European Child & Adolescent Psychiatry最新文献

Background: Adolescence is a critical developmental period characterized by significant challenges, a time of "storm and stress". The complex system of multidimensional mental health problems may vary across early, middle, and late adolescence due to the distinctive developmental tasks. However, previous efforts to identify prevention and treatment targets mainly focused on limited aspects of such a system and lacked age-specific considerations.

Objective: This study aims to identify pivotal age-tailored treatment and prevention targets for multidimensional mental health problems through dynamic simulation.

Methods: Three stage-specific between-subject networks were constructed to model mental health problems, using data from 80,113 Chinese adolescents. In silico intervention was implemented on these networks to identify particular symptoms that, if targeted, would prove most effective in either preventing (via aggravating simulation) or treating (via alleviating simulation) mental health issues within the mental health system.

Results: Stage-specific in silico intervention analysis revealed that, during early adolescence, academic stress and interpersonal sensitivity were the most effective targets in aggravating and alleviating interventions, respectively. In middle and late adolescence, anxiety emerged as the most significant target for aggravation, while emotional disturbance demonstrated the greatest alleviating effect.

Conclusions and implications: Academic stress experienced during early adolescence and anxiety prevalent in middle to late adolescence are recommended as primary prevention targets. Interpersonal sensitivity emerges as the most effective treatment target for early adolescents, whereas emotional disturbance should be prioritized for middle to late adolescents.

Atypical error responses characterize pediatric anxiety disorders. Error responses are considerably influenced by situational factors such as social context, which typically elicits enhanced error responses. This study investigates the impact of social context on the neural correlates of error processing and how individual differences in anxiety symptoms and naturalistically-sampled daily worry influences these associations. Sixty-two youth (32 with an anxiety disorder, 30 healthy controls; M_age =13.9 +/- 2.7, 61% female) underwent functional magnetic resonance imaging while completing a flanker task in both peer and alone context. Anxiety symptoms were measured using Screen for Child Anxiety Related Disorders, and daily worry was measured using ecological momentary assessment. Diagnosis inclusions were only used to ensure enriched sample for symptoms dimensions of anxiety but not used as a grouping criteria. The presence of a simulated peer was associated with decreased activity in the precuneus, mid-orbital gyrus, and parahippocampal gyrus/amygdala during error processing. In youth with higher anxiety symptom severity, the presence of a peer was associated with decreased activity in the superior/middle temporal gyrus and middle frontal gyrus. In contrast, for youth rating higher levels of daily worries, the presence of a peer was associated with increased activity in the inferior frontal gyrus and middle cingulate cortex. Findings highlight the importance of social context in error processing. Results further suggest that anxiety and worry differentially modulate neural responses in the presence of a peer.