Pub Date : 2026-01-27DOI: 10.1016/j.eujim.2026.102622
Botan Xu , Fen Zhou , Guangyi Yang , Ziwei Wang , Zihan Zhao , Yishan Yu , Hao Wang , Bingjie Liu , Ting Yuan , Yuxi Wang
Introduction
Our overview aimed to evaluate the methodological quality, completeness of reporting, and evidence quality of systematic reviews (SRs) on the intervention of external therapy of traditional Chinese medicine (TCM) for Rheumatoid Arthritis (RA).
Methods
A computer-based search was conducted across four Chinese and three English databases from inception to November 30, 2025. For 33 pairwise meta-analyses, Assessing the Methodological Quality of Systematic Reviews 2 (AMSTAR 2) and Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 (PRISMA 2020) were used for methodological and reporting quality assessment; five network meta-analyses used ISPOR-AMCP-NPC questionnaire and PRISMA Network Meta-analysis (NMA) extension statement. Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system was used to assess the evidence quality, with Corrected Covered Area (CCA) analyzing original study duplication.
Results
A total of 38 SRs were included, with the AMSTAR 2 evaluation showing three SRs rated as moderate quality, 19 as low quality, and 11 as very low quality. The methodological quality of the network meta-analysis also has some flaws. The PRISMA 2020 statement and PRISMA NMA extension statement indicated that certain items in the included SRs were incomplete. The GRADE system assessment showed that the quality of results for SRs was mostly low or very low. The CCA was 0.013, indicating a low duplication rate of the original studies.
Conclusion
External therapies of TCM could improve the symptoms and signs of RA and have fewer side effects, with higher safety. However, the methodological quality, completeness of reporting, and evidence quality of the included SRs were relatively low, which had some impact on the accuracy of the results. Further studies with larger sample sizes and higher quality are needed.
{"title":"External therapy of traditional Chinese medicine for rheumatoid arthritis: An overview of systematic reviews","authors":"Botan Xu , Fen Zhou , Guangyi Yang , Ziwei Wang , Zihan Zhao , Yishan Yu , Hao Wang , Bingjie Liu , Ting Yuan , Yuxi Wang","doi":"10.1016/j.eujim.2026.102622","DOIUrl":"10.1016/j.eujim.2026.102622","url":null,"abstract":"<div><h3>Introduction</h3><div>Our overview aimed to evaluate the methodological quality, completeness of reporting, and evidence quality of systematic reviews (SRs) on the intervention of external therapy of traditional Chinese medicine (TCM) for Rheumatoid Arthritis (RA).</div></div><div><h3>Methods</h3><div>A computer-based search was conducted across four Chinese and three English databases from inception to November 30, 2025. For 33 pairwise meta-analyses, Assessing the Methodological Quality of Systematic Reviews 2 (AMSTAR 2) and Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 (PRISMA 2020) were used for methodological and reporting quality assessment; five network meta-analyses used ISPOR-AMCP-NPC questionnaire and PRISMA Network Meta-analysis (NMA) extension statement. Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system was used to assess the evidence quality, with Corrected Covered Area (CCA) analyzing original study duplication.</div></div><div><h3>Results</h3><div>A total of 38 SRs were included, with the AMSTAR 2 evaluation showing three SRs rated as moderate quality, 19 as low quality, and 11 as very low quality. The methodological quality of the network meta-analysis also has some flaws. The PRISMA 2020 statement and PRISMA NMA extension statement indicated that certain items in the included SRs were incomplete. The GRADE system assessment showed that the quality of results for SRs was mostly low or very low. The CCA was 0.013, indicating a low duplication rate of the original studies.</div></div><div><h3>Conclusion</h3><div>External therapies of TCM could improve the symptoms and signs of RA and have fewer side effects, with higher safety. However, the methodological quality, completeness of reporting, and evidence quality of the included SRs were relatively low, which had some impact on the accuracy of the results. Further studies with larger sample sizes and higher quality are needed.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"83 ","pages":"Article 102622"},"PeriodicalIF":1.7,"publicationDate":"2026-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146102400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-24DOI: 10.1016/j.eujim.2026.102621
Yuqin Yang, Xuejia Li, Bo Zhu, Shilei Song, Shengyi Feng, Bo Li
Introduction
Steroid-induced osteonecrosis of the femoral head (SONFH) is a severe condition caused by impaired blood supply due to steroid use. This compromised vascularization leads to the death of bone tissue, resulting in pain, functional impairment, and eventual joint collapse. Tongluo Shenggu Capsule (TLSGC) has shown promise as a joint-preserving treatment, yet its underlying mechanisms remain unclear. This study aims to evaluate the efficacy and safety of TLSGC and to elucidate its mechanisms of action in SONFH.
Methods
This open-label, randomized, non-inferiority controlled trial will be conducted in the Department of Joint Surgery at Yueyang Hospital of Integrated Traditional Chinese and Western Medicine. A total of 224 eligible patients with ARCO stage II SONFH will be randomly assigned in a 1:1 ratio to receive either Tongluo Shenggu Capsule (TLSGC) or alendronate sodium. The intervention period will span two courses, each lasting three months. The primary outcome is the change in the radiological efficacy score. Secondary outcomes include the clinical efficacy rate, serum biomarkers (VEGF, IL-1β, IL-6, TNF-α, TGF-β, BMP-2, HIF-1α, P1NP), Harris Hip Score, pain Visual Analogue Scale score, hip flexion range of motion, walking distance, and quality of life (assessed by the EQ-5D-5 L). Safety will be monitored via complete blood count, liver and kidney function tests, urinalysis, and stool examination. All statistical analyses will be performed using SPSS, with a significance level set at P ≤ 0.05.
Conclusions
This study will evaluate the therapeutic potential of TLSGC for ARCO stage II SONFH. The intervention is designed to target both pathological mechanisms and bone repair processes. Alendronate was selected as the active comparator for its established bone-protective properties, enabling an assessment of TLSGC's comparable efficacy within a recognized therapeutic framework. Should TLSGC demonstrate non-inferiority, it would represent a complementary TCM strategy. The generalizability of the findings may be limited to Chinese populations, indicating a need for future validation in more diverse ethnic cohorts.
Trial registration
ITMCTR, ITMCTR2024000431. Registered 23 August 2024.
{"title":"Tongluo Shenggu Capsules for treating steroid-induced osteonecrosis of the femoral head in ARCO stage II: A study protocol for a randomized controlled trial","authors":"Yuqin Yang, Xuejia Li, Bo Zhu, Shilei Song, Shengyi Feng, Bo Li","doi":"10.1016/j.eujim.2026.102621","DOIUrl":"10.1016/j.eujim.2026.102621","url":null,"abstract":"<div><h3>Introduction</h3><div>Steroid-induced osteonecrosis of the femoral head (SONFH) is a severe condition caused by impaired blood supply due to steroid use. This compromised vascularization leads to the death of bone tissue, resulting in pain, functional impairment, and eventual joint collapse. Tongluo Shenggu Capsule (TLSGC) has shown promise as a joint-preserving treatment, yet its underlying mechanisms remain unclear. This study aims to evaluate the efficacy and safety of TLSGC and to elucidate its mechanisms of action in SONFH.</div></div><div><h3>Methods</h3><div>This open-label, randomized, non-inferiority controlled trial will be conducted in the Department of Joint Surgery at Yueyang Hospital of Integrated Traditional Chinese and Western Medicine. A total of 224 eligible patients with ARCO stage II SONFH will be randomly assigned in a 1:1 ratio to receive either Tongluo Shenggu Capsule (TLSGC) or alendronate sodium. The intervention period will span two courses, each lasting three months. The primary outcome is the change in the radiological efficacy score. Secondary outcomes include the clinical efficacy rate, serum biomarkers (VEGF, IL-1β, IL-6, TNF-α, TGF-β, BMP-2, HIF-1α, P1NP), Harris Hip Score, pain Visual Analogue Scale score, hip flexion range of motion, walking distance, and quality of life (assessed by the EQ-5D-5 L). Safety will be monitored via complete blood count, liver and kidney function tests, urinalysis, and stool examination. All statistical analyses will be performed using SPSS, with a significance level set at P ≤ 0.05.</div></div><div><h3>Conclusions</h3><div>This study will evaluate the therapeutic potential of TLSGC for ARCO stage II SONFH. The intervention is designed to target both pathological mechanisms and bone repair processes. Alendronate was selected as the active comparator for its established bone-protective properties, enabling an assessment of TLSGC's comparable efficacy within a recognized therapeutic framework. Should TLSGC demonstrate non-inferiority, it would represent a complementary TCM strategy. The generalizability of the findings may be limited to Chinese populations, indicating a need for future validation in more diverse ethnic cohorts.</div></div><div><h3>Trial registration</h3><div>ITMCTR, ITMCTR2024000431. Registered 23 August 2024.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"83 ","pages":"Article 102621"},"PeriodicalIF":1.7,"publicationDate":"2026-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146172405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The ketogenic diet (KD) has attracted increasing attention for its potential to modulate the gut microbiota; however, the rapidly expanding literature makes it difficult to identify dominant themes, leading contributors, and research gaps. This study aimed to map global research trends on the KD–gut microbiota relationship using bibliometric methods.
Methods
A bibliometric analysis was conducted using the Scopus database. Records published between January 1, 2009 and December 31, 2024 were included (search updated to January 1, 2025). Bibliometric indicators and performance analyses were computed, and keyword co-occurrence and international collaboration networks were visualized using VOSviewer.
Results
A total of 404 documents were identified. Publication output increased markedly after 2016 and peaked in 2024, indicating growing scientific interest. The most prolific authors and institutions contributed disproportionately to the field, and thematic mapping revealed five dominant clusters, including neurodegenerative diseases, metabolic regulation, and microbiota-related mechanisms. While the field is expanding, the distribution of document types suggests that conceptual and synthesis work remains prominent.
Conclusion
Research on the KD–gut microbiota relationship has grown substantially over the last decade, with clear thematic consolidation around metabolic and neurological outcomes. Future studies should prioritize mechanistic and longitudinal clinical designs and integrate multi-omics approaches to clarify causal pathways and support personalized dietary interventions.
{"title":"Global research trends on the ketogenic diet–gut microbiota relationship: A bibliometric analysis","authors":"Emre Manisalı , Kaan Zıkşahna , Rumeysa Adıyıl , Murat Ihlamur","doi":"10.1016/j.eujim.2026.102615","DOIUrl":"10.1016/j.eujim.2026.102615","url":null,"abstract":"<div><h3>Introduction</h3><div>The ketogenic diet (KD) has attracted increasing attention for its potential to modulate the gut microbiota; however, the rapidly expanding literature makes it difficult to identify dominant themes, leading contributors, and research gaps. This study aimed to map global research trends on the KD–gut microbiota relationship using bibliometric methods.</div></div><div><h3>Methods</h3><div>A bibliometric analysis was conducted using the Scopus database. Records published between January 1, 2009 and December 31, 2024 were included (search updated to January 1, 2025). Bibliometric indicators and performance analyses were computed, and keyword co-occurrence and international collaboration networks were visualized using VOSviewer.</div></div><div><h3>Results</h3><div>A total of 404 documents were identified. Publication output increased markedly after 2016 and peaked in 2024, indicating growing scientific interest. The most prolific authors and institutions contributed disproportionately to the field, and thematic mapping revealed five dominant clusters, including neurodegenerative diseases, metabolic regulation, and microbiota-related mechanisms. While the field is expanding, the distribution of document types suggests that conceptual and synthesis work remains prominent.</div></div><div><h3>Conclusion</h3><div>Research on the KD–gut microbiota relationship has grown substantially over the last decade, with clear thematic consolidation around metabolic and neurological outcomes. Future studies should prioritize mechanistic and longitudinal clinical designs and integrate multi-omics approaches to clarify causal pathways and support personalized dietary interventions.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"82 ","pages":"Article 102615"},"PeriodicalIF":1.7,"publicationDate":"2026-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146024084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-09DOI: 10.1016/j.eujim.2026.102613
Lijun Pang , Yunfei Li , Lili Cheng , Junjie Chen , Ziheng Zhu , Zhongfu Tang , Chuanbing Huang
Introduction
Ankylosing spondylitis (AS) is a chronic inflammatory spondyloarthritis in which pharmacologic therapy alone often leaves residual pain, stiffness and functional limitation. Wuqinxi (Five-Animal Exercise) is a traditional Chinese mind–body practice that may provide anti-inflammatory and mobility benefits. This trial evaluated the add-on effects of a 12-week Wuqinxi programme combined with standard pharmacologic therapy on clinical, biomarker and imaging outcomes in patients with AS.
Methods
In this single-centre, randomized, parallel-group trial, 64 adults with AS receiving stable celecoxib and sulfasalazine were allocated to Wuqinxi plus standard care or standard care alone for 12 weeks. The primary outcome was change in Bath Ankylosing Spondylitis Disease Activity Index (BASDAI). Key secondary outcomes were Bath Ankylosing Spondylitis Functional and Metrology Indices (BASFI, BASMI), spinal pain (visual analogue scale), and radiographic and MRI scores (modified Stoke Ankylosing Spondylitis Spinal Score [mSASSS], Spondyloarthritis Research Consortium of Canada [SPARCC] sacroiliac joint score). Analyses followed the intention-to-treat principle and are reported as between-group mean differences in change with 95% confidence intervals (CIs).
Results
BASDAI improved in both groups but more with Wuqinxi (mean change −2.6 vs −2.1; between-group difference −0.58, 95% CI −1.10 to −0.05). Add-on Wuqinxi yielded larger gains in physical function and spinal mobility (BASFI difference −1.35, 95% CI −1.93 to −0.78; BASMI difference −1.63, 95% CI −2.15 to −1.10), and greater reductions in spinal pain (visual analogue scale difference −0.94, 95% CI −1.56 to −0.32). Structural and inflammatory scores also favoured Wuqinxi (mSASSS difference −5.31, 95% CI −8.49 to −2.14; SPARCC difference −6.31, 95% CI −8.59 to −4.04), accompanied by consistent improvements in health-related quality of life, spinal mobility measures and inflammatory biomarkers. No serious adverse events occurred; mild musculoskeletal soreness and gastrointestinal discomfort were infrequent and self-limited in both groups.
Conclusions
A 12-week, partially supervised Wuqinxi programme as an add-on to standard pharmacologic therapy improved disease activity, function, spinal mobility, quality of life, inflammatory biomarkers and MRI inflammation in patients with AS, with good short-term safety. Larger and longer trials are needed to confirm durability and structural benefits.
{"title":"Add-on effects of five-animal exercise in ankylosing spondylitis: A randomized controlled trial","authors":"Lijun Pang , Yunfei Li , Lili Cheng , Junjie Chen , Ziheng Zhu , Zhongfu Tang , Chuanbing Huang","doi":"10.1016/j.eujim.2026.102613","DOIUrl":"10.1016/j.eujim.2026.102613","url":null,"abstract":"<div><h3>Introduction</h3><div>Ankylosing spondylitis (AS) is a chronic inflammatory spondyloarthritis in which pharmacologic therapy alone often leaves residual pain, stiffness and functional limitation. Wuqinxi (Five-Animal Exercise) is a traditional Chinese mind–body practice that may provide anti-inflammatory and mobility benefits. This trial evaluated the add-on effects of a 12-week Wuqinxi programme combined with standard pharmacologic therapy on clinical, biomarker and imaging outcomes in patients with AS.</div></div><div><h3>Methods</h3><div>In this single-centre, randomized, parallel-group trial, 64 adults with AS receiving stable celecoxib and sulfasalazine were allocated to Wuqinxi plus standard care or standard care alone for 12 weeks. The primary outcome was change in Bath Ankylosing Spondylitis Disease Activity Index (BASDAI). Key secondary outcomes were Bath Ankylosing Spondylitis Functional and Metrology Indices (BASFI, BASMI), spinal pain (visual analogue scale), and radiographic and MRI scores (modified Stoke Ankylosing Spondylitis Spinal Score [mSASSS], Spondyloarthritis Research Consortium of Canada [SPARCC] sacroiliac joint score). Analyses followed the intention-to-treat principle and are reported as between-group mean differences in change with 95% confidence intervals (CIs).</div></div><div><h3>Results</h3><div>BASDAI improved in both groups but more with Wuqinxi (mean change −2.6 vs −2.1; between-group difference −0.58, 95% CI −1.10 to −0.05). Add-on Wuqinxi yielded larger gains in physical function and spinal mobility (BASFI difference −1.35, 95% CI −1.93 to −0.78; BASMI difference −1.63, 95% CI −2.15 to −1.10), and greater reductions in spinal pain (visual analogue scale difference −0.94, 95% CI −1.56 to −0.32). Structural and inflammatory scores also favoured Wuqinxi (mSASSS difference −5.31, 95% CI −8.49 to −2.14; SPARCC difference −6.31, 95% CI −8.59 to −4.04), accompanied by consistent improvements in health-related quality of life, spinal mobility measures and inflammatory biomarkers. No serious adverse events occurred; mild musculoskeletal soreness and gastrointestinal discomfort were infrequent and self-limited in both groups.</div></div><div><h3>Conclusions</h3><div>A 12-week, partially supervised Wuqinxi programme as an add-on to standard pharmacologic therapy improved disease activity, function, spinal mobility, quality of life, inflammatory biomarkers and MRI inflammation in patients with AS, with good short-term safety. Larger and longer trials are needed to confirm durability and structural benefits.</div></div><div><h3>Trial registration</h3><div>ITMCTR2024000756.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"82 ","pages":"Article 102613"},"PeriodicalIF":1.7,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146024083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Uterine fibroids are prevalent among women of reproductive age. They have a negative impact on females' private and social life. As surgical and non-surgical approaches lead to some shortcomings such as reproduction failure, recurrence, and adverse effects of medications, complementary and integrative treatments have gained attention. Acupuncture is used for uterine fibroids in practice; however, the evidence is limited. This study aims to compare the effects of segmental electroacupuncture, manual acupuncture, and sham acupuncture on symptoms, mass size, and Doppler indices of uterine arteries in patients with uterine fibroids.
Methods
This study is a three-arm, sham-controlled, parallel-group, single-blinded, randomized clinical trial. Seventy-two cases with uterine fibroids type 1-6 according to the International Federation of Gynecology and Obstetrics classification will enter the study. They will be randomized into 3 groups, segmental electroacupuncture, manual traditional acupuncture and sham acupuncture and undergo an eight-week intervention, then will be followed up for 8 weeks. Fibroid size, uterine arteries’ resistance index, pulsatility index, and diameter; Uterine Fibroid Symptoms and Health-Related Quality of Life (UFS-QOL) questionnaire scores, and adverse events will be compared before and immediately after the intervention, and after 8 weeks follow-up. The outcomes will be reported as statistically significant at a probability level of P value < 0.05.
Results
The results of this protocol will be published in peer-reviewed journals.
Conclusion
This clinical trial will be the first to provide substantial evidence regarding the safety and efficacy of acupuncture in the treatment of uterine fibroids, while also suggesting a mechanism through the analysis of uterine artery indices. Moreover, evaluating the differences in efficacy between segmental and traditional manual acupuncture will further facilitate the optimization of acupuncture methods for uterine fibroids.
{"title":"Acupuncture for uterine fibroids: A protocol for a randomized controlled trial comparing segmental electroacupuncture, manual acupuncture, and sham acupuncture","authors":"Elham Hooshyarazar , Parvaneh layegh , Leili Hafizi , Maliheh Dadgarmoghaddam , Sandro Graca , Amir Hooman Kazemi , Seyed Kazem Farahmand , Farnoosh Bidouee , Hoda Azizi","doi":"10.1016/j.eujim.2026.102614","DOIUrl":"10.1016/j.eujim.2026.102614","url":null,"abstract":"<div><h3>Introduction</h3><div>Uterine fibroids are prevalent among women of reproductive age. They have a negative impact on females' private and social life. As surgical and non-surgical approaches lead to some shortcomings such as reproduction failure, recurrence, and adverse effects of medications, complementary and integrative treatments have gained attention. Acupuncture is used for uterine fibroids in practice; however, the evidence is limited. This study aims to compare the effects of segmental electroacupuncture, manual acupuncture, and sham acupuncture on symptoms, mass size, and Doppler indices of uterine arteries in patients with uterine fibroids.</div></div><div><h3>Methods</h3><div>This study is a three-arm, sham-controlled, parallel-group, single-blinded, randomized clinical trial. Seventy-two cases with uterine fibroids type 1-6 according to the International Federation of Gynecology and Obstetrics classification will enter the study. They will be randomized into 3 groups, segmental electroacupuncture, manual traditional acupuncture and sham acupuncture and undergo an eight-week intervention, then will be followed up for 8 weeks. Fibroid size, uterine arteries’ resistance index, pulsatility index, and diameter; Uterine Fibroid Symptoms and Health-Related Quality of Life (UFS-QOL) questionnaire scores, and adverse events will be compared before and immediately after the intervention, and after 8 weeks follow-up. The outcomes will be reported as statistically significant at a probability level of P value < 0.05.</div></div><div><h3>Results</h3><div>The results of this protocol will be published in peer-reviewed journals.</div></div><div><h3>Conclusion</h3><div>This clinical trial will be the first to provide substantial evidence regarding the safety and efficacy of acupuncture in the treatment of uterine fibroids, while also suggesting a mechanism through the analysis of uterine artery indices. Moreover, evaluating the differences in efficacy between segmental and traditional manual acupuncture will further facilitate the optimization of acupuncture methods for uterine fibroids.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"83 ","pages":"Article 102614"},"PeriodicalIF":1.7,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146102401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-07DOI: 10.1016/j.eujim.2026.102611
Hongsheng Liu , Qi Yang , Guiyuan Pang , Meiyu Huang , Lianxiang Lu , Peiyuan Li , Ben Chen , Lini Huo
Introduction
Network pharmacology is widely used to study the mechanisms of Traditional Chinese Medicine (TCM). However, existing methods do not account for the varying dosages of individual components in TCM formulas, which can affect result reliability. This study aimed to assess the impact of incorporating dosage information into network pharmacology for more accurate evaluation of TCM formulas.
Methods
A quantitative network pharmacology approach was developed by introducing the ‘Score of Quantitative Network Pharmacology’ (SQNP) as an evaluation index. Using Ma Huang Tang (MHT) as a case study, both qualitative and quantitative network pharmacology methods were applied to analyse key targets, Gene Ontology (GO) biological function enrichment, and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment. The effects of dosage weighting were compared across both methods.
Results
The comparative analysis revealed that the quantitative method significantly improved the accuracy of identifying key targets. The top 10 targets were consistent in type but showed a significant change in ranking with the addition of dosage weighting. Biological function and pathway enrichment analysis also demonstrated higher reliability with the quantitative approach. The quantitative network pharmacology method provided a more comprehensive understanding of the therapeutic mechanisms of MHT.
Conclusions
Incorporating dosage information into network pharmacology using the SQNP method enhances the reliability of target identification and biological analysis for TCM formulas, offering a more accurate and scientifically robust evaluation for TCM research.
{"title":"Development of a quantitative network pharmacology approach for TCM formulas: A case study of Ma Huang Tang","authors":"Hongsheng Liu , Qi Yang , Guiyuan Pang , Meiyu Huang , Lianxiang Lu , Peiyuan Li , Ben Chen , Lini Huo","doi":"10.1016/j.eujim.2026.102611","DOIUrl":"10.1016/j.eujim.2026.102611","url":null,"abstract":"<div><h3>Introduction</h3><div>Network pharmacology is widely used to study the mechanisms of Traditional Chinese Medicine (TCM). However, existing methods do not account for the varying dosages of individual components in TCM formulas, which can affect result reliability. This study aimed to assess the impact of incorporating dosage information into network pharmacology for more accurate evaluation of TCM formulas.</div></div><div><h3>Methods</h3><div>A quantitative network pharmacology approach was developed by introducing the ‘Score of Quantitative Network Pharmacology’ (SQNP) as an evaluation index. Using Ma Huang Tang (MHT) as a case study, both qualitative and quantitative network pharmacology methods were applied to analyse key targets, Gene Ontology (GO) biological function enrichment, and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment. The effects of dosage weighting were compared across both methods.</div></div><div><h3>Results</h3><div>The comparative analysis revealed that the quantitative method significantly improved the accuracy of identifying key targets. The top 10 targets were consistent in type but showed a significant change in ranking with the addition of dosage weighting. Biological function and pathway enrichment analysis also demonstrated higher reliability with the quantitative approach. The quantitative network pharmacology method provided a more comprehensive understanding of the therapeutic mechanisms of MHT.</div></div><div><h3>Conclusions</h3><div>Incorporating dosage information into network pharmacology using the SQNP method enhances the reliability of target identification and biological analysis for TCM formulas, offering a more accurate and scientifically robust evaluation for TCM research.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"82 ","pages":"Article 102611"},"PeriodicalIF":1.7,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145975268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-04DOI: 10.1016/j.eujim.2025.102606
Pooja Rani , Neha Chauhan , Sumit Kalra , Ashutosh Ravi Gupta , Sachin Singh , Richard David , Neetha RB , Anandaraman PV
Introduction
The convergence of traditional, complementary, and integrative medicine (TCIM) with contemporary digital health technologies presents a significant opportunity to expand the reach of affordable, evidence-based care. Ayurveda, a key discipline within TCIM, emphasises preventive strategies and lifestyle modifications for long-term health. However, the quality and relevance of mobile applications claiming to offer ayurvedic content remain largely unexamined, raising concerns regarding their efficacy and alignment with user needs.
Objective
This study aimed to systematically evaluate the content and quality of ayurveda-related mobile applications available on the Google Play Store (GPS). The present study also explored associations between app content, user ratings, with standardised quality scores to bring forth future directions.
Methods
A structured search was conducted in April 2024 using the most representative Ayurveda application-based keywords “Ayurveda,” “Ayurved,” and “AYUSH.” Eligible apps were screened to include those that were freely downloaded, non-duplicate, fully functional, and available in Hindi or English. Two trained reviewers independently evaluated apps using the validated Mobile Application Rating Scale (MARS). Correlation analyses were performed to examine the relationships between MARS scores, user ratings, and download counts.
Results
A total of 317 apps were retrieved from the GPS. After screening for duplicates and applying eligibility criteria, 145 applications were evaluated. Most of the apps belonged to the categories of e-books, e-magazines, herbal product shopping apps, coaching apps, home remedies and teleconsultation. The mean overall MARS score was 2.82 ± 0.69, while the app-specific value was 1.60 ± 0.63. Five apps scored >4.0. Functionality achieved the highest rating (3.90 ± 0.57), followed by engagement (2.68 ± 0.75), aesthetics (2.60 ± 1.08), information (2.09 ± 0.54), and subjective quality (1.92 ± 0.62). Inter-rater reliability was high with Cronbach’s alpha at 0.935(95% C.I.). No significant correlation was observed between MARS scores, user ratings, and downloads (p > 0.05).
Conclusion
The current landscape of ayurveda mobile applications lacks adherence to evidence-based content and usability, highlighting the need for collaborative, regulated development.
传统、补充和综合医学（TCIM）与现代数字卫生技术的融合为扩大负担得起的循证护理范围提供了重要机会。阿育吠陀是TCIM中的一门关键学科，强调预防战略和改变生活方式以促进长期健康。然而，声称提供阿育吠陀内容的移动应用程序的质量和相关性在很大程度上仍未得到检验，这引起了人们对其功效和与用户需求的一致性的担忧。目的系统评价谷歌Play Store （GPS）中与阿育吠陀相关的移动应用程序的内容和质量。本研究还探讨了应用内容、用户评分和标准化质量评分之间的关系，以提出未来的发展方向。方法于2024年4月使用最具代表性的基于阿育吠陀应用的关键词“Ayurveda”、“Ayurved”和“AYUSH”进行结构化搜索。合格的应用程序被筛选，包括那些免费下载，非重复，功能齐全，并提供印地语或英语。两名训练有素的评论者使用经过验证的移动应用评级量表（MARS）独立评估应用程序。进行相关性分析以检查MARS分数、用户评分和下载次数之间的关系。结果从GPS中共检索到317个app。经过重复筛选和申请资格标准，145份申请被评估。大多数应用属于电子书、电子杂志、草药产品购物应用、教练应用、家庭疗法和远程咨询等类别。MARS平均总评分为2.82±0.69，应用特异性评分为1.60±0.63。有5款应用获得了4.0分。功能性获得最高评分（3.90±0.57），其次是参与（2.68±0.75），美学（2.60±1.08），信息（2.09±0.54）和主观质量（1.92±0.62）。评价间信度高，Cronbach 's alpha为0.935（95% C.I.）。MARS评分、用户评分和下载量之间无显著相关性（p > 0.05）。目前的阿育吠陀移动应用缺乏对基于证据的内容和可用性的坚持，强调了协作、规范开发的必要性。
{"title":"A systematic review evaluating the quality of Ayurveda smartphone applications (Android)","authors":"Pooja Rani , Neha Chauhan , Sumit Kalra , Ashutosh Ravi Gupta , Sachin Singh , Richard David , Neetha RB , Anandaraman PV","doi":"10.1016/j.eujim.2025.102606","DOIUrl":"10.1016/j.eujim.2025.102606","url":null,"abstract":"<div><h3>Introduction</h3><div>The convergence of traditional, complementary, and integrative medicine (TCIM) with contemporary digital health technologies presents a significant opportunity to expand the reach of affordable, evidence-based care. Ayurveda, a key discipline within TCIM, emphasises preventive strategies and lifestyle modifications for long-term health. However, the quality and relevance of mobile applications claiming to offer ayurvedic content remain largely unexamined, raising concerns regarding their efficacy and alignment with user needs.</div></div><div><h3>Objective</h3><div>This study aimed to systematically evaluate the content and quality of ayurveda-related mobile applications available on the Google Play Store (GPS). The present study also explored associations between app content, user ratings, with standardised quality scores to bring forth future directions.</div></div><div><h3>Methods</h3><div>A structured search was conducted in April 2024 using the most representative Ayurveda application-based keywords “Ayurveda,” “Ayurved,” and “AYUSH.” Eligible apps were screened to include those that were freely downloaded, non-duplicate, fully functional, and available in Hindi or English. Two trained reviewers independently evaluated apps using the validated Mobile Application Rating Scale (MARS). Correlation analyses were performed to examine the relationships between MARS scores, user ratings, and download counts.</div></div><div><h3>Results</h3><div>A total of 317 apps were retrieved from the GPS. After screening for duplicates and applying eligibility criteria, 145 applications were evaluated. Most of the apps belonged to the categories of e-books, e-magazines, herbal product shopping apps, coaching apps, home remedies and teleconsultation. The mean overall MARS score was 2.82 ± 0.69, while the app-specific value was 1.60 ± 0.63. Five apps scored >4.0. Functionality achieved the highest rating (3.90 ± 0.57), followed by engagement (2.68 ± 0.75), aesthetics (2.60 ± 1.08), information (2.09 ± 0.54), and subjective quality (1.92 ± 0.62). Inter-rater reliability was high with Cronbach’s alpha at 0.935(95% C.I.). No significant correlation was observed between MARS scores, user ratings, and downloads (p > 0.05).</div></div><div><h3>Conclusion</h3><div>The current landscape of ayurveda mobile applications lacks adherence to evidence-based content and usability, highlighting the need for collaborative, regulated development.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"82 ","pages":"Article 102606"},"PeriodicalIF":1.7,"publicationDate":"2026-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146024082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-02DOI: 10.1016/j.eujim.2025.102607
Dilara Özturk , Gülcan Bahcecioglu Turan
Introduction
Yoga may support symptom management in individuals with Multiple Sclerosis (MS) by improving sleep, reducing fatigue, and promoting physical activity. This study examined the effects of a six-week yoga program on sleep quality, fatigue, and physical activity levels in patients with MS.
Methods
This randomized controlled trial included 60 patients with MS (30 intervention, 30 control). The intervention group completed 12 yoga sessions over six weeks, while the control group received no intervention. Sleep quality, fatigue, and physical activity were assessed using the Pittsburgh sleep quality index (PSQI), Fatigue severity scale (FSS), and international physical activity questionnaire–short form (IPAQ-SF).
Results
Compared with the control group, the intervention group showed substantial improvements in sleep quality (mean difference −6.14, 95% CI −7.79 to −4.49). Fatigue severity was lower in the yoga group after the intervention (mean difference −1.48, 95% CI −2.44 to −0.52). Physical activity levels increased markedly in the intervention group (mean difference +1857.92 met-min/week, 95% CI 1355.7 to 2360.1). No adverse effects related to the yoga intervention were reported.
Conclusion
A six-week yoga program improved sleep quality, reduced fatigue, and significantly increased physical activity levels in individuals with MS. Yoga may be considered a beneficial complementary approach in the care and symptom management of patients with MS.
{"title":"Effects of yoga on sleep quality, fatigue and physical activity levels in patients with multiple sclerosis: A randomized controlled trial","authors":"Dilara Özturk , Gülcan Bahcecioglu Turan","doi":"10.1016/j.eujim.2025.102607","DOIUrl":"10.1016/j.eujim.2025.102607","url":null,"abstract":"<div><h3>Introduction</h3><div>Yoga may support symptom management in individuals with Multiple Sclerosis (MS) by improving sleep, reducing fatigue, and promoting physical activity. This study examined the effects of a six-week yoga program on sleep quality, fatigue, and physical activity levels in patients with MS.</div></div><div><h3>Methods</h3><div>This randomized controlled trial included 60 patients with MS (30 intervention, 30 control). The intervention group completed 12 yoga sessions over six weeks, while the control group received no intervention. Sleep quality, fatigue, and physical activity were assessed using the Pittsburgh sleep quality index (PSQI), Fatigue severity scale (FSS), and international physical activity questionnaire–short form (IPAQ-SF).</div></div><div><h3>Results</h3><div>Compared with the control group, the intervention group showed substantial improvements in sleep quality (mean difference −6.14, 95% CI −7.79 to −4.49). Fatigue severity was lower in the yoga group after the intervention (mean difference −1.48, 95% CI −2.44 to −0.52). Physical activity levels increased markedly in the intervention group (mean difference +1857.92 met-min/week, 95% CI 1355.7 to 2360.1). No adverse effects related to the yoga intervention were reported.</div></div><div><h3>Conclusion</h3><div>A six-week yoga program improved sleep quality, reduced fatigue, and significantly increased physical activity levels in individuals with MS. Yoga may be considered a beneficial complementary approach in the care and symptom management of patients with MS.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"82 ","pages":"Article 102607"},"PeriodicalIF":1.7,"publicationDate":"2026-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145908827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Antenatal yoga (AY) promotes physical and mental well-being during pregnancy, yet evidence on AY knowledge, attitudes, practices, and barriers in Bangladesh is limited. Understanding these factors is essential for improving AY uptake in low-resource settings. This study investigated the knowledge, attitudes, practices, and barriers related to AY among pregnant women in Bangladesh and examined the influence of socio-demographic factors.
Methods
A cross-sectional survey was conducted among 502 pregnant women across Bangladesh using a standardized semi-structured questionnaire. Descriptive statistics, Chi-square tests, and multivariate logistic regression were performed. A multiple linear regression analysis was also conducted to identify predictors of overall AY knowledge.
Results
Awareness of AY was low (32.5 %), attitudes were moderately positive (32.9 %), and actual practice was very limited (4.6 %). The internet was the primary information source (32.7 %), and lack of information was the most commonly reported barrier (78.4 %). Education was strongly associated with adequate knowledge (OR = 2.10, 95 % CI [1.45, 3.05], p < .001), and women who believed that AY reduces gestational diabetes mellitus (GDM) had higher knowledge (OR = 3.84, 95 % CI [2.60, 5.65], p < .001). Multiple linear regression showed that education, belief in AY’s metabolic benefits, type of family, lack of information, and lack of time significantly predicted AY knowledge (p < .001).
Conclusions
AY knowledge and practice remain low among pregnant Bangladeshi women despite positive attitudes. Convenience sampling and self-reported data limit generalizability. Limited information, lack of guidance, and minimal access to trained instructors restrict AY uptake. Strengthening AY education, integrating guidance into antenatal care, and providing culturally appropriate online and offline resources may enhance adoption and improve maternal health outcomes.
产前瑜伽（AY）促进怀孕期间的身心健康，但孟加拉国关于AY的知识、态度、做法和障碍的证据有限。了解这些因素对于提高低资源环境中AY的吸收至关重要。本研究调查了孟加拉国孕妇中与AY相关的知识、态度、做法和障碍，并检查了社会人口因素的影响。方法采用标准化半结构化问卷对孟加拉国502名孕妇进行横断面调查。进行描述性统计、卡方检验和多元逻辑回归。还进行了多元线性回归分析，以确定总体AY知识的预测因子。结果对急性脑损伤的认知度较低（32.5%），态度一般积极（32.9%），实际操作非常有限（4.6%）。互联网是主要的信息来源（32.7%），缺乏信息是最常见的障碍（78.4%）。受教育程度与充分的知识有很强的相关性（OR = 2.10, 95% CI [1.45, 3.05], p < 001），认为AY能降低妊娠期糖尿病（GDM）的妇女知识水平较高（OR = 3.84, 95% CI [2.60, 5.65], p < 001）。多元线性回归显示，教育程度、对AY代谢益处的信念、家庭类型、信息缺乏和时间缺乏显著预测AY知识（p < .001）。结论尽管孟加拉国孕妇对艾滋病的态度积极，但对艾滋病的认识和实践水平仍然较低。方便的抽样和自我报告的数据限制了推广。有限的信息，缺乏指导，很少有机会获得训练有素的指导员限制了AY的吸收。加强AY教育，将指导纳入产前保健，并提供文化上适当的线上和线下资源，可促进收养并改善孕产妇保健结果。
{"title":"Antenatal yoga in Bangladesh: Pregnant women’s knowledge, attitudes, practices, and barriers to practice","authors":"Farhana Sultana Karim , Satyapriya Maharana , Sayeba Akhter , Shahin Rahman Chowdhury , Mangesh Pandey , Rithika Keshav","doi":"10.1016/j.eujim.2025.102602","DOIUrl":"10.1016/j.eujim.2025.102602","url":null,"abstract":"<div><h3>Introduction</h3><div>Antenatal yoga (AY) promotes physical and mental well-being during pregnancy, yet evidence on AY knowledge, attitudes, practices, and barriers in Bangladesh is limited. Understanding these factors is essential for improving AY uptake in low-resource settings. This study investigated the knowledge, attitudes, practices, and barriers related to AY among pregnant women in Bangladesh and examined the influence of socio-demographic factors.</div></div><div><h3>Methods</h3><div>A cross-sectional survey was conducted among 502 pregnant women across Bangladesh using a standardized semi-structured questionnaire. Descriptive statistics, Chi-square tests, and multivariate logistic regression were performed. A multiple linear regression analysis was also conducted to identify predictors of overall AY knowledge.</div></div><div><h3>Results</h3><div>Awareness of AY was low (32.5 %), attitudes were moderately positive (32.9 %), and actual practice was very limited (4.6 %). The internet was the primary information source (32.7 %), and lack of information was the most commonly reported barrier (78.4 %). Education was strongly associated with adequate knowledge (OR = 2.10, 95 % CI [1.45, 3.05], <em>p</em> < .001), and women who believed that AY reduces gestational diabetes mellitus (GDM) had higher knowledge (OR = 3.84, 95 % CI [2.60, 5.65], <em>p</em> < .001). Multiple linear regression showed that education, belief in AY’s metabolic benefits, type of family, lack of information, and lack of time significantly predicted AY knowledge (<em>p</em> < .001).</div></div><div><h3>Conclusions</h3><div>AY knowledge and practice remain low among pregnant Bangladeshi women despite positive attitudes. Convenience sampling and self-reported data limit generalizability. Limited information, lack of guidance, and minimal access to trained instructors restrict AY uptake. Strengthening AY education, integrating guidance into antenatal care, and providing culturally appropriate online and offline resources may enhance adoption and improve maternal health outcomes.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"81 ","pages":"Article 102602"},"PeriodicalIF":1.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145920935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Helianthus tuberosus, commonly known as Jerusalem artichoke, has been recognized for its diverse medicinal applications attributed to its rich composition of bioactive compounds. Despite the growing body of research, a comprehensive understanding of the publication landscape concerning its medicinal potential remains limited. This study aims to perform a detailed bibliometric analysis of the literature pertaining to the medicinal applications of H. tuberosus, elucidating publication characteristics, journal dissemination patterns, author and institutional productivity, country-specific research contributions, and prevalent thematic focuses.
Methods
A systematic search was conducted from January 1979 to February 2025 using the Web of Science and Scopus databases. The search strategy involved querying article titles, abstracts, and keywords with relevant terms related to H. tuberosus and its medicinal applications. No restrictions were placed on publication year, but only English-language articles were included. After removing duplicates and normalizing metadata, a refined dataset of 129 unique documents were analyzed. Bibliometric analysis was performed using the 'bibliometrix' package within the RStudio environment.
Results
The analysis encompassed 129 research articles, featuring 568 authors from 40 countries, covering a 45-year period. The annual progression of literature showed variability over time, with author activity peaking in 2021 and 2022, each year producing 18 and 16 publications, respectively. The top ten journals contributed to 25 publications, accounting for 16.4% of the total output, with "Veterinary World" leading at four publications. Among the authors, Bochnia M, Glatter M, Greef J, Grela E, Ilgaza A, Jogloy S, and Zeyner A were prominent, each contributing five articles. Chulalongkorn University in Thailand was the most prolific institution, contributing 16 studies. Thailand led in publication count with 44 articles and the most cited country was Turkey with 449 citations. Keyword analysis revealed "Jerusalem artichoke," "inulin," and "Helianthus tuberosus" as the most frequently occurring terms.
Conclusion
This bibliometric analysis provides a comprehensive overview of the research landscape concerning the medicinal potential of H. tuberosus. The findings highlight key contributors, prevalent research themes, and collaborative networks, offering valuable insights for future research directions and potential therapeutic applications of this versatile plant.
菊芋（helianthus tuberosus），俗称耶路撒冷洋蓟（Jerusalem artichoke），因其丰富的生物活性成分而被公认为具有多种药用价值。尽管有越来越多的研究，但对其医学潜力的出版景观的全面理解仍然有限。本研究旨在对有关结核分枝杆菌医学应用的文献进行详细的文献计量学分析，阐明其出版特征、期刊传播模式、作者和机构生产力、特定国家的研究贡献和流行的专题重点。方法系统检索1979年1月~ 2025年2月的Web of Science和Scopus数据库。搜索策略包括查询文章标题、摘要和关键词，其中包含与结核分枝杆菌及其医学应用相关的术语。对出版年份没有限制，但只包括英文文章。在删除重复项并规范化元数据之后，分析了包含129个唯一文档的精细化数据集。使用RStudio环境中的“bibliometrix”包执行文献计量分析。该分析包括来自40个国家的568位作者的129篇研究论文，涵盖了45年的时间。文献的年度进展表现出随时间的变化，作者活动在2021年和2022年达到顶峰，每年分别发表18篇和16篇论文。排名前十的期刊共发表论文25篇，占总产出的16.4%，其中《兽医世界》（Veterinary World）发表论文4篇。在作者中，Bochnia M, Glatter M, Greef J, Grela E, Ilgaza A， Jogloy S和Zeyner A是杰出的，每人贡献了5篇文章。泰国的朱拉隆功大学是最多产的机构，贡献了16项研究。泰国发表了44篇文章，排名第一，被引用次数最多的国家是土耳其，有449次被引用。关键词分析显示，“菊芋”、“菊粉”和“向日葵”是出现频率最高的词。结论本文献计量学分析提供了一个全面的研究概况，关于结核分枝杆菌的药用潜力。这些发现突出了主要贡献者、流行的研究主题和合作网络，为这种多功能植物的未来研究方向和潜在的治疗应用提供了有价值的见解。
{"title":"Unveiling the medicinal potential of Helianthus tuberosus: A comprehensive bibliometric study","authors":"Ramazon Safarzoda Sharoffidin , Jabor Yusufi Salomiddin , Shahriyor Bakhtiyor Sharifzoda , Khushronsho Abdukarimzoda , Afshin Zare , Nadiar M. Mussin , Kulyash R. Zhilisbayeva , Nader Tanideh , Amin Tamadon","doi":"10.1016/j.eujim.2025.102608","DOIUrl":"10.1016/j.eujim.2025.102608","url":null,"abstract":"<div><h3>Introduction</h3><div><em>Helianthus tuberosus</em>, commonly known as Jerusalem artichoke, has been recognized for its diverse medicinal applications attributed to its rich composition of bioactive compounds. Despite the growing body of research, a comprehensive understanding of the publication landscape concerning its medicinal potential remains limited. This study aims to perform a detailed bibliometric analysis of the literature pertaining to the medicinal applications of <em>H. tuberosus</em>, elucidating publication characteristics, journal dissemination patterns, author and institutional productivity, country-specific research contributions, and prevalent thematic focuses.</div></div><div><h3>Methods</h3><div>A systematic search was conducted from January 1979 to February 2025 using the Web of Science and Scopus databases. The search strategy involved querying article titles, abstracts, and keywords with relevant terms related to <em>H. tuberosus</em> and its medicinal applications. No restrictions were placed on publication year, but only English-language articles were included. After removing duplicates and normalizing metadata, a refined dataset of 129 unique documents were analyzed. Bibliometric analysis was performed using the 'bibliometrix' package within the RStudio environment.</div></div><div><h3>Results</h3><div>The analysis encompassed 129 research articles, featuring 568 authors from 40 countries, covering a 45-year period. The annual progression of literature showed variability over time, with author activity peaking in 2021 and 2022, each year producing 18 and 16 publications, respectively. The top ten journals contributed to 25 publications, accounting for 16.4% of the total output, with \"Veterinary World\" leading at four publications. Among the authors, Bochnia M, Glatter M, Greef J, Grela E, Ilgaza A, Jogloy S, and Zeyner A were prominent, each contributing five articles. Chulalongkorn University in Thailand was the most prolific institution, contributing 16 studies. Thailand led in publication count with 44 articles and the most cited country was Turkey with 449 citations. Keyword analysis revealed \"Jerusalem artichoke,\" \"inulin,\" and \"<em>Helianthus tuberosus</em>\" as the most frequently occurring terms.</div></div><div><h3>Conclusion</h3><div>This bibliometric analysis provides a comprehensive overview of the research landscape concerning the medicinal potential of <em>H. tuberosus</em>. The findings highlight key contributors, prevalent research themes, and collaborative networks, offering valuable insights for future research directions and potential therapeutic applications of this versatile plant.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"82 ","pages":"Article 102608"},"PeriodicalIF":1.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145975267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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