Effective nitrogen (N) management is crucial for the sustainability of wheat production in China, yet achieving a balance between high yields, economic profitability, and environmental sustainability remains a major challenge. While optimal N application rates vary spatiotemporally, the interactions between N fertilization and environmental factors further complicate crop productivity predictions. To address this, a multilevel meta-regression framework was developed. Integrating 4961 observations from 571 publications, this framework enables a comprehensive assessment of optimal N rates for yield, economic, and environmental goals across China's seven major wheat-growing regions. These regions were delineated based on soil, climate, and varietal characteristics. The results revealed significant spatiotemporal variations in optimal N application rates, driven by regional differences in soil and climate conditions. Temporally, the yield-optimal N rate (YON) followed an inverted U-shaped trend, peaking in the 2000s (268 kg ha−1), whereas economic-optimal N rate (ECON) and environment-optimal N rate (ENON) showed a gradual increase. Region-specific N management thresholds optimize wheat production, boosting it by 15 % while simultaneously improving economic returns and reducing environmental pollution. Notably, yield responses to N optimization were influenced by soil-climate interactions, with harsher growing environments exhibiting greater marginal benefits from N fertilization compared to more favorable conditions. Crucially, N optimization effects varied even among similar production areas, underscoring the importance of localized agroecological adaptation. This study provides a data-driven framework for tailoring N management strategies to regional conditions, offering actionable insights for optimizing productivity, profitability, and sustainability in China's diverse wheat systems. The findings of this study not only refine N fertilizer recommendations but also equip policymakers and stakeholders with a holistic perspective on sustainable N management.
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