European Journal of Radiology最新文献_第2页

New strategy of LI-RADS v2018 to improve the sensitivity for small hepatocellular carcinoma ≤ 3.0 cm on extracellular-contrast enhanced MRI LI-RADS v2018提高细胞外对比增强磁共振成像对≤3.0厘米小肝细胞癌敏感性的新策略。

IF 3.2 3区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

European Journal of Radiology

Pub Date : 2024-11-09 DOI: 10.1016/j.ejrad.2024.111830

Jinhui Zhou , Yao Zhang , Jing Zhang , Jingbiao Chen , Hang Jiang , Linqi Zhang , Xi Zhong , Tianhui Zhang , Lichun Chen , Yufeng Wang , Yikai Xu , Jin Wang

Introduction

We aimed to modify LI-RADS version 2018 to improve sensitivity and determine the value of the combination of high alpha-fetoprotein (AFP) levels for small HCC (sHCC, ≤ 30 mm) diagnosis.

Methods

A total of 984 patients at high risk for HCC, with 1204 observations (including 997 small observations ≤ 30 mm), who underwent extracellular contrast-enhanced MRI were enrolled from five independent centers. Blinded readers evaluated the LI-RADS features and categorized each observation according to the LI-RADS v2018, modified LI-RADS and EASL. Odds ratios of LI-RADS major features (MFs) and several high AFP levels for sHCC diagnosis were analyzed using multivariable logistic regression. The modified LR-5 criteria was developed by including no APHE at any size with two MFs, and non-rim APHE with one MF (≥ 10 mm) or with two MFs (< 10 mm). The diagnostic performance of each version of the LR-5 was compared using generalized estimating equations.

Results

APHE, washout, enhancing capsule and five high AFP levels were independently associated with sHCC. In three datasets, the modified LI-RADS had higher sensitivities for sHCC (76.8 ∼ 85.5 % vs. 73.7 ∼ 75.9 %, P < 0.05) to the LR-5 v2018. The modified LI-RADS with AFP ≥ 200 ng/mL as an additional feature or as an alternative to threshold growth provided higher sensitivities for sHCC than LI-RADS v2018 (82.1 ∼ 90.1 % vs. 73.7 ∼ 75.9 %, all P < 0.05), modified LI-RADS (82.1 ∼ 90.1 % vs. 76.8 ∼ 85.5 %, all P < 0.05) and EASL version 2018 (82.1 ∼ 90.1 % vs. 73.3 ∼ 74.7 %, all P < 0.05), with comparable specificities (all P > 0.05).

Conclusion

The new strategy of LI-RADS v2018 provides significantly higher sensitivity and comparable specificity than those of LI-RADS v2018 for sHCC diagnosis on ECA-MRI.

导言：我们旨在修改LI-RADS 2018版，以提高灵敏度，并确定高甲胎蛋白（AFP）水平对小HCC（sHCC，≤30 mm）诊断的组合价值：方法：五个独立中心共招募了984名HCC高危患者，对其进行了1204次观察（包括997次小于30毫米的观察），并对其进行了细胞外造影剂增强磁共振成像。双盲读者评估了LI-RADS特征，并根据LI-RADS v2018、修改后的LI-RADS和EASL对每个观察结果进行了分类。使用多变量逻辑回归分析了LI-RADS主要特征（MFs）和几种高AFP水平与sHCC诊断的比值比。修正的LR-5标准包括无任何大小的APHE但有两个MFs，以及无缘APHE但有一个MFs（≥ 10 mm）或两个MFs（< 10 mm）。使用广义估计方程比较了各版本 LR-5 的诊断性能：结果：APHE、冲洗、增强囊和五个高AFP水平与sHCC独立相关。在三个数据集中，改良的LI-RADS对sHCC的敏感性（76.8 ∼ 85.5 % vs. 73.7 ∼ 75.9 %，P < 0.05）高于LR-5 v2018。将甲胎蛋白≥ 200 ng/mL 作为附加特征或替代阈值增长的改进型 LI-RADS 对 sHCC 的灵敏度高于 LI-RADS v2018（82.1 ∼ 90.1 % vs. 73.7 ∼ 75.9 %，均 P < 0.05）、改良LI-RADS（82.1 ∼ 90.1 % vs. 76.8 ∼ 85.5 %，均P < 0.05）和EASL 2018版（82.1 ∼ 90.1 % vs. 73.3 ∼ 74.7 %，均P < 0.05），特异性相当（均P > 0.05）：结论：与LI-RADS v2018相比，LI-RADS v2018的新策略在ECA-MRI诊断sHCC方面具有明显更高的灵敏度和相当的特异性。

{"title":"New strategy of LI-RADS v2018 to improve the sensitivity for small hepatocellular carcinoma ≤ 3.0 cm on extracellular-contrast enhanced MRI","authors":"Jinhui Zhou , Yao Zhang , Jing Zhang , Jingbiao Chen , Hang Jiang , Linqi Zhang , Xi Zhong , Tianhui Zhang , Lichun Chen , Yufeng Wang , Yikai Xu , Jin Wang","doi":"10.1016/j.ejrad.2024.111830","DOIUrl":"10.1016/j.ejrad.2024.111830","url":null,"abstract":"<div><h3>Introduction</h3><div>We aimed to modify LI-RADS version 2018 to improve sensitivity and determine the value of the combination of high alpha-fetoprotein (AFP) levels for small HCC (sHCC, ≤ 30 mm) diagnosis.</div></div><div><h3>Methods</h3><div>A total of 984 patients at high risk for HCC, with 1204 observations (including 997 small observations ≤ 30 mm), who underwent extracellular contrast-enhanced MRI were enrolled from five independent centers. Blinded readers evaluated the LI-RADS features and categorized each observation according to the LI-RADS v2018, modified LI-RADS and EASL. Odds ratios of LI-RADS major features (MFs) and several high AFP levels for sHCC diagnosis were analyzed using multivariable logistic regression. The modified LR-5 criteria was developed by including no APHE at any size with two MFs, and non-rim APHE with one MF (≥ 10 mm) or with two MFs (< 10 mm). The diagnostic performance of each version of the LR-5 was compared using generalized estimating equations.</div></div><div><h3>Results</h3><div>APHE, washout, enhancing capsule and five high AFP levels were independently associated with sHCC. In three datasets, the modified LI-RADS had higher sensitivities for sHCC (76.8 ∼ 85.5 % vs. 73.7 ∼ 75.9 %, P < 0.05) to the LR-5 v2018. The modified LI-RADS with AFP ≥ 200 ng/mL as an additional feature or as an alternative to threshold growth provided higher sensitivities for sHCC than LI-RADS v2018 (82.1 ∼ 90.1 % vs. 73.7 ∼ 75.9 %, all P < 0.05), modified LI-RADS (82.1 ∼ 90.1 % vs. 76.8 ∼ 85.5 %, all P < 0.05) and EASL version 2018 (82.1 ∼ 90.1 % vs. 73.3 ∼ 74.7 %, all P < 0.05), with comparable specificities (all P > 0.05).</div></div><div><h3>Conclusion</h3><div>The new strategy of LI-RADS v2018 provides significantly higher sensitivity and comparable specificity than those of LI-RADS v2018 for sHCC diagnosis on ECA-MRI.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"181 ","pages":"Article 111830"},"PeriodicalIF":3.2,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142638069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bias in the shadows: The need for tools to foster gender and sex equity in medical journals 阴影中的偏见：需要工具来促进医学期刊中的性别平等。

IF 3.2 3区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

European Journal of Radiology

Pub Date : 2024-11-09 DOI: 10.1016/j.ejrad.2024.111823

Valeria Noguera , Karen Cifuentes , Gustavo Adolfo Triana Rodriguez

引用次数: 0

Cartilage T2 mapping-based radiomics in knee osteoarthritis research: Status, progress and future outlook 基于软骨 T2 图谱的膝关节骨关节炎放射组学研究：现状、进展和未来展望

IF 3.2 3区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

European Journal of Radiology

Pub Date : 2024-11-08 DOI: 10.1016/j.ejrad.2024.111826

Shi Gao , Chengbao Peng , Guan Wang , Chunbo Deng , Zhan Zhang , Xueyong Liu

Osteoarthritis (OA) affects more than 500 millions people worldwide and places an enormous economic and medical burden on patients and healthcare systems. The knee is the most commonly affected joint. However, there is no effective early diagnostic method for OA. The main pathological feature of OA is cartilage degeneration. Owing to the poor regenerative ability of chondrocytes, early detection of OA and prompt intervention are extremely important. The T2 relaxation time indicates changes in cartilage composition and responds to alterations in the early cartilage matrix. T2 mapping does not require contrast agents or special equipment, so it is widely used. Radiomics analysis methods are used to construct diagnostic or predictive models based on information extracted from clinical images. Owing to the development of artificial intelligence methods, radiomics has made excellent progress in segmentation and model construction. In this review, we summarize the progress of T2 mapping radiomics research methods in terms of T2 map acquisition, image postprocessing, and OA diagnosis or predictive model construction.

骨关节炎（OA）影响着全球 5 亿多人，给患者和医疗系统带来了巨大的经济和医疗负担。膝关节是最常受影响的关节。然而，目前还没有有效的 OA 早期诊断方法。OA 的主要病理特征是软骨退化。由于软骨细胞再生能力差，因此早期发现 OA 并及时干预极为重要。T2弛豫时间显示软骨成分的变化，并对早期软骨基质的改变做出反应。T2 显像不需要造影剂或特殊设备，因此被广泛应用。放射组学分析方法用于根据从临床图像中提取的信息构建诊断或预测模型。由于人工智能方法的发展，放射组学在分割和模型构建方面取得了长足的进步。在这篇综述中，我们将从T2图采集、图像后处理、OA诊断或预测模型构建等方面总结T2图放射组学研究方法的进展。

{"title":"Cartilage T2 mapping-based radiomics in knee osteoarthritis research: Status, progress and future outlook","authors":"Shi Gao , Chengbao Peng , Guan Wang , Chunbo Deng , Zhan Zhang , Xueyong Liu","doi":"10.1016/j.ejrad.2024.111826","DOIUrl":"10.1016/j.ejrad.2024.111826","url":null,"abstract":"<div><div>Osteoarthritis (OA) affects more than 500 millions people worldwide and places an enormous economic and medical burden on patients and healthcare systems. The knee is the most commonly affected joint. However, there is no effective early diagnostic method for OA. The main pathological feature of OA is cartilage degeneration. Owing to the poor regenerative ability of chondrocytes, early detection of OA and prompt intervention are extremely important. The T2 relaxation time indicates changes in cartilage composition and responds to alterations in the early cartilage matrix. T2 mapping does not require contrast agents or special equipment, so it is widely used. Radiomics analysis methods are used to construct diagnostic or predictive models based on information extracted from clinical images. Owing to the development of artificial intelligence methods, radiomics has made excellent progress in segmentation and model construction. In this review, we summarize the progress of T2 mapping radiomics research methods in terms of T2 map acquisition, image postprocessing, and OA diagnosis or predictive model construction.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"181 ","pages":"Article 111826"},"PeriodicalIF":3.2,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142617558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment and integration of multiparametric MRI for liver fibrosis staging in rat non-alcoholic steatohepatitis: Evaluation of diagnostic efficiency and model interpretation 评估和整合用于大鼠非酒精性脂肪性肝炎肝纤维化分期的多参数磁共振成像：诊断效率评估和模型解释

IF 3.2 3区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

European Journal of Radiology

Pub Date : 2024-11-08 DOI: 10.1016/j.ejrad.2024.111821

Zhaoshu Huang , Xing Xia , Yao Liang , Yong Wen , Meihua Yang , Yue Pan , Peng Luo , Pinggui Lei

Objectives

Multiparametric magnetic resonance imaging (mpMRI) techniques, including intravoxel incoherence motion (IVIM), iterative decomposition of water and fat with echo asymmetry and least-squares estimation quantification sequence (IDEAL IQ), T2* mapping and T2 mapping, were employed to develop and validate a predictive model for non-alcoholic steatohepatitis (NASH) diagnosis and liver fibrosis (LF) staging in rats. The combined model was interpreted using SHapley Additive exPlanations (SHAP) values for model interpretation.

Materials and methods

160 healthy Sprague-Dawley (SD) rats were divided into control (n = 24) and experimental (n = 136) groups, and the 12-week and 16-week groups were injected intraperitoneally with carbon tetrachloride (CCl4) for 4 weeks, one month before the final feeding period. All rats were subjected to pathological examination to determine LF stage. Upon the study’s completion, 147 SD rats were assessed for liver fibrosis.

Results

84 SD rats were diagnosed with NASH and 31, 10, and 43 rats were histologically diagnosed with no fibrosis (F0), early LF (F1-F2), and advanced LF (F3-F4). For diagnosis of NASH and staging of liver fibrosis associated with NASH, a combined mpMRI prediction model has a higher area under the receiver operating characteristic(ROC) curve (AUC) than uniparameters, especially in advanced stages of fibrosis, with an AUC of 0.929 for the combined model. In SHAP, the fat fraction(FF) value contributes most to the model for diagnosing NASH and advanced liver fibrosis, while the T2 value contributes most for diagnosing liver fibrosis and the apparent diffusion coefficient (ADC) value contributes most for diagnosing liver cirrhosis.

Conclusions

The mpMRI could be used to evaluate the severity of liver fibrosis in the context of NASH. Combined with SHAP value analysis, this approach can help to understand the contribution of each mpMRI feature to the predictive model.

目的采用多参数磁共振成像（mpMRI）技术，包括体细胞内不相干运动（IVIM）、回波不对称和最小二乘估计量化序列（IDEAL IQ）的水和脂肪迭代分解、T2*映射和T2映射，开发并验证大鼠非酒精性脂肪性肝炎（NASH）诊断和肝纤维化（LF）分期的预测模型。材料和方法160只健康的Sprague-Dawley（SD）大鼠分为对照组（n = 24）和实验组（n = 136），12周组和16周组在最后喂养期前一个月腹腔注射四氯化碳（CCl4）4周。对所有大鼠进行病理检查，以确定 LF 阶段。结果84只SD大鼠被诊断为NASH，31只、10只和43只大鼠被组织学诊断为无纤维化（F0）、早期LF（F1-F2）和晚期LF（F3-F4）。对于 NASH 的诊断和 NASH 相关肝纤维化的分期，mpMRI 组合预测模型的接收器操作特征曲线下面积（AUC）高于单参数，尤其是在纤维化晚期，组合模型的 AUC 为 0.929。在SHAP中，脂肪分数（FF）值对诊断NASH和晚期肝纤维化模型的贡献最大，而T2值对诊断肝纤维化的贡献最大，表观弥散系数（ADC）值对诊断肝硬化的贡献最大。结合 SHAP 值分析，这种方法有助于了解每个 mpMRI 特征对预测模型的贡献。

{"title":"Assessment and integration of multiparametric MRI for liver fibrosis staging in rat non-alcoholic steatohepatitis: Evaluation of diagnostic efficiency and model interpretation","authors":"Zhaoshu Huang , Xing Xia , Yao Liang , Yong Wen , Meihua Yang , Yue Pan , Peng Luo , Pinggui Lei","doi":"10.1016/j.ejrad.2024.111821","DOIUrl":"10.1016/j.ejrad.2024.111821","url":null,"abstract":"<div><h3>Objectives</h3><div>Multiparametric magnetic resonance imaging (mpMRI) techniques, including intravoxel incoherence motion (IVIM), iterative decomposition of water and fat with echo asymmetry and least-squares estimation quantification sequence (IDEAL IQ), T2* mapping and T2 mapping, were employed to develop and validate a predictive model for non-alcoholic steatohepatitis (NASH) diagnosis and liver fibrosis (LF) staging in rats. The combined model was interpreted using SHapley Additive exPlanations (SHAP) values for model interpretation.</div></div><div><h3>Materials and methods</h3><div>160 healthy Sprague-Dawley (SD) rats were divided into control (n = 24) and experimental (n = 136) groups, and the 12-week and 16-week groups were injected intraperitoneally with carbon tetrachloride (CCl4) for 4 weeks, one month before the final feeding period. All rats were subjected to pathological examination to determine LF stage. Upon the study’s completion, 147 SD rats were assessed for liver fibrosis.</div></div><div><h3>Results</h3><div>84 SD rats were diagnosed with NASH and 31, 10, and 43 rats were histologically diagnosed with no fibrosis (F0), early LF (F1-F2), and advanced LF (F3-F4). For diagnosis of NASH and staging of liver fibrosis associated with NASH, a combined mpMRI prediction model has a higher area under the receiver operating characteristic(ROC) curve (AUC) than uniparameters, especially in advanced stages of fibrosis, with an AUC of 0.929 for the combined model. In SHAP, the fat fraction(FF) value contributes most to the model for diagnosing NASH and advanced liver fibrosis, while the T2 value contributes most for diagnosing liver fibrosis and the apparent diffusion coefficient (ADC) value contributes most for diagnosing liver cirrhosis.</div></div><div><h3>Conclusions</h3><div>The mpMRI could be used to evaluate the severity of liver fibrosis in the context of NASH. Combined with SHAP value analysis, this approach can help to understand the contribution of each mpMRI feature to the predictive model.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"182 ","pages":"Article 111821"},"PeriodicalIF":3.2,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142660898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Eosinophilic gastroenteritis: Imaging spectrum on intestinal ultrasonography and CT enterography 嗜酸性粒细胞肠胃炎：肠道超声波和 CT 肠道造影的成像谱。

IF 3.2 3区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

European Journal of Radiology

Pub Date : 2024-11-08 DOI: 10.1016/j.ejrad.2024.111820

Li Ma , Wenbo Li , Mengsu Xiao , Wei Liu , Jingjuan Liu , Weixun Zhou , Xinxin Mao , Ji Li , Qingli Zhu

Rationale and objectives

Diagnostic delays are common in eosinophilic gastroenteritis (EGE). This study aimed to evaluate the value of imaging modalities in facilitating the diagnosis of EGE.

Materials and methods

Patients diagnosed with EGE who underwent either intestinal ultrasound (IUS) or computer tomography enterography (CTE) were retrospectively recruited. Medical records were reviewed for clinical information, while IUS and CTE images were reviewed to summarize characteristic findings. Imaging characteristics of EGE subtypes were also evaluated.

Results

A total of 51 patients were included, with 30 undergoing IUS examinations and 42 undergoing CTE examinations. Positive findings were observed in 22 (73.3 %) patients on IUS and 32 (76.2 %) on CTE. In both modalities, the small intestine was the most commonly involved site (88.9 % on IUS and 90.6 % on CTE), with lesions predominantly diffuse (72.2 % on IUS and 75.0 % on CTE). IUS also revealed clear bowel wall stratification in 94.4 % of patients and identified a specific “piano key sign” in 22.2 % of patients. Thirty-six (70.6 %) patients were categorized into the mucosal subtype, 4 (7.8 %) muscular subtype, and 11 (21.6 %) serosal subtype. Most patients with the muscular and serosal subtypes exhibited typical manifestations (100 % and 81.8 %, respectively), while 63.9 % of patients with the mucosal subtype showed unremarkable or nonspecific imaging findings. No significant differences of baseline imaging characteristics were found between relieved and relapsed groups (P = 0.13).

Conclusion

Characteristic imaging findings of EGE include small intestine involvement, diffuse lesions, clear bowel wall stratification, and the “piano key sign”. Imaging modalities can be useful tools to facilitate the diagnosis of EGE, especially for the muscular and serosal subtypes.

理由和目标：嗜酸性粒细胞性胃肠炎（EGE）的诊断延误很常见。本研究旨在评估成像模式在促进 EGE 诊断方面的价值：回顾性招募被诊断为 EGE 的患者，这些患者均接受了肠道超声检查（IUS）或计算机断层扫描肠造影术（CTE）。回顾病历以了解临床信息，同时回顾 IUS 和 CTE 图像以总结特征性发现。同时还评估了 EGE 亚型的成像特征：共纳入 51 名患者，其中 30 人接受了 IUS 检查，42 人接受了 CTE 检查。在接受 IUS 检查的患者中，有 22 人（73.3%）观察到阳性结果，在接受 CTE 检查的患者中，有 32 人（76.2%）观察到阳性结果。在这两种检查方式中，小肠是最常受累的部位（IUS 为 88.9%，CTE 为 90.6%），病变以弥漫性为主（IUS 为 72.2%，CTE 为 75.0%）。IUS 还显示 94.4% 的患者肠壁分层清晰，并在 22.2% 的患者中发现了特定的 "钢琴键征"。36 例（70.6%）患者被分为粘膜亚型，4 例（7.8%）为肌肉亚型，11 例（21.6%）为浆膜亚型。大多数肌肉亚型和浆膜亚型患者都有典型表现（分别为 100% 和 81.8%），而 63.9% 的粘膜亚型患者没有明显或非特异性的影像学表现。缓解组和复发组的基线影像特征无明显差异（P = 0.13）：结论：EGE 的特征性影像学表现包括小肠受累、病变弥漫、肠壁分层清晰和 "钢琴键征"。影像学模式是诊断 EGE 的有用工具，尤其是对肌肉型和浆膜型亚型。

{"title":"Eosinophilic gastroenteritis: Imaging spectrum on intestinal ultrasonography and CT enterography","authors":"Li Ma , Wenbo Li , Mengsu Xiao , Wei Liu , Jingjuan Liu , Weixun Zhou , Xinxin Mao , Ji Li , Qingli Zhu","doi":"10.1016/j.ejrad.2024.111820","DOIUrl":"10.1016/j.ejrad.2024.111820","url":null,"abstract":"<div><h3>Rationale and objectives</h3><div>Diagnostic delays are common in eosinophilic gastroenteritis (EGE). This study aimed to evaluate the value of imaging modalities in facilitating the diagnosis of EGE.</div></div><div><h3>Materials and methods</h3><div>Patients diagnosed with EGE who underwent either intestinal ultrasound (IUS) or computer tomography enterography (CTE) were retrospectively recruited. Medical records were reviewed for clinical information, while IUS and CTE images were reviewed to summarize characteristic findings. Imaging characteristics of EGE subtypes were also evaluated.</div></div><div><h3>Results</h3><div>A total of 51 patients were included, with 30 undergoing IUS examinations and 42 undergoing CTE examinations. Positive findings were observed in 22 (73.3 %) patients on IUS and 32 (76.2 %) on CTE. In both modalities, the small intestine was the most commonly involved site (88.9 % on IUS and 90.6 % on CTE), with lesions predominantly diffuse (72.2 % on IUS and 75.0 % on CTE). IUS also revealed clear bowel wall stratification in 94.4 % of patients and identified a specific “piano key sign” in 22.2 % of patients. Thirty-six (70.6 %) patients were categorized into the mucosal subtype, 4 (7.8 %) muscular subtype, and 11 (21.6 %) serosal subtype. Most patients with the muscular and serosal subtypes exhibited typical manifestations (100 % and 81.8 %, respectively), while 63.9 % of patients with the mucosal subtype showed unremarkable or nonspecific imaging findings. No significant differences of baseline imaging characteristics were found between relieved and relapsed groups (P = 0.13).</div></div><div><h3>Conclusion</h3><div>Characteristic imaging findings of EGE include small intestine involvement, diffuse lesions, clear bowel wall stratification, and the “piano key sign”. Imaging modalities can be useful tools to facilitate the diagnosis of EGE, especially for the muscular and serosal subtypes.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"181 ","pages":"Article 111820"},"PeriodicalIF":3.2,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142617572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Angiographic reconstructions of CT perfusion for occlusion detection in ischemic stroke 用于缺血性中风闭塞检测的 CT 灌注血管造影重建。

IF 3.2 3区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

European Journal of Radiology

Pub Date : 2024-11-08 DOI: 10.1016/j.ejrad.2024.111819

M.M.Q Robbe , F.M.E Pinckaers , B.A.J.M. Wagemans , R.J van Oostenbrugge , W.H van Zwam , J. Staals , A.A. Postma

Background

Both CT angiography and CT perfusion involve the administration and tracking of a contrast medium bolus for different purposes. In this study, we aim to compare the diagnostic accuracy and subjective image quality of CTP-angiographic reconstructions with conventional CTA for occlusion detection in ischemic stroke patients.

Methods

In this retrospective study, patients with a final diagnosis of ischemic stroke and who underwent both CTA and CTP from September 2020 up to and including September 2021 were included. CTP-AR was reconstructed from the 1 mm CTP series at the time of maximum arterial inflow. Three reviewers with different levels of experience assessed both CTA and CTP for occlusion detection, expressed certainty, and rated subjective image quality. The reference standard was set at the consensus meeting. Pooled sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated. Differences in subjective and objective image quality and certainty were assessed using Kendall’s tau correlation and paired samples t-tests.

Results

In total, 107/210 included patients had an occlusion based on our reference standard. Pooled sensitivity and specificity for occlusion detection were 90% (95%CI 85–93) and 94% (95%CI 90–97) for CTA, and 89% (95%CI 84–93) and 93% (95%CI 89–96) for CTP-AR, respectively. The pooled certainty did not significantly differ between CTA and CTP-AR (P=.43). The pooled subjective image quality scores significantly differed between CTA and CTP-AR (τ = 0.3, P<.001), where one reviewer rated subjective image quality higher in CTA and two reviewer in CTP-AR.

Conclusion

CTP-AR has comparable diagnostic accuracy to conventional CTA imaging for occlusion detection in ischemic stroke patients. Thus, using CTP-AR instead of CTA plus CTP may conserve contrast medium.

背景：CT 血管造影和 CT 灌注都涉及造影剂栓剂的给药和跟踪，目的各不相同。在本研究中，我们旨在比较 CTP 血管造影重建与传统 CTA 在缺血性脑卒中患者闭塞检测中的诊断准确性和主观图像质量：在这项回顾性研究中，纳入了自 2020 年 9 月至 2021 年 9 月（含 2021 年 9 月）最终诊断为缺血性卒中并同时接受 CTA 和 CTP 检查的患者。CTP-AR 由动脉流入量最大时的 1 mm CTP 系列重建。三位具有不同经验水平的评审员对 CTA 和 CTP 的闭塞检测进行了评估，表达了确定性，并对图像质量进行了主观评分。参考标准在共识会议上确定。计算汇总的敏感性、特异性、阳性预测值（PPV）和阴性预测值（NPV）。使用 Kendall's tau 相关性和配对样本 t 检验评估主观和客观图像质量及确定性的差异：结果：根据我们的参考标准，共有 107/210 例患者出现闭塞。CTA和CTP-AR检测闭塞的汇总灵敏度和特异度分别为90%（95%CI 85-93）和94%（95%CI 90-97）和89%（95%CI 84-93）和93%（95%CI 89-96）。CTA 和 CTP-AR 的综合确定性无明显差异（P=.43）。CTA和CTP-AR的汇总主观图像质量评分有明显差异（τ = 0.3，PC结论：在缺血性卒中患者闭塞检测方面，CTP-AR 的诊断准确性与传统 CTA 成像相当。因此，使用 CTP-AR 代替 CTA 加 CTP 可以节省造影剂。

{"title":"Angiographic reconstructions of CT perfusion for occlusion detection in ischemic stroke","authors":"M.M.Q Robbe , F.M.E Pinckaers , B.A.J.M. Wagemans , R.J van Oostenbrugge , W.H van Zwam , J. Staals , A.A. Postma","doi":"10.1016/j.ejrad.2024.111819","DOIUrl":"10.1016/j.ejrad.2024.111819","url":null,"abstract":"<div><h3>Background</h3><div>Both CT angiography and CT perfusion involve the administration and tracking of a contrast medium bolus for different purposes. In this study, we aim to compare the diagnostic accuracy and subjective image quality of CTP-angiographic reconstructions with conventional CTA for occlusion detection in ischemic stroke patients.</div></div><div><h3>Methods</h3><div>In this retrospective study, patients with a final diagnosis of ischemic stroke and who underwent both CTA and CTP from September 2020 up to and including September 2021 were included. CTP-AR was reconstructed from the 1 mm CTP series at the time of maximum arterial inflow. Three reviewers with different levels of experience assessed both CTA and CTP for occlusion detection, expressed certainty, and rated subjective image quality. The reference standard was set at the consensus meeting. Pooled sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated. Differences in subjective and objective image quality and certainty were assessed using Kendall’s tau correlation and paired samples t-tests.</div></div><div><h3>Results</h3><div>In total, 107/210 included patients had an occlusion based on our reference standard. Pooled sensitivity and specificity for occlusion detection were 90% (95%CI 85–93) and 94% (95%CI 90–97) for CTA, and 89% (95%CI 84–93) and 93% (95%CI 89–96) for CTP-AR, respectively. The pooled certainty did not significantly differ between CTA and CTP-AR (<em>P=</em>.43). The pooled subjective image quality scores significantly differed between CTA and CTP-AR (τ = 0.3, <em>P</em><.001), where one reviewer rated subjective image quality higher in CTA and two reviewer in CTP-AR.</div></div><div><h3>Conclusion</h3><div>CTP-AR has comparable diagnostic accuracy to conventional CTA imaging for occlusion detection in ischemic stroke patients. Thus, using CTP-AR instead of CTA plus CTP may conserve contrast medium.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"181 ","pages":"Article 111819"},"PeriodicalIF":3.2,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142638733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current Status of the clinical role in Spanish interventional radiology: An online survey among the Spanish Society of Vascular and Interventional Radiology (SERVEI) members 西班牙介入放射学的临床角色现状：西班牙血管和介入放射学会 (SERVEI) 会员在线调查。

IF 3.2 3区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

European Journal of Radiology

Pub Date : 2024-11-08 DOI: 10.1016/j.ejrad.2024.111829

Pedro Blas García Jurado , Juan José Espejo Herrero , María Sagrario Lombardo Galera , María Eugenia Pérez Montilla , Sara Barranco Acosta , José García-Revillo , Pilar Font Ugalde , Marina Álvarez Benito

Purpose

This work aims to provide an overview of the current reality of clinical practice in interventional radiology in Spain, evaluating clinical activity, interventional radiologists’ opinion on the importance of playing a proactive clinical role, and the barriers they encounter in doing so.

Materials and Methods

The study was based on an 18-question survey divided into four categories: general aspects, clinical activity, opinion on a proactive clinical role, and barriers. The questionnaire, validated by the Spanish Society of Vascular and Interventional Radiology (SERVEI), was distributed to all members (n = 483) via email. A descriptive statistical analysis was performed.

Results

The response rate was 26.5% (128/483). A total of 44.5% (57/128) had admitting privileges, 70.3% (90/128) had consultations, 32.8% (42/128) did ward rounds, and 94.5% (121/128) participated in multidisciplinary committees. Most spent just 0%–10% of their workday on clinical activity. A total of 43.7% (56/128) reported providing longitudinal care for their patients. On a Likert scale from 1 to 10, the importance of performing pre-procedural consultations was rated a mean of 8.3 (IQR: 10–8), post-procedural consultations 8.1 (IQR: 10–7), and care during hospitalization 7.7 (IQR: 10–6). The main obstacles were a lack of time/excessive workload and inadequate professional resources.

Conclusions

Spanish interventional radiologists demonstrated a clear awareness of the importance of providing longitudinal patient care. However, they reported only partially taking on the clinical responsibilities for the patients they treated.

目的：本研究旨在概述西班牙介入放射学临床实践的现状，评估临床活动、介入放射医师对发挥积极主动的临床作用的重要性的看法，以及他们在发挥积极主动的临床作用时遇到的障碍：研究基于一项 18 个问题的调查，分为四个类别：一般方面、临床活动、对积极主动的临床角色的看法以及障碍。问卷经西班牙血管和介入放射学会（SERVEI）验证后，通过电子邮件分发给所有会员（n = 483）。对问卷进行了描述性统计分析：结果：回复率为 26.5%（128/483）。共有 44.5%（57/128）的成员拥有入院特权，70.3%（90/128）的成员进行会诊，32.8%（42/128）的成员进行查房，94.5%（121/128）的成员参加了多学科委员会。大多数人每天的临床活动时间仅占 0%-10%。共有 43.7%（56/128）的人表示为病人提供了纵向护理。在 1-10 分的李克特量表中，术前会诊的重要性平均为 8.3 分（IQR：10-8），术后会诊为 8.1 分（IQR：10-7），住院期间的护理为 7.7 分（IQR：10-6）。主要障碍是缺乏时间/工作量过大以及专业资源不足：西班牙介入放射医师清楚地认识到为患者提供纵向护理的重要性。结论：西班牙介入放射医师清楚地认识到为患者提供纵向护理的重要性，但他们表示仅承担了治疗患者的部分临床责任。

{"title":"Current Status of the clinical role in Spanish interventional radiology: An online survey among the Spanish Society of Vascular and Interventional Radiology (SERVEI) members","authors":"Pedro Blas García Jurado , Juan José Espejo Herrero , María Sagrario Lombardo Galera , María Eugenia Pérez Montilla , Sara Barranco Acosta , José García-Revillo , Pilar Font Ugalde , Marina Álvarez Benito","doi":"10.1016/j.ejrad.2024.111829","DOIUrl":"10.1016/j.ejrad.2024.111829","url":null,"abstract":"<div><h3>Purpose</h3><div>This work aims to provide an overview of the current reality of clinical practice in interventional radiology in Spain, evaluating clinical activity, interventional radiologists’ opinion on the importance of playing a proactive clinical role, and the barriers they encounter in doing so.</div></div><div><h3>Materials and Methods</h3><div>The study was based on an 18-question survey divided into four categories: general aspects, clinical activity, opinion on a proactive clinical role, and barriers. The questionnaire, validated by the Spanish Society of Vascular and Interventional Radiology (SERVEI), was distributed to all members (n = 483) via email. A descriptive statistical analysis was performed.</div></div><div><h3>Results</h3><div>The response rate was 26.5% (128/483). A total of 44.5% (57/128) had admitting privileges, 70.3% (90/128) had consultations, 32.8% (42/128) did ward rounds, and 94.5% (121/128) participated in multidisciplinary committees. Most spent just 0%–10% of their workday on clinical activity. A total of 43.7% (56/128) reported providing longitudinal care for their patients. On a Likert scale from 1 to 10, the importance of performing pre-procedural consultations was rated a mean of 8.3 (IQR: 10–8), post-procedural consultations 8.1 (IQR: 10–7), and care during hospitalization 7.7 (IQR: 10–6). The main obstacles were a lack of time/excessive workload and inadequate professional resources.</div></div><div><h3>Conclusions</h3><div>Spanish interventional radiologists demonstrated a clear awareness of the importance of providing longitudinal patient care. However, they reported only partially taking on the clinical responsibilities for the patients they treated.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"181 ","pages":"Article 111829"},"PeriodicalIF":3.2,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142617565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of coating damage and shape retention quantity of microcatheter by different shaping methods 不同整形方法下微导管涂层损伤和形状保持量的比较

IF 3.2 3区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

European Journal of Radiology

Pub Date : 2024-11-06 DOI: 10.1016/j.ejrad.2024.111815

Qiuyu Lu, Rui Zhao, Qiang Li, Qinghai Huang, Yi Xu, Pengfei Yang, Qiao Zuo, Jianmin Liu

Objective

To compare the coating damage and shape retention quality of microcatheter by steam (ST), hot air gun (HA), and HA + ST shaping.

Method

SL-10, XT-17, and Q-track microcatheters were included in the study. MarSurf CM explorer (a non-contact 3D confocal microscopy system) and MATLAB software were used to detect the surface coating damage. To detect the shape retention quantity, ImageJ software was used to analyze the images of the shaped microcatheters. Temperature of the outlet of the ST and HA was measured using a high precision contact digital thermometer.

Results

HA could reach the preset temperature (3 ∼ 4 s) 17 times faster than an ST (54 s). HA + ST produced relatively consistent heat flow output. HA had better shape retention quantity than ST, and HA + ST had a relatively better shape retention quantity compared with ST or HA alone. ST had a protective effect on the hydrophilic coating on the surface of microcatheter, and shaping by ST + HA could reduce the damage caused by HA to the surface coating.

Conclusions

HA and ST had their own advantages in microcatheter shaping. HA had a better shape retention quantity than ST, and reached the setting temperature faster than ST. ST had the ability to better protect the coating than HA. A device capable of simultaneously generating efficient and stable heat flow and eliminating heat flow damage to the surface coating can be designed for ideal microcatheter shaping.

摘要比较蒸汽（ST）、热风枪（HA）和 HA + ST 整形对微量导管涂层的损伤和形状保持质量：研究对象包括 SL-10、XT-17 和 Q 轨迹微导管。使用 MarSurf CM explorer（非接触式三维共聚焦显微镜系统）和 MATLAB 软件检测表面涂层损伤。为了检测形状保持量，使用了 ImageJ 软件来分析形状微导管的图像。使用高精度接触式数字温度计测量 ST 和 HA 出口的温度：HA 达到预设温度（3 ∼ 4 秒）的速度是 ST（54 秒）的 17 倍。HA + ST 能产生相对稳定的热流输出。HA 的形状保持量优于 ST，HA + ST 的形状保持量相对优于 ST 或 HA。ST 对微导管表面的亲水涂层有保护作用，用 ST + HA 塑形可减少 HA 对表面涂层的破坏：结论：HA 和 ST 在微导管塑形中各有优势。结论：HA 和 ST 在微导管成型中各有优势，HA 的形状保持量优于 ST，达到成型温度的速度也快于 ST。与 HA 相比，ST 能够更好地保护涂层。设计一种能同时产生高效稳定热流和消除热流对表面涂层损伤的装置，可实现理想的微导管成型。

{"title":"Comparison of coating damage and shape retention quantity of microcatheter by different shaping methods","authors":"Qiuyu Lu, Rui Zhao, Qiang Li, Qinghai Huang, Yi Xu, Pengfei Yang, Qiao Zuo, Jianmin Liu","doi":"10.1016/j.ejrad.2024.111815","DOIUrl":"10.1016/j.ejrad.2024.111815","url":null,"abstract":"<div><h3>Objective</h3><div>To compare the coating damage and shape retention quality of microcatheter by steam (ST), hot air gun (HA), and HA + ST shaping.</div></div><div><h3>Method</h3><div>SL-10, XT-17, and Q-track microcatheters were included in the study. MarSurf CM explorer (a non-contact 3D confocal microscopy system) and MATLAB software were used to detect the surface coating damage. To detect the shape retention quantity, ImageJ software was used to analyze the images of the shaped microcatheters. Temperature of the outlet of the ST and HA was measured using a high precision contact digital thermometer.</div></div><div><h3>Results</h3><div>HA could reach the preset temperature (3 ∼ 4 s) 17 times faster than an ST (54 s). HA + ST produced relatively consistent heat flow output. HA had better shape retention quantity than ST, and HA + ST had a relatively better shape retention quantity compared with ST or HA alone. ST had a protective effect on the hydrophilic coating on the surface of microcatheter, and shaping by ST + HA could reduce the damage caused by HA to the surface coating.</div></div><div><h3>Conclusions</h3><div>HA and ST had their own advantages in microcatheter shaping. HA had a better shape retention quantity than ST, and reached the setting temperature faster than ST. ST had the ability to better protect the coating than HA. A device capable of simultaneously generating efficient and stable heat flow and eliminating heat flow damage to the surface coating can be designed for ideal microcatheter shaping.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"181 ","pages":"Article 111815"},"PeriodicalIF":3.2,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142617560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Myocardial fibrosis is associated with brain microstructural alterations in patients with heart failure: A diffusion MRI study 心肌纤维化与心力衰竭患者大脑微结构改变有关：弥散核磁共振成像研究

IF 3.2 3区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

European Journal of Radiology

Pub Date : 2024-11-06 DOI: 10.1016/j.ejrad.2024.111813

Chong Zheng , Yadong Cui , Shanshan Gu , Jin Si , Keling Xiao , Zengpin Lin , Yang Yang , Jing Li , Jie Lu

Purpose

This study aimed to examine the changes in brain diffusion in patients with heart failure (HF) by measuring the apparent diffusion coefficient (ADC) and to investigate the relationship between these changes and cardiac injury features.

Methods

The study included 49 patients with HF and 39 healthy controls. Cognitive performance was assessed using the Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA). All participants underwent a brain DWI scan, followed by cardiac MR in patients with HF. The ADC values in different regions of the brain were estimated using region-of-interest analysis. Cardiac MR was used to evaluate left ventricular function and the volume of late gadolinium enhancement (LGE). Group differences in ADC values were analysed using generalised linear mixed modelling. Correlation analysis was used to explore the associations between brain diffusion alterations, cognitive performance, and cardiac injury features.

Results

Patients with HF showed significantly increased ADC values in several brain regions, including the frontal, parietal, temporal, occipital lobes, cingulate cortex, hippocampus, cerebellum, and deep nuclei. ADC values in the right hippocampus, right amygdala, and bilateral insula were negatively correlated with MoCA scores. ADC values in the left inferior occipital gyrus (r = 0.570, P<0.001) and lobule VI of the cerebellar hemisphere (r = 0.560, P = 0.001) were correlated with LGE volume.

Conclusion

These findings suggest that specific brain regions in patients with HF experience microstructural changes associated with cognitive impairment. Moreover, chronic brain microstructural alterations may be related to myocardial fibrosis in patients with HF.

目的：本研究旨在通过测量表观弥散系数（ADC），研究心力衰竭（HF）患者脑弥散的变化，并探讨这些变化与心脏损伤特征之间的关系：研究对象包括49名心力衰竭患者和39名健康对照者。认知能力采用迷你精神状态检查（MMSE）和蒙特利尔认知评估（MoCA）进行评估。所有参试者均接受了脑部 DWI 扫描，HF 患者随后接受了心脏 MR 扫描。大脑不同区域的 ADC 值通过感兴趣区分析进行估算。心脏磁共振用于评估左心室功能和晚期钆增强（LGE）的体积。使用广义线性混合模型分析了 ADC 值的组间差异。相关分析用于探讨大脑弥散改变、认知能力和心脏损伤特征之间的关联：结果：高频患者多个脑区的 ADC 值明显增加，包括额叶、顶叶、颞叶、枕叶、扣带回皮层、海马、小脑和深核。右侧海马、右侧杏仁核和双侧岛叶的 ADC 值与 MoCA 评分呈负相关。左枕骨下回的 ADC 值（r = 0.570，PC 结论：这些研究结果表明，MoCA 患者的特定脑区与他们的得分呈负相关：这些研究结果表明，高频患者的特定脑区会出现与认知障碍相关的微结构变化。此外，慢性脑部微结构改变可能与心房颤动患者的心肌纤维化有关。

{"title":"Myocardial fibrosis is associated with brain microstructural alterations in patients with heart failure: A diffusion MRI study","authors":"Chong Zheng , Yadong Cui , Shanshan Gu , Jin Si , Keling Xiao , Zengpin Lin , Yang Yang , Jing Li , Jie Lu","doi":"10.1016/j.ejrad.2024.111813","DOIUrl":"10.1016/j.ejrad.2024.111813","url":null,"abstract":"<div><h3>Purpose</h3><div>This study aimed to examine the changes in brain diffusion in patients with heart failure (HF) by measuring the apparent diffusion coefficient (ADC) and to investigate the relationship between these changes and cardiac injury features.</div></div><div><h3>Methods</h3><div>The study included 49 patients with HF and 39 healthy controls. Cognitive performance was assessed using the Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA). All participants underwent a brain DWI scan, followed by cardiac MR in patients with HF. The ADC values in different regions of the brain were estimated using region-of-interest analysis. Cardiac MR was used to evaluate left ventricular function and the volume of late gadolinium enhancement (LGE). Group differences in ADC values were analysed using generalised linear mixed modelling. Correlation analysis was used to explore the associations between brain diffusion alterations, cognitive performance, and cardiac injury features.</div></div><div><h3>Results</h3><div>Patients with HF showed significantly increased ADC values in several brain regions, including the frontal, parietal, temporal, occipital lobes, cingulate cortex, hippocampus, cerebellum, and deep nuclei. ADC values in the right hippocampus, right amygdala, and bilateral insula were negatively correlated with MoCA scores. ADC values in the left inferior occipital gyrus (<em>r</em> = 0.570, <em>P</em><0.001) and lobule VI of the cerebellar hemisphere (<em>r</em> = 0.560, <em>P</em> = 0.001) were correlated with LGE volume.</div></div><div><h3>Conclusion</h3><div>These findings suggest that specific brain regions in patients with HF experience microstructural changes associated with cognitive impairment. Moreover, chronic brain microstructural alterations may be related to myocardial fibrosis in patients with HF.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"182 ","pages":"Article 111813"},"PeriodicalIF":3.2,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142644242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CT assessment of liver fat fraction and abdominal fat composition can predict postoperative liver metastasis of colorectal cancer CT 评估肝脏脂肪分数和腹部脂肪组成可预测结直肠癌术后肝转移。

IF 3.2 3区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

European Journal of Radiology

Pub Date : 2024-11-06 DOI: 10.1016/j.ejrad.2024.111814

Ke Yin , Guanyi Liao , Hong Peng , Suhe Lai , Jinjun Guo

Objective

The aim of this study is to investigate the clinical value of liver fat fraction assessed by CT(CT-LFF) and abdominal fat components. We focus on predicting liver metastasis (LM) after colorectal cancer (CRC) surgery.

Methods

Clinical and imaging data from 79 patients who underwent radical CRC surgery between January 2019 and December 2021 were retrospectively collected. Semi-automatic software was used to quantify the area of different body tissues at the level of the third lumbar vertebra, and liver fat fraction was calculated based on the CT values. Patients were grouped according to BMI, tumor grade, T stage, N stage, vascular invasion (VI), perineural invasion (PNI), and preoperative levels of CEA and CA199. A multivariate logistic regression model was used to identify independent risk factors for early LM after surgery. The diagnostic performance was assessed using the receiver operating characteristic analysis with 5-fold cross-validation. The Kaplan-Meier method was used to draw survival curves, and Log-Rank test was used for survival analysis.

Results

The study found that the occurrence of LM after CRC surgery was significantly associated with CA199 positivity, VI, PNI, N1-2 stage, CT-LFF, VAT index (VATI). Multivariate logistic regression analysis showed that CA199 positivity (OR = 7.659), N1-2 stage (OR = 6.394), CT-LFF (OR = 1.271), VATI (OR = 1.043) were independent risk factors for predicting LM after CRC surgery. The multivariate logistic regression model, constructed using these independent risk factors, demonstrated robust predictive performance across 5-fold cross-validations, with an average AUC of 0.898 (95 % CI: 0.828–0.969). Survival analysis showed a significant difference in liver metastasis-free survival rates between the high-risk and low-risk groups (P < 0.001).

Conclusion

CT-LFF and VATI assessed by CT are independent risk factors for predicting LM after CRC surgery. The multivariate prediction model combining CA199 and N stage shows high predictive performance.

研究目的本研究旨在探讨 CT（CT-LFF）评估的肝脏脂肪分数和腹部脂肪成分的临床价值。我们的研究重点是预测结直肠癌（CRC）手术后的肝转移（LM）：方法：回顾性收集了2019年1月至2021年12月期间接受CRC根治术的79例患者的临床和影像学数据。使用半自动软件量化第三腰椎水平不同身体组织的面积，并根据 CT 值计算肝脏脂肪分数。根据体重指数、肿瘤分级、T期、N期、血管侵犯（VI）、神经周围侵犯（PNI）以及术前CEA和CA199水平对患者进行分组。采用多变量逻辑回归模型确定术后早期LM的独立风险因素。采用接收者操作特征分析和 5 倍交叉验证评估了诊断效果。采用 Kaplan-Meier 法绘制生存曲线，并用 Log-Rank 检验进行生存分析：研究发现，CRC术后LM的发生与CA199阳性、VI、PNI、N1-2期、CT-LFF、VATI指数（VATI）显著相关。多变量逻辑回归分析显示，CA199 阳性（OR = 7.659）、N1-2 分期（OR = 6.394）、CT-LFF（OR = 1.271）、VATI（OR = 1.043）是预测 CRC 术后 LM 的独立危险因素。利用这些独立风险因素构建的多变量逻辑回归模型在5倍交叉验证中表现出了稳健的预测性能，平均AUC为0.898（95 % CI：0.828-0.969）。生存率分析表明，高风险组和低风险组的无肝转移生存率存在显著差异（P 结论：高风险组和低风险组的无肝转移生存率存在显著差异：CT-LFF 和 CT 评估的 VATI 是预测 CRC 术后 LM 的独立风险因素。结合 CA199 和 N 分期的多变量预测模型显示出较高的预测能力。

{"title":"CT assessment of liver fat fraction and abdominal fat composition can predict postoperative liver metastasis of colorectal cancer","authors":"Ke Yin , Guanyi Liao , Hong Peng , Suhe Lai , Jinjun Guo","doi":"10.1016/j.ejrad.2024.111814","DOIUrl":"10.1016/j.ejrad.2024.111814","url":null,"abstract":"<div><h3>Objective</h3><div>The aim of this study is to investigate the clinical value of liver fat fraction assessed by CT(CT-LFF) and abdominal fat components. We focus on predicting liver metastasis (LM) after colorectal cancer (CRC) surgery.</div></div><div><h3>Methods</h3><div>Clinical and imaging data from 79 patients who underwent radical CRC surgery between January 2019 and December 2021 were retrospectively collected. Semi-automatic software was used to quantify the area of different body tissues at the level of the third lumbar vertebra, and liver fat fraction was calculated based on the CT values. Patients were grouped according to BMI, tumor grade, T stage, N stage, vascular invasion (VI), perineural invasion (PNI), and preoperative levels of CEA and CA199. A multivariate logistic regression model was used to identify independent risk factors for early LM after surgery. The diagnostic performance was assessed using the receiver operating characteristic analysis with 5-fold cross-validation. The Kaplan-Meier method was used to draw survival curves, and Log-Rank test was used for survival analysis.</div></div><div><h3>Results</h3><div>The study found that the occurrence of LM after CRC surgery was significantly associated with CA199 positivity, VI, PNI, N1-2 stage, CT-LFF, VAT index (VATI). Multivariate logistic regression analysis showed that CA199 positivity (OR = 7.659), N1-2 stage (OR = 6.394), CT-LFF (OR = 1.271), VATI (OR = 1.043) were independent risk factors for predicting LM after CRC surgery. The multivariate logistic regression model, constructed using these independent risk factors, demonstrated robust predictive performance across 5-fold cross-validations, with an average AUC of 0.898 (95 % CI: 0.828–0.969). Survival analysis showed a significant difference in liver metastasis-free survival rates between the high-risk and low-risk groups (P < 0.001).</div></div><div><h3>Conclusion</h3><div>CT-LFF and VATI assessed by CT are independent risk factors for predicting LM after CRC surgery. The multivariate prediction model combining CA199 and N stage shows high predictive performance.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"181 ","pages":"Article 111814"},"PeriodicalIF":3.2,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142638046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0