European Journal of Dentistry最新文献

Malocclusion is an important dental health problem, especially in children. One factor causing malocclusion is the persistence of primary teeth, which genetic factors can influence. This study provides a new understanding of the role of genetics in causing malocclusion and its impact on preventive planning and orthodontic treatment.This was an observational analytic study with a cross-sectional research design. The research subjects were children of SD Pembangunan UNP Padang, Minangkabau tribe, aged 6 to 13 years, a total of 30 people, consisting of a case group and a control group. Saliva was collected using a nonstimulated method (passive salivation). The polymorphism of the RANKL rs9594738 gene was analyzed using the polymerase chain reaction-restriction fragment length polymorphism method. Amplification results were analyzed via agarose gel electrophoresis to determine genotype. Data analysis was performed using the chi-square test.RANKL rs9594738 gene polymorphism in the case group was higher than in the control group. The chi-square test shows an association between RANKL rs9594738 gene polymorphism and dental malocclusion due to the persistence of primary teeth.The data shows that the RANKL rs9594738 gene polymorphism is associated with dental malocclusion due to the persistence of primary teeth. The occurrence of malocclusion due to the persistence of primary teeth is a multigenetic phenomenon. In addition to the RANKL gene, osteoprotegerin, and matrix metalloproteinases, other genes that affect the replacement of primary teeth to permanent teeth are colony-stimulating factor 1, tumor necrosis factor ligand superfamily member 11, runt-related transcription factor 2, interleukin-1β, cathepsin K, sclerostin, and parathyroid hormone.

Sintering influences the optical properties of zirconia. This study examined the effect of altering sintering rates on color characteristics of 3, 4, and 5 mol% yttria (Y)-containing multilayer zirconia.A total of 135 specimens (width × length × thickness = 11.2 × 20 × 1.5 mm) were prepared from multilayer (cervical [C], middle [M], and incisal [I]) 3Y, 4Y, and 5Y zirconia, and randomly sintered at regular (RS: 10 °C/min), fast (FS: 35 °C/min), and speed (SS: 70 °C/min) sintering (n = 15/group). Translucency parameter (TP₀₀), contrast ratio (CR), opalescence parameter (OP), and color difference (∆E₀₀) were evaluated with the CIEL*a*b* system. Microstructure, crystalline (monoclinic [m], tetragonal [t], and cubic [c]) phases, and surface roughness (Ra) were evaluated by scanning electron microscopy (SEM), X-ray diffraction (XRD), and 3D-digital topography.ANOVA and Bonferroni comparisons were determined for significant differences (p < 0.05).Significant differences in TP₀₀, CR, OP, and ∆E₀₀ of zirconia types, layers, sintering rates, and their interactions were indicated (p < 0.05). Significant increases in TP₀₀ and ∆E₀₀, but decreases in CR and OP, upon rising the amount of Y (5Y > 4Y > 3Y), region (I > M > C), and speed sintering (SS > FS > RS) (p < 0.05) were observed. Nevertheless, the color alteration was within an acceptable threshold (∆E₀₀ ≤ 1.8); Ra values: 3Y > 4Y > 5Y. SEM indicated a larger grain for 5Y > 4Y > 3Y. XRD indicated higher t-phase in 3Y, whereas higher c-phase in 5Y.Increasing translucency and color alteration, and decreasing contrast and opalescence were influenced by Y content (5Y > 4Y > 3Y), region (I > M > C), and sintering rate (SS > FS > RS). Nonetheless, color alterations were within acceptable limits, suggesting the speed sintering rate to produce better color characteristics of restoration.

Mandibulofacial asymmetry can cause disharmony in facial appearance and smile and may also impair stomatognathic function and speech ability, negatively affecting psychological well-being and quality of life. This condition is also commonly associated with temporomandibular disorders (TMDs). This study aimed to analyze the relationship between mandibulofacial asymmetry and TMDs.This study conducted a cross-sectional study involving 42 patients (14 males and 28 females) aged 17 to 45 years. The diagnosis of TMDs was made using the Diagnostic Criteria for Temporomandibular Disorders, and facial asymmetry was assessed using frontal photography.The results showed that 76.2% of the patients with mandibulofacial asymmetry had a TMD. Statistical tests showed a relationship between mandibulofacial asymmetry and TMDs (p-value < 0.05).The TMD is closely related to mandibulofacial asymmetry. However, the relationship between mandibulofacial asymmetry and the specific categories of TMDs was not statistically significant, as determined by multinomial regression analysis.

Psychological factors and periodontitis are prevalent in geriatric populations, with evolving evidence suggesting potential associations. This systematic review comprehensively examines and evaluates the bidirectional relationship between psychological factors and periodontitis in older adults. Following PRISMA guidelines, systematic searches were conducted across PubMed, Google Scholar, Scopus, Embase, and Web of Science databases. The research question was structured using the PECO framework (P = older adults aged ≥ 60 years; E = presence of psychological factors; C = absence of psychological factors; O = periodontitis and its severity). Articles were selected based on predetermined inclusion/exclusion criteria, followed by data extraction. The Newcastle-Ottawa Scale assessed risk of bias and methodological quality, while the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) framework determined evidence certainty. Of 475 studies identified, 13 met the inclusion criteria for qualitative synthesis (8 on depression, 3 on stress, 1 on cognitive impairment, and 1 on examining multiple factors). For depression-periodontitis associations, results were inconsistent: four studies demonstrated positive associations, three found no significant relationship, and one had unclear findings. All three studies investigating stress-periodontitis relationships showed positive associations, suggesting a more consistent connection. The single study on cognitive impairment found significant independent associations with periodontitis after controlling for confounders. Only one longitudinal study (n = 11,454) revealed increased periodontitis risk at both 6-month and 1-year follow-ups in older adults with depression. Based on Newcastle-Ottawa Scale ratings, seven studies were deemed high quality, three moderate quality, and one low quality. GRADE assessment indicated very low certainty of evidence across all psychological factors, primarily due to methodological heterogeneity. This systematic review indicates significant associations between periodontal disease severity and psychological factors, particularly stress and cognitive impairment, in older adults. These findings suggest the importance of integrating psychological assessment into geriatric oral healthcare. More longitudinal research is needed to establish causality and bidirectional relationships, especially in middle- and low-income countries with a rapidly growing geriatric population. Mental health considerations should be incorporated into prevention and treatment strategies for periodontal disease in older adults.

Instruments are susceptible to deformation and/or fracture, which may represent a failure in endodontic treatment. This study assessed the mechanical properties of nickel-titanium rotary instruments through cyclic fatigue, buckling resistance, and 45° bending tests.One hundred and twenty rotary instruments were divided into three groups: Super Flexi Files Blue (SFB; 20/.04), TruNatomy Small (TN; 20/.04), and ProTaper Ultimate Shaper (PTU; 20/.04). They underwent cyclic fatigue tests at fixed and manufacturer-specified speeds, along with buckling and bending tests.SFB files exhibited the greatest cyclic fatigue resistance with the longest time to fracture and highest number of cycles to failure (NCF), followed by TN and PTU. For PTU and TN, reducing rotation speed increased time to fracture and NCF, while SFB showed reduced values with speed increase. TN exhibited the highest buckling resistance, whereas speed significantly affected cyclic fatigue resistance, with SFB being the most resistant overall. TN demonstrated notable buckling resistance and flexibility.The rotational speed significantly affects the resistance of instruments to cyclic fatigue and that the SFB file is the most resistant file to cyclic fatigue.

The new classification of periodontal and peri-implant diseases and conditions (2018) includes definitions of the respective diseases, modifications, and new additions to the 1999 classification. The purpose of the study was to present the opinion and level of understanding of Greek dentists regarding the new classification and to determine the approach for its establishment.A questionnaire consisting of 26 multiple-choice questions was distributed to Greek dentists in paper or digital form.Data were collected, recorded using Microsoft Excel, and were analyzed with SPSS 29.0 (IBM, United States).A total of 203 questionnaires were collected (49.3% male/50.2% female; mean age 39.02 years). 36.8% of the participants exclusively practiced periodontology and 44.8% general dentistry. Seventy-one participants were members of the Hellenic Society of Periodontology (HSP). 58.9% used the old classification system, which is reported as preferred by 53.5% of HSP members. Also, 53.3% of participants characterized the new classification as difficult to be applied, 47.1% of whom were HSP members. The most frequent reason for not using it (63/133) was the convenience of the older system application. A statistically significant higher percentage of HSP members correctly answered the comprehension questions (diagnostic criteria and clinical cases) of the questionnaire (z-test with Bonferroni correction < 0.05). Note that 79.7% of the participants stated that they should improve their knowledge regarding the new classification, mainly through seminars/courses.Most Greek dentists appear not to implement the 2018 classification system due to reported difficulty in understanding, while recognizing the need to comprehend and apply it to their clinical practice.

The objective of this study was to investigate the complex network of inflammasome-related biomarkers (NOD-like receptor thermal protein domain associated protein 3 [NLRP3], caspase-1, interleukin [IL]-1β, IL-18, and IL-37) in unstable periodontitis by examining the salivary concentrations of these specific biomarkers and correlating them with periodontal parameters.The design of this study was an observational case-control study. A salivary sample was collected from periodontally healthy patients (n = 40) and unstable periodontitis patients (n = 40). Full-mouth clinical periodontal parameters were recorded (plaque index, bleeding on probing, periodontal pocket depth, and clinical attachment loss). Enzyme-linked immunosorbent assay analyzed NLRP3, caspase-1, IL-1β, IL-18, and IL-37 salivary levels.The normality of the data was tested using the Shapiro-Wilk test. Mean, standard deviation, and percentages were used for data description. An independent sample t-test, Mann-Whitney U test, and chi-square test were used to compare the two groups with a p-value of < 0.05. Spearman's correlation analysis was conducted to examine the relationships between variables.In saliva samples, NLRP3, caspase-1, IL-1β, and IL-18 were the highest in the periodontitis group (p < 0.005), while IL-37 was highest in the healthy group (p < 0.005). There was significant (p < 0.012) negative weak correlation (-0.395) between IL-37 and IL-1β, and significant (p < 0.003) negative moderate correlation (-0.455) between IL-37 and IL-18 in the healthy group. A significant (0.031) positive weak correlation (0.342) was found between the salivary IL-37 and NLRP3, and a significant (p < 0.001) negative moderate correlation (-0.508) was found between salivary IL-37 and IL-1β, in the periodontitis group.The NLRP3 inflammasomes and their cytokines (caspase-1, IL-1β, and IL-18) significantly promote periodontal inflammation and tissue destruction. In contrast, IL-37 acts as an anti-inflammatory cytokine, inhibiting the activity of the NLRP3 inflammasome and reducing excessive inflammation. This interplay highlights the potential of targeting NLRP3 and enhancing IL-37 as a therapeutic approach for the treatment of periodontal disease.

Dry mouth is a common oral condition in older adults, which correlates with dehydration, pH changes, and lubrication in the oral cavity, leading to an imbalance among bacterial activities of dental biofilms. However, the role of dry mouth and periodontal status in older adults has remained limited, especially among periodontal individuals who underwent supportive periodontal therapy (SPT). This study aimed to investigate the association between dry mouth and recurrent periodontitis in older adults undergoing SPT.This cross-sectional study included patients who were part of SPT. The factors of interest were collected by interviews, questionnaires, and clinical assessments. Oral moisture measurement, the clinical oral dryness score, unstimulated salivary flow rate (USSFR), and stimulated salivary flow rate (SSFR) were performed. Full mouth periodontal examination was performed and compared with the previous record of periodontal examination to identify a recurrence of periodontitis based on bleeding on probing (BOP), a change in pocket depth, and clinical attachment level. Descriptive analysis, both univariate and multivariate logistic regression, was performed to delineate the association between dry mouth and recurrent periodontitis.A total of 186 participants were recruited and divided into the recurrent periodontitis (n = 37) and the nonrecurrent periodontitis group (n = 149). Baseline demographics, medical and dental history of the two groups were similar. Participants with hyposalivation were greater in the recurrent group (35.1 vs. 16.1%, p = 0.02), and the mean of USSFR is lower than the nonrecurrent periodontitis group (0.38 vs. 0.53 mL/min, p = 0.01). To examine the relationship between various factors affecting the recurrent periodontitis by using multivariate regression analysis, results demonstrated odds ratio (OR) of hyposalivation and percentage of BOP (%BOP) in recurrent periodontitis at 2.63 (95% CI = 1.05-6.58), p = 0.04 and 1.04 (95% CI = 1.02-1.06), p < 0.001 after adjusting for confounding factors.This study supported the hypothesis that hyposalivation is associated with recurrent periodontitis demonstrated by USSFR and %BOP association. Consistent periodontal care, including an examination and guidance on managing dry mouth, has the potential to help older individuals with periodontitis maintaining their dental health.

This systematic literature review aimed to evaluate the accuracy of the stereophotogrammetry based dental scanners in determining complete-arch implant retained prosthesis compared to intraoral scanners (IOSs). The focused PICO (Population, Intervention, Comparison, Outcome) directed was "Do complete arch implant (P) impressions made using stereophotogrammetry-based dental scanners (I) have the same accuracy (O) when compared to impressions made using IOS (C)?" Recommendations listed by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) were used for structuring and reporting this review. This systematic review and meta-analysis was preregistered in the International Prospective Register of Systematic Reviews (PROSPERO) bearing the registration number CRD42024597913. To search the relevant titles, four electronic databases (MEDLINE/PubMed, Scopus, Cochrane Library, and Web of Science) were systematically searched in October 2024. The inclusion criteria include research papers published up to September 2024 in English comparing the accuracy of stereophotogrammetry-based dental scanners with IOS in recording the impression of complete-arch implants. Studies conducted on animals were excluded. Also excluded were unpublished reports, theses and dissertations, and case reports. After the initial search of the selected databases, a total of 590 titles were identified. The synthesis included 13 articles for qualitative analysis, but only 8 provided comparative data for quantitative analysis, which was performed using review manager (RevMan) Version 5.4. in non-Cochrane mode. The Modified CONSORT scale was used for in vitro quality and risk-of-bias assessment, while the QUADAS-2 tool was utilized for in vivo studies. The systematic review and meta-analysis reveals that stereophotogrammetric-based dental scanners offer higher accuracy in recording complete-arch implant-supported prosthesis impressions compared to IOS. The current review and meta-analysis compared of the accuracy of stereophotogrammetry-based dental scanners with IOSs. Limitations include medium to high quality of selected studies, with most of the in vitro studies displaying a high risk of bias, high heterogeneity in the control groups, and generalizability concerns. Accuracy of dental implant impressions is influenced by the type of scanner used for scanning. Stereophotogrammetry-based dental scanners are more accurate than IOS.

Honey and propolis, recognized for their antimicrobial, antioxidant, and wound-healing properties, have gained attention as potential adjuncts in dental implantology. This systematic review aimed to assess and summarize existing evidence regarding the antibacterial, healing, and osseointegration effects of honey- and propolis-based agents when used in dental implant therapy, and to evaluate their impact on implant success and survival. A systematic search was conducted in accordance with the PRISMA guidelines across the PubMed, Scopus, Web of Science and Google Scholar databases up to June 2025. Eligible studies included clinical trials, animal experiments, and in vitro investigations that utilized honey or propolis in procedures related to dental implants. Assessed outcomes encompassed implant success, antimicrobial activity, osseointegration, tissue healing, and biocompatibility. Risk of bias was evaluated using appropriate assessment tools, and the results were synthesized descriptively. Fifteen studies were included (3 clinical, 6 animal, and 6 in vitro studies). Honey and propolis demonstrated strong antibacterial activity against Staphylococcus aureus and Staphylococcus mutans, supported bone healing, reduced oxidative stress, and exhibited biocompatibility. Honey-based surface coatings enhanced antibacterial effects and osteogenic responses. Clinical studies have reported improvements in peri-implant parameters with propolis gels and toothpaste; however, the evidence remains limited, and most studies carried a moderate risk of bias. Overall, these agents exhibit promising antibacterial, healing, and osseointegration effects in preclinical research; however, their impact on dental implant outcomes remains uncertain, necessitating more robust clinical trials.