭Eisenia fetida和假丝酵母菌（Folsomia candida）对单独和联合农药暴露的繁殖、生长和生存反应。

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology

Pub Date : 2025-12-01 Epub Date: 2025-10-09 DOI: 10.1016/j.etap.2025.104844

Iwona Gruss , Irmina Ćwieląg-Piasecka , Paulina Bączek , Jacek Twardowski , Szymon Jędrzejewski , Kamila Twardowska , Joanna Magiera-Dulewicz

This study evaluated six widely used pesticides—two insecticides (acetamiprid, pirimicarb), two herbicides (glyphosate, fluroxypyr), and two fungicides (azoxystrobin, tebuconazole)—on the earthworm Eisenia fetida and the springtail Folsomia candida at field-realistic concentrations. Toxicity was assessed through reproduction, growth, and survival. Pirimicarb strongly impaired springtail growth and reproduction, while fluroxypyr and azoxystrobin reduced springtail reproduction. In earthworms, pirimicarb alone slightly decreased reproduction. Mixtures of acetamiprid, fluroxypyr, and azoxystrobin intensified toxicity in both species, while acetamiprid + tebuconazole also affected springtail growth and earthworm reproduction. In contrast, mixtures containing glyphosate mitigated toxic effects, increasing earthworm reproduction and springtail growth. Mortality in springtails was high for several treatments. These results demonstrate that pesticides pose significant risks to soil fauna and that interactions in mixtures can be synergistic or antagonistic, highlighting the need for mixture-specific risk assessments under environmentally realistic conditions.

本研究评估了六种广泛使用的农药——两种杀虫剂（啶虫脒、吡虫威）、两种除草剂（草甘膦、氟虫腈）和两种杀菌剂（嘧菌酯、戊唑唑）——在田间实际浓度下对蚯蚓和春尾假丝虫的杀灭效果。通过繁殖、生长和存活来评估毒性。吡虫威严重损害了春尾虫的生长和繁殖，氟虫灵和嘧菌酯则降低了春尾虫的繁殖。在蚯蚓中，吡虫威单独使用会略微减少繁殖。啶虫脒、氟虫腈和唑虫酯混合使用对两种蚯蚓的毒性均有增强作用，而啶虫脒+苯唑唑对蚯蚓的生长和繁殖也有影响。相比之下，含有草甘膦的混合物减轻了毒性作用，增加了蚯蚓的繁殖和春尾的生长。几种处理的弹尾虫死亡率都很高。这些结果表明，农药对土壤动物构成重大风险，并且混合物中的相互作用可以是协同的或拮抗的，突出了在环境现实条件下对混合物进行特定风险评估的必要性。

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引用次数: 0

Effects of endocrine disruptive chemicals (EDCs) and therapeutic approaches to the polycystic ovary syndrome (PCOS): A current state-of-the-art 内分泌干扰化学物质（EDCs）的影响和多囊卵巢综合征（PCOS）的治疗方法：目前的最新进展。

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology

Pub Date : 2025-12-01 Epub Date: 2025-10-09 DOI: 10.1016/j.etap.2025.104842

Adèle Lemogne Robert , Edite Oliveira Torres , Catarina Jota Baptista

Polycystic ovary syndrome (PCOS) is an endocrine condition affecting women of reproductive age, characterized by hyperandrogenism, ovulatory dysfunction, and some metabolic disturbances. Emerging evidence has been suggesting a link between certain endocrine-disrupting chemicals (EDCs), such as bisphenol A (BPA) and phthalates, and the pathogenesis and/or exacerbation of PCOS. These exogenous compounds interfere with hormonal function, potentially inducing epigenetic modifications and disrupting insulin sensitivity, primarily when exposure occurs during specific periods. This review explores the role of EDCs in the onset and progression of the condition, and it also outlines current therapeutic strategies, including hormonal contraceptives, insulin sensitizers, ovulation induction agents, and anti-androgenic treatments. Novel approaches targeting gut microbiota, cytokine modulation, and antioxidant therapies are discussed, alongside preventive measures to reduce EDC exposure. Thus, this review highlights the need for a personalized, multimodal management of PCOS, integrating pharmacological, lifestyle, and behavioural intervention. Nevertheless, for some of these therapies, it also emphasizes some lack of causality, as well as limited clinical trial data to support their efficacy.

多囊卵巢综合征（PCOS）是一种影响育龄妇女的内分泌疾病，以雄激素过多、排卵功能障碍和一些代谢紊乱为特征。新出现的证据表明，某些内分泌干扰化学物质（EDCs），如双酚a （BPA）和邻苯二甲酸酯，与多囊卵巢综合征的发病和/或恶化之间存在联系。这些外源性化合物干扰激素功能，潜在地诱发表观遗传修饰和破坏胰岛素敏感性，主要发生在特定时期。这篇综述探讨了EDCs在该疾病的发生和发展中的作用，并概述了目前的治疗策略，包括激素避孕药、胰岛素增敏剂、促排卵剂和抗雄激素治疗。讨论了针对肠道微生物群、细胞因子调节和抗氧化治疗的新方法，以及减少EDC暴露的预防措施。因此，本综述强调了对多囊卵巢综合征进行个性化、多模式管理的必要性，包括药物、生活方式和行为干预。然而，对于其中一些疗法，它也强调缺乏因果关系，以及有限的临床试验数据来支持其疗效。

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引用次数: 0

Investigation of N-desmethyl-acetamiprid-induced neurotransmitter disturbances in cerebrospinal fluid from leukemia patients n -去甲基乙酰脒致白血病患者脑脊液神经递质紊乱的研究

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology

Pub Date : 2025-12-01 Epub Date: 2025-10-30 DOI: 10.1016/j.etap.2025.104858

Mengya Si , Muhammad Nadeem Khan , Hazrat Bilal , Muhammad Shafiq , Sabir Khan , Xiaoling Guo , Meimei Wang , Jilong Wu , Wang Zhen , Fen Yao , Adela Jing Li , Xiaoyang Jiao

Neonicotinoids (NEOs) and their metabolites impact neuronal function; however, their effects on neurotransmitters remain unexplored. We analyzed cerebrospinal fluid (CSF) from leukemia patients with differing concentrations of N-desmethyl-acetamiprid (N-dm-ACE) for neurotransmitter profiling. Neurotransmitters and biomarkers were measured in CSF, blood, and serum from 39 patients (19 low and 20 high N-dm-ACE) across three age groups: children, adults, and elders. Significant differences (p ≤ 0.05) in neurotransmitters were found among groups, including glutamic acid (253.45 ± 388.16 & 101.11 ± 52.79), aspartic acid (79.64 ± 87.46 & 0.00), tryptophan (325.89 ± 76.47 & 508.09 ± 331.35), and tyrosine (984.41 ± 348.78 ng/mL). Regression analysis indicated that N-dm-ACE is significantly (p < 0.05) positively associated with serum total proteins and negatively with betaine-aldehyde-chloride and ornithine. This suggests that increased accumulation of N-dm-ACE in the CNS may elevate the risk of neurological or neurotoxic conditions. Further studies are needed to better understand the intricate relationship between NEOs, particularly N-dm-ACE, and brain health.

新烟碱及其代谢物对神经元功能的影响然而，它们对神经递质的影响仍未被探索。我们分析了不同浓度n -去甲基-乙酰氨嘧啶（N-dm-ACE）白血病患者的脑脊液（CSF）的神经递质谱。对来自儿童、成人和老年人三个年龄组的39例患者（19例低N-dm-ACE， 20例高N-dm-ACE）的脑脊液、血液和血清中的神经递质和生物标志物进行了测量。显著差异(p ≤0.05 )在神经递质组织中被发现,包括谷氨酸(253.45 ± 388.16和101.11 ±52.79 )、天冬氨酸(79.64 ± 87.46和0.00),色氨酸(325.89 ± 76.47和508.09 ±331.35 ),和酪氨酸(984.41 ±348.78  ng / mL)。回归分析表明，N-dm-ACE与血清总蛋白呈显著正相关（p <； 0.05），与甜菜碱醛-氯和鸟氨酸呈显著负相关。这表明N-dm-ACE在中枢神经系统中积累的增加可能会增加神经系统或神经毒性疾病的风险。需要进一步的研究来更好地理解neo，特别是N-dm-ACE与大脑健康之间的复杂关系。

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