Medicinal plants provide humanity with important phytochemical compounds and extracts which are widely used in treatment of many diseases. Fungal infections are one of these diseases which are widely distributed especially in developing countries; medicinal plants are extensively used in developing countries. There are few antifungal agents, most of them are expensive and have many adverse effects, also there is high incidence of drug resistance among some available antifungal agents, hence for these mentioned reasons many people, especially in developing countries, use medicinal plants (either alone, combined together or combined with known antifungal drugs) in treatment of many fungal infections. This rise a new and important issue about plant(s) – plant(s) and plant(s) - drug interactions. The aim of this review is to try to fill the gap in understanding the interactions of plant(s) - plant(s) and plant(s) – drug(s) combinations by providing an overview of some evidence-based researches done in this field, so our review highlights many interactions between medicinal plants constituents with current available antifungal agents, these interactions may be synergistic, additive, indifferent or antagonistic, so, if there is any antagonistic effect, we recommend to avoid using the combination which caused this effect. We collected a lot of studies which studied the interactions between plant(s) (including extracts, isolated active constituents, essential oils, plants latexes and other phytochemicals) used either together or with conventional antifungal agents. This will not only bring about better understanding of both phytochemicals and antifungal activity, but also may help in searching and developing new safely and effective drugs, specially with those combinations which showed synergistic effect.
{"title":"A Review of Antifungal Activity of Combined Plant Extracts or Plant Exudates from Medicinal Plants either together or with Known Antifungal Agents","authors":"Moh’d Hamid Haji, Asma Balla Mohamed, Alaa Altayeb Albashir, M. Mirghani","doi":"10.9734/ejmp/2022/v33i830483","DOIUrl":"https://doi.org/10.9734/ejmp/2022/v33i830483","url":null,"abstract":"Medicinal plants provide humanity with important phytochemical compounds and extracts which are widely used in treatment of many diseases. Fungal infections are one of these diseases which are widely distributed especially in developing countries; medicinal plants are extensively used in developing countries. There are few antifungal agents, most of them are expensive and have many adverse effects, also there is high incidence of drug resistance among some available antifungal agents, hence for these mentioned reasons many people, especially in developing countries, use medicinal plants (either alone, combined together or combined with known antifungal drugs) in treatment of many fungal infections. This rise a new and important issue about plant(s) – plant(s) and plant(s) - drug interactions. \u0000The aim of this review is to try to fill the gap in understanding the interactions of plant(s) - plant(s) and plant(s) – drug(s) combinations by providing an overview of some evidence-based researches done in this field, so our review highlights many interactions between medicinal plants constituents with current available antifungal agents, these interactions may be synergistic, additive, indifferent or antagonistic, so, if there is any antagonistic effect, we recommend to avoid using the combination which caused this effect. We collected a lot of studies which studied the interactions between plant(s) (including extracts, isolated active constituents, essential oils, plants latexes and other phytochemicals) used either together or with conventional antifungal agents. This will not only bring about better understanding of both phytochemicals and antifungal activity, but also may help in searching and developing new safely and effective drugs, specially with those combinations which showed synergistic effect.","PeriodicalId":11969,"journal":{"name":"European journal of medicinal plants","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82527684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-03DOI: 10.9734/ejmp/2022/v33i830482
T. F. Dos Santos, Emillene de Holanda Colli, D. Benitez, Maria Eugênia de Lima Pinheiro, Barbara dos Reis Dal Lago Rodrigues, Silvio Rodrigo Arevalos Davalos, M. B. Tavares, Celso Dlr Neto, Camila Bs Campos, F. D. Oliveira, Gleyson Murillo Aguilera Moraes, M. R. Goveia, Marco Antônio de Souza Borges Tavares
This is a literature review with the objective of presenting scientific evidence about the therapeutic importance of the use of Anacardium humile for the treatment of infected skin wounds. Retrospective and analytical study carried out from 1999 to 2021, in the Bireme, UpToDate, Pubmed and Scielo databases. The association of the descriptors “Phytotherapy” was used; “Cerrado and Pantanal Plants”; “Wounds contaminated by bacteria”; “elastic fibers”. Of the 248 articles analyzed, 36 were included in the review because they met the inclusion criteria. Among the results, it was evidenced that the conventional treatments, although effective (the gold standard being Sulfadiazine 1% silver), present toxicity to human keratinocytes and fibroblasts, with this, it is concluded that further research will be necessary to prove the effectiveness of new treatment options or association of herbal medicines with treatment.
{"title":"New Therapeutic Perspective Based on Anacardium humile in the Treatment of Skin Wound Infected by Staphylococcus aureus","authors":"T. F. Dos Santos, Emillene de Holanda Colli, D. Benitez, Maria Eugênia de Lima Pinheiro, Barbara dos Reis Dal Lago Rodrigues, Silvio Rodrigo Arevalos Davalos, M. B. Tavares, Celso Dlr Neto, Camila Bs Campos, F. D. Oliveira, Gleyson Murillo Aguilera Moraes, M. R. Goveia, Marco Antônio de Souza Borges Tavares","doi":"10.9734/ejmp/2022/v33i830482","DOIUrl":"https://doi.org/10.9734/ejmp/2022/v33i830482","url":null,"abstract":"This is a literature review with the objective of presenting scientific evidence about the therapeutic importance of the use of Anacardium humile for the treatment of infected skin wounds. Retrospective and analytical study carried out from 1999 to 2021, in the Bireme, UpToDate, Pubmed and Scielo databases. The association of the descriptors “Phytotherapy” was used; “Cerrado and Pantanal Plants”; “Wounds contaminated by bacteria”; “elastic fibers”. Of the 248 articles analyzed, 36 were included in the review because they met the inclusion criteria. Among the results, it was evidenced that the conventional treatments, although effective (the gold standard being Sulfadiazine 1% silver), present toxicity to human keratinocytes and fibroblasts, with this, it is concluded that further research will be necessary to prove the effectiveness of new treatment options or association of herbal medicines with treatment.","PeriodicalId":11969,"journal":{"name":"European journal of medicinal plants","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77634513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-21DOI: 10.9734/ejmp/2022/v33i830481
A. Idi, M. Atiku, A. Alhassan, I. Muhammad
This study was aimed at studying the effect of solvents (n-hexane, chloroform and methanol) fractions of Cucurbita maxima (pumpkin) cuticular lipids on metabolic biomarkers of cardiovascular disease using L-NAME induced hypertensive rats. A total of thirty-six (120-150 g) albino rats were randomly selected and placed into twelve groups of three rats each were used for this study. Each rat was weighed and tagged and thereafter weighed weekly for five weeks of the experiment. Rats were induced with hypertension using 40mg/Kg body weight/24hours. Other rats were placed on normal feeds and water while biomarkers were assayed and recorded on weekly basis. Group I served as normal control, Group II were hypertensive control, Group III were induced with hypertension and administered with standard drug while Groups IV-XII were induced with hypertension and administered with varying doses of n-hexane, chloroform and methanol fractions. A slight alteration on metabolic biomarkers between the normal control group and hypertensive control group was recorded, which was reversed by the administration of methanol fraction. Thus, cuticular lipids from Cucurbita maxima might have some anti-hypertensive potentials.
{"title":"Effect of Solvents Fractions of Cucurbita maxima Cuticular Lipids on Metabolic Biomarkers of Cardiovascular Disease","authors":"A. Idi, M. Atiku, A. Alhassan, I. Muhammad","doi":"10.9734/ejmp/2022/v33i830481","DOIUrl":"https://doi.org/10.9734/ejmp/2022/v33i830481","url":null,"abstract":"This study was aimed at studying the effect of solvents (n-hexane, chloroform and methanol) fractions of Cucurbita maxima (pumpkin) cuticular lipids on metabolic biomarkers of cardiovascular disease using L-NAME induced hypertensive rats. A total of thirty-six (120-150 g) albino rats were randomly selected and placed into twelve groups of three rats each were used for this study. Each rat was weighed and tagged and thereafter weighed weekly for five weeks of the experiment. Rats were induced with hypertension using 40mg/Kg body weight/24hours. Other rats were placed on normal feeds and water while biomarkers were assayed and recorded on weekly basis. Group I served as normal control, Group II were hypertensive control, Group III were induced with hypertension and administered with standard drug while Groups IV-XII were induced with hypertension and administered with varying doses of n-hexane, chloroform and methanol fractions. A slight alteration on metabolic biomarkers between the normal control group and hypertensive control group was recorded, which was reversed by the administration of methanol fraction. Thus, cuticular lipids from Cucurbita maxima might have some anti-hypertensive potentials.","PeriodicalId":11969,"journal":{"name":"European journal of medicinal plants","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80549130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-08DOI: 10.9734/ejmp/2022/v33i730479
V. Jha, F. Shaikh, Nikita Tendulkar, Siddharth Pandya, Bhakti Madaye, Esha Gupta, F. Khan, Navdeep Kaur, T. Jain, Stanford Almeida, P. Mane
The study investigates the therapeutic potential of the Citrus aurantium var. amara essential oil extracted from the blossoms of the bitter orange plant by examining its chemical composition, thermal stability, and potency against infectious disease-causing pathogens. Initially, the volatile components of the essential oil were evaluated by obtaining a chromatographic fingerprint using HPTLC and FTIR spectrum identification. Furthermore, a thermal profile of the essential oil was obtained using the thermogravimetric-differential thermal analysis and differential scanning calorimetric analysis. A predetermined set of antibiotic-resistant microorganisms were used to examine the antibacterial activity of the essential oil. Lastly, its anti-inflammatory activity was assessed using the albumin denaturation assay. The research concluded that the Citrus aurantium var. Amara essential oil exhibits potential therapeutic characteristics which can be further explored through in vivo studies.
该研究通过考察其化学成分、热稳定性和对传染性病原体的效力，研究了从苦橙植物的花朵中提取的柑橘aurantium var. amara精油的治疗潜力。首先，通过HPTLC和FTIR光谱识别获得挥发油的色谱指纹图谱来评估挥发油的挥发性成分。利用热重-差示热分析和差示扫描量热分析得到了精油的热谱图。一组预先确定的耐药微生物被用来检查精油的抗菌活性。最后，用白蛋白变性试验评估其抗炎活性。本研究认为，柑橘精油具有潜在的治疗作用，可通过体内实验进一步探索。
{"title":"Evaluation of Physiochemical Properties, Thermal Behavior and Phytopharmaceutical Potential of Citrus aurantium’s Essential Oil","authors":"V. Jha, F. Shaikh, Nikita Tendulkar, Siddharth Pandya, Bhakti Madaye, Esha Gupta, F. Khan, Navdeep Kaur, T. Jain, Stanford Almeida, P. Mane","doi":"10.9734/ejmp/2022/v33i730479","DOIUrl":"https://doi.org/10.9734/ejmp/2022/v33i730479","url":null,"abstract":"The study investigates the therapeutic potential of the Citrus aurantium var. amara essential oil extracted from the blossoms of the bitter orange plant by examining its chemical composition, thermal stability, and potency against infectious disease-causing pathogens. Initially, the volatile components of the essential oil were evaluated by obtaining a chromatographic fingerprint using HPTLC and FTIR spectrum identification. Furthermore, a thermal profile of the essential oil was obtained using the thermogravimetric-differential thermal analysis and differential scanning calorimetric analysis. A predetermined set of antibiotic-resistant microorganisms were used to examine the antibacterial activity of the essential oil. Lastly, its anti-inflammatory activity was assessed using the albumin denaturation assay. The research concluded that the Citrus aurantium var. Amara essential oil exhibits potential therapeutic characteristics which can be further explored through in vivo studies.","PeriodicalId":11969,"journal":{"name":"European journal of medicinal plants","volume":"96 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80522248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-08DOI: 10.9734/ejmp/2022/v33i730480
Glauciemar Del-Vechio Vieira, Julianna Oliveira de Lucas Xavier, A. L. S. M. Araújo, J. Conegundes, E. S. Fontes, O. Sousa
Aims: In this study, chemical constituents and biological activities of the Annona muricata L. fruit peels were evaluated using methanol extract (MEAM) and hexane (HFAM), dichloromethane (DFAM), ethyl acetate (EFAM), and butanol (BFAM) fractions. Place and Duration of Study: All the experiments were done in the Department of Pharmaceutical Sciences and Department of Biochemistry, Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, 36026-900, Brazil, between January 2012 and July 2016. Methodology: Phytochemical screening (specific chemical reactions), total phenolic and flavonoid contents (Spectrophotometric methods) and chemical compounds were assessed (High performance liquid chromatography analysis). The antioxidant activity was determined by 2,2-diphenyl-1-picrylhydrazyl (DPPH), ferric reducing antioxidant power (FRAP), beta-carotene, and thiobarbituric acid assays. The inhibitory effect against digestive enzymes (lipase, α-amylase and α-glucosidase) was measured by spectrophotometric assays and and toxicity by the brine shrimp lethality bioassay. Results: Tannins, flavonoids, coumarins, terpenes and steroids, saponins, and alkaloids were detected. EFAM had the highest values of total phenolic and flavonoids, while a similar compound to annonacin was found in MEAM by HPLC. EFAM was also more active in DPPH and FRAP assays, and HFAM was effective in inhibiting the linoleic acid oxidation and the malondialdehyde. MEAM and fractions blocked lipase, α-amylase and α-glucosidase, while HFAM and DFAM were toxic against Artemia salina. Conclusion: The results showed that the A. muricata fruit peels have important biological effects, which can bring great benefits to human and animal health.
目的:采用甲醇提取物(MEAM)和己烷(hfm)、二氯甲烷(DFAM)、乙酸乙酯(EFAM)、丁醇(BFAM)等组分对番麻果皮的化学成分和生物活性进行了研究。研究地点和时间:所有实验均于2012年1月至2016年7月在巴西米纳斯吉拉斯州Juiz de Fora联邦大学药学系和生物化学系完成，地址:36026-900。方法:植物化学筛选(特定化学反应)，总酚和类黄酮含量(分光光度法)和化学成分(高效液相色谱法)进行评估。采用2,2-二苯基-1-苦味酰肼(DPPH)、铁还原抗氧化能力(FRAP)、β -胡萝卜素和硫代巴比妥酸测定其抗氧化活性。用分光光度法测定其对脂肪酶、α-淀粉酶和α-葡萄糖苷酶的抑制作用，用盐水对虾致死生物试验测定其毒性。结果:检出单宁、黄酮类、香豆素、萜烯及甾体、皂苷、生物碱。EFAM中总酚和黄酮类化合物含量最高，而MEAM中含有与茶酸相似的化合物。在DPPH和FRAP实验中，EFAM也更有活性，并且对亚油酸氧化和丙二醛有抑制作用。MEAM及其组分阻断脂肪酶、α-淀粉酶和α-葡萄糖苷酶，而HFAM和DFAM对青蒿有毒性作用。结论:结果表明，村田果皮具有重要的生物学效应，对人类和动物健康都有很大的益处。
{"title":"Soursop (Annona muricata L.) Fruit Peels as Source of Phenolic Constituents and Annonacin with Biological Activities","authors":"Glauciemar Del-Vechio Vieira, Julianna Oliveira de Lucas Xavier, A. L. S. M. Araújo, J. Conegundes, E. S. Fontes, O. Sousa","doi":"10.9734/ejmp/2022/v33i730480","DOIUrl":"https://doi.org/10.9734/ejmp/2022/v33i730480","url":null,"abstract":"Aims: In this study, chemical constituents and biological activities of the Annona muricata L. fruit peels were evaluated using methanol extract (MEAM) and hexane (HFAM), dichloromethane (DFAM), ethyl acetate (EFAM), and butanol (BFAM) fractions. \u0000Place and Duration of Study: All the experiments were done in the Department of Pharmaceutical Sciences and Department of Biochemistry, Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, 36026-900, Brazil, between January 2012 and July 2016. \u0000Methodology: Phytochemical screening (specific chemical reactions), total phenolic and flavonoid contents (Spectrophotometric methods) and chemical compounds were assessed (High performance liquid chromatography analysis). The antioxidant activity was determined by 2,2-diphenyl-1-picrylhydrazyl (DPPH), ferric reducing antioxidant power (FRAP), beta-carotene, and thiobarbituric acid assays. The inhibitory effect against digestive enzymes (lipase, α-amylase and α-glucosidase) was measured by spectrophotometric assays and and toxicity by the brine shrimp lethality bioassay. \u0000Results: Tannins, flavonoids, coumarins, terpenes and steroids, saponins, and alkaloids were detected. EFAM had the highest values of total phenolic and flavonoids, while a similar compound to annonacin was found in MEAM by HPLC. EFAM was also more active in DPPH and FRAP assays, and HFAM was effective in inhibiting the linoleic acid oxidation and the malondialdehyde. MEAM and fractions blocked lipase, α-amylase and α-glucosidase, while HFAM and DFAM were toxic against Artemia salina. \u0000Conclusion: The results showed that the A. muricata fruit peels have important biological effects, which can bring great benefits to human and animal health.","PeriodicalId":11969,"journal":{"name":"European journal of medicinal plants","volume":"27 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72621644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-20DOI: 10.9734/ejmp/2022/v33i730478
P. S. Babu, D. Bhavya, E. S. Murthy, B. Ramesha, M. P. S. Pujji, Achala Mogra, I. Chandrika, S. N. Kumar
To evaluate phytochemical, heavy metal, pesticide, microbial assay, and also FTIR studies of Angiatico-2 (A-2) an Electrohomeopathic remedy to evaluate safety and efficacy for its usage. Electrohomeopathy / Electropathy is one purely herbal medical system invented by Italian C. C. Mattie (1809-1896) has been practiced since the 1860s across the world. Electrohomeopathy has its own unique principles, plants selection, the process of remedies preparation, diagnosis, selection, and combination of drugs for different diseases, dosage, and treatment methods. In India, it is estimated that there are about 450-500 institutions imparting education and research, about 4.5 to 5 lacks practitioners are practicing and millions of population getting benefits currently. The government of India initiated steps to recognize Electrohomeopathy medical system under the constitution. Unfortunately, there is very limited scientific evidence to evaluate the safety, efficacy, phytochemical, and pharmacology studies in Electrohomeopathy. We prepared Angiatico-2 an Electrohomeopathic remedy as Mother Solution and D4 dilutions and evaluated it’s phytochemical screening, TLC, FTIR spectrum, Physical and Chemical nature, presence or absence of heavy metals, Pesticide, Food Additives and Microbial under NABL standards for its safety usage. Electrohomeopathic herbal remedy Angiatico-2 prepared by using 7 non poisonous plants by Krauss method under standard condition and not shown any heavy metals, pesticide presence and also no microbial presence above the limit level of FSSAI standard. Present studies of Electrohomeopathic herbal remedy Angiatico-2 preparation and its screening in standard scientific laboratory condition, TLC & FTIR studies may become reference standards for the manufacture of Angiatico-2 for bulk quantity at industrial level for. The present research investigations outcome with reproducibility may become standard markers or signatures to assess the quality and safe use of Angiatico-2.
评估电顺势疗法药物Angiatico-2 (A-2)的植物化学、重金属、农药、微生物测定和FTIR研究，以评估其使用的安全性和有效性。电顺势疗法是由意大利人C. C. Mattie(1809-1896)发明的一种纯草药医疗系统，自19世纪60年代以来一直在世界各地实践。电顺势疗法有自己独特的原理、植物选择、药物制备过程、诊断、选择和药物组合，针对不同的疾病、剂量和治疗方法。在印度，据估计大约有450-500个教育和研究机构，大约4.5 -5个缺乏从业人员，目前有数百万人口受益。印度政府在宪法下启动了承认电顺势疗法医疗体系的步骤。不幸的是，评估电顺势疗法的安全性、有效性、植物化学和药理学研究的科学证据非常有限。制备了电顺势疗法药物Angiatico-2作为母液和D4稀释剂，并在NABL标准下对其植物化学筛选、TLC、FTIR光谱、理化性质、重金属、农药、食品添加剂和微生物的存在和不存在进行了评价。电顺势疗法草药angatico -2，选用7种无毒植物，在标准条件下采用Krauss法制备，无重金属、农药、微生物含量超过FSSAI标准限值。目前对电顺势疗法中草药angatico -2的制备及其在标准科学实验室条件下的筛选、TLC和FTIR研究可作为大批量生产angatico -2的参考标准。本研究结果具有可重复性，可作为评价angatico -2的质量和安全性的标准标志或标志。
{"title":"Preparation of Angiotico-2 (A-2) an Electrohomeopathic Remedy, its TLC, FTIR, Pharmacognocalogical, Phytochemical, Chemical, Heavy Metal, Pesticide, Food Additives and Microbial Screening for Safe Usage","authors":"P. S. Babu, D. Bhavya, E. S. Murthy, B. Ramesha, M. P. S. Pujji, Achala Mogra, I. Chandrika, S. N. Kumar","doi":"10.9734/ejmp/2022/v33i730478","DOIUrl":"https://doi.org/10.9734/ejmp/2022/v33i730478","url":null,"abstract":"To evaluate phytochemical, heavy metal, pesticide, microbial assay, and also FTIR studies of Angiatico-2 (A-2) an Electrohomeopathic remedy to evaluate safety and efficacy for its usage. Electrohomeopathy / Electropathy is one purely herbal medical system invented by Italian C. C. Mattie (1809-1896) has been practiced since the 1860s across the world. Electrohomeopathy has its own unique principles, plants selection, the process of remedies preparation, diagnosis, selection, and combination of drugs for different diseases, dosage, and treatment methods. In India, it is estimated that there are about 450-500 institutions imparting education and research, about 4.5 to 5 lacks practitioners are practicing and millions of population getting benefits currently. The government of India initiated steps to recognize Electrohomeopathy medical system under the constitution. Unfortunately, there is very limited scientific evidence to evaluate the safety, efficacy, phytochemical, and pharmacology studies in Electrohomeopathy. We prepared Angiatico-2 an Electrohomeopathic remedy as Mother Solution and D4 dilutions and evaluated it’s phytochemical screening, TLC, FTIR spectrum, Physical and Chemical nature, presence or absence of heavy metals, Pesticide, Food Additives and Microbial under NABL standards for its safety usage. Electrohomeopathic herbal remedy Angiatico-2 prepared by using 7 non poisonous plants by Krauss method under standard condition and not shown any heavy metals, pesticide presence and also no microbial presence above the limit level of FSSAI standard. Present studies of Electrohomeopathic herbal remedy Angiatico-2 preparation and its screening in standard scientific laboratory condition, TLC & FTIR studies may become reference standards for the manufacture of Angiatico-2 for bulk quantity at industrial level for. The present research investigations outcome with reproducibility may become standard markers or signatures to assess the quality and safe use of Angiatico-2.","PeriodicalId":11969,"journal":{"name":"European journal of medicinal plants","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84871475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-04DOI: 10.9734/ejmp/2022/v33i730477
J. Ledezma, J. Vázquez, E. O. Hernández, L. O. A. Rembao, J. A. P. Islas, E. García, Y. J. G. Cruz
This research is based on the effect of the lemon tea concentrate whose polyphenols are powerful antioxidants. Studies have shown that they suppress free radicals in a more effective way than vitamins C or E; in some of cases, specifically in H. pylori, which generally colonizes the human stomach as a single strain with stable characteristics. Authors mention that this colonization can be stable throughout life. This bacterium is related to chronic gastritis, and although H. pylori infection is still the main cause of duodenal and gastric ulcers, the prevalence of ulcers associated with H. pylori is decreasing, while that of related ulcers with non-steroidal anti-inflammatory drugs (NSAIDs) is increasing. Much of what has been published lately about H. pylori and has focused on its important changes in the pattern of the disease and in the potential value of eradication therapy.
{"title":"Effect of Lemon Oil Concentrate Cymbopogon citratus ERILIM® towards the Helicobacter pylori Bacteria: A Case Report","authors":"J. Ledezma, J. Vázquez, E. O. Hernández, L. O. A. Rembao, J. A. P. Islas, E. García, Y. J. G. Cruz","doi":"10.9734/ejmp/2022/v33i730477","DOIUrl":"https://doi.org/10.9734/ejmp/2022/v33i730477","url":null,"abstract":"This research is based on the effect of the lemon tea concentrate whose polyphenols are powerful antioxidants. Studies have shown that they suppress free radicals in a more effective way than vitamins C or E; in some of cases, specifically in H. pylori, which generally colonizes the human stomach as a single strain with stable characteristics. Authors mention that this colonization can be stable throughout life. This bacterium is related to chronic gastritis, and although H. pylori infection is still the main cause of duodenal and gastric ulcers, the prevalence of ulcers associated with H. pylori is decreasing, while that of related ulcers with non-steroidal anti-inflammatory drugs (NSAIDs) is increasing. Much of what has been published lately about H. pylori and has focused on its important changes in the pattern of the disease and in the potential value of eradication therapy.","PeriodicalId":11969,"journal":{"name":"European journal of medicinal plants","volume":"85 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90802311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-30DOI: 10.9734/ejmp/2022/v33i730475
Vaskar Das, Vijeta Rai, N. Jaishee, Shilpi Ghosh
Background of the Study: Thuja orientalis L. is an indigenous medicinal plant belonging to family Cupressaceae found in Darjeeling Himalayan region, Dooars and Tarai region of India. The plant cone has been used traditionally as medicine to treat various diseases, like bronchitis, bacterial skin infection, osteoarthritis, trigeminal neuralgia. Aim: The aim of the present study is to evaluate the plant cone for phytochemical constinuents, and in vitro antioxidant, and antimicrobial properties. Place and Duration of Study: All the experiments were done in the Department of Biotechnology, University of North Bengal, Darjeeling, West Bengal, 734013, India. Methodology: Methanolic extract of T. orientalis cone was analyzed for phytochemicals by various biochemical methods. Antioxidant properties were analyzed by in vitro assays of DPPH, ABTS, NO and H2O2 scavenging. Antibacterial property was analyzed by agar well diffusion method and antifungal assay was monitored by radial growth bioassay. Results: Methanolic extract of T. orientalis cone contained flavonoid, phenol, saponin, tannin, terpenoid and alkaloid. The extract showed significant in-vitro antioxidant and antimicrobial activity. Conclusions: The study revealed that T. orientalis cone has potential as source of antioxidant, antibacterial and antifungal agents. Our further study is directed towards the isolation, and characterization of active compound from methanolic extract and evaluation of its potentiality against high blood sugar.
研究背景:东方柏科(Thuja orientalis L.)是一种产于印度大吉岭喜马拉雅地区、Dooars和Tarai地区的本土药用植物。传统上，这种植物的球果被用作治疗各种疾病的药物，如支气管炎、细菌性皮肤感染、骨关节炎、三叉神经痛。目的:评价植物球果的化学成分及其体外抗氧化、抗菌性能。研究地点和时间:所有实验在北孟加拉大学生物技术系完成，大吉岭，西孟加拉邦，734013，印度。方法:采用多种生化方法对东方桦醇提物进行化学成分分析。通过体外DPPH、ABTS、NO和H2O2清除实验分析其抗氧化性能。采用琼脂孔扩散法测定其抑菌性能，采用径向生长法测定其抑菌活性。结果:东方红醇提物中含有黄酮类、酚类、皂苷类、单宁类、萜类和生物碱。提取物具有显著的体外抗氧化和抗菌活性。结论:本研究揭示了东方蓟作为抗氧化、抗菌和抗真菌药物的潜在来源。我们下一步的研究方向是从甲醇提取物中分离、鉴定活性化合物，并评价其抗高血糖的潜力。
{"title":"Phytochemical, Antioxidant, Antibacterial and Antifungal Investigations of Thuja orientalis Cone","authors":"Vaskar Das, Vijeta Rai, N. Jaishee, Shilpi Ghosh","doi":"10.9734/ejmp/2022/v33i730475","DOIUrl":"https://doi.org/10.9734/ejmp/2022/v33i730475","url":null,"abstract":"Background of the Study: Thuja orientalis L. is an indigenous medicinal plant belonging to family Cupressaceae found in Darjeeling Himalayan region, Dooars and Tarai region of India. The plant cone has been used traditionally as medicine to treat various diseases, like bronchitis, bacterial skin infection, osteoarthritis, trigeminal neuralgia. \u0000Aim: The aim of the present study is to evaluate the plant cone for phytochemical constinuents, and in vitro antioxidant, and antimicrobial properties. \u0000Place and Duration of Study: All the experiments were done in the Department of Biotechnology, University of North Bengal, Darjeeling, West Bengal, 734013, India. \u0000Methodology: Methanolic extract of T. orientalis cone was analyzed for phytochemicals by various biochemical methods. Antioxidant properties were analyzed by in vitro assays of DPPH, ABTS, NO and H2O2 scavenging. Antibacterial property was analyzed by agar well diffusion method and antifungal assay was monitored by radial growth bioassay. \u0000Results: Methanolic extract of T. orientalis cone contained flavonoid, phenol, saponin, tannin, terpenoid and alkaloid. The extract showed significant in-vitro antioxidant and antimicrobial activity. \u0000Conclusions: The study revealed that T. orientalis cone has potential as source of antioxidant, antibacterial and antifungal agents. Our further study is directed towards the isolation, and characterization of active compound from methanolic extract and evaluation of its potentiality against high blood sugar.","PeriodicalId":11969,"journal":{"name":"European journal of medicinal plants","volume":"75 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80655071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-28DOI: 10.9734/ejmp/2022/v33i630472
Alain S-P. Kabasele Kalombo, F. Mukeba, Assumani Zabo Idrissa, J. Divengi, P. Mbuyi, J. Kayembe, D. N'Da
Senna occidentalis L. has been used in several traditional medicines against various diseases and this is based on its botanical, ethnopharmacology, and phytochemistry profiles. This powerful herb is recognized for its antibacterial, antifungal, antidiabetic, anticancer, antimutagenic, protective, and inflammatory hepatic activity. Multiple chemical compounds, including achrosine, aloe-emodin, emodin, anthraquinones, etc., have been isolated from this plant. The results of this bibliographic research thus presented in this review have demonstrated the ability of certain extracts from S. occidentalis L. to lower the lipid peroxide content, the activity of gamma-glutamyl transpeptidase and phospholipase A2 in exudates of the granuloma of cotton pellets, thus resulting in a reduced availability of arachidonic acid, an important precursor in the biosynthesis of prostaglandins, which are the only likely source and/or cause of dysmenorrhea. Thus, based on its phytochemical profile and its pharmacological properties, it is therefore suggested that S. occidentalis would be a potential and effective remedy in the treatment of dysmenorrhea.
{"title":"Review on the Ethnobotany, Phytochemical and Pharmacological Profile of Senna occidentalis L. (Fabaceae): Potential Application as Remedy in the Treatment of Dysmenorrhea","authors":"Alain S-P. Kabasele Kalombo, F. Mukeba, Assumani Zabo Idrissa, J. Divengi, P. Mbuyi, J. Kayembe, D. N'Da","doi":"10.9734/ejmp/2022/v33i630472","DOIUrl":"https://doi.org/10.9734/ejmp/2022/v33i630472","url":null,"abstract":"Senna occidentalis L. has been used in several traditional medicines against various diseases and this is based on its botanical, ethnopharmacology, and phytochemistry profiles. This powerful herb is recognized for its antibacterial, antifungal, antidiabetic, anticancer, antimutagenic, protective, and inflammatory hepatic activity. Multiple chemical compounds, including achrosine, aloe-emodin, emodin, anthraquinones, etc., have been isolated from this plant. The results of this bibliographic research thus presented in this review have demonstrated the ability of certain extracts from S. occidentalis L. to lower the lipid peroxide content, the activity of gamma-glutamyl transpeptidase and phospholipase A2 in exudates of the granuloma of cotton pellets, thus resulting in a reduced availability of arachidonic acid, an important precursor in the biosynthesis of prostaglandins, which are the only likely source and/or cause of dysmenorrhea. Thus, based on its phytochemical profile and its pharmacological properties, it is therefore suggested that S. occidentalis would be a potential and effective remedy in the treatment of dysmenorrhea.","PeriodicalId":11969,"journal":{"name":"European journal of medicinal plants","volume":"104 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82690604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-28DOI: 10.9734/ejmp/2022/v33i630471
D. Sharma, Naimish Purohit, Shiwa Chaubey, M. Tiwari, Mradu Bhadauriya, .. Mohit, Nilam Bhasker, Dharmendra Kumar
Aloe vera, a popular succulent perennial medicinal plant with a wide range of phytochemicals that have shown various pharmacological activities including anti-oxidant, antimicrobial, antidiabetic, wound healing promotion and so on. Acemannan, aloe-emodin, aloin, aloesin, and emodin are widely investigated active constituents that show various pharmacological activities. Thus, the purpose of this review is to highlight previous pharmacological studied conducted in vivo, in vitro and human assays over the past decades. As current pharmacological research is focused on anticancer and neurological action, it would be interesting and important to study the main compounds present in Aloe vera for therapeutic purposes.
{"title":"A Review on Pharmacological and Therapeutic Potential of Aloe barbadensis Miller","authors":"D. Sharma, Naimish Purohit, Shiwa Chaubey, M. Tiwari, Mradu Bhadauriya, .. Mohit, Nilam Bhasker, Dharmendra Kumar","doi":"10.9734/ejmp/2022/v33i630471","DOIUrl":"https://doi.org/10.9734/ejmp/2022/v33i630471","url":null,"abstract":"Aloe vera, a popular succulent perennial medicinal plant with a wide range of phytochemicals that have shown various pharmacological activities including anti-oxidant, antimicrobial, antidiabetic, wound healing promotion and so on. Acemannan, aloe-emodin, aloin, aloesin, and emodin are widely investigated active constituents that show various pharmacological activities. Thus, the purpose of this review is to highlight previous pharmacological studied conducted in vivo, in vitro and human assays over the past decades. As current pharmacological research is focused on anticancer and neurological action, it would be interesting and important to study the main compounds present in Aloe vera for therapeutic purposes.","PeriodicalId":11969,"journal":{"name":"European journal of medicinal plants","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82011527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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