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Non-emergent hemoptysis in patients with primary or metastatic lung tumors: The role of transarterial embolization 原发性或转移性肺肿瘤患者的非突发咯血:经动脉栓塞术的作用。
IF 3.2 3区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-10-12 DOI: 10.1016/j.ejrad.2024.111786
Ruben Geevarghese , Elena Petre , Etay Ziv , Ernesto Santos , Lee Rodriguez , Ken Zhao , Vlasios S. Sotirchos , Stephen B. Solomon , Erica S. Alexander

Purpose

To evaluate the role of systemic arterial embolization for the management of non-emergent hemoptysis in patients with primary or metastatic lung tumors.

Materials and methods

This is a retrospective single center study of consecutive patients who underwent systemic arterial embolization for non-emergent hemoptysis between 2011 and 2023. Study endpoints included technical success, clinical success (partial or complete resolution of hemoptysis) and overall survival. Hemoptysis-free and overall survival were estimated using the Kaplan-Meier method. Predictive factors for hemoptysis-free survival and overall survival were evaluated using univariate analysis (Cox regression). Post-procedural 30-day adverse events were recorded in line with Common Terminology Criteria for Adverse Events (CTCAE) v5.0.

Results

A total of 30 patients were identified. Technical success was achieved in 24/30 (80 %) patients. Clinical success following embolization was achieved in 23/30 (76.7 %) patients. Median length of hospitalization was 5 days (Range: 1 to 16 days). Median overall survival was 194 days (95 % CI: 89 to 258). Median hemoptysis-free survival was 286 days (95 % CI: 42 to not reached). No significant clinical or procedural predictors of hemoptysis-free survival or overall survival were identified. Serious adverse events (CTCAE Grade > 3) occurred in 1 patient (3.4 % − fatal respiratory failure).

Conclusion

Embolization of non-emergent hemoptysis in patients with lung malignancies is safe and effective. Recurrence is however high in this patient population, likely due to the nature of the underlying disease.
目的:评估全身动脉栓塞治疗原发性或转移性肺肿瘤患者非突发咯血的作用:这是一项回顾性单中心研究,研究对象为2011年至2023年间因非急性咯血而接受全身动脉栓塞治疗的连续患者。研究终点包括技术成功率、临床成功率(咯血部分或完全止住)和总生存率。无咯血生存率和总生存率采用 Kaplan-Meier 法进行估算。采用单变量分析(Cox 回归)评估了无咯血生存率和总生存率的预测因素。根据《不良事件通用术语标准》(CTCAE)v5.0 版记录了手术后 30 天的不良事件:共确定了 30 名患者。24/30(80%)名患者取得了技术成功。23/30(76.7%)名患者在栓塞术后取得了临床成功。住院时间中位数为 5 天(范围:1 至 16 天)。总生存期中位数为 194 天(95 % CI:89 至 258 天)。无咯血生存期中位数为 286 天(95 % CI:42 天至未达到)。未发现无咯血生存期或总生存期的重要临床或程序预测因素。1名患者(3.4% - 致命性呼吸衰竭)发生了严重不良事件(CTCAE等级> 3):结论:对肺部恶性肿瘤患者的非急性咯血进行栓塞治疗是安全有效的。结论:对肺部恶性肿瘤患者进行非突发咯血栓塞治疗是安全有效的,但这类患者的复发率较高,这可能与潜在疾病的性质有关。
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引用次数: 0
Understanding the risk of ionizing radiation in breast imaging: Concepts and quantities, clinical importance, and future directions 了解乳腺成像中的电离辐射风险:概念和数量、临床重要性和未来方向。
IF 3.2 3区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-10-12 DOI: 10.1016/j.ejrad.2024.111784
S. Di Maria , T.J.A. van Nijnatten , C.R.L.P.N. Jeukens , S. Vedantham , M. Dietzel , P. Vaz

Background

Conventional mammography remains the primary imaging modality for state-of-the-art breast imaging practice and its benefit (both on diagnostic and screening) was largely reported. In mammography, the typical Mean Glandular Dose (MGD) from X-ray radiation to the breast spans, on average, from 1 to 10 mGy, depending on breast thicknesses, percentage of fibroglandular tissue, and on the examination purpose.

Methods

The aim of this narrative review is to describe the extent of radiation risk in X-ray breast imaging and discuss the main steps and parameters (e.g. MGD, screening frequency and number of examination views) that may have an influence on the radiation risk assessment.

Results

Even though the radiation doses used with these examinations are very low, as compared to other medical or natural radiation exposures, there is a non-negligible associated risk of radiation-induced cancer. Accurate radiation risk assessment permits to better balance the overall estimation of the benefit-to-risk ratio in X-ray breast imaging.

Conclusions

It is expected that a better knowledge about radiation-induced cancer risk among population could improve the communications skills between patients and clinicians and could help to increase the awareness in women about radiation risk perception for a transparent and proper informed choice of imaging exam.
背景:传统的乳腺 X 射线照相术仍然是最先进的乳腺成像实践中的主要成像方式,其优点(诊断和筛查)已被广泛报道。在乳腺 X 射线照相术中,X 射线辐射到乳房的典型平均腺体剂量(MGD)平均为 1 到 10 mGy,具体取决于乳房厚度、纤维腺体组织的百分比以及检查目的:本综述旨在描述 X 射线乳腺成像的辐射风险程度,并讨论可能对辐射风险评估产生影响的主要步骤和参数(如 MGD、筛查频率和检查次数):结果:尽管与其他医疗或自然辐射相比,这些检查使用的辐射剂量非常低,但辐射诱发癌症的相关风险不可忽视。准确的辐射风险评估可以更好地平衡 X 射线乳腺成像的总体效益风险比:预计提高人们对辐射诱发癌症风险的认识,可以改善患者与临床医生之间的沟通技巧,并有助于提高妇女对辐射风险的认识,从而在知情的情况下透明、正确地选择成像检查。
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引用次数: 0
“3 + X D” structured report in radiology standardized resident training: Can it meet high-level teaching objectives? 放射科住院医师规范化培训中的 "3 + X D "结构化报告:它能达到高层次的教学目标吗?
IF 3.2 3区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-10-11 DOI: 10.1016/j.ejrad.2024.111780
Qingling Yang , Rui Peng , Lina Ma , Ye Han , Lei Yuan , Danqing Yin , Aceng Li , Yang Wang , Minwen Zheng , Yayu Huang , Jing Ren

Purpose

To evaluate the impact of the innovative “3 + X D” structured report (SR) designed based on Bloom’s taxonomy on the learning outcomes of radiology residents during standardized training.

Methods

This is a prospective study that recruited 120 radiology residents from our hospital between 2020 and 2022. Randomly selected 60 residents from the 2020 grade to constituted the control group, and randomly selected 60 residents from the 2021 grade to formed the experimental group. The former group was trained utilizing the Free-text Reports (FTR) template, while the latter group received training with the “3 + X D” structured reports (SR) template. The learning outcomes of both groups was evaluated utilizing both objective and subjective measures. Objective assessments encompassed examinations of theoretical knowledge, diagnostic skills, and total scores, aligning with the cognitive domains of remembering, understanding, applying, and analyzing as outlined by Bloom’s Taxonomy. Subjective assessments, on the other hand, comprised survey questionnaires administered to residents and feedback from clinical instructors, which correlated with the higher-order cognitive level of analyzing, evaluating, and creating within Bloom’s Taxonomy.

Results

On 60 residents (mean age, 24.15 years ± 2.11[SD]; 25 male) from control group, and 60 residents (mean age, 24.58 years ± 1.88 [SD]; 27 male) from experimental group. Following the training, significant improvements were observed in the theoretical knowledge, diagnostic skills, and total scores for both groups (p < 0.001). Furthermore, the experimental group demonstrated significantly higher diagnostic skills and total scores compared to the control group (p < 0.001). However, no significant difference was observed in the theoretical knowledge exam between the two groups (p = 0.236). The questionnaire used for subjective assessments had good reliability (Cronbach α was 0.826) and acceptable validity (The KMO was 0.692). Additionally, the survey questionnaires indicated that the experimental group rated higher than the control group in terms of cultivating imaging thinking ability, diagnostic confidence, diagnostic speed, and the convenience of the templates (p < 0.001). Clinicians’ feedback scores for the experimental group markedly surpassed those for the control group (p < 0.05).

Conclusions

Utilizing the “3 + X D” SR template grounded in Bloom’s taxonomy for training, the professional competency of radiology residents, particularly their diagnostic skills, saw a marked enhancement, successfully meeting the higher-level educational objectives. Consequently, the “3 + X D” SR template is highly recommended for the standardized training of radiology residents.
目的:评估基于布卢姆分类法设计的创新型 "3 + X D "结构化报告(SR)对放射科住院医师规范化培训学习成果的影响:这是一项前瞻性研究,在 2020 年至 2022 年期间从我院招募了 120 名放射科住院医师。从 2020 级住院医师中随机抽取 60 人组成对照组,从 2021 级住院医师中随机抽取 60 人组成实验组。前者使用自由文本报告(FTR)模板进行培训,后者使用 "3 + X D "结构化报告(SR)模板进行培训。两组的学习成果均通过客观和主观两方面进行评估。客观评估包括对理论知识、诊断技能和总分的检查,与布卢姆分类学中的记忆、理解、应用和分析等认知领域相一致。另一方面,主观评估包括对住院医师进行的调查问卷和临床导师的反馈,这与布卢姆分类学中的分析、评估和创造等高阶认知水平相关:60 名住院医师(平均年龄为 24.15 岁 ± 2.11 [标码];25 名男性)来自对照组,60 名住院医师(平均年龄为 24.58 岁 ± 1.88 [标码];27 名男性)来自实验组。培训后,两组学员的理论知识、诊断技能和总分均有明显提高(P 结论:两组学员的理论知识、诊断技能和总分均有明显提高(P利用以布鲁姆分类学为基础的 "3 + X D "SR模板进行培训,放射科住院医师的专业能力,尤其是诊断技能有了明显提高,成功实现了更高层次的教育目标。因此,"3 + X D "SR模板被强烈推荐用于放射科住院医生的标准化培训。
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引用次数: 0
MRI-only breast cancers are less aggressive than cancers identifiable on conventional imaging 纯磁共振成像乳腺癌的侵袭性低于传统成像可识别的癌症。
IF 3.2 3区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-10-11 DOI: 10.1016/j.ejrad.2024.111781
Melis Baykara Ulusan , Francesca Ferrara , Emine Meltem , Paola Clauser , Thomas H. Helbich , Pascal A.T. Baltzer

Background

Magnetic resonance imaging (MRI) has a superior sensitivity for the diagnosis of breast cancer, leading to lesions primarily detected by MRI. Some of these lesions cannot be identified by targeted second-look ultrasound (SLUS) examinations and are thus referred to as MRI-only lesions. We hypothesize that biologically more aggressive cancers lead to more distinct tissue damage improving visibility on SLUS.

Objective

To investigate whether there are differences in cancer subtypes between MRI-only and SLUS-detected malignant lesions.

Methods

This retrospective single-center observational study evaluated 435 patients who received breast MRI examinations between January 2017 and December 2022, with at least one lesion primarily detected on MRI and histologically confirmed as malignant. Demographic characteristics, lesion type (mass or non-mass), MRI-assessed lesion size (mm), histological diagnosis, stage, immunohistochemical analysis (ER, PR, HER-2, Ki-67), and lymph node status were assessed and compared between MRI-only and SLUS-detected.

Results

Among 435 patients (mean age of 57.4 ± 13.3), 34.02 % (n = 148) were in the MRI-only group, while the remaining 65.98 % (n = 287) were identified by SLUS. MRI-only cases were significantly smaller in size (10 mm vs 20 mm), mostly staged as T1 (66.9 %) and showed features associated with less biological aggressiveness (higher pure ductal carcinoma in situ rates: 30.4 % vs 5.2 %; lower Ki-67, median values: 10 vs 20) compared to SLUS-detected cases (P < 0.001). SLUS-detected cancers had higher ratios of microscopic (4.9 % vs 3.4 %) and macroscopic axillary metastasis (26.8 % vs 7.4 %) compared to MRI-only lesions (P < 0.001).

Conclusion

MRI-only lesions presented histologically and immunohistochemically with less aggressive patterns compared to those detected via SLUS.
Clinic Impact: Our data provide evidence that MRI-only lesions are biologically less aggressive and of lower stage, offering the potential of earlier treatment chance since they are visible on MRI before becoming more aggressive and destructive.
背景:磁共振成像(MRI)在诊断乳腺癌方面具有更高的灵敏度,因此主要通过磁共振成像检测病灶。其中一些病灶无法通过有针对性的二维超声波(SLUS)检查确定,因此被称为仅磁共振成像病灶。我们假设,生物侵袭性更强的癌症会导致更明显的组织损伤,从而提高 SLUS 的可见度:研究仅 MRI 检测到的恶性病变与 SLUS 检测到的恶性病变在癌症亚型上是否存在差异:这项回顾性单中心观察研究评估了2017年1月至2022年12月期间接受乳腺MRI检查的435例患者,这些患者至少有一个病变主要是在MRI上检测到的,并经组织学证实为恶性病变。研究人员对患者的人口统计学特征、病灶类型(肿块或非肿块)、MRI评估的病灶大小(毫米)、组织学诊断、分期、免疫组化分析(ER、PR、HER-2、Ki-67)和淋巴结状态进行了评估,并对纯MRI检测和SLUS检测的病灶进行了比较:在435名患者(平均年龄为57.4 ± 13.3)中,仅磁共振成像组占34.02%(n = 148),其余65.98%(n = 287)通过SLUS检测。仅使用核磁共振成像的病例体积明显较小(10 毫米对 20 毫米),大部分分期为 T1(66.9%),并显示出与生物侵袭性较低相关的特征(纯导管原位癌率较高:30.4% 对 5.2%):30.4%对5.2%;Ki-67较低,中位值为10对20):与SLUS检测到的病例相比(P与 SLUS 检测到的病例相比,仅通过 MRI 检测到的病变在组织学和免疫组化方面的侵袭性较低。临床影响:我们的数据提供了证据,证明只在核磁共振成像上显示的病变在生物学上侵袭性较低且分期较低,这为早期治疗提供了机会,因为这些病变在变得更具侵袭性和破坏性之前就能在核磁共振成像上显示出来。
{"title":"MRI-only breast cancers are less aggressive than cancers identifiable on conventional imaging","authors":"Melis Baykara Ulusan ,&nbsp;Francesca Ferrara ,&nbsp;Emine Meltem ,&nbsp;Paola Clauser ,&nbsp;Thomas H. Helbich ,&nbsp;Pascal A.T. Baltzer","doi":"10.1016/j.ejrad.2024.111781","DOIUrl":"10.1016/j.ejrad.2024.111781","url":null,"abstract":"<div><h3>Background</h3><div>Magnetic resonance imaging (MRI) has a superior sensitivity for the diagnosis of breast cancer, leading to lesions primarily detected by MRI. Some of these lesions cannot be identified by targeted second-look ultrasound (SLUS) examinations and are thus referred to as MRI-only lesions. We hypothesize that biologically more aggressive cancers lead to more distinct tissue damage improving visibility on SLUS.</div></div><div><h3>Objective</h3><div>To investigate whether there are differences in cancer subtypes between MRI-only and SLUS-detected malignant lesions.</div></div><div><h3>Methods</h3><div>This retrospective single-center observational study evaluated 435 patients who received breast MRI examinations between January 2017 and December 2022, with at least one lesion primarily detected on MRI and histologically confirmed as malignant. Demographic characteristics, lesion type (mass or non-mass), MRI-assessed lesion size (mm), histological diagnosis, stage, immunohistochemical analysis (ER, PR, HER-2, Ki-67), and lymph node status were assessed and compared between MRI-only and SLUS-detected.</div></div><div><h3>Results</h3><div>Among 435 patients (mean age of 57.4 ± 13.3), 34.02 % (n = 148) were in the MRI-only group, while the remaining 65.98 % (n = 287) were identified by SLUS. MRI-only cases were significantly smaller in size (10 mm vs 20 mm), mostly staged as T1 (66.9 %) and showed features associated with less biological aggressiveness (higher pure ductal carcinoma in situ rates: 30.4 % vs 5.2 %; lower Ki-67, median values: 10 vs 20) compared to SLUS-detected cases (<em>P</em> &lt; 0.001). SLUS-detected cancers had higher ratios of microscopic (4.9 % vs 3.4 %) and macroscopic axillary metastasis (26.8 % vs 7.4 %) compared to MRI-only lesions (<em>P</em> &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>MRI-only lesions presented histologically and immunohistochemically with less aggressive patterns compared to those detected via SLUS.</div><div>Clinic Impact: Our data provide evidence that MRI-only lesions are biologically less aggressive and of lower stage, offering the potential of earlier treatment chance since they are visible on MRI before becoming more aggressive and destructive.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"181 ","pages":"Article 111781"},"PeriodicalIF":3.2,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142461237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Real-World evaluation of an AI triaging system for chest X-rays: A prospective clinical study 胸部 X 射线人工智能分诊系统的真实世界评估:前瞻性临床研究
IF 3.2 3区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-10-10 DOI: 10.1016/j.ejrad.2024.111783
Srinath Sridharan , Alicia Seah Xin Hui , Narayan Venkataraman , Prasanna Sivanath Tirukonda , Ram Pratab Jeyaratnam , Sindhu John , Saraswathy Suresh Babu , Perry Liew , Joe Francis , Tsai Koh Tzan , Wong Kang Min , Goh Min Liong , Charlene Liew Jin Yee
Chest X-rays (CXRs) are crucial for diagnosing and managing lung conditions. While CXR is a common and cost-effective diagnostic tool, interpreting the high volume of CXRs is challenging due to workforce limitations. Artificial intelligence (AI) offers promise in enhancing efficiency and accuracy. However, real-world applicability and generalizability across diverse patient cohorts remain areas of concerns. In our study, the LUNIT INSIGHT CXR Triage software was evaluated in a diverse patient cohort. Forty-three radiologists, blinded to AI results, assessed CXRs categorized into normal, non-urgent, and urgent using a 3-tier classification system. Performance metrics and turnaround times were analyzed.
The AI system demonstrated sensitivity of 89% for normal CXRs, specificity of 93%, PPV of 83%, and NPV of 95%, with an F1 score of 0.86 and an AUC of 0.91. For non-urgent CXRs, sensitivity and specificity were 93% and 91%, with PPV and NPV at 94% and 89%, respectively, and an F1 score of 0.94 and an AUC of 0.92. In the urgent category, sensitivity was 82%, specificity 99%, PPV 90%, and NPV 98%. Subgroup analysis revealed consistently high accuracy across various age groups (Young, Adult, Senior), genders, and ethnicities (Chinese, Malay, Indian, Others), with sensitivity, specificity, and AUC consistently above 84%. The AI system also significantly reduced turnaround times across all subgroups, indicating its robust performance and generalizability in diverse healthcare settings.
胸部 X 光检查 (CXR) 对于诊断和治疗肺部疾病至关重要。虽然 CXR 是一种常见且具有成本效益的诊断工具,但由于劳动力的限制,解释大量的 CXR 具有挑战性。人工智能(AI)有望提高效率和准确性。然而,现实世界的适用性和对不同患者群体的普适性仍然是令人担忧的问题。在我们的研究中,LUNIT INSIGHT CXR 分诊软件在不同的患者群体中进行了评估。43 名放射科医生在对人工智能结果保密的情况下,采用三级分类系统对分为正常、非紧急和紧急的 CXR 进行了评估。人工智能系统对正常 CXR 的灵敏度为 89%,特异性为 93%,PPV 为 83%,NPV 为 95%,F1 得分为 0.86,AUC 为 0.91。非急诊 CXR 的敏感性和特异性分别为 93% 和 91%,PPV 和 NPV 分别为 94% 和 89%,F1 得分为 0.94,AUC 为 0.92。在紧急类别中,灵敏度为 82%,特异性为 99%,PPV 为 90%,NPV 为 98%。分组分析表明,不同年龄组(青年、成年、老年)、性别和种族(华人、马来人、印度人、其他)的准确率都很高,灵敏度、特异性和 AUC 均高于 84%。该人工智能系统还大大缩短了所有亚组的周转时间,这表明它在不同医疗环境中具有强大的性能和通用性。
{"title":"Real-World evaluation of an AI triaging system for chest X-rays: A prospective clinical study","authors":"Srinath Sridharan ,&nbsp;Alicia Seah Xin Hui ,&nbsp;Narayan Venkataraman ,&nbsp;Prasanna Sivanath Tirukonda ,&nbsp;Ram Pratab Jeyaratnam ,&nbsp;Sindhu John ,&nbsp;Saraswathy Suresh Babu ,&nbsp;Perry Liew ,&nbsp;Joe Francis ,&nbsp;Tsai Koh Tzan ,&nbsp;Wong Kang Min ,&nbsp;Goh Min Liong ,&nbsp;Charlene Liew Jin Yee","doi":"10.1016/j.ejrad.2024.111783","DOIUrl":"10.1016/j.ejrad.2024.111783","url":null,"abstract":"<div><div>Chest X-rays (CXRs) are crucial for diagnosing and managing lung conditions. While CXR is a common and cost-effective diagnostic tool, interpreting the high volume of CXRs is challenging due to workforce limitations. Artificial intelligence (AI) offers promise in enhancing efficiency and accuracy. However, real-world applicability and generalizability across diverse patient cohorts remain areas of concerns. In our study, the LUNIT INSIGHT CXR Triage software was evaluated in a diverse patient cohort. Forty-three radiologists, blinded to AI results, assessed CXRs categorized into normal, non-urgent, and urgent using a 3-tier classification system. Performance metrics and turnaround times were analyzed.</div><div>The AI system demonstrated sensitivity of 89% for normal CXRs, specificity of 93%, PPV of 83%, and NPV of 95%, with an F1 score of 0.86 and an AUC of 0.91. For non-urgent CXRs, sensitivity and specificity were 93% and 91%, with PPV and NPV at 94% and 89%, respectively, and an F1 score of 0.94 and an AUC of 0.92. In the urgent category, sensitivity was 82%, specificity 99%, PPV 90%, and NPV 98%. Subgroup analysis revealed consistently high accuracy across various age groups (Young, Adult, Senior), genders, and ethnicities (Chinese, Malay, Indian, Others), with sensitivity, specificity, and AUC consistently above 84%. The AI system also significantly reduced turnaround times across all subgroups, indicating its robust performance and generalizability in diverse healthcare settings.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"181 ","pages":"Article 111783"},"PeriodicalIF":3.2,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142432468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Organ-Specific Iron Overload in Non-Transfusion-Dependent Thalassemia Patients: Insights from Quantitative MRI Evaluation 非输血依赖型地中海贫血患者器官特异性铁超载:核磁共振成像定量评估的启示。
IF 3.2 3区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-10-10 DOI: 10.1016/j.ejrad.2024.111750
Xiaojing Ning , Siyu Tan , Fei Peng , Chaotian Luo , Cheng Tang , Fangyan Xiao , Peng Peng

Objective

To elucidate the iron load in different organs of non-transfusion-dependent thalassemia (NTDT) patients using magnetic resonance imaging (MRI) T2* scan.

Methods

Thirty-four NTDT patients, including 28 NTDT iron chelation without and 6 NTDT with iron chelation, together with 15 normal controls, underwent MRI examination between December 2022 and July 2024 were enrolled in the study. Measured T2* of the pituitary gland, kidney cortex, heart, liver, pancreas, spleen. Liver and spleen volumes were evaluated.

Results

Of the 28 patients in NTDT without iron chelation group, 19 patients with iron overload in the liver, 9 patients with iron overload in the kidneys, and 4 patients with iron overload in the spleen. Most patients with abnormal kidney and spleen iron (76.9 %) had liver iron overload. Compared with the control group, NTDT without iron chelation patients had lower T2* in the liver, kidney, and spleen (p < 0.05). And heart T2* was correlated with kidney T2* (r = 0.480, p = 0.010) and pancreas (r = 0.411, p = 0.037). Liver T2* was correlated with spleen T2* (r = 0.479, p = 0.011). Pancreas T2* was correlated with pituitary T2* (r = -0.433, p = 0.031).

Conclusions

NTDT patients exhibit significant organ-specific iron overload, particularly in the liver, kidneys, and spleen. The correlations between iron levels in different organs suggest interconnected mechanisms of iron accumulation. These findings highlight the importance of regular MRI screening to monitor and manage iron overload in NTDT patients.
目的利用磁共振成像(MRI)T2*扫描,阐明非输血依赖型地中海贫血(NTDT)患者不同器官的铁负荷:34名非输血依赖型地中海贫血(NTDT)患者(包括28名未接受铁螯合剂治疗的非输血依赖型地中海贫血患者和6名接受铁螯合剂治疗的非输血依赖型地中海贫血患者)以及15名正常对照组患者在2022年12月至2024年7月期间接受了磁共振成像检查。测量了垂体、肾皮质、心脏、肝脏、胰腺和脾脏的 T2*。对肝脏和脾脏的体积进行了评估:在未进行铁螯合治疗的 28 名 NTDT 组患者中,19 名患者肝脏铁负荷过重,9 名患者肾脏铁负荷过重,4 名患者脾脏铁负荷过重。大多数肾脏和脾脏铁异常的患者(76.9%)都有肝脏铁超载。与对照组相比,未经铁螯合的 NTDT 患者肝脏、肾脏和脾脏的 T2* 均较低(P 结论:T2* 是指肝脏、肾脏和脾脏的铁含量:NTDT 患者表现出明显的器官特异性铁超载,尤其是肝脏、肾脏和脾脏。不同器官中铁含量之间的相关性表明铁积累的机制是相互关联的。这些发现强调了定期进行磁共振成像筛查以监测和管理 NTDT 患者铁超载的重要性。
{"title":"Organ-Specific Iron Overload in Non-Transfusion-Dependent Thalassemia Patients: Insights from Quantitative MRI Evaluation","authors":"Xiaojing Ning ,&nbsp;Siyu Tan ,&nbsp;Fei Peng ,&nbsp;Chaotian Luo ,&nbsp;Cheng Tang ,&nbsp;Fangyan Xiao ,&nbsp;Peng Peng","doi":"10.1016/j.ejrad.2024.111750","DOIUrl":"10.1016/j.ejrad.2024.111750","url":null,"abstract":"<div><h3>Objective</h3><div>To elucidate the iron load in different organs of non-transfusion-dependent thalassemia (NTDT) patients using magnetic resonance imaging (MRI) T2* scan.</div></div><div><h3>Methods</h3><div>Thirty-four NTDT patients, including 28 NTDT iron chelation without and 6 NTDT with iron chelation, together with 15 normal controls, underwent MRI examination between December 2022 and July 2024 were enrolled in the study. Measured T2* of the pituitary gland, kidney cortex, heart, liver, pancreas, spleen. Liver and spleen volumes were evaluated.</div></div><div><h3>Results</h3><div>Of the 28 patients in NTDT without iron chelation group, 19 patients with iron overload in the liver, 9 patients with iron overload in the kidneys, and 4 patients with iron overload in the spleen. Most patients with abnormal kidney and spleen iron (76.9 %) had liver iron overload. Compared with the control group, NTDT without iron chelation patients had lower T2* in the liver, kidney, and spleen (p &lt; 0.05). And heart T2* was correlated with kidney T2* (r = 0.480, p = 0.010) and pancreas (r = 0.411, p = 0.037). Liver T2* was correlated with spleen T2* (r = 0.479, p = 0.011). Pancreas T2* was correlated with pituitary T2* (r = -0.433, p = 0.031).</div></div><div><h3>Conclusions</h3><div>NTDT patients exhibit significant organ-specific iron overload, particularly in the liver, kidneys, and spleen. The correlations between iron levels in different organs suggest interconnected mechanisms of iron accumulation. These findings highlight the importance of regular MRI screening to monitor and manage iron overload in NTDT patients.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"181 ","pages":"Article 111750"},"PeriodicalIF":3.2,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142497616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A systematic scoping review exploring variation in practice in specimen mammography for Intraoperative Margin Analysis in Breast Conserving Surgery and the role of artificial intelligence in optimising diagnostic accuracy 探索保乳手术术中边缘分析标本乳腺摄影实践中的差异以及人工智能在优化诊断准确性中的作用的系统性范围界定综述。
IF 3.2 3区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-10-09 DOI: 10.1016/j.ejrad.2024.111777
Thomas J.E. Hubbard , Ola Shams , Benjamin Gardner , Finley Gibson , Sareh Rowlands , Tim Harries , Nick Stone

Purpose

Specimen Mammography (SM) is commonly used in Breast Conserving Surgery (BCS) for intraoperative margin analysis. A systematic scoping review was conducted to identify sources of methodological variation in Specimen Mammography Interpretation (SMI) and assess the role of Artificial Intelligence (AI) techniques to optimise Diagnostic Accuracy (DA).

Methods

Embase, Pubmed, Cochrane and web of science databases were searched. Studies were included if SM was used for margin analysis for BCS with reported DA compared with pathological margin status and data extracted.

Results

1242 unique studies were identified, of which 40 were included. 39/40 studies did not utilise AI for SMI, with 4 studies comparing 2 relevant techniques, giving 43 non-AI study arms for analysis. There was wide variation in SM techniques, including number of views and location of SM. Specialist performing SMI in usual clinical practice was surgeon (13/39 studies;33 %), radiologist(s) (16/39;41 %), surgeon and radiologist (3/39;8 %) or not stated (7/39;18 %) which differed from the study specialist in 15/39 (38 %) of studies. Diagnostic accuracy in studies ranged from sensitivity 19–91.7 % and specificity 25–100 %.

Conclusions

There is marked variation in current techniques used for SM for intraoperative margin analysis with correspondingly disparate DA. Only 1 study applied AI to SMI, and we identify how AI could optimise SMI and a template for future work to apply AI techniques to SMI, reduce unwarranted variation and optimise DA.
目的:保乳手术(BCS)中通常使用乳腺标本成像(SM)进行术中边缘分析。我们进行了一项系统性的范围界定综述,以确定标本乳腺 X 线造影术(SMI)方法差异的来源,并评估人工智能(AI)技术在优化诊断准确性(DA)方面的作用:方法:检索了 Embase、Pubmed、Cochrane 和 web of science 数据库。如果BCS的边缘分析使用了SM,且报告的DA与病理边缘状态进行了比较并提取了数据,则纳入研究:结果:共发现 1242 项独特的研究,其中 40 项被纳入。39/40项研究未使用AI进行SMI,其中4项研究比较了两种相关技术,因此有43项非AI研究臂可供分析。SM技术差异很大,包括视图的数量和SM的位置。在通常临床实践中执行 SMI 的专家是外科医生(13/39 项研究;33%)、放射科医生(16/39;41%)、外科医生和放射科医生(3/39;8%)或未说明(7/39;18%),其中 15/39 项研究(38%)的专家与研究专家不同。各项研究的诊断准确性介于敏感性19%-91.7%和特异性25%-100%之间:结论:目前用于术中边缘分析的 SM 技术存在明显差异,相应的诊断结果也不尽相同。只有 1 项研究将人工智能应用于 SMI,我们确定了人工智能如何优化 SMI,以及未来工作的模板,以便将人工智能技术应用于 SMI,减少不必要的差异并优化 DA。
{"title":"A systematic scoping review exploring variation in practice in specimen mammography for Intraoperative Margin Analysis in Breast Conserving Surgery and the role of artificial intelligence in optimising diagnostic accuracy","authors":"Thomas J.E. Hubbard ,&nbsp;Ola Shams ,&nbsp;Benjamin Gardner ,&nbsp;Finley Gibson ,&nbsp;Sareh Rowlands ,&nbsp;Tim Harries ,&nbsp;Nick Stone","doi":"10.1016/j.ejrad.2024.111777","DOIUrl":"10.1016/j.ejrad.2024.111777","url":null,"abstract":"<div><h3>Purpose</h3><div>Specimen Mammography (SM) is commonly used in Breast Conserving Surgery (BCS) for intraoperative margin analysis. A systematic scoping review was conducted to identify sources of methodological variation in Specimen Mammography Interpretation (SMI) and assess the role of Artificial Intelligence (AI) techniques to optimise Diagnostic Accuracy (DA).</div></div><div><h3>Methods</h3><div>Embase, Pubmed, Cochrane and web of science databases were searched. Studies were included if SM was used for margin analysis for BCS with reported DA compared with pathological margin status and data extracted.</div></div><div><h3>Results</h3><div>1242 unique studies were identified, of which 40 were included. 39/40 studies did not utilise AI for SMI, with 4 studies comparing 2 relevant techniques, giving 43 non-AI study arms for analysis. There was wide variation in SM techniques, including number of views and location of SM. Specialist performing SMI in usual clinical practice was surgeon (13/39 studies;33 %), radiologist(s) (16/39;41 %), surgeon and radiologist (3/39;8 %) or not stated (7/39;18 %) which differed from the study specialist in 15/39 (38 %) of studies. Diagnostic accuracy in studies ranged from sensitivity 19–91.7 % and specificity 25–100 %.</div></div><div><h3>Conclusions</h3><div>There is marked variation in current techniques used for SM for intraoperative margin analysis with correspondingly disparate DA. Only 1 study applied AI to SMI, and we identify how AI could optimise SMI and a template for future work to apply AI techniques to SMI, reduce unwarranted variation and optimise DA.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"181 ","pages":"Article 111777"},"PeriodicalIF":3.2,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142406273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Contrast enhanced mammography (CEM) guided biopsy using a prone table: A retrospective analysis of the preliminary experience in a single CEM referral center 使用俯卧台进行对比增强乳腺 X 线造影(CEM)引导活检:对一家 CEM 转诊中心初步经验的回顾性分析。
IF 3.2 3区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-10-09 DOI: 10.1016/j.ejrad.2024.111779
Jacopo Nori Cucchiari , Lucia Giudice , Ludovica Anna Incardona , Giacomo Di Filippo , Giulia Bicchierai , Elsa Cossu , Chiara Bellini , Ermanno Vanzi , Diego De Benedetto , Federica Di Naro , Cecilia Boeri , Sofia Vidali , Vittorio Miele

Background

This study evaluates the procedural efficacy and patient experience of Contrast Enhanced Mammography (CEM)-guided biopsies performed in a prone position using the Giotto Class 30,000 system. The emphasis is on the procedural advantages and clinical outcomes for “enhancing-only lesions” (EOLs).

Methods

A retrospective analysis of 524 CEM examinations conducted from December 2023 to June 2024 at a tertiary referral center was performed. Patients referred for pre-surgical staging or evaluation of inconclusive findings from conventional imaging were included. The study utilized dual-energy imaging and vacuum-assisted biopsy techniques, focusing on patients with at least one EOL identified in their initial CEM. Exclusions were based on the absence of a primary or follow-up CEM conducted at our facility Endpoints of this work included procedure efficiency which was evaluated in terms of technical success (biopsy completion with adequate sampling), dose distribution and timing and detection of additional lesions and patients’ comfort evaluation, based on the rate of complications (hematomas) and procedure interruption due to patients’ specific request or fainting events.

Results

Among the evaluated cases, 37 EOLs were biopsied. The average procedure time was 15.8 min. Biopsies were successfully completed in 100% of cases. However, complications occurred in 27% of cases, primarily as hematomas and a significant histological finding rate of 97.3% was recorded.

Conclusions

The use of the Giotto Class 30,000 system for CEM-guided biopsies in a prone position demonstrated high procedural success and was well-tolerated by patients, highlighting its potential to enhance procedural comfort and efficiency. These preliminary results validate the innovative approach, though further studies are required to solidify these findings and explore long-term outcomes.
背景:本研究评估了使用Giotto 30,000级系统在俯卧位进行造影剂增强乳腺X线摄影(CEM)引导下活检的疗效和患者体验。重点是 "仅增强病变"(EOL)的程序优势和临床结果:对一家三级转诊中心在 2023 年 12 月至 2024 年 6 月期间进行的 524 次 CEM 检查进行了回顾性分析。研究对象包括因手术前分期或常规成像检查结果不确定而转诊的患者。研究采用了双能量成像和真空辅助活检技术,重点关注在初次CEM中至少发现一个EOL的患者。这项工作的终点包括手术效率,评估指标包括技术成功率(活检完成并充分取样)、剂量分布和时间、额外病变的检测以及患者舒适度评估,评估指标包括并发症(血肿)发生率以及因患者特殊要求或晕厥事件而导致的手术中断:在接受评估的病例中,37 例 EOL 接受了活组织检查。平均手术时间为 15.8 分钟。100%的病例都成功完成了活检。然而,27%的病例出现了并发症,主要表现为血肿,组织学发现率高达97.3%:结论:使用Giotto Class 30,000系统在俯卧位进行CEM引导活检的手术成功率很高,患者的耐受性也很好,突显了该系统在提高手术舒适度和效率方面的潜力。这些初步结果验证了这一创新方法的有效性,但还需要进一步的研究来巩固这些结果并探讨长期效果。
{"title":"Contrast enhanced mammography (CEM) guided biopsy using a prone table: A retrospective analysis of the preliminary experience in a single CEM referral center","authors":"Jacopo Nori Cucchiari ,&nbsp;Lucia Giudice ,&nbsp;Ludovica Anna Incardona ,&nbsp;Giacomo Di Filippo ,&nbsp;Giulia Bicchierai ,&nbsp;Elsa Cossu ,&nbsp;Chiara Bellini ,&nbsp;Ermanno Vanzi ,&nbsp;Diego De Benedetto ,&nbsp;Federica Di Naro ,&nbsp;Cecilia Boeri ,&nbsp;Sofia Vidali ,&nbsp;Vittorio Miele","doi":"10.1016/j.ejrad.2024.111779","DOIUrl":"10.1016/j.ejrad.2024.111779","url":null,"abstract":"<div><h3>Background</h3><div>This study evaluates the procedural efficacy and patient experience of Contrast Enhanced Mammography (CEM)-guided biopsies performed in a prone position using the Giotto Class 30,000 system. The emphasis is on the procedural advantages and clinical outcomes for “enhancing-only lesions” (EOLs).</div></div><div><h3>Methods</h3><div>A retrospective analysis of 524 CEM examinations conducted from December 2023 to June 2024 at a tertiary referral center was performed. Patients referred for pre-surgical staging or evaluation of inconclusive findings from conventional imaging were included. The study utilized dual-energy imaging and vacuum-assisted biopsy techniques, focusing on patients with at least one EOL identified in their initial CEM. Exclusions were based on the absence of a primary or follow-up CEM conducted at our facility Endpoints of this work included procedure efficiency which was evaluated in terms of technical success (biopsy completion with adequate sampling), dose distribution and timing and detection of additional lesions and patients’ comfort evaluation, based on the rate of complications (hematomas) and procedure interruption due to patients’ specific request or fainting events.</div></div><div><h3>Results</h3><div>Among the evaluated cases, 37 EOLs were biopsied. The average procedure time was 15.8 min. Biopsies were successfully completed in 100% of cases. However, complications occurred in 27% of cases, primarily as hematomas and a significant histological finding rate of 97.3% was recorded.</div></div><div><h3>Conclusions</h3><div>The use of the Giotto Class 30,000 system for CEM-guided biopsies in a prone position demonstrated high procedural success and was well-tolerated by patients, highlighting its potential to enhance procedural comfort and efficiency. These preliminary results validate the innovative approach, though further studies are required to solidify these findings and explore long-term outcomes.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"181 ","pages":"Article 111779"},"PeriodicalIF":3.2,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142399828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Scandinavian Neurotrauma Guidelines: Frequency of intracranial hemorrhage in patients over 65 years old and on anti-platelet medication 斯堪的纳维亚神经创伤指南》:65 岁以上且服用抗血小板药物的患者颅内出血的频率。
IF 3.2 3区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-10-06 DOI: 10.1016/j.ejrad.2024.111778
Susanna Anetta Rathkjen , Flemming Skjøth , Maria Arvad Serifi , Andrew England , Helle Precht

Purpose

In 2013, the Scandinavian Neurotrauma Committee, produced an evidence-based guideline for the use of Computed Tomography (CT) in patients presenting following recent (<24 h) head injury (HI). A head CT scan is recommended for medium-risk patients with a Glasgow Coma Scale (GCS) score of 14–15, who are > 65 years old and on anti-platelet medication. The aim of this study was to determine the prevalence of intracranial hemorrhage (ICH) on head CT scans in this population, and to test for associations between ICH and baseline characteristics, symptoms and objective clinical findings.

Methods

This register-based retrospective study determined the prevalence of ICH on head CT scans performed over a 1-year period based on written CT-reports. Patient medical charts and imaging records were examined for data on symptomatology, objective findings and comorbidities.

Results

The study population included 325 unique head CT scans with a 5.2% prevalence of ICH. Risk ratios (RR’s) signified higher risk of ICH with a GCS score of 14 compared to a GCS score of 15 (RR 5.35, 95%CI 2.14–13.47). ICH risk was lower in patients on Clopidogrel medication compared to Acetylsalicylic Acid medication (RR 0.33, 95%CI 0.12–0.93).

Conclusions

The associations between ICH and the GCS score call attention to the importance of comprehensive clinical examination of HI patients to minimize CT overuse. The implications for patients and healthcare resources in scanning patients > 65 years on anti-platelet medication should be determined by future prospective studies.
目的:2013 年,斯堪的纳维亚神经创伤委员会制定了一项循证指南,规定对近期发病(65 岁以上且服用抗血小板药物)的患者使用计算机断层扫描(CT)。本研究旨在确定该人群头部 CT 扫描中颅内出血(ICH)的发生率,并检验 ICH 与基线特征、症状和客观临床发现之间的关联:这项以登记为基础的回顾性研究根据书面 CT 报告确定了一年内头部 CT 扫描中 ICH 的发生率。研究人员还检查了患者的病历和成像记录,以获取有关症状、客观检查结果和合并症的数据:研究对象包括 325 例头部 CT 扫描,ICH 发病率为 5.2%。风险比(RR)显示,与 GCS 评分 15 分相比,GCS 评分 14 分的患者发生 ICH 的风险更高(RR 5.35,95%CI 2.14-13.47)。与乙酰水杨酸药物相比,服用氯吡格雷药物的患者发生 ICH 的风险较低(RR 0.33,95%CI 0.12-0.93):ICH与GCS评分之间的关联提醒人们注意对HI患者进行全面临床检查的重要性,以尽量减少CT的过度使用。未来的前瞻性研究应确定对使用抗血小板药物的 65 岁以上患者进行扫描对患者和医疗资源的影响。
{"title":"Scandinavian Neurotrauma Guidelines: Frequency of intracranial hemorrhage in patients over 65 years old and on anti-platelet medication","authors":"Susanna Anetta Rathkjen ,&nbsp;Flemming Skjøth ,&nbsp;Maria Arvad Serifi ,&nbsp;Andrew England ,&nbsp;Helle Precht","doi":"10.1016/j.ejrad.2024.111778","DOIUrl":"10.1016/j.ejrad.2024.111778","url":null,"abstract":"<div><h3>Purpose</h3><div>In 2013, the Scandinavian Neurotrauma Committee, produced an evidence-based guideline for the use of Computed Tomography (CT) in patients presenting following recent (&lt;24 h) head injury (HI). A head CT scan is recommended for medium-risk patients with a Glasgow Coma Scale (GCS) score of 14–15, who are &gt; 65 years old and on anti-platelet medication. The aim of this study was to determine the prevalence of intracranial hemorrhage (ICH) on head CT scans in this population, and to test for associations between ICH and baseline characteristics, symptoms and objective clinical findings.</div></div><div><h3>Methods</h3><div>This register-based retrospective study determined the prevalence of ICH on head CT scans performed over a 1-year period based on written CT-reports. Patient medical charts and imaging records were examined for data on symptomatology, objective findings and comorbidities.</div></div><div><h3>Results</h3><div>The study population included 325 unique head CT scans with a 5.2% prevalence of ICH. Risk ratios (RR’s) signified higher risk of ICH with a GCS score of 14 compared to a GCS score of 15 (RR 5.35, 95%CI 2.14–13.47). ICH risk was lower in patients on Clopidogrel medication compared to Acetylsalicylic Acid medication (RR 0.33, 95%CI 0.12–0.93).</div></div><div><h3>Conclusions</h3><div>The associations between ICH and the GCS score call attention to the importance of comprehensive clinical examination of HI patients to minimize CT overuse. The implications for patients and healthcare resources in scanning patients &gt; 65 years on anti-platelet medication should be determined by future prospective studies.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"181 ","pages":"Article 111778"},"PeriodicalIF":3.2,"publicationDate":"2024-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142497621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Factors affecting the technical outcome of catheter-directed sclerotherapy for ovarian endometriomas 影响卵巢子宫内膜瘤导管导向硬化疗法技术成果的因素。
IF 3.2 3区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-10-04 DOI: 10.1016/j.ejrad.2024.111773
Dong Kyu Kim , Seok Kyo Seo , Kichang Han , Man-Deuk Kim , Joon Ho Kwon , Gyoung Min Kim , Hyung Cheol Kim , Jinyoung Choi , Juil Park , Sungmo Moon , Jong Yun Won

Purpose

To identify factors related to technical outcomes of catheter-directed sclerotherapy (CDS) and suggest selection criteria for CDS in patients with ovarian endometrioma.

Method

This retrospective study included patients with endometriomas treated with CDS between November 2015 and June 2023. The characteristics of the endometriomas, including diameter, morphology (unilocular or multilocular), and T2 signal intensity were evaluated using pre-procedure magnetic resonance imaging. Moreover, the size of the catheter (7- or 8.5-French) and route of access (transabdominal vs. transvaginal) was also analyzed. Multivariate logistic regression analyses were used to identify factors associated with the technical outcomes of CDS.

Results

Technical success was defined as successful completion of the following: 1) insertion of a 7- or 8.5-French catheter into the endometrioma, 2) full aspiration of the internal content, and 3) completion of sclerotherapy without ethanol leakage. Of the 323 women (mean age = 32.2 ± 6.0 years) with 401 endometriomas included in our study, technical success was achieved in 377 endometriomas (94.0 %). No major complications were observed. In the multivariate analysis, a diameter < 3 cm (odds ratio, 25.641; p < 0.001), T2 dark signal intensity (odds ratio, 7.462; p = 0.001), and transvaginal access (odds ratio, 4.016; p = 0.004) were associated with technical failure.

Conclusions

Small endometrioma size (<3cm), T2 dark signal intensity, and transvaginal access were identified as significant risk factors for technical failure during catheter-directed sclerotherapy.
目的:确定与导管导向硬化疗法(CDS)技术成果相关的因素,并提出卵巢子宫内膜异位症患者CDS的选择标准:这项回顾性研究纳入了2015年11月至2023年6月期间接受CDS治疗的子宫内膜异位症患者。通过术前磁共振成像评估了子宫内膜异位症的特征,包括直径、形态(单发或多发)和T2信号强度。此外,还分析了导管的尺寸(7 或 8.5 法分)和入路(经腹部或经阴道)。多变量逻辑回归分析用于确定与CDS技术结果相关的因素:技术成功的定义是成功完成以下工作:结果:技术成功的定义是成功完成以下工作:1)将 7 或 8.5 英尺长的导管插入子宫内膜异位瘤;2)完全抽吸内部内容物;3)完成硬化剂治疗且无乙醇渗漏。在 323 名患有 401 个子宫内膜异位症的妇女(平均年龄为 32.2 ± 6.0 岁)中,有 377 个子宫内膜异位症患者(94.0%)获得了技术成功。未发现重大并发症。在多变量分析中,直径小的子宫内膜瘤(0.5 厘米)和直径大的子宫内膜瘤(0.5 厘米)的结论一致:小的子宫内膜瘤 (
{"title":"Factors affecting the technical outcome of catheter-directed sclerotherapy for ovarian endometriomas","authors":"Dong Kyu Kim ,&nbsp;Seok Kyo Seo ,&nbsp;Kichang Han ,&nbsp;Man-Deuk Kim ,&nbsp;Joon Ho Kwon ,&nbsp;Gyoung Min Kim ,&nbsp;Hyung Cheol Kim ,&nbsp;Jinyoung Choi ,&nbsp;Juil Park ,&nbsp;Sungmo Moon ,&nbsp;Jong Yun Won","doi":"10.1016/j.ejrad.2024.111773","DOIUrl":"10.1016/j.ejrad.2024.111773","url":null,"abstract":"<div><h3>Purpose</h3><div>To identify factors related to technical outcomes of catheter-directed sclerotherapy (CDS) and suggest selection criteria for CDS in patients with ovarian endometrioma.</div></div><div><h3>Method</h3><div>This retrospective study included patients with endometriomas treated with CDS between November 2015 and June 2023. The characteristics of the endometriomas, including diameter, morphology (unilocular or multilocular), and T2 signal intensity were evaluated using pre-procedure magnetic resonance imaging. Moreover, the size of the catheter (7- or 8.5-French) and route of access (transabdominal vs. transvaginal) was also analyzed. Multivariate logistic regression analyses were used to identify factors associated with the technical outcomes of CDS.</div></div><div><h3>Results</h3><div>Technical success was defined as successful completion of the following: 1) insertion of a 7- or 8.5-French catheter into the endometrioma, 2) full aspiration of the internal content, and 3) completion of sclerotherapy without ethanol leakage. Of the 323 women (mean age = 32.2 ± 6.0 years) with 401 endometriomas included in our study, technical success was achieved in 377 endometriomas (94.0 %). No major complications were observed. In the multivariate analysis, a diameter &lt; 3 cm (odds ratio, 25.641; <em>p</em> &lt; 0.001), T2 dark signal intensity (odds ratio, 7.462; <em>p</em> = 0.001), and transvaginal access (odds ratio, 4.016; <em>p</em> = 0.004) were associated with technical failure.</div></div><div><h3>Conclusions</h3><div>Small endometrioma size (&lt;3cm), T2 dark signal intensity, and transvaginal access were identified as significant risk factors for technical failure during catheter-directed sclerotherapy.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"181 ","pages":"Article 111773"},"PeriodicalIF":3.2,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142406286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
European Journal of Radiology
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